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Conor Caffrey

Title(s)Professor In Residence, School of Pharmacy and Pharmaceutical Science
SchoolHealth Sciences
Address9500 Gilman Drive #0755
La Jolla CA 92093
Phone858-534-5340
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    Collapse Research 
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    Translational development of cysteine protease inhibitors to treat hookworm disease
    NIH/NIAID R21AI142452Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Reasoning with chemically induced dynamic phenotypes in whole-organism assays
    NIH/NIAID R21AI146719Jun 1, 2019 - May 31, 2021
    Role: Co-Principal Investigator
    Brain Penetrant Microtubule-Stabilizers to Treat CNS-invasive Parasitic Diseases
    NIH/NIAID R21AI141210Feb 1, 2019 - Jan 31, 2021
    Role: Co-Principal Investigator
    Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseases
    NIH/NIAID R21AI133394Jun 1, 2018 - May 31, 2020
    Role: Principal Investigator
    Defining the death transcriptome of Schistosoma mansoni to construct a molecular drug screen
    NIH/NIAID R21AI126296Feb 20, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Exploring statins as a small molecule therapy for treatment of schistosomiasis
    NIH/NIAID R21AI107390Jun 5, 2013 - May 31, 2015
    Role: Principal Investigator
    An automated high throughput phenotypic screen for schistosomiasis drug discovery
    NIH/NIAID R01AI089896May 15, 2010 - Apr 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors. J Enzyme Inhib Med Chem. 2020 Dec; 35(1):1387-1402. Corrigan TS, Lotti Diaz LM, Border SE, Ratigan SC, Kasper KQ, Sojka D, Fajtova P, Caffrey CR, Salvesen GS, McElroy CA, Hadad CM, Dogan Ekici Ö. PMID: 32633155.
      View in: PubMed   Mentions:    Fields:    
    2. Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2020 Jul 24; 11(1):3779. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, McQuibban GA, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. PMID: 32709866.
      View in: PubMed   Mentions:    Fields:    
    3. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone. J Antimicrob Chemother. 2020 Jul 02. Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta AP, Skinner DE, El-Sakkary N, Momper JD, Gangoiti J, Dong Y, Vennerstrom JL, Charman SA, Caffrey CR, Keiser J. PMID: 32617557.
      View in: PubMed   Mentions:    Fields:    
    4. Uncovering biological application of Brazilian green propolis: a phenotypic screening against Schistosoma mansoni. Chem Biodivers. 2020 Jun 23. de L Paula LA, Santos MF, Pagotti MC, Faleiros R, Ramos HP, Veneziani RC, Bastos JK, Caffrey CR, Ambrósio SR, Guidi Magalhães L. PMID: 32578329.
      View in: PubMed   Mentions:    Fields:    
    5. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Negl Trop Dis. 2020 03; 14(3):e0008150. Ehrenkaufer G, Li P, Stebbins EE, Kangussu-Marcolino MM, Debnath A, White CV, Moser MS, DeRisi J, Gisselberg J, Yeh E, Wang SC, Company AH, Monti L, Caffrey CR, Huston CD, Wang B, Singh U. PMID: 32196500.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin. Front Cell Infect Microbiol. 2020; 10:66. Dvoráková H, Leontovyc R, Machácek T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L. PMID: 32175287.
      View in: PubMed   Mentions:    Fields:    
    7. Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity. Sci Rep. 2020 Feb 13; 10(1):2587. Ferraro F, Corvo I, Bergalli L, Ilarraz A, Cabrera M, Gil J, Susuki BM, Caffrey CR, Timson DJ, Robert X, Guillon C, Freire T, Álvarez G. PMID: 32054976.
      View in: PubMed   Mentions:    Fields:    
    8. Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty. Pharmaceuticals (Basel). 2020 02 03; 13(2). Singh S, El-Sakkary N, Skinner DE, Sharma PP, Ottilie S, Antonova-Koch Y, Kumar P, Winzeler E, Caffrey CR, Rathi B. PMID: 32028743.
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    9. Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni. ACS Med Chem Lett. 2020 Mar 12; 11(3):258-265. Buskes MJ, Clements M, Bachovchin KA, Jalani HB, Leonard A, Bag S, Klug DM, Singh B, Campbell RF, Sciotti RJ, El-Sakkary N, Caffrey CR, Pollastri MP, Ferrins L. PMID: 32184954.
