Roberto Malinow

Title(s)Senate Emeritus, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    SYNPLA: A scaleable method for monitoring circuit-specific learning-induced changes in synaptic strength
    NIH U01MH109113Sep 25, 2015 - Jun 30, 2019
    Role: Principal Investigator
    A Synaptic Locus Controlling Behavioral Depression
    NIH R01MH091119Jul 1, 2010 - Feb 28, 2021
    Role: Principal Investigator
    Novel roles by glutamatergic receptors in the synaptic effects of beta amyloid
    NIH R01AG032132Apr 1, 1995 - Jun 30, 2018
    Role: Principal Investigator
    Protein Kinases in Synaptic Plasticity
    NIH R01NS032827Apr 1, 1995 - Feb 29, 2008
    Role: Principal Investigator
    Mechanisms of LTP:AMPA receptor dynamics
    NIH R01MH049159May 1, 1992 - Jan 31, 2021
    Role: Principal Investigator
    Mechanisms of synaptic LTP
    NIH R37MH049159May 1, 1992 - Apr 30, 2010
    Role: Principal Investigator
    MECHANISMS OF LONG TERM SYNAPTIC POTENTIATION
    NIH R29MH049159May 1, 1992 - Apr 30, 1997
    Role: Principal Investigator
    MODULATION OF RHYTHMIC BURSTING IN MOTORNEURONS
    NIH F32NS007752Jul 22, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Detecting unitary synaptic events with machine learning. Proc Natl Acad Sci U S A. 2024 Feb 06; 121(6):e2315804121. Wang NS, Marino M, Malinow R. PMID: 38294937; PMCID: PMC10861888.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. A Machine Learning Method to Identify Genetic Variants Potentially Associated With Alzheimer's Disease. Front Genet. 2021; 12:647436. Monk B, Rajkovic A, Petrus S, Rajkovic A, Gaasterland T, Malinow R. PMID: 34194466; PMCID: PMC8238203.
      View in: PubMed   Mentions: 7  
    3. PSD-95 protects synapses from β-amyloid. Cell Rep. 2021 06 01; 35(9):109194. Dore K, Carrico Z, Alfonso S, Marino M, Koymans K, Kessels HW, Malinow R. PMID: 34077732; PMCID: PMC8237704.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    4. Reply to Hashimoto: Ketamine is not an opioid but requires opioid system for antidepressant actions. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11202-11203. Malinow R, Klein ME. PMID: 32430327; PMCID: PMC7260948.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity. Neuroscience. 2021 02 21; 456:43-49. Dore K, Malinow R. PMID: 32114099; PMCID: PMC7483149.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    6. SYNPLA, a method to identify synapses displaying plasticity after learning. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):3214-3219. Dore K, Pao Y, Soria Lopez J, Aronson S, Zhan H, Ghosh S, Merrill S, Zador AM, Malinow R, Kebschull JM. PMID: 31974314; PMCID: PMC7022215.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2656-2662. Klein ME, Chandra J, Sheriff S, Malinow R. PMID: 31941713; PMCID: PMC7007545.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    8. Stress transforms lateral habenula reward responses into punishment signals. Proc Natl Acad Sci U S A. 2019 06 18; 116(25):12488-12493. Shabel SJ, Wang C, Monk B, Aronson S, Malinow R. PMID: 31152135; PMCID: PMC6589650.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    9. A neural pathway controlling motivation to exert effort. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5792-5797. Proulx CD, Aronson S, Milivojevic D, Molina C, Loi A, Monk B, Shabel SJ, Malinow R. PMID: 29752382; PMCID: PMC5984527.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    10. A fluorescence assay for detecting amyloid-β using the cytomegalovirus enhancer/promoter. J Biol Methods. 2017; 4(3). Carrico ZM, Le G, Malinow R. PMID: 29457040; PMCID: PMC5813829.
      View in: PubMed   Mentions: 2  
    11. The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging. Front Synaptic Neurosci. 2016; 8:20. Dore K, Aow J, Malinow R. PMID: 27516738; PMCID: PMC4963461.
