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    Conor Caffrey

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0755
    CA La Jolla 92093
    Phone858-534-5340
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      Collapse Research 
      Collapse Research Activities and Funding
      Defining the death transcriptome of Schistosoma mansoni to construct a molecular drug screen
      NIH/NIAID R21AI126296Feb 20, 2017 - Jan 31, 2019
      Role: Principal Investigator
      Exploring statins as a small molecule therapy for treatment of schistosomiasis
      NIH/NIAID R21AI107390Jun 5, 2013 - May 31, 2015
      Role: Principal Investigator
      An automated high throughput phenotypic screen for schistosomiasis drug discovery
      NIH/NIAID R01AI089896May 15, 2010 - Apr 30, 2014
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey C. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. PMID: 28704396.
        View in: PubMed
      2. Martin RJ, Wolstenholme AJ, Caffrey C. Anthelmintics: From discovery to resistance II (San Diego, 2016). Int J Parasitol Drugs Drug Resist. 2016 Dec; 6(3):297-298. PMID: 27814986.
        View in: PubMed
      3. Picard MA, Boissier J, Roquis D, Grunau C, Allienne JF, Duval D, Toulza E, Arancibia N, Caffrey C, Long T, Nidelet S, Rohmer M, Cosseau C. Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation. PLoS Negl Trop Dis. 2016 Sep; 10(9):e0004930. PMID: 27677173.
        View in: PubMed
      4. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey C, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 Jul; 12(7):e1005763. PMID: 27467575; PMCID: PMC4965013.
        View in: PubMed, PubMed Central
      5. Vermeire JJ, Suzuki BM, Caffrey C. Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo. Pharmaceuticals (Basel). 2016 Jul 04; 9(3). PMID: 27384569.
        View in: PubMed
      6. Singh R, Beasley R, Long T, Caffrey C. Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis. IEEE/ACM Trans Comput Biol Bioinform. 2016 Apr 07. PMID: 27071187.
        View in: PubMed
      7. Silveira AM, Costa EG, Ray D, Suzuki BM, Hsieh MH, Fraga LA, Caffrey C. Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004357. PMID: 26752073; PMCID: PMC4709075.
        View in: PubMed, PubMed Central
      8. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey C. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004356. PMID: 26751972; PMCID: PMC4709140.
        View in: PubMed, PubMed Central
      9. Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey C, O'Donoghue AJ. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. 2016 Mar; 122:99-109. PMID: 26409899; PMCID: PMC4747843 [Available on 03/01/17].
        View in: PubMed, PubMed Central
      10. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey C, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2015 Jun 25; 6:7485. PMID: 26108372; PMCID: PMC4491176.
        View in: PubMed, PubMed Central
      11. Glaser J, Schurigt U, Suzuki BM, Caffrey C, Holzgrabe U. Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni. Molecules. 2015 Jun 12; 20(6):10873-83. PMID: 26076109.
        View in: PubMed
      12. Fajtová P, Štefanic S, Hradilek M, Dvorák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey C, Mareš M, Horn M. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015; 9(6):e0003827. PMID: 26039195; PMCID: PMC4454677.
        View in: PubMed, PubMed Central
      13. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey C, de Oliveira RB, Ferreira RS. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. PMID: 25712353; PMCID: PMC4394791.
        View in: PubMed, PubMed Central
      14. Geary TG, Sakanari JA, Caffrey C. Anthelmintic drug discovery: into the future. J Parasitol. 2015 Apr; 101(2):125-33. PMID: 25584662.
        View in: PubMed
      15. Caffrey C. Schistosomiasis and its treatment. Future Med Chem. 2015; 7(6):675-6. PMID: 25996057.
        View in: PubMed
      16. Asarnow D, Rojo-Arreola L, Suzuki BM, Caffrey C, Singh R. The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens. Bioinformatics. 2015 May 01; 31(9):1515-8. PMID: 25540182; PMCID: PMC4410654.
        View in: PubMed, PubMed Central
      17. Jílková A, Horn M, Rezácová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey C, Mareš M. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure. 2014 Dec 02; 22(12):1786-98. PMID: 25456815.
