Lawrence Liu

Home
About
Help/FAQs
Search Options
- UC Davis
- UCI
- UCLA
- UCSD
- UCSF
- All UC Health
- USC
- All
- Find People
- Find Everything

Title(s)	Postdoctoral Scholar, Pharmacology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
vCard	Download vCard

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates. Protein Sci. 2025 Jun; 34(6):e70180. Silva EB, Jiang Z, Liu C, Fajtová P, Teixeira TR, de Castro Fiorini Maia G, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ. PMID: 40411405; PMCID: PMC12102734.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Humans Animals
An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4. J Biol Chem. 2025 Mar; 301(3):108275. Bhaduri S, Braza MKE, Stanchev S, Tauber M, Al-Bawab R, Liu LJ, Trujillo DF, Solorio-Kirpichyan K, Srivastava A, Sanlley-Hernandez J, O'Donoghue AJ, Lemberg MK, Amaro R, Strisovsky K, Neal SE. PMID: 39922490; PMCID: PMC11929074.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Humans Cells
Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome. Protein Sci. 2024 Dec; 33(12):e5225. Fajtova P, Hurysz BM, Miyamoto Y, Serafim MSM, Jiang Z, Vazquez JM, Trujillo DF, Liu LJ, Somani U, Almaliti J, Myers SA, Caffrey CR, Gerwick WH, McMinn DL, Kirk CJ, Boura E, Eckmann L, O'Donoghue AJ. PMID: 39589076; PMCID: PMC11590128.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Animals Cells
Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship and In Vivo Efficacy. ACS Infect Dis. 2024 Dec 13; 10(12):4182-4193. Liu LJ, Francisco KR, Sun YU, Serafim MSM, Amarasinghe DK, Teixeira TR, Lucero B, Kronenberger T, Elsayed W, Elwakeel H, Al-Hindy M, Almaliti J, Gerwick WH, O'Donoghue AJ, Caffrey CR. PMID: 39589805; PMCID: PMC11650654.

View in: PubMed Mentions: 2 Fields:
Ant Anti-Infective Agents Dru Drug Therapy Mic Microbiology
Translation:Humans Animals
Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities. Results Chem. 2024 Dec; 12. Dawoodjee AM, Sichinga J, Banda H, Mbaya S, Funjika E, Mayoka G, Hikaambo C, Francisco KR, Sun YU, Liu LJ, Caffrey CR, Cheuka PM. PMID: 40129570; PMCID: PMC11932705.

View in: PubMed Mentions:
An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4. bioRxiv. 2024 Oct 17. Bhaduri S, Braza MKE, Stanchev S, Tauber M, Al-Bawab R, Liu LJ, Trujillo DF, Solorio-Kirpichyan K, Srivastava A, Sanlley-Hernandez J, O'Donoghue AJ, Lemberg MK, Amario R, Strisovsky K, Neal SE. PMID: 39415989; PMCID: PMC11483055.

View in: PubMed Mentions:
The proteasome as a drug target for treatment of parasitic diseases. Adv Parasitol. 2024; 126:53-96. Liu LJ, O'Donoghue AJ, Caffrey CR. PMID: 39448194.

View in: PubMed Mentions: 2 Fields:
Par Parasitology
Translation:Humans Animals
Clickable Probes for Pathogen Proteasomes: Synthesis and Applications. ACS Omega. 2024 Aug 13; 9(32):34829-34840. Liu LJ, Lucero B, Manriquez-Rodriguez C, Francisco KR, Teixeira TR, Yohannan DJ, Ballatore C, Myers SA, O'Donoghue AJ, Caffrey CR. PMID: 39157084; PMCID: PMC11325529.

View in: PubMed Mentions: 1
Pharmacophore Virtual Screening Identifies Riboflavin as an Inhibitor of the Schistosome Cathepsin B1 Protease with Antiparasitic Activity. ACS Omega. 2024 Jun 11; 9(23):25356-25369. Cogo RM, Pavani TFA, Mengarda ACA, Cajas RA, Teixeira TR, Fukui-Silva L, Sun YU, Liu LJ, Amarasinghe DK, Yoon MC, Santos-Filho OA, de Moraes J, Caffrey CR, G G Rando D. PMID: 38882094; PMCID: PMC11170711.

View in: PubMed Mentions: 1
Development of subunit selective proteasome substrates for Schistosoma species. bioRxiv. 2024 Feb 14. Jiang Z, Silva EB, Liu C, Fajtová P, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ. PMID: 38405969; PMCID: PMC10888821.

View in: PubMed Mentions:
Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies. ChemMedChem. 2024 04 16; 19(8):e202300656. Lucero B, Francisco KR, Varricchio C, Liu LJ, Yao Y, Brancale A, Brunden KR, Caffrey CR, Ballatore C. PMID: 38277231; PMCID: PMC11031298.

