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Amr Hamdoun

Title(s)Professor, Scripps Institution of Oceanography Department
SchoolMarine Sciences
Phone858-822-5839
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    Collapse Research 
    Collapse Research Activities and Funding
    Structure and function of ABC transporters to understand persistence of global ma
    NIH/NIEHS R01ES021985Sep 24, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Control of Multidrug Transport Activity in Embryos
    NIH R00HD058070Jan 1, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Control of efflux transporter activity by cell surface reorganization in embryos.
    NIH K99HD058070May 7, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Initiation of Multidrug Transport at Fertilization.
    NIH F32HD047136Jan 1, 2005 - Dec 31, 2007
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li A, Espinoza J, Hamdoun A. Inhibitory effects of neurotoxin ß-N-methylamino-L-alanine on fertilization and early development of the sea urchin Lytechinus pictus. Aquat Toxicol. 2020 Jan 30; 221:105425. PMID: 32058875.
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    2. Gordon WE, Espinoza JA, Leerberg DM, Yelon D, Hamdoun A. Xenobiotic transporter activity in zebrafish embryo ionocytes. Aquat Toxicol. 2019 Jul; 212:88-97. PMID: 31077970.
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    3. Schrankel CS, Gökirmak T, Lee CW, Chang G, Hamdoun A. Generation, expression and utilization of single-domain antibodies for in vivo protein localization and manipulation in sea urchin embryos. Methods Cell Biol. 2019; 151:353-376. PMID: 30948018.
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    4. Shipp LE, Hill RZ, Hamdoun A. A teaching laboratory on the activation of xenobiotic transporters at fertilization of sea urchins. Methods Cell Biol. 2019; 150:429-447. PMID: 30777187.
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    5. Nesbit KT, Fleming T, Batzel G, Pouv A, Rosenblatt HD, Pace DA, Hamdoun A, Lyons DC. The painted sea urchin, Lytechinus pictus, as a genetically-enabled developmental model. Methods Cell Biol. 2019; 150:105-123. PMID: 30777173.
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    6. Campanale JP, Hamdoun A, Wessel GM, Su YH, Oulhen N. Methods to label, isolate, and image sea urchin small micromeres, the primordial germ cells (PGCs). Methods Cell Biol. 2019; 150:269-292. PMID: 30777180.
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    7. Foltz KR, Hamdoun A. Preface. Methods Cell Biol. 2019; 150:xix-xx. PMID: 30777193.
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    8. Hamdoun A, Foltz KR. Preface. Methods Cell Biol. 2019; 151:xxi-xxii. PMID: 30948034.
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    9. Barron ME, Thies AB, Espinoza JA, Barott KL, Hamdoun A, Tresguerres M. A vesicular Na+/Ca2+ exchanger in coral calcifying cells. PLoS One. 2018; 13(10):e0205367. PMID: 30379874.
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    10. Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway. J Nat Prod. 2018 03 23; 81(3):506-514. PMID: 29215273.
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    11. Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. Geographic Differences in Persistent Organic Pollutant Levels of Yellowfin Tuna. Environ Health Perspect. 2017 06 26; 125(6):067014. PMID: 28686554.
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    12. Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. Mercury levels of yellowfin tuna (Thunnus albacares) are associated with capture location. Environ Pollut. 2017 Oct; 229:87-93. PMID: 28577385.
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    13. Ramakrishnan L, Uhlinger K, Dale L, Hamdoun A, Patel S. ADP-ribosyl cyclases regulate early development of the sea urchin. Messenger (Los Angel). 2016 Jun 01; 5(1-2):100-106. PMID: 28529830.
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    14. Nicklisch SC, Rees SD, McGrath AP, Gökirmak T, Bonito LT, Vermeer LM, Cregger C, Loewen G, Sandin S, Chang G, Hamdoun A. Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Sci Adv. 2016 Apr; 2(4):e1600001. PMID: 27152359.
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    15. Gökirmak T, Campanale JP, Reitzel AM, Shipp LE, Moy GW, Hamdoun A. Functional diversification of sea urchin ABCC1 (MRP1) by alternative splicing. Am J Physiol Cell Physiol. 2016 06 01; 310(11):C911-20. PMID: 27053522.
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    16. Bonito LT, Hamdoun A, Sandin SA. Evaluation of the global impacts of mitigation on persistent, bioaccumulative and toxic pollutants in marine fish. PeerJ. 2016; 4:e1573. PMID: 26839747.
