Loading...

Conor Caffrey

Title(s)Professor In Residence, School of Pharmacy and Pharmaceutical Science
SchoolHealth Sciences
Address9500 Gilman Drive #0755
La Jolla CA 92093
Phone858-534-5340
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Translational development of cysteine protease inhibitors to treat hookworm disease
    NIH/NIAID R21AI142452Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Reasoning with chemically induced dynamic phenotypes in whole-organism assays
    NIH/NIAID R21AI146719Jun 1, 2019 - May 31, 2021
    Role: Co-Principal Investigator
    Brain Penetrant Microtubule-Stabilizers to Treat CNS-invasive Parasitic Diseases
    NIH/NIAID R21AI141210Feb 1, 2019 - Jan 31, 2021
    Role: Co-Principal Investigator
    Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseases
    NIH/NIAID R21AI133394Jun 1, 2018 - May 31, 2020
    Role: Principal Investigator
    Defining the death transcriptome of Schistosoma mansoni to construct a molecular drug screen
    NIH/NIAID R21AI126296Feb 20, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Exploring statins as a small molecule therapy for treatment of schistosomiasis
    NIH/NIAID R21AI107390Jun 5, 2013 - May 31, 2015
    Role: Principal Investigator
    An automated high throughput phenotypic screen for schistosomiasis drug discovery
    NIH/NIAID R01AI089896May 15, 2010 - Apr 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors. J Enzyme Inhib Med Chem. 2020 Dec; 35(1):1387-1402. Corrigan TS, Lotti Diaz LM, Border SE, Ratigan SC, Kasper KQ, Sojka D, Fajtova P, Caffrey CR, Salvesen GS, McElroy CA, Hadad CM, Dogan Ekici Ö. PMID: 32633155.
      View in: PubMed   Mentions:    Fields:    
    2. Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2020 Jul 24; 11(1):3779. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, McQuibban GA, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. PMID: 32709866.
      View in: PubMed   Mentions:    Fields:    
    3. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone. J Antimicrob Chemother. 2020 Jul 02. Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta AP, Skinner DE, El-Sakkary N, Momper JD, Gangoiti J, Dong Y, Vennerstrom JL, Charman SA, Caffrey CR, Keiser J. PMID: 32617557.
      View in: PubMed   Mentions:    Fields:    
    4. Uncovering biological application of Brazilian green propolis: a phenotypic screening against Schistosoma mansoni. Chem Biodivers. 2020 Jun 23. de L Paula LA, Santos MF, Pagotti MC, Faleiros R, Ramos HP, Veneziani RC, Bastos JK, Caffrey CR, Ambrósio SR, Guidi Magalhães L. PMID: 32578329.
      View in: PubMed   Mentions:    Fields:    
    5. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Negl Trop Dis. 2020 03; 14(3):e0008150. Ehrenkaufer G, Li P, Stebbins EE, Kangussu-Marcolino MM, Debnath A, White CV, Moser MS, DeRisi J, Gisselberg J, Yeh E, Wang SC, Company AH, Monti L, Caffrey CR, Huston CD, Wang B, Singh U. PMID: 32196500.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin. Front Cell Infect Microbiol. 2020; 10:66. Dvoráková H, Leontovyc R, Machácek T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L. PMID: 32175287.
      View in: PubMed   Mentions:    Fields:    
    7. Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity. Sci Rep. 2020 Feb 13; 10(1):2587. Ferraro F, Corvo I, Bergalli L, Ilarraz A, Cabrera M, Gil J, Susuki BM, Caffrey CR, Timson DJ, Robert X, Guillon C, Freire T, Álvarez G. PMID: 32054976.
      View in: PubMed   Mentions:    Fields:    
    8. Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty. Pharmaceuticals (Basel). 2020 02 03; 13(2). Singh S, El-Sakkary N, Skinner DE, Sharma PP, Ottilie S, Antonova-Koch Y, Kumar P, Winzeler E, Caffrey CR, Rathi B. PMID: 32028743.
