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Guy Salvesen

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0612
La Jolla CA 92093
Phone858-646-3114
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kasperkiewicz P, Kolt S, Janiszewski T, Groborz K, Poreba M, Snipas SJ, Salvesen GS, Drag M. Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes. Sci Rep. 2018 Oct 30; 8(1):15998. PMID: 30375474.
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    2. Vizovišek M, Vidmar R, Drag M, Fonovic M, Salvesen GS, Turk B. Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery. Trends Biochem Sci. 2018 Aug 07. PMID: 30097385.
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    3. Poreba M, Groborz K, Navarro M, Snipas SJ, Drag M, Salvesen GS. Caspase selective reagents for diagnosing apoptotic mechanisms. Cell Death Differ. 2018 May 10. PMID: 29748600.
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    4. Ramirez MLG, Poreba M, Snipas SJ, Groborz K, Drag M, Salvesen GS. Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1. J Biol Chem. 2018 May 04; 293(18):7058-7067. PMID: 29414788.
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    5. Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M. Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes. Chem Sci. 2018 Feb 28; 9(8):2113-2129. PMID: 29719685.
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    6. Ramirez MLG, Salvesen GS. A primer on caspase mechanisms. Semin Cell Dev Biol. 2018 Jan 12. PMID: 29329946.
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    7. Poreba M, Salvesen GS, Drag M. Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity. Nat Protoc. 2017 Oct; 12(10):2189-2214. PMID: 28933778.
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    8. Kasperkiewicz P, Altman Y, D'Angelo M, Salvesen GS, Drag M. Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils. J Am Chem Soc. 2017 Jul 26; 139(29):10115-10125. PMID: 28672107.
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    9. Poreba M, Salvesen G. Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death. Cell Chem Biol. 2017 May 18; 24(5):550-552. PMID: 28525771.
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    10. Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families. Sci Rep. 2017 Feb 23; 7:43135. PMID: 28230157.
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    11. Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, Rickert RC. Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation. J Immunol. 2017 02 01; 198(3):1066-1080. PMID: 28031341.
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    12. Fasci D, Anania V, Lill J, Salvesen G. Response to Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML". Sci Signal. 2016 Aug 09; 9(440):tc2. PMID: 27507652.
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    13. Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016 Aug 18; 23(8):1023-35. PMID: 27478158.
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    14. Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J. The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia. Sci Transl Med. 2016 05 18; 8(339):339ra69. PMID: 27194727.
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    15. Oroz-Parra I, Navarro M, Cervantes-Luevano KE, Álvarez-Delgado C, Salvesen G, Sanchez-Campos LN, Licea-Navarro AF. Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom. Toxins (Basel). 2016 Feb 05; 8(2):38. PMID: 26861394; PMCID: PMC4773791.
    16. Salvesen GS, Hempel A, Coll NS. Protease signaling in animal and plant-regulated cell death. FEBS J. 2016 07; 283(14):2577-98. PMID: 26648190.
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    17. Park G, Tan J, Garcia G, Kang Y, Salvesen G, Zhang Z. Regulation of Histone Acetylation by Autophagy in Parkinson Disease. J Biol Chem. 2016 Feb 12; 291(7):3531-40. PMID: 26699403; PMCID: PMC4751393 [Available on 02/12/17].
    18. Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M. Small Molecule Active Site Directed Tools for Studying Human Caspases. Chem Rev. 2015 Nov 25; 115(22):12546-629. PMID: 26551511.
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    19. Rajkovic J, Poreba M, Caglic D, Vidmar R, Wilk A, Borowik A, Salvesen G, Turk V, Drag M, Turk B. Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi. J Biol Chem. 2015 Nov 20; 290(47):28231-44. PMID: 26446788; PMCID: PMC4653680 [Available on 11/20/16].
    20. Hachmann J, Salvesen GS. The Paracaspase MALT1. Biochimie. 2016 Mar; 122:324-38. PMID: 26386283; PMCID: PMC4747852 [Available on 03/01/17].
    21. Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015 Oct 29; 526(7575):666-71. PMID: 26375259.
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    22. Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M. Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4. PLoS One. 2015; 10(7):e0132818. PMID: 26172376; PMCID: PMC4501687.
