Geoffrey Wahl

Title(s)Adjunct Professor, Molecular Biology
SchoolAcademic Aff
Address9500 Gilman Drive #0932
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunity
    NIH/NCI R01CA240909Mar 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Combining single cell approaches and a developmental perspective to discover stem cell control circuits and the cellular and molecular bases of cancer heterogeneity
    NIH/NCI R35CA197687Aug 1, 2015 - Jul 31, 2022
    Role: Principal Investigator
    High throughput screen for inhibitors of the mdm2/mdmx interaction
    NIH/NIMH R03MH089489Feb 1, 2010 - Nov 30, 2011
    Role: Principal Investigator
    Mouse Models to Elucidate p53 Regulatory Mechanisms
    NIH/NCI R01CA100845Apr 15, 2003 - Mar 31, 2009
    Role: Principal Investigator
    NIH/NCRR S10RR013692Feb 16, 1999 - Feb 15, 2000
    Role: Principal Investigator
    NIH/NIGMS R01GM051104Aug 1, 1993 - Jul 31, 1998
    Role: Principal Investigator
    Mechanisms of Genetic Instability and Tumor Suppression
    NIH/NCI R01CA061449Jul 1, 1993 - Sep 27, 2006
    Role: Principal Investigator
    NIH/NCI R01CA048405Aug 1, 1988 - May 31, 1999
    Role: Principal Investigator
    NIH/NCI U01CA048405Aug 1, 1988 - Jul 31, 1995
    Role: Principal Investigator
    NIH/NCI R13CA049116Jul 1, 1988 - Jun 30, 1989
    Role: Principal Investigator
    Salk Institute Cancer Training Grant
    NIH/NCI T32CA009370Sep 1, 1980 - Sep 28, 2011
    Role: Co-Principal Investigator
    NIH/NIGMS R01GM027754Apr 1, 1980 - Mar 31, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. Cell Rep. 2020 Jun 09; 31(10):107742. Christin JR, Wang C, Chung CY, Liu Y, Dravis C, Tang W, Oktay MH, Wahl GM, Guo W. PMID: 32521267.
      View in: PubMed   Mentions:    Fields:    
    2. Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders. Proc Natl Acad Sci U S A. 2020 Jun 02; 117(22):12121-12130. Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. PMID: 32424096.
      View in: PubMed   Mentions:    Fields:    
    3. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020 04 03; 368(6486):85-89. Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. PMID: 32241947.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis. Front Physiol. 2020; 11:88. DelGiorno KE, Naeem RF, Fang L, Chung CY, Ramos C, Luhtala N, O'Connor C, Hunter T, Manor U, Wahl GM. PMID: 32116793.
      View in: PubMed   Mentions:
    5. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Sci Alliance. 2020 Jan; 3(1). Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW. PMID: 31959624.
      View in: PubMed   Mentions:    Fields:    
    6. DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. Cell Rep. 2019 12 10; 29(11):3448-3459.e6. Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC. PMID: 31825828.
      View in: PubMed   Mentions: 2     Fields:    
    7. Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships. Cell Rep. 2019 10 08; 29(2):495-510.e6. Chung CY, Ma Z, Dravis C, Preissl S, Poirion O, Luna G, Hou X, Giraddi RR, Ren B, Wahl GM. PMID: 31597106.
      View in: PubMed   Mentions: 3     Fields:    
    8. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 05; 569(7754):131-135. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 30996350.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    9. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell. 2018 09 10; 34(3):466-482.e6. Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. PMID: 30174241.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    10. Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development. Cell Rep. 2018 08 07; 24(6):1653-1666.e7. Giraddi RR, Chung CY, Heinz RE, Balcioglu O, Novotny M, Trejo CL, Dravis C, Hagos BM, Mehrabad EM, Rodewald LW, Hwang JY, Fan C, Lasken R, Varley KE, Perou CM, Wahl GM, Spike BT. PMID: 30089273.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM. PMID: 29211796.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. NPJ Breast Cancer. 2017; 3:16. Trejo CL, Luna G, Dravis C, Spike BT, Wahl GM. PMID: 28649656.
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    13. Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer. 2017; 3:14. Wahl GM, Spike BT. PMID: 28649654.
      View in: PubMed   Mentions:
    14. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    15. [Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Aug 18; 48(4):697-701. Wang Y, Barry O, Wahl G, Chen B, Lin Y. PMID: 29263516.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte JC. PMID: 26899176.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    17. [Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Feb 18; 48(1):697-701. Wang Y, Barry O, Wahl G, Chen B, Lin Y. PMID: 27538155.
      View in: PubMed   Mentions:    Fields:    
    18. Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep. 2015 Sep 29; 12(12):2035-48. Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM. PMID: 26365194.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    19. The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 09; 55(9):1387-96. Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. PMID: 26310697.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila). 2015 Sep; 8(9):762-4. Rozhok AI, Wahl GM, DeGregori J. PMID: 26122457.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    21. Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat. 2015 Jan; 149(2):425-37. Pfefferle AD, Spike BT, Wahl GM, Perou CM. PMID: 25575446.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    22. A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11; 9(5):1946-1958. Li YC, Rodewald LW, Hoppmann C, Wong ET, Lebreton S, Safar P, Patek M, Wang L, Wertman KF, Wahl GM. PMID: 25464845.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    23. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. PMID: 25259922.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimalsCells
    24. CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports. 2014 Apr 08; 2(4):427-39. Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl GM, Gray PC. PMID: 24749068.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    25. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013 Nov 12; 14(11):R125. Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. PMID: 24220145.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    26. AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol. 2014 Jan; 34(2):148-57. He G, Zhang YW, Lee JH, Zeng SX, Wang YV, Luo Z, Dong XC, Viollet B, Wahl GM, Lu H. PMID: 24190973.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    27. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem. 2013 Sep 06; 288(36):26301-10. Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl GM, Rathmell WK. PMID: 23893409.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    28. Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia. 2013 Jun; 18(2):209-19. Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM, Eaves CJ. PMID: 23624881.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6991-6. Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl GM. PMID: 23559372.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    30. Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. PLoS One. 2013; 8(3):e58395. Green JL, Bauer M, Yum KW, Li YC, Cox ML, Willert K, Wahl GM. PMID: 23516471.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 2013 Feb; 13(2):83-96. Wade M, Li YC, Wahl GM. PMID: 23303139.
      View in: PubMed   Mentions: 295     Fields:    Translation:HumansAnimals
    32. What a difference a phosphate makes: life or death decided by a single amino acid in MDM2. Cancer Cell. 2012 May 15; 21(5):595-6. Li YC, Wahl GM. PMID: 22624708.
      View in: PubMed   Mentions: 1     Fields:    
    33. Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3? inactivation of MDMX protein. J Biol Chem. 2012 Jun 15; 287(25):20898-903. Lee JH, Jin Y, He G, Zeng SX, Wang YV, Wahl GM, Lu H. PMID: 22556425.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    34. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell. 2012 Feb 03; 10(2):183-97. Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM. PMID: 22305568.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    35. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene. 2012 Nov 08; 31(45):4789-97. Wade M, Li YC, Matani AS, Braun SM, Milanesi F, Rodewald LW, Wahl GM. PMID: 22266850.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. PMID: 21724834.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    37. p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer. 2011 Apr; 2(4):404-19. Spike BT, Wahl GM. PMID: 21779509.
      View in: PubMed   Mentions:
    38. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22745-50. Mizuno H, Spike BT, Wahl GM, Levine AJ. PMID: 21149740.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    39. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16; 18(5):411-22. Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. PMID: 21075307.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    40. The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol. 2010 May; 20(5):299-309. Wade M, Wang YV, Wahl GM. PMID: 20172729.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansAnimalsCells
    41. Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo. Cell Cycle. 2009 Nov 01; 8(21):3443-4. Wang YV, Wade M, Wahl GM. PMID: 19838055.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    42. The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol. 2009 Oct; 219(2):263-74. Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl GM, Nister M, Weinberg WC. PMID: 19718706.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    43. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009 Aug 27; 460(7259):1140-4. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Izpisúa Belmonte JC. PMID: 19668186.
      View in: PubMed   Mentions: 483     Fields:    Translation:HumansAnimalsCells
    44. Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell. 2009 Jul 07; 16(1):33-43. Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. PMID: 19573810.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    45. Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res. 2009 Jan; 7(1):1-11. Wade M, Wahl GM. PMID: 19147532.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    46. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle. 2008 Jul 01; 7(13):1973-82. Wade M, Rodewald LW, Espinosa JM, Wahl GM. PMID: 18604177.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    47. Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12365-70. Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. PMID: 17640893.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    48. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Int J Biochem Cell Biol. 2007; 39(7-8):1476-82. Toledo F, Wahl GM. PMID: 17499002.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    49. Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 2007 Feb; 27(4):1425-32. Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM. PMID: 17158931.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    50. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer. 2006 Dec; 6(12):909-23. Toledo F, Wahl GM. PMID: 17128209.
      View in: PubMed   Mentions: 481     Fields:    Translation:HumansAnimalsCells
    51. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006 Oct 01; 66(19):9339-44. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. PMID: 16990346.
      View in: PubMed   Mentions: 983     Fields:    Translation:HumansAnimalsCells
    52. Hdmx modulates the outcome of p53 activation in human tumor cells. J Biol Chem. 2006 Nov 03; 281(44):33036-44. Wade M, Wong ET, Tang M, Stommel JM, Wahl GM. PMID: 16905769.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    53. RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic Acids Res. 2006 Jul 26; 34(13):e92. Toledo F, Liu CW, Lee CJ, Wahl GM. PMID: 16870721.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    54. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 2006 Jun; 13(6):927-34. Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. PMID: 16543935.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    55. Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo. Cell Death Differ. 2006 Jun; 13(6):973-83. Wahl GM. PMID: 16575406.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    56. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell. 2006 Apr; 9(4):273-85. Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM. PMID: 16616333.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    57. Explaining the biological activity of transactivation-deficient p53 variants. Nat Genet. 2006 Apr; 38(4):395-6; author reply 396-7. Tang M, Wahl GM, Nistér M. PMID: 16570054.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    58. c-Myc, genome instability, and tumorigenesis: the devil is in the details. Curr Top Microbiol Immunol. 2006; 302:169-203. Wade M, Wahl GM. PMID: 16620029.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    59. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res. 2005 Oct 04; 33(17):e147. Wong ET, Kolman JL, Li YC, Mesner LD, Hillen W, Berens C, Wahl GM. PMID: 16204450.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    60. Initiation of DNA replication at the human beta-globin 3' enhancer. Nucleic Acids Res. 2005; 33(14):4412-24. Buzina A, Aladjem MI, Kolman JL, Wahl GM, Ellis J. PMID: 16085752.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    61. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10188-93. Krummel KA, Lee CJ, Toledo F, Wahl GM. PMID: 16006521.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    62. p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene. 2005 May 19; 24(22):3563-73. Nistér M, Tang M, Zhang XQ, Yin C, Beeche M, Hu X, Enblad G, van Dyke T, Wahl GM. PMID: 15750633.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    63. A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation. Cell Cycle. 2005 Mar; 4(3):411-7. Stommel JM, Wahl GM. PMID: 15684615.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    64. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem. 2004 Dec 17; 279(51):53015-22. Thompson T, Tovar C, Yang H, Carvajal D, Vu BT, Xu Q, Wahl GM, Heimbrook DC, Vassilev LT. PMID: 15471885.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    65. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res. 2004 Jun 15; 64(12):4251-6. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR, Hoffman RM. PMID: 15205338.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    66. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J. 2004 Apr 07; 23(7):1547-56. Stommel JM, Wahl GM. PMID: 15029243.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    67. Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1. J Virol. 2003 Nov; 77(21):11767-80. Sears J, Kolman J, Wahl GM, Aiyar A. PMID: 14557661.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
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