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    Conor Caffrey

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0755
    CA La Jolla 92093
    Phone858-534-5340
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Defining the death transcriptome of Schistosoma mansoni to construct a molecular drug screen
      NIH/NIAID R21AI126296Feb 20, 2017 - Jan 31, 2019
      Role: Principal Investigator
      Exploring statins as a small molecule therapy for treatment of schistosomiasis
      NIH/NIAID R21AI107390Jun 5, 2013 - May 31, 2015
      Role: Principal Investigator
      An automated high throughput phenotypic screen for schistosomiasis drug discovery
      NIH/NIAID R01AI089896May 15, 2010 - Apr 30, 2014
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey C. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. PMID: 28704396.
        View in: PubMed
      2. Bibo-Verdugo B, Jiang Z, Caffrey C, O'Donoghue AJ. Targeting proteasomes in infectious organisms to combat disease. FEBS J. 2017 Jan 25. PMID: 28122162.
        View in: PubMed
      3. Martin RJ, Wolstenholme AJ, Caffrey C. Anthelmintics: From discovery to resistance II (San Diego, 2016). Int J Parasitol Drugs Drug Resist. 2016 Sep 29. PMID: 27814986.
        View in: PubMed
      4. Picard MA, Boissier J, Roquis D, Grunau C, Allienne JF, Duval D, Toulza E, Arancibia N, Caffrey C, Long T, Nidelet S, Rohmer M, Cosseau C. Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation. PLoS Negl Trop Dis. 2016 Sep; 10(9):e0004930. PMID: 27677173.
        View in: PubMed
      5. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey C, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 Jul; 12(7):e1005763. PMID: 27467575.
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      6. Vermeire JJ, Suzuki BM, Caffrey C. Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo. Pharmaceuticals (Basel). 2016; 9(3). PMID: 27384569.
        View in: PubMed
      7. Singh R, Beasley R, Long T, Caffrey C. Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis. IEEE/ACM Trans Comput Biol Bioinform. 2016 Apr 07. PMID: 27071187.
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      8. Silveira AM, Costa EG, Ray D, Suzuki BM, Hsieh MH, Fraga LA, Caffrey C. Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004357. PMID: 26752073.
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      9. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey C. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004356. PMID: 26751972.
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      10. Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey C, O'Donoghue AJ. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. 2016 Mar; 122:99-109. PMID: 26409899.
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      11. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey C, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2015; 6:7485. PMID: 26108372.
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      12. Glaser J, Schurigt U, Suzuki BM, Caffrey C, Holzgrabe U. Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni. Molecules. 2015; 20(6):10873-83. PMID: 26076109.
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      13. Fajtová P, Štefanic S, Hradilek M, Dvorák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey C, Mareš M, Horn M. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015 Jun; 9(6):e0003827. PMID: 26039195.
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      14. Caffrey C. Schistosomiasis and its treatment. Future Med Chem. 2015 Apr; 7(6):675-6. PMID: 25996057.
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      15. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey C, de Oliveira RB, Ferreira RS. Synthesis of a Sugar-Based Thiosemicarbazone Series and Structure-Activity Relationship versus the Parasite Cysteine Proteases Rhodesain, Cruzain, and Schistosoma mansoni Cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. PMID: 25712353.
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      16. Geary TG, Sakanari JA, Caffrey C. Anthelmintic drug discovery: into the future. J Parasitol. 2015 Apr; 101(2):125-33. PMID: 25584662.
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      17. Asarnow D, Rojo-Arreola L, Suzuki BM, Caffrey C, Singh R. The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens. Bioinformatics. 2015 May 1; 31(9):1515-8. PMID: 25540182.
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      18. Jílková A, Horn M, Rezácová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey C, Mareš M. Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch. Structure. 2014 Dec 2; 22(12):1786-98. PMID: 25456815.
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      19. Beckmann S, Long T, Scheld C, Geyer R, Caffrey C, Grevelding CG. Serum albumin and a-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib. Int J Parasitol Drugs Drug Resist. 2014 Dec; 4(3):287-95. PMID: 25516839.
