Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Catriona Jamieson

    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Research Interests
      Dr. Jamieson specialized in myeloproliferative disorders (MPDs) and leukemia. Myeloproliferative neoplasms are a family of uncommon but not rare degenerative disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart attack, stroke, deep venous thrombosis, and pulmonary emboli and can develop into acute myelogenous leukemia. Although some effective treatments are available, they are laden with serious side effects. In addition, individuals can become resistant to the treatments. Dr. Jamieson studies the mutant stem cells and progenitor cells in myeloproliferative neoplasms. These cells can give rise to cancer stem cells. Cancer stem cells may lie low to evade chemotherapy and then activate again later, causing disease progression and resistance to treatment. Her goal is to find more selective, less toxic therapies. In the past two years, Dr. Jamieson’s stem-cell research studies have taken a great leap: from identifying a promising treatment in the laboratory to opening and completing the first clinical trial to target cancer stem cells in humans. This trial is the result of teamwork that has brought together her discoveries in myeloproliferative neoplasms and a local pharmaceutical company’s drug development track.

      Education and Training
      BS - Biology-Genetics, University of British Columbia - 1987
      Ph.D. - Microbiology, University of British Columbia - 1992
      MD - University of British Columbia - 1995
      Resident - University of British Columbia - 1995-1998
      Fellow, Bone Marrow Transplant - University of British Columbia - 1998
      Fellow, Bone Marrow Transplant - Stanford University - 1999-2002
      Postdoctoral Research Fellow - Stanford University - 2002-2005

      Collapse Research 
      Collapse Research Activities and Funding
      Defining the Niche-dependent Role of RNA Editing in Aged and MDS Hematopoietic Stem and Progenitor Cell Dysfunction
      NIH/NIDDK R01DK114468Aug 20, 2017 - Jul 31, 2018
      Role: Principal Investigator
      Characterization of the Role of ADAR1 in Oncogenic Transformation of Progenitors
      NIH/NCI R01CA205944Dec 8, 2016 - Nov 30, 2021
      Role: Principal Investigator
      (PQC2) Niche-responsive RNA editing by ADAR1 in dormant multiple myeloma initiating cell maintenance
      NIH/NCI R21CA194679May 1, 2015 - Apr 30, 2017
      Role: Principal Investigator
      Identifying microRNA Targets for Early Detection of Myeloproliferative Neoplasms
      NIH/NCI R21CA189705Apr 1, 2015 - Mar 31, 2017
      Role: Principal Investigator
      2009 Stem Cells and Cancer Gordon Conference
      NIH/NCI R13CA139606Sep 1, 2009 - Aug 31, 2010
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lazzari E, Mondala PK, Santos ND, Miller AC, Pineda G, Jiang Q, Leu H, Ali SA, Ganesan AP, Wu CN, Costello C, Minden M, Chiaramonte R, Stewart AK, Crews LA, Jamieson C. Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nat Commun. 2017 Dec 04; 8(1):1922. PMID: 29203771.
        View in: PubMed
      2. Jamieson C. Cancer: Bad blood promotes tumour progression. Nature. 2017 Sep 27; 549(7673):465-466. PMID: 28959960.
        View in: PubMed
      3. Jiang Q, Crews LA, Holm F, Jamieson C. RNA editing-dependent epitranscriptome diversity in cancer stem cells. Nat Rev Cancer. 2017 Jun; 17(6):381-392. PMID: 28416802.
        View in: PubMed
      4. Mesa R, Jamieson C, Bhatia R, Deininger MW, Gerds AT, Gojo I, Gotlib J, Gundabolu K, Hobbs G, Klisovic RB, Kropf P, Mohan SR, Oh S, Padron E, Podoltsev N, Pollyea DA, Rampal R, Rein LA, Scott B, Snyder DS, Stein BL, Verstovsek S, Wadleigh M, Wang ES, Bergman MA, Gregory KM, Sundar H. Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016 Dec; 14(12):1572-1611. PMID: 27956542.
        View in: PubMed
      5. Ha D, Liao X, Wang HY, Jamieson C, Magaña M, Makani S. Thoracic Extramedullary Hematopoiesis Mimicking Metastatic Cancer. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):343-346. PMID: 27479013.
        View in: PubMed
      6. Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson C. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016 Nov 03; 19(5):599-612. PMID: 27570067.
