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    Geoffrey Wahl

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
    Phone858-453-4100
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      Collapse Research 
      Collapse Research Activities and Funding
      Combining single cell approaches and a developmental perspective to discover stem cell control circuits and the cellular and molecular bases of cancer heterogeneity
      NIH/NCI R35CA197687Aug 1, 2015 - Jul 31, 2022
      Role: Principal Investigator
      High throughput screen for inhibitors of the mdm2/mdmx interaction
      NIH/NIMH R03MH089489Feb 1, 2010 - Nov 30, 2011
      Role: Principal Investigator
      Mouse Models to Elucidate p53 Regulatory Mechanisms
      NIH/NCI R01CA100845Apr 15, 2003 - Mar 31, 2009
      Role: Principal Investigator
      DECONVOLUTION MICROSCOPE FOR LIVE CELL IMAGING
      NIH/NCRR S10RR013692Feb 16, 1999 - Feb 15, 2000
      Role: Principal Investigator
      DNA REPLICATION, CELL CYCLE CONTROL AND GENOME FLUIDITY
      NIH/NIGMS R01GM051104Aug 1, 1993 - Jul 31, 1998
      Role: Principal Investigator
      Mechanisms of Genetic Instability and Tumor Suppression
      NIH/NCI R01CA061449Jul 1, 1993 - Jul 31, 2011
      Role: Principal Investigator
      MOLECULAR GENETIC ANALYSIS OF MAMMALIAN DNA REPLICATION
      NIH/NCI R01CA048405Aug 1, 1988 - Mar 31, 2005
      Role: Principal Investigator
      DETECTION AND CURING OF AMPLIFIED GENES IN CANCER
      NIH/NCI U01CA048405Aug 1, 1988 - Jul 31, 1995
      Role: Principal Investigator
      FASEB RESEARCH CONF--CELLULAR AND MOLECULAR GENETICS
      NIH/NCI R13CA049116Jul 1, 1988 - Jun 30, 1989
      Role: Principal Investigator
      Cell Regulation, Differentiation and Cancer
      NIH/NCI T32CA009370Sep 1, 1980 - Jun 30, 2022
      Role: Co-Principal Investigator
      DRUG RESISTANCE AND GENE AMPLIFICATION IN EUKARYOTES
      NIH/NIGMS R01GM027754Apr 1, 1980 - Jun 30, 1993
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Trejo CL, Luna G, Dravis C, Spike BT, Wahl G. Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. NPJ Breast Cancer. 2017; 3:16. PMID: 28649656.
        View in: PubMed
      2. Wahl G, Spike BT. Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer. 2017; 3:14. PMID: 28649654.
        View in: PubMed
      3. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl G, Bafna V, Mischel PS. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 Feb 08. PMID: 28178237.
        View in: PubMed
      4. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl G, Verma IM, Laurent LC, Izpisua Belmonte JC. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016; 7:10743. PMID: 26899176.
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      5. Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl G. Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep. 2015 Sep 29; 12(12):2035-48. PMID: 26365194.
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      6. Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl G, Balmain A. The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 Sep; 55(9):1387-96. PMID: 26310697.
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      7. Rozhok AI, Wahl G, DeGregori J. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila). 2015 Sep; 8(9):762-4. PMID: 26122457.
        View in: PubMed
      8. Pfefferle AD, Spike BT, Wahl G, Perou CM. Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat. 2015 Jan; 149(2):425-37. PMID: 25575446.
        View in: PubMed
      9. Li YC, Rodewald LW, Hoppmann C, Wong ET, Lebreton S, Safar P, Patek M, Wang L, Wertman KF, Wahl G. A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11; 9(5):1946-58. PMID: 25464845.
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      10. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl G, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. Vitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. PMID: 25259922.
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      11. Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl G, Gray PC. CRIPTO/GRP78 Signaling Maintains Fetal and Adult Mammary Stem Cells Ex Vivo. Stem Cell Reports. 2014 Apr 8; 2(4):427-39. PMID: 24749068.
