Loading...

Geoffrey Wahl

Title(s)Adjunct Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #0932
La Jolla CA 92093
Phone8/4-53--4100
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunity
    NIH/NCI R01CA240909Mar 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Combining single cell approaches and a developmental perspective to discover stem cell control circuits and the cellular and molecular bases of cancer heterogeneity
    NIH/NCI R35CA197687Aug 1, 2015 - Jul 31, 2022
    Role: Principal Investigator
    High throughput screen for inhibitors of the mdm2/mdmx interaction
    NIH/NIMH R03MH089489Feb 1, 2010 - Nov 30, 2011
    Role: Principal Investigator
    Mouse Models to Elucidate p53 Regulatory Mechanisms
    NIH/NCI R01CA100845Apr 15, 2003 - Mar 31, 2009
    Role: Principal Investigator
    DECONVOLUTION MICROSCOPE FOR LIVE CELL IMAGING
    NIH/NCRR S10RR013692Feb 16, 1999 - Feb 15, 2000
    Role: Principal Investigator
    DNA REPLICATION, CELL CYCLE CONTROL AND GENOME FLUIDITY
    NIH/NIGMS R01GM051104Aug 1, 1993 - Jul 31, 1998
    Role: Principal Investigator
    Mechanisms of Genetic Instability and Tumor Suppression
    NIH/NCI R01CA061449Jul 1, 1993 - Sep 27, 2006
    Role: Principal Investigator
    MOLECULAR GENETIC ANALYSIS OF MAMMALIAN DNA REPLICATION
    NIH/NCI R01CA048405Aug 1, 1988 - May 31, 1999
    Role: Principal Investigator
    DETECTION AND CURING OF AMPLIFIED GENES IN CANCER
    NIH/NCI U01CA048405Aug 1, 1988 - Jul 31, 1995
    Role: Principal Investigator
    FASEB RESEARCH CONF--CELLULAR AND MOLECULAR GENETICS
    NIH/NCI R13CA049116Jul 1, 1988 - Jun 30, 1989
    Role: Principal Investigator
    Salk Institute Cancer Training Grant
    NIH/NCI T32CA009370Sep 1, 1980 - Sep 28, 2011
    Role: Co-Principal Investigator
    DRUG RESISTANCE AND GENE AMPLIFICATION IN EUKARYOTES
    NIH/NIGMS R01GM027754Apr 1, 1980 - Mar 31, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. Gastroenterology. 2020 Jul 24. DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM. PMID: 32717220.
      View in: PubMed   Mentions:    Fields:    
    2. Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. Cell Rep. 2020 Jun 09; 31(10):107742. Christin JR, Wang C, Chung CY, Liu Y, Dravis C, Tang W, Oktay MH, Wahl GM, Guo W. PMID: 32521267.
      View in: PubMed   Mentions:    Fields:    
    3. Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12121-12130. Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. PMID: 32424096.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020 04 03; 368(6486):85-89. Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. PMID: 32241947.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    5. Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis. Front Physiol. 2020; 11:88. DelGiorno KE, Naeem RF, Fang L, Chung CY, Ramos C, Luhtala N, O'Connor C, Hunter T, Manor U, Wahl GM. PMID: 32116793.
      View in: PubMed   Mentions:
    6. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Sci Alliance. 2020 01; 3(1). Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW. PMID: 31959624.
      View in: PubMed   Mentions:    Fields:    
    7. DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. Cell Rep. 2019 12 10; 29(11):3448-3459.e6. Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC. PMID: 31825828.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships. Cell Rep. 2019 10 08; 29(2):495-510.e6. Chung CY, Ma Z, Dravis C, Preissl S, Poirion O, Luna G, Hou X, Giraddi RR, Ren B, Wahl GM. PMID: 31597106.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 05; 569(7754):131-135. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 30996350.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    10. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell. 2018 09 10; 34(3):466-482.e6. Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. PMID: 30174241.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development. Cell Rep. 2018 08 07; 24(6):1653-1666.e7. Giraddi RR, Chung CY, Heinz RE, Balcioglu O, Novotny M, Trejo CL, Dravis C, Hagos BM, Mehrabad EM, Rodewald LW, Hwang JY, Fan C, Lasken R, Varley KE, Perou CM, Wahl GM, Spike BT. PMID: 30089273.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    12. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM. PMID: 29211796.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. NPJ Breast Cancer. 2017; 3:16. Trejo CL, Luna G, Dravis C, Spike BT, Wahl GM. PMID: 28649656.
