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Geoffrey Wahl

Title(s)Adjunct Professor, Molecular Biology
SchoolAcademic Aff
Phone858-453-4100
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    Collapse Research 
    Collapse Research Activities and Funding
    Combining single cell approaches and a developmental perspective to discover stem cell control circuits and the cellular and molecular bases of cancer heterogeneity
    NIH/NCI R35CA197687Aug 1, 2015 - Jul 31, 2022
    Role: Principal Investigator
    High throughput screen for inhibitors of the mdm2/mdmx interaction
    NIH/NIMH R03MH089489Feb 1, 2010 - Nov 30, 2011
    Role: Principal Investigator
    Mouse Models to Elucidate p53 Regulatory Mechanisms
    NIH/NCI R01CA100845Apr 15, 2003 - Mar 31, 2009
    Role: Principal Investigator
    DECONVOLUTION MICROSCOPE FOR LIVE CELL IMAGING
    NIH/NCRR S10RR013692Feb 16, 1999 - Feb 15, 2000
    Role: Principal Investigator
    DNA REPLICATION, CELL CYCLE CONTROL AND GENOME FLUIDITY
    NIH/NIGMS R01GM051104Aug 1, 1993 - Jul 31, 1998
    Role: Principal Investigator
    Mechanisms of Genetic Instability and Tumor Suppression
    NIH/NCI R01CA061449Jul 1, 1993 - Jul 31, 2011
    Role: Principal Investigator
    MOLECULAR GENETIC ANALYSIS OF MAMMALIAN DNA REPLICATION
    NIH/NCI R01CA048405Aug 1, 1988 - Mar 31, 2005
    Role: Principal Investigator
    DETECTION AND CURING OF AMPLIFIED GENES IN CANCER
    NIH/NCI U01CA048405Aug 1, 1988 - Jul 31, 1995
    Role: Principal Investigator
    FASEB RESEARCH CONF--CELLULAR AND MOLECULAR GENETICS
    NIH/NCI R13CA049116Jul 1, 1988 - Jun 30, 1989
    Role: Principal Investigator
    Salk Institute Cancer Training Grant
    NIH/NCI T32CA009370Sep 1, 1980 - Jun 30, 2022
    Role: Co-Principal Investigator
    DRUG RESISTANCE AND GENE AMPLIFICATION IN EUKARYOTES
    NIH/NIGMS R01GM027754Apr 1, 1980 - Jun 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chung CY, Ma Z, Dravis C, Preissl S, Poirion O, Luna G, Hou X, Giraddi RR, Ren B, Wahl GM. Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships. Cell Rep. 2019 Oct 08; 29(2):495-510.e6. PMID: 31597106.
      View in: PubMed
    2. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 05; 569(7754):131-135. PMID: 30996350.
      View in: PubMed
    3. Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell. 2018 09 10; 34(3):466-482.e6. PMID: 30174241.
      View in: PubMed
    4. Giraddi RR, Chung CY, Heinz RE, Balcioglu O, Novotny M, Trejo CL, Dravis C, Hagos BM, Mehrabad EM, Rodewald LW, Hwang JY, Fan C, Lasken R, Varley KE, Perou CM, Wahl GM, Spike BT. Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development. Cell Rep. 2018 08 07; 24(6):1653-1666.e7. PMID: 30089273.
      View in: PubMed
    5. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051. PMID: 29211796.
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    6. Trejo CL, Luna G, Dravis C, Spike BT, Wahl GM. Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. NPJ Breast Cancer. 2017; 3:16. PMID: 28649656.
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    7. Wahl GM, Spike BT. Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer. 2017; 3:14. PMID: 28649654.
      View in: PubMed
    8. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. PMID: 28178237.
      View in: PubMed
    9. Wang Y, Barry O, Wahl G, Chen B, Lin Y. [Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Aug 18; 48(4):697-701. PMID: 29263516.
