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The molecular chronology of mammary epithelial cell fate switching. bioRxiv. 2024 Nov 04.
Vallmajo-Martin Q, Ma Z, Srinivasan S, Murali D, Dravis C, Mukund K, Subramaniam S, Wahl GM, Lytle NK. PMID: 39415993; PMCID: PMC11482796.
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LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment. bioRxiv. 2024 Apr 23.
Reina J, Vallmajo-Martin Q, Ning J, Michi AN, Yeung K, Wahl GM, Hunter T. PMID: 38712081; PMCID: PMC11071390.
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PubMed Mentions:
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Cancer as a Disease of Development Gone Awry. Annu Rev Pathol. 2024 Jan 24; 19:397-421.
Stanger BZ, Wahl GM. PMID: 37832945; PMCID: PMC11486542.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth. Nat Cell Biol. 2023 Jan; 25(1):159-169.
Tang R, Shuldiner EG, Kelly M, Murray CW, Hebert JD, Andrejka L, Tsai MK, Hughes NW, Parker MI, Cai H, Li YC, Wahl GM, Dunbrack RL, Jackson PK, Petrov DA, Winslow MM. PMID: 36635501; PMCID: PMC10521195.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Structural variants drive context-dependent oncogene activation in cancer. Nature. 2022 12; 612(7940):564-572.
Xu Z, Lee DS, Chandran S, Le VT, Bump R, Yasis J, Dallarda S, Marcotte S, Clock B, Haghani N, Cho CY, Akdemir KC, Tyndale S, Futreal PA, McVicker G, Wahl GM, Dixon JR. PMID: 36477537; PMCID: PMC9810360.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer. Cancer Discov. 2022 12 02; 12(12):2930-2953.
Langille E, Al-Zahrani KN, Ma Z, Liang M, Uuskula-Reimand L, Espin R, Teng K, Malik A, Bergholtz H, Ghamrasni SE, Afiuni-Zadeh S, Tsai R, Alvi S, Elia A, Lü Y, Oh RH, Kozma KJ, Trcka D, Narimatsu M, Liu JC, Nguyen T, Barutcu S, Loganathan SK, Bremner R, Bader GD, Egan SE, Cescon DW, Sørlie T, Wrana JL, Jackson HW, Wilson MD, Witkiewicz AK, Knudsen ES, Pujana MA, Wahl GM, Schramek D. PMID: 36108220; PMCID: PMC9812400.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Eicosanoids in the pancreatic tumor microenvironment - a multicellular, multifaceted progression. Gastro Hep Adv. 2022; 1(4):682-697.
Gubbala VB, Jytosana N, Trinh VQ, Maurer HC, Naeem RF, Lytle NK, Ma Z, Zhao S, Lin W, Han H, Shi Y, Hunter T, Singh PK, Olive KP, Tan MCB, Kaech SM, Wahl GM, DelGiorno KE. PMID: 36277993; PMCID: PMC9583893.
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PubMed Mentions:
3
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Single-Cell Transcriptomic and Epigenetic Analyses of Mouse Mammary Development Starting with the Embryo. Methods Mol Biol. 2022; 2471:49-82.
Ma Z, Lytle NK, Ramos C, Naeem RF, Wahl GM. PMID: 35175591; PMCID: PMC9663269.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2021 Dec; 600(7889):E18.
Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 34848876.
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PubMed Mentions:
2 Fields:
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Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury. Gastroenterology. 2022 02; 162(2):604-620.e20.
Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Arrojo E Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, DelGiorno KE. PMID: 34695382; PMCID: PMC8792222.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. Gastroenterology. 2020 11; 159(5):1866-1881.e8.
DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM. PMID: 32717220; PMCID: PMC7680354.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
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Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. Cell Rep. 2020 06 09; 31(10):107742.
Christin JR, Wang C, Chung CY, Liu Y, Dravis C, Tang W, Oktay MH, Wahl GM, Guo W. PMID: 32521267; PMCID: PMC7658810.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12121-12130.
Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. PMID: 32424096; PMCID: PMC7275768.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020 04 03; 368(6486):85-89.
Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. PMID: 32241947; PMCID: PMC7681911.
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PubMed Mentions:
478 Fields:
Translation:
HumansAnimalsCells
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Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis. Front Physiol. 2020; 11:88.
DelGiorno KE, Naeem RF, Fang L, Chung CY, Ramos C, Luhtala N, O'Connor C, Hunter T, Manor U, Wahl GM. PMID: 32116793; PMCID: PMC7033634.
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PubMed Mentions:
23
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Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Sci Alliance. 2020 01; 3(1).
Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW. PMID: 31959624; PMCID: PMC6971368.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. Cell Rep. 2019 12 10; 29(11):3448-3459.e6.
Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC. PMID: 31825828; PMCID: PMC6948147.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships. Cell Rep. 2019 10 08; 29(2):495-510.e6.
