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Conor Caffrey

TitleAssociate Professor In Residence
InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0755
La Jolla CA 92093
Phone858-534-5340
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    Collapse Research 
    Collapse Research Activities and Funding
    Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseases
    NIH/NIAID R21AI133394Jun 1, 2018 - May 31, 2020
    Role: Principal Investigator
    Defining the death transcriptome of Schistosoma mansoni to construct a molecular drug screen
    NIH/NIAID R21AI126296Feb 20, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Exploring statins as a small molecule therapy for treatment of schistosomiasis
    NIH/NIAID R21AI107390Jun 5, 2013 - May 31, 2015
    Role: Principal Investigator
    An automated high throughput phenotypic screen for schistosomiasis drug discovery
    NIH/NIAID R01AI089896May 15, 2010 - Apr 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Monti L, Wang SC, Oukoloff K, Smith AB, Brunden KR, Caffrey C, Ballatore C. Brain-penetrant, triazolopyrimidine and phenylpyrimidine microtubule-stabilizers as potential leads to treat human African trypanosomiasis. ChemMedChem. 2018 Jul 03. PMID: 29969537.
      View in: PubMed
    2. El-Sakkary N, Chen S, Arkin MR, Caffrey C, Ribeiro P. Octopamine-signaling in the metazoan pathogen, Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development. Dis Model Mech. 2018 Jun 20. PMID: 29925529.
      View in: PubMed
    3. Kyere-Davies G, Agyare C, Boakye YD, Suzuki BM, Caffrey C. Effect of Phenotypic Screening of Extracts and Fractions of Erythrophleum ivorense Leaf and Stem Bark on Immature and Adult Stages of Schistosoma mansoni. J Parasitol Res. 2018; 2018:9431467. PMID: 29977614.
      View in: PubMed
    4. Leontovyc A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey C, Mareš M, Dvorák J, Horn M. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. PLoS Negl Trop Dis. 2018 Apr; 12(4):e0006446. PMID: 29677188.
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    5. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey C, Tort JF. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. PMID: 29725596.
      View in: PubMed
    6. Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey C, Liachko NF. Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing. Sci Rep. 2018 Jan 17; 8(1):975. PMID: 29343694.
      View in: PubMed
    7. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey C. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. PMID: 28704396.
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    8. Bibo-Verdugo B, Jiang Z, Caffrey C, O'Donoghue AJ. Targeting proteasomes in infectious organisms to combat disease. FEBS J. 2017 05; 284(10):1503-1517. PMID: 28122162.
      View in: PubMed
    9. Martin RJ, Wolstenholme AJ, Caffrey C. Anthelmintics: From discovery to resistance II (San Diego, 2016). Int J Parasitol Drugs Drug Resist. 2016 12; 6(3):297-298. PMID: 27814986.
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    10. Picard MA, Boissier J, Roquis D, Grunau C, Allienne JF, Duval D, Toulza E, Arancibia N, Caffrey C, Long T, Nidelet S, Rohmer M, Cosseau C. Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation. PLoS Negl Trop Dis. 2016 Sep; 10(9):e0004930. PMID: 27677173.
      View in: PubMed
    11. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey C, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 Jul; 12(7):e1005763. PMID: 27467575.
      View in: PubMed
    12. Vermeire JJ, Suzuki BM, Caffrey C. Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo. Pharmaceuticals (Basel). 2016 Jul 04; 9(3). PMID: 27384569.
      View in: PubMed
    13. Singh R, Beasley R, Long T, Caffrey C. Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis. IEEE/ACM Trans Comput Biol Bioinform. 2018 Mar-Apr; 15(2):469-481. PMID: 27071187.
      View in: PubMed
    14. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey C. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004356. PMID: 26751972; PMCID: PMC4709140.
      View in: PubMed, PubMed Central
    15. Silveira AM, Costa EG, Ray D, Suzuki BM, Hsieh MH, Fraga LA, Caffrey C. Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004357. PMID: 26752073.
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    16. Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey C, O'Donoghue AJ. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. 2016 Mar; 122:99-109. PMID: 26409899; PMCID: PMC4747843 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    17. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey C, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2015 Jun 25; 6:7485. PMID: 26108372; PMCID: PMC4491176.
      View in: PubMed, PubMed Central
    18. Glaser J, Schurigt U, Suzuki BM, Caffrey C, Holzgrabe U. Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni. Molecules. 2015 Jun 12; 20(6):10873-83. PMID: 26076109.
      View in: PubMed
    19. Fajtová P, Štefanic S, Hradilek M, Dvorák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey C, Mareš M, Horn M. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015; 9(6):e0003827. PMID: 26039195; PMCID: PMC4454677.
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    20. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey C, de Oliveira RB, Ferreira RS. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. PMID: 25712353; PMCID: PMC4394791.