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      12. Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl G, Rosen JM, Perou CM. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013; 14(11):R125. PMID: 24220145.
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      13. He G, Zhang YW, Lee JH, Zeng SX, Wang YV, Luo Z, Dong XC, Viollet B, Wahl G, Lu H. AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity. Mol Cell Biol. 2014 Jan; 34(2):148-57. PMID: 24190973.
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      14. Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl G, Rathmell WK. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem. 2013 Sep 6; 288(36):26301-10. PMID: 23893409.
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      15. Makarem M, Spike BT, Dravis C, Kannan N, Wahl G, Eaves CJ. Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia. 2013 Jun; 18(2):209-19. PMID: 23624881.
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      16. Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl G. Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6991-6. PMID: 23559372.
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      17. Green JL, Bauer M, Yum KW, Li YC, Cox ML, Willert K, Wahl G. Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. PLoS One. 2013; 8(3):e58395. PMID: 23516471.
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      18. Wade M, Li YC, Wahl G. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 2013 Feb; 13(2):83-96. PMID: 23303139.
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      19. Li YC, Wahl G. What a difference a phosphate makes: life or death decided by a single amino acid in MDM2. Cancer Cell. 2012 May 15; 21(5):595-6. PMID: 22624708.
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      20. Lee JH, Jin Y, He G, Zeng SX, Wang YV, Wahl G, Lu H. Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3? inactivation of MDMX protein. J Biol Chem. 2012 Jun 15; 287(25):20898-903. PMID: 22556425.
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      21. Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl G. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell. 2012 Feb 3; 10(2):183-97. PMID: 22305568.
        View in: PubMed
      22. Wade M, Li YC, Matani AS, Braun SM, Milanesi F, Rodewald LW, Wahl G. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene. 2012 Nov 8; 31(45):4789-97. PMID: 22266850.
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      23. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl G. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 1; 25(13):1426-38. PMID: 21724834.
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      24. Spike BT, Wahl G. p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer. 2011 Apr; 2(4):404-19. PMID: 21779509.
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      25. Mizuno H, Spike BT, Wahl G, Levine AJ. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22745-50. PMID: 21149740.
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      26. Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl G, Walensky LD. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16; 18(5):411-22. PMID: 21075307.
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      27. Wade M, Wang YV, Wahl G. The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol. 2010 May; 20(5):299-309. PMID: 20172729.
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      28. Wang YV, Wade M, Wahl G. Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo. Cell Cycle. 2009 Nov 1; 8(21):3443-4. PMID: 19838055.
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      29. Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl G, Nister M, Weinberg WC. The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol. 2009 Oct; 219(2):263-74. PMID: 19718706.
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      30. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl G, Izpisúa Belmonte JC. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009 Aug 27; 460(7259):1140-4. PMID: 19668186.
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      31. Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl G. Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell. 2009 Jul 7; 16(1):33-43. PMID: 19573810.
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      32. Wade M, Wahl G. Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res. 2009 Jan; 7(1):1-11. PMID: 19147532.
        View in: PubMed
      33. Wade M, Rodewald LW, Espinosa JM, Wahl G. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle. 2008 Jul 1; 7(13):1973-82. PMID: 18604177.
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      34. Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl G. Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12365-70. PMID: 17640893.
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      35. Toledo F, Wahl G. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Int J Biochem Cell Biol. 2007; 39(7-8):1476-82. PMID: 17499002.
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      36. Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl G. Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 2007 Feb; 27(4):1425-32. PMID: 17158931.
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      37. Toledo F, Wahl G. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer. 2006 Dec; 6(12):909-23. PMID: 17128209.
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      38. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl G. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006 Oct 1; 66(19):9339-44. PMID: 16990346.
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      39. Wade M, Wong ET, Tang M, Stommel JM, Wahl G. Hdmx modulates the outcome of p53 activation in human tumor cells. J Biol Chem. 2006 Nov 3; 281(44):33036-44. PMID: 16905769.
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      40. Toledo F, Liu CW, Lee CJ, Wahl G. RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic Acids Res. 2006; 34(13):e92. PMID: 16870721.
