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Conor Caffrey

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    Translational development of cysteine protease inhibitors to treat hookworm disease
    NIH/NIAID R21AI142452Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Reasoning with chemically induced dynamic phenotypes in whole-organism assays
    NIH/NIAID R21AI146719Jun 1, 2019 - May 31, 2021
    Role: Co-Principal Investigator
    Brain Penetrant Microtubule-Stabilizers to Treat CNS-invasive Parasitic Diseases
    NIH R21AI141210Feb 1, 2019 - Jan 31, 2021
    Role: Co-Principal Investigator
    Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseases
    NIH R21AI133394Jun 1, 2018 - May 31, 2021
    Role: Principal Investigator
    Defining the death transcriptome of Schistosoma mansoni to construct a molecular drug screen
    NIH/NIAID R21AI126296Feb 20, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Exploring statins as a small molecule therapy for treatment of schistosomiasis
    NIH R21AI107390Jun 5, 2013 - May 31, 2016
    Role: Principal Investigator
    An automated high throughput phenotypic screen for schistosomiasis drug discovery
    NIH R01AI089896May 15, 2010 - Apr 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site. ACS Omega. 2025 Jul 29; 10(29):31549-31567. Border SE, Lotti Diaz LM, Amer R, Noonchester AM, Kucway KS, Fleisher M, Fernandez JP, Lovins AR, Corrigan TS, Serrano AK, Caffrey CR, O'Donoghue AJ, Benson DM, Hadad CM, Dogan Ekici Ö. PMID: 40757351; PMCID: PMC12311731.
      View in: PubMed   Mentions:
    2. Chalcogen Derivatives for the Treatment of African Trypanosomiasis: Biological Evaluation of Thio- and Seleno-Semicarbazones and Their Azole Derivatives. ACS Omega. 2025 Jun 17; 10(23):24872-24886. Rubio-Hernández M, Teixeira TR, Nguyen TP, Shingyoji M, da Silva EB, O'Donoghue AJ, Caffrey CR, Pérez-Silanes S, Martínez-Sáez N. PMID: 40547650; PMCID: PMC12177781.
      View in: PubMed   Mentions:
    3. Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates. Protein Sci. 2025 Jun; 34(6):e70180. Silva EB, Jiang Z, Liu C, Fajtová P, Teixeira TR, de Castro Fiorini Maia G, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ. PMID: 40411405; PMCID: PMC12102734.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    4. Identification of Substituted 4-Aminocinnolines as Broad-Spectrum Antiparasitic Agents. ACS Infect Dis. 2025 Mar 14; 11(3):584-599. Spaulding A, Sharma A, Giardini MA, Hoffman B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Millard CC, Devine WG, Singh B, Silva EM, Leed SE, Roncal NE, Penn EC, Erath J, Kumar G, Sepulveda Y, Garcia A, Rodriguez A, El-Sakkary N, Sciotti RJ, Campbell RF, Momper JD, McKerrow JH, Caffrey CR, Siqueira-Neto JL, Pollastri MP, Mensa-Wilmot K, Ferrins L. PMID: 39936822; PMCID: PMC11915375.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome. Protein Sci. 2024 Dec; 33(12):e5225. Fajtova P, Hurysz BM, Miyamoto Y, Serafim MSM, Jiang Z, Vazquez JM, Trujillo DF, Liu LJ, Somani U, Almaliti J, Myers SA, Caffrey CR, Gerwick WH, McMinn DL, Kirk CJ, Boura E, Eckmann L, O'Donoghue AJ. PMID: 39589076; PMCID: PMC11590128.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease. Eur J Med Chem. 2025 Feb 05; 283:117109. Nunes JA, Santos-Júnior PFDS, Gomes MC, Ferreira LAS, Padilha EKA, Teixeira TR, Stanger EJ, Kaur Y, Silva EBD, Costa CACB, Freitas JD, Araújo-Júnior JX, Mendonça-Junior FJB, Giardini MA, Siqueira-Neto JL, Caffrey CR, Zhan P, Cardoso SH, Silva-Júnior EFD. PMID: 39653622.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship and In Vivo Efficacy. ACS Infect Dis. 2024 Dec 13; 10(12):4182-4193. Liu LJ, Francisco KR, Sun YU, Serafim MSM, Amarasinghe DK, Teixeira TR, Lucero B, Kronenberger T, Elsayed W, Elwakeel H, Al-Hindy M, Almaliti J, Gerwick WH, O'Donoghue AJ, Caffrey CR. PMID: 39589805; PMCID: PMC11650654.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    8. Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities. Results Chem. 2024 Dec; 12. Dawoodjee AM, Sichinga J, Banda H, Mbaya S, Funjika E, Mayoka G, Hikaambo C, Francisco KR, Sun YU, Liu LJ, Caffrey CR, Cheuka PM. PMID: 40129570; PMCID: PMC11932705.
