Roberto Malinow

InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0634
La Jolla CA 92093
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    SYNPLA: A scaleable method for monitoring circuit-specific learning-induced changes in synaptic strength
    NIH/NIMH U01MH109113Sep 25, 2015 - Jun 30, 2018
    Role: Principal Investigator
    A Synaptic Locus Controlling Behavioral Depression
    NIH/NIMH R01MH091119Jul 1, 2010 - Feb 28, 2021
    Role: Principal Investigator
    Novel roles by glutamatergic receptors in the synaptic effects of beta amyloid
    NIH/NIA R01AG032132Apr 1, 1995 - Jun 30, 2018
    Role: Principal Investigator
    Protein Kinases in Synaptic Plasticity
    NIH/NINDS R01NS032827Apr 1, 1995 - Feb 29, 2008
    Role: Principal Investigator
    Mechanisms of LTP:AMPA receptor dynamics
    NIH/NIMH R01MH049159May 1, 1992 - Jan 31, 2020
    Role: Principal Investigator
    Mechanisms of synaptic LTP
    NIH/NIMH R37MH049159May 1, 1992 - Apr 30, 2010
    Role: Principal Investigator
    NIH/NIMH R29MH049159May 1, 1992 - Apr 30, 1997
    Role: Principal Investigator
    NIH/NINDS F32NS007752Jul 22, 1985
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Proulx CD, Aronson S, Milivojevic D, Molina C, Loi A, Monk B, Shabel SJ, Malinow R. A neural pathway controlling motivation to exert effort. Proc Natl Acad Sci U S A. 2018 May 11. PMID: 29752382.
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    2. Carrico ZM, Le G, Malinow R. A fluorescence assay for detecting amyloid-ß using the cytomegalovirus enhancer/promoter. J Biol Methods. 2017; 4(3). PMID: 29457040.
      View in: PubMed
    3. Park H, Rhee J, Park K, Han JS, Malinow R, Chung C. Exposure to Stressors Facilitates Long-Term Synaptic Potentiation in the Lateral Habenula. J Neurosci. 2017 Jun 21; 37(25):6021-6030. PMID: 28539417.
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    4. Reinders NR, Pao Y, Renner MC, da Silva-Matos CM, Lodder TR, Malinow R, Kessels HW. Amyloid-ß effects on synapses and memory require AMPA receptor subunit GluA3. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6526-E6534. PMID: 27708157.
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    5. Dore K, Aow J, Malinow R. The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging. Front Synaptic Neurosci. 2016; 8:20. PMID: 27516738; PMCID: PMC4963461.
    6. Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Gain-of-function mutations in protein kinase Ca (PKCa) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016 05 10; 9(427):ra47. PMID: 27165780.
      View in: PubMed
    7. Malinow R. Depression: Ketamine steps out of the darkness. Nature. 2016 05 26; 533(7604):477-8. PMID: 27144350.
      View in: PubMed
    8. Landgraf D, Long JE, Proulx CD, Barandas R, Malinow R, Welsh DK. Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice. Biol Psychiatry. 2016 12 01; 80(11):827-835. PMID: 27113500.
      View in: PubMed
    9. Aow J, Dore K, Malinow R. Conformational signaling required for synaptic plasticity by the NMDA receptor complex. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14711-6. PMID: 26553983; PMCID: PMC4664326.
    10. Dore K, Aow J, Malinow R. Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14705-10. PMID: 26553997; PMCID: PMC4664357.
    11. Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 04; 290(36):21845-56. PMID: 26187466; PMCID: PMC4571940.
    12. Shabel SJ, Proulx CD, Piriz J, Malinow R. Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment. Science. 2014 Sep 19; 345(6203):1494-8. PMID: 25237099; PMCID: PMC4305433.
    13. Proulx CD, Hikosaka O, Malinow R. Reward processing by the lateral habenula in normal and depressive behaviors. Nat Neurosci. 2014 Sep; 17(9):1146-52. PMID: 25157511; PMCID: PMC4305435.
