Amro Hamdoun

Title(s)Professor, Scripps Institution of Oceanography Department
SchoolVc-marine Sciences
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanisms of Marine Organohalogen Bioaccumulation and Neurotoxicity
    NIH R01ES030318Sep 15, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Identity, mechanisms and early life impacts of transporter interfering compounds
    NIH R01ES027921Jun 1, 2018 - May 31, 2023
    Role: Principal Investigator
    Structure and function of ABC transporters to understand persistence of global ma
    NIH R01ES021985Sep 24, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Control of Multidrug Transport Activity in Embryos
    NIH R00HD058070Jan 1, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Control of efflux transporter activity by cell surface reorganization in embryos.
    NIH K99HD058070May 7, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Initiation of Multidrug Transport at Fertilization.
    NIH F32HD047136Jan 1, 2005 - Dec 31, 2007
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Generation of a homozygous mutant drug transporter (ABCB1) knockout line in the sea urchin Lytechinus pictus. Development. 2022 06 01; 149(11). Vyas H, Schrankel CS, Espinoza JA, Mitchell KL, Nesbit KT, Jackson E, Chang N, Lee Y, Warner J, Reitzel A, Lyons DC, Hamdoun A. PMID: 35666622; PMCID: PMC9245184.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. New techniques for creating parthenogenetic larvae of the sea urchin Lytechinus pictus for gene expression studies. Dev Dyn. 2021 12; 250(12):1828-1833. Vacquier VD, Hamdoun A. PMID: 34042247; PMCID: PMC8626522.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares). Comp Biochem Physiol C Toxicol Pharmacol. 2021 Oct; 248:109101. Nicklisch SCT, Pouv AK, Rees SD, McGrath AP, Chang G, Hamdoun A. PMID: 34116183.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    4. Chromosomal-Level Genome Assembly of the Painted Sea Urchin Lytechinus pictus: A Genetically Enabled Model System for Cell Biology and Embryonic Development. Genome Biol Evol. 2021 04 05; 13(4). Warner JF, Lord JW, Schreiter SA, Nesbit KT, Hamdoun A, Lyons DC. PMID: 33769486; PMCID: PMC8085125.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. CRISPR/Cas9 mutagenesis reveals a role for ABCB1 in gut immune responses to Vibrio diazotrophicus in sea urchin larvae. J Exp Biol. 2021 04 01; 224(7). Fleming TJ, Schrankel CS, Vyas H, Rosenblatt HD, Hamdoun A. PMID: 33653719; PMCID: PMC8077557.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. The incredible diversity of structures and functions of ABC transporters. FEBS Lett. 2021 03; 595(6):671-674. Hamdoun A, Hellmich UA, Szakacs G, Kuchler K. PMID: 33754351.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. Early patterning of ABCB, ABCC, and ABCG transporters establishes unique territories of small molecule transport in embryonic mesoderm and endoderm. Dev Biol. 2021 04; 472:115-124. Schrankel CS, Hamdoun A. PMID: 33460641; PMCID: PMC8171262.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Disruption of small molecule transporter systems by Transporter-Interfering Chemicals (TICs). FEBS Lett. 2020 12; 594(23):4158-4185. Nicklisch SCT, Hamdoun A. PMID: 33222203; PMCID: PMC8112642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Human Health and Ocean Pollution. Ann Glob Health. 2020 12 03; 86(1):151. Landrigan PJ, Stegeman JJ, Fleming LE, Allemand D, Anderson DM, Backer LC, Brucker-Davis F, Chevalier N, Corra L, Czerucka D, Bottein MD, Demeneix B, Depledge M, Deheyn DD, Dorman CJ, Fénichel P, Fisher S, Gaill F, Galgani F, Gaze WH, Giuliano L, Grandjean P, Hahn ME, Hamdoun A, Hess P, Judson B, Laborde A, McGlade J, Mu J, Mustapha A, Neira M, Noble RT, Pedrotti ML, Reddy C, Rocklöv J, Scharler UM, Shanmugam H, Taghian G, van de Water JAJM, Vezzulli L, Weihe P, Zeka A, Raps H, Rampal P. PMID: 33354517; PMCID: PMC7731724.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsPHPublic Health
