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Guy Salvesen

Title(s)Adjunct Professor, Pathology
SchoolHealth Sciences
Address9500 Gilman Drive #0612
La Jolla CA 92093
Phone858-646-3114
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Engineering Caspase 7 as an Affinity Reagent to Capture Proteolytic Products. FEBS J. 2020 Jul 03. Razai AS, Snipas SJ, Poreba M, Fasci D, Salvesen GS. PMID: 32619291.
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    2. Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion. Nat Commun. 2020 Jun 23; 11(1):3173. Avrutsky MI, Ortiz CC, Johnson KV, Potenski AM, Chen CW, Lawson JM, White AJ, Yuen SK, Morales FN, Canepa E, Snipas S, Salvesen GS, Jean YY, Troy CM. PMID: 32576823.
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    3. Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11. J Biol Chem. 2020 Jun 18. Bibo-Verdugo B, Snipas SJ, Kolt S, Poreba M, Salvesen GS. PMID: 32554464.
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    4. Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes. J Biol Chem. 2020 May 21. Janiszewski T, Kolt S, Kaiserman D, Snipas SJ, Li S, Kulbacka J, Saczko J, Bovenschen N, Salvesen G, Drag M, Bird PI, Kasperkiewicz P. PMID: 32439802.
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    5. Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy. Proc Natl Acad Sci U S A. 2020 May 05; 117(18):9952-9963. Tom I, Pham VC, Katschke KJ, Li W, Liang WC, Gutierrez J, Ah Young A, Figueroa I, Eshghi ST, Lee CV, Kanodia J, Snipas SJ, Salvesen GS, Lai P, Honigberg L, van Lookeren Campagne M, Kirchhofer D, Baruch A, Lill JR. PMID: 32345717.
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    6. Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe. J Med Chem. 2020 Mar 26; 63(6):3359-3369. Kolt S, Janiszewski T, Kaiserman D, Modrzycka S, Snipas SJ, Salvesen G, Dra G M, Bird PI, Kasperkiewicz P. PMID: 32142286.
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    7. Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. Mol Cell. 2020 03 05; 77(5):927-929. Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi CJ, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemencic M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nyström T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, Ståhlberg J, Suárez MF, Thome M, Tuominen H, Van Breusegem F, van der Hoorn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV. PMID: 32142688.
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    8. Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody. J Biol Chem. 2020 Feb 21; 295(8):2464-2472. Razai AS, Eckelman BP, Salvesen GS. PMID: 31953328.
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    9. Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat Microbiol. 2020 02; 5(2):354-367. Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H. PMID: 31873204.
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    10. The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni. ACS Infect Dis. 2019 10 11; 5(10):1802-1812. Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. PMID: 31355632.
      View in: PubMed   Mentions: 1     Fields:    
    11. Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples. Chem Sci. 2019 Sep 28; 10(36):8461-8477. Poreba M, Groborz K, Vizovisek M, Maruggi M, Turk D, Turk B, Powis G, Drag M, Salvesen GS. PMID: 31803426.
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    12. Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. Cell Rep. 2019 06 18; 27(12):3646-3656.e5. Burgener SS, Leborgne NGF, Snipas SJ, Salvesen GS, Bird PI, Benarafa C. PMID: 31216481.
      View in: PubMed   Mentions: 7     Fields:    
    13. The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1ß Release. J Immunol. 2019 08 01; 203(3):736-748. Rashidi M, Simpson DS, Hempel A, Frank D, Petrie E, Vince A, Feltham R, Murphy J, Chatfield SM, Salvesen GS, Murphy JM, Wicks IP, Vince JE. PMID: 31209100.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells. Cell Death Differ. 2020 Feb; 27(2):451-465. Groborz K, Gonzalez Ramirez ML, Snipas SJ, Salvesen GS, Drag M, Poreba M. PMID: 31209360.
      View in: PubMed   Mentions: 1     Fields:    
    15. Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells. Cell Death Differ. 2019 12; 26(12):2695-2709. Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M. PMID: 30976094.
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    16. Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe. Nanoscale. 2019 Jan 03; 11(2):742-751. Cogo F, Poreba M, Rut W, Groborz K, Smyth P, Johnston MC, Williams R, Longley DB, Burden RE, Salvesen GS, Drag M, Scott CJ. PMID: 30566168.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes. Sci Rep. 2018 10 30; 8(1):15998. Kasperkiewicz P, Kolt S, Janiszewski T, Groborz K, Poreba M, Snipas SJ, Salvesen GS, Drag M. PMID: 30375474.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery. Trends Biochem Sci. 2018 10; 43(10):829-844. Vizovišek M, Vidmar R, Drag M, Fonovic M, Salvesen GS, Turk B. PMID: 30097385.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Caspase selective reagents for diagnosing apoptotic mechanisms. Cell Death Differ. 2019 02; 26(2):229-244. Poreba M, Groborz K, Navarro M, Snipas SJ, Drag M, Salvesen GS. PMID: 29748600.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    20. Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1. J Biol Chem. 2018 05 04; 293(18):7058-7067. Ramirez MLG, Poreba M, Snipas SJ, Groborz K, Drag M, Salvesen GS. PMID: 29414788.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes. Chem Sci. 2018 Feb 28; 9(8):2113-2129. Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M. PMID: 29719685.
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    22. A primer on caspase mechanisms. Semin Cell Dev Biol. 2018 10; 82:79-85. Ramirez MLG, Salvesen GS. PMID: 29329946.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity. Nat Protoc. 2017 Oct; 12(10):2189-2214. Poreba M, Salvesen GS, Drag M. PMID: 28933778.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    24. Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils. J Am Chem Soc. 2017 07 26; 139(29):10115-10125. Kasperkiewicz P, Altman Y, D'Angelo M, Salvesen GS, Drag M. PMID: 28672107.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    25. Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death. Cell Chem Biol. 2017 May 18; 24(5):550-552. Poreba M, Salvesen G. PMID: 28525771.