    14. Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R. Engineering a memory with LTD and LTP. Nature. 2014 Jul 17; 511(7509):348-52. PMID: 24896183; PMCID: PMC4210354.
    15. Viger ML, Sheng W, Doré K, Alhasan AH, Carling CJ, Lux J, de Gracia Lux C, Grossman M, Malinow R, Almutairi A. Near-infrared-induced heating of confined water in polymeric particles for efficient payload release. ACS Nano. 2014 May 27; 8(5):4815-26. PMID: 24717072; PMCID: PMC4046803.
    16. Alfonso S, Kessels HW, Banos CC, Chan TR, Lin ET, Kumaravel G, Scannevin RH, Rhodes KJ, Huganir R, Guckian KM, Dunah AW, Malinow R. Synapto-depressive effects of amyloid beta require PICK1. Eur J Neurosci. 2014 Apr; 39(7):1225-33. PMID: 24713001; PMCID: PMC3983572.
    17. Shabel SJ, Murphy RT, Malinow R. Negative learning bias is associated with risk aversion in a genetic animal model of depression. Front Hum Neurosci. 2014; 8:1. PMID: 24474914; PMCID: PMC3893716.
    18. Nabavi S, Fox R, Alfonso S, Aow J, Malinow R. GluA1 trafficking and metabotropic NMDA: addressing results from other laboratories inconsistent with ours. Philos Trans R Soc Lond B Biol Sci. 2014 Jan 05; 369(1633):20130145. PMID: 24298147; PMCID: PMC3843877.
    19. Li K, Zhou T, Liao L, Yang Z, Wong C, Henn F, Malinow R, Yates JR, Hu H. ßCaMKII in lateral habenula mediates core symptoms of depression. Science. 2013 Aug 30; 341(6149):1016-20. PMID: 23990563; PMCID: PMC3932364.
    20. Lin JY, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY. Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI). Neuron. 2013 Jul 24; 79(2):241-53. PMID: 23889931; PMCID: PMC3804158.
    21. Nabavi S, Kessels HW, Alfonso S, Aow J, Fox R, Malinow R. Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4027-32. PMID: 23431133; PMCID: PMC3593861.
    22. Kessels HW, Nabavi S, Malinow R. Metabotropic NMDA receptor function is required for ß-amyloid-induced synaptic depression. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4033-8. PMID: 23431156; PMCID: PMC3593880.
    23. Sheng M, Malinow R, Huganir R. Neuroscience: Strength in numbers. Nature. 2013 Jan 24; 493(7433):482-3. PMID: 23344353; PMCID: PMC3931552.
    24. Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T. Disrupted cortical function underlies behavior dysfunction due to social isolation. J Clin Invest. 2012 Jul; 122(7):2690-701. PMID: 22706303; PMCID: PMC3387818.
    25. Shabel SJ, Proulx CD, Trias A, Murphy RT, Malinow R. Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. Neuron. 2012 May 10; 74(3):475-81. PMID: 22578499; PMCID: PMC3471532.
    26. Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC. Cellular pharmacology of protein kinase M? (PKM?) contrasts with its in vitro profile: implications for PKM? as a mediator of memory. J Biol Chem. 2012 Apr 13; 287(16):12879-85. PMID: 22378786; PMCID: PMC3339930.
    27. Makino H, Malinow R. Compartmentalized versus global synaptic plasticity on dendrites controlled by experience. Neuron. 2011 Dec 22; 72(6):1001-11. PMID: 22196335; PMCID: PMC3310180.
    28. Miyazaki T, Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi T. Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex. Brain Res. 2012 Jan 30; 1435:1-7. PMID: 22197698; PMCID: PMC3916145.
    29. Malinow R. New developments on the role of NMDA receptors in Alzheimer's disease. Curr Opin Neurobiol. 2012 Jun; 22(3):559-63. PMID: 21962484; PMCID: PMC3405538.
