Alejandro Chavez

Photo of Alejandro Chavez
Title(s)Associate Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailalc042@ucsd.edu
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    Northwestern University, Evanston, ILBA06/2004Genetics and Molecular Biology
    University of Pennsylvania, Philadelphia, PAMD, PhD06/2011Cell and Molecular Biology
    Massachusetts General Hospital, Boston, MAResidency06/2014Clinical Pathology
    Wyss Institute at Harvard, Boston, MAClinical Fellow09/2017Genome Engineering and Synthetic Biology

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression. Cancer Res. 2026 Aug 14; 86(16):3920-3931. Powers J, Wei L, Cheung JCT, Ahmadi P, Kobayashi H, Curiel-Garcia A, Kang S, Valenzuela E, Jovanovic M, Chavez A, Chio IIC. PMID: 42202060; PMCID: PMC13276777.
      View in: PubMed   Mentions:    Fields:    
    2. HIT-MAP: A scalable approach to multimodal mapping of subcellular organization. Cell Rep Methods. 2026 Sep 21; 6(9):101534. Qian G, Kim J, Tiwari R, Polacco BJ, Forget A, Schaffer LV, Kim HK, Gao J, Zhou Y, Jang GM, Kelly MR, Zhao X, Foussard H, Zhang L, Krogan N, Ideker T, Chavez A. PMID: 42486102; PMCID: PMC13615500.
      View in: PubMed   Mentions:    Fields:    
    3. High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease. J Neuroinflammation. 2025 Dec 03; 22(1):294. Cardona CL, Wei L, Kim J, Angeles E, Singh G, Chen S, Patel R, Ifediora N, Canoll P, Teich AF, Hargus G, Chavez A, Sproul AA. PMID: 41340152; PMCID: PMC12729107.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity. Nat Commun. 2025 Nov 21; 16(1):10285. Resnick SJ, Qamar S, Krishna P, Korben VA, Ausserwoger H, Miller A, Esposito P, Varela JA, Sheng J, Huang LH, Nixon-Abell J, Melore S, Chung CW, Läubli NF, Kapsiani S, Li X, Wang J, Zhang N, Alam MM, Burguete AS, Swayne TC, Chen Y, Liao YC, Shneider NA, Vendruscolo M, Knowles TPJ, Kaminski CF, Ruggeri FS, Kaminski Schierle GS, St George-Hyslop P, Chavez A. PMID: 41271702; PMCID: PMC12638947.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    5. Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity. Nat Commun. 2025 Nov 20; 16(1):11114. Giddins M, Kratz AF, De Los Santos MB, Forget A, Tiwari R, Jang G, Blazejewski T, Qin C, Huang Y, Lao YH, Falconer T, Leong KW, Krogan N, Staller M, Wang H, Wei L, Chavez A. PMID: 41266370; PMCID: PMC12706070.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut. Nat Biotechnol. 2025 Nov 17. Huang Y, Sun Y, Ronda C, Mavros CF, Li J, Jacobse J, Huang LH, Resnick SJ, Giddins M, Freedberg DE, Chavez A, Goettel JA, Wang HH. PMID: 41249836; PMCID: PMC13035107.
      View in: PubMed   Mentions: 1     Fields:    
    7. CRISPR activation to repair electrocardiogram abnormalities caused by a FLNC truncating variant in mice. Eur Heart J. 2025 Nov 14; 46(43):4610-4613. Cañas-Alvaro R, Lalaguna L, Rubio B, Ausiello A, López-Olañeta M, Serrano-Blanco RF, Ochoa JP, de la Pompa JL, Chavez A, García-Pavía P, Lara-Pezzi E. PMID: 40886060; PMCID: PMC12614992.