      View in: PubMed   Mentions:
    14. Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer. 2017; 3:14. Wahl GM, Spike BT. PMID: 28649654.
      View in: PubMed   Mentions:
    15. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    16. [Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Aug 18; 48(4):697-701. Wang Y, Barry O, Wahl G, Chen B, Lin Y. PMID: 29263516.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte JC. PMID: 26899176.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    18. [Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Feb 18; 48(1):697-701. Wang Y, Barry O, Wahl G, Chen B, Lin Y. PMID: 27538155.
      View in: PubMed   Mentions:    Fields:    
    19. Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep. 2015 Sep 29; 12(12):2035-48. Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM. PMID: 26365194.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    20. The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 09; 55(9):1387-96. Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. PMID: 26310697.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila). 2015 Sep; 8(9):762-4. Rozhok AI, Wahl GM, DeGregori J. PMID: 26122457.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat. 2015 Jan; 149(2):425-37. Pfefferle AD, Spike BT, Wahl GM, Perou CM. PMID: 25575446.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    23. A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11; 9(5):1946-1958. Li YC, Rodewald LW, Hoppmann C, Wong ET, Lebreton S, Safar P, Patek M, Wang L, Wertman KF, Wahl GM. PMID: 25464845.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    24. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. PMID: 25259922.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansAnimalsCells
    25. CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports. 2014 Apr 08; 2(4):427-39. Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl GM, Gray PC. PMID: 24749068.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    26. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013 Nov 12; 14(11):R125. Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. PMID: 24220145.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    27. AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol. 2014 Jan; 34(2):148-57. He G, Zhang YW, Lee JH, Zeng SX, Wang YV, Luo Z, Dong XC, Viollet B, Wahl GM, Lu H. PMID: 24190973.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    28. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem. 2013 Sep 06; 288(36):26301-10. Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl GM, Rathmell WK. PMID: 23893409.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    29. Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia. 2013 Jun; 18(2):209-19. Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM, Eaves CJ. PMID: 23624881.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    30. Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6991-6. Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl GM. PMID: 23559372.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    31. Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. PLoS One. 2013; 8(3):e58395. Green JL, Bauer M, Yum KW, Li YC, Cox ML, Willert K, Wahl GM. PMID: 23516471.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 2013 Feb; 13(2):83-96. Wade M, Li YC, Wahl GM. PMID: 23303139.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimals
    33. What a difference a phosphate makes: life or death decided by a single amino acid in MDM2. Cancer Cell. 2012 May 15; 21(5):595-6. Li YC, Wahl GM. PMID: 22624708.
      View in: PubMed   Mentions: 1     Fields:    
    34. Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3? inactivation of MDMX protein. J Biol Chem. 2012 Jun 15; 287(25):20898-903. Lee JH, Jin Y, He G, Zeng SX, Wang YV, Wahl GM, Lu H. PMID: 22556425.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell. 2012 Feb 03; 10(2):183-97. Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM. PMID: 22305568.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    36. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene. 2012 Nov 08; 31(45):4789-97. Wade M, Li YC, Matani AS, Braun SM, Milanesi F, Rodewald LW, Wahl GM. PMID: 22266850.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    37. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. PMID: 21724834.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    38. p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer. 2011 Apr; 2(4):404-19. Spike BT, Wahl GM. PMID: 21779509.
      View in: PubMed   Mentions:
    39. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22745-50. Mizuno H, Spike BT, Wahl GM, Levine AJ. PMID: 21149740.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    40. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16; 18(5):411-22. Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. PMID: 21075307.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    41. The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol. 2010 May; 20(5):299-309. Wade M, Wang YV, Wahl GM. PMID: 20172729.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    42. Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo. . 2009 Nov 01; 8(21):3443-4. Wang YV, Wade M, Wahl GM. PMID: 19838055.