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      41. Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 2006 Jun; 13(6):927-34. PMID: 16543935.
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      42. Wahl G. Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo. Cell Death Differ. 2006 Jun; 13(6):973-83. PMID: 16575406.
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      43. Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl G. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell. 2006 Apr; 9(4):273-85. PMID: 16616333.
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      44. Tang M, Wahl G, Nistér M. Explaining the biological activity of transactivation-deficient p53 variants. Nat Genet. 2006 Apr; 38(4):395-6; author reply 396-7. PMID: 16570054.
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      45. Wade M, Wahl G. c-Myc, genome instability, and tumorigenesis: the devil is in the details. Curr Top Microbiol Immunol. 2006; 302:169-203. PMID: 16620029.
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      46. Wong ET, Kolman JL, Li YC, Mesner LD, Hillen W, Berens C, Wahl G. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res. 2005; 33(17):e147. PMID: 16204450.
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      47. Buzina A, Aladjem MI, Kolman JL, Wahl G, Ellis J. Initiation of DNA replication at the human beta-globin 3' enhancer. Nucleic Acids Res. 2005; 33(14):4412-24. PMID: 16085752.
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      48. Krummel KA, Lee CJ, Toledo F, Wahl G. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10188-93. PMID: 16006521.
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      49. Nistér M, Tang M, Zhang XQ, Yin C, Beeche M, Hu X, Enblad G, van Dyke T, Wahl G. p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene. 2005 May 19; 24(22):3563-73. PMID: 15750633.
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      50. Stommel JM, Wahl G. A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation. Cell Cycle. 2005 Mar; 4(3):411-7. PMID: 15684615.
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      51. Thompson T, Tovar C, Yang H, Carvajal D, Vu BT, Xu Q, Wahl G, Heimbrook DC, Vassilev LT. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem. 2004 Dec 17; 279(51):53015-22. PMID: 15471885.
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      52. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl G, Moossa AR, Hoffman RM. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res. 2004 Jun 15; 64(12):4251-6. PMID: 15205338.
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      53. Stommel JM, Wahl G. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J. 2004 Apr 7; 23(7):1547-56. PMID: 15029243.
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      54. Sears J, Kolman J, Wahl G, Aiyar A. Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1. J Virol. 2003 Nov; 77(21):11767-80. PMID: 14557661.
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      55. Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell. 2002 Jun; 1(5):493-503. PMID: 12124178.
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      56. Li Q, Lee JY, Castillo R, Hixon MS, Pujol C, Doppalapudi VR, Shepard HM, Wahl G, Lobl TJ, Chan MF. NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against beta-lactamase-producing strains. Antimicrob Agents Chemother. 2002 May; 46(5):1262-8. PMID: 11959554.
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      57. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl G. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell. 2002 May; 9(5):1031-44. PMID: 12049739.
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      58. Neuteboom ST, Karjian PL, Boyer CR, Beryt M, Pegram M, Wahl G, Shepard HM. Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. Mol Cancer Ther. 2002 Apr; 1(6):377-84. PMID: 12477050.
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      59. Boyer CR, Karjian PL, Wahl G, Pegram M, Neuteboom ST. Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011. Anticancer Drugs. 2002 Jan; 13(1):29-36. PMID: 11914638.
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      60. Aladjem MI, Rodewald LW, Lin CM, Bowman S, Cimbora DM, Brody LL, Epner EM, Groudine M, Wahl G. Replication initiation patterns in the beta-globin loci of totipotent and differentiated murine cells: evidence for multiple initiation regions. Mol Cell Biol. 2002 Jan; 22(2):442-52. PMID: 11756541.
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      61. Wahl G, Carr AM. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol. 2001 Dec; 3(12):E277-86. PMID: 11781586.
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      62. Kanda T, Otter M, Wahl G. Coupling of mitotic chromosome tethering and replication competence in epstein-barr virus-based plasmids. Mol Cell Biol. 2001 May; 21(10):3576-88. PMID: 11313483.