    23. Fasci D, Anania VG, Lill JR, Salvesen GS. SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML. Sci Signal. 2015 Jun 09; 8(380):ra56. PMID: 26060329; PMCID: PMC4603552.
    24. Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen GS. Probes to monitor activity of the paracaspase MALT1. Chem Biol. 2015 Jan 22; 22(1):139-47. PMID: 25556944; PMCID: PMC4304901.
    25. Kumar S, van Raam BJ, Salvesen GS, Cieplak P. Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates. PLoS One. 2014; 9(10):e110539. PMID: 25330111; PMCID: PMC4201543.
    26. Ashkenazi A, Salvesen G. Regulated cell death: signaling and mechanisms. Annu Rev Cell Dev Biol. 2014; 30:337-56. PMID: 25150011.
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    27. Salvesen GS, Walsh CM. Functions of caspase 8: the identified and the mysterious. Semin Immunol. 2014 Jun; 26(3):246-52. PMID: 24856110; PMCID: PMC4099255.
    28. Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G. Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation. J Biol Chem. 2014 May 30; 289(22):15544-53. PMID: 24713703; PMCID: PMC4140910.
    29. Byzia A, Haeggström JZ, Salvesen GS, Drag M. A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids. Amino Acids. 2014 May; 46(5):1313-20. PMID: 24573245; PMCID: PMC3984412.
    30. Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen GS, Drag M. Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2518-23. PMID: 24550277; PMCID: PMC3932852.
    31. Mace PD, Riedl SJ, Salvesen GS. Caspase enzymology and activation mechanisms. Methods Enzymol. 2014; 544:161-78. PMID: 24974290.
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    32. Poreba M, Strózyk A, Salvesen GS, Drag M. Caspase substrates and inhibitors. Cold Spring Harb Perspect Biol. 2013 Aug 01; 5(8):a008680. PMID: 23788633; PMCID: PMC3721276.
    33. Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND. Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. ACS Chem Biol. 2013 Apr 19; 8(4):725-32. PMID: 23323685; PMCID: PMC3953502.
    34. Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS. Activity, specificity, and probe design for the smallpox virus protease K7L. J Biol Chem. 2012 Nov 16; 287(47):39470-9. PMID: 23012361; PMCID: PMC3501048.
    35. Salvesen GS, Bogyo M. Highlight: the universe of proteolytic networks and mechanisms. Biol Chem. 2012 Sep; 393(9):841. PMID: 22944685.
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    36. Sivaraman KK, Oellig CA, Huynh K, Atkinson SC, Poreba M, Perugini MA, Trenholme KR, Gardiner DL, Salvesen G, Drag M, Dalton JP, Whisstock JC, McGowan S. X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP. J Mol Biol. 2012 Sep 28; 422(4):495-507. PMID: 22709581.
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    37. Conus S, Pop C, Snipas SJ, Salvesen GS, Simon HU. Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis. J Biol Chem. 2012 Jun 15; 287(25):21142-51. PMID: 22528489; PMCID: PMC3375537.
    38. Rickert RC, Salvesen GS, Ware CF. Mousing around with caspases and IAPs. Biochem J. 2012 Apr 15; 443(2):e1-2. PMID: 22452818.
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    39. Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS. Mechanism and specificity of the human paracaspase MALT1. Biochem J. 2012 Apr 01; 443(1):287-95. PMID: 22309193; PMCID: PMC3304489.
    40. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
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    41. Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M. An optimized activity-based probe for the study of caspase-6 activation. Chem Biol. 2012 Mar 23; 19(3):340-52. PMID: 22444589; PMCID: PMC3314226.
    42. Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR. Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4904-9. PMID: 22416118; PMCID: PMC3324028.
    43. Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M. Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. PLoS One. 2012; 7(2):e31938. PMID: 22359643; PMCID: PMC3281095.
    44. Dobrota C, Fasci D, Hadade ND, Roiban GD, Pop C, Meier VM, Dumitru I, Matache M, Salvesen GS, Funeriu DP. Glycine fluoromethylketones as SENP-specific activity based probes. Chembiochem. 2012 Jan 02; 13(1):80-4. PMID: 22134988.