Chung CY, Ma Z, Dravis C, Preissl S, Poirion O, Luna G, Hou X, Giraddi RR, Ren B, Wahl GM. PMID: 31597106; PMCID: PMC6887110.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 05; 569(7754):131-135.
Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 30996350; PMCID: PMC6565370.
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PubMed Mentions:
171 Fields:
Translation:
HumansAnimalsCells
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Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell. 2018 09 10; 34(3):466-482.e6.
Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. PMID: 30174241; PMCID: PMC6152943.
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PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
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Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development. Cell Rep. 2018 08 07; 24(6):1653-1666.e7.
Giraddi RR, Chung CY, Heinz RE, Balcioglu O, Novotny M, Trejo CL, Dravis C, Hagos BM, Mehrabad EM, Rodewald LW, Hwang JY, Fan C, Lasken R, Varley KE, Perou CM, Wahl GM, Spike BT. PMID: 30089273; PMCID: PMC6301014.
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PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051.
Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM. PMID: 29211796; PMCID: PMC5718507.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. NPJ Breast Cancer. 2017; 3:16.
Trejo CL, Luna G, Dravis C, Spike BT, Wahl GM. PMID: 28649656; PMCID: PMC5460261.
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PubMed Mentions:
17
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Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer. 2017; 3:14.
Wahl GM, Spike BT. PMID: 28649654; PMCID: PMC5460241.
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PubMed Mentions:
78
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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125.
Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237; PMCID: PMC5334176.
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PubMed Mentions:
346 Fields:
Translation:
HumansCells
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[Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Aug 18; 48(4):697-701.
Wang Y, Barry O, Wahl G, Chen B, Lin Y. PMID: 29263516.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743.
Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte JC. PMID: 26899176; PMCID: PMC4764898.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep. 2015 Sep 29; 12(12):2035-48.
Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM. PMID: 26365194; PMCID: PMC4591253.
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PubMed Mentions:
64 Fields:
Translation:
HumansAnimalsCells
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The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 09; 55(9):1387-96.
Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. PMID: 26310697; PMCID: PMC4891300.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila). 2015 Sep; 8(9):762-4.
Rozhok AI, Wahl GM, DeGregori J. PMID: 26122457; PMCID: PMC4849411.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat. 2015 Jan; 149(2):425-37.
Pfefferle AD, Spike BT, Wahl GM, Perou CM. PMID: 25575446; PMCID: PMC4308649.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11; 9(5):1946-1958.
Li YC, Rodewald LW, Hoppmann C, Wong ET, Lebreton S, Safar P, Patek M, Wang L, Wertman KF, Wahl GM. PMID: 25464845; PMCID: PMC4269221.
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PubMed Mentions:
43 Fields:
Translation:
HumansCells
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Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93.
Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. PMID: 25259922; PMCID: PMC4177038.
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PubMed Mentions:
532 Fields:
Translation:
HumansAnimalsCells
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CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports. 2014 Apr 08; 2(4):427-39.
Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl GM, Gray PC. PMID: 24749068; PMCID: PMC3986630.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013 Nov 12; 14(11):R125.
Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. PMID: 24220145; PMCID: PMC4053990.
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PubMed Mentions:
144 Fields:
Translation:
HumansAnimalsCells
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AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol. 2014 Jan; 34(2):148-57.
He G, Zhang YW, Lee JH, Zeng SX, Wang YV, Luo Z, Dong XC, Viollet B, Wahl GM, Lu H. PMID: 24190973; PMCID: PMC3911293.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem. 2013 Sep 06; 288(36):26301-26310.
Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl GM, Rathmell WK. PMID: 23893409; PMCID: PMC3764835.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia. 2013 Jun; 18(2):209-19.
Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM, Eaves CJ. PMID: 23624881; PMCID: PMC4161372.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6991-6.
Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl GM. PMID: 23559372; PMCID: PMC3637696.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. PLoS One. 2013; 8(3):e58395.
Green JL, Bauer M, Yum KW, Li YC, Cox ML, Willert K, Wahl GM. PMID: 23516471; PMCID: PMC3596392.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 2013 Feb; 13(2):83-96.
Wade M, Li YC, Wahl GM. PMID: 23303139; PMCID: PMC4161369.
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PubMed Mentions:
593 Fields:
Translation:
HumansAnimals
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What a difference a phosphate makes: life or death decided by a single amino acid in MDM2. Cancer Cell. 2012 May 15; 21(5):595-596.
Li YC, Wahl GM. PMID: 22624708.
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PubMed Mentions:
1 Fields:
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Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein. J Biol Chem. 2012 Jun 15; 287(25):20898-903.
Lee JH, Jin Y, He G, Zeng SX, Wang YV, Wahl GM, Lu H. PMID: 22556425; PMCID: PMC3375513.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell. 2012 Feb 03; 10(2):183-97.
Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM. PMID: 22305568; PMCID: PMC3277444.
