Alexandra Newton

Photo of Alexandra Newton
Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Ph.D.Stanford University

    Collapse Research 
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    Aberrant Protein Kinase C Signaling in Alzheimer's Disease
    NIH R56AG082903Sep 15, 2023 - Aug 31, 2024
    Role: Principal Investigator
    Structural and Molecular Mechanisms for Dysregulation of Protein Kinase C Gamma in Cerebellar Ataxia
    NIH R01NS120725May 1, 2021 - Mar 31, 2031
    Role: Principal Investigator
    Establishing Function of Understudied PRKCQ Kinase in Cellular Regulation and Disease
    NIH R03TR002914Aug 20, 2019 - Aug 19, 2021
    Role: Principal Investigator
    Molecular Mechanisms of Cell Signaling
    NIH R35GM122523Jun 1, 2017 - May 31, 2027
    Role: Principal Investigator
    Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    NIH R01GM067946May 1, 2003 - Jan 31, 2017
    Role: Principal Investigator
    PROTEIN KINASE C: STRUCTURE/REGULATION/CELLULAR FUNCTION
    NIH R13CA085161Feb 7, 2000 - Feb 6, 2001
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH P01DK054441Dec 15, 1998 - Mar 31, 2019
    Role: Co-Investigator
    ON SIGNAL TRANSDUCTION AND LIPID SECOND MESSENGERS
    NIH R13GM057207Mar 1, 1998 - Feb 28, 1999
    Role: Principal Investigator
    PROTEIN KINASE C AND PHOTORECEPTORS
    NIH R01EY008820Aug 1, 1991 - Feb 28, 2004
    Role: Principal Investigator
    Structure, Function and Regulation of Protein Kinase C
    NIH R01GM043154Dec 1, 1989 - May 31, 2017
    Role: Principal Investigator
    Structure, Function and Regulation of Protein Kinase C
    NIH R37GM043154Dec 1, 1989 - Aug 31, 2013
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    EFFECT OF ACTIVATION ON MEMBRANE-BOUND PROTEIN KINASE C
    NIH F32GM011356Feb 14, 1987
    Role: Principal Investigator

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    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pseudokinase-converting mutation in protein kinase C alpha drives chordoid glioma by pathway rewiring. Proc Natl Acad Sci U S A. 2026 Jul 21; 123(29):e2524934123. Bellamy C, Tovell H, Kao TH, Kornev A, Letourneur Q, Arslan J, Schwaighofer S, Baffi TR, Dingli F, Loew D, Lerond J, Liva S, Izac B, Andrieu M, Adle-Biassette H, Barnier JV, Stefan E, Taylor SS, Sanson M, Newton AC, Bielle F. PMID: 42441840; PMCID: PMC13389638.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Suppression of AKT Activation Through LZK Inhibition Limits Tumor Growth in Esophageal and Head and Neck Cancers. Mol Cancer Ther. 2026 Jun 02. Katerji M, Rubin MR, Lindberg E, Torres-Ayuso P, Siddiqui A, Funk AL, Nyswaner K, Woodroofe CC, Wolfe S, Edwards ZC, Trotter EW, Baloglu E, Ahel I, Marusiak AA, Newton A, Cachau RE, Arnold K, Swenson RE, Brognard J. PMID: 42227584; PMCID: PMC13335793.
      View in: PubMed   Mentions:    Fields:    
    3. Protein kinase C theta: evolution, regulation, and function. Biochem J. 2026 May 06; 483(5):603-620. Hodapp SJ, Manning G, Newton AC. PMID: 41979916; PMCID: PMC13142937.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Sex-specific disruptions in PKCγ signaling in a mouse model of spinocerebellar ataxia type 14. JCI Insight. 2026 05 22; 11(10). Wolfe SA, Ma Y, Yaron-Barir TM, Chang C, Pilo CA, Ghassemian M, Roberts AJ, Lee SR, Henson BA, Jepsen K, Johnson JL, Cantley LC, Taylor SS, Gorrie G, Newton AC. PMID: 41926327; PMCID: PMC13232732.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases. J Biol Chem. 2025 12; 301(12):110921. Hodapp SJ, Kao TH, Wu J, Balasuriya N, Antal CE, Taylor SS, Newton AC. PMID: 41207627; PMCID: PMC12721161.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease. Sci Signal. 2025 Jul; 18(893):eadv0970. Gauron MC, Prokopenko D, Lee S, Wolfe SA, Hecker J, Willett J, Waqas M, Lordén G, Yang Y, Mayfield JE, Castanho I, Mullin K, Morgan S, Hahn G, Demeo DL, Hide W, Bertram L, Lange C, Newton AC, Tanzi RE. PMID: 40591711; PMCID: PMC12303577.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring. bioRxiv. 2025 May 31. Bellamy C, Tovell H, Schwaighofer S, Baffi TR, Arslan J, Letourneur Q, Dingli F, Loew D, Kornev A, Lerond J, Kao TH, Liva S, Izac B, Andrieu M, Adle-Biassette H, Barnier JV, Stefan E, Sanson M, Newton AC, Bielle F. PMID: 40501730; PMCID: PMC12154579.
      View in: PubMed   Mentions:
    8. Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance. medRxiv. 2025 May 14. Gauron MC, Prokopenko D, Lee S, Wolfe SA, Hecker J, Willett J, Waqas M, Lordén G, Yang Y, Mayfield JE, Castanho I, Mullin K, Morgan S, Hahn G, Demeo DL, Hide W, Bertram L, Lange C, Newton AC, Tanzi RE. PMID: 40463529; PMCID: PMC12132147.
