Shujuan Chen
|
Title(s) | Assistant Adjunct Professor, Pharmacology |
---|
School | Health Sciences |
---|
Address | 9500 Gilman Drive #0722 La Jolla CA 92093
|
---|
Phone | 858-822-1351 |
---|
vCard | Download vCard |
---|
|
|
Biography Huazhong University of Science and Technology | Ph.D | | | Huazhong University of Science and Technology | Pharm.D | | |
Overview
Implementing mouse genetics to examine the mechanisms leading to regulation and expression of the drug processing genes has been the central focus of my research. Derived from my long-term interest in the role of xenobiotic nuclear receptors (NRs) with advancement in deep sequencing technology, my most recent research interest has been further expanded to nuclear receptor corepressor (NCoR1) and its physiological and pharmacological functions during development. I have also been engaged in several other research areas, including developmental brain toxicity, cancer development, and stem cell research.
Research ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
Click a Field or Translation tag to filter the publications.
-
NCoR1 Protects Mice From Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult. Cell Mol Gastroenterol Hepatol. 2020; 10(1):133-147.
Mennillo E, Yang X, Paszek M, Auwerx J, Benner C, Chen S. PMID: 32044398.
View in: PubMed Mentions: 1 Fields:
-
Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice. Drug Metab Dispos. 2018 11; 46(11):1745-1755.
Chen S, Tukey RH. PMID: 30093417.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimals
-
Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies. Drug Metab Dispos. 2017 07; 45(7):748-754.
Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. PMID: 28468837.
View in: PubMed Mentions: 6 Fields: Translation: Animals
-
Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep. 2017 04 19; 7:46489.
Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey RH. PMID: 28422158.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimals
-
Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia. Mol Pharmacol. 2017 May; 91(5):545-553.
Yueh MF, Chen S, Nguyen N, Tukey RH. PMID: 28283555.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimals
-
Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440.
Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
-
Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARa. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E244-E252.
Hinds TD, Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE. PMID: 28096081.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
-
Cadmium and arsenic override NF-?B developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46.
Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH. PMID: 27060662.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
-
Stage-specific regulation of the WNT/ß-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol. 2016 06; 64(6):1315-26.
Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC. PMID: 26921690.
View in: PubMed Mentions: 19 Fields: Translation: HumansCells
-
Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia. Mol Pharmacol. 2016 Jan; 89(1):84-93.
Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. PMID: 26480925.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
-
Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):63-76.e5.
Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH. PMID: 26807433.
View in: PubMed Mentions: 2 Fields:
-
Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol. 2015 Nov 15; 289(1):124-32.
Fujiwara R, Maruo Y, Chen S, Tukey RH. PMID: 26342858.
View in: PubMed Mentions: 12 Fields: Translation: Humans
-
The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5.
Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. PMID: 25404284.
View in: PubMed Mentions: 47 Fields: Translation: HumansAnimalsCells
-
Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 2014 Feb 21; 289(8):4699-709.
Yueh MF, Chen S, Nguyen N, Tukey RH. PMID: 24403077.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
-
Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8.
Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. PMID: 24191041.
View in: PubMed Mentions: 20 Fields: Translation: Animals
-
Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 2012 Aug; 56(2):658-67.
Chen S, Yueh MF, Evans RM, Tukey RH. PMID: 22371261.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimalsCells
-
Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2.
Fujiwara R, Chen S, Karin M, Tukey RH. PMID: 21983082.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
-
Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5024-9.
Fujiwara R, Nguyen N, Chen S, Tukey RH. PMID: 20194756.
View in: PubMed Mentions: 40 Fields: Translation: HumansAnimals
-
A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos. 2010 May; 38(5):879-86.
Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC. PMID: 20124398.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
-
Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21; 283(12):7901-11.
Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH. PMID: 18180294.
View in: PubMed Mentions: 34 Fields: Translation: HumansAnimals
-
Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar; 35(3):419-27.
Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. PMID: 17151188.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
-
Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci. 2007 Jan; 95(1):98-107.
Operaña TN, Nguyen N, Chen S, Beaton D, Tukey RH. PMID: 17065433.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCellsPHPublic Health
-
Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11; 280(45):37547-57.
Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. PMID: 16155002.
View in: PubMed Mentions: 34 Fields: Translation: HumansAnimalsCells
-
Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol. 2005 Apr; 67(4):1247-56.
Bonzo JA, Chen S, Galijatovic A, Tukey RH. PMID: 15630080.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
-
ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem. 2005 Feb 11; 280(6):4350-9.
Chen S, Operaña T, Bonzo J, Nguyen N, Tukey RH. PMID: 15572374.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
-
The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76.
Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. PMID: 15037607.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
-
The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33.
Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. PMID: 12637498.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
-
Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 2003 Apr 25; 278(17):15001-6.
Yueh MF, Huang YH, Hiller A, Chen S, Nguyen N, Tukey RH. PMID: 12566446.
View in: PubMed Mentions: 38 Fields: Translation: HumansCells
This graph shows the total number of publications by year. To see the data as text, click here.
This graph shows the total number of publications by year. To return to the graph, click here.
Year | Publications |
---|
2003 | 2 | 2004 | 2 | 2005 | 2 | 2006 | 2 | 2008 | 1 | 2010 | 2 | 2011 | 1 | 2012 | 1 | 2013 | 1 | 2014 | 2 | 2015 | 3 | 2016 | 2 | 2017 | 5 | 2018 | 1 | 2020 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
newest
oldest
line numbers
double spacing
all authors
publication IDs
|
Derived automatically from this person's publications.
_
People in Profiles who have published with this person.
_
People who share similar concepts with this person.
_
Search Department
_
|