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      63. Kanda T, Otter M, Wahl G. Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering. J Cell Sci. 2001 Jan; 114(Pt 1):49-58. PMID: 11112689.
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      64. Jimenez GS, Nister M, Stommel JM, Beeche M, Barcarse EA, Zhang XQ, O'Gorman S, Wahl G. A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nat Genet. 2000 Sep; 26(1):37-43. PMID: 10973245.
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      65. Khan SH, Moritsugu J, Wahl G. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3266-71. PMID: 10716710.
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      66. Wahl G, Vafa O. Genetic instability, oncogenes, and the p53 pathway. Cold Spring Harb Symp Quant Biol. 2000; 65:511-20. PMID: 12760068.
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      67. Kanda T, Wahl G. The dynamics of acentric chromosomes in cancer cells revealed by GFP-based chromosome labeling strategies. J Cell Biochem Suppl. 2000; Suppl 35:107-14. PMID: 11389539.
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      68. Jimenez GS, Khan SH, Stommel JM, Wahl G. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses. Oncogene. 1999 Dec 13; 18(53):7656-65. PMID: 10618705.
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      69. Fox RI, Herrmann ML, Frangou CG, Wahl G, Morris RE, Strand V, Kirschbaum BJ. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec; 93(3):198-208. PMID: 10600330.
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      70. Fox RI, Herrmann ML, Frangou CG, Wahl G, Morris RE, Kirschbaum BJ. How does leflunomide modulate the immune response in rheumatoid arthritis? BioDrugs. 1999 Oct; 12(4):301-15. PMID: 18031184.
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      71. Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 1999 Aug; 42(Suppl 1):A1-A330. PMID: 27770183.
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      72. Jimenez GS, Bryntesson F, Torres-Arzayus MI, Priestley A, Beeche M, Saito S, Sakaguchi K, Appella E, Jeggo PA, Taccioli GE, Wahl G, Hubank M. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature. 1999 Jul 1; 400(6739):81-3. PMID: 10403253.
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      73. Stommel JM, Marchenko ND, Jimenez GS, Moll UM, Hope TJ, Wahl G. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 1999 Mar 15; 18(6):1660-72. PMID: 10075936.
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      74. Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl G, Tlsty TD, Chiu CP. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet. 1999 Jan; 21(1):111-4. PMID: 9916802.
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      75. Jiang W, Jimenez G, Wells NJ, Hope TJ, Wahl G, Hunter T, Fukunaga R. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec; 2(6):877-85. PMID: 9885575.
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      76. Aladjem MI, Rodewald LW, Kolman JL, Wahl G. Genetic dissection of a mammalian replicator in the human beta-globin locus. Science. 1998 Aug 14; 281(5379):1005-9. PMID: 9703500.
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      77. Paulson TG, Almasan A, Brody LL, Wahl G. Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. Mol Cell Biol. 1998 May; 18(5):3089-100. PMID: 9566927.
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      78. Kanda T, Sullivan KF, Wahl G. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol. 1998 Mar 26; 8(7):377-85. PMID: 9545195.
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      79. Shimizu N, Itoh N, Utiyama H, Wahl G. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol. 1998 Mar 23; 140(6):1307-20. PMID: 9508765.
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      80. Khan SH, Wahl G. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res. 1998 Feb 1; 58(3):396-401. PMID: 9458079.
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      81. Aladjem MI, Spike BT, Rodewald LW, Hope TJ, Klemm M, Jaenisch R, Wahl G. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol. 1998 Jan 29; 8(3):145-55. PMID: 9443911.
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      82. Aladjem MI, Wahl G. Mapping replication fork direction by leading strand analysis. Methods. 1997 Nov; 13(3):281-92. PMID: 9441854.
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      83. O'Gorman S, Wahl G. Mouse engineering. Science. 1997 Aug 22; 277(5329):1025. PMID: 9289845.
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      84. Brown M, Parker D, Seeland E, Boyle D, Wahl G. Five years of work-related injuries and fatalities in Minnesota. Agriculture: a high-risk industry. Minn Med. 1997 Aug; 80(8):29-32. PMID: 9265823.
