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Amr Hamdoun

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentScripps Institution of Oceanography Department
Address9500 Gilman Drive #0202
La Jolla CA 92093
Phone858-822-5839
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    Collapse Research 
    Collapse Research Activities and Funding
    Structure and function of ABC transporters to understand persistence of global ma
    NIH/NIEHS R01ES021985Sep 24, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Control of Multidrug Transport Activity in Embryos
    NIH R00HD058070Jan 1, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Control of efflux transporter activity by cell surface reorganization in embryos.
    NIH K99HD058070May 7, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Initiation of Multidrug Transport at Fertilization.
    NIH F32HD047136Jan 1, 2005 - Dec 31, 2007
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway. J Nat Prod. 2018 Mar 23; 81(3):506-514. PMID: 29215273.
      View in: PubMed
    2. Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. Geographic Differences in Persistent Organic Pollutant Levels of Yellowfin Tuna. Environ Health Perspect. 2017 06 26; 125(6):067014. PMID: 28686554.
      View in: PubMed
    3. Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. Mercury levels of yellowfin tuna (Thunnus albacares) are associated with capture location. Environ Pollut. 2017 Oct; 229:87-93. PMID: 28577385.
      View in: PubMed
    4. Ramakrishnan L, Uhlinger K, Dale L, Hamdoun A, Patel S. ADP-ribosyl cyclases regulate early development of the sea urchin. Messenger (Los Angel). 2016 Jun 01; 5(1-2):100-106. PMID: 28529830.
      View in: PubMed
    5. Nicklisch SC, Rees SD, McGrath AP, Gökirmak T, Bonito LT, Vermeer LM, Cregger C, Loewen G, Sandin S, Chang G, Hamdoun A. Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Sci Adv. 2016 Apr; 2(4):e1600001. PMID: 27152359; PMCID: PMC4846432.
    6. Gökirmak T, Campanale JP, Reitzel AM, Shipp LE, Moy GW, Hamdoun A. Functional diversification of sea urchin ABCC1 (MRP1) by alternative splicing. Am J Physiol Cell Physiol. 2016 Jun 01; 310(11):C911-20. PMID: 27053522; PMCID: PMC4935205 [Available on 06/01/17].
    7. Bonito LT, Hamdoun A, Sandin SA. Evaluation of the global impacts of mitigation on persistent, bioaccumulative and toxic pollutants in marine fish. PeerJ. 2016; 4:e1573. PMID: 26839747; PMCID: PMC4734435.
    8. Shipp LE, Hill RZ, Moy GW, Gökirmak T, Hamdoun A. ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos. Development. 2015 Oct 15; 142(20):3537-48. PMID: 26395488; PMCID: PMC4631766 [Available on 10/15/16].
    9. Gökirmak T, Shipp LE, Campanale JP, Nicklisch SC, Hamdoun A. Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos. Mol Reprod Dev. 2014 Sep; 81(9):778-93. PMID: 25156004; PMCID: PMC4162837.
    10. Swartz SZ, Reich AM, Oulhen N, Raz T, Milos PM, Campanale JP, Hamdoun A, Wessel GM. Deadenylase depletion protects inherited mRNAs in primordial germ cells. Development. 2014 Aug; 141(16):3134-42. PMID: 25100654; PMCID: PMC4197533.
    11. Campanale JP, Gökirmak T, Espinoza JA, Oulhen N, Wessel GM, Hamdoun A. Migration of sea urchin primordial germ cells. Dev Dyn. 2014 Jul; 243(7):917-27. PMID: 24677545; PMCID: PMC4164171.
    12. Cole BJ, Hamdoun A, Epel D. Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos. J Exp Biol. 2013 Oct 15; 216(Pt 20):3896-905. PMID: 23913944; PMCID: PMC3784358.
    13. Gökirmak T, Campanale JP, Shipp LE, Moy GW, Tao H, Hamdoun A. Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters. J Biol Chem. 2012 Dec 21; 287(52):43876-83. PMID: 23124201; PMCID: PMC3527970.
    14. Whalen K, Reitzel AM, Hamdoun A. Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli. Mol Biol Cell. 2012 Sep; 23(18):3663-72. PMID: 22855533; PMCID: PMC3442413.
    15. Shipp LE, Hamdoun A. ATP-binding cassette (ABC) transporter expression and localization in sea urchin development. Dev Dyn. 2012 Jun; 241(6):1111-24. PMID: 22473856; PMCID: PMC3354041.
    16. Campanale JP, Hamdoun A. Programmed reduction of ABC transporter activity in sea urchin germline progenitors. Development. 2012 Feb; 139(4):783-92. PMID: 22274698; PMCID: PMC3265063.
    17. Patel S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E. The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium. 2011 Aug; 50(2):157-67. PMID: 21529939; PMCID: PMC3160778.
    18. Bosnjak I, Uhlinger KR, Heim W, Smital T, Franekic-Colic J, Coale K, Epel D, Hamdoun A. Multidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos. Environ Sci Technol. 2009 Nov 01; 43(21):8374-80. PMID: 19924972; PMCID: PMC3166226.
    19. Epel D, Luckenbach T, Stevenson CN, Macmanus-Spencer LA, Hamdoun A, Smital T. Efflux transporters: newly appreciated roles in protection against pollutants. Environ Sci Technol. 2008 Jun 01; 42(11):3914-20. PMID: 18589945; PMCID: PMC3160781.
    20. Hamdoun A, Epel D. Embryo stability and vulnerability in an always changing world. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1745-50. PMID: 17264211; PMCID: PMC1794293.
    21. Roepke TA, Hamdoun A, Cherr GN. Increase in multidrug transport activity is associated with oocyte maturation in sea stars. Dev Growth Differ. 2006 Dec; 48(9):559-73. PMID: 17118011; PMCID: PMC3159419.
    22. The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006 Nov 10; 314(5801):941-52. PMID: 17095691; PMCID: PMC3159423.
    23. Epel D, Cole B, Hamdoun A, Thurber RV. The sea urchin embryo as a model for studying efflux transporters: roles and energy cost. Mar Environ Res. 2006 Jul; 62 Suppl:S1-4. PMID: 16740304; PMCID: PMC3160780.
    24. Hamdoun A, Cherr GN, Roepke TA, Epel D. Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus). Dev Biol. 2004 Dec 15; 276(2):452-62. PMID: 15581878.
      View in: PubMed
    25. Smital T, Luckenbach T, Sauerborn R, Hamdoun A, Vega RL, Epel D. Emerging contaminants--pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms. Mutat Res. 2004 Aug 18; 552(1-2):101-17. PMID: 15288544.
      View in: PubMed
    26. Hamdoun A, Cheney DP, Cherr GN. Phenotypic plasticity of HSP70 and HSP70 gene expression in the Pacific oyster (Crassostrea gigas): implications for thermal limits and induction of thermal tolerance. Biol Bull. 2003 Oct; 205(2):160-9. PMID: 14583513.
      View in: PubMed
    27. Hamdoun A, Griffin FJ, Cherr GN. Tolerance to biodegraded crude oil in marine invertebrate embryos and larvae is associated with expression of a multixenobiotic resistance transporter. Aquat Toxicol. 2002 Nov 13; 61(1-2):127-40. PMID: 12297376.
      View in: PubMed