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PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells
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Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene. 2012 Nov 08; 31(45):4789-97.
Wade M, Li YC, Matani AS, Braun SM, Milanesi F, Rodewald LW, Wahl GM. PMID: 22266850; PMCID: PMC3337965.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38.
Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. PMID: 21724834; PMCID: PMC3134085.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer. 2011 Apr; 2(4):404-19.
Spike BT, Wahl GM. PMID: 21779509; PMCID: PMC3135646.
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PubMed Mentions:
86
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Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22745-50.
Mizuno H, Spike BT, Wahl GM, Levine AJ. PMID: 21149740; PMCID: PMC3012457.
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PubMed Mentions:
94 Fields:
Translation:
HumansCells
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A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16; 18(5):411-22.
Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. PMID: 21075307; PMCID: PMC3050021.
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PubMed Mentions:
136 Fields:
Translation:
HumansAnimalsCells
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The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol. 2010 May; 20(5):299-309.
Wade M, Wang YV, Wahl GM. PMID: 20172729; PMCID: PMC2910097.
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PubMed Mentions:
246 Fields:
Translation:
HumansAnimalsCells
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Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo. Cell Cycle. 2009 Nov 01; 8(21):3443-4.
Wang YV, Wade M, Wahl GM. PMID: 19838055; PMCID: PMC2777705.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol. 2009 Oct; 219(2):263-74.
Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl GM, Nister M, Weinberg WC. PMID: 19718706; PMCID: PMC4208754.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009 Aug 27; 460(7259):1140-4.
Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Izpisúa Belmonte JC. PMID: 19668186; PMCID: PMC2735889.
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PubMed Mentions:
590 Fields:
Translation:
HumansAnimalsCells
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Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell. 2009 Jul 07; 16(1):33-43.
Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. PMID: 19573810; PMCID: PMC2758524.
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PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
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Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res. 2009 Jan; 7(1):1-11.
Wade M, Wahl GM. PMID: 19147532; PMCID: PMC2629357.
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PubMed Mentions:
86 Fields:
Translation:
HumansAnimalsCells
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BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle. 2008 Jul 01; 7(13):1973-82.
Wade M, Rodewald LW, Espinosa JM, Wahl GM. PMID: 18604177; PMCID: PMC2625302.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12365-70.
Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. PMID: 17640893; PMCID: PMC1941475.
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PubMed Mentions:
70 Fields:
Translation:
HumansCells
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MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Int J Biochem Cell Biol. 2007; 39(7-8):1476-82.
Toledo F, Wahl GM. PMID: 17499002; PMCID: PMC2043116.
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PubMed Mentions:
104 Fields:
Translation:
HumansCells
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Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 2007 Feb; 27(4):1425-32.
Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM. PMID: 17158931; PMCID: PMC1800716.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer. 2006 Dec; 6(12):909-23.
Toledo F, Wahl GM. PMID: 17128209.
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PubMed Mentions:
600 Fields:
Translation:
HumansAnimalsCells
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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006 Oct 01; 66(19):9339-44.
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. PMID: 16990346.
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PubMed Mentions:
1350 Fields:
Translation:
HumansAnimalsCells
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Hdmx modulates the outcome of p53 activation in human tumor cells. J Biol Chem. 2006 Nov 03; 281(44):33036-44.
Wade M, Wong ET, Tang M, Stommel JM, Wahl GM. PMID: 16905769.
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PubMed Mentions:
77 Fields:
Translation:
HumansCells
-
RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic Acids Res. 2006 Jul 26; 34(13):e92.
Toledo F, Liu CW, Lee CJ, Wahl GM. PMID: 16870721; PMCID: PMC1540739.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo. Cell Death Differ. 2006 Jun; 13(6):973-83.
Wahl GM. PMID: 16575406.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 2006 Jun; 13(6):927-34.
Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. PMID: 16543935.
View in:
PubMed Mentions:
165 Fields:
Translation:
HumansAnimalsCells
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Explaining the biological activity of transactivation-deficient p53 variants. Nat Genet. 2006 Apr; 38(4):395-6; author reply 396-7.
Tang M, Wahl GM, Nistér M. PMID: 16570054.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell. 2006 Apr; 9(4):273-85.
Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM. PMID: 16616333.
View in:
PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
-
c-Myc, genome instability, and tumorigenesis: the devil is in the details. Curr Top Microbiol Immunol. 2006; 302:169-203.
Wade M, Wahl GM. PMID: 16620029.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res. 2005 Oct 04; 33(17):e147.
Wong ET, Kolman JL, Li YC, Mesner LD, Hillen W, Berens C, Wahl GM. PMID: 16204450; PMCID: PMC1243804.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Initiation of DNA replication at the human beta-globin 3' enhancer. Nucleic Acids Res. 2005; 33(14):4412-24.