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      85. Linke SP, Harris MP, Neugebauer SE, Clarkin KC, Shepard HM, Maneval DC, Wahl G. p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression. Oncogene. 1997 Jul 17; 15(3):337-45. PMID: 9233768.
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      86. Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl G. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res. 1997 Mar 15; 57(6):1013-9. PMID: 9067261.
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      87. Linke SP, Clarkin KC, Wahl G. p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation. Cancer Res. 1997 Mar 15; 57(6):1171-9. PMID: 9067289.
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      88. Aladjem MI, Brody LL, O'Gorman S, Wahl G. Positive selection of FLP-mediated unequal sister chromatid exchange products in mammalian cells. Mol Cell Biol. 1997 Feb; 17(2):857-61. PMID: 9001240.
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      89. Wahl G, Linke SP, Paulson TG, Huang LC. Maintaining genetic stability through TP53 mediated checkpoint control. Cancer Surv. 1997; 29:183-219. PMID: 9338102.
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      90. Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl G, Bradley A. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14106-11. PMID: 8943068.
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      91. Paulson TG, Wright FA, Parker BA, Russack V, Wahl G. Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer. Cancer Res. 1996 Sep 1; 56(17):4021-6. PMID: 8752173.
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      92. Huang LC, Clarkin KC, Wahl G. p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res. 1996 Jul 1; 56(13):2940-4. PMID: 8674045.
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      93. Huang LC, Clarkin KC, Wahl G. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4827-32. PMID: 8643488.
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      94. Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl G. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 1996 Apr 15; 10(8):934-47. PMID: 8608941.
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      95. Shimizu N, Kanda T, Wahl G. Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. Nat Genet. 1996 Jan; 12(1):65-71. PMID: 8528254.
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      96. Aladjem MI, Groudine M, Brody LL, Dieken ES, Fournier RE, Wahl G, Epner EM. Participation of the human beta-globin locus control region in initiation of DNA replication. Science. 1995 Nov 3; 270(5237):815-9. PMID: 7481774.
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      97. Li W, Fan J, Hochhauser D, Banerjee D, Zielinski Z, Almasan A, Yin Y, Kelly R, Wahl G, Bertino JR. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10436-40. PMID: 7479800.
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      98. Kelly RE, DeRose ML, Draper BW, Wahl G. Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene. Mol Cell Biol. 1995 Aug; 15(8):4136-48. PMID: 7623808.
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      99. Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, Bertino JR, Wahl G. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A. 1995 Jun 6; 92(12):5436-40. PMID: 7777526.
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      100. Almasan A, Linke SP, Paulson TG, Huang LC, Wahl G. Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Cancer Metastasis Rev. 1995 Mar; 14(1):59-73. PMID: 7606822.
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      101. Di Leonardo A, Linke SP, Clarkin K, Wahl G. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 1994 Nov 1; 8(21):2540-51. PMID: 7958916.
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      102. Van den Berg CL, McGill JR, Kuhn JG, Walsh JT, De La Cruz PS, Davidson KK, Wahl G, Von Hoff DD. Pharmacokinetics of hydroxyurea in nude mice. Anticancer Drugs. 1994 Oct; 5(5):573-8. PMID: 7858290.
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      103. Eckhardt SG, Dai A, Davidson KK, Forseth BJ, Wahl G, Von Hoff DD. Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. Proc Natl Acad Sci U S A. 1994 Jul 5; 91(14):6674-8. PMID: 8022834; PMCID: PMC44265.
      104. Almasan A, Mangelsdorf DJ, Ong ES, Wahl G, Evans RM. Chromosomal localization of the human retinoid X receptors. Genomics. 1994 Apr; 20(3):397-403. PMID: 8034312.
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      105. Carroll SM, DeRose ML, Kolman JL, Nonet GH, Kelly RE, Wahl G. Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci. Mol Cell Biol. 1993 May; 13(5):2971-81. PMID: 8474455.