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    26. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families. Sci Rep. 2017 02 23; 7:43135. Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M. PMID: 28230157.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation. J Immunol. 2017 02 01; 198(3):1066-1080. Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, Rickert RC. PMID: 28031341.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    28. Response to Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML". Sci Signal. 2016 08 09; 9(440):tc2. Fasci D, Anania V, Lill J, Salvesen G. PMID: 27507652.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    29. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016 08 18; 23(8):1023-35. Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M. PMID: 27478158.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia. Sci Transl Med. 2016 05 18; 8(339):339ra69. Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J. PMID: 27194727.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    31. Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom. Toxins (Basel). 2016 Feb 05; 8(2):38. Oroz-Parra I, Navarro M, Cervantes-Luevano KE, Álvarez-Delgado C, Salvesen G, Sanchez-Campos LN, Licea-Navarro AF. PMID: 26861394.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    32. In memoriam: Prof Christopher J Froelich (1951-2015). Cell Death Differ. 2016 Jan; 23(1):3-4. Metkar SS, Pardo J, Anderluh G, Salvesen G, Trapani JA, Simon MM. PMID: 26639556.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Protease signaling in animal and plant-regulated cell death. FEBS J. 2016 07; 283(14):2577-98. Salvesen GS, Hempel A, Coll NS. PMID: 26648190.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. Regulation of Histone Acetylation by Autophagy in Parkinson Disease. J Biol Chem. 2016 Feb 12; 291(7):3531-40. Park G, Tan J, Garcia G, Kang Y, Salvesen G, Zhang Z. PMID: 26699403.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    35. Small Molecule Active Site Directed Tools for Studying Human Caspases. Chem Rev. 2015 Nov 25; 115(22):12546-629. Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M. PMID: 26551511.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi. J Biol Chem. 2015 Nov 20; 290(47):28231-44. Rajkovic J, Poreba M, Caglic D, Vidmar R, Wilk A, Borowik A, Salvesen G, Turk V, Drag M, Turk B. PMID: 26446788.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. The Paracaspase MALT1. Biochimie. 2016 Mar; 122:324-38. Hachmann J, Salvesen GS. PMID: 26386283.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    38. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015 Oct 29; 526(7575):666-71. Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM. PMID: 26375259.
      View in: PubMed   Mentions: 358     Fields:    Translation:HumansAnimalsCells
    39. Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4. PLoS One. 2015; 10(7):e0132818. Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M. PMID: 26172376.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML. Sci Signal. 2015 Jun 09; 8(380):ra56. Fasci D, Anania VG, Lill JR, Salvesen GS. PMID: 26060329.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    41. Probes to monitor activity of the paracaspase MALT1. Chem Biol. 2015 Jan 22; 22(1):139-47. Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen GS. PMID: 25556944.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    42. Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates. PLoS One. 2014; 9(10):e110539. Kumar S, van Raam BJ, Salvesen GS, Cieplak P. PMID: 25330111.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    43. Regulated cell death: signaling and mechanisms. Annu Rev Cell Dev Biol. 2014; 30:337-56. Ashkenazi A, Salvesen G. PMID: 25150011.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    44. Functions of caspase 8: the identified and the mysterious. Semin Immunol. 2014 Jun; 26(3):246-52. Salvesen GS, Walsh CM. PMID: 24856110.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    45. Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates. Cell Death Differ. 2014 Sep; 21(9):1482-92. Poreba M, Kasperkiewicz P, Snipas SJ, Fasci D, Salvesen GS, Drag M. PMID: 24832467.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    46. Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation. J Biol Chem. 2014 May 30; 289(22):15544-53. Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G. PMID: 24713703.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    47. A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids. Amino Acids. 2014 May; 46(5):1313-20. Byzia A, Haeggström JZ, Salvesen GS, Drag M. PMID: 24573245.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    48. Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2518-23. Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen GS, Drag M. PMID: 24550277.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    49. Dying from within: granzyme B converts entosis to emperitosis. Cell Death Differ. 2014 Jan; 21(1):3-4. Salvesen GS. PMID: 24317271.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    50. Caspase enzymology and activation mechanisms. Methods Enzymol. 2014; 544:161-78. Mace PD, Riedl SJ, Salvesen GS. PMID: 24974290.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    51. Caspase substrates and inhibitors. Cold Spring Harb Perspect Biol. 2013 Aug 01; 5(8):a008680. Poreba M, Strózyk A, Salvesen GS, Drag M. PMID: 23788633.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    52. Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. ACS Chem Biol. 2013 Apr 19; 8(4):725-32. Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND. PMID: 23323685.
      View in: PubMed   Mentions: 9     Fields:    
    53. Activity, specificity, and probe design for the smallpox virus protease K7L. J Biol Chem. 2012 Nov 16; 287(47):39470-9. Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS. PMID: 23012361.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    54. Highlight: the universe of proteolytic networks and mechanisms. Biol Chem. 2012 Sep; 393(9):841. Salvesen GS, Bogyo M. PMID: 22944685.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    55. Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6. Cell Death Differ. 2013 Jan; 20(1):86-96. van Raam BJ, Ehrnhoefer DE, Hayden MR, Salvesen GS. PMID: 22858542.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    56. X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP. J Mol Biol. 2012 Sep 28; 422(4):495-507. Sivaraman KK, Oellig CA, Huynh K, Atkinson SC, Poreba M, Perugini MA, Trenholme KR, Gardiner DL, Salvesen G, Drag M, Dalton JP, Whisstock JC, McGowan S. PMID: 22709581.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    57. Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis. J Biol Chem. 2012 Jun 15; 287(25):21142-51. Conus S, Pop C, Snipas SJ, Salvesen GS, Simon HU. PMID: 22528489.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsCTClinical Trials
    58. Mousing around with caspases and IAPs. Biochem J. 2012 Apr 15; 443(2):e1-2. Rickert RC, Salvesen GS, Ware CF. PMID: 22452818.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    59. Mechanism and specificity of the human paracaspase MALT1. Biochem J. 2012 Apr 01; 443(1):287-95. Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS. PMID: 22309193.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
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    61. An optimized activity-based probe for the study of caspase-6 activation. Chem Biol. 2012 Mar 23; 19(3):340-52. Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M. PMID: 22444589.
