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Eric Ahrens

Title(s)Professor, Radiology
SchoolHealth Sciences
Phone858-246-0279
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    Collapse Biography 
    Collapse Education and Training
    CALTECHSenior Research FellowDepartment of Biology
    University of California, Los AngelesPhD Physics
    University of California, Los Angeles BS Physics

    Collapse Research 
    Collapse Research Activities and Funding
    Product for sensitive imaging of cells in vivo
    NIH/NIBIB R41EB023761Jul 1, 2018 - Dec 31, 2018
    Role: Principal Investigator
    Compositions and methods for enhanced fluorine-19 magnetic resonance imaging cell tracking
    NIH/NIBIB R01EB024015Apr 15, 2017 - Feb 28, 2021
    Role: Principal Investigator
    Intracellular oxygen sensing using 19F MRI
    NIH/NIBIB R01EB017271Sep 1, 2013 - Aug 31, 2017
    Role: Principal Investigator
    Console Electronics Upgrade for 11.7T MRI System
    NIH S10OD010755Jun 15, 2013 - Jun 14, 2014
    Role: Principal Investigator
    Platform for myocardial infarct MRI and delivery of therapeutics
    NIH/NHLBI R41HL116014Aug 20, 2012 - Jul 31, 2013
    Role: Principal Investigator
    IN VIVO VISUALIZATION AND QUANTIFICATION OF EPIGENETIC ACTIVITIES USING MAGNETIC
    NIH/NIDA R56DA030330Sep 17, 2010 - May 31, 2013
    Role: Principal Investigator
    Clinical translation of 19F MRI to visualize cancer immunotherapeutic cells
    NIH/NCI R01CA134633May 10, 2009 - May 31, 2022
    Role: Principal Investigator
    NOVEL MARKERS FOR IMAGING GENE EXPRESSION IN VIVO USING MRI
    NIH/NIBIB R01EB005740Sep 7, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Pluripotent Stem Cells in Development and Disease
    NIH P01HD047675Aug 30, 2005 - May 31, 2012
    Role: Co-Investigator
    19F MRI probes and autoimmune disease
    NIH/NIBIB R01EB003453Feb 1, 2005 - Jan 31, 2010
    Role: Principal Investigator
    Adverse Pregnancy Outcomes: Genetic/Environmental Causes
    NIH P50ES012359Sep 30, 2002 - Jul 31, 2008
    Role: Co-Investigator
    MAGNETIC RESONANCE MICROSCOPY STUDY OF EAE
    NIH/NINDS F32NS010384Aug 1, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bravo-Hernandez M, Tadokoro T, Navarro MR, Platoshyn O, Kobayashi Y, Marsala S, Miyanohara A, Juhas S, Juhasova J, Skalnikova H, Tomori Z, Vanicky I, Studenovska H, Proks V, Chen P, Govea-Perez N, Ditsworth D, Ciacci JD, Gao S, Zhu W, Ahrens ET, Driscoll SP, Glenn TD, McAlonis-Downes M, Da Cruz S, Pfaff SL, Kaspar BK, Cleveland DW, Marsala M. Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. Nat Med. 2019 Dec 23. PMID: 31873312.
      View in: PubMed
    2. Hingorani DV, Chapelin F, Stares E, Adams SR, Okada H, Ahrens ET. Cell penetrating peptide functionalized perfluorocarbon nanoemulsions for targeted cell labeling and enhanced fluorine-19 MRI detection. Magn Reson Med. 2020 Mar; 83(3):974-987. PMID: 31631402.
      View in: PubMed
    3. Rho J, Stares E, Adams SR, Lister D, Leach B, Ahrens ET. Paramagnetic Fluorinated Nanoemulsions for in vivo F-19 MRI. Mol Imaging Biol. 2019 Sep 03. PMID: 31482414.
      View in: PubMed
    4. Jahromi AH, Wang C, Adams SR, Zhu W, Narsinh K, Xu H, Gray DL, Tsien RY, Ahrens ET. Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes. ACS Nano. 2019 01 22; 13(1):143-151. PMID: 30525446.