        View in: PubMed
      18. Beckmann S, Long T, Scheld C, Geyer R, Caffrey C, Grevelding CG. Serum albumin and a-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib. Int J Parasitol Drugs Drug Resist. 2014 Dec; 4(3):287-95. PMID: 25516839; PMCID: PMC4266805.
        View in: PubMed, PubMed Central
      19. Andrade LF, Mourão Mde M, Geraldo JA, Coelho FS, Silva LL, Neves RH, Volpini A, Machado-Silva JR, Araujo N, Nacif-Pimenta R, Caffrey C, Oliveira G. Regulation of Schistosoma mansoni development and reproduction by the mitogen-activated protein kinase signaling pathway. PLoS Negl Trop Dis. 2014 Jun; 8(6):e2949. PMID: 24945272; PMCID: PMC4063740.
        View in: PubMed, PubMed Central
      20. Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey C, Dvorák J. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2766. PMID: 24676141; PMCID: PMC3967958.
        View in: PubMed, PubMed Central
      21. Rojo-Arreola L, Long T, Asarnow D, Suzuki BM, Singh R, Caffrey C. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One. 2014; 9(1):e87594. PMID: 24489942; PMCID: PMC3906178.
        View in: PubMed, PubMed Central
      22. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey C. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec; 57(12):6063-73. PMID: 24060869; PMCID: PMC3837922.
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      23. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey C, Tort JF. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. PMID: 23875031; PMCID: PMC3708847.
        View in: PubMed, PubMed Central
      24. Sojka D, Franta Z, Horn M, Caffrey C, Mareš M, Kopácek P. New insights into the machinery of blood digestion by ticks. Trends Parasitol. 2013 Jun; 29(6):276-85. PMID: 23664173.
        View in: PubMed
      25. Mashiyama ST, Koupparis K, Caffrey C, McKerrow JH, Babbitt PC. A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. PLoS Negl Trop Dis. 2012; 6(12):e1942. PMID: 23236535; PMCID: PMC3516576.
        View in: PubMed, PubMed Central
      26. Vermeire JJ, Lantz LD, Caffrey C. Cure of hookworm infection with a cysteine protease inhibitor. PLoS Negl Trop Dis. 2012; 6(7):e1680. PMID: 22802972; PMCID: PMC3389033.
        View in: PubMed, PubMed Central
      27. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey C, McKerrow JH, Mares M, Kopácek P. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. PMID: 22539347; PMCID: PMC3375538.
        View in: PubMed, PubMed Central
      28. Steverding D, Sexton DW, Wang X, Gehrke SS, Wagner GK, Caffrey C. Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. Int J Parasitol. 2012 May 01; 42(5):481-8. PMID: 22549023.
        View in: PubMed
      29. Lee H, Moody-Davis A, Saha U, Suzuki BM, Asarnow D, Chen S, Arkin M, Caffrey C, Singh R. Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics. 2012; 13 Suppl 1:S4. PMID: 22369037; PMCID: PMC3471343.
        View in: PubMed, PubMed Central
      30. Abdulla MH, Lim KC, McKerrow JH, Caffrey C. Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1368. PMID: 22039561; PMCID: PMC3201919.
        View in: PubMed, PubMed Central
      31. Swain MT, Larkin DM, Caffrey C, Davies SJ, Loukas A, Skelly PJ, Hoffmann KF. Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery. Trends Parasitol. 2011 Dec; 27(12):555-64. PMID: 22024648; PMCID: PMC3223292.
        View in: PubMed, PubMed Central
      32. Caffrey C, Secor WE. Schistosomiasis: from drug deployment to drug development. Curr Opin Infect Dis. 2011 Oct; 24(5):410-7. PMID: 21734570.
        View in: PubMed
      33. Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey C, Mares M. Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. J Biol Chem. 2011 Oct 14; 286(41):35770-81. PMID: 21832058; PMCID: PMC3195637.
        View in: PubMed, PubMed Central
      34. Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey C, Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol. 2011 Oct; 41(12):1253-62. PMID: 21819989.
        View in: PubMed
      35. Horn M, Jílková A, Vondrásek J, Maresová L, Caffrey C, Mares M. Mapping the pro-peptide of the Schistosoma mansoni cathepsin B1 drug target: modulation of inhibition by heparin and design of mimetic inhibitors. ACS Chem Biol. 2011 Jun 17; 6(6):609-17. PMID: 21375333.