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      20. Andrade LF, Mourão Mde M, Geraldo JA, Coelho FS, Silva LL, Neves RH, Volpini A, Machado-Silva JR, Araujo N, Nacif-Pimenta R, Caffrey C, Oliveira G. Regulation of Schistosoma mansoni development and reproduction by the mitogen-activated protein kinase signaling pathway. PLoS Negl Trop Dis. 2014 Jun; 8(6):e2949. PMID: 24945272.
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      21. Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey C, Dvorák J. Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni - 'The Undiscovered Country'. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2766. PMID: 24676141.
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      22. Rojo-Arreola L, Long T, Asarnow D, Suzuki BM, Singh R, Caffrey C. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One. 2014; 9(1):e87594. PMID: 24489942.
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      23. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey C. A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection. Antimicrob Agents Chemother. 2013 Dec; 57(12):6063-73. PMID: 24060869.
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      24. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey C, Tort JF. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. PMID: 23875031.
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      25. Sojka D, Franta Z, Horn M, Caffrey C, Mareš M, Kopácek P. New insights into the machinery of blood digestion by ticks. Trends Parasitol. 2013 Jun; 29(6):276-85. PMID: 23664173.
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      26. Mashiyama ST, Koupparis K, Caffrey C, McKerrow JH, Babbitt PC. A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. PLoS Negl Trop Dis. 2012; 6(12):e1942. PMID: 23236535.
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      27. Vermeire JJ, Lantz LD, Caffrey C. Cure of hookworm infection with a cysteine protease inhibitor. PLoS Negl Trop Dis. 2012; 6(7):e1680. PMID: 22802972.
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      28. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey C, McKerrow JH, Mares M, Kopácek P. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. PMID: 22539347.
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      29. Steverding D, Sexton DW, Wang X, Gehrke SS, Wagner GK, Caffrey C. Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target. Int J Parasitol. 2012 May 1; 42(5):481-8. PMID: 22549023.
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      30. Lee H, Moody-Davis A, Saha U, Suzuki BM, Asarnow D, Chen S, Arkin M, Caffrey C, Singh R. Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics. 2012; 13 Suppl 1:S4. PMID: 22369037.
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      31. Abdulla MH, Lim KC, McKerrow JH, Caffrey C. Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1368. PMID: 22039561.
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      32. Swain MT, Larkin DM, Caffrey C, Davies SJ, Loukas A, Skelly PJ, Hoffmann KF. Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery. Trends Parasitol. 2011 Dec; 27(12):555-64. PMID: 22024648.
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      33. Caffrey C, Secor WE. Schistosomiasis: from drug deployment to drug development. Curr Opin Infect Dis. 2011 Oct; 24(5):410-7. PMID: 21734570.
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      34. Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey C, Mares M. Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. J Biol Chem. 2011 Oct 14; 286(41):35770-81. PMID: 21832058.
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      35. Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey C, Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol. 2011 Oct; 41(12):1253-62. PMID: 21819989.
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      36. Horn M, Jílková A, Vondrásek J, Maresová L, Caffrey C, Mares M. Mapping the pro-peptide of the Schistosoma mansoni cathepsin B1 drug target: modulation of inhibition by heparin and design of mimetic inhibitors. ACS Chem Biol. 2011 Jun 17; 6(6):609-17. PMID: 21375333.
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      37. Caffrey C, Lima AP, Steverding D. Cysteine peptidases of kinetoplastid parasites. Adv Exp Med Biol. 2011; 712:84-99. PMID: 21660660.
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      38. de Oliveira Fraga LA, Lamb EW, Moreno EC, Chatterjee M, Dvorák J, Delcroix M, Sajid M, Caffrey C, Davies SJ. Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection. BMC Immunol. 2010; 11:56. PMID: 21078176.
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      39. Stefanic S, Dvorák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey C. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis. 2010; 4(10):e850. PMID: 20976050.
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      40. Utzinger J, N'goran EK, Caffrey C, Keiser J. From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop. 2011 Sep; 120 Suppl 1:S121-37. PMID: 20831855.