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    62. Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4904-9. Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR. PMID: 22416118.
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    63. Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. PLoS One. 2012; 7(2):e31938. Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M. PMID: 22359643.
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    64. Glycine fluoromethylketones as SENP-specific activity based probes. Chembiochem. 2012 Jan 02; 13(1):80-4. Dobrota C, Fasci D, Hadade ND, Roiban GD, Pop C, Meier VM, Dumitru I, Matache M, Salvesen GS, Funeriu DP. PMID: 22134988.
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    65. S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors. Biochimie. 2012 Mar; 94(3):704-10. Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen GS, Drag M. PMID: 22085501.
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    66. Snapshot: caspases. Cell. 2011 Oct 14; 147(2):476-476.e1. Salvesen GS, Ashkenazi A. PMID: 22000022.
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    67. RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell. 2011 Oct 07; 44(1):9-16. Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS. PMID: 21981915.
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    68. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15312-7. Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh CM. PMID: 21876153.
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    69. Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. Chem Biol. 2011 Jun 24; 18(6):711-21. Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonovic UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M. PMID: 21700207.
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    70. Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chem Biol. 2011 Jun 24; 18(6):722-32. Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M. PMID: 21700208.
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    71. Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochim Biophys Acta. 2012 Jan; 1824(1):113-22. van Raam BJ, Salvesen GS. PMID: 21704196.
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    72. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. J Neurosci. 2011 Jun 15; 31(24):8894-904. Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH, Salvesen GS, Connolly ES, Troy CM. PMID: 21677173.
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    73. Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. Biochem J. 2011 Apr 15; 435(2):411-20. Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E. PMID: 21314638.
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    74. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature. 2011 Mar 17; 471(7338):363-7. Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. PMID: 21368763.
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    75. FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J. 2011 Feb 01; 433(3):447-457. Pop C, Oberst A, Drag M, Van Raam BJ, Riedl SJ, Green DR, Salvesen GS. PMID: 21235526.
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    76. The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. J Biol Chem. 2011 Mar 25; 286(12):10238-47. Békés M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen GS. PMID: 21247896.
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    77. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1749-50. Petroski MD, Salvesen GS, Wolf DA. PMID: 21245332.
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    78. N-terminomics: a high-content screen for protease substrates and their cleavage sites. Methods Mol Biol. 2011; 753:243-55. Timmer JC, Salvesen GS. PMID: 21604127.
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    79. Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chem Biol. 2010 Nov 24; 17(11):1189-200. Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. PMID: 21095569.
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    80. Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy. 2010 Oct; 6(7):936-47. Shu CW, Drag M, Bekes M, Zhai D, Salvesen GS, Reed JC. PMID: 20818167.
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    81. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature. 2010 Oct 14; 467(7317):863-7. Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS. PMID: 20944749.
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    82. Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci. 2010 Oct 01; 123(Pt 19):3209-14. Bratton SB, Salvesen GS. PMID: 20844150.
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    83. Activation and specificity of human caspase-10. Biochemistry. 2010 Sep 28; 49(38):8307-15. Wachmann K, Pop C, van Raam BJ, Drag M, Mace PD, Snipas SJ, Zmasek C, Schwarzenbacher R, Salvesen GS, Riedl SJ. PMID: 20795673.
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    84. Divide and die another day. Curr Opin Cell Biol. 2010 Dec; 22(6):764-5. Uhlmann F, Salvesen G. PMID: 20864325.
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    85. Distribution and paralogue specificity of mammalian deSUMOylating enzymes. Biochem J. 2010 Sep 01; 430(2):335-44. Kolli N, Mikolajczyk J, Drag M, Mukhopadhyay D, Moffatt N, Dasso M, Salvesen G, Wilkinson KD. PMID: 20590526.
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    86. Emerging principles in protease-based drug discovery. Nat Rev Drug Discov. 2010 Sep; 9(9):690-701. Drag M, Salvesen GS. PMID: 20811381.
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    87. Metacaspases are not caspases--always doubt. Cell Death Differ. 2010 Aug; 17(8):1221. Enoksson M, Salvesen GS. PMID: 20622886.
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    88. Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Mol Cell. 2010 Jul 30; 39(2):184-95. Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR, Lipton SA. PMID: 20670888.
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    89. Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion. Cell Death Differ. 2011 Jan; 18(1):90-8. Leverrier S, Salvesen GS, Walsh CM. PMID: 20523353.
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    90. Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem. 2010 May 28; 285(22):16632-42. Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR. PMID: 20308068.
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    91. Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis. Clin Exp Metastasis. 2010 Apr; 27(4):217-31. Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen GS, Janda KD, Felding-Habermann B. PMID: 20225083.
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    92. Transferring death: a role for tRNA in apoptosis regulation. Mol Cell. 2010 Mar 12; 37(5):591-2. van Raam BJ, Salvesen GS. PMID: 20227362.
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    93. Identification of very potent inhibitor of human aminopeptidase N (CD13). Bioorg Med Chem Lett. 2010 Apr 15; 20(8):2497-9. Grzywa R, Oleksyszyn J, Salvesen GS, Drag M. PMID: 20307982.
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    94. Vaccinia virus protein F1L is a caspase-9 inhibitor. J Biol Chem. 2010 Feb 19; 285(8):5569-80. Zhai D, Yu E, Jin C, Welsh K, Shiau CW, Chen L, Salvesen GS, Liddington R, Reed JC. PMID: 20022954.
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    95. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J. 2009 Dec 10; 424(3):335-45. Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC. PMID: 19788411.
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    96. Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. J Biol Chem. 2010 Jan 29; 285(5):3310-8. Drag M, Bogyo M, Ellman JA, Salvesen GS. PMID: 19948737.