      View in: PubMed   Mentions:
    9. Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice. J Clin Invest. 2025 May 15; 135(10). Lin J, Callender JA, Mayfield JE, McClatchy DB, Ojeda-Juárez D, Pourhamzeh M, Soldau K, Kurt TD, Danque GA, Khuu H, Ronson JE, Pizzo DP, Du Y, Gruber MA, Sevillano AM, Wang J, Orrú CD, Chen J, Funk G, Aguilar-Calvo P, Aulston BD, Roy S, Rho JM, Bui JD, Newton AC, Lipton SA, Caughey B, Patrick GN, Doré K, Yates JR, Sigurdson CJ. PMID: 40185484; PMCID: PMC12077891.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice. J Clin Invest. 2025 Apr 04. Lin J, Callender JA, Mayfield JE, McClatchy DB, Ojeda-Juárez D, Pourhamzeh M, Soldau K, Kurt TD, Danque GA, Khuu H, Ronson JE, Pizzo DP, Du Y, Gruber MA, Sevillano AM, Wang J, Orrú CD, Chen J, Funk G, Aguilar-Calvo P, Aulston BD, Roy S, Rho JM, Bui JD, Newton AC, Lipton SA, Caughey B, Patrick GN, Doré K, Yates JR, Sigurdson CJ. PMID: 40185484.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Novel C1A Domain Variant in Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 Decreases Autoinhibition. Cerebellum. 2025 Mar 18; 24(3):65. Raj Ghosh G, Kao TH, Steigerwald CG, Chan NL, Newton AC, Abreu NJ. PMID: 40100287; PMCID: PMC11991623.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Novel C1A Domain Variant in Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 Decreases Autoinhibition. Cerebellum. 2025 Mar 18; 24(3):65. Raj Ghosh G, Kao TH, Steigerwald CG, Chan NL, Newton AC, Abreu NJ. PMID: 40100287; PMCID: PMC11991623.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Sex specific disruptions in Protein Kinase Cγ signaling in a mouse model of Spinocerebellar Ataxia Type 14. bioRxiv. 2025 Feb 10. Wolfe SA, Ma Y, Pilo CA, Chang C, Ghassemian M, Roberts AJ, Lee SR, Gorrie G, Taylor SS, Newton AC. PMID: 39990445; PMCID: PMC11844395.
      View in: PubMed   Mentions:
    14. Sensitive fluorescent biosensor reveals differential subcellular regulation of PKC. Nat Chem Biol. 2025 04; 21(4):501-511. Su Q, Zhang J, Lin W, Zhang JF, Newton AC, Mehta S, Yang J, Zhang J. PMID: 39394268; PMCID: PMC12392915.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. Cancer-associated mutations in protein kinase C theta are loss-of-function. Biochem J. 2024 06 19; 481(12):759-775. Hodapp SJ, Gravel N, Kannan N, Newton AC. PMID: 38752473; PMCID: PMC11346454.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput. Nat Methods. 2024 Jun; 21(6):1033-1043. Kennedy PH, Alborzian Deh Sheikh A, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer CG, Alarcón S, Newby GA, Myers SA. PMID: 38684783; PMCID: PMC11804830.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    17. Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC. bioRxiv. 2024 Mar 30. Su Q, Zhang J, Lin W, Zhang JF, Newton AC, Mehta S, Yang J, Zhang J. PMID: 38586003; PMCID: PMC10996667.
      View in: PubMed   Mentions:
    18. Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput. bioRxiv. 2023 Nov 14. Kennedy PH, Deh Sheikh AA, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer C, Alarcón S, Newby G, Myers SA. PMID: 38014346; PMCID: PMC10680671.
      View in: PubMed   Mentions:
    19. Author Correction: Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol. 2023 Sep; 25(9):1385. Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. PMID: 37580389.
      View in: PubMed   Mentions:    Fields:    
    20. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. Biochem J. 2023 08 30; 480(16):1299-1316. Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. PMID: 37551632; PMCID: PMC10586763.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    22. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. bioRxiv. 2023 Mar 16. Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. PMID: 36993163; PMCID: PMC10055082.
      View in: PubMed   Mentions:
    23. Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer. IUBMB Life. 2023 Apr; 75(4):282-283. Newton AC, Alessi DR. PMID: 36905647.
      View in: PubMed   Mentions:    Fields:    
    24. Protein kinase C showcases allosteric control: activation of LRRK1. Biochem J. 2023 02 14; 480(3):219-223. Tovell H, Newton AC. PMID: 36762701; PMCID: PMC9987930.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    25. Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model. Nat Commun. 2022 11 23; 13(1):7200. Lordén G, Wozniak JM, Doré K, Dozier LE, Cates-Gatto C, Patrick GN, Gonzalez DJ, Roberts AJ, Tanzi RE, Newton AC. PMID: 36418293; PMCID: PMC9684486.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    26. Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition. Sci Signal. 2022 Sep 27; 15(753):eabk1147. Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, Newton AC. PMID: 36166510; PMCID: PMC9810342.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    27. Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration. Front Cell Dev Biol. 2022; 10:929510. Pilo CA, Newton AC. PMID: 35800893; PMCID: PMC9253466.
      View in: PubMed   Mentions: 8  
    28. Protein kinase C: release from quarantine by mTORC2. Trends Biochem Sci. 2022 06; 47(6):518-530. Baffi TR, Newton AC. PMID: 35361526; PMCID: PMC10936736.
      View in: PubMed   Mentions: 9     Fields:    Translation:CellsPHPublic Health
    29. PHLPP Signaling in Immune Cells. Curr Top Microbiol Immunol. 2022; 436:117-143. Lordén G, Lam AJ, Levings MK, Newton AC. PMID: 36243842.
      View in: PubMed   Mentions: 5     Fields:    
    30. Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment? Neuronal Signal. 2021 Dec; 5(4):NS20210036. Lordén G, Newton AC. PMID: 34737895; PMCID: PMC8536831.