      View in: PubMed   Mentions:
    9. Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni. ACS Med Chem Lett. 2020 Mar 12; 11(3):258-265. Buskes MJ, Clements M, Bachovchin KA, Jalani HB, Leonard A, Bag S, Klug DM, Singh B, Campbell RF, Sciotti RJ, El-Sakkary N, Caffrey CR, Pollastri MP, Ferrins L. PMID: 32184954.
      View in: PubMed   Mentions:
    10. Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis. J Med Chem. 2020 Jan 23; 63(2):756-783. Tear WF, Bag S, Diaz-Gonzalez R, Ceballos-Pérez G, Rojas-Barros DI, Cordon-Obras C, Pérez-Moreno G, García-Hernández R, Martinez-Martinez MS, Ruiz-Perez LM, Gamarro F, Gonzalez Pacanowska D, Caffrey CR, Ferrins L, Manzano P, Navarro M, Pollastri MP. PMID: 31846577.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics. J Med Chem. 2020 Mar 12; 63(5):2527-2546. Klug DM, Tschiegg L, Diaz R, Rojas-Barros D, Perez-Moreno G, Ceballos G, García-Hernández R, Martinez-Martinez MS, Manzano P, Ruiz LM, Caffrey CR, Gamarro F, Pacanowska DG, Ferrins L, Navarro M, Pollastri MP. PMID: 31670951.
      View in: PubMed   Mentions: 1     Fields:    
    12. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 11; 63(11). O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. PMID: 31451503.
      View in: PubMed   Mentions: 2     Fields:    
    13. Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery. Parasit Vectors. 2019 Oct 22; 12(1):493. Maccesi M, Aguiar PHN, Pasche V, Padilla M, Suzuki BM, Montefusco S, Abagyan R, Keiser J, Mourão MM, Caffrey CR. PMID: 31640761.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    14. The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni. ACS Infect Dis. 2019 10 11; 5(10):1802-1812. Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. PMID: 31355632.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain). Parasit Vectors. 2019 Jul 30; 12(1):383. Chaimon S, Limpanont Y, Reamtong O, Ampawong S, Phuphisut O, Chusongsang P, Ruangsittichai J, Boonyuen U, Watthanakulpanich D, O'Donoghue AJ, Caffrey CR, Adisakwattana P. PMID: 31362766.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    16. Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei. Future Med Chem. 2019 07; 11(13):1537-1551. Pereira GA, Santos LH, Wang SC, Martins LC, Villela FS, Liao W, Dessoy MA, Dias LC, Andricopulo AD, Costa MA, Nagem RA, Caffrey CR, Liedl KR, Caffarena ER, Ferreira RS. PMID: 31469332.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'. Eur J Med Chem. 2019 Oct 01; 179:765-778. Pereira GAN, da Silva EB, Braga SFP, Leite PG, Martins LC, Vieira RP, Soh WT, Villela FS, Costa FMR, Ray D, de Andrade SF, Brandstetter H, Oliveira RB, Caffrey CR, Machado FS, Ferreira RS. PMID: 31284086.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics. PLoS One. 2019; 14(6):e0217019. Abriola L, Hoyer D, Caffrey CR, Williams DL, Yoshino TP, Vermeire JJ. PMID: 31158236.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    19. Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni. Front Cell Infect Microbiol. 2019; 9:180. Probst A, Nguyen TN, El-Sakkary N, Skinner D, Suzuki BM, Buckner FS, Gelb MH, Caffrey CR, Debnath A. PMID: 31192168.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    20. Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents. PLoS Negl Trop Dis. 2019 02; 13(2):e0007129. Klug DM, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Gomez-Pérez V, Ruiz-Pérez LM, Rojas-Barros DI, Gamarro F, González-Pacanowska D, Martínez-Martínez MS, Manzano P, Ferrins L, Caffrey CR, Navarro M, Pollastri MP. PMID: 30735501.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment. J R Soc Interface. 2019 01 31; 16(150):20180675. Zhang S, Skinner D, Joshi P, Criado-Hidalgo E, Yeh YT, Lasheras JC, Caffrey CR, Del Alamo JC. PMID: 30958153.