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Randolph Hampton

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0347
La Jolla CA 92093
Phone858-822-0511
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    Collapse Research 
    Collapse Research Activities and Funding
    FASEB SRC on Ubiquitin and Cellular Regulation
    NIH/NCI R13CA168247Jul 27, 2012 - May 31, 2013
    Role: Principal Investigator
    Ubr1: A Protein Quality Control E3 Ubiquitin Ligase
    NIH/NIGMS R01GM092748Sep 30, 2011 - May 31, 2015
    Role: Principal Investigator
    Protein degradation and cholesterol regulation
    NIH/NIDDK R37DK051996Jan 1, 1997 - Jan 31, 2021
    Role: Principal Investigator
    Protein degradation and cholesterol regulation
    NIH/NIDDK R01DK051996Jan 1, 1997 - Jan 31, 2012
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Cell and Molecular Genetics Training Program
    NIH/NIGMS T32GM007240Jul 1, 1975 - Jun 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wangeline MA, Hampton RY. "Mallostery"-ligand-dependent protein misfolding enables physiological regulation by ERAD. J Biol Chem. 2018 Jul 17. PMID: 30018140.
      View in: PubMed
    2. Neal S, Jaeger PA, Duttke SH, Benner C, Glass CK, Ideker T, Hampton RY. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Mol Cell. 2018 Mar 01; 69(5):915. PMID: 29499140.
      View in: PubMed
    3. Jaeger PA, Ornelas L, McElfresh C, Wong LR, Hampton RY, Ideker T. Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping. Mol Cell. 2018 Jan 18; 69(2):321-333.e3. PMID: 29351850.
      View in: PubMed
    4. Neal S, Jaeger PA, Duttke SH, Benner C, K Glass C, Ideker T, Hampton RY. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Mol Cell. 2018 Jan 18; 69(2):306-320.e4. PMID: 29351849.
      View in: PubMed
    5. Wangeline MA, Vashistha N, Hampton RY. Proteostatic Tactics in the Strategy of Sterol Regulation. Annu Rev Cell Dev Biol. 2017 Oct 06; 33:467-489. PMID: 28992438.
      View in: PubMed
    6. Hampton RY, Dargemont C. New developments for protein quality control. Science. 2017 08 04; 357(6350):450-451. PMID: 28774913.
      View in: PubMed
    7. Neal S, Mak R, Bennett EJ, Hampton R. A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates. J Biol Chem. 2017 02 24; 292(8):3112-3128. PMID: 28077573.
      View in: PubMed
    8. Vashistha N, Neal SE, Singh A, Carroll SM, Hampton RY. Direct and essential function for Hrd3 in ER-associated degradation. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):5934-9. PMID: 27170191; PMCID: PMC4889393 [Available on 11/24/16].
    9. Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Mol Cell. 2015 Jul 02; 59(1):35-49. PMID: 26051182; PMCID: PMC4491043.
    10. Theesfeld CL, Hampton RY. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. J Biol Chem. 2013 Mar 22; 288(12):8519-30. PMID: 23306196; PMCID: PMC3605666.
    11. Hampton RY, Sommer T. Finding the will and the way of ERAD substrate retrotranslocation. Curr Opin Cell Biol. 2012 Aug; 24(4):460-6. PMID: 22854296.
      View in: PubMed
    12. Li S, Spooner RA, Hampton RY, Lord JM, Roberts LM. Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p. PLoS One. 2012; 7(7):e41119. PMID: 22829918.
      View in: PubMed
    13. Theesfeld CL, Pourmand D, Davis T, Garza RM, Hampton RY. The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. J Biol Chem. 2011 Jul 29; 286(30):26298-307. PMID: 21628456; PMCID: PMC3143592.
    14. Hampton RY. San1-mediated quality control: substrate recognition "sans" chaperones. Mol Cell. 2011 Jan 07; 41(1):2-3. PMID: 21211716.
      View in: PubMed
    15. Heck JW, Cheung SK, Hampton RY. Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1106-11. PMID: 20080635; PMCID: PMC2824284.
    16. Garza RM, Tran PN, Hampton RY. Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. J Biol Chem. 2009 Dec 18; 284(51):35368-80. PMID: 19776008; PMCID: PMC2790966.