      View in: PubMed   Mentions: 15  
    31. Particle release from refit operations in shipyards: Exposure, toxicity and environmental implications. Sci Total Environ. 2022 Jan 15; 804:150216. López M, López Lilao A, Ribalta C, Martínez Y, Piña N, Ballesteros A, Fito C, Koehler K, Newton A, Monfort E, Viana M. PMID: 34520930.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    32. mTOR Regulation of AGC Kinases: New Twist to an Old Tail. Mol Pharmacol. 2022 04; 101(4):213-218. Baffi TR, Newton AC. PMID: 34155089; PMCID: PMC9092464.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    33. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 04 13; 14(678). Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. PMID: 33850054; PMCID: PMC8208635.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    34. PKCα Is Recruited to Staphylococcus aureus-Containing Phagosomes and Impairs Bacterial Replication by Inhibition of Autophagy. Front Immunol. 2021; 12:662987. Gauron MC, Newton AC, Colombo MI. PMID: 33815423; PMCID: PMC8013776.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    35. Protein kinase C fusion proteins are paradoxically loss of function in cancer. J Biol Chem. 2021 Jan-Jun; 296:100445. Van AN, Kunkel MT, Baffi TR, Lordén G, Antal CE, Banerjee S, Newton AC. PMID: 33617877; PMCID: PMC8008189.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    36. PHLPPing the balance: restoration of protein kinase C in cancer. Biochem J. 2021 01 29; 478(2):341-355. Tovell H, Newton AC. PMID: 33502516; PMCID: PMC8086891.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    37. The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch. Mol Cell Biol. 2021 Feb 23; 41(3):e0033320. Kawashima AT, Wong C, Lordén G, King CC, Lara-Gonzalez P, Desai A, Gingras AC, Newton AC. PMID: 33397691; PMCID: PMC8088274.
      View in: PubMed   Mentions: 3     Fields:    
    38. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun. 2020 11 30; 11(1):6088. Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. PMID: 33257668; PMCID: PMC7705703.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    39. Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes. IUBMB Life. 2020 12; 72(12):2584-2590. Jones AC, Taylor SS, Newton AC, Kornev AP. PMID: 33166426; PMCID: PMC8086893.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    40. PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling. Annu Rev Pharmacol Toxicol. 2021 01 06; 61:723-743. Baffi TR, Cohen-Katsenelson K, Newton AC. PMID: 32997603; PMCID: PMC11003498.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    41. Pharmacology on Target. Trends Pharmacol Sci. 2020 04; 41(4):227-230. Kawashima AT, Newton AC. PMID: 32122673; PMCID: PMC11039263.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    42. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. Elife. 2019 08 13; 8. Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. PMID: 31408005; PMCID: PMC6692130.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    43. The PHLPP2 phosphatase is a druggable driver of prostate cancer progression. J Cell Biol. 2019 06 03; 218(6):1943-1957. Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, Trotman LC. PMID: 31092557; PMCID: PMC6548123.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    44. Protein kinases in tune. IUBMB Life. 2019 06; 71(6):670-671. Newton AC. PMID: 31059207.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer. Mol Cell. 2019 04 18; 74(2):378-392.e5. Baffi TR, Van AN, Zhao W, Mills GB, Newton AC. PMID: 30904392; PMCID: PMC6504549.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    46. Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol. 2019 03; 21(3):359-371. Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. PMID: 30804505; PMCID: PMC6546105.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    47. Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter. Sci Signal. 2019 01 01; 12(562). Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, Andrew McCammon J, Nakamura SI, Newton AC. PMID: 30600259; PMCID: PMC6657501.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    48. Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):E5497-E5505. Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC. PMID: 29844158; PMCID: PMC6004447.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    49. Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity. J Biol Chem. 2018 07 06; 293(27):10744-10756. Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P. PMID: 29773654; PMCID: PMC6036199.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    50. Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. Sci Rep. 2018 04 25; 8(1):6518. Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, Kannan N. PMID: 29695735; PMCID: PMC5916945.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    51. Protein kinase C: perfectly balanced. Crit Rev Biochem Mol Biol. 2018 04; 53(2):208-230. Newton AC. PMID: 29513138; PMCID: PMC5901981.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    52. Modelling the role of groundwater hydro-refugia in East African hominin evolution and dispersal. Nat Commun. 2017 05 30; 8:15696. Cuthbert MO, Gleeson T, Reynolds SC, Bennett MR, Newton AC, McCormack CJ, Ashley GM. PMID: 28556825; PMCID: PMC5460002.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    53. Protein kinase C as a tumor suppressor. Semin Cancer Biol. 2018 02; 48:18-26. Newton AC. PMID: 28476658; PMCID: PMC5668200.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    54. Conventional protein kinase C in the brain: 40 years later. Neuronal Signal. 2017 Apr; 1(2):NS20160005. Callender JA, Newton AC. PMID: 32714576; PMCID: PMC7373245.
      View in: PubMed   Mentions: 53  
    55. Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. Trends Pharmacol Sci. 2017 05; 38(5):438-447. Newton AC, Brognard J. PMID: 28283201; PMCID: PMC5403564.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    56. PHLPPing through history: a decade in the life of PHLPP phosphatases. Biochem Soc Trans. 2016 12 15; 44(6):1675-1682. Grzechnik AT, Newton AC. PMID: 27913677; PMCID: PMC5783572.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    57. KinView: a visual comparative sequence analysis tool for integrated kinome research. Mol Biosyst. 2016 11 15; 12(12):3651-3665. McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyers PA, Kannan N. PMID: 27731453; PMCID: PMC5508867.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    58. Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond). 2016 09 01; 130(17):1499-510. Newton AC, Antal CE, Steinberg SF. PMID: 27433023; PMCID: PMC5024564.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    59. Second Messengers. Cold Spring Harb Perspect Biol. 2016 08 01; 8(8). Newton AC, Bootman MD, Scott JD. PMID: 27481708; PMCID: PMC4968160.
      View in: PubMed   Mentions: 94     Fields:    Translation:Cells
    60. Bacterial spore coat protein kinases: A new twist to an old story. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):6811-2. Scott JD, Newton AC. PMID: 27286827; PMCID: PMC4922189.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    61. Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem. 2016 Jul 01; 291(27):13964-13973. Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Raza Ali S, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJP, Nizet V. PMID: 27226531; PMCID: PMC4933157.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    62. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016 05 10; 9(427):ra47. Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. PMID: 27165780; PMCID: PMC5154619.