      View in: PubMed   Mentions:
    43. The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol. 2009 Oct; 219(2):263-74. Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl GM, Nister M, Weinberg WC. PMID: 19718706.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    44. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009 Aug 27; 460(7259):1140-4. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Izpisúa Belmonte JC. PMID: 19668186.
      View in: PubMed   Mentions: 496     Fields:    Translation:HumansAnimalsCells
    45. Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell. 2009 Jul 07; 16(1):33-43. Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. PMID: 19573810.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    46. Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res. 2009 Jan; 7(1):1-11. Wade M, Wahl GM. PMID: 19147532.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    47. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. . 2008 Jul 01; 7(13):1973-82. Wade M, Rodewald LW, Espinosa JM, Wahl GM. PMID: 18604177.
      View in: PubMed   Mentions:
    48. Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12365-70. Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. PMID: 17640893.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    49. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Int J Biochem Cell Biol. 2007; 39(7-8):1476-82. Toledo F, Wahl GM. PMID: 17499002.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    50. Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 2007 Feb; 27(4):1425-32. Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM. PMID: 17158931.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    51. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer. 2006 Dec; 6(12):909-23. Toledo F, Wahl GM. PMID: 17128209.
      View in: PubMed   Mentions: 504     Fields:    Translation:HumansAnimalsCells
    52. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006 Oct 01; 66(19):9339-44. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. PMID: 16990346.
      View in: PubMed   Mentions: 1047     Fields:    Translation:HumansAnimalsCells
    53. Hdmx modulates the outcome of p53 activation in human tumor cells. J Biol Chem. 2006 Nov 03; 281(44):33036-44. Wade M, Wong ET, Tang M, Stommel JM, Wahl GM. PMID: 16905769.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    54. RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic Acids Res. 2006 Jul 26; 34(13):e92. Toledo F, Liu CW, Lee CJ, Wahl GM. PMID: 16870721.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    55. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 2006 Jun; 13(6):927-34. Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. PMID: 16543935.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    56. Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo. Cell Death Differ. 2006 Jun; 13(6):973-83. Wahl GM. PMID: 16575406.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    57. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell. 2006 Apr; 9(4):273-85. Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM. PMID: 16616333.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    58. Explaining the biological activity of transactivation-deficient p53 variants. Nat Genet. 2006 Apr; 38(4):395-6; author reply 396-7. Tang M, Wahl GM, Nistér M. PMID: 16570054.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    59. c-Myc, genome instability, and tumorigenesis: the devil is in the details. Curr Top Microbiol Immunol. 2006; 302:169-203. Wade M, Wahl GM. PMID: 16620029.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    60. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res. 2005 Oct 04; 33(17):e147. Wong ET, Kolman JL, Li YC, Mesner LD, Hillen W, Berens C, Wahl GM. PMID: 16204450.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    61. Initiation of DNA replication at the human beta-globin 3' enhancer. Nucleic Acids Res. 2005; 33(14):4412-24. Buzina A, Aladjem MI, Kolman JL, Wahl GM, Ellis J. PMID: 16085752.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    62. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10188-93. Krummel KA, Lee CJ, Toledo F, Wahl GM. PMID: 16006521.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    63. p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene. 2005 May 19; 24(22):3563-73. Nistér M, Tang M, Zhang XQ, Yin C, Beeche M, Hu X, Enblad G, van Dyke T, Wahl GM. PMID: 15750633.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    64. A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation. . 2005 Mar; 4(3):411-7. Stommel JM, Wahl GM. PMID: 15684615.