    30. Li B, Piriz J, Mirrione M, Chung C, Proulx CD, Schulz D, Henn F, Malinow R. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature. 2011 Feb 24; 470(7335):535-9. PMID: 21350486; PMCID: PMC3285101.
    31. Malenka RC, Malinow R. Alzheimer's disease: Recollection of lost memories. Nature. 2011 Jan 06; 469(7328):44-5. PMID: 21209657; PMCID: PMC3917549.
    32. Kessels HW, Nguyen LN, Nabavi S, Malinow R. The prion protein as a receptor for amyloid-beta. Nature. 2010 Aug 12; 466(7308):E3-4; discussion E4-5. PMID: 20703260; PMCID: PMC3057871.
    33. Malinow R, Hayashi Y, Maletic-Savatic M, Zaman SH, Poncer JC, Shi SH, Esteban JA, Osten P, Seidenman K. Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5406. PMID: 20360360; PMCID: PMC3923632.
    34. Wei W, Nguyen LN, Kessels HW, Hagiwara H, Sisodia S, Malinow R. Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci. 2010 Feb; 13(2):190-6. PMID: 20037574; PMCID: PMC3310198.
    35. Makino H, Malinow R. AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis. Neuron. 2009 Nov 12; 64(3):381-90. PMID: 19914186; PMCID: PMC2999463.
    36. Li B, Devidze N, Barengolts D, Prostak N, Sphicas E, Apicella AJ, Malinow R, Emamian ES. NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity. J Neurosci. 2009 Sep 23; 29(38):11965-72. PMID: 19776282; PMCID: PMC2804063.
    37. Kessels HW, Kopec CD, Klein ME, Malinow R. Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution. Nat Neurosci. 2009 Jul; 12(7):888-96. PMID: 19543281; PMCID: PMC3922706.
    38. Nadif Kasri N, Nakano-Kobayashi A, Malinow R, Li B, Van Aelst L. The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Genes Dev. 2009 Jun 01; 23(11):1289-302. PMID: 19487570; PMCID: PMC2701582.
    39. Kessels HW, Malinow R. Synaptic AMPA receptor plasticity and behavior. Neuron. 2009 Feb 12; 61(3):340-50. PMID: 19217372; PMCID: PMC3917551.
    40. Fernández de Sevilla D, Núñez A, Borde M, Malinow R, Buño W. Cholinergic-mediated IP3-receptor activation induces long-lasting synaptic enhancement in CA1 pyramidal neurons. J Neurosci. 2008 Feb 06; 28(6):1469-78. PMID: 18256268.
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    41. Kopec CD, Real E, Kessels HW, Malinow R. GluR1 links structural and functional plasticity at excitatory synapses. J Neurosci. 2007 Dec 12; 27(50):13706-18. PMID: 18077682.
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    42. Venkitaramani DV, Chin J, Netzer WJ, Gouras GK, Lesne S, Malinow R, Lombroso PJ. Beta-amyloid modulation of synaptic transmission and plasticity. J Neurosci. 2007 Oct 31; 27(44):11832-7. PMID: 17978019; PMCID: PMC2671021.
    43. Hu H, Real E, Takamiya K, Kang MG, Ledoux J, Huganir RL, Malinow R. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell. 2007 Oct 05; 131(1):160-73. PMID: 17923095.
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    44. Li B, Woo RS, Mei L, Malinow R. The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. Neuron. 2007 May 24; 54(4):583-97. PMID: 17521571; PMCID: PMC2031848.
    45. Ehrlich I, Klein M, Rumpel S, Malinow R. PSD-95 is required for activity-driven synapse stabilization. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4176-81. PMID: 17360496; PMCID: PMC1820728.
    46. Kopec C, Malinow R. Neuroscience. Matters of size. Science. 2006 Dec 08; 314(5805):1554-5. PMID: 17158312.
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    47. Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 2006 Dec 07; 52(5):831-43. PMID: 17145504; PMCID: PMC1850952.