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    63. Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease. Sci Signal. 2016 May 10; 9(427):pc11. Newton AC, Tanzi RE, VanHook AM. PMID: 27165779.
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    64. Protein Scaffolds Control Localized Protein Kinase Cζ Activity. J Biol Chem. 2016 Jun 24; 291(26):13809-22. Tobias IS, Newton AC. PMID: 27143478; PMCID: PMC4919463.
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    65. Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. Oncotarget. 2016 Apr 12; 7(15):20919-33. Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA. PMID: 26989024; PMCID: PMC4991501.
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    66. Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J. 2016 Feb 15; 473(4):509-23. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC. PMID: 26635352; PMCID: PMC4888060.
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    67. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Rep. 2015 Aug 25; 12(8):1252-60. Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. PMID: 26279568; PMCID: PMC4551583.
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    68. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 04; 290(36):21845-56. Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. PMID: 26187466; PMCID: PMC4571940.
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    69. Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. J Biol Chem. 2015 Jun 26; 290(26):16272-80. Bradley EW, Carpio LR, Newton AC, Westendorf JJ. PMID: 25953896; PMCID: PMC4481226.
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    70. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):E937-46. Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P. PMID: 25713130; PMCID: PMC4352799.
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    71. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29; 160(3):489-502. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. PMID: 25619690; PMCID: PMC4313737.
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    72. Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. Chem Biol. 2015 Jan 22; 22(1):98-106. Kunkel MT, Newton AC. PMID: 25556943; PMCID: PMC4311772.
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    73. Tuning the signalling output of protein kinase C. Biochem Soc Trans. 2014 Dec; 42(6):1477-83. Antal CE, Newton AC. PMID: 25399557; PMCID: PMC5783555.
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    74. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E3957-65. Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC. PMID: 25201979; PMCID: PMC4183331.
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    75. Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase. Biochemistry. 2014 Jun 24; 53(24):3971-81. Sierecki E, Newton AC. PMID: 24892992; PMCID: PMC4072346.
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    76. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 08; 54(3):378-91. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. PMID: 24703948; PMCID: PMC4019712.
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    77. Intramolecular conformational changes optimize protein kinase C signaling. Chem Biol. 2014 Apr 24; 21(4):459-469. Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. PMID: 24631122; PMCID: PMC4020788.
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    78. Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem. 2014 Mar 28; 289(13):8781-98. Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE. PMID: 24500718; PMCID: PMC3979370.
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    79. Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol. 2014; 54:537-58. Newton AC, Trotman LC. PMID: 24392697; PMCID: PMC4082184.
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    80. Imaging kinase activity at protein scaffolds. Methods Mol Biol. 2014; 1071:129-37. Kunkel MT, Newton AC. PMID: 24052385; PMCID: PMC4043534.
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    81. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics. 2013 Dec; 12(12):3498-508. Antal CE, Newton AC. PMID: 23788531; PMCID: PMC3861703.
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    82. Protein kinase C pharmacology: refining the toolbox. Biochem J. 2013 Jun 01; 452(2):195-209. Wu-Zhang AX, Newton AC. PMID: 23662807; PMCID: PMC4079666.
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    83. Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα. J Biol Chem. 2013 Jun 07; 288(23):16905-16915. Scott AM, Antal CE, Newton AC. PMID: 23589289; PMCID: PMC3675623.
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    84. Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging. J Biol Chem. 2012 Nov 02; 287(45):37891-906. Wu-Zhang AX, Murphy AN, Bachman M, Newton AC. PMID: 22988234; PMCID: PMC3488061.
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    85. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chem Biol. 2012 Aug 24; 19(8):994-1000. de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG. PMID: 22921066; PMCID: PMC4079670.
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    86. Shedding light on local kinase activation. BMC Biol. 2012 Jul 17; 10:61. Scott JD, Newton AC. PMID: 22805055; PMCID: PMC3398854.
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    87. Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J. 2013 Jan; 280(2):572-83. O'Neill AK, Niederst MJ, Newton AC. PMID: 22340730; PMCID: PMC3770140.
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    88. Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory. J Biol Chem. 2012 Apr 13; 287(16):12879-85. Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC. PMID: 22378786; PMCID: PMC3339930.
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    89. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. PMID: 22318721; PMCID: PMC3339987.
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    90. Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia. 2012 Jul; 26(7):1689-92. O'Hayre M, Niederst M, Fecteau JF, Nguyen VM, Kipps TJ, Messmer D, Newton AC, Handel TM. PMID: 22237780; PMCID: PMC3395972.
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    91. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. J Biol Chem. 2012 Feb 03; 287(6):3610-6. Warfel NA, Newton AC. PMID: 22144674; PMCID: PMC3281723.
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    92. Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011 Dec 16; 286(50):43559-68. O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton AC. PMID: 22027822; PMCID: PMC3234831.
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    93. Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. J Biol Chem. 2011 Nov 11; 286(45):39122-9. Warfel NA, Niederst M, Newton AC. PMID: 21908613; PMCID: PMC3234737.
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    94. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 2011 Aug 16; 20(2):173-86. Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, Carver BS, Trotman LC. PMID: 21840483; PMCID: PMC3176728.
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    95. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. J Biol Chem. 2011 Sep 23; 286(38):33390-400. Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. PMID: 21795686; PMCID: PMC3190922.
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    96. Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem. 2011 Aug 19; 286(33):28922-28930. Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC. PMID: 21715334; PMCID: PMC3190699.
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    97. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem. 2011 Jul 01; 286(26):23552-8. Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. PMID: 21561857; PMCID: PMC3123118.
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    98. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol. 2011 May 15; 186(10):5533-7. Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK. PMID: 21498666; PMCID: PMC4015973.
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    99. Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem. 2011 Jun 03; 286(22):19777-88. Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. PMID: 21454620; PMCID: PMC3103356.