        View in: PubMed
      36. Caffrey C, Lima AP, Steverding D. Cysteine peptidases of kinetoplastid parasites. Adv Exp Med Biol. 2011; 712:84-99. PMID: 21660660.
        View in: PubMed
      37. de Oliveira Fraga LA, Lamb EW, Moreno EC, Chatterjee M, Dvorák J, Delcroix M, Sajid M, Caffrey C, Davies SJ. Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection. BMC Immunol. 2010 Nov 15; 11:56. PMID: 21078176; PMCID: PMC2993659.
        View in: PubMed, PubMed Central
      38. Stefanic S, Dvorák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey C. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis. 2010 Oct 19; 4(10):e850. PMID: 20976050; PMCID: PMC2957409.
        View in: PubMed, PubMed Central
      39. Utzinger J, N'goran EK, Caffrey C, Keiser J. From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop. 2011 Sep; 120 Suppl 1:S121-37. PMID: 20831855.
        View in: PubMed
      40. Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey C, Daffre S. Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasit Vectors. 2010 Jul 27; 3:63. PMID: 20663211; PMCID: PMC2921360.
        View in: PubMed, PubMed Central
      41. Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey C, Powers JC. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem. 2009 Nov 26; 52(22):7192-210. PMID: 19848405.
        View in: PubMed
      42. Dvorák J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey C. Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Mol Biochem Parasitol. 2010 Mar; 170(1):37-40. PMID: 19914302.
        View in: PubMed
      43. Horn M, Nussbaumerová M, Sanda M, Kovárová Z, Srba J, Franta Z, Sojka D, Bogyo M, Caffrey C, Kopácek P, Mares M. Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol. 2009 Oct 30; 16(10):1053-63. PMID: 19875079; PMCID: PMC2801564.
        View in: PubMed, PubMed Central
      44. Mallari JP, Shelat AA, Kosinski A, Caffrey C, Connelly M, Zhu F, McKerrow JH, Guy RK. Structure-guided development of selective TbcatB inhibitors. J Med Chem. 2009 Oct 22; 52(20):6489-93. PMID: 19769357; PMCID: PMC2762491.
        View in: PubMed, PubMed Central
      45. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey C, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. PMID: 19620707; PMCID: PMC2757971.
        View in: PubMed, PubMed Central
      46. Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey C, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16; 460(7253):352-8. PMID: 19606141; PMCID: PMC2756445.
        View in: PubMed, PubMed Central
      47. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey C. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis. 2009 Jul 14; 3(7):e478. PMID: 19597541; PMCID: PMC2702839.
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      48. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey C. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009 Jun 02; 3(6):e449. PMID: 19488406; PMCID: PMC2685030.
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      49. Caffrey C, Steverding D. Kinetoplastid papain-like cysteine peptidases. Mol Biochem Parasitol. 2009 Sep; 167(1):12-9. PMID: 19409421.
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      50. Caffrey C, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM. A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One. 2009; 4(2):e4413. PMID: 19198654; PMCID: PMC2635471.
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      51. Kasný M, Mikes L, Hampl V, Dvorák J, Caffrey C, Dalton JP, Horák P. Chapter 4. Peptidases of trematodes. Adv Parasitol. 2009; 69:205-97. PMID: 19622410.
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      52. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey C, McKerrow JH. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. PMID: 18701454; PMCID: PMC2570886.
        View in: PubMed, PubMed Central
      53. Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey C, Powers JC. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 08; 51(9):2816-32. PMID: 18416543.
        View in: PubMed
      54. Mallari JP, Shelat A, Kosinski A, Caffrey C, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 01; 18(9):2883-5. PMID: 18420405; PMCID: PMC2435229.
        View in: PubMed, PubMed Central
      55. Sojka D, Franta Z, Horn M, Hajdusek O, Caffrey C, Mares M, Kopácek P. Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasit Vectors. 2008 Mar 18; 1(1):7. PMID: 18348719; PMCID: PMC2289814.
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      56. Caffrey C, Steverding D. Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Expert Opin Drug Discov. 2008 Feb; 3(2):173-86. PMID: 23480221.