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    22. A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response. PLoS Negl Trop Dis. 2019 01; 13(1):e0007070. Soloviova K, Fox EC, Dalton JP, Caffrey CR, Davies SJ. PMID: 30653492.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. High Throughput and Computational Repurposing for Neglected Diseases. Pharm Res. 2018 Dec 17; 36(2):27. Hernandez HW, Soeung M, Zorn KM, Ashoura N, Mottin M, Andrade CH, Caffrey CR, de Siqueira-Neto JL, Ekins S. PMID: 30560386.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):571-586. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. PMID: 30503203.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    25. Cysteine proteases as digestive enzymes in parasitic helminths. PLoS Negl Trop Dis. 2018 08; 12(8):e0005840. Caffrey CR, Goupil L, Rebello KM, Dalton JP, Smith D. PMID: 30138310.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    26. Cysteine proteases during larval migration and development of helminths in their final host. PLoS Negl Trop Dis. 2018 08; 12(8):e0005919. Grote A, Caffrey CR, Rebello KM, Smith D, Dalton JP, Lustigman S. PMID: 30138448.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    27. Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis. ChemMedChem. 2018 09 06; 13(17):1751-1754. Monti L, Wang SC, Oukoloff K, Smith AB, Brunden KR, Caffrey CR, Ballatore C. PMID: 29969537.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    28. Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development. Dis Model Mech. 2018 07 30; 11(7). El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P. PMID: 29925529.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    29. Effect of Phenotypic Screening of Extracts and Fractions of Erythrophleum ivorense Leaf and Stem Bark on Immature and Adult Stages of Schistosoma mansoni. J Parasitol Res. 2018; 2018:9431467. Kyere-Davies G, Agyare C, Boakye YD, Suzuki BM, Caffrey CR. PMID: 29977614.
      View in: PubMed   Mentions:
    30. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. PLoS Negl Trop Dis. 2018 04; 12(4):e0006446. Leontovyc A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvorák J, Horn M. PMID: 29677188.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    31. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. PMID: 29725596.
      View in: PubMed   Mentions:
    32. Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing. Sci Rep. 2018 01 17; 8(1):975. Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey CR, Liachko NF. PMID: 29343694.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    33. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. PMID: 28704396.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Targeting proteasomes in infectious organisms to combat disease. FEBS J. 2017 05; 284(10):1503-1517. Bibo-Verdugo B, Jiang Z, Caffrey CR, O'Donoghue AJ. PMID: 28122162.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    35. Anthelmintics: From discovery to resistance II (San Diego, 2016). Int J Parasitol Drugs Drug Resist. 2016 12; 6(3):297-298. Martin RJ, Wolstenholme AJ, Caffrey CR. PMID: 27814986.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    36. Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation. PLoS Negl Trop Dis. 2016 Sep; 10(9):e0004930. Picard MA, Boissier J, Roquis D, Grunau C, Allienne JF, Duval D, Toulza E, Arancibia N, Caffrey CR, Long T, Nidelet S, Rohmer M, Cosseau C. PMID: 27677173.
      View in: PubMed   Mentions: 13     Fields:    
    37. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 07; 12(7):e1005763. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. PMID: 27467575.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    38. Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo. Pharmaceuticals (Basel). 2016 Jul 04; 9(3). Vermeire JJ, Suzuki BM, Caffrey CR. PMID: 27384569.