        View in: PubMed
      7. Zipeto MA, Court AC, Sadarangani A, Delos Santos NP, Balaian L, Chun HJ, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, Frazer KA, Marra MA, Crews LA, Jiang Q, Jamieson C. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 Aug 04; 19(2):177-191. PMID: 27292188; PMCID: PMC4975616 [Available on 08/04/17].
      8. Pineda G, Lennon KM, Delos Santos NP, Lambert-Fliszar F, Riso GL, Lazzari E, Marra MA, Morris S, Sakaue-Sawano A, Miyawaki A, Jamieson C. Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche. Sci Rep. 2016 Apr 04; 6:23885. PMID: 27041210; PMCID: PMC4819192.
      9. Holm F, Hellqvist E, Mason CN, Ali SA, Delos-Santos N, Barrett CL, Chun HJ, Minden MD, Moore RA, Marra MA, Runza V, Frazer KA, Sadarangani A, Jamieson C. Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15444-9. PMID: 26621726; PMCID: PMC4687548.
      10. Jamieson C, Hasserjian R, Gotlib J, Cortes J, Stone R, Talpaz M, Thiele J, Rodig S, Pozdnyakova O. Effect of treatment with a JAK2-selective inhibitor, fedratinib, on bone marrow fibrosis in patients with myelofibrosis. J Transl Med. 2015 Sep 10; 13:294. PMID: 26357842; PMCID: PMC4566296.
      11. Zipeto MA, Jiang Q, Melese E, Jamieson C. RNA rewriting, recoding, and rewiring in human disease. Trends Mol Med. 2015 Sep; 21(9):549-59. PMID: 26259769.
        View in: PubMed
      12. Martinelli G, Oehler VG, Papayannidis C, Courtney R, Shaik MN, Zhang X, O'Connell A, McLachlan KR, Zheng X, Radich J, Baccarani M, Kantarjian HM, Levin WJ, Cortes JE, Jamieson C. Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study. Lancet Haematol. 2015 Aug; 2(8):e339-46. PMID: 26688487.
        View in: PubMed
      13. Choi MY, Widhopf GF, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J, Prussak C, Carson DA, Jamieson C, Kipps TJ. Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15 Suppl:S167-9. PMID: 26297272; PMCID: PMC4548279.
      14. Stein BL, Gotlib J, Arcasoy M, Nguyen MH, Shah N, Moliterno A, Jamieson C, Pollyea DA, Scott B, Wadleigh M, Levine R, Komrokji R, Klisovic R, Gundabolu K, Kropf P, Wetzler M, Oh ST, Ribeiro R, Paschal R, Mohan S, Podoltsev N, Prchal J, Talpaz M, Snyder D, Verstovsek S, Mesa RA. Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms. J Natl Compr Canc Netw. 2015 Apr; 13(4):424-34. PMID: 25870379.
        View in: PubMed
      15. Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson C. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21; 13:98. PMID: 25889765; PMCID: PMC4414375.
      16. DeBoever C, Ghia EM, Shepard PJ, Rassenti L, Barrett CL, Jepsen K, Jamieson C, Carson D, Kipps TJ, Frazer KA. Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers. PLoS Comput Biol. 2015 Mar; 11(3):e1004105. PMID: 25768983; PMCID: PMC4358997.
      17. Crews LA, Jiang Q, Zipeto MA, Lazzari E, Court AC, Ali S, Barrett CL, Frazer KA, Jamieson C. An RNA editing fingerprint of cancer stem cell reprogramming. J Transl Med. 2015 Feb 12; 13:52. PMID: 25889244; PMCID: PMC4341880.
      18. Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson C, Thistlethwaite PA, Harismendy O, Carson DA, Frazer KA. Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer. PLoS One. 2013; 8(3):e58714. PMID: 23527012; PMCID: PMC3604164.
      19. Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson C. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. PMID: 23333150; PMCID: PMC3968867.
      20. Newton IG, Plaisted WC, Messina-Graham S, Abrahamsson Schairer AE, Shih AY, Snyder EY, Jamieson C, Mattrey RF. Optical imaging of progenitor cell homing to patient-derived tumors. Contrast Media Mol Imaging. 2012 Nov-Dec; 7(6):525-36. PMID: 22991319; PMCID: PMC4091721.