      View in: PubMed   Mentions:
    9. Computational Workflow to Design Novel Vaccine Candidates and Small-Molecule Therapeutics for Schistosomiasis. Pathogens. 2024 Sep 30; 13(10). Balogun EO, Joseph GI, Olabode SC, Dayaso NA, Danazumi AU, Bashford-Rogers R, Mckerrow JH, Jeelani G, Caffrey CR. PMID: 39452722; PMCID: PMC11509903.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. The proteasome as a drug target for treatment of parasitic diseases. Adv Parasitol. 2024; 126:53-96. Liu LJ, O'Donoghue AJ, Caffrey CR. PMID: 39448194.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    11. Clickable Probes for Pathogen Proteasomes: Synthesis and Applications. ACS Omega. 2024 Aug 13; 9(32):34829-34840. Liu LJ, Lucero B, Manriquez-Rodriguez C, Francisco KR, Teixeira TR, Yohannan DJ, Ballatore C, Myers SA, O'Donoghue AJ, Caffrey CR. PMID: 39157084; PMCID: PMC11325529.
      View in: PubMed   Mentions: 1  
    12. The Kavaratamides: Discovery of Linear Lipodepsipeptides from the Marine Cyanobacterium Moorena bouillonii Using a Comparative Chemogeographic Analysis. J Nat Prod. 2024 06 28; 87(6):1601-1610. Ryu B, Glukhov E, Teixeira TR, Caffrey CR, Madiyan S, Joseph V, Avalon NE, Leber CA, Naman CB, Gerwick WH. PMID: 38832890; PMCID: PMC11217931.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Pharmacophore Virtual Screening Identifies Riboflavin as an Inhibitor of the Schistosome Cathepsin B1 Protease with Antiparasitic Activity. ACS Omega. 2024 Jun 11; 9(23):25356-25369. Cogo RM, Pavani TFA, Mengarda ACA, Cajas RA, Teixeira TR, Fukui-Silva L, Sun YU, Liu LJ, Amarasinghe DK, Yoon MC, Santos-Filho OA, de Moraes J, Caffrey CR, G G Rando D. PMID: 38882094; PMCID: PMC11170711.
      View in: PubMed   Mentions: 1  
    14. Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis. ACS Infect Dis. 2024 Jun 14; 10(6):1935-1948. Spiwoková P, Horn M, Fanfrlík J, Jílková A, Fajtová P, Leontovyc A, Houštecká R, Bieliková L, Brynda J, Chanová M, Mertlíková-Kaiserová H, Caro-Diaz EJE, Almaliti J, El-Sakkary N, Gerwick WH, Caffrey CR, Mareš M. PMID: 38757505; PMCID: PMC11184554.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Tractable Quinolone Hydrazides Exhibiting Sub-Micromolar and Broad Spectrum Antitrypanosomal Activities. ChemMedChem. 2024 05 02; 19(9):e202300667. Chirwa KA, Francisco KR, Dube PS, Park H, Legoabe LJ, Teixeira TR, Caffrey CR, Beteck RM. PMID: 38326914; PMCID: PMC11076157.
      View in: PubMed   Mentions:
    16. Development of subunit selective proteasome substrates for Schistosoma species. bioRxiv. 2024 Feb 14. Jiang Z, Silva EB, Liu C, Fajtová P, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ. PMID: 38405969; PMCID: PMC10888821.
      View in: PubMed   Mentions:
    17. Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies. ChemMedChem. 2024 04 16; 19(8):e202300656. Lucero B, Francisco KR, Varricchio C, Liu LJ, Yao Y, Brancale A, Brunden KR, Caffrey CR, Ballatore C. PMID: 38277231; PMCID: PMC11031298.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Biomechanics of parasite migration within hosts. Trends Parasitol. 2024 02; 40(2):164-175. Yeh YT, Del Álamo JC, Caffrey CR. PMID: 38172015.