      View in: PubMed
    5. Chapelin F, Capitini CM, Ahrens ET. Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer. J Immunother Cancer. 2018 10 11; 6(1):105. PMID: 30305175.
      View in: PubMed
    6. Chapelin F, Gao S, Okada H, Weber TG, Messer K, Ahrens ET. Fluorine-19 nuclear magnetic resonance of chimeric antigen receptor T cell biodistribution in murine cancer model. Sci Rep. 2017 12 18; 7(1):17748. PMID: 29255242.
      View in: PubMed
    7. Khurana A, Chapelin F, Xu H, Acevedo JR, Molinolo A, Nguyen Q, Ahrens ET. Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging. Magn Reson Med. 2018 04; 79(4):1972-1980. PMID: 28748562.
      View in: PubMed
    8. Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M. Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. Mol Ther Methods Clin Dev. 2016; 3:16046. PMID: 27462649.
      View in: PubMed
    9. Kislukhin AA, Xu H, Adams SR, Narsinh KH, Tsien RY, Ahrens ET. Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging. Nat Mater. 2016 06; 15(6):662-8. PMID: 26974409.
      View in: PubMed
    10. Zhong J, Narsinh K, Morel PA, Xu H, Ahrens ET. In Vivo Quantification of Inflammation in Experimental Autoimmune Encephalomyelitis Rats Using Fluorine-19 Magnetic Resonance Imaging Reveals Immune Cell Recruitment outside the Nervous System. PLoS One. 2015; 10(10):e0140238. PMID: 26485716.
      View in: PubMed
    11. Ahrens ET, Helfer BM, O'Hanlon CF, Schirda C. Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine-19 MRI. Magn Reson Med. 2014 Dec; 72(6):1696-701. PMID: 25241945.
      View in: PubMed
    12. Kadayakkara DK, Damodaran K, Hitchens TK, Bulte JW, Ahrens ET. (19)F spin-lattice relaxation of perfluoropolyethers: Dependence on temperature and magnetic field strength (7.0-14.1T). J Magn Reson. 2014 May; 242:18-22. PMID: 24594752.
      View in: PubMed
    13. Hitchens TK, Liu L, Foley LM, Simplaceanu V, Ahrens ET, Ho C. Combining perfluorocarbon and superparamagnetic iron-oxide cell labeling for improved and expanded applications of cellular MRI. Magn Reson Med. 2015 Jan; 73(1):367-75. PMID: 24478194.
      View in: PubMed
    14. Patrick MJ, Janjic JM, Teng H, O'Hear MR, Brown CW, Stokum JA, Schmidt BF, Ahrens ET, Waggoner AS. Intracellular pH measurements using perfluorocarbon nanoemulsions. J Am Chem Soc. 2013 Dec 11; 135(49):18445-57. PMID: 24266634.
      View in: PubMed
    15. Ahrens ET, Bulte JW. Tracking immune cells in vivo using magnetic resonance imaging. Nat Rev Immunol. 2013 10; 13(10):755-63. PMID: 24013185.
      View in: PubMed
    16. Iordanova B, Hitchens TK, Robison CS, Ahrens ET. Engineered mitochondrial ferritin as a magnetic resonance imaging reporter in mouse olfactory epithelium. PLoS One. 2013; 8(8):e72720. PMID: 24023635.
      View in: PubMed
    17. Zwieniecki MA, Melcher PJ, Ahrens ET. Analysis of spatial and temporal dynamics of xylem refilling in Acer rubrum L. using magnetic resonance imaging. Front Plant Sci. 2013; 4:265. PMID: 23885258.
      View in: PubMed
    18. Zhong J, Sakaki M, Okada H, Ahrens ET. In vivo intracellular oxygen dynamics in murine brain glioma and immunotherapeutic response of cytotoxic T cells observed by fluorine-19 magnetic resonance imaging. PLoS One. 2013; 8(5):e59479. PMID: 23667419.