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    17. Shipp LE, Hill RZ, Moy GW, Gökirmak T, Hamdoun A. ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos. Development. 2015 Oct 15; 142(20):3537-48. PMID: 26395488.
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    18. Gökirmak T, Shipp LE, Campanale JP, Nicklisch SC, Hamdoun A. Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos. Mol Reprod Dev. 2014 Sep; 81(9):778-93. PMID: 25156004.
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    19. Swartz SZ, Reich AM, Oulhen N, Raz T, Milos PM, Campanale JP, Hamdoun A, Wessel GM. Deadenylase depletion protects inherited mRNAs in primordial germ cells. Development. 2014 Aug; 141(16):3134-42. PMID: 25100654.
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    20. Campanale JP, Gökirmak T, Espinoza JA, Oulhen N, Wessel GM, Hamdoun A. Migration of sea urchin primordial germ cells. Dev Dyn. 2014 Jul; 243(7):917-27. PMID: 24677545.
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    21. Cole BJ, Hamdoun A, Epel D. Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos. J Exp Biol. 2013 Oct 15; 216(Pt 20):3896-905. PMID: 23913944.
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    22. Gökirmak T, Campanale JP, Shipp LE, Moy GW, Tao H, Hamdoun A. Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters. J Biol Chem. 2012 Dec 21; 287(52):43876-83. PMID: 23124201.
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    23. Whalen K, Reitzel AM, Hamdoun A. Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli. Mol Biol Cell. 2012 Sep; 23(18):3663-72. PMID: 22855533.
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    24. Shipp LE, Hamdoun A. ATP-binding cassette (ABC) transporter expression and localization in sea urchin development. Dev Dyn. 2012 Jun; 241(6):1111-24. PMID: 22473856.
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    25. Campanale JP, Hamdoun A. Programmed reduction of ABC transporter activity in sea urchin germline progenitors. Development. 2012 Feb; 139(4):783-92. PMID: 22274698.
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    26. Patel S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E. The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium. 2011 Aug; 50(2):157-67. PMID: 21529939.
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    27. Bosnjak I, Uhlinger KR, Heim W, Smital T, Franekic-Colic J, Coale K, Epel D, Hamdoun A. Multidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos. Environ Sci Technol. 2009 Nov 01; 43(21):8374-80. PMID: 19924972.
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    28. Epel D, Luckenbach T, Stevenson CN, Macmanus-Spencer LA, Hamdoun A, Smital T. Efflux transporters: newly appreciated roles in protection against pollutants. Environ Sci Technol. 2008 Jun 01; 42(11):3914-20. PMID: 18589945.
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    29. Hamdoun A, Epel D. Embryo stability and vulnerability in an always changing world. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1745-50. PMID: 17264211.
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    30. Roepke TA, Hamdoun AM, Cherr GN. Increase in multidrug transport activity is associated with oocyte maturation in sea stars. Dev Growth Differ. 2006 Dec; 48(9):559-73. PMID: 17118011.
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    31. Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R. The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006 Nov 10; 314(5801):941-52. PMID: 17095691.
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    32. Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol. 2006 Dec 01; 300(1):366-84. PMID: 17097629.
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    33. Epel D, Cole B, Hamdoun A, Thurber RV. The sea urchin embryo as a model for studying efflux transporters: roles and energy cost. Mar Environ Res. 2006 Jul; 62 Suppl:S1-4. PMID: 16740304.
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    34. Hamdoun AM, Cherr GN, Roepke TA, Epel D. Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus). Dev Biol. 2004 Dec 15; 276(2):452-62. PMID: 15581878.
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    35. Smital T, Luckenbach T, Sauerborn R, Hamdoun AM, Vega RL, Epel D. Emerging contaminants--pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms. Mutat Res. 2004 Aug 18; 552(1-2):101-17. PMID: 15288544.
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    36. Hamdoun AM, Cheney DP, Cherr GN. Phenotypic plasticity of HSP70 and HSP70 gene expression in the Pacific oyster (Crassostrea gigas): implications for thermal limits and induction of thermal tolerance. Biol Bull. 2003 Oct; 205(2):160-9. PMID: 14583513.
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    37. Hamdoun AM, Griffin FJ, Cherr GN. Tolerance to biodegraded crude oil in marine invertebrate embryos and larvae is associated with expression of a multixenobiotic resistance transporter. Aquat Toxicol. 2002 Nov 13; 61(1-2):127-40. PMID: 12297376.
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