      View in: PubMed   Mentions:
    19. Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines. Parasitol Res. 2023 Dec; 122(12):2751-2772. Saidu U, Ibrahim MA, de Koning HP, McKerrow JH, Caffrey CR, Balogun EO. PMID: 37851179.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    20. Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. ACS Pharmacol Transl Sci. 2023 Nov 10; 6(11):1651-1658. Francisco KR, Bruystens J, Varricchio C, McCurdy S, Wu J, Lopez-Ramirez MA, Ginsberg M, Caffrey CR, Brancale A, Gingras AR, Hixon MS, Ballatore C. PMID: 37974623; PMCID: PMC10644391.
      View in: PubMed   Mentions: 3  
    21. Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis. ChemMedChem. 2023 10 17; 18(20):e202300193. Monti L, Liu LJ, Varricchio C, Lucero B, Alle T, Yang W, Bem-Shalom I, Gilson M, Brunden KR, Brancale A, Caffrey CR, Ballatore C. PMID: 37429821; PMCID: PMC10615688.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Protein-protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies. Trends Pharmacol Sci. 2023 07; 44(7):474-488. Lucero B, Francisco KR, Liu LJ, Caffrey CR, Ballatore C. PMID: 37263826; PMCID: PMC11003449.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    23. Seaweeds and Corals from the Brazilian Coast: Review on Biotechnological Potential and Environmental Aspects. Molecules. 2023 May 23; 28(11). Dos Santos GS, de Souza TL, Teixeira TR, Brandão JPC, Santana KA, Barreto LHS, Cunha SS, Dos Santos DCMB, Caffrey CR, Pereira NS, de Freitas Santos Júnior A. PMID: 37298760; PMCID: PMC10254870.
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    24. Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022. ACS Infect Dis. 2023 05 12; 9(5):1046-1055. Caldwell N, Afshar R, Baragaña B, Bustinduy AL, Caffrey CR, Collins JJ, Fusco D, Garba A, Gardner M, Gomes M, Hoffmann KF, Hsieh M, Lo NC, McNamara CW, Nono JK, Padalino G, Read KD, Roestenberg M, Spangenberg T, Specht S, Gilbert IH. PMID: 37083395; PMCID: PMC10186373.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    25. Development of subunit selective substrates for Trichomonas vaginalis proteasome. bioRxiv. 2023 Apr 06. Fajtova P, Hurysz BM, Miyamoto Y, Serafim M, Jiang Z, Trujillo DF, Liu L, Somani U, Almaliti J, Myers SA, Caffrey CR, Gerwick WH, Kirk CJ, Boura E, Eckmann L, O'Donoghue AJ. PMID: 37066163; PMCID: PMC10104049.
      View in: PubMed   Mentions:
    26. Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5- a ]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis. bioRxiv. 2023 Mar 11. Monti L, Liu LJ, Varricchio C, Lucero B, Alle T, Yang W, Bem-Shalom I, Gilson M, Brunden KR, Brancale A, Caffrey CR, Ballatore C. PMID: 36945407; PMCID: PMC10028969.
      View in: PubMed   Mentions:
    27. Activity of N-phenylbenzamide analogs against the neglected disease pathogen, Schistosoma mansoni. Bioorg Med Chem Lett. 2023 02 15; 82:129164. Kanyanta M, Lengwe C, Mambwe D, Francisco KR, Liu LJ, Uli Sun Y, Amarasinghe DK, Caffrey CR, Mubanga Cheuka P. PMID: 36736493; PMCID: PMC10072318.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei. Bioorg Med Chem Lett. 2023 02 01; 81:129123. Francisco KR, Monti L, Yang W, Park H, Liu LJ, Watkins K, Amarasinghe DK, Nalli M, Roberto Polaquini C, Regasini LO, Eduardo Miller Crotti A, Silvestri R, Guidi Magalhães L, Caffrey CR. PMID: 36608774; PMCID: PMC10072319.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. Microtubule-Stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal New Structure-Activity Insights. J Med Chem. 2023 01 12; 66(1):435-459. Alle T, Varricchio C, Yao Y, Lucero B, Nzou G, Demuro S, Muench M, Vuong KD, Oukoloff K, Cornec AS, Francisco KR, Caffrey CR, Lee VM, Smith AB, Brancale A, Brunden KR, Ballatore C. PMID: 36534051; PMCID: PMC9841533.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling Using Leishmania donovani. Pathogens. 2022 Nov 26; 11(12). Hayat O, Ullah N, Sirajuddin M, Giardini MA, Nguyen JV, Francisco KR, Liu LJ, Sun YU, Maurya S, McGrosso D, Gonzalez DJ, Caffrey CR, Debnath A, Siqueira-Neto JL. PMID: 36558759; PMCID: PMC9785441.