Buzina A, Aladjem MI, Kolman JL, Wahl GM, Ellis J. PMID: 16085752; PMCID: PMC1183104.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10188-93.
Krummel KA, Lee CJ, Toledo F, Wahl GM. PMID: 16006521; PMCID: PMC1177381.
View in:
PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
-
p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene. 2005 May 19; 24(22):3563-73.
Nistér M, Tang M, Zhang XQ, Yin C, Beeche M, Hu X, Enblad G, van Dyke T, Wahl GM. PMID: 15750633.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation. Cell Cycle. 2005 Mar; 4(3):411-7.
Stommel JM, Wahl GM. PMID: 15684615.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem. 2004 Dec 17; 279(51):53015-22.
Thompson T, Tovar C, Yang H, Carvajal D, Vu BT, Xu Q, Wahl GM, Heimbrook DC, Vassilev LT. PMID: 15471885.
View in:
PubMed Mentions:
93 Fields:
Translation:
HumansCells
-
Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res. 2004 Jun 15; 64(12):4251-6.
Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR, Hoffman RM. PMID: 15205338.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J. 2004 Apr 07; 23(7):1547-56.
Stommel JM, Wahl GM. PMID: 15029243; PMCID: PMC391059.
View in:
PubMed Mentions:
166 Fields:
Translation:
HumansAnimalsCells
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Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1. J Virol. 2003 Nov; 77(21):11767-80.
Sears J, Kolman J, Wahl GM, Aiyar A. PMID: 14557661; PMCID: PMC229350.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansCells
-
p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell. 2002 Jun; 1(5):493-503.
Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. PMID: 12124178.
View in:
PubMed Mentions:
117 Fields:
Translation:
AnimalsCells
-
NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against beta-lactamase-producing strains. Antimicrob Agents Chemother. 2002 May; 46(5):1262-8.
Li Q, Lee JY, Castillo R, Hixon MS, Pujol C, Doppalapudi VR, Shepard HM, Wahl GM, Lobl TJ, Chan MF. PMID: 11959554; PMCID: PMC127132.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell. 2002 May; 9(5):1031-44.
Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM. PMID: 12049739.
View in:
PubMed Mentions:
401 Fields:
Translation:
HumansCells
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Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. Mol Cancer Ther. 2002 Apr; 1(6):377-84.
Neuteboom ST, Karjian PL, Boyer CR, Beryt M, Pegram M, Wahl GM, Shepard HM. PMID: 12477050.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011. Anticancer Drugs. 2002 Jan; 13(1):29-36.
Boyer CR, Karjian PL, Wahl GM, Pegram M, Neuteboom ST. PMID: 11914638.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
Replication initiation patterns in the beta-globin loci of totipotent and differentiated murine cells: evidence for multiple initiation regions. Mol Cell Biol. 2002 Jan; 22(2):442-52.
Aladjem MI, Rodewald LW, Lin CM, Bowman S, Cimbora DM, Brody LL, Epner EM, Groudine M, Wahl GM. PMID: 11756541; PMCID: PMC139749.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol. 2001 Dec; 3(12):E277-86.
Wahl GM, Carr AM. PMID: 11781586.
View in:
PubMed Mentions:
92 Fields:
Translation:
Animals
-
Coupling of mitotic chromosome tethering and replication competence in epstein-barr virus-based plasmids. Mol Cell Biol. 2001 May; 21(10):3576-88.
Kanda T, Otter M, Wahl GM. PMID: 11313483; PMCID: PMC100279.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering. J Cell Sci. 2001 Jan; 114(Pt 1):49-58.
Kanda T, Otter M, Wahl GM. PMID: 11112689.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansCells
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A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nat Genet. 2000 Sep; 26(1):37-43.
Jimenez GS, Nister M, Stommel JM, Beeche M, Barcarse EA, Zhang XQ, O'Gorman S, Wahl GM. PMID: 10973245.
View in:
PubMed Mentions:
55 Fields:
Translation:
Animals
-
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3266-71.
Khan SH, Moritsugu J, Wahl GM. PMID: 10716710; PMCID: PMC16227.
View in:
PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
-
The dynamics of acentric chromosomes in cancer cells revealed by GFP-based chromosome labeling strategies. J Cell Biochem Suppl. 2000; Suppl 35:107-14.
Kanda T, Wahl GM. PMID: 11389539.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Genetic instability, oncogenes, and the p53 pathway. Cold Spring Harb Symp Quant Biol. 2000; 65:511-20.
Wahl G, Vafa O. PMID: 12760068.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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p53 regulation by post-translational modification and nuclear retention in response to diverse stresses. Oncogene. 1999 Dec 13; 18(53):7656-65.
Jimenez GS, Khan SH, Stommel JM, Wahl GM. PMID: 10618705.
View in:
PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec; 93(3):198-208.