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    45. Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen GS, Drag M. S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors. Biochimie. 2012 Mar; 94(3):704-10. PMID: 22085501.
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    46. Salvesen GS, Ashkenazi A. Snapshot: caspases. Cell. 2011 Oct 14; 147(2):476-476.e1. PMID: 22000022.
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    47. Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS. RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell. 2011 Oct 07; 44(1):9-16. PMID: 21981915; PMCID: PMC3192321.
    48. Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh CM. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15312-7. PMID: 21876153; PMCID: PMC3174674.
    49. Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonovic UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M. Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. Chem Biol. 2011 Jun 24; 18(6):711-21. PMID: 21700207; PMCID: PMC3131532.
    50. Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M. Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chem Biol. 2011 Jun 24; 18(6):722-32. PMID: 21700208; PMCID: PMC3131534.
    51. van Raam BJ, Salvesen GS. Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochim Biophys Acta. 2012 Jan; 1824(1):113-22. PMID: 21704196; PMCID: PMC3993904.
    52. Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH, Salvesen GS, Connolly ES, Troy CM. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. J Neurosci. 2011 Jun 15; 31(24):8894-904. PMID: 21677173; PMCID: PMC3143191.
    53. Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E. Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. Biochem J. 2011 Apr 15; 435(2):411-20. PMID: 21314638; PMCID: PMC4000605.
    54. Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature. 2011 Mar 17; 471(7338):363-7. PMID: 21368763; PMCID: PMC3077893.
    55. Pop C, Oberst A, Drag M, Van Raam BJ, Riedl SJ, Green DR, Salvesen GS. FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J. 2011 Feb 01; 433(3):447-457. PMID: 21235526; PMCID: PMC4024219.
    56. Békés M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen GS. The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. J Biol Chem. 2011 Mar 25; 286(12):10238-47. PMID: 21247896; PMCID: PMC3060478.
    57. Petroski MD, Salvesen GS, Wolf DA. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1749-50. PMID: 21245332; PMCID: PMC3033263.
    58. Timmer JC, Salvesen GS. N-terminomics: a high-content screen for protease substrates and their cleavage sites. Methods Mol Biol. 2011; 753:243-55. PMID: 21604127.
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    59. Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chem Biol. 2010 Nov 24; 17(11):1189-200. PMID: 21095569; PMCID: PMC3035168.
    60. Shu CW, Drag M, Bekes M, Zhai D, Salvesen GS, Reed JC. Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy. 2010 Oct; 6(7):936-47. PMID: 20818167; PMCID: PMC3039740.
    61. Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature. 2010 Oct 14; 467(7317):863-7. PMID: 20944749; PMCID: PMC3006164.
    62. Bratton SB, Salvesen GS. Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci. 2010 Oct 01; 123(Pt 19):3209-14. PMID: 20844150; PMCID: PMC2939798.
    63. Wachmann K, Pop C, van Raam BJ, Drag M, Mace PD, Snipas SJ, Zmasek C, Schwarzenbacher R, Salvesen GS, Riedl SJ. Activation and specificity of human caspase-10. Biochemistry. 2010 Sep 28; 49(38):8307-15. PMID: 20795673; PMCID: PMC2943529.
    64. Uhlmann F, Salvesen G. Divide and die another day. Curr Opin Cell Biol. 2010 Dec; 22(6):764-5. PMID: 20864325.
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    65. Kolli N, Mikolajczyk J, Drag M, Mukhopadhyay D, Moffatt N, Dasso M, Salvesen G, Wilkinson KD. Distribution and paralogue specificity of mammalian deSUMOylating enzymes. Biochem J. 2010 Sep 01; 430(2):335-44. PMID: 20590526; PMCID: PMC3749516.
    66. Drag M, Salvesen GS. Emerging principles in protease-based drug discovery. Nat Rev Drug Discov. 2010 Sep; 9(9):690-701. PMID: 20811381; PMCID: PMC2974563.
    67. Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR, Lipton SA. Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Mol Cell. 2010 Jul 30; 39(2):184-95. PMID: 20670888; PMCID: PMC2924818.