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    100. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci. 2011 Feb 09; 31(6):2113-24. Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. PMID: 21307248; PMCID: PMC3097059.
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    101. Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. Methods Mol Biol. 2011; 756:295-310. Gallegos LL, Newton AC. PMID: 21870234; PMCID: PMC4048020.
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    102. Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. J Biol Chem. 2010 Dec 31; 285(53):41896-910. Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton AC. PMID: 20959447; PMCID: PMC3009917.
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    103. Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem. 2010 Oct 14; 53(19):6899-911. Sierecki E, Sinko W, McCammon JA, Newton AC. PMID: 20836557; PMCID: PMC2951065.
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    104. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PMID: 20576936; PMCID: PMC2957297.
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    105. Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes. J Biol Chem. 2010 Jul 23; 285(30):22748-52. Kunkel MT, Newton AC. PMID: 20519514; PMCID: PMC2906264.
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    106. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010 Feb 26; 37(4):541-50. Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. PMID: 20188672; PMCID: PMC3014287.
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    107. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1642-7. Masubuchi S, Gao T, O'Neill A, Eckel-Mahan K, Newton AC, Sassone-Corsi P. PMID: 20080691; PMCID: PMC2824391.
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    108. Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters. Curr Protoc Chem Biol. 2009 Dec 01; 1(1):17-18. Kunkel MT, Newton AC. PMID: 21804950; PMCID: PMC3146362.
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    109. Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E395-402. Newton AC. PMID: 19934406; PMCID: PMC2838521.
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    110. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. J Biol Chem. 2009 Sep 04; 284(36):24653-61. Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC. PMID: 19581308; PMCID: PMC2782054.
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    111. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. J Biol Chem. 2009 May 29; 284(22):15215-23. Brognard J, Niederst M, Reyes G, Warfel N, Newton AC. PMID: 19324870; PMCID: PMC2685702.
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    112. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem. 2009 Feb 20; 284(8):4921-35. Gould CM, Kannan N, Taylor SS, Newton AC. PMID: 19091746; PMCID: PMC2643500.
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    113. Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. IUBMB Life. 2008 Dec; 60(12):782-9. Gallegos LL, Newton AC. PMID: 18720411; PMCID: PMC2718795.
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    114. Lipid activation of protein kinases. J Lipid Res. 2009 Apr; 50 Suppl:S266-71. Newton AC. PMID: 19033211; PMCID: PMC2674703.
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    115. Protein kinase C. IUBMB Life. 2008 Nov; 60(11):765-8. Newton AC. PMID: 18683875.
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    116. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell. 2008 Oct 24; 32(2):169-79. Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD. PMID: 18951085; PMCID: PMC3169907.
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    117. The life and death of protein kinase C. Curr Drug Targets. 2008 Aug; 9(8):614-25. Gould CM, Newton AC. PMID: 18691009; PMCID: PMC5783564.
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    118. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23; 27(14):1932-43. Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. PMID: 18566586; PMCID: PMC2486276.
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    119. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab. 2008 Aug; 19(6):223-30. Brognard J, Newton AC. PMID: 18511290; PMCID: PMC2963565.
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    120. Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy. J Biol Chem. 2008 Mar 21; 283(12):7885-93. Dries DR, Newton AC. PMID: 18187412.
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    121. The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem. 2008 Mar 07; 283(10):6300-11. Gao T, Brognard J, Newton AC. PMID: 18162466.
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    122. Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007). IUBMB Life. 2007 Dec; 59(12):741-3. Newton AC, Mochly-Rosen D. PMID: 18085473.
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    123. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem. 2007 Nov 16; 282(46):33776-33787. Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. PMID: 17893151.
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    124. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007 Mar 23; 25(6):917-31. Brognard J, Sierecki E, Gao T, Newton AC. PMID: 17386267.
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    125. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem. 2007 Mar 02; 282(9):6733-42. Kunkel MT, Toker A, Tsien RY, Newton AC. PMID: 17189263; PMCID: PMC2921767.
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    126. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J Biol Chem. 2007 Jan 12; 282(2):826-30. Dries DR, Gallegos LL, Newton AC. PMID: 17071619.
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    127. Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70. J Biol Chem. 2006 Oct 27; 281(43):32461-8. Gao T, Newton AC. PMID: 16954220.
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    128. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem. 2006 Oct 13; 281(41):30947-56. Gallegos LL, Kunkel MT, Newton AC. PMID: 16901905.
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    129. Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem. 2006 Jan 20; 281(3):1660-9. Giorgione JR, Lin JH, McCammon JA, Newton AC. PMID: 16293612; PMCID: PMC2913972.
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    130. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005 Apr 01; 18(1):13-24. Gao T, Furnari F, Newton AC. PMID: 15808505.
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    131. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem. 2005 Feb 18; 280(7):5581-7. Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. PMID: 15583002; PMCID: PMC2913970.
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    132. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2004 Sep 03; 279(36):37518-27. King CC, Newton AC. PMID: 15210700.
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    133. Diacylglycerol's affair with protein kinase C turns 25. Trends Pharmacol Sci. 2004 Apr; 25(4):175-7. Newton AC. PMID: 15116719.
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    134. Pathway illuminated: visualizing protein kinase C signaling. IUBMB Life. 2003 Dec; 55(12):653-60. Violin JD, Newton AC. PMID: 14769001.
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    135. Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. J Biol Chem. 2004 Feb 06; 279(6):4829-39. Chen D, Purohit A, Halilovic E, Doxsey SJ, Newton AC. PMID: 14594954.
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    136. Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. Biochemistry. 2003 Sep 30; 42(38):11194-202. Giorgione J, Hysell M, Harvey DF, Newton AC. PMID: 14503869.
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    137. Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J. 2003 Sep 01; 374(Pt 2):537-43. Adams RA, Liu X, Williams DS, Newton AC. PMID: 12809555; PMCID: PMC1223618.
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    138. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9470-5. Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T. PMID: 12881490; PMCID: PMC170942.