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    10. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte JC. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743. PMID: 26899176.
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    11. Wang Y, Barry O, Wahl G, Chen B, Lin Y. [Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Feb 18; 48(1):697-701. PMID: 27538155.
      View in: PubMed
    12. Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM. Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep. 2015 Sep 29; 12(12):2035-48. PMID: 26365194.
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    13. Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 09; 55(9):1387-96. PMID: 26310697.
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    14. Rozhok AI, Wahl GM, DeGregori J. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila). 2015 Sep; 8(9):762-4. PMID: 26122457.
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    15. Pfefferle AD, Spike BT, Wahl GM, Perou CM. Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat. 2015 Jan; 149(2):425-37. PMID: 25575446.
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    16. Li YC, Rodewald LW, Hoppmann C, Wong ET, Lebreton S, Safar P, Patek M, Wang L, Wertman KF, Wahl GM. A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11; 9(5):1946-1958. PMID: 25464845.
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    17. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. PMID: 25259922.
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    18. Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl GM, Gray PC. CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports. 2014 Apr 08; 2(4):427-39. PMID: 24749068.
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    19. Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013 Nov 12; 14(11):R125. PMID: 24220145.
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    20. He G, Zhang YW, Lee JH, Zeng SX, Wang YV, Luo Z, Dong XC, Viollet B, Wahl GM, Lu H. AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol. 2014 Jan; 34(2):148-57. PMID: 24190973.
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    21. Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl GM, Rathmell WK. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem. 2013 Sep 06; 288(36):26301-10. PMID: 23893409.
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    22. Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM, Eaves CJ. Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia. 2013 Jun; 18(2):209-19. PMID: 23624881.
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    23. Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl GM. Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6991-6. PMID: 23559372.
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    24. Green JL, Bauer M, Yum KW, Li YC, Cox ML, Willert K, Wahl GM. Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. PLoS One. 2013; 8(3):e58395. PMID: 23516471.
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    25. Wade M, Li YC, Wahl GM. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 2013 Feb; 13(2):83-96. PMID: 23303139.
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    26. Li YC, Wahl GM. What a difference a phosphate makes: life or death decided by a single amino acid in MDM2. Cancer Cell. 2012 May 15; 21(5):595-6. PMID: 22624708.
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    27. Lee JH, Jin Y, He G, Zeng SX, Wang YV, Wahl GM, Lu H. Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3? inactivation of MDMX protein. J Biol Chem. 2012 Jun 15; 287(25):20898-903. PMID: 22556425.
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    28. Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell. 2012 Feb 03; 10(2):183-97. PMID: 22305568.
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    29. Wade M, Li YC, Matani AS, Braun SM, Milanesi F, Rodewald LW, Wahl GM. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene. 2012 Nov 08; 31(45):4789-97. PMID: 22266850.
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    30. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. PMID: 21724834.
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    31. Spike BT, Wahl GM. p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer. 2011 Apr; 2(4):404-19. PMID: 21779509.
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    32. Mizuno H, Spike BT, Wahl GM, Levine AJ. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22745-50. PMID: 21149740.
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    33. Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16; 18(5):411-22. PMID: 21075307.
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    34. Wade M, Wang YV, Wahl GM. The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol. 2010 May; 20(5):299-309. PMID: 20172729.
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    35. Wang YV, Wade M, Wahl GM. Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo. Cell Cycle. 2009 Nov 01; 8(21):3443-4. PMID: 19838055.
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    36. Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl GM, Nister M, Weinberg WC. The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol. 2009 Oct; 219(2):263-74. PMID: 19718706.
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    37. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Izpisúa Belmonte JC. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009 Aug 27; 460(7259):1140-4. PMID: 19668186.
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    38. Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell. 2009 Jul 07; 16(1):33-43. PMID: 19573810.
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    39. Wade M, Wahl GM. Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res. 2009 Jan; 7(1):1-11. PMID: 19147532.