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    97. Structural and kinetic determinants of protease substrates. Nat Struct Mol Biol. 2009 Oct; 16(10):1101-8. Timmer JC, Zhu W, Pop C, Regan T, Snipas SJ, Eroshkin AM, Riedl SJ, Salvesen GS. PMID: 19767749.
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    98. Structure of the Fas/FADD complex: a conditional death domain complex mediating signaling by receptor clustering. Cell Cycle. 2009 Sep 01; 8(17):2723-7. Salvesen GS, Riedl SJ. PMID: 19652545.
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    99. Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells. 2009 Aug; 27(8):1772-81. Cimadamore F, Curchoe CL, Alderson N, Scott F, Salvesen G, Terskikh AV. PMID: 19544437.
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    100. Human caspases: activation, specificity, and regulation. J Biol Chem. 2009 Aug 14; 284(33):21777-81. Pop C, Salvesen GS. PMID: 19473994.
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    101. The CULt of caspase-8 ubiquitination. Cell. 2009 May 15; 137(4):604-6. Békés M, Salvesen GS. PMID: 19450509.
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    102. Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. Mol Cell. 2009 Mar 13; 33(5):570-80. Zhu S, Goeres J, Sixt KM, Békés M, Zhang XD, Salvesen GS, Matunis MJ. PMID: 19285941.
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    103. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature. 2009 Feb 19; 457(7232):1019-22. Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, Robinson H, Salvesen GS, Schwarzenbacher R, Riedl SJ. PMID: 19118384.
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    104. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. PMID: 19001420.
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    105. DeSUMOylating enzymes--SENPs. IUBMB Life. 2008 Nov; 60(11):734-42. Drag M, Salvesen GS. PMID: 18666185.
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    106. Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes). Biochem J. 2008 Nov 01; 415(3):367-75. Drag M, Mikolajczyk J, Bekes M, Reyes-Turcu FE, Ellman JA, Wilkinson KD, Salvesen GS. PMID: 18601651.
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    107. Proteolytic needles in the cellular haystack. Nat Chem Biol. 2008 Nov; 4(11):651-2. Enoksson M, Salvesen GS. PMID: 18936746.
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    108. Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem. 2008 Jul 04; 283(27):19140-50. Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V, Turk B. PMID: 18469004.
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    109. Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem. 2008 Jul 11; 283(28):19499-510. Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, Salvesen GS. PMID: 18458084.
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    110. Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC. Cell Death Differ. 2008 May; 15(5):938-45. Snipas SJ, Drag M, Stennicke HR, Salvesen GS. PMID: 18309328.
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    111. The mechanism of peptide-binding specificity of IAP BIR domains. Cell Death Differ. 2008 May; 15(5):920-8. Eckelman BP, Drag M, Snipas SJ, Salvesen GS. PMID: 18239672.
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    112. Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. Biochem J. 2008 Jan 15; 409(2):461-9. Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS. PMID: 17916063.
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    113. Caspase mechanisms. Adv Exp Med Biol. 2008; 615:13-23. Salvesen GS, Riedl SJ. PMID: 18437889.
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    114. Caspase assays: identifying caspase activity and substrates in vitro and in vivo. Methods Enzymol. 2008; 446:351-67. Pop C, Salvesen GS, Scott FL. PMID: 18603133.
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    115. Apoptotic caspase activation and activity. Methods Mol Biol. 2008; 414:191-220. Denault JB, Salvesen GS. PMID: 18175821.
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    116. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ. 2008 Feb; 15(2):322-31. McStay GP, Salvesen GS, Green DR. PMID: 17975551.
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    117. Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking. Biochem J. 2007 Oct 15; 407(2):171-7. Wu YI, Munshi HG, Snipas SJ, Salvesen GS, Fridman R, Stack MS. PMID: 17650075.
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    118. Profiling constitutive proteolytic events in vivo. Biochem J. 2007 Oct 01; 407(1):41-8. Timmer JC, Enoksson M, Wildfang E, Zhu W, Igarashi Y, Denault JB, Ma Y, Dummitt B, Chang YH, Mast AE, Eroshkin A, Smith JW, Tao WA, Salvesen GS. PMID: 17650073.
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    119. Small molecules not direct activators of caspases. Nat Chem Biol. 2007 Sep; 3(9):519; author reply 520. Denault JB, Drag M, Salvesen GS, Alves J, Heidt AB, Deveraux Q, Harris JL. PMID: 17710090.
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    120. Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells. J Biol Chem. 2007 Oct 12; 282(41):30216-26. Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A. PMID: 17681953.
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    121. Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J. 2007 Jul 01; 405(1):11-9. Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS. PMID: 17437405.
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    122. Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. J Biol Chem. 2007 Sep 07; 282(36):26217-24. Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS. PMID: 17591783.
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    123. Identification of proteolytic cleavage sites by quantitative proteomics. J Proteome Res. 2007 Jul; 6(7):2850-8. Enoksson M, Li J, Ivancic MM, Timmer JC, Wildfang E, Eroshkin A, Salvesen GS, Tao WA. PMID: 17547438.
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    124. Caspase inhibition, specifically. Structure. 2007 May; 15(5):513-4. Salvesen GS, Riedl SJ. PMID: 17502096.
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    125. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol. 2007 May; 8(5):405-13. Riedl SJ, Salvesen GS. PMID: 17377525.
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    126. Role of proteolysis in caspase-8 activation and stabilization. Biochemistry. 2007 Apr 10; 46(14):4398-407. Pop C, Fitzgerald P, Green DR, Salvesen GS. PMID: 17371051.
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    127. Caspase substrates. Cell Death Differ. 2007 Jan; 14(1):66-72. Timmer JC, Salvesen GS. PMID: 17082814.
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    128. Cytokine response modifier a inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer. J Biol Chem. 2006 Dec 15; 281(50):38781-90. Dobó J, Swanson R, Salvesen GS, Olson ST, Gettins PG. PMID: 17052983.