      View in: PubMed   Mentions:
    65. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem. 2004 Dec 17; 279(51):53015-22. Thompson T, Tovar C, Yang H, Carvajal D, Vu BT, Xu Q, Wahl GM, Heimbrook DC, Vassilev LT. PMID: 15471885.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    66. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res. 2004 Jun 15; 64(12):4251-6. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR, Hoffman RM. PMID: 15205338.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    67. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J. 2004 Apr 07; 23(7):1547-56. Stommel JM, Wahl GM. PMID: 15029243.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    68. Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1. J Virol. 2003 Nov; 77(21):11767-80. Sears J, Kolman J, Wahl GM, Aiyar A. PMID: 14557661.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    69. p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell. 2002 Jun; 1(5):493-503. Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. PMID: 12124178.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    70. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell. 2002 May; 9(5):1031-44. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM. PMID: 12049739.
      View in: PubMed   Mentions: 286     Fields:    Translation:HumansCells
    71. NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against beta-lactamase-producing strains. Antimicrob Agents Chemother. 2002 May; 46(5):1262-8. Li Q, Lee JY, Castillo R, Hixon MS, Pujol C, Doppalapudi VR, Shepard HM, Wahl GM, Lobl TJ, Chan MF. PMID: 11959554.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    72. Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. . 2002 Apr; 1(6):377-84. Neuteboom ST, Karjian PL, Boyer CR, Beryt M, Pegram M, Wahl GM, Shepard HM. PMID: 12477050.
      View in: PubMed   Mentions:
    73. Replication initiation patterns in the beta-globin loci of totipotent and differentiated murine cells: evidence for multiple initiation regions. Mol Cell Biol. 2002 Jan; 22(2):442-52. Aladjem MI, Rodewald LW, Lin CM, Bowman S, Cimbora DM, Brody LL, Epner EM, Groudine M, Wahl GM. PMID: 11756541.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    74. Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011. Anticancer Drugs. 2002 Jan; 13(1):29-36. Boyer CR, Karjian PL, Wahl GM, Pegram M, Neuteboom ST. PMID: 11914638.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    75. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol. 2001 Dec; 3(12):E277-86. Wahl GM, Carr AM. PMID: 11781586.
      View in: PubMed   Mentions: 83     Fields:    Translation:Animals
    76. Coupling of mitotic chromosome tethering and replication competence in epstein-barr virus-based plasmids. Mol Cell Biol. 2001 May; 21(10):3576-88. Kanda T, Otter M, Wahl GM. PMID: 11313483.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    77. Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering. J Cell Sci. 2001 Jan; 114(Pt 1):49-58. Kanda T, Otter M, Wahl GM. PMID: 11112689.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    78. A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nat Genet. 2000 Sep; 26(1):37-43. Jimenez GS, Nister M, Stommel JM, Beeche M, Barcarse EA, Zhang XQ, O'Gorman S, Wahl GM. PMID: 10973245.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    79. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3266-71. Khan SH, Moritsugu J, Wahl GM. PMID: 10716710.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    80. Genetic instability, oncogenes, and the p53 pathway. Cold Spring Harb Symp Quant Biol. 2000; 65:511-20. Wahl G, Vafa O. PMID: 12760068.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    81. The dynamics of acentric chromosomes in cancer cells revealed by GFP-based chromosome labeling strategies. J Cell Biochem Suppl. 2000; Suppl 35:107-14. Kanda T, Wahl GM. PMID: 11389539.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    82. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses. Oncogene. 1999 Dec 13; 18(53):7656-65. Jimenez GS, Khan SH, Stommel JM, Wahl GM. PMID: 10618705.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    83. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec; 93(3):198-208. Fox RI, Herrmann ML, Frangou CG, Wahl GM, Morris RE, Strand V, Kirschbaum BJ. PMID: 10600330.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    84. How does leflunomide modulate the immune response in rheumatoid arthritis? BioDrugs. 1999 Oct; 12(4):301-15. Fox RI, Herrmann ML, Frangou CG, Wahl GM, Morris RE, Kirschbaum BJ. PMID: 18031184.