Fox RI, Herrmann ML, Frangou CG, Wahl GM, Morris RE, Strand V, Kirschbaum BJ. PMID: 10600330.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansAnimals
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How does leflunomide modulate the immune response in rheumatoid arthritis? BioDrugs. 1999 Oct; 12(4):301-15.
Fox RI, Herrmann ML, Frangou CG, Wahl GM, Morris RE, Kirschbaum BJ. PMID: 18031184.
View in:
PubMed Mentions:
7 Fields:
-
DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature. 1999 Jul 01; 400(6739):81-3.
Jimenez GS, Bryntesson F, Torres-Arzayus MI, Priestley A, Beeche M, Saito S, Sakaguchi K, Appella E, Jeggo PA, Taccioli GE, Wahl GM, Hubank M. PMID: 10403253.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 1999 Mar 15; 18(6):1660-72.
Stommel JM, Marchenko ND, Jimenez GS, Moll UM, Hope TJ, Wahl GM. PMID: 10075936; PMCID: PMC1171253.
View in:
PubMed Mentions:
251 Fields:
Translation:
HumansAnimalsCells
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Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet. 1999 Jan; 21(1):111-4.
Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP. PMID: 9916802.
View in:
PubMed Mentions:
171 Fields:
Translation:
HumansCells
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PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec; 2(6):877-85.
Jiang W, Jimenez G, Wells NJ, Hope TJ, Wahl GM, Hunter T, Fukunaga R. PMID: 9885575.
View in:
PubMed Mentions:
167 Fields:
Translation:
HumansCells
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Genetic dissection of a mammalian replicator in the human beta-globin locus. Science. 1998 Aug 14; 281(5379):1005-9.
Aladjem MI, Rodewald LW, Kolman JL, Wahl GM. PMID: 9703500.
View in:
PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. Mol Cell Biol. 1998 May; 18(5):3089-100.
Paulson TG, Almasan A, Brody LL, Wahl GM. PMID: 9566927; PMCID: PMC110691.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansCells
-
Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol. 1998 Mar 26; 8(7):377-85.
Kanda T, Sullivan KF, Wahl GM. PMID: 9545195.
View in:
PubMed Mentions:
424 Fields:
Translation:
HumansAnimalsCells
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Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol. 1998 Mar 23; 140(6):1307-20.
Shimizu N, Itoh N, Utiyama H, Wahl GM. PMID: 9508765; PMCID: PMC2132668.
View in:
PubMed Mentions:
83 Fields:
Translation:
HumansCells
-
p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res. 1998 Feb 01; 58(3):396-401.
Khan SH, Wahl GM. PMID: 9458079.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansCells
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ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol. 1998 Jan 29; 8(3):145-55.
Aladjem MI, Spike BT, Rodewald LW, Hope TJ, Klemm M, Jaenisch R, Wahl GM. PMID: 9443911.
View in:
PubMed Mentions:
182 Fields:
Translation:
HumansCells
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Mapping replication fork direction by leading strand analysis. Methods. 1997 Nov; 13(3):281-92.
Aladjem MI, Wahl GM. PMID: 9441854.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Mouse engineering. Science. 1997 Aug 22; 277(5329):1025.
O'Gorman S, Wahl GM. PMID: 9289845.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Five years of work-related injuries and fatalities in Minnesota. Agriculture: a high-risk industry. Minn Med. 1997 Aug; 80(8):29-32.
Brown M, Parker D, Seeland E, Boyle D, Wahl G. PMID: 9265823.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansPHPublic Health
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p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression. Oncogene. 1997 Jul 17; 15(3):337-45.
Linke SP, Harris MP, Neugebauer SE, Clarkin KC, Shepard HM, Maneval DC, Wahl GM. PMID: 9233768.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Detection of Loa loa-specific DNA in blood from occult-infected individuals. Exp Parasitol. 1997 Jul; 86(3):163-70.
Touré FS, Bain O, Nerrienet E, Millet P, Wahl G, Toure Y, Doumbo O, Nicolas L, Georges AJ, McReynolds LA, Egwang TG. PMID: 9225766.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation. Cancer Res. 1997 Mar 15; 57(6):1171-9.
Linke SP, Clarkin KC, Wahl GM. PMID: 9067289.
View in:
PubMed Mentions:
27 Fields:
Translation:
Cells
-
DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res. 1997 Mar 15; 57(6):1013-9.
Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. PMID: 9067261.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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Positive selection of FLP-mediated unequal sister chromatid exchange products in mammalian cells. Mol Cell Biol. 1997 Feb; 17(2):857-61.
Aladjem MI, Brody LL, O'Gorman S, Wahl GM. PMID: 9001240; PMCID: PMC231812.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Species-specific sequence in the repeat 3 region of the gene encoding a putative Loa loa allergen: a diagnostic tool for occult loiasis. Am J Trop Med Hyg. 1997 Jan; 56(1):57-60.