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    10. Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis. J Med Chem. 2020 Jan 23; 63(2):756-783. Tear WF, Bag S, Diaz-Gonzalez R, Ceballos-Pérez G, Rojas-Barros DI, Cordon-Obras C, Pérez-Moreno G, García-Hernández R, Martinez-Martinez MS, Ruiz-Perez LM, Gamarro F, Gonzalez Pacanowska D, Caffrey CR, Ferrins L, Manzano P, Navarro M, Pollastri MP. PMID: 31846577.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics. J Med Chem. 2020 Mar 12; 63(5):2527-2546. Klug DM, Tschiegg L, Diaz R, Rojas-Barros D, Perez-Moreno G, Ceballos G, García-Hernández R, Martinez-Martinez MS, Manzano P, Ruiz LM, Caffrey CR, Gamarro F, Pacanowska DG, Ferrins L, Navarro M, Pollastri MP. PMID: 31670951.
      View in: PubMed   Mentions: 1     Fields:    
    12. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 11; 63(11). O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. PMID: 31451503.
      View in: PubMed   Mentions: 2     Fields:    
    13. Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery. Parasit Vectors. 2019 Oct 22; 12(1):493. Maccesi M, Aguiar PHN, Pasche V, Padilla M, Suzuki BM, Montefusco S, Abagyan R, Keiser J, Mourão MM, Caffrey CR. PMID: 31640761.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    14. The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni. ACS Infect Dis. 2019 10 11; 5(10):1802-1812. Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. PMID: 31355632.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain). Parasit Vectors. 2019 Jul 30; 12(1):383. Chaimon S, Limpanont Y, Reamtong O, Ampawong S, Phuphisut O, Chusongsang P, Ruangsittichai J, Boonyuen U, Watthanakulpanich D, O'Donoghue AJ, Caffrey CR, Adisakwattana P. PMID: 31362766.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    16. Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei. Future Med Chem. 2019 07; 11(13):1537-1551. Pereira GA, Santos LH, Wang SC, Martins LC, Villela FS, Liao W, Dessoy MA, Dias LC, Andricopulo AD, Costa MA, Nagem RA, Caffrey CR, Liedl KR, Caffarena ER, Ferreira RS. PMID: 31469332.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'. Eur J Med Chem. 2019 Oct 01; 179:765-778. Pereira GAN, da Silva EB, Braga SFP, Leite PG, Martins LC, Vieira RP, Soh WT, Villela FS, Costa FMR, Ray D, de Andrade SF, Brandstetter H, Oliveira RB, Caffrey CR, Machado FS, Ferreira RS. PMID: 31284086.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics. PLoS One. 2019; 14(6):e0217019. Abriola L, Hoyer D, Caffrey CR, Williams DL, Yoshino TP, Vermeire JJ. PMID: 31158236.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    19. Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni. Front Cell Infect Microbiol. 2019; 9:180. Probst A, Nguyen TN, El-Sakkary N, Skinner D, Suzuki BM, Buckner FS, Gelb MH, Caffrey CR, Debnath A. PMID: 31192168.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    20. Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents. PLoS Negl Trop Dis. 2019 02; 13(2):e0007129. Klug DM, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Gomez-Pérez V, Ruiz-Pérez LM, Rojas-Barros DI, Gamarro F, González-Pacanowska D, Martínez-Martínez MS, Manzano P, Ferrins L, Caffrey CR, Navarro M, Pollastri MP. PMID: 30735501.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment. J R Soc Interface. 2019 01 31; 16(150):20180675. Zhang S, Skinner D, Joshi P, Criado-Hidalgo E, Yeh YT, Lasheras JC, Caffrey CR, Del Alamo JC. PMID: 30958153.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    22. A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response. PLoS Negl Trop Dis. 2019 01; 13(1):e0007070. Soloviova K, Fox EC, Dalton JP, Caffrey CR, Davies SJ. PMID: 30653492.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. High Throughput and Computational Repurposing for Neglected Diseases. Pharm Res. 2018 Dec 17; 36(2):27. Hernandez HW, Soeung M, Zorn KM, Ashoura N, Mottin M, Andrade CH, Caffrey CR, de Siqueira-Neto JL, Ekins S. PMID: 30560386.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):571-586. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. PMID: 30503203.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    25. Cysteine proteases as digestive enzymes in parasitic helminths. PLoS Negl Trop Dis. 2018 08; 12(8):e0005840. Caffrey CR, Goupil L, Rebello KM, Dalton JP, Smith D. PMID: 30138310.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    26. Cysteine proteases during larval migration and development of helminths in their final host. PLoS Negl Trop Dis. 2018 08; 12(8):e0005919. Grote A, Caffrey CR, Rebello KM, Smith D, Dalton JP, Lustigman S. PMID: 30138448.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    27. Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis. ChemMedChem. 2018 09 06; 13(17):1751-1754. Monti L, Wang SC, Oukoloff K, Smith AB, Brunden KR, Caffrey CR, Ballatore C. PMID: 29969537.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    28. Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development. Dis Model Mech. 2018 07 30; 11(7). El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P. PMID: 29925529.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    29. Effect of Phenotypic Screening of Extracts and Fractions of Erythrophleum ivorense Leaf and Stem Bark on Immature and Adult Stages of Schistosoma mansoni. J Parasitol Res. 2018; 2018:9431467. Kyere-Davies G, Agyare C, Boakye YD, Suzuki BM, Caffrey CR. PMID: 29977614.