      View in: PubMed   Mentions:
    39. Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis. IEEE/ACM Trans Comput Biol Bioinform. 2018 Mar-Apr; 15(2):469-481. Singh R, Beasley R, Long T, Caffrey CR. PMID: 27071187.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    40. Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004357. Silveira AM, Costa EG, Ray D, Suzuki BM, Hsieh MH, Fraga LA, Caffrey CR. PMID: 26752073.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    41. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004356. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. PMID: 26751972.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    42. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. 2016 Mar; 122:99-109. Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. PMID: 26409899.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    43. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2015 Jun 25; 6:7485. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. PMID: 26108372.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    44. Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni. Molecules. 2015 Jun 12; 20(6):10873-83. Glaser J, Schurigt U, Suzuki BM, Caffrey CR, Holzgrabe U. PMID: 26076109.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015; 9(6):e0003827. Fajtová P, Štefanic S, Hradilek M, Dvorák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M. PMID: 26039195.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. PMID: 25712353.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Anthelmintic drug discovery: into the future. J Parasitol. 2015 Apr; 101(2):125-33. Geary TG, Sakanari JA, Caffrey CR. PMID: 25584662.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    48. Schistosomiasis and its treatment. Future Med Chem. 2015; 7(6):675-6. Caffrey CR. PMID: 25996057.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    49. The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens. Bioinformatics. 2015 May 01; 31(9):1515-8. Asarnow D, Rojo-Arreola L, Suzuki BM, Caffrey CR, Singh R. PMID: 25540182.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    50. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure. 2014 Dec 02; 22(12):1786-1798. Jílková A, Horn M, Rezácová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M. PMID: 25456815.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    51. Serum albumin and a-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib. Int J Parasitol Drugs Drug Resist. 2014 Dec; 4(3):287-95. Beckmann S, Long T, Scheld C, Geyer R, Caffrey CR, Grevelding CG. PMID: 25516839.
      View in: PubMed   Mentions: 11     Fields:    
    52. Regulation of Schistosoma mansoni development and reproduction by the mitogen-activated protein kinase signaling pathway. PLoS Negl Trop Dis. 2014 Jun; 8(6):e2949. Andrade LF, Mourão Mde M, Geraldo JA, Coelho FS, Silva LL, Neves RH, Volpini A, Machado-Silva JR, Araujo N, Nacif-Pimenta R, Caffrey CR, Oliveira G. PMID: 24945272.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    53. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2766. Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey CR, Dvorák J. PMID: 24676141.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    54. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One. 2014; 9(1):e87594. Rojo-Arreola L, Long T, Asarnow D, Suzuki BM, Singh R, Caffrey CR. PMID: 24489942.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    55. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec; 57(12):6063-73. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR. PMID: 24060869.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    56. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. PMID: 23875031.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    57. New insights into the machinery of blood digestion by ticks. Trends Parasitol. 2013 Jun; 29(6):276-85. Sojka D, Franta Z, Horn M, Caffrey CR, Mareš M, Kopácek P. PMID: 23664173.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    58. A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. PLoS Negl Trop Dis. 2012; 6(12):e1942. Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC. PMID: 23236535.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    59. Cure of hookworm infection with a cysteine protease inhibitor. PLoS Negl Trop Dis. 2012; 6(7):e1680. Vermeire JJ, Lantz LD, Caffrey CR. PMID: 22802972.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    60. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. PMID: 22539347.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    61. Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. Int J Parasitol. 2012 May 01; 42(5):481-8. Steverding D, Sexton DW, Wang X, Gehrke SS, Wagner GK, Caffrey CR. PMID: 22549023.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    62. Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics. 2012; 13 Suppl 1:S4. Lee H, Moody-Davis A, Saha U, Suzuki BM, Asarnow D, Chen S, Arkin M, Caffrey CR, Singh R. PMID: 22369037.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    63. Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1368. Abdulla MH, Lim KC, McKerrow JH, Caffrey CR. PMID: 22039561.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    64. Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery. Trends Parasitol. 