Toure FS, Egwang TG, Wahl G, Millet P, Bain O, Georges AJ. PMID: 9063362.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Maintaining genetic stability through TP53 mediated checkpoint control. Cancer Surv. 1997; 29:183-219.
Wahl GM, Linke SP, Paulson TG, Huang LC. PMID: 9338102.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14106-11.
Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl GM, Bradley A. PMID: 8943068; PMCID: PMC19502.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer. Cancer Res. 1996 Sep 01; 56(17):4021-6.
Paulson TG, Wright FA, Parker BA, Russack V, Wahl GM. PMID: 8752173.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res. 1996 Jul 01; 56(13):2940-4.
Huang LC, Clarkin KC, Wahl GM. PMID: 8674045.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4827-32.
Huang LC, Clarkin KC, Wahl GM. PMID: 8643488; PMCID: PMC39364.
View in:
PubMed Mentions:
103 Fields:
Translation:
HumansCells
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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 1996 Apr 15; 10(8):934-47.
Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM. PMID: 8608941.
View in:
PubMed Mentions:
147 Fields:
Translation:
HumansCells
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Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. Nat Genet. 1996 Jan; 12(1):65-71.
Shimizu N, Kanda T, Wahl GM. PMID: 8528254.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Participation of the human beta-globin locus control region in initiation of DNA replication. Science. 1995 Nov 03; 270(5237):815-9.
Aladjem MI, Groudine M, Brody LL, Dieken ES, Fournier RE, Wahl GM, Epner EM. PMID: 7481774.
View in:
PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10436-40.
Li W, Fan J, Hochhauser D, Banerjee D, Zielinski Z, Almasan A, Yin Y, Kelly R, Wahl GM, Bertino JR. PMID: 7479800; PMCID: PMC40812.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene. Mol Cell Biol. 1995 Aug; 15(8):4136-48.
Kelly RE, DeRose ML, Draper BW, Wahl GM. PMID: 7623808; PMCID: PMC230652.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5436-40.
Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, Bertino JR, Wahl GM. PMID: 7777526; PMCID: PMC41709.
View in:
PubMed Mentions:
88 Fields:
Translation:
AnimalsCells
-
Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Cancer Metastasis Rev. 1995 Mar; 14(1):59-73.
Almasan A, Linke SP, Paulson TG, Huang LC, Wahl GM. PMID: 7606822.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 1994 Nov 01; 8(21):2540-51.
Di Leonardo A, Linke SP, Clarkin K, Wahl GM. PMID: 7958916.
View in:
PubMed Mentions:
328 Fields:
Translation:
HumansCells
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Pharmacokinetics of hydroxyurea in nude mice. Anticancer Drugs. 1994 Oct; 5(5):573-8.
Van den Berg CL, McGill JR, Kuhn JG, Walsh JT, De La Cruz PS, Davidson KK, Wahl GM, Von Hoff DD. PMID: 7858290.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6674-8.
Eckhardt SG, Dai A, Davidson KK, Forseth BJ, Wahl GM, Von Hoff DD. PMID: 8022834; PMCID: PMC44265.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Chromosomal localization of the human retinoid X receptors. Genomics. 1994 Apr; 20(3):397-403.
Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM. PMID: 8034312.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci. Mol Cell Biol. 1993 May; 13(5):2971-81.
Carroll SM, DeRose ML, Kolman JL, Nonet GH, Kelly RE, Wahl GM. PMID: 8474455; PMCID: PMC359690.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Introduction of YACs containing a putative mammalian replication origin into mammalian cells can generate structures that replicate autonomously. Somat Cell Mol Genet. 1993 Mar; 19(2):171-92.
Nonet GH, Wahl GM. PMID: 8511674.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Molecular dissection of an extrachromosomal amplicon reveals a circular structure consisting of an imperfect inverted duplication. Genomics. 1993 Mar; 15(3):543-58.
Nonet GH, Carroll SM, DeRose ML, Wahl GM. PMID: 8468049.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Cell cycle regulation of gene amplification. Cold Spring Harb Symp Quant Biol. 1993; 58:655-67.
Di Leonardo A, Linke SP, Yin Y, Wahl GM. PMID: 7956082.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Effect of genomic position on amplification of the DFR1 gene in Saccharomyces cerevisiae. Adv Exp Med Biol. 1993; 338:545-50.
Barclay BJ, Ondrusek NK, Wildenhain YD, Huang T, Carlone RL, Clement JM, Wahl GM. PMID: 8304177.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell. 1992 Sep 18; 70(6):937-48.
Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM. PMID: 1525830.
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PubMed Mentions:
270 Fields:
Translation:
HumansCells
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Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8165-9.
Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, Van Devanter DR, Wahl GM. PMID: 1518843; PMCID: PMC49877.
View in:
PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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c-myc oncogene copy number in squamous carcinoma of the head and neck. Am J Otolaryngol. 1992 May-Jun; 13(3):168-71.