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      57. Mallari JP, Shelat AA, Obrien T, Caffrey C, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14; 51(3):545-52. PMID: 18173229.
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      58. Stack CM, Caffrey C, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem. 2008 Apr 11; 283(15):9896-908. PMID: 18160404; PMCID: PMC3979170.
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      59. Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey C, McKerrow JH. Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2008 Feb; 90(2):345-58. PMID: 17936488.
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      60. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Lett. 2007 Sep 04; 581(22):4260-4. PMID: 17707374.
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      61. Caffrey C. Chemotherapy of schistosomiasis: present and future. Curr Opin Chem Biol. 2007 Aug; 11(4):433-9. PMID: 17652008.
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      62. Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey C, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell. 2007 Jul; 6(7):1130-6. PMID: 17513563; PMCID: PMC1951106.
        View in: PubMed, PubMed Central
      63. Delcroix M, Medzihradsky K, Caffrey C, Fetter RD, McKerrow JH. Proteomic analysis of adult S. mansoni gut contents. Mol Biochem Parasitol. 2007 Jul; 154(1):95-7. PMID: 17451823; PMCID: PMC2732360.
        View in: PubMed, PubMed Central
      64. Caffrey C, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72. PMID: 17371810; PMCID: PMC1891397.
        View in: PubMed, PubMed Central
      65. Scory S, Stierhof YD, Caffrey C, Steverding D. The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo. Kinetoplastid Biol Dis. 2007 Feb 28; 6:2. PMID: 17328798; PMCID: PMC1810305.
        View in: PubMed, PubMed Central
      66. Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey C, Kopácek P. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol. 2007 Jun; 37(7):713-24. PMID: 17336985; PMCID: PMC2587490.
        View in: PubMed, PubMed Central
      67. Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey C. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med. 2007 Jan; 4(1):e14. PMID: 17214506; PMCID: PMC1764436.
        View in: PubMed, PubMed Central
      68. Delcroix M, Sajid M, Caffrey C, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH. A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. J Biol Chem. 2006 Dec 22; 281(51):39316-29. PMID: 17028179.
        View in: PubMed
      69. Steverding D, Caffrey C, Sajid M. Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design. Mini Rev Med Chem. 2006 Sep; 6(9):1025-32. PMID: 17018001.
        View in: PubMed
      70. Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey C, McKerrow JH, Pike RN, Spithill TW. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol Chem. 2006 Aug; 387(8):1053-61. PMID: 16895475.
        View in: PubMed
      71. Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey C, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett. 2006 May 15; 16(10):2753-7. PMID: 16516467.
        View in: PubMed
      72. McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M. Proteases in parasitic diseases. Annu Rev Pathol. 2006; 1:497-536. PMID: 18039124.
        View in: PubMed
      73. Huete-Pérez JA, Flores-Obando RE, Ghedin E, Caffrey C. Genomic and proteomic approaches for Chagas' disease: critical analysis of diagnostic methods. Expert Rev Mol Diagn. 2005 Jul; 5(4):521-30. PMID: 16013970.
        View in: PubMed
      74. Dvorák J, Delcroix M, Rossi A, Vopálenský V, Pospísek M, Sedinová M, Mikes L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey C. Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition. Int J Parasitol. 2005 Jul; 35(8):895-910. PMID: 15950230.
        View in: PubMed
      75. Caffrey C, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondrásek J. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors. Biol Chem. 2005 Apr; 386(4):339-49. PMID: 15899696.
        View in: PubMed
      76. Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey C. Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. Int J Parasitol. 2005 May; 35(6):583-9. PMID: 15862572.
        View in: PubMed
      77. Götz MG, Caffrey C, Hansell E, McKerrow JH, Powers JC. Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. Bioorg Med Chem. 2004 Oct 01; 12(19):5203-11. PMID: 15351403.
        View in: PubMed
      78. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey C, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. PMID: 15163200.
        View in: PubMed
      79. Caffrey C, McKerrow JH, Salter JP, Sajid M. Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 2004 May; 20(5):241-8. PMID: 15105025.
        View in: PubMed
      80. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey C, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 08; 47(8):1889-92. PMID: 15055989.
        View in: PubMed
      81. James KE, Götz MG, Caffrey C, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec; 384(12):1613-8. PMID: 14719804.