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    129. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep. 2006 Oct; 7(10):988-94. Eckelman BP, Salvesen GS, Scott FL. PMID: 17016456.
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    130. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. J Med Chem. 2006 Sep 21; 49(19):5728-49. Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen GS, Ganesan R, Jelakovic S, Grütter MG, Powers JC. PMID: 16970398.
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    131. Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell. 2006 Aug; 23(4):509-21. Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M. PMID: 16916639.
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    132. Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol Cell. 2006 Aug; 23(4):523-33. Denault JB, Békés M, Scott FL, Sexton KM, Bogyo M, Salvesen GS. PMID: 16916640.
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    133. The apoptosome activates caspase-9 by dimerization. Mol Cell. 2006 Apr 21; 22(2):269-75. Pop C, Timmer J, Sperandio S, Salvesen GS. PMID: 16630894.
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    134. Chemical ligation--an unusual paradigm in protease inhibition. Mol Cell. 2006 Mar 17; 21(6):727-8. Stennicke HR, Salvesen GS. PMID: 16543139.
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    135. The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem. 2006 Feb 10; 281(6):3254-60. Eckelman BP, Salvesen GS. PMID: 16339151.
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    136. The nematode death machine in 3D. Cell. 2005 Oct 21; 123(2):192-3. Pop C, Salvesen GS. PMID: 16239138.
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    137. Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions. Arch Biochem Biophys. 2005 Aug 01; 440(1):1-9. Simonovic M, Denault JB, Salvesen GS, Volz K, Gettins PG. PMID: 15993378.
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    138. Activity-based probes that target diverse cysteine protease families. Nat Chem Biol. 2005 Jun; 1(1):33-8. Kato D, Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, Chehade KA, Salvesen GS, Bogyo M. PMID: 16407991.
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    139. A novel caspase-7 specific monoclonal antibody. Immunol Lett. 2005 Apr 15; 98(1):167-9. Gregorc U, Dobersek A, Salvesen GS, Turk V, Turk B, Kopitar-Jerala N. PMID: 15849872.
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    140. XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J. 2005 Feb 09; 24(3):645-55. Scott FL, Denault JB, Riedl SJ, Shin H, Renatus M, Salvesen GS. PMID: 15650747.
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    141. Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells. J Biol Chem. 2005 Mar 18; 280(11):10388-94. Bruckner S, Rhamouni S, Tautz L, Denault JB, Alonso A, Becattini B, Salvesen GS, Mustelin T. PMID: 15632192.
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    142. The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. Biochem J. 2005 Jan 01; 385(Pt 1):1-10. Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS. PMID: 15485395.
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    143. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 01; 385(Pt 1):11-20. Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. PMID: 15485396.
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    144. The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J. 2004 Dec 01; 384(Pt 2):201-32. Fuentes-Prior P, Salvesen GS. PMID: 15450003.
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    145. Characteristics of the caspase-like catalytic domain of human paracaspase. Biol Chem. 2004 Nov; 385(11):1093-8. Snipas SJ, Wildfang E, Nazif T, Christensen L, Boatright KM, Bogyo M, Stennicke HR, Salvesen GS. PMID: 15576331.
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    146. Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Exp Neurol. 2004 Oct; 189(2):261-79. Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S. PMID: 15380478.
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    147. Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J Biol Chem. 2004 Dec 03; 279(49):51082-90. Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS, Duckett CS. PMID: 15371416.
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    148. Activation of caspases-8 and -10 by FLIP(L). Biochem J. 2004 Sep 01; 382(Pt 2):651-7. Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS. PMID: 15209560.
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    149. Activation and substrate specificity of caspase-14. Biochemistry. 2004 Aug 17; 43(32):10560-9. Mikolajczyk J, Scott FL, Krajewski S, Sutherlin DP, Salvesen GS. PMID: 15301553.
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    150. An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13; 279(33):34087-90. Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC. PMID: 15218035.
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    151. Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies. Oncogene. 2004 Apr 12; 23(16):2774-84. Salvesen GS, Abrams JM. PMID: 15077141.
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    152. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 08; 47(8):1889-92. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. PMID: 15055989.
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    153. Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8. J Med Chem. 2004 Mar 11; 47(6):1553-74. James KE, Asgian JL, Li ZZ, Ekici OD, Rubin JR, Mikolajczyk J, Salvesen GS, Powers JC. PMID: 14998341.
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    154. Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. Blood. 2004 Aug 15; 104(4):932. Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC. PMID: 14739219.
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    155. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell. 2004 Jan; 5(1):25-35. Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC. PMID: 14749124.
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    156. Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. J Biol Chem. 2004 Feb 27; 279(9):8278-89. Wu YI, Munshi HG, Sen R, Snipas SJ, Salvesen GS, Fridman R, Stack MS. PMID: 14670950.
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    157. Mechanisms of caspase activation. Curr Opin Cell Biol. 2003 Dec; 15(6):725-31. Boatright KM, Salvesen GS. PMID: 14644197.
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    158. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem. 2004 Jan 30; 279(5):3578-87. Cirman T, Oresic K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B. PMID: 14581476.
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    159. Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. Biochem J. 2003 Aug 01; 373(Pt 3):965-71. Shin H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen GS. PMID: 12747801.
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    160. XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells. J Exp Med. 2003 Jul 21; 198(2):341-7. Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier JM. PMID: 12874265.
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    161. Human caspase-7 activity and regulation by its N-terminal peptide. J Biol Chem. 2003 Sep 05; 278(36):34042-50. Denault JB, Salvesen GS. PMID: 12824163.
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    162. Caspases and neuronal development. Biol Chem. 2003 Jun; 384(6):855-61. Ryan CA, Salvesen GS. PMID: 12887052.
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    163. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun; 13(6B):1376-88. Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A. PMID: 12819136.
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    164. Serpins are getting hotter. Structure. 2003 Apr; 11(4):364-5. Salvesen GS, Scott FL. PMID: 12679013.
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    165. A unified model for apical caspase activation. Mol Cell. 2003 Feb; 11(2):529-41. Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS. PMID: 12620239.