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    40. Wade M, Rodewald LW, Espinosa JM, Wahl GM. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle. 2008 Jul 01; 7(13):1973-82. PMID: 18604177.
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    41. Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12365-70. PMID: 17640893.
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    42. Toledo F, Wahl GM. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Int J Biochem Cell Biol. 2007; 39(7-8):1476-82. PMID: 17499002.
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    43. Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM. Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 2007 Feb; 27(4):1425-32. PMID: 17158931.
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    44. Toledo F, Wahl GM. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer. 2006 Dec; 6(12):909-23. PMID: 17128209.
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    45. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006 Oct 01; 66(19):9339-44. PMID: 16990346.
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    46. Wade M, Wong ET, Tang M, Stommel JM, Wahl GM. Hdmx modulates the outcome of p53 activation in human tumor cells. J Biol Chem. 2006 Nov 03; 281(44):33036-44. PMID: 16905769.
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    47. Toledo F, Liu CW, Lee CJ, Wahl GM. RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic Acids Res. 2006 Jul 26; 34(13):e92. PMID: 16870721.
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    48. Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 2006 Jun; 13(6):927-34. PMID: 16543935.
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    49. Wahl GM. Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo. Cell Death Differ. 2006 Jun; 13(6):973-83. PMID: 16575406.
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    50. Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell. 2006 Apr; 9(4):273-85. PMID: 16616333.
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    51. Tang M, Wahl GM, Nistér M. Explaining the biological activity of transactivation-deficient p53 variants. Nat Genet. 2006 Apr; 38(4):395-6; author reply 396-7. PMID: 16570054.
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    52. Wade M, Wahl GM. c-Myc, genome instability, and tumorigenesis: the devil is in the details. Curr Top Microbiol Immunol. 2006; 302:169-203. PMID: 16620029.
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    53. Wong ET, Kolman JL, Li YC, Mesner LD, Hillen W, Berens C, Wahl GM. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res. 2005 Oct 04; 33(17):e147. PMID: 16204450.
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    54. Buzina A, Aladjem MI, Kolman JL, Wahl GM, Ellis J. Initiation of DNA replication at the human beta-globin 3' enhancer. Nucleic Acids Res. 2005; 33(14):4412-24. PMID: 16085752.
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    55. Krummel KA, Lee CJ, Toledo F, Wahl GM. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10188-93. PMID: 16006521.
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    56. Nistér M, Tang M, Zhang XQ, Yin C, Beeche M, Hu X, Enblad G, van Dyke T, Wahl GM. p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene. 2005 May 19; 24(22):3563-73. PMID: 15750633.
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    57. Stommel JM, Wahl GM. A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation. Cell Cycle. 2005 Mar; 4(3):411-7. PMID: 15684615.
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    58. Thompson T, Tovar C, Yang H, Carvajal D, Vu BT, Xu Q, Wahl GM, Heimbrook DC, Vassilev LT. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem. 2004 Dec 17; 279(51):53015-22. PMID: 15471885.
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    59. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR, Hoffman RM. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res. 2004 Jun 15; 64(12):4251-6. PMID: 15205338.
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    60. Stommel JM, Wahl GM. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J. 2004 Apr 07; 23(7):1547-56. PMID: 15029243.
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    61. Sears J, Kolman J, Wahl GM, Aiyar A. Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1. J Virol. 2003 Nov; 77(21):11767-80. PMID: 14557661.
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    62. Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell. 2002 Jun; 1(5):493-503. PMID: 12124178.
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    63. Li Q, Lee JY, Castillo R, Hixon MS, Pujol C, Doppalapudi VR, Shepard HM, Wahl GM, Lobl TJ, Chan MF. NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against beta-lactamase-producing strains. Antimicrob Agents Chemother. 2002 May; 46(5):1262-8. PMID: 11959554.
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    64. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell. 2002 May; 9(5):1031-44. PMID: 12049739.