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    21. Geary TG, Sakanari JA, Caffrey C. Anthelmintic drug discovery: into the future. J Parasitol. 2015 Apr; 101(2):125-33. PMID: 25584662.
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    22. Caffrey C. Schistosomiasis and its treatment. Future Med Chem. 2015; 7(6):675-6. PMID: 25996057.
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    23. Asarnow D, Rojo-Arreola L, Suzuki BM, Caffrey C, Singh R. The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens. Bioinformatics. 2015 May 01; 31(9):1515-8. PMID: 25540182; PMCID: PMC4410654.
      View in: PubMed, PubMed Central
    24. Jílková A, Horn M, Rezácová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey C, Mareš M. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure. 2014 Dec 02; 22(12):1786-1798. PMID: 25456815.
      View in: PubMed
    25. Beckmann S, Long T, Scheld C, Geyer R, Caffrey C, Grevelding CG. Serum albumin and a-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib. Int J Parasitol Drugs Drug Resist. 2014 Dec; 4(3):287-95. PMID: 25516839; PMCID: PMC4266805.
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    26. Andrade LF, Mourão Mde M, Geraldo JA, Coelho FS, Silva LL, Neves RH, Volpini A, Machado-Silva JR, Araujo N, Nacif-Pimenta R, Caffrey C, Oliveira G. Regulation of Schistosoma mansoni development and reproduction by the mitogen-activated protein kinase signaling pathway. PLoS Negl Trop Dis. 2014 Jun; 8(6):e2949. PMID: 24945272; PMCID: PMC4063740.
      View in: PubMed, PubMed Central
    27. Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey C, Dvorák J. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2766. PMID: 24676141; PMCID: PMC3967958.
      View in: PubMed, PubMed Central
    28. Rojo-Arreola L, Long T, Asarnow D, Suzuki BM, Singh R, Caffrey C. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One. 2014; 9(1):e87594. PMID: 24489942; PMCID: PMC3906178.
      View in: PubMed, PubMed Central
    29. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey C. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec; 57(12):6063-73. PMID: 24060869; PMCID: PMC3837922.
      View in: PubMed, PubMed Central
    30. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey C, Tort JF. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. PMID: 23875031; PMCID: PMC3708847.
      View in: PubMed, PubMed Central
    31. Sojka D, Franta Z, Horn M, Caffrey C, Mareš M, Kopácek P. New insights into the machinery of blood digestion by ticks. Trends Parasitol. 2013 Jun; 29(6):276-85. PMID: 23664173.
      View in: PubMed
    32. Mashiyama ST, Koupparis K, Caffrey C, McKerrow JH, Babbitt PC. A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. PLoS Negl Trop Dis. 2012; 6(12):e1942. PMID: 23236535; PMCID: PMC3516576.
      View in: PubMed, PubMed Central
    33. Vermeire JJ, Lantz LD, Caffrey C. Cure of hookworm infection with a cysteine protease inhibitor. PLoS Negl Trop Dis. 2012; 6(7):e1680. PMID: 22802972; PMCID: PMC3389033.
      View in: PubMed, PubMed Central
    34. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey C, McKerrow JH, Mares M, Kopácek P. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. PMID: 22539347; PMCID: PMC3375538.
      View in: PubMed, PubMed Central
    35. Steverding D, Sexton DW, Wang X, Gehrke SS, Wagner GK, Caffrey C. Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. Int J Parasitol. 2012 May 01; 42(5):481-8. PMID: 22549023.
      View in: PubMed
    36. Lee H, Moody-Davis A, Saha U, Suzuki BM, Asarnow D, Chen S, Arkin M, Caffrey C, Singh R. Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics. 2012; 13 Suppl 1:S4. PMID: 22369037; PMCID: PMC3471343.
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    37. Abdulla MH, Lim KC, McKerrow JH, Caffrey C. Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1368. PMID: 22039561; PMCID: PMC3201919.
      View in: PubMed, PubMed Central
    38. Swain MT, Larkin DM, Caffrey C, Davies SJ, Loukas A, Skelly PJ, Hoffmann KF. Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery. Trends Parasitol. 2011 Dec; 27(12):555-64. PMID: 22024648; PMCID: PMC3223292.
      View in: PubMed, PubMed Central
    39. Caffrey C, Secor WE. Schistosomiasis: from drug deployment to drug development. Curr Opin Infect Dis. 2011 Oct; 24(5):410-7. PMID: 21734570.
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    40. Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey C, Mares M. Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. J Biol Chem. 2011 Oct 14; 286(41):35770-81. PMID: 21832058; PMCID: PMC3195637.
      View in: PubMed, PubMed Central
    41. Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey C, Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol. 2011 Oct; 41(12):1253-62. PMID: 21819989.