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    30. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. PLoS Negl Trop Dis. 2018 04; 12(4):e0006446. Leontovyc A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvorák J, Horn M. PMID: 29677188.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    31. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. PMID: 29725596.
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    32. Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing. Sci Rep. 2018 01 17; 8(1):975. Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey CR, Liachko NF. PMID: 29343694.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    33. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. PMID: 28704396.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Targeting proteasomes in infectious organisms to combat disease. FEBS J. 2017 05; 284(10):1503-1517. Bibo-Verdugo B, Jiang Z, Caffrey CR, O'Donoghue AJ. PMID: 28122162.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    35. Anthelmintics: From discovery to resistance II (San Diego, 2016). Int J Parasitol Drugs Drug Resist. 2016 12; 6(3):297-298. Martin RJ, Wolstenholme AJ, Caffrey CR. PMID: 27814986.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    36. Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation. PLoS Negl Trop Dis. 2016 Sep; 10(9):e0004930. Picard MA, Boissier J, Roquis D, Grunau C, Allienne JF, Duval D, Toulza E, Arancibia N, Caffrey CR, Long T, Nidelet S, Rohmer M, Cosseau C. PMID: 27677173.
      View in: PubMed   Mentions: 13     Fields:    
    37. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 07; 12(7):e1005763. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. PMID: 27467575.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    38. Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo. Pharmaceuticals (Basel). 2016 Jul 04; 9(3). Vermeire JJ, Suzuki BM, Caffrey CR. PMID: 27384569.
      View in: PubMed   Mentions:
    39. Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis. IEEE/ACM Trans Comput Biol Bioinform. 2018 Mar-Apr; 15(2):469-481. Singh R, Beasley R, Long T, Caffrey CR. PMID: 27071187.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    40. Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004357. Silveira AM, Costa EG, Ray D, Suzuki BM, Hsieh MH, Fraga LA, Caffrey CR. PMID: 26752073.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    41. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004356. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. PMID: 26751972.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    42. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. 2016 Mar; 122:99-109. Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. PMID: 26409899.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    43. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2015 Jun 25; 6:7485. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. PMID: 26108372.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    44. Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni. Molecules. 2015 Jun 12; 20(6):10873-83. Glaser J, Schurigt U, Suzuki BM, Caffrey CR, Holzgrabe U. PMID: 26076109.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015; 9(6):e0003827. Fajtová P, Štefanic S, Hradilek M, Dvorák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M. PMID: 26039195.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. PMID: 25712353.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Anthelmintic drug discovery: into the future. J Parasitol. 2015 Apr; 101(2):125-33. Geary TG, Sakanari JA, Caffrey CR. PMID: 25584662.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    48. Schistosomiasis and its treatment. Future Med Chem. 2015; 7(6):675-6. Caffrey CR. PMID: 25996057.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    49. The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens. Bioinformatics. 2015 May 01; 31(9):1515-8. Asarnow D, Rojo-Arreola L, Suzuki BM, Caffrey CR, Singh R. PMID: 25540182.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    50. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure. 2014 Dec 02; 22(12):1786-1798. Jílková A, Horn M, Rezácová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M. PMID: 25456815.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    51. Serum albumin and a-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib. Int J Parasitol Drugs Drug Resist. 2014 Dec; 4(3):287-95. Beckmann S, Long T, Scheld C, Geyer R, Caffrey CR, Grevelding CG. PMID: 25516839.