        View in: PubMed
      82. Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey C. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003 Sep; 131(1):65-75. PMID: 12967713.
        View in: PubMed
      83. Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey C, Steverding D. Improved trypanocidal activities of cathepsin L inhibitors. Int J Antimicrob Agents. 2003 Aug; 22(2):155-9. PMID: 12927956.
        View in: PubMed
      84. Du X, Guo C, Hansell E, Doyle PS, Caffrey C, Holler TP, McKerrow JH, Cohen FE. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20; 45(13):2695-707. PMID: 12061873.
        View in: PubMed
      85. Caffrey C, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30; 121(1):49-61. PMID: 11985862.
        View in: PubMed
      86. Mathieu MA, Bogyo M, Caffrey C, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. PMID: 11985866.
        View in: PubMed
      87. Caffrey C, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31. PMID: 11932146.
        View in: PubMed
      88. Caffrey C, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol. 2001 Nov; 118(1):61-73. PMID: 11704274.
        View in: PubMed
      89. Caffrey C, Scory S, Steverding D. Cysteine proteinases of trypanosome parasites: novel targets for chemotherapy. Curr Drug Targets. 2000 Sep; 1(2):155-62. PMID: 11465068.
        View in: PubMed
      90. Du X, Hansell E, Engel JC, Caffrey C, Cohen FE, McKerrow JH. Aryl ureas represent a new class of anti-trypanosomal agents. Chem Biol. 2000 Sep; 7(9):733-42. PMID: 10980453.
        View in: PubMed
      91. Caffrey C, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Lett. 2000 Jan 28; 466(2-3):244-8. PMID: 10682836.
        View in: PubMed
      92. Caffrey C, Gsell C, Ruppel A. Schistosoma japonicum is less sensitive to cyclosporin A in vivo than Schistosoma mansoni. J Parasitol. 1999 Aug; 85(4):736-9. PMID: 10461959.
        View in: PubMed
      93. McKerrow JH, Engel JC, Caffrey C. Cysteine protease inhibitors as chemotherapy for parasitic infections. Bioorg Med Chem. 1999 Apr; 7(4):639-44. PMID: 10353643.
        View in: PubMed
      94. Scory S, Caffrey C, Stierhof YD, Ruppel A, Steverding D. Trypanosoma brucei: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-phe-ala-CHN2. Exp Parasitol. 1999 Apr; 91(4):327-33. PMID: 10092476.
        View in: PubMed
      95. Rheinberg CE, Moné H, Caffrey C, Imbert-Establet D, Jourdane J, Ruppel A. Schistosoma haematobium, S. intercalatum, S. japonicum, S. mansoni, and S. rodhaini in mice: relationship between patterns of lung migration by schistosomula and perfusion recovery of adult worms. Parasitol Res. 1998; 84(4):338-42. PMID: 9569102.
        View in: PubMed
      96. Li Y, Fen Y, Caffrey C, Ruppel A. [Studies on cathepsins in Schistosoma japonicum]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1998; 16(2):101-4. PMID: 12078215.
        View in: PubMed
      97. Caffrey C, Ruppel A. Affinity isolation and characterization of the cathepsin B-like proteinase Sj31 from Schistosoma japonicum. J Parasitol. 1997 Dec; 83(6):1112-8. PMID: 9406788.
        View in: PubMed
      98. Caffrey C, Ruppel A. Cathepsin B-like activity predominates over cathepsin L-like activity in adult Schistosoma mansoni and S. japonicum. Parasitol Res. 1997; 83(6):632-5. PMID: 9211519.
        View in: PubMed
      99. Caffrey C, Rheinberg CE, Moné H, Jourdane J, Li YL, Ruppel A. Schistosoma japonicum, S. mansoni, S. haematobium, S. intercalatum, and S. rodhaini: cysteine-class cathepsin activities in the vomitus of adult worms. Parasitol Res. 1997; 83(1):37-41. PMID: 9000231.
        View in: PubMed
      100. Caffrey C, Ryan MF. Characterisation of proteolytic activity of excretory-secretory products from adult Strongylus vulgaris. Vet Parasitol. 1994 Apr; 52(3-4):285-96. PMID: 8073612.
        View in: PubMed
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