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    139. Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions. J Org Chem. 2003 Jun 27; 68(13):5028-36. Bertolini TM, Giorgione J, Harvey DF, Newton AC. PMID: 12816455.
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    140. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol. 2003 Jun 09; 161(5):899-909. Violin JD, Zhang J, Tsien RY, Newton AC. PMID: 12782683; PMCID: PMC2172956.
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    141. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J. 2003 Mar 01; 370(Pt 2):361-71. Newton AC. PMID: 12495431; PMCID: PMC1223206.
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    142. Measuring the interaction of protein kinase C with membranes: an introduction. Methods Mol Biol. 2003; 233:89-92. Newton AC. PMID: 12840500.
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    143. Measuring the binding of protein kinase C to sucrose-loaded vesicles. Methods Mol Biol. 2003; 233:105-13. Giorgione J, Newton AC. PMID: 12840502.
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    144. Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C. Methods Mol Biol. 2003; 233:115-28. Nalefski EA, Newton AC. PMID: 12840503.
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    145. The ins and outs of protein kinase C. Methods Mol Biol. 2003; 233:3-7. Newton AC. PMID: 12840493.
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    146. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem. 2002 Aug 30; 277(35):31585-92. Gao T, Newton AC. PMID: 12080070.
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    147. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science. 2002 May 03; 296(5569):913-6. Zacharias DA, Violin JD, Newton AC, Tsien RY. PMID: 11988576.
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    148. Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J. 2002 May 01; 363(Pt 3):537-45. Cenni V, Döppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A. PMID: 11964154; PMCID: PMC1222506.
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    149. Analyzing protein kinase C activation. Methods Enzymol. 2002; 345:499-506. Newton AC. PMID: 11665632.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    150. Membrane binding kinetics of protein kinase C betaII mediated by the C2 domain. Biochemistry. 2001 Nov 06; 40(44):13216-29. Nalefski EA, Newton AC. PMID: 11683630.
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    151. PKA, PKC, and AKAP localization in and around the neuromuscular junction. BMC Neurosci. 2001; 2:17. Perkins GA, Wang L, Huang LJ, Humphries K, Yao VJ, Martone M, Deerinck TJ, Barraclough DM, Violin JD, Smith D, Newton A, Scott JD, Taylor SS, Ellisman MH. PMID: 11716788; PMCID: PMC59892.
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    152. The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. J Biol Chem. 2001 Nov 30; 276(48):45289-97. Sonnenburg ED, Gao T, Newton AC. PMID: 11579098.
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    153. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev. 2001 Aug; 101(8):2353-64. Newton AC. PMID: 11749377.
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    154. The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA. J Biol Chem. 2001 Sep 21; 276(38):35794-801. Newton A, Mackay J, Crossley M. PMID: 11445591.
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    155. Complete genome sequence of Caulobacter crescentus. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):4136-41. Nierman WC, Feldblyum TV, Laub MT, Paulsen IT, Nelson KE, Eisen JA, Heidelberg JF, Alley MR, Ohta N, Maddock JR, Potocka I, Nelson WC, Newton A, Stephens C, Phadke ND, Ely B, DeBoy RT, Dodson RJ, Durkin AS, Gwinn ML, Haft DH, Kolonay JF, Smit J, Craven MB, Khouri H, Shetty J, Berry K, Utterback T, Tran K, Wolf A, Vamathevan J, Ermolaeva M, White O, Salzberg SL, Venter JC, Shapiro L, Fraser CM, Eisen J. PMID: 11259647; PMCID: PMC31192.
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    156. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. J Biol Chem. 2001 Jun 01; 276(22):19588-96. Gao T, Toker A, Newton AC. PMID: 11376011.
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    157. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem. 2000 Dec 29; 275(52):41201-9. King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM. PMID: 10995762.
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    158. Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions. Structure. 2000 Nov 15; 8(11):1157-66. Liew CK, Kowalski K, Fox AH, Newton A, Sharpe BK, Crossley M, Mackay JP. PMID: 11080638.
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    159. Cellular signaling: pivoting around PDK-1. Cell. 2000 Oct 13; 103(2):185-8. Toker A, Newton AC. PMID: 11057891.
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    160. The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain. Biochemistry. 2000 Sep 19; 39(37):11360-9. Johnson JE, Giorgione J, Newton AC. PMID: 10985781.
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    161. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol. 2000 Sep; 279(3):L429-38. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. PMID: 10956616.
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    162. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. J Biol Chem. 2000 Jun 16; 275(24):18108-13. King CC, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch GM. PMID: 10748151.
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    163. Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol. J Biol Chem. 2000 Apr 07; 275(14):10697-701. Dutil EM, Newton AC. PMID: 10744767.
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    164. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 2000 Apr; 85(3):395-404. Granados-Soto V, Kalcheva I, Hua XY, Newton A, Yaksh TL. PMID: 10781912.
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    165. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem. 2000 Mar 24; 275(12):8271-4. Toker A, Newton AC. PMID: 10722653.
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    166. A novel bacterial tyrosine kinase essential for cell division and differentiation. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13068-73. Wu J, Ohta N, Zhao JL, Newton A. PMID: 10557274; PMCID: PMC23901.
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    167. Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction. Biochem J. 1999 Oct 15; 343 Pt 2:443-52. Faux MC, Rollins EN, Edwards AS, Langeberg LK, Newton AC, Scott JD. PMID: 10510312; PMCID: PMC1220573.
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    168. The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Curr Biol. 1999 Jul 15; 9(14):728-37. Behn-Krappa A, Newton AC. PMID: 10421574.
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    169. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. J Biol Chem. 1999 Mar 05; 274(10):6461-8. Edwards AS, Faux MC, Scott JD, Newton AC. PMID: 10037738.
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    170. Mechanism of the apparent cooperativity in the interaction of protein kinase C with phosphatidylserine. Biochemistry. 1998 Dec 08; 37(49):17271-9. Mosior M, Newton AC. PMID: 9860841.