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      106. Nonet GH, Wahl G. Introduction of YACs containing a putative mammalian replication origin into mammalian cells can generate structures that replicate autonomously. Somat Cell Mol Genet. 1993 Mar; 19(2):171-92. PMID: 8511674.
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      107. Nonet GH, Carroll SM, DeRose ML, Wahl G. Molecular dissection of an extrachromosomal amplicon reveals a circular structure consisting of an imperfect inverted duplication. Genomics. 1993 Mar; 15(3):543-58. PMID: 8468049.
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      108. Barclay BJ, Ondrusek NK, Wildenhain YD, Huang T, Carlone RL, Clement JM, Wahl G. Effect of genomic position on amplification of the DFR1 gene in Saccharomyces cerevisiae. Adv Exp Med Biol. 1993; 338:545-50. PMID: 8304177.
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      109. Di Leonardo A, Linke SP, Yin Y, Wahl G. Cell cycle regulation of gene amplification. Cold Spring Harb Symp Quant Biol. 1993; 58:655-67. PMID: 7956082.
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      110. Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl G. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell. 1992 Sep 18; 70(6):937-48. PMID: 1525830.
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      111. Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, Van Devanter DR, Wahl G. Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci U S A. 1992 Sep 1; 89(17):8165-9. PMID: 1518843.
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      112. Windle BE, Wahl G. Molecular dissection of mammalian gene amplification: new mechanistic insights revealed by analyses of very early events. Mutat Res. 1992 May; 276(3):199-224. PMID: 1374515.
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      113. Haughey BH, von Hoff DD, Windle BE, Wahl G, Mock PM. c-myc oncogene copy number in squamous carcinoma of the head and neck. Am J Otolaryngol. 1992 May-Jun; 13(3):168-71. PMID: 1626617.
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      114. Kimmel M, Axelrod DE, Wahl G. A branching process model of gene amplification following chromosome breakage. Mutat Res. 1992 May; 276(3):225-39. PMID: 1374516.
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      115. Von Hoff DD, Waddelow T, Forseth B, Davidson K, Scott J, Wahl G. Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells. Cancer Res. 1991 Dec 1; 51(23 Pt 1):6273-9. PMID: 1682044.
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      116. Carroll SM, Trotter J, Wahl G. Replication timing control can be maintained in extrachromosomally amplified genes. Mol Cell Biol. 1991 Sep; 11(9):4779-85. PMID: 1678857.
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      117. O'Gorman S, Fox DT, Wahl G. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science. 1991 Mar 15; 251(4999):1351-5. PMID: 1900642.
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      118. Benner SE, Wahl G, Von Hoff DD. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs. 1991 Feb; 2(1):11-25. PMID: 1720337.
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      119. Windle B, Draper BW, Yin YX, O'Gorman S, Wahl G. A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev. 1991 Feb; 5(2):160-74. PMID: 1995414.
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      120. Ruiz JC, Wahl G. Chromosomal destabilization during gene amplification. Mol Cell Biol. 1990 Jun; 10(6):3056-66. PMID: 2188107.
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      121. Barringer KJ, Orgel L, Wahl G, Gingeras TR. Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplification scheme. Gene. 1990 Apr 30; 89(1):117-22. PMID: 2197176.
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      122. Stark GR, Debatisse M, Giulotto E, Wahl G. Recent progress in understanding mechanisms of mammalian DNA amplification. Cell. 1989 Jun 16; 57(6):901-8. PMID: 2661014.
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      123. Wahl G. The importance of circular DNA in mammalian gene amplification. Cancer Res. 1989 Mar 15; 49(6):1333-40. PMID: 2647287.
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      124. Ruiz JC, Choi KH, von Hoff DD, Roninson IB, Wahl G. Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. Mol Cell Biol. 1989 Jan; 9(1):109-15. PMID: 2648129.
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      125. Ruiz JC, Wahl G. Formation of an inverted duplication can be an initial step in gene amplification. Mol Cell Biol. 1988 Oct; 8(10):4302-13. PMID: 3185551.