2011 Dec; 27(12):555-64. Swain MT, Larkin DM, Caffrey CR, Davies SJ, Loukas A, Skelly PJ, Hoffmann KF. PMID: 22024648.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    65. Schistosomiasis: from drug deployment to drug development. Curr Opin Infect Dis. 2011 Oct; 24(5):410-7. Caffrey CR, Secor WE. PMID: 21734570.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    66. Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. J Biol Chem. 2011 Oct 14; 286(41):35770-81. Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mares M. PMID: 21832058.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    67. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol. 2011 Oct; 41(12):1253-62. Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P. PMID: 21819989.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    68. Mapping the pro-peptide of the Schistosoma mansoni cathepsin B1 drug target: modulation of inhibition by heparin and design of mimetic inhibitors. ACS Chem Biol. 2011 Jun 17; 6(6):609-17. Horn M, Jílková A, Vondrásek J, Maresová L, Caffrey CR, Mares M. PMID: 21375333.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    69. Cysteine peptidases of kinetoplastid parasites. Adv Exp Med Biol. 2011; 712:84-99. Caffrey CR, Lima AP, Steverding D. PMID: 21660660.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    70. Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection. BMC Immunol. 2010 Nov 15; 11:56. de Oliveira Fraga LA, Lamb EW, Moreno EC, Chatterjee M, Dvorák J, Delcroix M, Sajid M, Caffrey CR, Davies SJ. PMID: 21078176.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    71. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis. 2010 Oct 19; 4(10):e850. Stefanic S, Dvorák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey CR. PMID: 20976050.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    72. From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop. 2011 Sep; 120 Suppl 1:S121-37. Utzinger J, N'goran EK, Caffrey CR, Keiser J. PMID: 20831855.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsPHPublic Health
    73. Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasit Vectors. 2010 Jul 27; 3:63. Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey CR, Daffre S. PMID: 20663211.
      View in: PubMed   Mentions: 12     Fields:    
    74. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem. 2009 Nov 26; 52(22):7192-210. Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. PMID: 19848405.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    75. Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Mol Biochem Parasitol. 2010 Mar; 170(1):37-40. Dvorák J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey CR. PMID: 19914302.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    76. Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol. 2009 Oct 30; 16(10):1053-63. Horn M, Nussbaumerová M, Sanda M, Kovárová Z, Srba J, Franta Z, Sojka D, Bogyo M, Caffrey CR, Kopácek P, Mares M. PMID: 19875079.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    77. Structure-guided development of selective TbcatB inhibitors. J Med Chem. 2009 Oct 22; 52(20):6489-93. Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. PMID: 19769357.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    78. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. PMID: 19620707.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    79. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16; 460(7253):352-8. Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM. PMID: 19606141.
      View in: PubMed   Mentions: 390     Fields:    Translation:Animals
    80. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis. 2009 Jul 14; 3(7):e478. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey CR. PMID: 19597541.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    81. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009 Jun 02; 3(6):e449. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. PMID: 19488406.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    82. Kinetoplastid papain-like cysteine peptidases. Mol Biochem Parasitol. 2009 Sep; 167(1):12-9. Caffrey CR, Steverding D. PMID: 19409421.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    83. A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One. 2009; 4(2):e4413. Caffrey CR, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM. PMID: 19198654.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    84. Chapter 4. Peptidases of trematodes. Adv Parasitol. 2009; 69:205-97. Kasný M, Mikes L, Hampl V, Dvorák J, Caffrey CR, Dalton JP, Horák P. PMID: 19622410.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    85. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. PMID: 18701454.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    86. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 08; 51(9):2816-32. Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. PMID: 18416543.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    87. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 01; 18(9):2883-5. Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. PMID: 18420405.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    88. Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasit Vectors. 2008 Mar 18; 1(1):7. Sojka D, Franta Z, Horn M, Hajdusek O, Caffrey CR, Mares M, Kopácek P. PMID: 18348719.
