Shu-juan Chen

Title(s)Associate Adjunct Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Huazhong University of Science and TechnologyPh.D
    Huazhong University of Science and TechnologyPharm.D

    Collapse Overview 
    Collapse Overview


    Implementing mouse genetics to examine the mechanisms leading to regulation and expression of the drug processing genes has been the central focus of my research. Derived from my long-term interest in the role of xenobiotic nuclear receptors (NRs) with advancement in deep sequencing technology, my most recent research interest has been further expanded to nuclear receptor corepressor (NCoR1) and its physiological and pharmacological functions during development. I have also been engaged in several other research areas, including developmental brain toxicity, cancer development, and stem cell research.

    Collapse Research 
    Collapse Research Activities and Funding
    The role of nuclear receptor co-repressor NCoR1 in ulcerative colitis
    NIH R21AI135677May 14, 2018 - Apr 30, 2021
    Role: Principal Investigator
    NCoR1 and developmental expression of intestinal xenobiotic processing genes
    NIH R21ES024818Sep 1, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Organ-specific Ugt1 profiling in detoxifying the anticancer drug CPT-11
    NIH R21CA171008Jul 9, 2012 - Jun 30, 2015
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NCoR1 Protects Mice From Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult. Cell Mol Gastroenterol Hepatol. 2020; 10(1):133-147. Mennillo E, Yang X, Paszek M, Auwerx J, Benner C, Chen S. PMID: 32044398; PMCID: PMC7229481.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    2. Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice. Drug Metab Dispos. 2018 11; 46(11):1745-1755. Chen S, Tukey RH. PMID: 30093417; PMCID: PMC6199628.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    3. Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies. Drug Metab Dispos. 2017 07; 45(7):748-754. Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. PMID: 28468837; PMCID: PMC5478905.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    4. Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress. Sci Rep. 2017 04 19; 7:46489. Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey RH. PMID: 28422158; PMCID: PMC5395973.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    5. Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia. Mol Pharmacol. 2017 May; 91(5):545-553. Yueh MF, Chen S, Nguyen N, Tukey RH. PMID: 28283555; PMCID: PMC5416747.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    6. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773; PMCID: PMC5338369.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    7. Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E244-E252. Hinds TD, Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE. PMID: 28096081; PMCID: PMC5406988.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    8. Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 2016 06 15; 110-111:37-46. Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH. PMID: 27060662; PMCID: PMC5010383.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes. J Hepatol. 2016 06; 64(6):1315-26. Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC. PMID: 26921690; PMCID: PMC5010388.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    10. Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia. Mol Pharmacol. 2016 Jan; 89(1):84-93. Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D. PMID: 26480925; PMCID: PMC4702100.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):63-76.e5. Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH. PMID: 26807433; PMCID: PMC4721636.
      View in: PubMed   Mentions: 4     Fields:    
    12. Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol. 2015 Nov 15; 289(1):124-32. Fujiwara R, Maruo Y, Chen S, Tukey RH. PMID: 26342858; PMCID: PMC4708261.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    13. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. PMID: 25404284; PMCID: PMC4260592.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    14. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J Biol Chem. 2014 Feb 21; 289(8):4699-709. Yueh MF, Chen S, Nguyen N, Tukey RH. PMID: 24403077; PMCID: PMC3931032.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    15. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. PMID: 24191041; PMCID: PMC3839688.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    16. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 2012 Aug; 56(2):658-67. Chen S, Yueh MF, Evans RM, Tukey RH. PMID: 22371261; PMCID: PMC3383890.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    17. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. Fujiwara R, Chen S, Karin M, Tukey RH. PMID: 21983082; PMCID: PMC3428231.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    18. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5024-9. Fujiwara R, Nguyen N, Chen S, Tukey RH. PMID: 20194756; PMCID: PMC2841904.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    19. A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation. Drug Metab Dispos. 2010 May; 38(5):879-86. Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC. PMID: 20124398; PMCID: PMC2872941.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    20. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21; 283(12):7901-11. Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH. PMID: 18180294.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    21. Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar; 35(3):419-27. Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. PMID: 17151188.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    22. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci. 2007 Jan; 95(1):98-107. Operaña TN, Nguyen N, Chen S, Beaton D, Tukey RH. PMID: 17065433.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    23. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem. 2005 Nov 11; 280(45):37547-57. Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. PMID: 16155002.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    24. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. Mol Pharmacol. 2005 Apr; 67(4):1247-56. Bonzo JA, Chen S, Galijatovic A, Tukey RH. PMID: 15630080.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    25. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem. 2005 Feb 11; 280(6):4350-9. Chen S, Operaña T, Bonzo J, Nguyen N, Tukey RH. PMID: 15572374.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. PMID: 15037607.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    27. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33. Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. PMID: 12637498.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 2003 Apr 25; 278(17):15001-6. Yueh MF, Huang YH, Hiller A, Chen S, Nguyen N, Tukey RH. PMID: 12566446.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
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