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      41. Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey C, Daffre S. Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasit Vectors. 2010; 3:63. PMID: 20663211.
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      42. Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey C, Powers JC. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem. 2009 Nov 26; 52(22):7192-210. PMID: 19848405.
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      43. Dvorák J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey C. Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Mol Biochem Parasitol. 2010 Mar; 170(1):37-40. PMID: 19914302.
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      44. Horn M, Nussbaumerová M, Sanda M, Kovárová Z, Srba J, Franta Z, Sojka D, Bogyo M, Caffrey C, Kopácek P, Mares M. Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol. 2009 Oct 30; 16(10):1053-63. PMID: 19875079.
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      45. Mallari JP, Shelat AA, Kosinski A, Caffrey C, Connelly M, Zhu F, McKerrow JH, Guy RK. Structure-guided development of selective TbcatB inhibitors. J Med Chem. 2009 Oct 22; 52(20):6489-93. PMID: 19769357.
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      46. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey C, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. PMID: 19620707.
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      47. Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey C, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16; 460(7253):352-8. PMID: 19606141.
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      48. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey C. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis. 2009; 3(7):e478. PMID: 19597541.
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      49. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey C. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009; 3(6):e449. PMID: 19488406.
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      50. Caffrey C, Steverding D. Kinetoplastid papain-like cysteine peptidases. Mol Biochem Parasitol. 2009 Sep; 167(1):12-9. PMID: 19409421.
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      51. Caffrey C, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM. A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One. 2009; 4(2):e4413. PMID: 19198654.
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      52. Kasný M, Mikes L, Hampl V, Dvorák J, Caffrey C, Dalton JP, Horák P. Chapter 4. Peptidases of trematodes. Adv Parasitol. 2009; 69:205-97. PMID: 19622410.
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      53. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey C, McKerrow JH. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. PMID: 18701454.
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      54. Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey C, Powers JC. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8; 51(9):2816-32. PMID: 18416543.
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      55. Mallari JP, Shelat A, Kosinski A, Caffrey C, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 1; 18(9):2883-5. PMID: 18420405.
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      56. Sojka D, Franta Z, Horn M, Hajdusek O, Caffrey C, Mares M, Kopácek P. Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasit Vectors. 2008; 1(1):7. PMID: 18348719.
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      57. Caffrey C, Steverding D. Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Expert Opin Drug Discov. 2008 Feb; 3(2):173-86. PMID: 23480221.
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      58. Mallari JP, Shelat AA, Obrien T, Caffrey C, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14; 51(3):545-52. PMID: 18173229.
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      59. Stack CM, Caffrey C, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem. 2008 Apr 11; 283(15):9896-908. PMID: 18160404.
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      60. Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey C, McKerrow JH. Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2008 Feb; 90(2):345-58. PMID: 17936488.
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      61. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Lett. 2007 Sep 4; 581(22):4260-4. PMID: 17707374.
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      62. Caffrey C. Chemotherapy of schistosomiasis: present and future. Curr Opin Chem Biol. 2007 Aug; 11(4):433-9. PMID: 17652008.
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      63. Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey C, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell. 2007 Jul; 6(7):1130-6. PMID: 17513563.
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      64. Delcroix M, Medzihradsky K, Caffrey C, Fetter RD, McKerrow JH. Proteomic analysis of adult S. mansoni gut contents. Mol Biochem Parasitol. 2007 Jul; 154(1):95-7. PMID: 17451823.
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      65. Caffrey C, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72. PMID: 17371810.
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      66. Scory S, Stierhof YD, Caffrey C, Steverding D. The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo. Kinetoplastid Biol Dis. 2007; 6:2. PMID: 17328798.
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      82. James KE, Götz MG, Caffrey C, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec; 384(12):1613-8. PMID: 14719804.
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      84. Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey C, Steverding D. Improved trypanocidal activities of cathepsin L inhibitors. Int J Antimicrob Agents. 2003 Aug; 22(2):155-9. PMID: 12927956.
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