    68. Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR. Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem. 2010 May 28; 285(22):16632-42. PMID: 20308068; PMCID: PMC2878047.
    69. Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen GS, Janda KD, Felding-Habermann B. Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis. Clin Exp Metastasis. 2010 Apr; 27(4):217-31. PMID: 20225083; PMCID: PMC4830478.
    70. van Raam BJ, Salvesen GS. Transferring death: a role for tRNA in apoptosis regulation. Mol Cell. 2010 Mar 12; 37(5):591-2. PMID: 20227362.
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    71. Grzywa R, Oleksyszyn J, Salvesen GS, Drag M. Identification of very potent inhibitor of human aminopeptidase N (CD13). Bioorg Med Chem Lett. 2010 Apr 15; 20(8):2497-9. PMID: 20307982.
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    72. Zhai D, Yu E, Jin C, Welsh K, Shiau CW, Chen L, Salvesen GS, Liddington R, Reed JC. Vaccinia virus protein F1L is a caspase-9 inhibitor. J Biol Chem. 2010 Feb 19; 285(8):5569-80. PMID: 20022954; PMCID: PMC2820784.
    73. Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J. 2009 Dec 10; 424(3):335-45. PMID: 19788411; PMCID: PMC2805924.
    74. Drag M, Bogyo M, Ellman JA, Salvesen GS. Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. J Biol Chem. 2010 Jan 29; 285(5):3310-8. PMID: 19948737; PMCID: PMC2823418.
    75. Timmer JC, Zhu W, Pop C, Regan T, Snipas SJ, Eroshkin AM, Riedl SJ, Salvesen GS. Structural and kinetic determinants of protease substrates. Nat Struct Mol Biol. 2009 Oct; 16(10):1101-8. PMID: 19767749; PMCID: PMC4042863.
    76. Salvesen GS, Riedl SJ. Structure of the Fas/FADD complex: a conditional death domain complex mediating signaling by receptor clustering. Cell Cycle. 2009 Sep 01; 8(17):2723-7. PMID: 19652545; PMCID: PMC2788920.
    77. Cimadamore F, Curchoe CL, Alderson N, Scott F, Salvesen G, Terskikh AV. Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells. 2009 Aug; 27(8):1772-81. PMID: 19544437; PMCID: PMC4151857.
    78. Pop C, Salvesen GS. Human caspases: activation, specificity, and regulation. J Biol Chem. 2009 Aug 14; 284(33):21777-81. PMID: 19473994; PMCID: PMC2755903.
    79. Békés M, Salvesen GS. The CULt of caspase-8 ubiquitination. Cell. 2009 May 15; 137(4):604-6. PMID: 19450509.
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    80. Zhu S, Goeres J, Sixt KM, Békés M, Zhang XD, Salvesen GS, Matunis MJ. Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. Mol Cell. 2009 Mar 13; 33(5):570-80. PMID: 19285941; PMCID: PMC2668917.
    81. Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, Robinson H, Salvesen GS, Schwarzenbacher R, Riedl SJ. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature. 2009 Feb 19; 457(7232):1019-22. PMID: 19118384; PMCID: PMC2661029.
    82. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. PMID: 19001420; PMCID: PMC2613605.
    83. Drag M, Mikolajczyk J, Bekes M, Reyes-Turcu FE, Ellman JA, Wilkinson KD, Salvesen GS. Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes). Biochem J. 2008 Nov 01; 415(3):367-75. PMID: 18601651; PMCID: PMC2766241.
    84. Drag M, Salvesen GS. DeSUMOylating enzymes--SENPs. IUBMB Life. 2008 Nov; 60(11):734-42. PMID: 18666185.
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    85. Enoksson M, Salvesen GS. Proteolytic needles in the cellular haystack. Nat Chem Biol. 2008 Nov; 4(11):651-2. PMID: 18936746.
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    86. Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V, Turk B. Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem. 2008 Jul 04; 283(27):19140-50. PMID: 18469004.
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    87. Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, Salvesen GS. Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem. 2008 Jul 11; 283(28):19499-510. PMID: 18458084; PMCID: PMC2443678.
    88. Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS. Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. Biochem J. 2008 Jan 15; 409(2):461-9. PMID: 17916063.