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    166. Expression, purification, and characterization of caspases. Curr Protoc Protein Sci. 2003 Feb; Chapter 21:Unit 21.13. Denault JB, Salvesen GS. PMID: 18429241.
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    167. Sequential autolytic processing activates the zymogen of Arg-gingipain. J Biol Chem. 2003 Mar 21; 278(12):10458-64. Mikolajczyk J, Boatright KM, Stennicke HR, Nazif T, Potempa J, Bogyo M, Salvesen GS. PMID: 12533545.
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    168. A tribute to Alan J. Barrett. Biochem Soc Symp. 2003; (70):ix-x. Saklatvala J, Nagase H, Salvesen G. PMID: 14587277.
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    169. Caspase activation. Biochem Soc Symp. 2003; (70):233-42. Boatright KM, Salvesen GS. PMID: 14587296.
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    170. Caspases: keys in the ignition of cell death. Chem Rev. 2002 Dec; 102(12):4489-500. Denault JB, Salvesen GS. PMID: 12475198.
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    171. Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases. J Med Chem. 2002 Nov 07; 45(23):4958-60. Asgian JL, James KE, Li ZZ, Carter W, Barrett AJ, Mikolajczyk J, Salvesen GS, Powers JC. PMID: 12408706.
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    172. Inhibitor specificity of recombinant and endogenous caspase-9. Biochem J. 2002 Sep 01; 366(Pt 2):595-601. Ryan CA, Stennicke HR, Nava VE, Burch JB, Hardwick JM, Salvesen GS. PMID: 12067274.
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    173. Caspases on the brain. J Neurosci Res. 2002 Jul 15; 69(2):145-50. Troy CM, Salvesen GS. PMID: 12111795.
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    174. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 2002 Jun; 3(6):401-10. Salvesen GS, Duckett CS. PMID: 12042762.
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    175. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26; 277(30):27217-26. Gil-Parrado S, Fernández-Montalván A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W. PMID: 12000759.
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    176. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3974-9. Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA. PMID: 11904443.
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    177. Apoptosome: the seven-spoked death machine. Dev Cell. 2002 Mar; 2(3):256-7. Salvesen GS, Renatus M. PMID: 11879630.
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    178. Reprieval from execution: the molecular basis of caspase inhibition. Trends Biochem Sci. 2002 Feb; 27(2):94-101. Stennicke HR, Ryan CA, Salvesen GS. PMID: 11852247.
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    179. Caspases. Curr Protoc Protein Sci. 2002 Feb; Chapter 21:Unit 21.8. Denault JB, Salvesen GS. PMID: 18429233.
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    180. Caspases and apoptosis. Essays Biochem. 2002; 38:9-19. Salvesen GS. PMID: 12463158.
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    181. Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators. Curr Pharm Des. 2002; 8(18):1623-37. Turk B, Turk D, Salvesen GS. PMID: 12132995.
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    182. Caspases: opening the boxes and interpreting the arrows. Cell Death Differ. 2002 Jan; 9(1):3-5. Salvesen GS. PMID: 11803369.
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    183. Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death. Neuromolecular Med. 2002; 1(1):69-79. Lu C, Fu W, Salvesen GS, Mattson MP. PMID: 12025817.
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    184. Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):14790-5. Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W. PMID: 11752425.
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    185. Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14250-5. Renatus M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS. PMID: 11734640.
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    186. Mechanism-based inactivation of caspases by the apoptotic suppressor p35. Biochemistry. 2001 Nov 06; 40(44):13274-80. Riedl SJ, Renatus M, Snipas SJ, Salvesen GS. PMID: 11683637.
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    187. Inhibition of distant caspase homologues by natural caspase inhibitors. Biochem J. 2001 Jul 15; 357(Pt 2):575-80. Snipas SJ, Stennicke HR, Riedl S, Potempa J, Travis J, Barrett AJ, Salvesen GS. PMID: 11439111.
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    188. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem. 2001 Sep 07; 276(36):33293-6. Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. PMID: 11435447.
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    189. Structural basis for the inhibition of caspase-3 by XIAP. Cell. 2001 Mar 09; 104(5):791-800. Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS. PMID: 11257232.
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    190. A lysosomal protease enters the death scene. J Clin Invest. 2001 Jan; 107(1):21-2. Salvesen GS. PMID: 11134173.
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    191. Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis. Adv Enzyme Regul. 2001; 41:237-50. Katunuma N, Matsui A, Le QT, Utsumi K, Salvesen G, Ohashi A. PMID: 11384748.
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    192. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. J Biol Chem. 2001 Mar 16; 276(11):8087-93. Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC. PMID: 11098060.
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    193. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem. 2001 Feb 02; 276(5):3149-57. Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS. PMID: 11073962.
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    194. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol. 2000 Nov 02; 10(21):1359-66. Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM. PMID: 11084335.
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    195. Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis. J Biol Chem. 2001 Jan 26; 276(4):2935-42. Affar EB, Germain M, Winstall E, Vodenicharov M, Shah RG, Salvesen GS, Poirier GG. PMID: 11053413.
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    196. Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem J. 2000 Sep 01; 350 Pt 2:563-8. Stennicke HR, Renatus M, Meldal M, Salvesen GS. PMID: 10947972.
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    197. Crystal structure of the apoptotic suppressor CrmA in its cleaved form. Structure. 2000 Jul 15; 8(7):789-97. Renatus M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA, Liddington RC, Salvesen GS. PMID: 10903953.
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    198. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med. 2000 Apr; 6(4):397-404. Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. PMID: 10742146.
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    199. Caspases - controlling intracellular signals by protease zymogen activation. Biochim Biophys Acta. 2000 Mar 07; 1477(1-2):299-306. Stennicke HR, Salvesen GS. PMID: 10708865.
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    200. Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1427-32. Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC. PMID: 10677478.
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    201. Caspase assays. Methods Enzymol. 2000; 322:91-100. Stennicke HR, Salvesen GS. PMID: 10914007.