      View in: PubMed
    19. Ahrens ET, Zhong J. In vivo MRI cell tracking using perfluorocarbon probes and fluorine-19 detection. NMR Biomed. 2013 Jul; 26(7):860-71. PMID: 23606473.
      View in: PubMed
    20. Zhong J, Mills PH, Hitchens TK, Ahrens ET. Accelerated fluorine-19 MRI cell tracking using compressed sensing. Magn Reson Med. 2013 Jun; 69(6):1683-90. PMID: 22837054.
      View in: PubMed
    21. Balducci A, Helfer BM, Ahrens ET, O'Hanlon CF, Wesa AK. Visualizing arthritic inflammation and therapeutic response by fluorine-19 magnetic resonance imaging (19F MRI). J Inflamm (Lond). 2012 Jun 21; 9(1):24. PMID: 22721447.
      View in: PubMed
    22. Kadayakkara DK, Ranganathan S, Young WB, Ahrens ET. Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI. Lab Invest. 2012 Apr; 92(4):636-45. PMID: 22330343.
      View in: PubMed
    23. Bible E, Dell'Acqua F, Solanky B, Balducci A, Crapo PM, Badylak SF, Ahrens ET, Modo M. Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by (19)F- and diffusion-MRI. Biomaterials. 2012 Apr; 33(10):2858-71. PMID: 22244696.
      View in: PubMed
    24. Iordanova B, Ahrens ET. In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration. Neuroimage. 2012 Jan 16; 59(2):1004-12. PMID: 21939774.
      View in: PubMed
    25. Mills PH, Hitchens TK, Foley LM, Link T, Ye Q, Weiss CR, Thompson JD, Gilson WD, Arepally A, Melick JA, Kochanek PM, Ho C, Bulte JW, Ahrens ET. Automated detection and characterization of SPIO-labeled cells and capsules using magnetic field perturbations. Magn Reson Med. 2012 Jan; 67(1):278-89. PMID: 21656554.
      View in: PubMed
    26. Morel PA, Srinivas M, Turner MS, Fuschiotti P, Munshi R, Bahar I, Feili-Hariri M, Ahrens ET. Gene expression analysis of dendritic cells that prevent diabetes in NOD mice: analysis of chemokines and costimulatory molecules. J Leukoc Biol. 2011 Sep; 90(3):539-50. PMID: 21628331.
      View in: PubMed
    27. Ahrens ET, Young WB, Xu H, Pusateri LK. Rapid quantification of inflammation in tissue samples using perfluorocarbon emulsion and fluorine-19 nuclear magnetic resonance. Biotechniques. 2011 Apr; 50(4):229-34. PMID: 21548906.
      View in: PubMed
    28. Hitchens TK, Ye Q, Eytan DF, Janjic JM, Ahrens ET, Ho C. 19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells. Magn Reson Med. 2011 Apr; 65(4):1144-53. PMID: 21305593.
      View in: PubMed
    29. Bonetto F, Srinivas M, Heerschap A, Mailliard R, Ahrens ET, Figdor CG, de Vries IJ. A novel (19)F agent for detection and quantification of human dendritic cells using magnetic resonance imaging. Int J Cancer. 2011 Jul 15; 129(2):365-73. PMID: 20839261.
      View in: PubMed
    30. Kadayakkara DK, Janjic JM, Pusateri LK, Young WB, Ahrens ET. In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI. Magn Reson Med. 2010 Nov; 64(5):1252-9. PMID: 20860007.
      View in: PubMed
    31. Kadayakkara DK, Beatty PL, Turner MS, Janjic JM, Ahrens ET, Finn OJ. Inflammation driven by overexpression of the hypoglycosylated abnormal mucin 1 (MUC1) links inflammatory bowel disease and pancreatitis. Pancreas. 2010 May; 39(4):510-5. PMID: 20084048.
      View in: PubMed
    32. Srinivas M, Heerschap A, Ahrens ET, Figdor CG, de Vries IJ. (19)F MRI for quantitative in vivo cell tracking. Trends Biotechnol. 2010 Jul; 28(7):363-70. PMID: 20427096.