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    65. Neuteboom ST, Karjian PL, Boyer CR, Beryt M, Pegram M, Wahl GM, Shepard HM. Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. Mol Cancer Ther. 2002 Apr; 1(6):377-84. PMID: 12477050.
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    66. Aladjem MI, Rodewald LW, Lin CM, Bowman S, Cimbora DM, Brody LL, Epner EM, Groudine M, Wahl GM. Replication initiation patterns in the beta-globin loci of totipotent and differentiated murine cells: evidence for multiple initiation regions. Mol Cell Biol. 2002 Jan; 22(2):442-52. PMID: 11756541.
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    67. Boyer CR, Karjian PL, Wahl GM, Pegram M, Neuteboom ST. Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011. Anticancer Drugs. 2002 Jan; 13(1):29-36. PMID: 11914638.
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    68. Wahl GM, Carr AM. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol. 2001 Dec; 3(12):E277-86. PMID: 11781586.
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    69. Kanda T, Otter M, Wahl GM. Coupling of mitotic chromosome tethering and replication competence in epstein-barr virus-based plasmids. Mol Cell Biol. 2001 May; 21(10):3576-88. PMID: 11313483.
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    70. Kanda T, Otter M, Wahl GM. Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering. J Cell Sci. 2001 Jan; 114(Pt 1):49-58. PMID: 11112689.
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    71. Jimenez GS, Nister M, Stommel JM, Beeche M, Barcarse EA, Zhang XQ, O'Gorman S, Wahl GM. A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nat Genet. 2000 Sep; 26(1):37-43. PMID: 10973245.
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    72. Khan SH, Moritsugu J, Wahl GM. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3266-71. PMID: 10716710.
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    73. Kanda T, Wahl GM. The dynamics of acentric chromosomes in cancer cells revealed by GFP-based chromosome labeling strategies. J Cell Biochem Suppl. 2000; Suppl 35:107-14. PMID: 11389539.
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    74. Wahl G, Vafa O. Genetic instability, oncogenes, and the p53 pathway. Cold Spring Harb Symp Quant Biol. 2000; 65:511-20. PMID: 12760068.
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    75. Jimenez GS, Khan SH, Stommel JM, Wahl GM. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses. Oncogene. 1999 Dec 13; 18(53):7656-65. PMID: 10618705.
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    76. Fox RI, Herrmann ML, Frangou CG, Wahl GM, Morris RE, Strand V, Kirschbaum BJ. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec; 93(3):198-208. PMID: 10600330.
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    77. Fox RI, Herrmann ML, Frangou CG, Wahl GM, Morris RE, Kirschbaum BJ. How does leflunomide modulate the immune response in rheumatoid arthritis? BioDrugs. 1999 Oct; 12(4):301-15. PMID: 18031184.
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    82. Jiang W, Jimenez G, Wells NJ, Hope TJ, Wahl GM, Hunter T, Fukunaga R. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec; 2(6):877-85. PMID: 9885575.
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    83. Aladjem MI, Rodewald LW, Kolman JL, Wahl GM. Genetic dissection of a mammalian replicator in the human beta-globin locus. Science. 1998 Aug 14; 281(5379):1005-9. PMID: 9703500.
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    87. Khan SH, Wahl GM. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res. 1998 Feb 01; 58(3):396-401. PMID: 9458079.
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    91. Brown M, Parker D, Seeland E, Boyle D, Wahl G. Five years of work-related injuries and fatalities in Minnesota. Agriculture: a high-risk industry. Minn Med. 1997 Aug; 80(8):29-32. PMID: 9265823.
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    92. Linke SP, Harris MP, Neugebauer SE, Clarkin KC, Shepard HM, Maneval DC, Wahl GM. p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression. Oncogene. 1997 Jul 17; 15(3):337-45. PMID: 9233768.
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    93. Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res. 1997 Mar 15; 57(6):1013-9. PMID: 9067261.
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    94. Linke SP, Clarkin KC, Wahl GM. p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation. Cancer Res. 1997 Mar 15; 57(6):1171-9. PMID: 9067289.
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    95. Aladjem MI, Brody LL, O'Gorman S, Wahl GM. Positive selection of FLP-mediated unequal sister chromatid exchange products in mammalian cells. Mol Cell Biol. 1997 Feb; 17(2):857-61. PMID: 9001240.
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    96. Wahl GM, Linke SP, Paulson TG, Huang LC. Maintaining genetic stability through TP53 mediated checkpoint control. Cancer Surv. 1997; 29:183-219. PMID: 9338102.
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    97. Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl GM, Bradley A. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14106-11. PMID: 8943068.
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    98. Paulson TG, Wright FA, Parker BA, Russack V, Wahl GM. Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer. Cancer Res. 1996 Sep 01; 56(17):4021-6. PMID: 8752173.
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    99. Huang LC, Clarkin KC, Wahl GM. p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res. 1996 Jul 01; 56(13):2940-4. PMID: 8674045.
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    100. Huang LC, Clarkin KC, Wahl GM. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4827-32. PMID: 8643488.
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    101. Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 1996 Apr 15; 10(8):934-47. PMID: 8608941.
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    102. Shimizu N, Kanda T, Wahl GM. Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. Nat Genet. 1996 Jan; 12(1):65-71. PMID: 8528254.
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    103. Aladjem MI, Groudine M, Brody LL, Dieken ES, Fournier RE, Wahl GM, Epner EM. Participation of the human beta-globin locus control region in initiation of DNA replication. Science. 1995 Nov 03; 270(5237):815-9. PMID: 7481774.
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    104. Li W, Fan J, Hochhauser D, Banerjee D, Zielinski Z, Almasan A, Yin Y, Kelly R, Wahl GM, Bertino JR. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10436-40. PMID: 7479800.
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    105. Kelly RE, DeRose ML, Draper BW, Wahl GM. Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene. Mol Cell Biol. 1995 Aug; 15(8):4136-48. PMID: 7623808.
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    106. Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, Bertino JR, Wahl GM. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5436-40. PMID: 7777526.
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    107. Almasan A, Linke SP, Paulson TG, Huang LC, Wahl GM. Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Cancer Metastasis Rev. 1995 Mar; 14(1):59-73. PMID: 7606822.
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    108. Di Leonardo A, Linke SP, Clarkin K, Wahl GM. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 1994 Nov 01; 8(21):2540-51. PMID: 7958916.
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    109. Van den Berg CL, McGill JR, Kuhn JG, Walsh JT, De La Cruz PS, Davidson KK, Wahl GM, Von Hoff DD. Pharmacokinetics of hydroxyurea in nude mice. Anticancer Drugs. 1994 Oct; 5(5):573-8. PMID: 7858290.
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    110. Eckhardt SG, Dai A, Davidson KK, Forseth BJ, Wahl GM, Von Hoff DD. Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6674-8. PMID: 8022834.
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    111. Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM. Chromosomal localization of the human retinoid X receptors. Genomics. 1994 Apr; 20(3):397-403. PMID: 8034312.
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    112. Carroll SM, DeRose ML, Kolman JL, Nonet GH, Kelly RE, Wahl GM. Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci. Mol Cell Biol. 1993 May; 13(5):2971-81. PMID: 8474455.
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    113. Nonet GH, Carroll SM, DeRose ML, Wahl GM. Molecular dissection of an extrachromosomal amplicon reveals a circular structure consisting of an imperfect inverted duplication. Genomics. 1993 Mar; 15(3):543-58. PMID: 8468049.
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    114. Nonet GH, Wahl GM. Introduction of YACs containing a putative mammalian replication origin into mammalian cells can generate structures that replicate autonomously. Somat Cell Mol Genet. 1993 Mar; 19(2):171-92. PMID: 8511674.
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    115. Di Leonardo A, Linke SP, Yin Y, Wahl GM. Cell cycle regulation of gene amplification. Cold Spring Harb Symp Quant Biol. 1993; 58:655-67. PMID: 7956082.
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    116. Barclay BJ, Ondrusek NK, Wildenhain YD, Huang T, Carlone RL, Clement JM, Wahl GM. Effect of genomic position on amplification of the DFR1 gene in Saccharomyces cerevisiae. Adv Exp Med Biol. 1993; 338:545-50. PMID: 8304177.
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    117. Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell. 1992 Sep 18; 70(6):937-48. PMID: 1525830.
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    118. Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, Van Devanter DR, Wahl GM. Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8165-9. PMID: 1518843.
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    119. Windle BE, Wahl GM. Molecular dissection of mammalian gene amplification: new mechanistic insights revealed by analyses of very early events. Mutat Res. 1992 May; 276(3):199-224. PMID: 1374515.
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    120. Kimmel M, Axelrod DE, Wahl GM. A branching process model of gene amplification following chromosome breakage. Mutat Res. 1992 May; 276(3):225-39. PMID: 1374516.
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    121. Haughey BH, von Hoff DD, Windle BE, Wahl GM, Mock PM. c-myc oncogene copy number in squamous carcinoma of the head and neck. Am J Otolaryngol. 1992 May-Jun; 13(3):168-71. PMID: 1626617.
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    122. Von Hoff DD, Waddelow T, Forseth B, Davidson K, Scott J, Wahl G. Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells. Cancer Res. 1991 Dec 01; 51(23 Pt 1):6273-9. PMID: 1682044.
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    123. Carroll SM, Trotter J, Wahl GM. Replication timing control can be maintained in extrachromosomally amplified genes. Mol Cell Biol. 1991 Sep; 11(9):4779-85. PMID: 1678857.
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    124. O'Gorman S, Fox DT, Wahl GM. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science. 1991 Mar 15; 251(4999):1351-5. PMID: 1900642.
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    125. Windle B, Draper BW, Yin YX, O'Gorman S, Wahl GM. A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev. 1991 Feb; 5(2):160-74. PMID: 1995414.
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    126. Benner SE, Wahl GM, Von Hoff DD. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs. 1991 Feb; 2(1):11-25. PMID: 1720337.
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    127. Ruiz JC, Wahl GM. Chromosomal destabilization during gene amplification. Mol Cell Biol. 1990 Jun; 10(6):3056-66. PMID: 2188107.
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    128. Barringer KJ, Orgel L, Wahl G, Gingeras TR. Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplification scheme. Gene. 1990 Apr 30; 89(1):117-22. PMID: 2197176.
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    129. Stark GR, Debatisse M, Giulotto E, Wahl GM. Recent progress in understanding mechanisms of mammalian DNA amplification. Cell. 1989 Jun 16; 57(6):901-8. PMID: 2661014.
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    130. Wahl GM. The importance of circular DNA in mammalian gene amplification. Cancer Res. 1989 Mar 15; 49(6):1333-40. PMID: 2647287.
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    131. Ruiz JC, Choi KH, von Hoff DD, Roninson IB, Wahl GM. Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. Mol Cell Biol. 1989 Jan; 9(1):109-15. PMID: 2648129.
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    132. Ruiz JC, Wahl GM. Formation of an inverted duplication can be an initial step in gene amplification. Mol Cell Biol. 1988 Oct; 8(10):4302-13. PMID: 3185551.
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    133. Von Hoff DD, Needham-VanDevanter DR, Yucel J, Windle BE, Wahl GM. Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4804-8. PMID: 3164477.
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    134. Carroll SM, DeRose ML, Gaudray P, Moore CM, Needham-Vandevanter DR, Von Hoff DD, Wahl GM. Double minute chromosomes can be produced from precursors derived from a chromosomal deletion. Mol Cell Biol. 1988 Apr; 8(4):1525-33. PMID: 2898098.
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    135. Carroll SM, Gaudray P, De Rose ML, Emery JF, Meinkoth JL, Nakkim E, Subler M, Von Hoff DD, Wahl GM. Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol Cell Biol. 1987 May; 7(5):1740-50. PMID: 2885742.
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    136. Meinkoth J, Killary AM, Fournier RE, Wahl GM. Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. Mol Cell Biol. 1987 Apr; 7(4):1415-24. PMID: 3600632.
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    137. Ruiz JC, Wahl GM. Escherichia coli aspartate transcarbamylase: a novel marker for studies of gene amplification and expression in mammalian cells. Mol Cell Biol. 1986 Sep; 6(9):3050-8. PMID: 3537729.
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    138. Meinkoth JL, Legouy E, Brison O, Wahl GM. New RNA species is produced by alternate polyadenylation following rearrangement associated with CAD gene amplification. Somat Cell Mol Genet. 1986 Jul; 12(4):339-50. PMID: 2426798.
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    139. Gaudray P, Trotter J, Wahl GM. Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase. J Biol Chem. 1986 May 15; 261(14):6285-92. PMID: 3700393.
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    140. Wahl GM, Robert de Saint Vincent B, DeRose ML. Effect of chromosomal position on amplification of transfected genes in animal cells. Nature. 1984 Feb 9-15; 307(5951):516-20. PMID: 6694743.
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    141. Stark GR, Wahl GM. Gene amplification. Annu Rev Biochem. 1984; 53:447-91. PMID: 6383198.
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    142. Wahl GM, Vitto L, Rubnitz J. Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells. Mol Cell Biol. 1983 Nov; 3(11):2066-75. PMID: 6318080.
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    143. Chu BC, Wahl GM, Orgel LE. Derivatization of unprotected polynucleotides. Nucleic Acids Res. 1983 Sep 24; 11(18):6513-29. PMID: 6622259.
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    144. de Saint Vincent BR, Wahl GM. Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):2002-6. PMID: 6132383.
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    145. Folger KR, Wong EA, Wahl G, Capecchi MR. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol. 1982 Nov; 2(11):1372-87. PMID: 6298598.
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    146. Padgett RA, Wahl GM, Stark GR. Properties of dispersed, highly repeated DNA within and near the hamster CAD gene. Mol Cell Biol. 1982 Mar; 2(3):302-7. PMID: 6180303.
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    147. Wahl GM, Vitto L, Padgett RA, Stark GR. Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Mol Cell Biol. 1982 Mar; 2(3):308-19. PMID: 6180304.
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    148. Padgett RA, Wahl GM, Stark GR. Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. Mol Cell Biol. 1982 Mar; 2(3):293-301. PMID: 6125880.
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    149. de Saint Vincent BR, Delbrück S, Eckhart W, Meinkoth J, Vitto L, Wahl G. The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker. Cell. 1981 Dec; 27(2 Pt 1):267-77. PMID: 6277500.
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    150. Wahl GM, Padgett RA, Stark GR. Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells. J Biol Chem. 1979 Sep 10; 254(17):8679-89. PMID: 381311.
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    151. Padgett RA, Wahl GM, Coleman PF, Stark GR. N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. J Biol Chem. 1979 Feb 10; 254(3):974-80. PMID: 762107.
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    152. Alwine JC, Kemp DJ, Parker BA, Reiser J, Renart J, Stark GR, Wahl GM. Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods Enzymol. 1979; 68:220-42. PMID: 94421.
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    153. Capecchi MR, Hughes SH, Wahl GM. Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell. 1975 Nov; 6(3):269-77. PMID: 802681.
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    154. Wahl GM, Hughes SH, Capecchi MR. Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol. 1975 Apr; 85(2 Pt 1):307-20. PMID: 47331.
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