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    171. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol. 1998 Dec 17-31; 8(25):1366-75. Dutil EM, Toker A, Newton AC. PMID: 9889098.
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    172. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol. 1998 Sep 24; 8(19):1069-77. Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A. PMID: 9768361.
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    173. Lipid structure and not membrane structure is the major determinant in the regulation of protein kinase C by phosphatidylserine. Biochemistry. 1998 Sep 01; 37(35):12020-5. Johnson JE, Zimmerman ML, Daleke DL, Newton AC. PMID: 9724512.
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    174. Protected-site phosphorylation of protein kinase C in hippocampal long-term potentiation. J Neurochem. 1998 Sep; 71(3):1075-85. Sweatt JD, Atkins CM, Johnson J, English JD, Roberson ED, Chen SJ, Newton A, Klann E. PMID: 9721732.
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    175. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochim Biophys Acta. 1998 Aug 21; 1376(2):155-72. Newton AC, Johnson JE. PMID: 9748550.
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    176. Regulation of the phosphorylation state of rhodopsin by dopamine. J Biol Chem. 1998 Mar 27; 273(13):7181-4. Udovichenko IP, Newton AC, Williams DS. PMID: 9516406.
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    177. An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1443-8. Wu J, Ohta N, Newton A. PMID: 9465034; PMCID: PMC19037.
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    178. Regulation of protein kinase C betaII by its C2 domain. Biochemistry. 1997 Dec 16; 36(50):15615-23. Edwards AS, Newton AC. PMID: 9398289.
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    179. A putative phosphatidylserine binding motif is not involved in the lipid regulation of protein kinase C. J Biol Chem. 1997 Dec 05; 272(49):30787-92. Johnson JE, Edwards AS, Newton AC. PMID: 9388219.
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    180. Requirement of topoisomerase IV parC and parE genes for cell cycle progression and developmental regulation in Caulobacter crescentus. Mol Microbiol. 1997 Dec; 26(5):897-910. Ward D, Newton A. PMID: 9426128.
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    181. Ca2+ differentially regulates conventional protein kinase Cs' membrane interaction and activation. J Biol Chem. 1997 Oct 10; 272(41):25959-67. Keranen LM, Newton AC. PMID: 9325330.
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    182. Characterization of protein kinase C in photoreceptor outer segments. J Neurochem. 1997 Oct; 69(4):1693-702. Williams DS, Liu X, Schlamp CL, Ondek B, Jaken S, Newton AC. PMID: 9326298.
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    183. Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C. J Biol Chem. 1997 Jul 18; 272(29):18382-90. Edwards AS, Newton AC. PMID: 9218480.
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    184. Identification of protein kinase C phosphorylation sites on bovine rhodopsin. J Biol Chem. 1997 Apr 18; 272(16):10341-4. Greene NM, Williams DS, Newton AC. PMID: 9099669.
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    185. Regulation of protein kinase C. Curr Opin Cell Biol. 1997 Apr; 9(2):161-7. Newton AC. PMID: 9069266.
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    186. Identification, characterization, and chromosomal organization of cell division cycle genes in Caulobacter crescentus. J Bacteriol. 1997 Apr; 179(7):2169-80. Ohta N, Ninfa AJ, Allaire A, Kulick L, Newton A. PMID: 9079901; PMCID: PMC178952.
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    187. Contribution of protein kinase C to the phosphorylation of rhodopsin in intact retinas. J Biol Chem. 1997 Mar 21; 272(12):7952-9. Udovichenko IP, Newton AC, Williams DS. PMID: 9065465.
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    188. Taxonomy and function of C1 protein kinase C homology domains. Protein Sci. 1997 Feb; 6(2):477-80. Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y. PMID: 9041654; PMCID: PMC2143645.
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    189. Inhibition of the insulin receptor tyrosine kinase by phosphatidic acid. J Cell Biochem. 1996 Sep 15; 62(4):516-28. Arnold RS, Newton AC. PMID: 8891897.
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    190. Protein kinase C: ports of anchor in the cell. Curr Biol. 1996 Jul 01; 6(7):806-9. Newton AC. PMID: 8805297.
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    191. Isolation, identification, and transcriptional specificity of the heat shock sigma factor sigma32 from Caulobacter crescentus. J Bacteriol. 1996 Apr; 178(7):2094-101. Wu J, Newton A. PMID: 8606189; PMCID: PMC177910.
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    192. Diacylglycerol directly stimulates the insulin receptor tyrosine kinase. FEBS Lett. 1996 Feb 12; 380(1-2):58-62. Arnold RS, Newton AC. PMID: 8603747.
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    193. Calcium-independent binding to interfacial phorbol esters causes protein kinase C to associate with membranes in the absence of acidic lipids. Biochemistry. 1996 Feb 06; 35(5):1612-23. Mosior M, Newton AC. PMID: 8634293.
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    194. Protein kinase C: structure, function, and regulation. J Biol Chem. 1995 Dec 01; 270(48):28495-8. Newton AC. PMID: 7499357.
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    195. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol. 1995 Dec 01; 5(12):1394-1403. Keranen LM, Dutil EM, Newton AC. PMID: 8749392.
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    196. Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov; 177(21):6223-9. Hecht GB, Newton A. PMID: 7592388; PMCID: PMC177463.
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    197. Mechanism of interaction of protein kinase C with phorbol esters. Reversibility and nature of membrane association. J Biol Chem. 1995 Oct 27; 270(43):25526-33. Mosior M, Newton AC. PMID: 7592722.
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    198. Protein kinase C. Seeing two domains. Curr Biol. 1995 Sep 01; 5(9):973-6. Newton AC. PMID: 8542286.
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    199. An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus. EMBO J. 1995 Aug 15; 14(16):3915-24. Hecht GB, Lane T, Ohta N, Sommer JM, Newton A. PMID: 7664732; PMCID: PMC394470.
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    200. Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C. J Biol Chem. 1995 Mar 24; 270(12):6710-7. Greene NM, Williams DS, Newton AC. PMID: 7896814.