      View in: PubMed   Mentions: 24     Fields:    
    89. Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Expert Opin Drug Discov. 2008 Feb; 3(2):173-86. Caffrey CR, Steverding D. PMID: 23480221.
      View in: PubMed   Mentions: 11     Fields:    
    90. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14; 51(3):545-52. Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. PMID: 18173229.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    91. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem. 2008 Apr 11; 283(15):9896-908. Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. PMID: 18160404.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    92. Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2008 Feb; 90(2):345-58. Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH. PMID: 17936488.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    93. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Lett. 2007 Sep 04; 581(22):4260-4. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K. PMID: 17707374.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    94. Chemotherapy of schistosomiasis: present and future. Curr Opin Chem Biol. 2007 Aug; 11(4):433-9. Caffrey CR. PMID: 17652008.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimals
    95. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell. 2007 Jul; 6(7):1130-6. Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL. PMID: 17513563.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    96. Proteomic analysis of adult S. mansoni gut contents. Mol Biochem Parasitol. 2007 Jul; 154(1):95-7. Delcroix M, Medzihradsky K, Caffrey CR, Fetter RD, McKerrow JH. PMID: 17451823.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    97. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72. Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. PMID: 17371810.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    98. The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo. Kinetoplastid Biol Dis. 2007 Feb 28; 6:2. Scory S, Stierhof YD, Caffrey CR, Steverding D. PMID: 17328798.
      View in: PubMed   Mentions:
    99. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol. 2007 Jun; 37(7):713-24. Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. PMID: 17336985.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    100. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med. 2007 Jan; 4(1):e14. Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR. PMID: 17214506.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    101. A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. J Biol Chem. 2006 Dec 22; 281(51):39316-29. Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH. PMID: 17028179.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    102. Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design. Mini Rev Med Chem. 2006 Sep; 6(9):1025-32. Steverding D, Caffrey CR, Sajid M. PMID: 17018001.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    103. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol Chem. 2006 Aug; 387(8):1053-61. Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey CR, McKerrow JH, Pike RN, Spithill TW. PMID: 16895475.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    104. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett. 2006 May 15; 16(10):2753-7. Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. PMID: 16516467.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    105. Proteases in parasitic diseases. Annu Rev Pathol. 2006; 1:497-536. McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M. PMID: 18039124.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimals
    106. Genomic and proteomic approaches for Chagas' disease: critical analysis of diagnostic methods. Expert Rev Mol Diagn. 2005 Jul; 5(4):521-30. Huete-Pérez JA, Flores-Obando RE, Ghedin E, Caffrey CR. PMID: 16013970.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    107. Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition. Int J Parasitol. 2005 Jul; 35(8):895-910. Dvorák J, Delcroix M, Rossi A, Vopálenský V, Pospísek M, Sedinová M, Mikes L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey CR. PMID: 15950230.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    108. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors. Biol Chem. 2005 Apr; 386(4):339-49. Caffrey CR, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondrásek J. PMID: 15899696.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    109. Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. Int J Parasitol. 2005 May; 35(6):583-9. Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey CR. PMID: 15862572.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    110. Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. Bioorg Med Chem. 2004 Oct 01; 12(19):5203-11. Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC. PMID: 15351403.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    111. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 15163200.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    112. Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 2004 May; 20(5):241-8. Caffrey CR, McKerrow JH, Salter JP, Sajid M. PMID: 15105025.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    113. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 08; 47(8):1889-92. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. PMID: 15055989.