      View in: PubMed   Mentions: 3     Fields:    
    8. A multiplex method for rapidly identifying viral protease inhibitors. Mol Syst Biol. 2025 Feb; 21(2):158-172. Hong SJ, Resnick SJ, Iketani S, Cha JW, Albert BA, Fazekas CT, Chang CW, Liu H, Dagan S, Abagyan MR, Fajtová P, Culbertson B, Brace B, Reddem ER, Forouhar F, Glickman JF, Balkovec JM, Stockwell BR, Shapiro L, O'Donoghue AJ, Sabo Y, Freundlich JS, Ho DD, Chavez A. PMID: 39762652; PMCID: PMC11790949.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. High-throughput tagging of endogenous loci for rapid characterization of protein function. Sci Adv. 2024 May 03; 10(18):eadg8771. Kim J, Kratz AF, Chen S, Sheng J, Kim HK, Zhang L, Singh BK, Chavez A. PMID: 38691600; PMCID: PMC11062585.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature. 2023 Oct; 622(7982):376-382. Duan Y, Zhou H, Liu X, Iketani S, Lin M, Zhang X, Bian Q, Wang H, Sun H, Hong SJ, Culbertson B, Mohri H, Luck MI, Zhu Y, Liu X, Lu Y, Yang X, Yang K, Sabo Y, Chavez A, Goff SP, Rao Z, Ho DD, Yang H. PMID: 37696289.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    11. Focused ultrasound-mediated brain genome editing. Proc Natl Acad Sci U S A. 2023 Aug 22; 120(34):e2302910120. Lao YH, Ji R, Zhou JK, Snow KJ, Kwon N, Saville E, He S, Chauhan S, Chi CW, Datta MS, Zhang H, Quek CH, Cai SS, Li M, Gaitan Y, Bechtel L, Wu SY, Lutz CM, Tomer R, Murray SA, Chavez A, Konofagou EE, Leong KW. PMID: 37579143; PMCID: PMC10450663.
      View in: PubMed   Mentions: 12     Fields:    
    12. Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases. Nat Biotechnol. 2024 Jan; 42(1):87-98. Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH. PMID: 36991112; PMCID: PMC10620015.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    13. Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans. G3 (Bethesda). 2023 Feb 09; 13(2). Gervais NC, La Bella AA, Wensing LF, Sharma J, Acquaviva V, Best M, Cadena López RO, Fogal M, Uthayakumar D, Chavez A, Santiago-Tirado F, Flores-Mireles AL, Shapiro RS. PMID: 36450451; PMCID: PMC9911074.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    14. Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir. Nature. 2023 Jan; 613(7944):558-564. Iketani S, Mohri H, Culbertson B, Hong SJ, Duan Y, Luck MI, Annavajhala MK, Guo Y, Sheng Z, Uhlemann AC, Goff SP, Sabo Y, Yang H, Chavez A, Ho DD. PMID: 36351451; PMCID: PMC9849135.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansCells
    15. Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites. Cell Host Microbe. 2022 Oct 12; 30(10):1354-1362.e6. Iketani S, Hong SJ, Sheng J, Bahari F, Culbertson B, Atanaki FF, Aditham AK, Kratz AF, Luck MI, Tian R, Goff SP, Montazeri H, Sabo Y, Ho DD, Chavez A. PMID: 36029764; PMCID: PMC9365866.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    16. An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Sci Transl Med. 2022 May 25; 14(646):eabn6859. Liu L, Iketani S, Guo Y, Reddem ER, Casner RG, Nair MS, Yu J, Chan JF, Wang M, Cerutti G, Li Z, Morano NC, Castagna CD, Corredor L, Chu H, Yuan S, Poon VK, Chan CC, Chen Z, Luo Y, Cunningham M, Chavez A, Yin MT, Perlin DS, Tsuji M, Yuen KY, Kwong PD, Sheng Z, Huang Y, Shapiro L, Ho DD. PMID: 35438546; PMCID: PMC9017343.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    17. Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun. 2022 Apr 07; 13(1):1891. Liu H, Iketani S, Zask A, Khanizeman N, Bednarova E, Forouhar F, Fowler B, Hong SJ, Mohri H, Nair MS, Huang Y, Tay NES, Lee S, Karan C, Resnick SJ, Quinn C, Li W, Shion H, Xia X, Daniels JD, Bartolo-Cruz M, Farina M, Rajbhandari P, Jurtschenko C, Lauber MA, McDonald T, Stokes ME, Hurst BL, Rovis T, Chavez A, Ho DD, Stockwell BR. PMID: 35393402; PMCID: PMC8989888.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCellsPHPublic Health
    18. Quantifying protein abundance on single cells using split-pool sequencing on DNA-barcoded antibodies for diagnostic applications. Sci Rep. 2022 Jan 18; 12(1):884. Sheng J, Hod EA, Vlad G, Chavez A. PMID: 35042926; PMCID: PMC8766443.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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