    10. Embryo, larval, and juvenile staging of Lytechinus pictus from fertilization through sexual maturation. Dev Dyn. 2020 11; 249(11):1334-1346. Nesbit KT, Hamdoun A. PMID: 32644271; PMCID: PMC8153651.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    11. Inhibitory effects of neurotoxin β-N-methylamino-L-alanine on fertilization and early development of the sea urchin Lytechinus pictus. Aquat Toxicol. 2020 Apr; 221:105425. Li A, Espinoza J, Hamdoun A. PMID: 32058875.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Xenobiotic transporter activity in zebrafish embryo ionocytes. Aquat Toxicol. 2019 Jul; 212:88-97. Gordon WE, Espinoza JA, Leerberg DM, Yelon D, Hamdoun A. PMID: 31077970; PMCID: PMC6561644.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Generation, expression and utilization of single-domain antibodies for in vivo protein localization and manipulation in sea urchin embryos. Methods Cell Biol. 2019; 151:353-376. Schrankel CS, Gökirmak T, Lee CW, Chang G, Hamdoun A. PMID: 30948018; PMCID: PMC6489465.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. A teaching laboratory on the activation of xenobiotic transporters at fertilization of sea urchins. Methods Cell Biol. 2019; 150:429-447. Shipp LE, Hill RZ, Hamdoun A. PMID: 30777187; PMCID: PMC6487851.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. The painted sea urchin, Lytechinus pictus, as a genetically-enabled developmental model. Methods Cell Biol. 2019; 150:105-123. Nesbit KT, Fleming T, Batzel G, Pouv A, Rosenblatt HD, Pace DA, Hamdoun A, Lyons DC. PMID: 30777173; PMCID: PMC6487866.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Methods to label, isolate, and image sea urchin small micromeres, the primordial germ cells (PGCs). Methods Cell Biol. 2019; 150:269-292. Campanale JP, Hamdoun A, Wessel GM, Su YH, Oulhen N. PMID: 30777180; PMCID: PMC6487853.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Preface. Methods Cell Biol. 2019; 150:xix-xx. Foltz KR, Hamdoun A. PMID: 30777193.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Preface. Methods Cell Biol. 2019; 151:xxi-xxii. Hamdoun A, Foltz KR. PMID: 30948034; PMCID: PMC6534141.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. A vesicular Na+/Ca2+ exchanger in coral calcifying cells. PLoS One. 2018; 13(10):e0205367. Barron ME, Thies AB, Espinoza JA, Barott KL, Hamdoun A, Tresguerres M. PMID: 30379874; PMCID: PMC6209159.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    20. Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway. J Nat Prod. 2018 03 23; 81(3):506-514. Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. PMID: 29215273; PMCID: PMC6553616.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Geographic Differences in Persistent Organic Pollutant Levels of Yellowfin Tuna. Environ Health Perspect. 2017 06 26; 125(6):067014. Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. PMID: 28686554; PMCID: PMC5714290.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsPHPublic Health
    22. Mercury levels of yellowfin tuna (Thunnus albacares) are associated with capture location. Environ Pollut. 2017 Oct; 229:87-93. Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. PMID: 28577385; PMCID: PMC6544047.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsPHPublic Health
    23. ADP-ribosyl cyclases regulate early development of the sea urchin. Messenger (Los Angel). 2016 Jun 01; 5(1-2):100-106. Ramakrishnan L, Uhlinger K, Dale L, Hamdoun A, Patel S. PMID: 28529830; PMCID: PMC5435102.
      View in: PubMed   Mentions: 2  
    24. Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Sci Adv. 2016 Apr; 2(4):e1600001. Nicklisch SC, Rees SD, McGrath AP, Gökirmak T, Bonito LT, Vermeer LM, Cregger C, Loewen G, Sandin S, Chang G, Hamdoun A. PMID: 27152359; PMCID: PMC4846432.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    25. Functional diversification of sea urchin ABCC1 (MRP1) by alternative splicing. Am J Physiol Cell Physiol. 2016 06 01; 310(11):C911-20. Gökirmak T, Campanale JP, Reitzel AM, Shipp LE, Moy GW, Hamdoun A. PMID: 27053522; PMCID: PMC4935205.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    26. Evaluation of the global impacts of mitigation on persistent, bioaccumulative and toxic pollutants in marine fish. PeerJ. 2016; 4:e1573. Bonito LT, Hamdoun A, Sandin SA. PMID: 26839747; PMCID: PMC4734435.