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    201. Isozyme-specific inhibition of protein kinase C by RNA aptamers. J Biol Chem. 1994 Dec 23; 269(51):32051-4. Conrad R, Keranen LM, Ellington AD, Newton AC. PMID: 7528207.
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    202. In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation. J Biol Chem. 1994 Nov 25; 269(47):29359-62. Dutil EM, Keranen LM, DePaoli-Roach AA, Newton AC. PMID: 7961910.
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    203. Requirement for negative charge on "activation loop" of protein kinase C. J Biol Chem. 1994 Nov 04; 269(44):27715-8. Orr JW, Newton AC. PMID: 7961692.
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    204. Information essential for cell-cycle-dependent secretion of the 591-residue Caulobacter hook protein is confined to a 21-amino-acid sequence near the N-terminus. Mol Microbiol. 1994 Oct; 14(1):73-85. Kornacker MG, Newton A. PMID: 7830563.
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    205. Protein kinase C association with the retinal cytoskeleton and phosphorylation of vimentin. Exp Eye Res. 1994 Jun; 58(6):747-59. Williams DS, Park S, Schlamp CL, Newton AC. PMID: 7925714.
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    206. Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes. Biochemistry. 1994 May 31; 33(21):6651-8. Newton AC, Keranen LM. PMID: 8204602.
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    207. Intrapeptide regulation of protein kinase C. J Biol Chem. 1994 Mar 18; 269(11):8383-7. Orr JW, Newton AC. PMID: 8132562.
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    208. Protein kinase C as a measure of transbilayer phosphatidylserine asymmetry. Anal Biochem. 1994 Feb 15; 217(1):33-40. Daleke DL, Huestis WH, Newton AC. PMID: 8203737.
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    209. Gene expression of the neuropeptide-processing enzyme carboxypeptidase E in rat photoreceptor cells. J Neurochem. 1993 Nov; 61(5):1891-900. Nickells RW, Schlamp CL, Newton AC, Williams DS. PMID: 7693871.
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    210. Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors. J Biol Chem. 1993 Aug 25; 268(24):18181-6. Newton AC, Williams DS. PMID: 8349693.
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    211. Does protein kinase C play a role in rhodopsin desensitization? Trends Biochem Sci. 1993 Aug; 18(8):275-7. Newton AC, Williams DS. PMID: 8236436.
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    212. Interaction of proteins with lipid headgroups: lessons from protein kinase C. Annu Rev Biophys Biomol Struct. 1993; 22:1-25. Newton AC. PMID: 8347986.
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    213. A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10297-301. Ohta N, Lane T, Ninfa EG, Sommer JM, Newton A. PMID: 1438215; PMCID: PMC50325.
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    214. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. J Biol Chem. 1992 Aug 05; 267(22):15263-6. Orr JW, Keranen LM, Newton AC. PMID: 1639770.
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    215. Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding. Biochemistry. 1992 May 19; 31(19):4661-7. Orr JW, Newton AC. PMID: 1581316.
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    216. Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation. Biochemistry. 1992 May 19; 31(19):4667-73. Orr JW, Newton AC. PMID: 1581317.
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    217. Cell cycle regulation in bacteria. Curr Opin Cell Biol. 1992 Apr; 4(2):180-5. Newton A, Ohta N. PMID: 1599688.
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    218. Involvement of protein kinase C in the phosphorylation of rhodopsin. J Biol Chem. 1991 Sep 25; 266(27):17725-8. Newton AC, Williams DS. PMID: 1917916.
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    219. Inhibition of the insulin receptor tyrosine kinase by sphingosine. Biochemistry. 1991 Aug 06; 30(31):7747-54. Arnold RS, Newton AC. PMID: 1651108.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    220. Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation. Biochemistry. 1990 Jul 17; 29(28):6656-61. Newton AC, Koshland DE. PMID: 2397206.
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    221. High cooperativity, specificity, and multiplicity in the protein kinase C-lipid interaction. J Biol Chem. 1989 Sep 05; 264(25):14909-15. Newton AC, Koshland DE. PMID: 2768246.
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    222. Cyclitic glaucoma. Aust N Z J Ophthalmol. 1989 May; 17(2):157-64. Brooks AM, Grant G, Young T, Newton A, Gillies WE. PMID: 2757830.
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    223. Lymphoma-vesicle interactions: vesicle adsorption, membrane fragmentation, and intermembrane protein transfer. Biochemistry. 1988 Jun 28; 27(13):4645-55. Newton AC, Huestis WH. PMID: 3167007.
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    224. Vesicle-to-cell protein transfer: insertion of band 3, the erythrocyte anion transporter, into lymphoid cells. Biochemistry. 1988 Jun 28; 27(13):4655-9. Newton AC, Huestis WH. PMID: 3167008.
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    225. Protein kinase C autophosphorylates by an intrapeptide reaction. J Biol Chem. 1987 Jul 25; 262(21):10185-8. Newton AC, Koshland DE. PMID: 3611058.
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    226. Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry. 1987 May 19; 26(10):2886-93. Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE, Cole RD. PMID: 3111527.
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    227. Efflux of dipicolinic acid from human erythrocytes, sealed membrane fragments, and band 3-liposome complexes: a fluorescence probe for the erythrocyte anion transporter. Anal Biochem. 1986 Jul; 156(1):56-60. Newton AC, Huestis WH. PMID: 3740418.
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    228. Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells. Biochemistry. 1983 Dec 20; 22(26):6110-7. Newton AC, Cook SL, Huestis WH. PMID: 6661430.
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    229. Regulation of periodic protein synthesis in the cell cycle: control of initiation and termination of flagellar gene expression. Cell. 1981 Apr; 24(1):49-57. Sheffery M, Newton A. PMID: 7237543.
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    230. Regulation of flagellin synthesis in the cell cycle of caulobacter: dependence on DNA replication. Cell. 1977 Oct; 12(2):393-400. Osley MA, Sheffery M, Newton A. PMID: 912749.
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