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    89. Denault JB, Salvesen GS. Apoptotic caspase activation and activity. Methods Mol Biol. 2008; 414:191-220. PMID: 18175821.
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    90. Pop C, Salvesen GS, Scott FL. Caspase assays: identifying caspase activity and substrates in vitro and in vivo. Methods Enzymol. 2008; 446:351-67. PMID: 18603133.
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    91. Salvesen GS, Riedl SJ. Caspase mechanisms. Adv Exp Med Biol. 2008; 615:13-23. PMID: 18437889.
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    92. Wu YI, Munshi HG, Snipas SJ, Salvesen GS, Fridman R, Stack MS. Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking. Biochem J. 2007 Oct 15; 407(2):171-7. PMID: 17650075; PMCID: PMC2049019.
    93. Timmer JC, Enoksson M, Wildfang E, Zhu W, Igarashi Y, Denault JB, Ma Y, Dummitt B, Chang YH, Mast AE, Eroshkin A, Smith JW, Tao WA, Salvesen GS. Profiling constitutive proteolytic events in vivo. Biochem J. 2007 Oct 01; 407(1):41-8. PMID: 17650073; PMCID: PMC2267409.
    94. Denault JB, Drag M, Salvesen GS, Alves J, Heidt AB, Deveraux Q, Harris JL. Small molecules not direct activators of caspases. Nat Chem Biol. 2007 Sep; 3(9):519; author reply 520. PMID: 17710090.
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    95. Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A. Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells. J Biol Chem. 2007 Oct 12; 282(41):30216-26. PMID: 17681953.
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    96. Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS. Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J. 2007 Jul 01; 405(1):11-9. PMID: 17437405; PMCID: PMC1925235.
    97. Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS. Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. J Biol Chem. 2007 Sep 07; 282(36):26217-24. PMID: 17591783.
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    98. Enoksson M, Li J, Ivancic MM, Timmer JC, Wildfang E, Eroshkin A, Salvesen GS, Tao WA. Identification of proteolytic cleavage sites by quantitative proteomics. J Proteome Res. 2007 Jul; 6(7):2850-8. PMID: 17547438.
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    99. Salvesen GS, Riedl SJ. Caspase inhibition, specifically. Structure. 2007 May; 15(5):513-4. PMID: 17502096.
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    100. Riedl SJ, Salvesen GS. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol. 2007 May; 8(5):405-13. PMID: 17377525.
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    101. Pop C, Fitzgerald P, Green DR, Salvesen GS. Role of proteolysis in caspase-8 activation and stabilization. Biochemistry. 2007 Apr 10; 46(14):4398-407. PMID: 17371051.
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    102. Dobó J, Swanson R, Salvesen GS, Olson ST, Gettins PG. Cytokine response modifier a inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer. J Biol Chem. 2006 Dec 15; 281(50):38781-90. PMID: 17052983.
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    103. Eckelman BP, Salvesen GS, Scott FL. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep. 2006 Oct; 7(10):988-94. PMID: 17016456; PMCID: PMC1618369.
    104. Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen GS, Ganesan R, Jelakovic S, Grütter MG, Powers JC. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. J Med Chem. 2006 Sep 21; 49(19):5728-49. PMID: 16970398.
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    105. Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M. Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell. 2006 Aug; 23(4):509-21. PMID: 16916639.
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    106. Denault JB, Békés M, Scott FL, Sexton KM, Bogyo M, Salvesen GS. Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol Cell. 2006 Aug; 23(4):523-33. PMID: 16916640.
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    107. Pop C, Timmer J, Sperandio S, Salvesen GS. The apoptosome activates caspase-9 by dimerization. Mol Cell. 2006 Apr 21; 22(2):269-75. PMID: 16630894.
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    108. Stennicke HR, Salvesen GS. Chemical ligation--an unusual paradigm in protease inhibition. Mol Cell. 2006 Mar 17; 21(6):727-8. PMID: 16543139.
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    109. Eckelman BP, Salvesen GS. The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem. 2006 Feb 10; 281(6):3254-60. PMID: 16339151.