      View in: PubMed   Mentions: 11     Fields:    
    52. Regulation of Schistosoma mansoni development and reproduction by the mitogen-activated protein kinase signaling pathway. PLoS Negl Trop Dis. 2014 Jun; 8(6):e2949. Andrade LF, Mourão Mde M, Geraldo JA, Coelho FS, Silva LL, Neves RH, Volpini A, Machado-Silva JR, Araujo N, Nacif-Pimenta R, Caffrey CR, Oliveira G. PMID: 24945272.
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    119. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30; 121(1):49-61. Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. PMID: 11985862.
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    120. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31. Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. PMID: 11932146.
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    121. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol. 2001 Nov; 118(1):61-73. Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. PMID: 11704274.
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    122. Aryl ureas represent a new class of anti-trypanosomal agents. Chem Biol. 2000 Sep; 7(9):733-42. Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. PMID: 10980453.
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    123. Cysteine proteinases of trypanosome parasites: novel targets for chemotherapy. Curr Drug Targets. 2000 Sep; 1(2):155-62. Caffrey CR, Scory S, Steverding D. PMID: 11465068.
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    124. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Lett. 2000 Jan 28; 466(2-3):244-8. Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. PMID: 10682836.
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    125. Schistosoma japonicum is less sensitive to cyclosporin A in vivo than Schistosoma mansoni. J Parasitol. 1999 Aug; 85(4):736-9. Caffrey CR, Gsell C, Ruppel A. PMID: 10461959.
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    126. Cysteine protease inhibitors as chemotherapy for parasitic infections. Bioorg Med Chem. 1999 Apr; 7(4):639-44. McKerrow JH, Engel JC, Caffrey CR. PMID: 10353643.
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    127. Trypanosoma brucei: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-phe-ala-CHN2. Exp Parasitol. 1999 Apr; 91(4):327-33. Scory S, Caffrey CR, Stierhof YD, Ruppel A, Steverding D. PMID: 10092476.
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    128. Schistosoma haematobium, S. intercalatum, S. japonicum, S. mansoni, and S. rodhaini in mice: relationship between patterns of lung migration by schistosomula and perfusion recovery of adult worms. Parasitol Res. 1998; 84(4):338-42. Rheinberg CE, Moné H, Caffrey CR, Imbert-Establet D, Jourdane J, Ruppel A. PMID: 9569102.
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    129. [Studies on cathepsins in Schistosoma japonicum]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1998; 16(2):101-4. Li Y, Fen Y, Caffrey C, Ruppel A. PMID: 12078215.
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    130. Affinity isolation and characterization of the cathepsin B-like proteinase Sj31 from Schistosoma japonicum. J Parasitol. 1997 Dec; 83(6):1112-8. Caffrey CR, Ruppel A. PMID: 9406788.
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    131. Schistosoma japonicum, S. mansoni, S. haematobium, S. intercalatum, and S. rodhaini: cysteine-class cathepsin activities in the vomitus of adult worms. Parasitol Res. 1997; 83(1):37-41. Caffrey CR, Rheinberg CE, Moné H, Jourdane J, Li YL, Ruppel A. PMID: 9000231.
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    132. Cathepsin B-like activity predominates over cathepsin L-like activity in adult Schistosoma mansoni and S. japonicum. Parasitol Res. 1997; 83(6):632-5. Caffrey CR, Ruppel A. PMID: 9211519.
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    133. Characterisation of proteolytic activity of excretory-secretory products from adult Strongylus vulgaris. Vet Parasitol. 1994 Apr; 52(3-4):285-96. Caffrey CR, Ryan MF. PMID: 8073612.
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    134. HLA-DP and coeliac disease: family and population studies. Gut. 1990 Jun; 31(6):663-7. Caffrey C, Hitman GA, Niven MJ, Cassell PG, Kumar P, Fry L, Mackintosh P, Gallagher R, Feighery C, Weir D. PMID: 1974234.
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    135. Susceptibility to coeliac disease involves genes in HLA-DP region. Lancet. 1987 Oct 03; 2(8562):805. Niven MJ, Caffrey C, Sachs JA, Cassell PG, Gallagher RB, Kumar P, Hitman GA. PMID: 2889025.
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