      View in: PubMed   Mentions: 3     Fields:    
    31. From rational design to serendipity: Discovery of novel thiosemicarbazones as potent trypanocidal compounds. Eur J Med Chem. 2022 Dec 15; 244:114876. Braga SFP, Santos VC, Vieira RP, Silva EBD, Monti L, Krake SH, Martinez PDG, Dias LC, Caffrey CR, Siqueira-Neto JL, de Oliveira RB, Ferreira RS. PMID: 36343429.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    32. Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain. ACS Med Chem Lett. 2022 Nov 10; 13(11):1715-1722. Mathavan I, Liu LJ, Robinson SW, El-Sakkary N, Elatico AJJ, Gomez D, Nellas R, Owens RJ, Zuercher W, Navratilova I, Caffrey CR, Beis K. PMID: 36385939; PMCID: PMC9661718.
      View in: PubMed   Mentions: 3  
    33. EF24, a schistosomicidal curcumin analog: Insights from its synthesis and phenotypic, biochemical and cytotoxic activities. Chem Biol Interact. 2022 Dec 01; 368:110191. Badoco FR, Paula LAL, Orenha RP, Mendes TMF, Squarisi IS, El-Sakkary N, Loiola MC, Katz N, Tavares DC, Sairre MI, Parreira RLT, Janku Cabral F, Alegretti SM, Caffrey CR, Magalhães LG. PMID: 36181831.
      View in: PubMed   Mentions:
    34. Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions. ACS Omega. 2022 Jul 26; 7(29):25346-25352. Phan VV, Mosier C, Yoon MC, Glukhov E, Caffrey CR, O'Donoghue AJ, Gerwick WH, Hook V. PMID: 35910167; PMCID: PMC9330179.
      View in: PubMed   Mentions: 5  
    35. Designing and development of phthalimides as potent anti-tubulin hybrid molecules against malaria. Eur J Med Chem. 2022 Sep 05; 239:114534. Singh V, Hada RS, Jain R, Vashistha M, Kumari G, Singh S, Sharma N, Bansal M, Zoltner M, Caffrey CR, Rathi B, Singh S. PMID: 35749989.
      View in: PubMed   Mentions:
    36. Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation. PLoS Pathog. 2022 03; 18(3):e1010309. Yeh YT, Skinner DE, Criado-Hidalgo E, Chen NS, Garcia-De Herreros A, El-Sakkary N, Liu L, Zhang S, Kandasamy A, Chien S, Lasheras JC, Del Álamo JC, Caffrey CR. PMID: 35316298; PMCID: PMC8939816.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    37. Brazilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine model. Parasitol Res. 2022 Feb; 121(2):775-780. de L Paula LA, Santos MFC, Pagotti MC, Veneziani RCS, Bastos JK, Caffrey CR, Ambrósio SR, Magalhães LG. PMID: 35048211.
      View in: PubMed   Mentions:
    38. Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. Eur J Med Chem. 2021 Dec 15; 226:113823. Padalino G, El-Sakkary N, Liu LJ, Liu C, Harte DSG, Barnes RE, Sayers E, Forde-Thomas J, Whiteland H, Bassetto M, Ferla S, Johnson G, Jones AT, Caffrey CR, Chalmers I, Brancale A, Hoffmann KF. PMID: 34536671; PMCID: PMC8626775.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    39. Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors. J Med Chem. 2021 09 09; 64(17):13054-13071. Barbosa da Silva E, Rocha DA, Fortes IS, Yang W, Monti L, Siqueira-Neto JL, Caffrey CR, McKerrow J, Andrade SF, Ferreira RS. PMID: 34461718.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. Antiparasitic Properties of Propolis Extracts and Their Compounds. Chem Biodivers. 2021 Sep; 18(9):e2100310. de L Paula LA, Cândido ACBB, Santos MFC, Caffrey CR, Bastos JK, Ambrósio SR, Magalhães LG. PMID: 34231306.
      View in: PubMed   Mentions:
    41. Should the enzyme name 'rhodesain' be discontinued? Mol Biochem Parasitol. 2021 09; 245:111395. Steverding D, Caffrey CR. PMID: 34246720.