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    202. Viral caspase inhibitors CrmA and p35. Methods Enzymol. 2000; 322:143-54. Zhou Q, Salvesen GS. PMID: 10914011.
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    203. Catalytic properties of the caspases. Cell Death Differ. 1999 Nov; 6(11):1054-9. Stennicke HR, Salvesen GS. PMID: 10578173.
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    204. Endogenous inhibitors of caspases. J Clin Immunol. 1999 Nov; 19(6):388-98. Deveraux QL, Stennicke HR, Salvesen GS, Reed JC. PMID: 10634212.
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    205. Caspase 8: igniting the death machine. Structure. 1999 Oct 15; 7(10):R225-9. Salvesen GS. PMID: 10545333.
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    206. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem. 1999 Oct 01; 274(40):28379-84. Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, Poirier GG. PMID: 10497198.
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    207. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 1999 Oct 01; 18(19):5242-51. Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC. PMID: 10508158.
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    209. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood. 1999 Sep 01; 94(5):1683-92. Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen GS, Green DR. PMID: 10477693.
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    210. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5752-7. Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. PMID: 10318956.
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    212. Caspase-9 can be activated without proteolytic processing. J Biol Chem. 1999 Mar 26; 274(13):8359-62. Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS. PMID: 10085063.
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    213. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. J Biol Chem. 1999 Mar 26; 274(13):8730-6. Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. PMID: 10085113.
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    214. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell. 1999 Mar 05; 96(5):615-24. Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G. PMID: 10089877.
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    215. Programmed cell death and the caspases. APMIS. 1999 Jan; 107(1):73-9. Salvesen GS. PMID: 10190282.
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    216. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem. 1999 Jan; 72(1):185-95. Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. PMID: 9886069.
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    217. Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem. 1998 Dec 18; 273(51):34278-83. Yang X, Stennicke HR, Wang B, Green DR, Jänicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ. PMID: 9852092.
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    218. Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3. Cell Death Differ. 1998 Dec; 5(12):1034-41. Miyashita T, Nagao K, Krajewski S, Salvesen GS, Reed JC, Inoue T, Yamada M. PMID: 9894610.
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    219. Regulation of cell death protease caspase-9 by phosphorylation. Science. 1998 Nov 13; 282(5392):1318-21. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. PMID: 9812896.
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    220. Caspase-14 is a novel developmentally regulated protease. J Biol Chem. 1998 Nov 06; 273(45):29648-53. Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. PMID: 9792675.
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    221. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature. 1998 Oct 22; 395(6704):801-4. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE. PMID: 9796814.
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    222. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 1998 Oct 16; 273(42):27084-90. Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS. PMID: 9765224.
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    223. Properties of the caspases. Biochim Biophys Acta. 1998 Sep 08; 1387(1-2):17-31. Stennicke HR, Salvesen GS. PMID: 9748481.
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    224. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry. 1998 Jul 28; 37(30):10757-65. Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS. PMID: 9692966.
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    225. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15; 17(8):2215-23. Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC. PMID: 9545235.
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    226. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem. 1998 Apr 10; 273(15):9158-67. Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. PMID: 9535906.
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    227. A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem. 1998 Apr 03; 273(14):7787-90. Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen GS, Reed JC. PMID: 9525868.
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    228. Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell Death Differ. 1998 Apr; 5(4):298-306. Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR. PMID: 10200475.
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    229. Granzyme release and caspase activation in activated human T-lymphocytes. J Biol Chem. 1998 Mar 20; 273(12):6916-20. Zapata JM, Takahashi R, Salvesen GS, Reed JC. PMID: 9506996.
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    230. An induced proximity model for caspase-8 activation. J Biol Chem. 1998 Jan 30; 273(5):2926-30. Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. PMID: 9446604.
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    231. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1997 Dec 01; 16(23):6914-25. Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. PMID: 9384571.
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    232. Caspases: intracellular signaling by proteolysis. Cell. 1997 Nov 14; 91(4):443-6. Salvesen GS, Dixit VM. PMID: 9390553.
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    234. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol. 1997 Sep 22; 138(6):1379-94. Caulín C, Salvesen GS, Oshima RG. PMID: 9298992.
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    235. Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases. J Neurosci. 1997 Aug 15; 17(16):6165-78. Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS, Casiano CA, Cashman NR, Green DR, Bredesen DE. PMID: 9236228.
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    236. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell. 1997 Jul 25; 90(2):315-23. Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM. PMID: 9244305.
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    237. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem. 1997 Jul 25; 272(30):18530-3. Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA. PMID: 9228015.
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    238. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997 Jul 17; 388(6639):300-4. Deveraux QL, Takahashi R, Salvesen GS, Reed JC. PMID: 9230442.
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    239. Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. Biochem J. 1997 Jun 01; 324 ( Pt 2):361-4. Zhou Q, Salvesen GS. PMID: 9182691.
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    240. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem. 1997 Mar 21; 272(12):7797-800. Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS. PMID: 9065443.
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    241. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem. 1997 Jan 31; 272(5):2952-6. Muzio M, Salvesen GS, Dixit VM. PMID: 9006941.
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    242. Serpins and programmed cell death. Adv Exp Med Biol. 1997; 425:177-83. Salvesen GS. PMID: 9433500.
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    243. Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy. Protein Sci. 1996 Nov; 5(11):2226-35. Koloczek H, Banbula A, Salvesen GS, Potempa J. PMID: 8931141.
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    244. Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun. 1996 Oct 23; 227(3):658-65. Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, D'Amours D, Salvesen GS, Alnemri ES, Earnshaw WC, Shah GM. PMID: 8885990.
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    245. Human ICE/CED-3 protease nomenclature. Cell. 1996 Oct 18; 87(2):171. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J. PMID: 8861900.
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    246. Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J Biol Chem. 1996 Aug 30; 271(35):20977-80. Orth K, O'Rourke K, Salvesen GS, Dixit VM. PMID: 8702858.