      View in: PubMed   Mentions: 35  
    12. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016 05 10; 9(427):ra47. Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. PMID: 27165780; PMCID: PMC5154619.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    13. Depression: Ketamine steps out of the darkness. Nature. 2016 05 26; 533(7604):477-8. Malinow R. PMID: 27144350; PMCID: PMC5102012.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    14. Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice. Biol Psychiatry. 2016 12 01; 80(11):827-835. Landgraf D, Long JE, Proulx CD, Barandas R, Malinow R, Welsh DK. PMID: 27113500; PMCID: PMC5102810.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    15. Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14705-10. Dore K, Aow J, Malinow R. PMID: 26553997; PMCID: PMC4664357.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    16. Conformational signaling required for synaptic plasticity by the NMDA receptor complex. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14711-6. Aow J, Dore K, Malinow R. PMID: 26553983; PMCID: PMC4664326.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    17. Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment. Science. 2014 Sep 19; 345(6203):1494-8. Shabel SJ, Proulx CD, Piriz J, Malinow R. PMID: 25237099; PMCID: PMC4305433.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    18. Reward processing by the lateral habenula in normal and depressive behaviors. Nat Neurosci. 2014 Sep; 17(9):1146-52. Proulx CD, Hikosaka O, Malinow R. PMID: 25157511; PMCID: PMC4305435.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimals
    19. Engineering a memory with LTD and LTP. Nature. 2014 Jul 17; 511(7509):348-52. Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R. PMID: 24896183; PMCID: PMC4210354.
      View in: PubMed   Mentions: 399     Fields:    Translation:AnimalsCells
    20. Near-infrared-induced heating of confined water in polymeric particles for efficient payload release. ACS Nano. 2014 May 27; 8(5):4815-26. Viger ML, Sheng W, Doré K, Alhasan AH, Carling CJ, Lux J, de Gracia Lux C, Grossman M, Malinow R, Almutairi A. PMID: 24717072; PMCID: PMC4046803.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    21. Synapto-depressive effects of amyloid beta require PICK1. Eur J Neurosci. 2014 Apr; 39(7):1225-33. Alfonso S, Kessels HW, Banos CC, Chan TR, Lin ET, Kumaravel G, Scannevin RH, Rhodes KJ, Huganir R, Guckian KM, Dunah AW, Malinow R. PMID: 24713001; PMCID: PMC3983572.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    22. Negative learning bias is associated with risk aversion in a genetic animal model of depression. Front Hum Neurosci. 2014; 8:1. Shabel SJ, Murphy RT, Malinow R. PMID: 24474914; PMCID: PMC3893716.
      View in: PubMed   Mentions: 5  
    23. GluA1 trafficking and metabotropic NMDA: addressing results from other laboratories inconsistent with ours. Philos Trans R Soc Lond B Biol Sci. 2014 Jan 05; 369(1633):20130145. Nabavi S, Fox R, Alfonso S, Aow J, Malinow R. PMID: 24298147; PMCID: PMC3843877.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    24. Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI). Neuron. 2013 Jul 24; 79(2):241-53. Lin JY, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY. PMID: 23889931; PMCID: PMC3804158.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    25. Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4033-8. Kessels HW, Nabavi S, Malinow R. PMID: 23431156; PMCID: PMC3593880.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    26. Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4027-32. Nabavi S, Kessels HW, Alfonso S, Aow J, Fox R, Malinow R. PMID: 23431133; PMCID: PMC3593861.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    27. Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. Neuron. 2012 May 10; 74(3):475-81. Shabel SJ, Proulx CD, Trias A, Murphy RT, Malinow R. PMID: 22578499; PMCID: PMC3471532.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    28. Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory. J Biol Chem. 2012 Apr 13; 287(16):12879-85. Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC. PMID: 22378786; PMCID: PMC3339930.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    29. Compartmentalized versus global synaptic plasticity on dendrites controlled by experience. Neuron. 2011 Dec 22; 72(6):1001-11. Makino H, Malinow R. PMID: 22196335; PMCID: PMC3310180.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    30. New developments on the role of NMDA receptors in Alzheimer's disease. Curr Opin Neurobiol. 2012 Jun; 22(3):559-63. Malinow R. PMID: 21962484; PMCID: PMC3405538.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    31. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature. 2011 Feb 24; 470(7335):535-9. Li B, Piriz J, Mirrione M, Chung C, Proulx CD, Schulz D, Henn F, Malinow R. PMID: 21350486; PMCID: PMC3285101.
      View in: PubMed   Mentions: 261     Fields:    Translation:AnimalsCells
    32. The prion protein as a receptor for amyloid-beta. Nature. 2010 Aug 12; 466(7308):E3-4; discussion E4-5. Kessels HW, Nguyen LN, Nabavi S, Malinow R. PMID: 20703260; PMCID: PMC3057871.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    33. AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis. Neuron. 2009 Nov 12; 64(3):381-90. Makino H, Malinow R. PMID: 19914186; PMCID: PMC2999463.
      View in: PubMed   Mentions: 254     Fields:    Translation:AnimalsCells
    34. Synaptic AMPA receptor plasticity and behavior. Neuron. 2009 Feb 12; 61(3):340-50. Kessels HW, Malinow R. PMID: 19217372; PMCID: PMC3917551.
      View in: PubMed   Mentions: 497     Fields:    Translation:HumansAnimalsCells
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