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    110. Pop C, Salvesen GS. The nematode death machine in 3D. Cell. 2005 Oct 21; 123(2):192-3. PMID: 16239138.
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    111. Simonovic M, Denault JB, Salvesen GS, Volz K, Gettins PG. Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions. Arch Biochem Biophys. 2005 Aug 01; 440(1):1-9. PMID: 15993378.
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    112. Kato D, Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, Chehade KA, Salvesen GS, Bogyo M. Activity-based probes that target diverse cysteine protease families. Nat Chem Biol. 2005 Jun; 1(1):33-8. PMID: 16407991.
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    113. Gregorc U, Dobersek A, Salvesen GS, Turk V, Turk B, Kopitar-Jerala N. A novel caspase-7 specific monoclonal antibody. Immunol Lett. 2005 Apr 15; 98(1):167-9. PMID: 15849872.
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    114. Scott FL, Denault JB, Riedl SJ, Shin H, Renatus M, Salvesen GS. XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J. 2005 Feb 09; 24(3):645-55. PMID: 15650747; PMCID: PMC548652.
    115. Bruckner S, Rhamouni S, Tautz L, Denault JB, Alonso A, Becattini B, Salvesen GS, Mustelin T. Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells. J Biol Chem. 2005 Mar 18; 280(11):10388-94. PMID: 15632192.
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    116. Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS. The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. Biochem J. 2005 Jan 01; 385(Pt 1):1-10. PMID: 15485395; PMCID: PMC1134667.
    117. Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 01; 385(Pt 1):11-20. PMID: 15485396; PMCID: PMC1134668.
    118. Fuentes-Prior P, Salvesen GS. The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J. 2004 Dec 01; 384(Pt 2):201-32. PMID: 15450003; PMCID: PMC1134104.
    119. Snipas SJ, Wildfang E, Nazif T, Christensen L, Boatright KM, Bogyo M, Stennicke HR, Salvesen GS. Characteristics of the caspase-like catalytic domain of human paracaspase. Biol Chem. 2004 Nov; 385(11):1093-8. PMID: 15576331.
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    120. Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S. Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Exp Neurol. 2004 Oct; 189(2):261-79. PMID: 15380478.
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    121. Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS, Duckett CS. Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J Biol Chem. 2004 Dec 03; 279(49):51082-90. PMID: 15371416.
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    122. Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS. Activation of caspases-8 and -10 by FLIP(L). Biochem J. 2004 Sep 01; 382(Pt 2):651-7. PMID: 15209560; PMCID: PMC1133822.
    123. Mikolajczyk J, Scott FL, Krajewski S, Sutherlin DP, Salvesen GS. Activation and substrate specificity of caspase-14. Biochemistry. 2004 Aug 17; 43(32):10560-9. PMID: 15301553.
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    124. Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC. An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13; 279(33):34087-90. PMID: 15218035.
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    125. Salvesen GS, Abrams JM. Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies. Oncogene. 2004 Apr 12; 23(16):2774-84. PMID: 15077141.
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    126. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 08; 47(8):1889-92. PMID: 15055989.
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    127. James KE, Asgian JL, Li ZZ, Ekici OD, Rubin JR, Mikolajczyk J, Salvesen GS, Powers JC. Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8. J Med Chem. 2004 Mar 11; 47(6):1553-74. PMID: 14998341.
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    128. Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC. Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. Blood. 2004 Aug 15; 104(4):932. PMID: 14739219.
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    129. Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell. 2004 Jan; 5(1):25-35. PMID: 14749124.
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    130. Wu YI, Munshi HG, Sen R, Snipas SJ, Salvesen GS, Fridman R, Stack MS. Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. J Biol Chem. 2004 Feb 27; 279(9):8278-89. PMID: 14670950.
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    131. Boatright KM, Salvesen GS. Mechanisms of caspase activation. Curr Opin Cell Biol. 2003 Dec; 15(6):725-31. PMID: 14644197.
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    132. Cirman T, Oresic K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem. 2004 Jan 30; 279(5):3578-87. PMID: 14581476.
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    133. Shin H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen GS. Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. Biochem J. 2003 Aug 01; 373(Pt 3):965-71. PMID: 12747801; PMCID: PMC1223557.