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    247. Interaction of subtilisins with serpins. Protein Sci. 1996 May; 5(5):874-82. Komiyama T, Grøn H, Pemberton PA, Salvesen GS. PMID: 8732759.
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    248. Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):1972-6. Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup DJ, Salvesen GS. PMID: 8700869.
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    249. Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA. Adv Exp Med Biol. 1996; 389:173-6. Komiyama T, Quan LT, Salvesen GS. PMID: 8861008.
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    250. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 1995 Jun 02; 81(5):801-9. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM. PMID: 7774019.
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    251. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J Biol Chem. 1995 May 05; 270(18):10377-9. Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GS. PMID: 7737968.
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    252. Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma. Biochem J. 1994 Aug 01; 301 ( Pt 3):745-51. Falkenberg C, Enghild JJ, Thøgersen IB, Salvesen G, Akerström B. PMID: 7519849.
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    253. Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J Biol Chem. 1994 Jul 29; 269(30):19331-7. Komiyama T, Ray CA, Pickup DJ, Howard AD, Thornberry NA, Peterson EP, Salvesen G. PMID: 8034697.
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    254. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):8098-102. Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. PMID: 8367470.
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    256. Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. J Biol Chem. 1993 Apr 25; 268(12):8711-6. Enghild JJ, Salvesen G, Thøgersen IB, Valnickova Z, Pizzo SV, Hefta SA. PMID: 7682553.
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    257. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):1977-81. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD. PMID: 8446617.
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    258. alpha-Macroglobulins: detection and characterization. Methods Enzymol. 1993; 223:121-41. Salvesen G, Enghild JJ. PMID: 7505874.
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    259. Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli. FEBS Lett. 1992 Nov 23; 313(2):198-202. Salvesen G, Quan LT, Enghild JJ, Snipas S, Fey GH, Pizzo SV. PMID: 1385222.
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    260. Purification and characterization of an alpha-macroglobulin proteinase inhibitor from the mollusc Octopus vulgaris. Biochem J. 1992 Jul 15; 285 ( Pt 2):521-7. Thøgersen IB, Salvesen G, Brucato FH, Pizzo SV, Enghild JJ. PMID: 1379044.
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    261. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell. 1992 May 15; 69(4):597-604. Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, Pickup DJ. PMID: 1339309.
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    263. Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3. Matrix Suppl. 1992; 1:237-44. Nagase H, Suzuki K, Morodomi T, Enghild JJ, Salvesen G. PMID: 1480033.
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    264. Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). J Biol Chem. 1991 Aug 25; 266(24):15810-6. Mast AE, Enghild JJ, Nagase H, Suzuki K, Pizzo SV, Salvesen G. PMID: 1651920.
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    272. Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system. Biochemistry. 1990 Oct 30; 29(43):10070-80. Enghild JJ, Thøgersen IB, Salvesen G, Fey GH, Figler NL, Gonias SL, Pizzo SV. PMID: 1703001.
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    285. Molecular cloning of human neutrophil elastase. Biol Chem Hoppe Seyler. 1988 May; 369 Suppl:3-7. Farley D, Salvesen G, Travis J. PMID: 2462434.
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    286. Human kininogens. Methods Enzymol. 1988; 163:240-56. Müller-Esterl W, Johnson DA, Salvesen G, Barrett AJ. PMID: 3237076.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    287. Neutrophil elastase and cathepsin G: structure, function, and biological control. Adv Exp Med Biol. 1988; 240:23-31. Watorek W, Farley D, Salvesen G, Travis J. PMID: 3266707.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    288. Rapid isolation of human kininogens. Thromb Res. 1987 Oct 15; 48(2):187-93. Johnson DA, Salvesen G, Brown MA, Barrett AJ. PMID: 3122358.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    289. Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. Biochemistry. 1987 Apr 21; 26(8):2289-93. Salvesen G, Farley D, Shuman J, Przybyla A, Reilly C, Travis J. PMID: 3304423.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    290. Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J Biol Chem. 1986 Aug 25; 261(24):11282-9. Abrahamson M, Barrett AJ, Salvesen G, Grubb A. PMID: 3488317.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    291. Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases. Biochem J. 1986 Mar 01; 234(2):429-34. Salvesen G, Parkes C, Abrahamson M, Grubb A, Barrett AJ. PMID: 3521586.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    292. Primary structure of the reactive site of human C1-inhibitor. J Biol Chem. 1985 Feb 25; 260(4):2432-6. Salvesen GS, Catanese JJ, Kress LF, Travis J. PMID: 3919001.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    293. Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region. Hoppe Seylers Z Physiol Chem. 1983 Sep; 364(9):1297-302. Virca GD, Salvesen GS, Travis J. PMID: 6195065.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    294. Control of coagulation and fibrinolysis by plasma proteinase inhibitors. Behring Inst Mitt. 1983 Aug; (73):56-65. Travis J, Salvesen G. PMID: 6206838.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    295. Interaction of alpha 2-macroglobulin with neutrophil and plasma proteinases. Ann N Y Acad Sci. 1983; 421:316-26. Salvesen G, Virca GD, Travis J. PMID: 6202199.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    296. Human plasma proteinase inhibitors. Annu Rev Biochem. 1983; 52:655-709. Travis J, Salvesen GS. PMID: 6193754.
      View in: PubMed   Mentions: 295     Fields:    Translation:HumansAnimalsCells
    297. Interaction of plasma kallikrein with plasma proteinase inhibitors. Adv Exp Med Biol. 1983; 156:121-30. Salvesen G, Virca GD, Travis J. PMID: 6190363.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    298. Further characterization of the covalent linking reaction of alpha 2-macroglobulin. Biochem J. 1981 May 01; 195(2):453-61. Salvesen GS, Sayers CA, Barrett AJ. PMID: 6172116.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    299. Covalent binding of proteinases in their reaction with alpha 2-macroglobulin. Biochem J. 1980 Jun 01; 187(3):695-701. Salvesen GS, Barrett AJ. PMID: 6204637.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
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