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    42. Horn M, Jílková A, Vondrásek J, Maresová L, Caffrey C, Mares M. Mapping the pro-peptide of the Schistosoma mansoni cathepsin B1 drug target: modulation of inhibition by heparin and design of mimetic inhibitors. ACS Chem Biol. 2011 Jun 17; 6(6):609-17. PMID: 21375333.
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    43. Caffrey C, Lima AP, Steverding D. Cysteine peptidases of kinetoplastid parasites. Adv Exp Med Biol. 2011; 712:84-99. PMID: 21660660.
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    44. de Oliveira Fraga LA, Lamb EW, Moreno EC, Chatterjee M, Dvorák J, Delcroix M, Sajid M, Caffrey C, Davies SJ. Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection. BMC Immunol. 2010 Nov 15; 11:56. PMID: 21078176; PMCID: PMC2993659.
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    45. Stefanic S, Dvorák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey C. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis. 2010 Oct 19; 4(10):e850. PMID: 20976050; PMCID: PMC2957409.
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    46. Utzinger J, N'goran EK, Caffrey C, Keiser J. From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop. 2011 Sep; 120 Suppl 1:S121-37. PMID: 20831855.
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    47. Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey C, Daffre S. Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasit Vectors. 2010 Jul 27; 3:63. PMID: 20663211; PMCID: PMC2921360.
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    48. Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey C, Powers JC. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem. 2009 Nov 26; 52(22):7192-210. PMID: 19848405.
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    49. Dvorák J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey C. Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Mol Biochem Parasitol. 2010 Mar; 170(1):37-40. PMID: 19914302.
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    50. Horn M, Nussbaumerová M, Sanda M, Kovárová Z, Srba J, Franta Z, Sojka D, Bogyo M, Caffrey C, Kopácek P, Mares M. Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol. 2009 Oct 30; 16(10):1053-63. PMID: 19875079; PMCID: PMC2801564.
      View in: PubMed, PubMed Central
    51. Mallari JP, Shelat AA, Kosinski A, Caffrey C, Connelly M, Zhu F, McKerrow JH, Guy RK. Structure-guided development of selective TbcatB inhibitors. J Med Chem. 2009 Oct 22; 52(20):6489-93. PMID: 19769357; PMCID: PMC2762491.
      View in: PubMed, PubMed Central
    52. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey C, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. PMID: 19620707; PMCID: PMC2757971.
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    53. Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey C, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16; 460(7253):352-8. PMID: 19606141.
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    54. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey C. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis. 2009 Jul 14; 3(7):e478. PMID: 19597541; PMCID: PMC2702839.
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    55. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey C. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009 Jun 02; 3(6):e449. PMID: 19488406; PMCID: PMC2685030.
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    56. Caffrey C, Steverding D. Kinetoplastid papain-like cysteine peptidases. Mol Biochem Parasitol. 2009 Sep; 167(1):12-9. PMID: 19409421.
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    57. Caffrey C, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM. A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One. 2009; 4(2):e4413. PMID: 19198654; PMCID: PMC2635471.
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    58. Kasný M, Mikes L, Hampl V, Dvorák J, Caffrey C, Dalton JP, Horák P. Chapter 4. Peptidases of trematodes. Adv Parasitol. 2009; 69:205-97. PMID: 19622410.
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    59. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey C, McKerrow JH. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. PMID: 18701454; PMCID: PMC2570886.
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    60. Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey C, Powers JC. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 08; 51(9):2816-32. PMID: 18416543.
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    61. Mallari JP, Shelat A, Kosinski A, Caffrey C, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 01; 18(9):2883-5. PMID: 18420405; PMCID: PMC2435229.
      View in: PubMed, PubMed Central
    62. Sojka D, Franta Z, Horn M, Hajdusek O, Caffrey C, Mares M, Kopácek P. Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasit Vectors. 2008 Mar 18; 1(1):7. PMID: 18348719; PMCID: PMC2289814.
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    70. Delcroix M, Medzihradsky K, Caffrey C, Fetter RD, McKerrow JH. Proteomic analysis of adult S. mansoni gut contents. Mol Biochem Parasitol. 2007 Jul; 154(1):95-7. PMID: 17451823; PMCID: PMC2732360.
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    88. James KE, Götz MG, Caffrey C, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec; 384(12):1613-8. PMID: 14719804.
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    91. Du X, Guo C, Hansell E, Doyle PS, Caffrey C, Holler TP, McKerrow JH, Cohen FE. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20; 45(13):2695-707. PMID: 12061873.
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    92. Caffrey C, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30; 121(1):49-61. PMID: 11985862.
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    94. Caffrey C, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31. PMID: 11932146.
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