    134. Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier JM. XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells. J Exp Med. 2003 Jul 21; 198(2):341-7. PMID: 12874265; PMCID: PMC2194071.
    135. Denault JB, Salvesen GS. Human caspase-7 activity and regulation by its N-terminal peptide. J Biol Chem. 2003 Sep 05; 278(36):34042-50. PMID: 12824163.
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    136. Ryan CA, Salvesen GS. Caspases and neuronal development. Biol Chem. 2003 Jun; 384(6):855-61. PMID: 12887052.
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    137. Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun; 13(6B):1376-88. PMID: 12819136; PMCID: PMC403667.
    138. Salvesen GS, Scott FL. Serpins are getting hotter. Structure. 2003 Apr; 11(4):364-5. PMID: 12679013.
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    139. Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS. A unified model for apical caspase activation. Mol Cell. 2003 Feb; 11(2):529-41. PMID: 12620239.
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    140. Denault JB, Salvesen GS. Expression, purification, and characterization of caspases. Curr Protoc Protein Sci. 2003 Feb; Chapter 21:Unit 21.13. PMID: 18429241.
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    141. Mikolajczyk J, Boatright KM, Stennicke HR, Nazif T, Potempa J, Bogyo M, Salvesen GS. Sequential autolytic processing activates the zymogen of Arg-gingipain. J Biol Chem. 2003 Mar 21; 278(12):10458-64. PMID: 12533545.
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    142. Saklatvala J, Nagase H, Salvesen G. A tribute to Alan J. Barrett. Biochem Soc Symp. 2003; (70):ix-x. PMID: 14587277.
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    143. Boatright KM, Salvesen GS. Caspase activation. Biochem Soc Symp. 2003; (70):233-42. PMID: 14587296.
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    144. Denault JB, Salvesen GS. Caspases: keys in the ignition of cell death. Chem Rev. 2002 Dec; 102(12):4489-500. PMID: 12475198.
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    145. Asgian JL, James KE, Li ZZ, Carter W, Barrett AJ, Mikolajczyk J, Salvesen GS, Powers JC. Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases. J Med Chem. 2002 Nov 07; 45(23):4958-60. PMID: 12408706.
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    146. Ryan CA, Stennicke HR, Nava VE, Burch JB, Hardwick JM, Salvesen GS. Inhibitor specificity of recombinant and endogenous caspase-9. Biochem J. 2002 Sep 01; 366(Pt 2):595-601. PMID: 12067274; PMCID: PMC1222808.
    147. Troy CM, Salvesen GS. Caspases on the brain. J Neurosci Res. 2002 Jul 15; 69(2):145-50. PMID: 12111795.
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    148. Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 2002 Jun; 3(6):401-10. PMID: 12042762.
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    149. Gil-Parrado S, Fernández-Montalván A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26; 277(30):27217-26. PMID: 12000759.
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    150. Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3974-9. PMID: 11904443; PMCID: PMC122633.
    151. Salvesen GS, Renatus M. Apoptosome: the seven-spoked death machine. Dev Cell. 2002 Mar; 2(3):256-7. PMID: 11879630.
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    152. Stennicke HR, Ryan CA, Salvesen GS. Reprieval from execution: the molecular basis of caspase inhibition. Trends Biochem Sci. 2002 Feb; 27(2):94-101. PMID: 11852247.
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    153. Denault JB, Salvesen GS. Caspases. Curr Protoc Protein Sci. 2002 Feb; Chapter 21:Unit 21.8. PMID: 18429233.
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    154. Salvesen GS. Caspases: opening the boxes and interpreting the arrows. Cell Death Differ. 2002 Jan; 9(1):3-5. PMID: 11803369.
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    155. Lu C, Fu W, Salvesen GS, Mattson MP. Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death. Neuromolecular Med. 2002; 1(1):69-79. PMID: 12025817.
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    156. Turk B, Turk D, Salvesen GS. Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators. Curr Pharm Des. 2002; 8(18):1623-37. PMID: 12132995.
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    157. Salvesen GS. Caspases and apoptosis. Essays Biochem. 2002; 38:9-19. PMID: 12463158.
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