View in: PubMed Mentions: 1 Fields:
Che Chemistry Pha Pharmacology
Translation:Humans Animals Cells
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis. ChemMedChem. 2023 10 17; 18(20):e202300193. Monti L, Liu LJ, Varricchio C, Lucero B, Alle T, Yang W, Bem-Shalom I, Gilson M, Brunden KR, Brancale A, Caffrey CR, Ballatore C. PMID: 37429821; PMCID: PMC10615688.

View in: PubMed Mentions: 4 Fields:
Che Chemistry Pha Pharmacology
Translation:Humans Animals Cells
Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron. Nat Chem Biol. 2023 Dec; 19(12):1469-1479. Keller LJ, Nguyen TH, Liu LJ, Hurysz BM, Lakemeyer M, Guerra M, Gelsinger DJ, Chanin R, Ngo N, Lum KM, Faucher F, Ipock P, Niphakis MJ, Bhatt AS, O'Donoghue AJ, Huang KC, Bogyo M. PMID: 37349583.

View in: PubMed Mentions: 12 Fields:
Bio Biology Che Chemistry
Translation:Humans Cells
Protein-protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies. Trends Pharmacol Sci. 2023 07; 44(7):474-488. Lucero B, Francisco KR, Liu LJ, Caffrey CR, Ballatore C. PMID: 37263826; PMCID: PMC11003449.

View in: PubMed Mentions: 11 Fields:
Pha Pharmacology
Translation:Humans Cells
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5- a ]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis. bioRxiv. 2023 Mar 11. Monti L, Liu LJ, Varricchio C, Lucero B, Alle T, Yang W, Bem-Shalom I, Gilson M, Brunden KR, Brancale A, Caffrey CR, Ballatore C. PMID: 36945407; PMCID: PMC10028969.

View in: PubMed Mentions:
Activity of N-phenylbenzamide analogs against the neglected disease pathogen, Schistosoma mansoni. Bioorg Med Chem Lett. 2023 02 15; 82:129164. Kanyanta M, Lengwe C, Mambwe D, Francisco KR, Liu LJ, Uli Sun Y, Amarasinghe DK, Caffrey CR, Mubanga Cheuka P. PMID: 36736493; PMCID: PMC10072318.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei. Bioorg Med Chem Lett. 2023 02 01; 81:129123. Francisco KR, Monti L, Yang W, Park H, Liu LJ, Watkins K, Amarasinghe DK, Nalli M, Roberto Polaquini C, Regasini LO, Eduardo Miller Crotti A, Silvestri R, Guidi Magalhães L, Caffrey CR. PMID: 36608774; PMCID: PMC10072319.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling Using Leishmania donovani. Pathogens. 2022 Nov 26; 11(12). Hayat O, Ullah N, Sirajuddin M, Giardini MA, Nguyen JV, Francisco KR, Liu LJ, Sun YU, Maurya S, McGrosso D, Gonzalez DJ, Caffrey CR, Debnath A, Siqueira-Neto JL. PMID: 36558759; PMCID: PMC9785441.

View in: PubMed Mentions: 3 Fields:
Com Communicable Diseases Mic Microbiology
Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain. ACS Med Chem Lett. 2022 Nov 10; 13(11):1715-1722. Mathavan I, Liu LJ, Robinson SW, El-Sakkary N, Elatico AJJ, Gomez D, Nellas R, Owens RJ, Zuercher W, Navratilova I, Caffrey CR, Beis K. PMID: 36385939; PMCID: PMC9661718.

View in: PubMed Mentions: 3
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. Eur J Med Chem. 2021 Dec 15; 226:113823. Padalino G, El-Sakkary N, Liu LJ, Liu C, Harte DSG, Barnes RE, Sayers E, Forde-Thomas J, Whiteland H, Bassetto M, Ferla S, Johnson G, Jones AT, Caffrey CR, Chalmers I, Brancale A, Hoffmann KF. PMID: 34536671; PMCID: PMC8626775.

View in: PubMed Mentions: 8 Fields:
Che Chemistry
Translation:Humans Animals Cells
A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules. ACS Infect Dis. 2021 02 12; 7(2):406-420. Zorn KM, Sun S, McConnon CL, Ma K, Chen EK, Foil DH, Lane TR, Liu LJ, El-Sakkary N, Skinner DE, Ekins S, Caffrey CR. PMID: 33434015; PMCID: PMC7887754.

View in: PubMed Mentions: 11 Fields:
Ant Anti-Infective Agents Dru Drug Therapy Mic Microbiology
Translation:Animals
Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro. ACS Infect Dis. 2021 05 14; 7(5):1089-1103. Monti L, Cornec AS, Oukoloff K, Kovalevich J, Prijs K, Alle T, Brunden KR, Smith AB, El-Sakkary N, Liu LJ, Syed A, Skinner DE, Ballatore C, Caffrey CR. PMID: 33135408; PMCID: PMC8641298.

View in: PubMed Mentions: 9 Fields:
Ant Anti-Infective Agents Dru Drug Therapy Mic Microbiology
Translation:Humans Animals Cells