    48. Rial Verde EM, Lee-Osbourne J, Worley PF, Malinow R, Cline HT. Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron. 2006 Nov 09; 52(3):461-74. PMID: 17088212; PMCID: PMC3951199.
    49. Boehm J, Ehrlich I, Hsieh H, Malinow R. Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity. Learn Mem. 2006 Sep-Oct; 13(5):562-5. PMID: 16980545.
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    50. Kopec CD, Kessels HW, Bush DE, Cain CK, LeDoux JE, Malinow R. A robust automated method to analyze rodent motion during fear conditioning. Neuropharmacology. 2007 Jan; 52(1):228-33. PMID: 16926033.
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    51. Boehm J, Kang MG, Johnson RC, Esteban J, Huganir RL, Malinow R. Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1. Neuron. 2006 Jul 20; 51(2):213-25. PMID: 16846856.
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    52. Kopec CD, Li B, Wei W, Boehm J, Malinow R. Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J Neurosci. 2006 Feb 15; 26(7):2000-9. PMID: 16481433.
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    53. Barria A, Malinow R. NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. Neuron. 2005 Oct 20; 48(2):289-301. PMID: 16242409.
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    54. Rumpel S, LeDoux J, Zador A, Malinow R. Postsynaptic receptor trafficking underlying a form of associative learning. Science. 2005 Apr 01; 308(5718):83-8. PMID: 15746389.
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    55. Ehrlich I, Malinow R. Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity. J Neurosci. 2004 Jan 28; 24(4):916-27. PMID: 14749436.
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    56. Kolleker A, Zhu JJ, Schupp BJ, Qin Y, Mack V, Borchardt T, Köhr G, Malinow R, Seeburg PH, Osten P. Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors. Neuron. 2003 Dec 18; 40(6):1199-212. PMID: 14687553.
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    57. Seidenman KJ, Steinberg JP, Huganir R, Malinow R. Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells. J Neurosci. 2003 Oct 08; 23(27):9220-8. PMID: 14534256.
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    58. Malinow R. AMPA receptor trafficking and long-term potentiation. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29; 358(1432):707-14. PMID: 12740116; PMCID: PMC1693162.
    59. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 2003 Mar 27; 37(6):925-37. PMID: 12670422.
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    60. Takahashi T, Svoboda K, Malinow R. Experience strengthening transmission by driving AMPA receptors into synapses. Science. 2003 Mar 07; 299(5612):1585-8. PMID: 12624270.
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    61. Esteban JA, Shi SH, Wilson C, Nuriya M, Huganir RL, Malinow R. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat Neurosci. 2003 Feb; 6(2):136-43. PMID: 12536214.
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    62. Zhu JJ, Qin Y, Zhao M, Van Aelst L, Malinow R. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell. 2002 Aug 23; 110(4):443-55. PMID: 12202034.
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    63. Barria A, Malinow R. Subunit-specific NMDA receptor trafficking to synapses. Neuron. 2002 Jul 18; 35(2):345-53. PMID: 12160751.
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    64. Piccini A, Malinow R. Critical postsynaptic density 95/disc large/zonula occludens-1 interactions by glutamate receptor 1 (GluR1) and GluR2 required at different subcellular sites. J Neurosci. 2002 Jul 01; 22(13):5387-92. PMID: 12097490.
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    65. Zhu JJ, Malinow R. Acute versus chronic NMDA receptor blockade and synaptic AMPA receptor delivery. Nat Neurosci. 2002 Jun; 5(6):513-4. PMID: 11967548.
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    66. Poncer JC, Esteban JA, Malinow R. Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II. J Neurosci. 2002 Jun 01; 22(11):4406-11. PMID: 12040047.
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    67. Malinow R, Malenka RC. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci. 2002; 25:103-26. PMID: 12052905.
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