Haughey BH, von Hoff DD, Windle BE, Wahl GM, Mock PM. PMID: 1626617.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
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Molecular dissection of mammalian gene amplification: new mechanistic insights revealed by analyses of very early events. Mutat Res. 1992 May; 276(3):199-224.
Windle BE, Wahl GM. PMID: 1374515.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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A branching process model of gene amplification following chromosome breakage. Mutat Res. 1992 May; 276(3):225-39.
Kimmel M, Axelrod DE, Wahl GM. PMID: 1374516.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells. Cancer Res. 1991 Dec 01; 51(23 Pt 1):6273-9.
Von Hoff DD, Waddelow T, Forseth B, Davidson K, Scott J, Wahl G. PMID: 1682044.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Replication timing control can be maintained in extrachromosomally amplified genes. Mol Cell Biol. 1991 Sep; 11(9):4779-85.
Carroll SM, Trotter J, Wahl GM. PMID: 1678857; PMCID: PMC361380.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science. 1991 Mar 15; 251(4999):1351-5.
O'Gorman S, Fox DT, Wahl GM. PMID: 1900642.
View in:
PubMed Mentions:
206 Fields:
Translation:
AnimalsCells
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Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs. 1991 Feb; 2(1):11-25.
Benner SE, Wahl GM, Von Hoff DD. PMID: 1720337.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev. 1991 Feb; 5(2):160-74.
Windle B, Draper BW, Yin YX, O'Gorman S, Wahl GM. PMID: 1995414.
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PubMed Mentions:
70 Fields:
Translation:
AnimalsCells
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Chromosomal destabilization during gene amplification. Mol Cell Biol. 1990 Jun; 10(6):3056-66.
Ruiz JC, Wahl GM. PMID: 2188107; PMCID: PMC360670.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplification scheme. Gene. 1990 Apr 30; 89(1):117-22.
Barringer KJ, Orgel L, Wahl G, Gingeras TR. PMID: 2197176.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Recent progress in understanding mechanisms of mammalian DNA amplification. Cell. 1989 Jun 16; 57(6):901-8.
Stark GR, Debatisse M, Giulotto E, Wahl GM. PMID: 2661014.
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PubMed Mentions:
124 Fields:
Translation:
HumansAnimalsCells
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The importance of circular DNA in mammalian gene amplification. Cancer Res. 1989 Mar 15; 49(6):1333-40.
Wahl GM. PMID: 2647287.
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PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. Mol Cell Biol. 1989 Jan; 9(1):109-15.
Ruiz JC, Choi KH, von Hoff DD, Roninson IB, Wahl GM. PMID: 2648129; PMCID: PMC362151.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Formation of an inverted duplication can be an initial step in gene amplification. Mol Cell Biol. 1988 Oct; 8(10):4302-13.
Ruiz JC, Wahl GM. PMID: 3185551; PMCID: PMC365503.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4804-8.
Von Hoff DD, Needham-VanDevanter DR, Yucel J, Windle BE, Wahl GM. PMID: 3164477; PMCID: PMC280524.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Double minute chromosomes can be produced from precursors derived from a chromosomal deletion. Mol Cell Biol. 1988 Apr; 8(4):1525-33.
Carroll SM, DeRose ML, Gaudray P, Moore CM, Needham-Vandevanter DR, Von Hoff DD, Wahl GM. PMID: 2898098; PMCID: PMC363312.
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PubMed Mentions:
108 Fields:
Translation:
AnimalsCells
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Mapping and sequencing of the dihydrofolate reductase gene (DFR1) of Saccharomyces cerevisiae. Gene. 1988 Mar 31; 63(2):175-85.
Barclay BJ, Huang T, Nagel MG, Misener VL, Game JC, Wahl GM. PMID: 2838386.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol Cell Biol. 1987 May; 7(5):1740-50.
Carroll SM, Gaudray P, De Rose ML, Emery JF, Meinkoth JL, Nakkim E, Subler M, Von Hoff DD, Wahl GM. PMID: 2885742; PMCID: PMC365275.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. Mol Cell Biol. 1987 Apr; 7(4):1415-24.
Meinkoth J, Killary AM, Fournier RE, Wahl GM. PMID: 3600632; PMCID: PMC365229.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Escherichia coli aspartate transcarbamylase: a novel marker for studies of gene amplification and expression in mammalian cells. Mol Cell Biol. 1986 Sep; 6(9):3050-8.
Ruiz JC, Wahl GM. PMID: 3537729; PMCID: PMC367039.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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New RNA species is produced by alternate polyadenylation following rearrangement associated with CAD gene amplification. Somat Cell Mol Genet. 1986 Jul; 12(4):339-50.
Meinkoth JL, Legouy E, Brison O, Wahl GM. PMID: 2426798.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase. J Biol Chem. 1986 May 15; 261(14):6285-92.