    17. Carroll SM, Hampton RY. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. J Biol Chem. 2010 Feb 19; 285(8):5146-56. PMID: 19940128; PMCID: PMC2820741.
    18. Sato BK, Schulz D, Do PH, Hampton RY. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell. 2009 Apr 24; 34(2):212-22. PMID: 19394298; PMCID: PMC2710143.
    19. Hampton RY, Garza RM. Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. Chem Rev. 2009 Apr; 109(4):1561-74. PMID: 19243134.
      View in: PubMed
    20. Garza RM, Sato BK, Hampton RY. In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. J Biol Chem. 2009 May 29; 284(22):14710-22. PMID: 19324879; PMCID: PMC2685653.
    21. Hampton RY. A cholesterol toggle switch. Cell Metab. 2008 Dec; 8(6):451-3. PMID: 19041760.
      View in: PubMed
    22. Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY. Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell. 2008 Oct; 19(10):4506-20. PMID: 18667535; PMCID: PMC2555956.
    23. Bazirgan OA, Hampton RY. Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. J Biol Chem. 2008 May 09; 283(19):12797-810. PMID: 18321851; PMCID: PMC2442330.
    24. Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem. 2007 Nov 16; 282(46):33776-87. PMID: 17893151.
      View in: PubMed
    25. Bazirgan OA, Garza RM, Hampton RY. Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase. J Biol Chem. 2006 Dec 22; 281(51):38989-9001. PMID: 17035235.
      View in: PubMed
    26. Sato BK, Hampton RY. Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast. 2006 Oct-Nov; 23(14-15):1053-64. PMID: 17083136.
      View in: PubMed
    27. Flury I, Garza R, Shearer A, Rosen J, Cronin S, Hampton RY. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. EMBO J. 2005 Nov 16; 24(22):3917-26. PMID: 16270032; PMCID: PMC1283954.
    28. Federovitch CM, Ron D, Hampton RY. The dynamic ER: experimental approaches and current questions. Curr Opin Cell Biol. 2005 Aug; 17(4):409-14. PMID: 15975777.
      View in: PubMed
    29. Garza RM, Hampton RY. Cell biology: sterol sensor comes up for air. Nature. 2005 May 05; 435(7038):37-8. PMID: 15875007.
      View in: PubMed
    30. Bazirgan OA, Hampton RY. Cdc48-Ufd2-Rad23: the road less ubiquitinated? Nat Cell Biol. 2005 Mar; 7(3):207-9. PMID: 15738968.
      View in: PubMed
    31. Shearer AG, Hampton RY. Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. EMBO J. 2005 Jan 12; 24(1):149-59. PMID: 15635451; PMCID: PMC544911.
    32. Hampton RY. Fusion-based strategies to identify genes involved in degradation of a specific substrate. Methods Enzymol. 2005; 399:310-23. PMID: 16338365.
      View in: PubMed
    33. Ron D, Hampton RY. Membrane biogenesis and the unfolded protein response. J Cell Biol. 2004 Oct 11; 167(1):23-5. PMID: 15479733; PMCID: PMC2172515.
    34. Shearer AG, Hampton RY. Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem. 2004 Jan 02; 279(1):188-96. PMID: 14570925.
      View in: PubMed
    35. Hampton RY. IRE1: a role in UPREgulation of ER degradation. Dev Cell. 2003 Feb; 4(2):144-6. PMID: 12586055.
      View in: PubMed
    36. Hampton RY. ER-associated degradation in protein quality control and cellular regulation. Curr Opin Cell Biol. 2002 Aug; 14(4):476-82. PMID: 12383799.
      View in: PubMed
    37. Cronin SR, Rao R, Hampton RY. Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol. 2002 Jun 10; 157(6):1017-28. PMID: 12058017; PMCID: PMC2174042.
    38. Bays NW, Hampton RY. Cdc48-Ufd1-Npl4: stuck in the middle with Ub. Curr Biol. 2002 May 14; 12(10):R366-71. PMID: 12015140.
      View in: PubMed
    39. Hampton RY. Proteolysis and sterol regulation. Annu Rev Cell Dev Biol. 2002; 18:345-78. PMID: 12142284.
      View in: PubMed
    40. Hampton RY. Cholesterol homeostasis: ESCAPe from the ER. Curr Biol. 2000 Apr 20; 10(8):R298-301. PMID: 10801406.
      View in: PubMed