      View in: PubMed   Mentions: 7     Fields:    
    27. ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos. Development. 2015 Oct 15; 142(20):3537-48. Shipp LE, Hill RZ, Moy GW, Gökirmak T, Hamdoun A. PMID: 26395488; PMCID: PMC4631766.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos. Mol Reprod Dev. 2014 Sep; 81(9):778-93. Gökirmak T, Shipp LE, Campanale JP, Nicklisch SC, Hamdoun A. PMID: 25156004; PMCID: PMC4162837.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    29. Deadenylase depletion protects inherited mRNAs in primordial germ cells. Development. 2014 Aug; 141(16):3134-42. Swartz SZ, Reich AM, Oulhen N, Raz T, Milos PM, Campanale JP, Hamdoun A, Wessel GM. PMID: 25100654; PMCID: PMC4197533.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. Migration of sea urchin primordial germ cells. Dev Dyn. 2014 Jul; 243(7):917-27. Campanale JP, Gökirmak T, Espinoza JA, Oulhen N, Wessel GM, Hamdoun A. PMID: 24677545; PMCID: PMC4164171.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    31. Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos. J Exp Biol. 2013 Oct 15; 216(Pt 20):3896-905. Cole BJ, Hamdoun A, Epel D. PMID: 23913944; PMCID: PMC3784358.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters. J Biol Chem. 2012 Dec 21; 287(52):43876-83. Gökirmak T, Campanale JP, Shipp LE, Moy GW, Tao H, Hamdoun A. PMID: 23124201; PMCID: PMC3527970.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    33. Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli. Mol Biol Cell. 2012 Sep; 23(18):3663-72. Whalen K, Reitzel AM, Hamdoun A. PMID: 22855533; PMCID: PMC3442413.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    34. ATP-binding cassette (ABC) transporter expression and localization in sea urchin development. Dev Dyn. 2012 Jun; 241(6):1111-24. Shipp LE, Hamdoun A. PMID: 22473856; PMCID: PMC3354041.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    35. Programmed reduction of ABC transporter activity in sea urchin germline progenitors. Development. 2012 Feb; 139(4):783-92. Campanale JP, Hamdoun A. PMID: 22274698; PMCID: PMC3265063.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium. 2011 Aug; 50(2):157-67. Patel S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E. PMID: 21529939; PMCID: PMC3160778.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    37. Multidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos. Environ Sci Technol. 2009 Nov 01; 43(21):8374-80. Bosnjak I, Uhlinger KR, Heim W, Smital T, Franekic-Colic J, Coale K, Epel D, Hamdoun A. PMID: 19924972; PMCID: PMC3166226.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    38. Efflux transporters: newly appreciated roles in protection against pollutants. Environ Sci Technol. 2008 Jun 01; 42(11):3914-20. Epel D, Luckenbach T, Stevenson CN, Macmanus-Spencer LA, Hamdoun A, Smital T. PMID: 18589945; PMCID: PMC3160781.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    39. Embryo stability and vulnerability in an always changing world. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1745-50. Hamdoun A, Epel D. PMID: 17264211; PMCID: PMC1794293.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsPHPublic Health
    40. Increase in multidrug transport activity is associated with oocyte maturation in sea stars. Dev Growth Differ. 2006 Dec; 48(9):559-73. Roepke TA, Hamdoun AM, Cherr GN. PMID: 17118011; PMCID: PMC3159419.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    41. The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006 Nov 10; 314(5801):941-52. Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R. PMID: 17095691; PMCID: PMC3159423.
      View in: PubMed   Mentions: 417     Fields:    Translation:AnimalsCells
    42. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol. 2006 Dec 01; 300(1):366-84. Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. PMID: 17097629; PMCID: PMC3166225.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    43. The sea urchin embryo as a model for studying efflux transporters: roles and energy cost. Mar Environ Res. 2006 Jul; 62 Suppl:S1-4. Epel D, Cole B, Hamdoun A, Thurber RV. PMID: 16740304; PMCID: PMC3160780.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    44. Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus). Dev Biol. 2004 Dec 15; 276(2):452-62. Hamdoun AM, Cherr GN, Roepke TA, Epel D. PMID: 15581878.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    45. Emerging contaminants--pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms. Mutat Res. 2004 Aug 18; 552(1-2):101-17. Smital T, Luckenbach T, Sauerborn R, Hamdoun AM, Vega RL, Epel D. PMID: 15288544.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    46. Phenotypic plasticity of HSP70 and HSP70 gene expression in the Pacific oyster (Crassostrea gigas): implications for thermal limits and induction of thermal tolerance. Biol Bull. 2003 Oct; 205(2):160-9. Hamdoun AM, Cheney DP, Cherr GN. PMID: 14583513.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
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