      21. Crews LA, Jamieson C. Selective elimination of leukemia stem cells: hitting a moving target. Cancer Lett. 2013 Sep 10; 338(1):15-22. PMID: 22906415.
        View in: PubMed
      22. Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson C. NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725. PMID: 22768113; PMCID: PMC3387267.
      23. Crews LA, Jamieson C. Chronic myeloid leukemia stem cell biology. Curr Hematol Malig Rep. 2012 Jun; 7(2):125-32. PMID: 22467334; PMCID: PMC3342507.
      24. Raheem O, Kulidjian AA, Wu C, Jeong YB, Yamaguchi T, Smith KM, Goff D, Leu H, Morris SR, Cacalano NA, Masuda K, Jamieson CH, Kane CJ, Jamieson C. A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions. J Transl Med. 2011 Oct 28; 9:185. PMID: 22035283; PMCID: PMC3269442.
      25. Pardanani A, Gotlib JR, Jamieson C, Cortes JE, Talpaz M, Stone RM, Silverman MH, Gilliland DG, Shorr J, Tefferi A. Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol. 2011 Mar 01; 29(7):789-96. PMID: 21220608; PMCID: PMC4979099.
      26. Rice KN, Jamieson C. Molecular pathways to CML stem cells. Int J Hematol. 2010 Jun; 91(5):748-52. PMID: 20533007.
        View in: PubMed
      27. Jamieson C. Split ends in CML: divergent roles of Hes1. Blood. 2010 Apr 08; 115(14):2726-7. PMID: 20378758.
        View in: PubMed
      28. Goff D, Jamieson C. Cycling toward elimination of leukemic stem cells. Cell Stem Cell. 2010 Apr 02; 6(4):296-7. PMID: 20362532.
        View in: PubMed
      29. Jaiswal S, Jamieson C, Pang WW, Park CY, Chao MP, Majeti R, Traver D, van Rooijen N, Weissman IL. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009 Jul 23; 138(2):271-85. PMID: 19632178; PMCID: PMC2775564.
      30. Abrahamsson AE, Geron I, Gotlib J, Dao KH, Barroga CF, Newton IG, Giles FJ, Durocher J, Creusot RS, Karimi M, Jones C, Zehnder JL, Keating A, Negrin RS, Weissman IL, Jamieson C. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3925-9. PMID: 19237556; PMCID: PMC2646624.
      31. Jamieson C. The MLLgnant consequences of reverting to an embryonic transcriptional program. Cell Stem Cell. 2009 Feb 06; 4(2):97-8. PMID: 19200795.
        View in: PubMed
      32. Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson C, Wang JY. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17967-72. PMID: 19004799.
        View in: PubMed
      33. Jamieson C, Barroga CF, Vainchenker WP. Miscreant myeloproliferative disorder stem cells. Leukemia. 2008 Nov; 22(11):2011-9. PMID: 18923436.
        View in: PubMed
      34. Kavalerchik E, Goff D, Jamieson C. Chronic myeloid leukemia stem cells. J Clin Oncol. 2008 Jun 10; 26(17):2911-5. PMID: 18539972.
        View in: PubMed
      35. Geron I, Abrahamsson AE, Barroga CF, Kavalerchik E, Gotlib J, Hood JD, Durocher J, Mak CC, Noronha G, Soll RM, Tefferi A, Kaushansky K, Jamieson C. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008 Apr; 13(4):321-30. PMID: 18394555.
        View in: PubMed
      36. Jamieson C. Chronic myeloid leukemia stem cells. Hematology Am Soc Hematol Educ Program. 2008; 436-42. PMID: 19074122.
        View in: PubMed
      37. Jamieson C, Gotlib J, Durocher JA, Chao MP, Mariappan MR, Lay M, Jones C, Zehnder JL, Lilleberg SL, Weissman IL. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6224-9. PMID: 16603627; PMCID: PMC1434515.
      38. Jamieson C, Weissman IL, Passegué E. Chronic versus acute myelogenous leukemia: a question of self-renewal. Cancer Cell. 2004 Dec; 6(6):531-3. PMID: 15607956.
        View in: PubMed
      39. Jamieson C, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, Sawyers CL, Weissman IL. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004 Aug 12; 351(7):657-67. PMID: 15306667.
        View in: PubMed