      View in: PubMed   Mentions:
    42. Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis. J Med Chem. 2021 07 08; 64(13):9404-9430. Klug DM, Mavrogiannaki EM, Forbes KC, Silva L, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Garcia-Hernández R, Bosch-Navarrete C, Cordón-Obras C, Gómez-Liñán C, Saura A, Momper JD, Martinez-Martinez MS, Manzano P, Syed A, El-Sakkary N, Caffrey CR, Gamarro F, Ruiz-Perez LM, Gonzalez Pacanowska D, Ferrins L, Navarro M, Pollastri MP. PMID: 34156862; PMCID: PMC8412142.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    43. Correction to: Understanding the key processes of excellence as a prerequisite to establishing academic centres of excellence in Africa. BMC Med Educ. 2021 Feb 10; 21(1):97. Fekadu A, Oppenheim C, Manyazewal T, Nislow C, Woldeamanuel Y, Hailu A, Belete A, Wondimagegn D, Hanlon C, Gebremariam T, Collins A, Larson CJ, Gebreyes W, Aklilu E, Muula AS, Mugus S, Caffrey CR, Giday M, Yimer G, Davey G, Medhin G, Makonnen E. PMID: 33568098; PMCID: PMC7877084.
      View in: PubMed   Mentions:
    44. A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules. ACS Infect Dis. 2021 02 12; 7(2):406-420. Zorn KM, Sun S, McConnon CL, Ma K, Chen EK, Foil DH, Lane TR, Liu LJ, El-Sakkary N, Skinner DE, Ekins S, Caffrey CR. PMID: 33434015; PMCID: PMC7887754.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    45. Understanding the key processes of excellence as a prerequisite to establishing academic centres of excellence in Africa. BMC Med Educ. 2021 Jan 07; 21(1):36. Fekadu A, Oppenheim C, Manyazewal T, Nislow C, Woldeamanuel Y, Hailu A, Belete A, Wondimagegn D, Hanlon C, Gebremariam T, Collins A, Larson CJ, Gebreyes W, Aklilu E, Muula AS, Mugus S, Caffrey CR, Giday M, Yimer G, Davey G, Medhin G, Makonnen E. PMID: 33413297; PMCID: PMC7792348.
      View in: PubMed   Mentions:
    46. A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery. Commun Biol. 2020 12 21; 3(1):747. Chen S, Suzuki BM, Dohrmann J, Singh R, Arkin MR, Caffrey CR. PMID: 33349640; PMCID: PMC7752906.
      View in: PubMed   Mentions: 9  Translation:Animals
    47. Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity. ACS Infect Dis. 2021 01 08; 7(1):189-201. Jílková A, Horn M, Fanfrlík J, Küppers J, Pachl P, Rezácová P, Lepšík M, Fajtová P, Rubešová P, Chanová M, Caffrey CR, Gütschow M, Mareš M. PMID: 33301315; PMCID: PMC7802074.
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    48. Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors. J Enzyme Inhib Med Chem. 2020 Dec; 35(1):1387-1402. Corrigan TS, Lotti Diaz LM, Border SE, Ratigan SC, Kasper KQ, Sojka D, Fajtova P, Caffrey CR, Salvesen GS, McElroy CA, Hadad CM, Dogan Ekici Ö. PMID: 32633155; PMCID: PMC7470110.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    49. Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors. ACS Infect Dis. 2021 05 14; 7(5):1077-1088. Jílková A, Rubešová P, Fanfrlík J, Fajtová P, Rezácová P, Brynda J, Lepšík M, Mertlíková-Kaiserová H, Emal CD, Renslo AR, Roush WR, Horn M, Caffrey CR, Mareš M. PMID: 33175511; PMCID: PMC8154419.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    50. Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro. ACS Infect Dis. 2021 05 14; 7(5):1089-1103. Monti L, Cornec AS, Oukoloff K, Kovalevich J, Prijs K, Alle T, Brunden KR, Smith AB, El-Sakkary N, Liu LJ, Syed A, Skinner DE, Ballatore C, Caffrey CR. PMID: 33135408; PMCID: PMC8641298.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    51. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone. J Antimicrob Chemother. 2020 10 01; 75(10):2925-2932. Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta AP, Skinner DE, El-Sakkary N, Momper JD, Gangoiti J, Dong Y, Vennerstrom JL, Charman SA, Caffrey CR, Keiser J. PMID: 32617557; PMCID: PMC7556815.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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