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      126. Von Hoff DD, Needham-VanDevanter DR, Yucel J, Windle BE, Wahl G. Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4804-8. PMID: 3164477.
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      127. Carroll SM, DeRose ML, Gaudray P, Moore CM, Needham-Vandevanter DR, Von Hoff DD, Wahl G. Double minute chromosomes can be produced from precursors derived from a chromosomal deletion. Mol Cell Biol. 1988 Apr; 8(4):1525-33. PMID: 2898098.
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      128. Carroll SM, Gaudray P, De Rose ML, Emery JF, Meinkoth JL, Nakkim E, Subler M, Von Hoff DD, Wahl G. Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol Cell Biol. 1987 May; 7(5):1740-50. PMID: 2885742.
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      129. Meinkoth J, Killary AM, Fournier RE, Wahl G. Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. Mol Cell Biol. 1987 Apr; 7(4):1415-24. PMID: 3600632.
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      130. Ruiz JC, Wahl G. Escherichia coli aspartate transcarbamylase: a novel marker for studies of gene amplification and expression in mammalian cells. Mol Cell Biol. 1986 Sep; 6(9):3050-8. PMID: 3537729.
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      131. Meinkoth JL, Legouy E, Brison O, Wahl G. New RNA species is produced by alternate polyadenylation following rearrangement associated with CAD gene amplification. Somat Cell Mol Genet. 1986 Jul; 12(4):339-50. PMID: 2426798.
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      132. Gaudray P, Trotter J, Wahl G. Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase. J Biol Chem. 1986 May 15; 261(14):6285-92. PMID: 3700393.
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      133. Wahl G, Robert de Saint Vincent B, DeRose ML. Effect of chromosomal position on amplification of transfected genes in animal cells. Nature. 1984 Feb 9-15; 307(5951):516-20. PMID: 6694743.
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      134. Stark GR, Wahl G. Gene amplification. Annu Rev Biochem. 1984; 53:447-91. PMID: 6383198.
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      135. Wahl G, Vitto L, Rubnitz J. Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells. Mol Cell Biol. 1983 Nov; 3(11):2066-75. PMID: 6318080.
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      136. Chu BC, Wahl G, Orgel LE. Derivatization of unprotected polynucleotides. Nucleic Acids Res. 1983 Sep 24; 11(18):6513-29. PMID: 6622259.
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      137. Folger KR, Wong EA, Wahl G, Capecchi MR. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol. 1982 Nov; 2(11):1372-87. PMID: 6298598.
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      138. Padgett RA, Wahl G, Stark GR. Properties of dispersed, highly repeated DNA within and near the hamster CAD gene. Mol Cell Biol. 1982 Mar; 2(3):302-7. PMID: 6180303.
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      139. Wahl G, Vitto L, Padgett RA, Stark GR. Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Mol Cell Biol. 1982 Mar; 2(3):308-19. PMID: 6180304.
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      140. Padgett RA, Wahl G, Stark GR. Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. Mol Cell Biol. 1982 Mar; 2(3):293-301. PMID: 6125880.
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      141. de Saint Vincent BR, Delbrück S, Eckhart W, Meinkoth J, Vitto L, Wahl G. The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker. Cell. 1981 Dec; 27(2 Pt 1):267-77. PMID: 6277500.
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      142. Wahl G, Padgett RA, Stark GR. Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells. J Biol Chem. 1979 Sep 10; 254(17):8679-89. PMID: 381311.
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      143. Padgett RA, Wahl G, Coleman PF, Stark GR. N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. J Biol Chem. 1979 Feb 10; 254(3):974-80. PMID: 762107.
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      144. Alwine JC, Kemp DJ, Parker BA, Reiser J, Renart J, Stark GR, Wahl G. Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods Enzymol. 1979; 68:220-42. PMID: 94421.
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      145. Capecchi MR, Hughes SH, Wahl G. Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell. 1975 Nov; 6(3):269-77. PMID: 802681.
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      146. Wahl G, Hughes SH, Capecchi MR. Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol. 1975 Apr; 85(2 Pt 1):307-20. PMID: 47331.
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