      View in: PubMed   Mentions: 16     Fields:    
    114. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec; 384(12):1613-8. James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. PMID: 14719804.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    115. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003 Sep; 131(1):65-75. Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. PMID: 12967713.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    116. Improved trypanocidal activities of cathepsin L inhibitors. Int J Antimicrob Agents. 2003 Aug; 22(2):155-9. Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D. PMID: 12927956.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    117. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20; 45(13):2695-707. Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. PMID: 12061873.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    118. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. PMID: 11985866.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    119. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30; 121(1):49-61. Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. PMID: 11985862.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    120. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31. Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. PMID: 11932146.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    121. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol. 2001 Nov; 118(1):61-73. Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. PMID: 11704274.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    122. Aryl ureas represent a new class of anti-trypanosomal agents. Chem Biol. 2000 Sep; 7(9):733-42. Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. PMID: 10980453.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    123. Cysteine proteinases of trypanosome parasites: novel targets for chemotherapy. Curr Drug Targets. 2000 Sep; 1(2):155-62. Caffrey CR, Scory S, Steverding D. PMID: 11465068.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    124. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Lett. 2000 Jan 28; 466(2-3):244-8. Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. PMID: 10682836.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    125. Schistosoma japonicum is less sensitive to cyclosporin A in vivo than Schistosoma mansoni. J Parasitol. 1999 Aug; 85(4):736-9. Caffrey CR, Gsell C, Ruppel A. PMID: 10461959.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    126. Cysteine protease inhibitors as chemotherapy for parasitic infections. Bioorg Med Chem. 1999 Apr; 7(4):639-44. McKerrow JH, Engel JC, Caffrey CR. PMID: 10353643.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    127. Trypanosoma brucei: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-phe-ala-CHN2. Exp Parasitol. 1999 Apr; 91(4):327-33. Scory S, Caffrey CR, Stierhof YD, Ruppel A, Steverding D. PMID: 10092476.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    128. Schistosoma haematobium, S. intercalatum, S. japonicum, S. mansoni, and S. rodhaini in mice: relationship between patterns of lung migration by schistosomula and perfusion recovery of adult worms. Parasitol Res. 1998; 84(4):338-42. Rheinberg CE, Moné H, Caffrey CR, Imbert-Establet D, Jourdane J, Ruppel A. PMID: 9569102.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    129. [Studies on cathepsins in Schistosoma japonicum]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1998; 16(2):101-4. Li Y, Fen Y, Caffrey C, Ruppel A. PMID: 12078215.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    130. Affinity isolation and characterization of the cathepsin B-like proteinase Sj31 from Schistosoma japonicum. J Parasitol. 1997 Dec; 83(6):1112-8. Caffrey CR, Ruppel A. PMID: 9406788.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    131. Schistosoma japonicum, S. mansoni, S. haematobium, S. intercalatum, and S. rodhaini: cysteine-class cathepsin activities in the vomitus of adult worms. Parasitol Res. 1997; 83(1):37-41. Caffrey CR, Rheinberg CE, Moné H, Jourdane J, Li YL, Ruppel A. PMID: 9000231.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    132. Cathepsin B-like activity predominates over cathepsin L-like activity in adult Schistosoma mansoni and S. japonicum. Parasitol Res. 1997; 83(6):632-5. Caffrey CR, Ruppel A. PMID: 9211519.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    133. Characterisation of proteolytic activity of excretory-secretory products from adult Strongylus vulgaris. Vet Parasitol. 1994 Apr; 52(3-4):285-96. Caffrey CR, Ryan MF. PMID: 8073612.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    134. HLA-DP and coeliac disease: family and population studies. Gut. 1990 Jun; 31(6):663-7. Caffrey C, Hitman GA, Niven MJ, Cassell PG, Kumar P, Fry L, Mackintosh P, Gallagher R, Feighery C, Weir D. PMID: 1974234.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    135. Susceptibility to coeliac disease involves genes in HLA-DP region. Lancet. 1987 Oct 03; 2(8562):805. Niven MJ, Caffrey C, Sachs JA, Cassell PG, Gallagher RB, Kumar P, Hitman GA. PMID: 2889025.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    Conor's Networks
    Concepts (435)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (44)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _
    ↑