      View in: PubMed
    33. Helfer BM, Balducci A, Nelson AD, Janjic JM, Gil RR, Kalinski P, de Vries IJ, Ahrens ET, Mailliard RB. Functional assessment of human dendritic cells labeled for in vivo (19)F magnetic resonance imaging cell tracking. Cytotherapy. 2010 Apr; 12(2):238-50. PMID: 20053146.
      View in: PubMed
    34. Mills PH, Ahrens ET. Enhanced positive-contrast visualization of paramagnetic contrast agents using phase images. Magn Reson Med. 2009 Nov; 62(5):1349-55. PMID: 19780169.
      View in: PubMed
    35. Janjic JM, Ahrens ET. Fluorine-containing nanoemulsions for MRI cell tracking. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Sep-Oct; 1(5):492-501. PMID: 19920872.
      View in: PubMed
    36. Srinivas M, Turner MS, Janjic JM, Morel PA, Laidlaw DH, Ahrens ET. In vivo cytometry of antigen-specific t cells using 19F MRI. Magn Reson Med. 2009 Sep; 62(3):747-53. PMID: 19585593.
      View in: PubMed
    37. Janjic JM, Srinivas M, Kadayakkara DK, Ahrens ET. Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection. J Am Chem Soc. 2008 Mar 05; 130(9):2832-41. PMID: 18266363.
      View in: PubMed
    38. Srinivas M, Morel PA, Ernst LA, Laidlaw DH, Ahrens ET. Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model. Magn Reson Med. 2007 Oct; 58(4):725-34. PMID: 17899609.
      View in: PubMed
    39. Mills PH, Ahrens ET. Theoretical MRI contrast model for exogenous T2 agents. Magn Reson Med. 2007 Feb; 57(2):442-7. PMID: 17260382.
      View in: PubMed
    40. Ahrens ET, Srinivas M, Capuano S, Simhan HN, Schatten GP. Magnetic resonance imaging of embryonic and fetal development in model systems. Methods Mol Med. 2006; 124:87-101. PMID: 16506418.
      View in: PubMed
    41. Ahrens ET, Flores R, Xu H, Morel PA. In vivo imaging platform for tracking immunotherapeutic cells. Nat Biotechnol. 2005 Aug; 23(8):983-7. PMID: 16041364.
      View in: PubMed
    42. Genove G, DeMarco U, Xu H, Goins WF, Ahrens ET. A new transgene reporter for in vivo magnetic resonance imaging. Nat Med. 2005 Apr; 11(4):450-4. PMID: 15778721.
      View in: PubMed
    43. Ahrens ET. Emerging non-invasive imaging techniques using magnetic resonance imaging. Curr Top Dev Biol. 2005; 70:xi. PMID: 16338334.
      View in: PubMed
    44. Ahrens ET, Morel PA. In vivo imaging of autoimmune disease in model systems. Curr Top Dev Biol. 2005; 70:215-38. PMID: 16338343.
      View in: PubMed
    45. Ahrens ET, Feili-Hariri M, Xu H, Genove G, Morel PA. Receptor-mediated endocytosis of iron-oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging. Magn Reson Med. 2003 Jun; 49(6):1006-13. PMID: 12768577.
      View in: PubMed
    46. Holbrook NM, Ahrens ET, Burns MJ, Zwieniecki MA. In vivo observation of cavitation and embolism repair using magnetic resonance imaging. Plant Physiol. 2001 May; 126(1):27-31. PMID: 11351066.
      View in: PubMed
    47. Louie AY, Hüber MM, Ahrens ET, Rothbächer U, Moats R, Jacobs RE, Fraser SE, Meade TJ. In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol. 2000 Mar; 18(3):321-5. PMID: 10700150.
      View in: PubMed
    48. Ahrens ET, Laidlaw DH, Readhead C, Brosnan CF, Fraser SE, Jacobs RE. MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis. Magn Reson Med. 1998 Jul; 40(1):119-32. PMID: 9660562.
      View in: PubMed
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