Gaudray P, Trotter J, Wahl GM. PMID: 3700393.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Effect of chromosomal position on amplification of transfected genes in animal cells. Nature. 1984 Feb 9-15; 307(5951):516-20.
Wahl GM, Robert de Saint Vincent B, DeRose ML. PMID: 6694743.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Gene amplification. Annu Rev Biochem. 1984; 53:447-91.
Stark GR, Wahl GM. PMID: 6383198.
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PubMed Mentions:
197 Fields:
Translation:
AnimalsCells
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Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells. Mol Cell Biol. 1983 Nov; 3(11):2066-75.
Wahl GM, Vitto L, Rubnitz J. PMID: 6318080; PMCID: PMC370073.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Derivatization of unprotected polynucleotides. Nucleic Acids Res. 1983 Sep 24; 11(18):6513-29.
Chu BC, Wahl GM, Orgel LE. PMID: 6622259; PMCID: PMC326391.
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PubMed Mentions:
39 Fields:
Translation:
Cells
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Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):2002-6.
de Saint Vincent BR, Wahl GM. PMID: 6132383; PMCID: PMC393740.
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PubMed Mentions:
62 Fields:
Translation:
Animals
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Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol. 1982 Nov; 2(11):1372-87.
Folger KR, Wong EA, Wahl G, Capecchi MR. PMID: 6298598; PMCID: PMC369942.
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PubMed Mentions:
187 Fields:
Translation:
AnimalsCells
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Patents and literature. Appl Biochem Biotechnol. 1982 May; 7(3):217-30.
Kit M, Narasimhan MJ, Anderson JA, Zimmermann U, Pilwat G, Furuya T, Tani Y, Kolehmainen SE, Tarkkanen V, Barrett SP, Gestrelius SM, Belloc A, Florent J, Lunel J, Palla J, Mancy D, Bailey JE, Cho YK, Mouri T, Kayama H, Foley SE, Oriel PJ, Epstein CC, Kimura K, Spraker PW, Ljungdahl LG, Wieget JK, Levine DW, Thilly WG, Wang DI, Wong JS, Eisinger MG, Young FE, Wilson GA, Mottice SL, Green H, Kehinde O, Buhler M, Olofsson M, Osseux PF, Degen L, Branduzzi P, Olivieri R, Cimini N, Kang KS, Veeder GT, Latymer Z, Andersen G, Drobot W, Monsheimer R, Pfleiderer E, Hidaka H, Kohno T, Eida T, Weisrock WP, Stevens VC, Takezawa K, Hiratani H, Wandrey C, Wichmann R, Leuchtenberger W, Kula M, Buckmann A, Troller J, Koshugi J, Frommer W, Muller L, Schmidt D, Puls W, Krause H, Heber U, Cohen SN, Wahl GM, Stark GR, Collins J, Hohn B, Sugano H, Matsui Y. PMID: 24234232.
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PubMed Mentions: Fields:
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Properties of dispersed, highly repeated DNA within and near the hamster CAD gene. Mol Cell Biol. 1982 Mar; 2(3):302-7.
Padgett RA, Wahl GM, Stark GR. PMID: 6180303; PMCID: PMC369789.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Mol Cell Biol. 1982 Mar; 2(3):308-19.
Wahl GM, Vitto L, Padgett RA, Stark GR. PMID: 6180304; PMCID: PMC369790.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. Mol Cell Biol. 1982 Mar; 2(3):293-301.
Padgett RA, Wahl GM, Stark GR. PMID: 6125880; PMCID: PMC369788.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker. Cell. 1981 Dec; 27(2 Pt 1):267-77.
de Saint Vincent BR, Delbrück S, Eckhart W, Meinkoth J, Vitto L, Wahl G. PMID: 6277500.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells. J Biol Chem. 1979 Sep 10; 254(17):8679-89.
Wahl GM, Padgett RA, Stark GR. PMID: 381311.
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PubMed Mentions:
150 Fields:
Translation:
AnimalsCells
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N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. J Biol Chem. 1979 Feb 10; 254(3):974-80.
Padgett RA, Wahl GM, Coleman PF, Stark GR. PMID: 762107.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods Enzymol. 1979; 68:220-42.
Alwine JC, Kemp DJ, Parker BA, Reiser J, Renart J, Stark GR, Wahl GM. PMID: 94421.
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PubMed Mentions:
233 Fields:
Translation:
Cells
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Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell. 1975 Nov; 6(3):269-77.
Capecchi MR, Hughes SH, Wahl GM. PMID: 802681.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol. 1975 Apr; 85(2 Pt 1):307-20.
Wahl GM, Hughes SH, Capecchi MR. PMID: 47331.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. J Biol Chem. 1975 Jan 10; 250(1):120-6.
Hughes SH, Wahl GM, Capecchi MR. PMID: 237883.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells