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John Ravits

Title(s)Professor Of Clinical, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Yale University, New Haven, CTBA05/1975English
    Mayo School of Medicine, Rochester, MNMD06/1979Medicine
    University California (UC) San Diego, San Diego, CAResident06/1983Neurology
    Brigham & Womens Hospital, Boston, MAFellow06/1984Clinical Neurophysiology
    NINDS, NIH, Bethesda, MDFellow05/1986Clin Neurophys/Neuromuscular
    Collapse Awards and Honors
    American Academy of Neurology2017Sheila Essey Award for ALS Research
    Best Doctors, Inc2010  - presBest Doctors in America
    University of Washington2009AOA Volunteer Clinical Faculty of the Year

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Developing ASO Therapy for Repeat Expanded C9orf72 ALS-FTD
    NIH/NINDS R01NS088578Jul 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Microgenomic Studies of ALS
    NIH/NINDS R21NS051738Jan 1, 2006 - Dec 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. N Engl J Med. 2020 07 09; 383(2):109-119. Miller T, Cudkowicz M, Shaw PJ, Andersen PM, Atassi N, Bucelli RC, Genge A, Glass J, Ladha S, Ludolph AL, Maragakis NJ, McDermott CJ, Pestronk A, Ravits J, Salachas F, Trudell R, Van Damme P, Zinman L, Bennett CF, Lane R, Sandrock A, Runz H, Graham D, Houshyar H, McCampbell A, Nestorov I, Chang I, McNeill M, Fanning L, Fradette S, Ferguson TA. PMID: 32640130.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    2. Understanding the needs of people with ALS: a national survey of patients and caregivers. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Aug; 21(5-6):355-363. Brizzi KT, Bridges JFP, Yersak J, Balas C, Thakur N, Galvin M, Hardiman O, Heatwole C, Ravits J, Simmons Z, Bruijn L, Chan J, Bedlack R, Berry JD. PMID: 32396393.
      View in: PubMed   Mentions:    Fields:    
    3. Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS. Neurology. 2020 07 07; 95(1):e59-e69. Benatar M, Zhang L, Wang L, Granit V, Statland J, Barohn R, Swenson A, Ravits J, Jackson C, Burns TM, Trivedi J, Pioro EP, Caress J, Katz J, McCauley JL, Rademakers R, Malaspina A, Ostrow LW, Wuu J. PMID: 32385188.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020 04 20; 11(1):1958. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. PMID: 32312984.
      View in: PubMed   Mentions:    Fields:    
    5. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nat Neurosci. 2020 05; 23(5):615-624. Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, Da Cruz S, Lagier-Tourenne C, Cleveland DW. PMID: 32284607.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    6. Primary lateral sclerosis: consensus diagnostic criteria. J Neurol Neurosurg Psychiatry. 2020 04; 91(4):373-377. Turner MR, Barohn RJ, Corcia P, Fink JK, Harms MB, Kiernan MC, Ravits J, Silani V, Simmons Z, Statland J, van den Berg LH, Mitsumoto H. PMID: 32029539.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020 Jan 28; 11(1):550. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. PMID: 31992716.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology. Sci Transl Med. 2019 12 18; 11(523). Reichenstein I, Eitan C, Diaz-Garcia S, Haim G, Magen I, Siany A, Hoye ML, Rivkin N, Olender T, Toth B, Ravid R, Mandelbaum AD, Yanowski E, Liang J, Rymer JK, Levy R, Beck G, Ainbinder E, Farhan SMK, Lennox KA, Bode NM, Behlke MA, Möller T, Saxena S, Moreno CAM, Costaguta G, van Eijk KR, Phatnani H, Al-Chalabi A, Basak AN, van den Berg LH, Hardiman O, Landers JE, Mora JS, Morrison KE, Shaw PJ, Veldink JH, Pfaff SL, Yizhar O, Gross C, Brown RH, Ravits JM, Harms MB, Miller TM, Hornstein E. PMID: 31852800.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia. Cell Rep. 2019 10 29; 29(5):1164-1177.e5. Tam OH, Rozhkov NV, Shaw R, Kim D, Hubbard I, Fennessey S, Propp N, Fagegaltier D, Harris BT, Ostrow LW, Phatnani H, Ravits J, Dubnau J, Gale Hammell M. PMID: 31665631.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Pathogenic Mechanisms and Therapy Development for C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia. Neurotherapeutics. 2019 10; 16(4):1115-1132. Jiang J, Ravits J. PMID: 31667754.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Predicting disease specific spinal motor neurons and glia in sporadic ALS. Neurobiol Dis. 2019 10; 130:104523. Dachet F, Liu J, Ravits J, Song F. PMID: 31276795.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest. 2019 05 21; 129(8):3103-3120. Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H. PMID: 31112137.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Antisense RNA foci are associated with nucleoli and TDP-43 mislocalization in C9orf72-ALS/FTD: a quantitative study. Acta Neuropathol. 2019 03; 137(3):527-530. Aladesuyi Arogundade O, Stauffer JE, Saberi S, Diaz-Garcia S, Malik S, Basilim H, Rodriguez MJ, Ohkubo T, Ravits J. PMID: 30666413.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019 02; 22(2):180-190. Melamed Z, López-Erauskin J, Baughn MW, Zhang O, Drenner K, Sun Y, Freyermuth F, McMahon MA, Beccari MS, Artates JW, Ohkubo T, Rodriguez M, Lin N, Wu D, Bennett CF, Rigo F, Da Cruz S, Ravits J, Lagier-Tourenne C, Cleveland DW. PMID: 30643298.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    15. TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates. Nat Neurosci. 2019 01; 22(1):65-77. Laferrière F, Maniecka Z, Pérez-Berlanga M, Hruska-Plochan M, Gilhespy L, Hock EM, Wagner U, Afroz T, Boersema PJ, Barmettler G, Foti SC, Asi YT, Isaacs AM, Al-Amoudi A, Lewis A, Stahlberg H, Ravits J, De Giorgi F, Ichas F, Bezard E, Picotti P, Lashley T, Polymenidou M. PMID: 30559480.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis. Mob DNA. 2018; 9:35. Pereira GC, Sanchez L, Schaughency PM, Rubio-Roldán A, Choi JA, Planet E, Batra R, Turelli P, Trono D, Ostrow LW, Ravits J, Kazazian HH, Wheelan SJ, Heras SR, Mayer J, García-Pérez JL, Goodier JL. PMID: 30564290.
      View in: PubMed   Mentions:
    17. Clinical Reasoning: A 22-year-old man presenting with headache and right leg jerks. Neurology. 2018 11 06; 91(19):891-895. Schupper AJ, McGehrin K, Ravits J, Lee D. PMID: 30397040.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins. Mol Neurodegener. 2018 08 02; 13(1):39. Mayer J, Harz C, Sanchez L, Pereira GC, Maldener E, Heras SR, Ostrow LW, Ravits J, Batra R, Meese E, García-Pérez JL, Goodier JL. PMID: 30068350.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis. Neurobiol Dis. 2018 11; 119:26-40. Nonneman A, Criem N, Lewandowski SA, Nuyts R, Thal DR, Pfrieger FW, Ravits J, Van Damme P, Zwijsen A, Van Den Bosch L, Robberecht W. PMID: 30010003.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS. Acta Neuropathol. 2018 09; 136(3):405-423. Krach F, Batra R, Wheeler EC, Vu AQ, Wang R, Hutt K, Rabin SJ, Baughn MW, Libby RT, Diaz-Garcia S, Stauffer J, Pirie E, Saberi S, Rodriguez M, Madrigal AA, Kohl Z, Winner B, Yeo GW, Ravits J. PMID: 29881994.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    21. Elongator subunit 3 (ELP3) modifies ALS through tRNA modification. Hum Mol Genet. 2018 04 01; 27(7):1276-1289. Bento-Abreu A, Jager G, Swinnen B, Rué L, Hendrickx S, Jones A, Staats KA, Taes I, Eykens C, Nonneman A, Nuyts R, Timmers M, Silva L, Chariot A, Nguyen L, Ravits J, Lemmens R, Cabooter D, Van Den Bosch L, Van Damme P, Al-Chalabi A, Bystrom A, Robberecht W. PMID: 29415125.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 2018 03 21; 97(6):1268-1283.e6. Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A, Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L, Moreno CAM, Kamalakaran S, Goldstein DB, Gitler AD, Harris T, Myers RM, Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC, Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E, Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J, Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C, Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A, Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH, van den Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE. PMID: 29566793.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    23. Mexiletine for muscle cramps in amyotrophic lateral sclerosis: A randomized, double-blind crossover trial. Muscle Nerve. 2018 Mar 06. Oskarsson B, Moore D, Mozaffar T, Ravits J, Wiedau-Pazos M, Parziale N, Joyce NC, Mandeville R, Goyal N, Cudkowicz ME, Weiss M, Miller RG, McDonald CM. PMID: 29510461.
      View in: PubMed   Mentions: 3     Fields:    
    24. Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol. 2018 03; 135(3):459-474. Saberi S, Stauffer JE, Jiang J, Garcia SD, Taylor AE, Schulte D, Ohkubo T, Schloffman CL, Maldonado M, Baughn M, Rodriguez MJ, Pizzo D, Cleveland D, Ravits J. PMID: 29196813.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    25. Kinnier Wilson's puzzling features of amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2018 06; 89(6):657-666. Turner MR, Eisen A, Kiernan MC, Ravits J, Swash M. PMID: 29122933.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients. Mol Neurodegener. 2017 10 24; 12(1):76. Konrad C, Kawamata H, Bredvik KG, Arreguin AJ, Cajamarca SA, Hupf JC, Ravits JM, Miller TM, Maragakis NJ, Hales CM, Glass JD, Gross S, Mitsumoto H, Manfredi G. PMID: 29065921.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS). Cold Spring Harb Perspect Med. 2017 Aug 01; 7(8). Grad LI, Rouleau GA, Ravits J, Cashman NR. PMID: 28003278.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo. Mol Neurodegener. 2017 05 08; 12(1):37. Kawamata H, Peixoto P, Konrad C, Palomo G, Bredvik K, Gerges M, Valsecchi F, Petrucelli L, Ravits JM, Starkov A, Manfredi G. PMID: 28482850.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    29. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 2017 06; 133(6):907-922. Ditsworth D, Maldonado M, McAlonis-Downes M, Sun S, Seelman A, Drenner K, Arnold E, Ling SC, Pizzo D, Ravits J, Cleveland DW, Da Cruz S. PMID: 28357566.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. Misfolded SOD1 is not a primary component of sporadic ALS. Acta Neuropathol. 2017 07; 134(1):97-111. Da Cruz S, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J. PMID: 28247063.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    31. TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis. BMC Neurosci. 2017 01 25; 18(1):20. Williams SM, Khan G, Harris BT, Ravits J, Sierks MR. PMID: 28122516.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    32. Sleep Apnea in Familial Dysautonomia: A Reflection of Apnea Pathogenesis. J Clin Sleep Med. 2016 12 15; 12(12):1583-1584. Orr JE, Deacon N, Ravits J. PMID: 27855745.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal a-motoneurons in sporadic amyotrophic lateral sclerosis. Acta Neuropathol. 2017 01; 133(1):79-90. Braak H, Ludolph AC, Neumann M, Ravits J, Del Tredici K. PMID: 27757524.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. 2016 Aug 05; 353(6299):603-8. Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. PMID: 27493188.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    35. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Nat Commun. 2016 07 05; 7:12143. Kapeli K, Pratt GA, Vu AQ, Hutt KR, Martinez FJ, Sundararaman B, Batra R, Freese P, Lambert NJ, Huelga SC, Chun SJ, Liang TY, Chang J, Donohue JP, Shiue L, Zhang J, Zhu H, Cambi F, Kasarskis E, Hoon S, Ares M, Burge CB, Ravits J, Rigo F, Yeo GW. PMID: 27378374.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    36. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 05 04; 90(3):535-50. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. PMID: 27112497.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    37. Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. Acta Neuropathol Commun. 2016 Feb 18; 4:15. Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K. PMID: 26891847.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):2514-9. Sellers DL, Bergen JM, Johnson RN, Back H, Ravits JM, Horner PJ, Pun SH. PMID: 26888285.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    39. Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants. Neurol Clin. 2015 Nov; 33(4):855-76. Saberi S, Stauffer JE, Schulte DJ, Ravits J. PMID: 26515626.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    40. Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. EMBO J. 2015 Nov 03; 34(21):2633-51. Emde A, Eitan C, Liou LL, Libby RT, Rivkin N, Magen I, Reichenstein I, Oppenheim H, Eilam R, Silvestroni A, Alajajian B, Ben-Dov IZ, Aebischer J, Savidor A, Levin Y, Sons R, Hammond SM, Ravits JM, Möller T, Hornstein E. PMID: 26330466.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    41. Amyotrophic lateral sclerosis: Is the spinal fluid pathway involved in seeding and spread? Med Hypotheses. 2015 Nov; 85(5):576-83. Smith R, Myers K, Ravits J, Bowser R. PMID: 26220261.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    42. A revision of the El Escorial criteria - 2015. Amyotroph Lateral Scler Frontotemporal Degener. 2015; 16(5-6):291-2. Ludolph A, Drory V, Hardiman O, Nakano I, Ravits J, Robberecht W, Shefner J. PMID: 26121170.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    43. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science. 2015 Mar 27; 347(6229):1436-41. Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, Wimbish JR, Waite LL, Jones AL, Carulli JP, Day-Williams AG, Staropoli JF, Xin WW, Chesi A, Raphael AR, McKenna-Yasek D, Cady J, Vianney de Jong JM, Kenna KP, Smith BN, Topp S, Miller J, Gkazi A, Al-Chalabi A, van den Berg LH, Veldink J, Silani V, Ticozzi N, Shaw CE, Baloh RH, Appel S, Simpson E, Lagier-Tourenne C, Pulst SM, Gibson S, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider NA, Chung WK, Ravits JM, Glass JD, Sims KB, Van Deerlin VM, Maniatis T, Hayes SD, Ordureau A, Swarup S, Landers J, Baas F, Allen AS, Bedlack RS, Harper JW, Gitler AD, Rouleau GA, Brown R, Harms MB, Cooper GM, Harris T, Myers RM, Goldstein DB. PMID: 25700176.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansCells
    44. Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes. Ann Neurol. 2015 Jan; 77(1):100-13. Cady J, Allred P, Bali T, Pestronk A, Goate A, Miller TM, Mitra RD, Ravits J, Harms MB, Baloh RH. PMID: 25382069.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    45. An a2-Na/K ATPase/a-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration. Nat Neurosci. 2014 Dec; 17(12):1710-9. Gallardo G, Barowski J, Ravits J, Siddique T, Lingrel JB, Robertson J, Steen H, Bonni A. PMID: 25344630.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    46. Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis. Exp Neurol. 2014 Dec; 262 Pt B:121-6. Ravits J. PMID: 25108067.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    47. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. JAMA Neurol. 2014 Apr; 71(4):449-53. Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. PMID: 24535663.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    48. Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):829-32. Meyer K, Ferraiuolo L, Miranda CJ, Likhite S, McElroy S, Renusch S, Ditsworth D, Lagier-Tourenne C, Smith RA, Ravits J, Burghes AH, Shaw PJ, Cleveland DW, Kolb SJ, Kaspar BK. PMID: 24379375.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    49. Activation of microglial neuregulin1 signaling in the corticospinal tracts of ALS patients with upper motor neuron signs. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Mar; 15(1-2):77-83. Song F, Chiang P, Ravits J, Loeb JA. PMID: 24229388.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    50. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4530-9. Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. PMID: 24170860.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    51. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med. 2013 Oct 23; 5(208):208ra149. Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, Rigo F, Bennett CF, Otis TS, Svendsen CN, Baloh RH. PMID: 24154603.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansCells
    52. ALS Untangled No. 20: the Deanna protocol. Amyotroph Lateral Scler Frontotemporal Degener. 2013 May; 14(4):319-23. Fournier C, Bedlack B, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, Dimachkie M, Wang Y, Wicks P, Heywood J, Novella S, Rowland LP, Pioro E, Kinsley L, Mitchell K, Glass J, Sathornsumetee S, Kwiecinski H, Baker J, Atassi N, Forshew D, Ravits J, Conwit R, Jackson C, Sherman A, Dalton K, Tindall K, Gonzalez G, Robertson J, Phillips L, Benatar M, Sorenson E, Shoesmith C, Nash S, Maragakis N, Moore D, Caress J, Boylan K, Armon C, Grosso M, Gerecke B, Wymer J, Oskarsson B, Bowser R, Drory V, Shefner J, Lechtzin N, Leitner M, Miller R, Mitsumoto H, Levine T, Russell J, Sharma K, Saperstein D, McClusky L, MacGowan D, Licht J, Verma A, Strong M, Lomen-Hoerth C, Tandan R, Rivner M, Kolb S, Polak M, Rudnicki S, Kittrell P, Quereshi M, Sachs G, Pattee G, Weiss M, Kissel J, Goldstein J, Rothstein J, Pastula D, Gleb L, Ogino M, Rosenfeld J, Carmi E, Oster C, Barkhaus P, Valor E. PMID: 23638638.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    53. Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotroph Lateral Scler Frontotemporal Degener. 2013 May; 14 Suppl 1:5-18. Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, van den Berg LH, Ringel S. PMID: 23678876.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    54. Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis. Neurobiol Aging. 2013 Sep; 34(9):2234.e13-9. Harms MB, Cady J, Zaidman C, Cooper P, Bali T, Allred P, Cruchaga C, Baughn M, Libby RT, Pestronk A, Goate A, Ravits J, Baloh RH. PMID: 23597494.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    55. Opportunity and innovation in studying pre-symptomatic amyotrophic lateral sclerosis. Muscle Nerve. 2013 May; 47(5):629-31. Benatar M, Wuu J, Ravits J. PMID: 23494825.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    56. Controversies and priorities in amyotrophic lateral sclerosis. Lancet Neurol. 2013 Mar; 12(3):310-22. Turner MR, Hardiman O, Benatar M, Brooks BR, Chio A, de Carvalho M, Ince PG, Lin C, Miller RG, Mitsumoto H, Nicholson G, Ravits J, Shaw PJ, Swash M, Talbot K, Traynor BJ, Van den Berg LH, Veldink JH, Vucic S, Kiernan MC. PMID: 23415570.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimals
    57. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci. 2012 Nov; 15(11):1488-97. Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW. PMID: 23023293.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansAnimalsCells
    58. Aberrant neuregulin 1 signaling in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2012 Feb; 71(2):104-15. Song F, Chiang P, Wang J, Ravits J, Loeb JA. PMID: 22249457.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    59. TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread. Amyotroph Lateral Scler. 2010 May 03; 11(3):321-7. Bodansky A, Kim JM, Tempest L, Velagapudi A, Libby R, Ravits J. PMID: 20225928.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    60. No evidence of HIV pol gene in spinal cord tissues in sporadic ALS by real-time RT-PCR. Amyotroph Lateral Scler. 2010; 11(1-2):91-6. Kim YJ, Fan Y, Laurie P, Kim JM, Ravits J. PMID: 19322704.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    61. Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology. Hum Mol Genet. 2010 Jan 15; 19(2):313-28. Rabin SJ, Kim JM, Baughn M, Libby RT, Kim YJ, Fan Y, Libby RT, La Spada A, Stone B, Ravits J. PMID: 19864493.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    62. ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration. Neurology. 2009 Sep 08; 73(10):805-11. Ravits JM, La Spada AR. PMID: 19738176.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    63. Current and future directions in genomics of amyotrophic lateral sclerosis. Phys Med Rehabil Clin N Am. 2008 Aug; 19(3):461-77, viii. Ravits J, Traynor BJ. PMID: 18625410.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    64. An aggregate-inducing peripherin isoform generated through intron retention is upregulated in amyotrophic lateral sclerosis and associated with disease pathology. J Neurosci. 2008 Feb 20; 28(8):1833-40. Xiao S, Tjostheim S, Sanelli T, McLean JR, Horne P, Fan Y, Ravits J, Strong MJ, Robertson J. PMID: 18287500.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    65. Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. Lancet Neurol. 2007 Dec; 6(12):1045-53. Gordon PH, Moore DH, Miller RG, Florence JM, Verheijde JL, Doorish C, Hilton JF, Spitalny GM, MacArthur RB, Mitsumoto H, Neville HE, Boylan K, Mozaffar T, Belsh JM, Ravits J, Bedlack RS, Graves MC, McCluskey LF, Barohn RJ, Tandan R. PMID: 17980667.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansCTClinical Trials
    66. Implications of ALS focality: rostral-caudal distribution of lower motor neuron loss postmortem. Neurology. 2007 May 08; 68(19):1576-82. Ravits J, Laurie P, Fan Y, Moore DH. PMID: 17485644.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    67. Focality of upper and lower motor neuron degeneration at the clinical onset of ALS. Neurology. 2007 May 08; 68(19):1571-5. Ravits J, Paul P, Jorg C. PMID: 17485643.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    68. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol. 2007 May; 61(5):427-34. Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, Kirby J, Siddique T, Shaw PJ, Lee VM, Trojanowski JQ. PMID: 17469116.
      View in: PubMed   Mentions: 280     Fields:    Translation:Humans
    69. A4V superoxide dismutase mutation in apparently sporadic ALS resembling neuralgic amyotrophy. Amyotroph Lateral Scler. 2006 Mar; 7(1):61-3. Weiss MD, Ravits JM, Schuman N, Carter GT. PMID: 16546761.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    70. Amyotrophic lateral sclerosis microgenomics. Phys Med Rehabil Clin N Am. 2005 Nov; 16(4):909-24, viii. Ravits J, Laurie P, Stone B. PMID: 16214051.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    71. Sporadic amyotrophic lateral sclerosis: a hypothesis of persistent (non-lytic) enteroviral infection. Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Jun; 6(2):77-87. Ravits J. PMID: 16036430.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    72. Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes. Amyotroph Lateral Scler Other Motor Neuron Disord. 2003 Jun; 4(2):62-73. Andersen PM, Sims KB, Xin WW, Kiely R, O'Neill G, Ravits J, Pioro E, Harati Y, Brower RD, Levine JS, Heinicke HU, Seltzer W, Boss M, Brown RH. PMID: 14506936.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    73. Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology. 2001 Apr 10; 56(7):843-8. Miller RG, Moore DH, Gelinas DF, Dronsky V, Mendoza M, Barohn RJ, Bryan W, Ravits J, Yuen E, Neville H, Ringel S, Bromberg M, Petajan J, Amato AA, Jackson C, Johnson W, Mandler R, Bosch P, Smith B, Graves M, Ross M, Sorenson EJ, Kelkar P, Parry G, Olney R. PMID: 11294919.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
    74. Late-onset SCA2: 33 CAG repeats are sufficient to cause disease. Neurology. 2000 Aug 22; 55(4):569-72. Fernandez M, McClain ME, Martinez RA, Snow K, Lipe H, Ravits J, Bird TD, La Spada AR. PMID: 10953195.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    75. Recent advances in the treatment of neuropathies. West J Med. 1998 Apr; 168(4):268-9. Ravits J. PMID: 9584672.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    76. AAEM minimonograph #48: autonomic nervous system testing. Muscle Nerve. 1997 Aug; 20(8):919-37. Ravits JM. PMID: 9236782.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    77. Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS Study Group. Western Amyotrophic Lateral Sclerosis Study Group. Neurology. 1996 Dec; 47(6):1383-8. Miller RG, Moore D, Young LA, Armon C, Barohn RJ, Bromberg MB, Bryan WW, Gelinas DF, Mendoza MC, Neville HE, Parry GJ, Petajan JH, Ravits JM, Ringel SP, Ross MA. PMID: 8960715.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    78. Electrophysiological tests of autonomic function in patients with idiopathic autonomic failure syndromes. Muscle Nerve. 1996 Jun; 19(6):758-63. Ravits J, Hallett M, Nilsson J, Polinsky R, Dambrosia J. PMID: 8609927.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    79. Myasthenic (Eaton-Lambert) syndrome associated with pulmonary large-cell neuroendocrine carcinoma. South Med J. 1994 Nov; 87(11):1186-9. Demirer T, Ravits J, Aboulafia D. PMID: 7973914.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    80. A double-blind trial of isoniazid for essential tremor and other action tremors. Mov Disord. 1991; 6(3):253-6. Hallett M, Ravits J, Dubinsky RM, Gillespie MM, Moinfar A. PMID: 1681430.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    81. Clinical and electromyographic studies of postpoliomyelitis muscular atrophy. Muscle Nerve. 1990 Aug; 13(8):667-74. Ravits J, Hallett M, Baker M, Nilsson J, Dalakas M. PMID: 2385251.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    82. Botulinum toxin therapy in hemifacial spasm: clinical and electrophysiologic studies. Muscle Nerve. 1989 Sep; 12(9):716-22. Geller BD, Hallett M, Ravits J. PMID: 2630907.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    83. Stimulus artifact compensation using biphasic stimulation. Muscle Nerve. 1988 Jun; 11(6):597-602. Nilsson J, Ravits J, Hallett M. PMID: 3386668.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    84. Myasthenia gravis. A well-understood neuromuscular disorder. Postgrad Med. 1988 Jan; 83(1):219-23. Ravits J. PMID: 3336605.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    85. A long-term follow-up study of patients with post-poliomyelitis neuromuscular symptoms. N Engl J Med. 1986 Apr 10; 314(15):959-63. Dalakas MC, Elder G, Hallett M, Ravits J, Baker M, Papadopoulos N, Albrecht P, Sever J. PMID: 3007983.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    86. Pathophysiology of hemifacial spasm. Neurology. 1986 Apr; 36(4):591-3. Ravits J, Hallett M. PMID: 3008029.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    87. Primary writing tremor and myoclonic writer's cramp. Neurology. 1985 Sep; 35(9):1387-91. Ravits J, Hallett M, Baker M, Wilkins D. PMID: 4022390.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    88. Transient monocular visual loss from narrow-angle glaucoma. Arch Neurol. 1984 Sep; 41(9):991-3. Ravits J, Seybold ME. PMID: 6477235.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    89. No morphometric abnormality recurrent laryngeal nerve in spastic dysphonia. Neurology. 1979 Oct; 29(10):1376-82. Ravits JM, Aronson AE, DeSanto LW, Dyck PJ. PMID: 573382.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    90. Prostatic adenocarcinoma of ductal origin. J Urol. 1979 Mar; 121(3):303-5. Greene LF, Farrow GM, Ravits JM, Tomera FM. PMID: 219263.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
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