      View in: PubMed   Mentions: 4     Fields:    
    85. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature. 1999 Jul 01; 400(6739):81-3. Jimenez GS, Bryntesson F, Torres-Arzayus MI, Priestley A, Beeche M, Saito S, Sakaguchi K, Appella E, Jeggo PA, Taccioli GE, Wahl GM, Hubank M. PMID: 10403253.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    86. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 1999 Mar 15; 18(6):1660-72. Stommel JM, Marchenko ND, Jimenez GS, Moll UM, Hope TJ, Wahl GM. PMID: 10075936.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansAnimalsCells
    87. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet. 1999 Jan; 21(1):111-4. Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP. PMID: 9916802.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansCells
    88. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec; 2(6):877-85. Jiang W, Jimenez G, Wells NJ, Hope TJ, Wahl GM, Hunter T, Fukunaga R. PMID: 9885575.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    89. Genetic dissection of a mammalian replicator in the human beta-globin locus. Science. 1998 Aug 14; 281(5379):1005-9. Aladjem MI, Rodewald LW, Kolman JL, Wahl GM. PMID: 9703500.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    90. Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. Mol Cell Biol. 1998 May; 18(5):3089-100. Paulson TG, Almasan A, Brody LL, Wahl GM. PMID: 9566927.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    91. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol. 1998 Mar 26; 8(7):377-85. Kanda T, Sullivan KF, Wahl GM. PMID: 9545195.
      View in: PubMed   Mentions: 310     Fields:    Translation:HumansAnimalsCells
    92. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol. 1998 Mar 23; 140(6):1307-20. Shimizu N, Itoh N, Utiyama H, Wahl GM. PMID: 9508765.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    93. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res. 1998 Feb 01; 58(3):396-401. Khan SH, Wahl GM. PMID: 9458079.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    94. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol. 1998 Jan 29; 8(3):145-55. Aladjem MI, Spike BT, Rodewald LW, Hope TJ, Klemm M, Jaenisch R, Wahl GM. PMID: 9443911.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansCells
    95. Mapping replication fork direction by leading strand analysis. Methods. 1997 Nov; 13(3):281-92. Aladjem MI, Wahl GM. PMID: 9441854.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    96. Mouse engineering. Science. 1997 Aug 22; 277(5329):1025. O'Gorman S, Wahl GM. PMID: 9289845.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    97. Five years of work-related injuries and fatalities in Minnesota. Agriculture: a high-risk industry. Minn Med. 1997 Aug; 80(8):29-32. Brown M, Parker D, Seeland E, Boyle D, Wahl G. PMID: 9265823.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    98. p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression. Oncogene. 1997 Jul 17; 15(3):337-45. Linke SP, Harris MP, Neugebauer SE, Clarkin KC, Shepard HM, Maneval DC, Wahl GM. PMID: 9233768.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    99. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res. 1997 Mar 15; 57(6):1013-9. Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. PMID: 9067261.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    100. p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation. Cancer Res. 1997 Mar 15; 57(6):1171-9. Linke SP, Clarkin KC, Wahl GM. PMID: 9067289.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    101. Positive selection of FLP-mediated unequal sister chromatid exchange products in mammalian cells. Mol Cell Biol. 1997 Feb; 17(2):857-61. Aladjem MI, Brody LL, O'Gorman S, Wahl GM. PMID: 9001240.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    102. Maintaining genetic stability through TP53 mediated checkpoint control. Cancer Surv. 1997; 29:183-219. Wahl GM, Linke SP, Paulson TG, Huang LC. PMID: 9338102.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    103. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14106-11. Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl GM, Bradley A. PMID: 8943068.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    104. Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer. Cancer Res. 1996 Sep 01; 56(17):4021-6. Paulson TG, Wright FA, Parker BA, Russack V, Wahl GM. PMID: 8752173.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    105. p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res. 1996 Jul 01; 56(13):2940-4. Huang LC, Clarkin KC, Wahl GM. PMID: 8674045.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    106. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4827-32. Huang LC, Clarkin KC, Wahl GM. PMID: 8643488.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    107. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 1996 Apr 15; 10(8):934-47. Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM. PMID: 8608941.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    108. Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. Nat Genet. 1996 Jan; 12(1):65-71. Shimizu N, Kanda T, Wahl GM. PMID: 8528254.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    109. Participation of the human beta-globin locus control region in initiation of DNA replication. Science. 1995 Nov 03; 270(5237):815-9. Aladjem MI, Groudine M, Brody LL, Dieken ES, Fournier RE, Wahl GM, Epner EM. PMID: 7481774.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    110. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10436-40. Li W, Fan J, Hochhauser D, Banerjee D, Zielinski Z, Almasan A, Yin Y, Kelly R, Wahl GM, Bertino JR. PMID: 7479800.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    111. Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene. Mol Cell Biol. 1995 Aug; 15(8):4136-48. Kelly RE, DeRose ML, Draper BW, Wahl GM. PMID: 7623808.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    112. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5436-40. Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, Bertino JR, Wahl GM. PMID: 7777526.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    113. Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Cancer Metastasis Rev. 1995 Mar; 14(1):59-73. Almasan A, Linke SP, Paulson TG, Huang LC, Wahl GM. PMID: 7606822.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    114. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 1994 Nov 01; 8(21):2540-51. Di Leonardo A, Linke SP, Clarkin K, Wahl GM. PMID: 7958916.
      View in: PubMed   Mentions: 255     Fields:    Translation:HumansCells
    115. Pharmacokinetics of hydroxyurea in nude mice. Anticancer Drugs. 1994 Oct; 5(5):573-8. Van den Berg CL, McGill JR, Kuhn JG, Walsh JT, De La Cruz PS, Davidson KK, Wahl GM, Von Hoff DD. PMID: 7858290.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    116. Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6674-8. Eckhardt SG, Dai A, Davidson KK, Forseth BJ, Wahl GM, Von Hoff DD. PMID: 8022834.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    117. Chromosomal localization of the human retinoid X receptors. Genomics. 1994 Apr; 20(3):397-403. Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM. PMID: 8034312.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    118. Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci. Mol Cell Biol. 1993 May; 13(5):2971-81. Carroll SM, DeRose ML, Kolman JL, Nonet GH, Kelly RE, Wahl GM. PMID: 8474455.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    119. Introduction of YACs containing a putative mammalian replication origin into mammalian cells can generate structures that replicate autonomously. Somat Cell Mol Genet. 1993 Mar; 19(2):171-92. Nonet GH, Wahl GM. PMID: 8511674.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    120. Molecular dissection of an extrachromosomal amplicon reveals a circular structure consisting of an imperfect inverted duplication. Genomics. 1993 Mar; 15(3):543-58. Nonet GH, Carroll SM, DeRose ML, Wahl GM. PMID: 8468049.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    121. Effect of genomic position on amplification of the DFR1 gene in Saccharomyces cerevisiae. Adv Exp Med Biol. 1993; 338:545-50. Barclay BJ, Ondrusek NK, Wildenhain YD, Huang T, Carlone RL, Clement JM, Wahl GM. PMID: 8304177.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    122. Cell cycle regulation of gene amplification. Cold Spring Harb Symp Quant Biol. 1993; 58:655-67. Di Leonardo A, Linke SP, Yin Y, Wahl GM. PMID: 7956082.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    123. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell. 1992 Sep 18; 70(6):937-48. Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM. PMID: 1525830.
      View in: PubMed   Mentions: 251     Fields:    Translation:HumansCells
    124. Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8165-9. Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, Van Devanter DR, Wahl GM. PMID: 1518843.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    125. Molecular dissection of mammalian gene amplification: new mechanistic insights revealed by analyses of very early events. Mutat Res. 1992 May; 276(3):199-224. Windle BE, Wahl GM. PMID: 1374515.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    126. A branching process model of gene amplification following chromosome breakage. Mutat Res. 1992 May; 276(3):225-39. Kimmel M, Axelrod DE, Wahl GM. PMID: 1374516.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    127. c-myc oncogene copy number in squamous carcinoma of the head and neck. Am J Otolaryngol. 1992 May-Jun; 13(3):168-71. Haughey BH, von Hoff DD, Windle BE, Wahl GM, Mock PM. PMID: 1626617.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    128. Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells. Cancer Res. 1991 Dec 01; 51(23 Pt 1):6273-9. Von Hoff DD, Waddelow T, Forseth B, Davidson K, Scott J, Wahl G. PMID: 1682044.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    129. Replication timing control can be maintained in extrachromosomally amplified genes. Mol Cell Biol. 1991 Sep; 11(9):4779-85. Carroll SM, Trotter J, Wahl GM. PMID: 1678857.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    130. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science. 1991 Mar 15; 251(4999):1351-5. O'Gorman S, Fox DT, Wahl GM. PMID: 1900642.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    131. A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev. 1991 Feb; 5(2):160-74. Windle B, Draper BW, Yin YX, O'Gorman S, Wahl GM. PMID: 1995414.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    132. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs. 1991 Feb; 2(1):11-25. Benner SE, Wahl GM, Von Hoff DD. PMID: 1720337.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    133. Chromosomal destabilization during gene amplification. Mol Cell Biol. 1990 Jun; 10(6):3056-66. Ruiz JC, Wahl GM. PMID: 2188107.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    134. Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplification scheme. Gene. 1990 Apr 30; 89(1):117-22. Barringer KJ, Orgel L, Wahl G, Gingeras TR. PMID: 2197176.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    135. Recent progress in understanding mechanisms of mammalian DNA amplification. Cell. 1989 Jun 16; 57(6):901-8. Stark GR, Debatisse M, Giulotto E, Wahl GM. PMID: 2661014.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    136. The importance of circular DNA in mammalian gene amplification. Cancer Res. 1989 Mar 15; 49(6):1333-40. Wahl GM. PMID: 2647287.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    137. Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. Mol Cell Biol. 1989 Jan; 9(1):109-15. Ruiz JC, Choi KH, von Hoff DD, Roninson IB, Wahl GM. PMID: 2648129.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    138. Formation of an inverted duplication can be an initial step in gene amplification. Mol Cell Biol. 1988 Oct; 8(10):4302-13. Ruiz JC, Wahl GM. PMID: 3185551.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    139. Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4804-8. Von Hoff DD, Needham-VanDevanter DR, Yucel J, Windle BE, Wahl GM. PMID: 3164477.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    140. Double minute chromosomes can be produced from precursors derived from a chromosomal deletion. Mol Cell Biol. 1988 Apr; 8(4):1525-33. Carroll SM, DeRose ML, Gaudray P, Moore CM, Needham-Vandevanter DR, Von Hoff DD, Wahl GM. PMID: 2898098.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    141. Mapping and sequencing of the dihydrofolate reductase gene (DFR1) of Saccharomyces cerevisiae. Gene. 1988 Mar 31; 63(2):175-85. Barclay BJ, Huang T, Nagel MG, Misener VL, Game JC, Wahl GM. PMID: 2838386.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    142. Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol Cell Biol. 1987 May; 7(5):1740-50. Carroll SM, Gaudray P, De Rose ML, Emery JF, Meinkoth JL, Nakkim E, Subler M, Von Hoff DD, Wahl GM. PMID: 2885742.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    143. Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. Mol Cell Biol. 1987 Apr; 7(4):1415-24. Meinkoth J, Killary AM, Fournier RE, Wahl GM. PMID: 3600632.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    144. Escherichia coli aspartate transcarbamylase: a novel marker for studies of gene amplification and expression in mammalian cells. Mol Cell Biol. 1986 Sep; 6(9):3050-8. Ruiz JC, Wahl GM. PMID: 3537729.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    145. New RNA species is produced by alternate polyadenylation following rearrangement associated with CAD gene amplification. Somat Cell Mol Genet. 1986 Jul; 12(4):339-50. Meinkoth JL, Legouy E, Brison O, Wahl GM. PMID: 2426798.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    146. Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase. J Biol Chem. 1986 May 15; 261(14):6285-92. Gaudray P, Trotter J, Wahl GM. PMID: 3700393.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    147. Effect of chromosomal position on amplification of transfected genes in animal cells. Nature. 1984 Feb 9-15; 307(5951):516-20. Wahl GM, Robert de Saint Vincent B, DeRose ML. PMID: 6694743.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    148. Gene amplification. Annu Rev Biochem. 1984; 53:447-91. Stark GR, Wahl GM. PMID: 6383198.
      View in: PubMed   Mentions: 187     Fields:    Translation:AnimalsCells
    149. Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells. Mol Cell Biol. 1983 Nov; 3(11):2066-75. Wahl GM, Vitto L, Rubnitz J. PMID: 6318080.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    150. Derivatization of unprotected polynucleotides. Nucleic Acids Res. 1983 Sep 24; 11(18):6513-29. Chu BC, Wahl GM, Orgel LE. PMID: 6622259.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    151. Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):2002-6. de Saint Vincent BR, Wahl GM. PMID: 6132383.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    152. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol. 1982 Nov; 2(11):1372-87. Folger KR, Wong EA, Wahl G, Capecchi MR. PMID: 6298598.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    153. Patents and literature. Appl Biochem Biotechnol. 1982 May; 7(3):217-30. Kit M, Narasimhan MJ, Anderson JA, Zimmermann U, Pilwat G, Furuya T, Tani Y, Kolehmainen SE, Tarkkanen V, Barrett SP, Gestrelius SM, Belloc A, Florent J, Lunel J, Palla J, Mancy D, Bailey JE, Cho YK, Mouri T, Kayama H, Foley SE, Oriel PJ, Epstein CC, Kimura K, Spraker PW, Ljungdahl LG, Wieget JK, Levine DW, Thilly WG, Wang DI, Wong JS, Eisinger MG, Young FE, Wilson GA, Mottice SL, Green H, Kehinde O, Buhler M, Olofsson M, Osseux PF, Degen L, Branduzzi P, Olivieri R, Cimini N, Kang KS, Veeder GT, Latymer Z, Andersen G, Drobot W, Monsheimer R, Pfleiderer E, Hidaka H, Kohno T, Eida T, Weisrock WP, Stevens VC, Takezawa K, Hiratani H, Wandrey C, Wichmann R, Leuchtenberger W, Kula M, Buckmann A, Troller J, Koshugi J, Frommer W, Muller L, Schmidt D, Puls W, Krause H, Heber U, Cohen SN, Wahl GM, Stark GR, Collins J, Hohn B, Sugano H, Matsui Y. PMID: 24234232.
      View in: PubMed   Mentions:    Fields:    
    154. Properties of dispersed, highly repeated DNA within and near the hamster CAD gene. Mol Cell Biol. 1982 Mar; 2(3):302-7. Padgett RA, Wahl GM, Stark GR. PMID: 6180303.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    155. Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. Mol Cell Biol. 1982 Mar; 2(3):293-301. Padgett RA, Wahl GM, Stark GR. PMID: 6125880.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    156. Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Mol Cell Biol. 1982 Mar; 2(3):308-19. Wahl GM, Vitto L, Padgett RA, Stark GR. PMID: 6180304.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    157. The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker. Cell. 1981 Dec; 27(2 Pt 1):267-77. de Saint Vincent BR, Delbrück S, Eckhart W, Meinkoth J, Vitto L, Wahl G. PMID: 6277500.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    158. Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells. J Biol Chem. 1979 Sep 10; 254(17):8679-89. Wahl GM, Padgett RA, Stark GR. PMID: 381311.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    159. N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. J Biol Chem. 1979 Feb 10; 254(3):974-80. Padgett RA, Wahl GM, Coleman PF, Stark GR. PMID: 762107.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    160. Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods Enzymol. 1979; 68:220-42. Alwine JC, Kemp DJ, Parker BA, Reiser J, Renart J, Stark GR, Wahl GM. PMID: 94421.
      View in: PubMed   Mentions: 232     Fields:    Translation:Cells
    161. Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell. 1975 Nov; 6(3):269-77. Capecchi MR, Hughes SH, Wahl GM. PMID: 802681.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    162. Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol. 1975 Apr; 85(2 Pt 1):307-20. Wahl GM, Hughes SH, Capecchi MR. PMID: 47331.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    Geoffrey's Networks
    Concepts (610)
    Derived automatically from this person's publications.
    _
    Co-Authors (32)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _