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    Don Cleveland

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0670
    CA La Jolla 92093
    Phone858-534-7811
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      Cleveland is interested in the genes and proteins involved in mitotic spindle assembly and faithful chromosome segregation just prior to division. This process is particularly relevant to the development of cancer because it is thought that cancer cells mis-segregate chromosomes due to errors in mitosis resulting in aneuploidy. The major pathway guarding against whole chromosome mis-segregation is the mitotic checkpoint, a cell cycle control mechanism in which the centromeres of unattached chromosomes generate an inhibitor that blocks cyclin B degradation and advance across mitosis. The antitumor drug taxol is effective by chronically activating this checkpoint. In the past year, starting from all purified components Cleveland’s efforts have reconstructed mitotic checkpoint signaling in vitro. Additionally, abnormalities in number of microtubule organizing centers (centrosomes) can promote errors in spindle formation that lead to subsequent chromosome missegregation and extra centrosomes are associated with many cancers. Like DNA, centrosomes are duplicated only once each cell cycle. The duplication process is governed by polo-like kinase 4 (Plk4). Cleveland’s recent efforts identified how centrosome over-replication is blocked: kinase-mediated, autoregulated instability of Plk4 acts to self-limit Plk4 activity so as to prevent centrosome amplification.

      Clinical Interests
      - Cancer Biology
      - Amyotrophic lateral sclerosis


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      Collapse Bibliographic 
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland D, Lambrechts D, Foijer F, Holland AJ. Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Dev Cell. 2017 Feb 06; 40(3):313-322.e5. PMID: 28132847.
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      2. Fachinetti D, Logsdon GA, Abdullah A, Selzer EB, Cleveland D, Black BE. CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres. Dev Cell. 2017 Jan 09; 40(1):104-113. PMID: 28073008.
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      3. Polymenidou M, Cleveland D. Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. Cold Spring Harb Perspect Med. 2017 Jan 06. PMID: 28062558.
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      4. Jiang J, Cleveland D. Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72. Neuron. 2016 Dec 21; 92(6):1160-1163. PMID: 28009271.
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      5. McMahon MA, Cleveland D. Gene therapy: Gene-editing therapy for neurological disease. Nat Rev Neurol. 2016 Dec 16. PMID: 27982043.
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      6. Hoffmann S, Dumont M, Barra V, Ly P, Nechemia-Arbely Y, McMahon MA, Hervé S, Cleveland D, Fachinetti D. CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly. Cell Rep. 2016 Nov 22; 17(9):2394-2404. PMID: 27880912.
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      7. Taylor JP, Brown RH, Cleveland D. Decoding ALS: from genes to mechanism. Nature. 2016 11 10; 539(7628):197-206. PMID: 27830784.
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      8. Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M. Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. Mol Ther Methods Clin Dev. 2016; 3:16046. PMID: 27462649.
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      9. Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland D, Aguzzi A, Stocker R, Krause KH, Jaquet V. Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radic Biol Med. 2016 Aug; 97:95-108. PMID: 27212019.
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      10. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland D, Lagier-Tourenne C. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 May 4; 90(3):535-50. PMID: 27112497.
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      11. Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland D, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nat Neurosci. 2016 May; 19(5):668-77. PMID: 26998601.
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      12. Da Cruz S, Cleveland D. CELL BIOLOGY. Disrupted nuclear import-export in neurodegeneration. Science. 2016 Jan 8; 351(6269):125-6. PMID: 26744395.
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      13. Quaegebeur A, Segura I, Schmieder R, Verdegem D, Decimo I, Bifari F, Dresselaers T, Eelen G, Ghosh D, Davidson SM, Schoors S, Broekaert D, Cruys B, Govaerts K, De Legher C, Bouché A, Schoonjans L, Ramer MS, Hung G, Bossaert G, Cleveland D, Himmelreich U, Voets T, Lemmens R, Bennett CF, Robberecht W, De Bock K, Dewerchin M, Ghesquière B, Fendt SM, Carmeliet P. Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. Cell Metab. 2016 Feb 9; 23(2):280-91. PMID: 26774962.
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      14. Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, Cleveland D. Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6993-7002. PMID: 26621731.
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      15. Rahdar M, McMahon MA, Prakash TP, Swayze EE, Bennett CF, Cleveland D. Synthetic CRISPR RNA-Cas9-guided genome editing in human cells. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):E7110-7. PMID: 26589814.
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      16. Kulukian A, Holland AJ, Vitre B, Naik S, Cleveland D, Fuchs E. Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6311-20. PMID: 26578791.
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      17. Vitre B, Holland AJ, Kulukian A, Shoshani O, Hirai M, Wang Y, Maldonado M, Cho T, Boubaker J, Swing DA, Tessarollo L, Evans SM, Fuchs E, Cleveland D. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6321-30. PMID: 26578792.
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      18. van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland D, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Boylan KB, Dickson DW, Rademakers R. Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72. Acta Neuropathol. 2015 Dec; 130(6):863-76. PMID: 26437865.
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      19. Gendron TF, van Blitterswijk M, Bieniek KF, Daughrity LM, Jiang J, Rush BK, Pedraza O, Lucas JA, Murray ME, Desaro P, Robertson A, Overstreet K, Thomas CS, Crook JE, Castanedes-Casey M, Rousseau L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Graff-Radford NR, Rademakers R, Lagier-Tourenne C, Edbauer D, Cleveland D, Dickson DW, Petrucelli L, Boylan KB. Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers. Acta Neuropathol. 2015 Oct; 130(4):559-73. PMID: 26350237.
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      20. Topham C, Tighe A, Ly P, Bennett A, Sloss O, Nelson L, Ridgway RA, Huels D, Littler S, Schandl C, Sun Y, Bechi B, Procter DJ, Sansom OJ, Cleveland D, Taylor SS. MYC Is a Major Determinant of Mitotic Cell Fate. Cancer Cell. 2015 Jul 13; 28(1):129-40. PMID: 26175417.
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      21. Mitchell JC, Constable R, So E, Vance C, Scotter E, Glover L, Hortobagyi T, Arnold ES, Ling SC, McAlonis M, Da Cruz S, Polymenidou M, Tessarolo L, Cleveland D, Shaw CE. Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS. Acta Neuropathol Commun. 2015; 3(1):36. PMID: 26108367.
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      22. Fachinetti D, Han JS, McMahon MA, Ly P, Abdullah A, Wong AJ, Cleveland D. DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function. Dev Cell. 2015 May 4; 33(3):314-27. PMID: 25942623.
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      23. Bertuzzi S, Cleveland D. The curious incident of the translational dog that didn't bark. Trends Cell Biol. 2015 Apr; 25(4):187-9. PMID: 25817192.
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      24. Holland AJ, Reis RM, Niessen S, Pereira C, Andres DA, Spielmann HP, Cleveland D, Desai A, Gassmann R. Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors. Mol Biol Cell. 2015 May 15; 26(10):1845-56. PMID: 25808490.
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      25. Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S, Cleveland D. Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1. Neuron. 2015 Apr 8; 86(1):218-32. PMID: 25801706.
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      26. Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland D. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun. 2015; 6:6171. PMID: 25625564.
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      27. Han JS, Vitre B, Fachinetti D, Cleveland D. Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling. Proc Natl Acad Sci U S A. 2014 Oct 7; 111(40):E4185-93. PMID: 25246557.
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      28. Traynor BJ, Cleveland D. Special Issue on amyotrophic lateral sclerosis. Exp Neurol. 2014 Dec; 262 Pt B:73-4. PMID: 25158310.
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      29. Holland AJ, Cleveland D. Polo-like Kinase 4 Inhibition: A Strategy for Cancer Therapy? Cancer Cell. 2014 Aug 11; 26(2):151-3. PMID: 25117704.
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      30. Bodor DL, Mata JF, Sergeev M, David AF, Salimian KJ, Panchenko T, Cleveland D, Black BE, Shah JV, Jansen LE. The quantitative architecture of centromeric chromatin. Elife. 2014; 3:e02137. PMID: 25027692.
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      31. Vitre B, Gudimchuk N, Borda R, Kim Y, Heuser JE, Cleveland D, Grishchuk EL. Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E. Mol Biol Cell. 2014 Aug 1; 25(15):2272-81. PMID: 24920822.
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      32. Mirzaa GM, Vitre B, Carpenter G, Abramowicz I, Gleeson JG, Paciorkowski AR, Cleveland D, Dobyns WB, O'Driscoll M. Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. Hum Genet. 2014 Aug; 133(8):1023-39. PMID: 24748105.
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      33. Cortes CJ, Ling SC, Guo LT, Hung G, Tsunemi T, Ly L, Tokunaga S, Lopez E, Sopher BL, Bennett CF, Shelton GD, Cleveland D, La Spada AR. Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy. Neuron. 2014 Apr 16; 82(2):295-307. PMID: 24742458.
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      34. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland D, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. PMID: 24591593.
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      35. Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland D, Glass CK. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr; 17(4):513-21. PMID: 24584051.
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      36. Lobsiger CS, Cleveland D. Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice. Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1):E5. PMID: 24555201.
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      37. Meyer K, Ferraiuolo L, Miranda CJ, Likhite S, McElroy S, Renusch S, Ditsworth D, Lagier-Tourenne C, Smith RA, Ravits J, Burghes AH, Shaw PJ, Cleveland D, Kolb SJ, Kaspar BK. Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):829-32. PMID: 24379375.
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      38. Parone PA, Da Cruz S, Cleveland D. Mitochondrial Isolation and Purification from Mouse Spinal Cord. Bio Protoc. 2013 Nov 5; 3(21). PMID: 27819013.
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      39. Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland D. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):E4385-92. PMID: 24170856.
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      40. Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland D, Ravits J. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4530-9. PMID: 24170860.
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      41. Silk AD, Zasadil LM, Holland AJ, Vitre B, Cleveland D, Weaver BA. Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):E4134-41. PMID: 24133140.
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      42. Foust KD, Salazar DL, Likhite S, Ferraiuolo L, Ditsworth D, Ilieva H, Meyer K, Schmelzer L, Braun L, Cleveland D, Kaspar BK. Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS. Mol Ther. 2013 Dec; 21(12):2148-59. PMID: 24008656.
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      43. Gudimchuk N, Vitre B, Kim Y, Kiyatkin A, Cleveland D, Ataullakhanov FI, Grishchuk EL. Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. Nat Cell Biol. 2013 Sep; 15(9):1079-88. PMID: 23955301.
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      44. Ling SC, Polymenidou M, Cleveland D. Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron. 2013 Aug 7; 79(3):416-38. PMID: 23931993.
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      45. Earnshaw WC, Cleveland D. CENP-A and the CENP nomenclature: response to Talbert and Henikoff. Trends Genet. 2013 Sep; 29(9):500-2. PMID: 23910159.
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      46. Fachinetti D, Folco HD, Nechemia-Arbely Y, Valente LP, Nguyen K, Wong AJ, Zhu Q, Holland AJ, Desai A, Jansen LE, Cleveland D. A two-step mechanism for epigenetic specification of centromere identity and function. Nat Cell Biol. 2013 Sep; 15(9):1056-66. PMID: 23873148.
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      47. Han JS, Holland AJ, Fachinetti D, Kulukian A, Cetin B, Cleveland D. Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol Cell. 2013 Jul 11; 51(1):92-104. PMID: 23791783.
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      48. Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland D. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr; 21(2):101-6. PMID: 23580138.
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      49. Kang SH, Li Y, Fukaya M, Lorenzini I, Cleveland D, Ostrow LW, Rothstein JD, Bergles DE. Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci. 2013 May; 16(5):571-9. PMID: 23542689.
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      50. Parone PA, Da Cruz S, Han JS, McAlonis-Downes M, Vetto AP, Lee SK, Tseng E, Cleveland D. Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci. 2013 Mar 13; 33(11):4657-71. PMID: 23486940.
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      51. Arnold ES, Ling SC, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone PA, Da Cruz S, Clutario KM, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland D. ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E736-45. PMID: 23382207.
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      52. Holland AJ, Fachinetti D, Zhu Q, Bauer M, Verma IM, Nigg EA, Cleveland D. The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev. 2012 Dec 15; 26(24):2684-9. PMID: 23249732.
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      53. Sun S, Cleveland D. TDP-43 toxicity and the usefulness of junk. Nat Genet. 2012 Dec; 44(12):1289-91. PMID: 23192178.
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      54. Holland AJ, Cleveland D. The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation. J Clin Invest. 2012 Dec 3; 122(12):4325-8. PMID: 23187131.
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      55. Holland AJ, Fachinetti D, Han JS, Cleveland D. Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells. Proc Natl Acad Sci U S A. 2012 Dec 4; 109(49):E3350-7. PMID: 23150568.
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      56. Holland AJ, Cleveland D. Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nat Med. 2012 Nov; 18(11):1630-8. PMID: 23135524.
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      57. Vitre BD, Cleveland D. Centrosomes, chromosome instability (CIN) and aneuploidy. Curr Opin Cell Biol. 2012 Dec; 24(6):809-15. PMID: 23127609.
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      58. Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland D, Yeo GW. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci. 2012 Nov; 15(11):1488-97. PMID: 23023293.
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      59. Yu D, Pendergraff H, Liu J, Kordasiewicz HB, Cleveland D, Swayze EE, Lima WF, Crooke ST, Prakash TP, Corey DR. Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell. 2012 Aug 31; 150(5):895-908. PMID: 22939619.
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      60. Hefferan MP, Galik J, Kakinohana O, Sekerkova G, Santucci C, Marsala S, Navarro R, Hruska-Plochan M, Johe K, Feldman E, Cleveland D, Marsala M. Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. PLoS One. 2012; 7(8):e42614. PMID: 22916141.
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      61. Kordasiewicz HB, Stanek LM, Wancewicz EV, Mazur C, McAlonis MM, Pytel KA, Artates JW, Weiss A, Cheng SH, Shihabuddin LS, Hung G, Bennett CF, Cleveland D. Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21; 74(6):1031-44. PMID: 22726834.
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      62. Holland AJ, Cleveland D. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep. 2012 Jun; 13(6):501-14. PMID: 22565320.
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      63. Polymenidou M, Cleveland D. Prion-like spread of protein aggregates in neurodegeneration. J Exp Med. 2012 May 7; 209(5):889-93. PMID: 22566400.
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      64. Kolano A, Brunet S, Silk AD, Cleveland D, Verlhac MH. Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension. Proc Natl Acad Sci U S A. 2012 Jul 3; 109(27):E1858-67. PMID: 22552228.
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      65. Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland D. Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab. 2012 May 2; 15(5):778-86. PMID: 22560226.
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      66. Nechemia-Arbely Y, Fachinetti D, Cleveland D. Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly. Exp Cell Res. 2012 Jul 15; 318(12):1353-60. PMID: 22561213.
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      67. Holland AJ, Fachinetti D, Da Cruz S, Zhu Q, Vitre B, Lince-Faria M, Chen D, Parish N, Verma IM, Bettencourt-Dias M, Cleveland D. Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Mol Biol Cell. 2012 May; 23(10):1838-45. PMID: 22456511.
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      68. Polymenidou M, Lagier-Tourenne C, Hutt KR, Bennett CF, Cleveland D, Yeo GW. Misregulated RNA processing in amyotrophic lateral sclerosis. Brain Res. 2012 Jun 26; 1462:3-15. PMID: 22444279.
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      69. Polymenidou M, Cleveland D. The seeds of neurodegeneration: prion-like spreading in ALS. Cell. 2011 Oct 28; 147(3):498-508. PMID: 22036560.
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      70. Kolodner RD, Cleveland D, Putnam CD. Cancer. Aneuploidy drives a mutator phenotype in cancer. Science. 2011 Aug 19; 333(6045):942-3. PMID: 21852477.
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      71. Da Cruz S, Cleveland D. Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr Opin Neurobiol. 2011 Dec; 21(6):904-19. PMID: 21813273.
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      72. Vande Velde C, McDonald KK, Boukhedimi Y, McAlonis-Downes M, Lobsiger CS, Bel Hadj S, Zandona A, Julien JP, Shah SB, Cleveland D. Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One. 2011; 6(7):e22031. PMID: 21779368.
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      73. Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland D. Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci. 2011 Apr; 14(4):459-68. PMID: 21358643.
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      74. Black BE, Cleveland D. Epigenetic centromere propagation and the nature of CENP-a nucleosomes. Cell. 2011 Feb 18; 144(4):471-9. PMID: 21335232.
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      75. Li Q, Vande Velde C, Israelson A, Xie J, Bailey AO, Dong MQ, Chun SJ, Roy T, Winer L, Yates JR, Capaldi RA, Cleveland D, Miller TM. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci U S A. 2010 Dec 7; 107(49):21146-51. PMID: 21078990.
        View in: PubMed
      76. Hatch EM, Kulukian A, Holland AJ, Cleveland D, Stearns T. Cep152 interacts with Plk4 and is required for centriole duplication. J Cell Biol. 2010 Nov 15; 191(4):721-9. PMID: 21059850.
        View in: PubMed
      77. Cetin B, Cleveland D. How to survive aneuploidy. Cell. 2010 Oct 1; 143(1):27-9. PMID: 20887888.
        View in: PubMed
      78. Lan W, Cleveland D. Multiclassifier proteomics to define complexes yields new chromosomal proteins. Dev Cell. 2010 Sep 14; 19(3):356-9. PMID: 20833356.
        View in: PubMed
      79. Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V, Cleveland D. Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron. 2010 Aug 26; 67(4):575-87. PMID: 20797535.
        View in: PubMed
      80. Lagier-Tourenne C, Cleveland D. Neurodegeneration: An expansion in ALS genetics. Nature. 2010 Aug 26; 466(7310):1052-3. PMID: 20740002.
        View in: PubMed
      81. Kim Y, Holland AJ, Lan W, Cleveland D. Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell. 2010 Aug 6; 142(3):444-55. PMID: 20691903.
        View in: PubMed
      82. Holland AJ, Lan W, Cleveland D. Centriole duplication: A lesson in self-control. Cell Cycle. 2010 Jul 15; 9(14):2731-6. PMID: 20647763.
        View in: PubMed
      83. Lan W, Cleveland D. A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J Cell Biol. 2010 Jul 12; 190(1):21-4. PMID: 20624898.
        View in: PubMed
      84. Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland D. ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci U S A. 2010 Jul 27; 107(30):13318-23. PMID: 20624952.
        View in: PubMed
      85. Gassmann R, Holland AJ, Varma D, Wan X, Civril F, Cleveland D, Oegema K, Salmon ED, Desai A. Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev. 2010 May; 24(9):957-71. PMID: 20439434.
        View in: PubMed
      86. Lagier-Tourenne C, Polymenidou M, Cleveland D. TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet. 2010 Apr 15; 19(R1):R46-64. PMID: 20400460.
        View in: PubMed
      87. Radulescu AE, Cleveland D. NuMA after 30 years: the matrix revisited. Trends Cell Biol. 2010 Apr; 20(4):214-22. PMID: 20137953.
        View in: PubMed
      88. Holland AJ, Lan W, Niessen S, Hoover H, Cleveland D. Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J Cell Biol. 2010 Jan 25; 188(2):191-8. PMID: 20100909.
        View in: PubMed
      89. Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland D, Taylor SS. Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J Cell Sci. 2010 Feb 1; 123(Pt 3):321-30. PMID: 20053638.
        View in: PubMed
      90. Ilieva H, Polymenidou M, Cleveland D. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol. 2009 Dec 14; 187(6):761-72. PMID: 19951898.
        View in: PubMed
      91. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland D, Zlokovic BV. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49. PMID: 19841542.
        View in: PubMed
      92. Zeitlin SG, Baker NM, Chapados BR, Soutoglou E, Wang JY, Berns MW, Cleveland D. Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15762-7. PMID: 19717431.
        View in: PubMed
      93. Samoshkin A, Arnaoutov A, Jansen LE, Ouspenski I, Dye L, Karpova T, McNally J, Dasso M, Cleveland D, Strunnikov A. Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One. 2009; 4(8):e6831. PMID: 19714251.
        View in: PubMed
      94. Holland AJ, Cleveland D. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol. 2009 Jul; 10(7):478-87. PMID: 19546858.
        View in: PubMed
      95. Weaver BA, Cleveland D. The role of aneuploidy in promoting and suppressing tumors. J Cell Biol. 2009 Jun 15; 185(6):935-7. PMID: 19528293.
        View in: PubMed
      96. Foltz DR, Jansen LE, Bailey AO, Yates JR, Bassett EA, Wood S, Black BE, Cleveland D. Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell. 2009 May 1; 137(3):472-84. PMID: 19410544.
        View in: PubMed
      97. Lagier-Tourenne C, Cleveland D. Rethinking ALS: the FUS about TDP-43. Cell. 2009 Mar 20; 136(6):1001-4. PMID: 19303844.
        View in: PubMed
      98. Silk AD, Holland AJ, Cleveland D. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol. 2009 Mar 9; 184(5):677-90. PMID: 19255246.
        View in: PubMed
      99. Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland D. Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4465-70. PMID: 19251638.
        View in: PubMed
      100. Kulukian A, Han JS, Cleveland D. Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev Cell. 2009 Jan; 16(1):105-17. PMID: 19154722.
        View in: PubMed
      101. Weaver BA, Cleveland D. The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell. 2008 Dec 9; 14(6):431-3. PMID: 19061834.
        View in: PubMed
      102. Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland D. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12599-604. PMID: 18719118.
        View in: PubMed
      103. Holland AJ, Cleveland D. Beyond genetics: surprising determinants of cell fate in antitumor drugs. Cancer Cell. 2008 Aug 12; 14(2):103-5. PMID: 18691543.
        View in: PubMed
      104. Chang Y, Kong Q, Shan X, Tian G, Ilieva H, Cleveland D, Rothstein JD, Borchelt DR, Wong PC, Lin CL. Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS One. 2008; 3(8):e2849. PMID: 18682740.
        View in: PubMed
      105. Dequen F, Bomont P, Gowing G, Cleveland D, Julien JP. Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1. J Neurochem. 2008 Oct; 107(1):253-64. PMID: 18680552.
        View in: PubMed
      106. Polymenidou M, Cleveland D. Motor neuron disease: The curious ways of ALS. Nature. 2008 Jul 17; 454(7202):284-5. PMID: 18633404.
        View in: PubMed
      107. Jelluma N, Brenkman AB, McLeod I, Yates JR, Cleveland D, Medema RH, Kops GJ. Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One. 2008; 3(6):e2415. PMID: 18545697.
        View in: PubMed
      108. Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland D, Goldstein LS. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7594-9. PMID: 18492803.
        View in: PubMed
      109. Kim Y, Heuser JE, Waterman CM, Cleveland D. CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol. 2008 May 5; 181(3):411-9. PMID: 18443223.
        View in: PubMed
      110. Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland D, Zlokovic BV. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2. PMID: 18344992.
        View in: PubMed
      111. Vande Velde C, Miller TM, Cashman NR, Cleveland D. Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):4022-7. PMID: 18296640.
        View in: PubMed
      112. Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland D. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci. 2008 Mar; 11(3):251-3. PMID: 18246065.
        View in: PubMed
      113. Boillée S, Cleveland D. Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. J Clin Invest. 2008 Feb; 118(2):474-8. PMID: 18219386.
        View in: PubMed
      114. Weaver BA, Silk AD, Cleveland D. Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression. Cell Oncol. 2008; 30(5):453. PMID: 18791276.
        View in: PubMed
      115. Lobsiger CS, Cleveland D. Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci. 2007 Nov; 10(11):1355-60. PMID: 17965655.
        View in: PubMed
      116. Weaver BA, Cleveland D. Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res. 2007 Nov 1; 67(21):10103-5. PMID: 17974949.
        View in: PubMed
      117. Detmer SA, Vande Velde C, Cleveland D, Chan DC. Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet. 2008 Feb 1; 17(3):367-75. PMID: 17959936.
        View in: PubMed
      118. Gruzman A, Wood WL, Alpert E, Prasad MD, Miller RG, Rothstein JD, Bowser R, Hamilton R, Wood TD, Cleveland D, Lingappa VR, Liu J. Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12524-9. PMID: 17636119.
        View in: PubMed
      119. Bailey AO, Miller TM, Dong MQ, Vande Velde C, Cleveland D, Yates JR. RCADiA: simple automation platform for comparative multidimensional protein identification technology. Anal Chem. 2007 Aug 15; 79(16):6410-8. PMID: 17616168.
        View in: PubMed
      120. Weaver BA, Cleveland D. Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". Science. 2007 May 18; 316(5827):982; author reply 982. PMID: 17510348.
        View in: PubMed
      121. Rakhit R, Robertson J, Vande Velde C, Horne P, Ruth DM, Griffin J, Cleveland D, Cashman NR, Chakrabartty A. An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nat Med. 2007 Jun; 13(6):754-9. PMID: 17486090.
        View in: PubMed
      122. Conde e Silva N, Black BE, Sivolob A, Filipski J, Cleveland D, Prunell A. CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization. J Mol Biol. 2007 Jul 13; 370(3):555-73. PMID: 17524417.
        View in: PubMed
      123. Lobsiger CS, Boillée S, Cleveland D. Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc Natl Acad Sci U S A. 2007 May 1; 104(18):7319-26. PMID: 17463094.
        View in: PubMed
      124. Black BE, Brock MA, Bédard S, Woods VL, Cleveland D. An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5008-13. PMID: 17360341.
        View in: PubMed
      125. Jansen LE, Black BE, Foltz DR, Cleveland D. Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol. 2007 Mar 12; 176(6):795-805. PMID: 17339380.
        View in: PubMed
      126. Black BE, Jansen LE, Maddox PS, Foltz DR, Desai AB, Shah JV, Cleveland D. Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell. 2007 Jan 26; 25(2):309-22. PMID: 17244537.
        View in: PubMed
      127. Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland D. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 2007 Jan; 11(1):25-36. PMID: 17189716.
        View in: PubMed
      128. Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland D, Kaspar BK. Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19546-51. PMID: 17164329.
        View in: PubMed
      129. Weaver BA, Cleveland D. Does aneuploidy cause cancer? Curr Opin Cell Biol. 2006 Dec; 18(6):658-67. PMID: 17046232.
        View in: PubMed
      130. Boillée S, Vande Velde C, Cleveland D. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron. 2006 Oct 5; 52(1):39-59. PMID: 17015226.
        View in: PubMed
      131. Ross CA, Cleveland D. Intercellular miscommunication in polyglutamine pathogenesis. Nat Neurosci. 2006 Oct; 9(10):1205-6. PMID: 17001335.
        View in: PubMed
      132. Miller TM, Smith RA, Cleveland D. Amyotrophic lateral sclerosis and gene therapy. Nat Clin Pract Neurol. 2006 Sep; 2(9):462-3. PMID: 16932606.
        View in: PubMed
      133. Weaver BA, Silk AD, Cleveland D. Cell biology: nondisjunction, aneuploidy and tetraploidy. Nature. 2006 Aug 17; 442(7104):E9-10; discussion E10. PMID: 16915240.
        View in: PubMed
      134. Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland D. Antisense oligonucleotide therapy for neurodegenerative disease. J Clin Invest. 2006 Aug; 116(8):2290-6. PMID: 16878173.
        View in: PubMed
      135. Yamanaka K, Miller TM, McAlonis-Downes M, Chun SJ, Cleveland D. Progressive spinal axonal degeneration and slowness in ALS2-deficient mice. Ann Neurol. 2006 Jul; 60(1):95-104. PMID: 16802286.
        View in: PubMed
      136. Boillée S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland D. Onset and progression in inherited ALS determined by motor neurons and microglia. Science. 2006 Jun 2; 312(5778):1389-92. PMID: 16741123.
        View in: PubMed
      137. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland D. The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol. 2006 May; 8(5):458-69. PMID: 16622419.
        View in: PubMed
      138. Wang Z, Shah JV, Berns MW, Cleveland D. In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy. Biophys J. 2006 Jul 1; 91(1):343-51. PMID: 16603490.
        View in: PubMed
      139. Yamanaka K, Cleveland D. Determinants of rapid disease progression in ALS. Neurology. 2005 Dec 27; 65(12):1859-60. PMID: 16380607.
        View in: PubMed
      140. Bomont P, Maddox P, Shah JV, Desai AB, Cleveland D. Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J. 2005 Nov 16; 24(22):3927-39. PMID: 16252009.
        View in: PubMed
      141. Kops GJ, Weaver BA, Cleveland D. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer. 2005 Oct; 5(10):773-85. PMID: 16195750.
        View in: PubMed
      142. Mao Y, Desai A, Cleveland D. Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol. 2005 Sep 12; 170(6):873-80. PMID: 16144904.
        View in: PubMed
      143. Garcia ML, Singleton AB, Hernandez D, Ward CM, Evey C, Sapp PA, Hardy J, Brown RH, Cleveland D. Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis. Neurobiol Dis. 2006 Jan; 21(1):102-9. PMID: 16084104.
        View in: PubMed
      144. Lobsiger CS, Garcia ML, Ward CM, Cleveland D. Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10351-6. PMID: 16002469.
        View in: PubMed
      145. Weaver BA, Cleveland D. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell. 2005 Jul; 8(1):7-12. PMID: 16023594.
        View in: PubMed
      146. Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland D. Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):773-6. PMID: 15852369.
        View in: PubMed
      147. Liu J, Shinobu LA, Ward CM, Young D, Cleveland D. Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis. J Neurochem. 2005 May; 93(4):875-82. PMID: 15857390.
        View in: PubMed
      148. Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland D. ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol. 2005 Apr 11; 169(1):49-60. PMID: 15824131.
        View in: PubMed
      149. Miller TM, Cleveland D. Medicine. Treating neurodegenerative diseases with antibiotics. Science. 2005 Jan 21; 307(5708):361-2. PMID: 15661995.
        View in: PubMed
      150. Vande Velde C, Cleveland D. VEGF: multitasking in ALS. Nat Neurosci. 2005 Jan; 8(1):5-7. PMID: 15622408.
        View in: PubMed
      151. Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland D, Goldberg ML, Niu L, Yao X. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J Biol Chem. 2004 Dec 24; 279(52):54590-8. PMID: 15485811.
        View in: PubMed
      152. Lawrence CJ, Dawe RK, Christie KR, Cleveland D, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732.
        View in: PubMed
      153. Black BE, Foltz DR, Chakravarthy S, Luger K, Woods VL, Cleveland D. Structural determinants for generating centromeric chromatin. Nature. 2004 Jul 29; 430(6999):578-82. PMID: 15282608.
        View in: PubMed
      154. Liu J, Lillo C, Jonsson PA, Vande Velde C, Ward CM, Miller TM, Subramaniam JR, Rothstein JD, Marklund S, Andersen PM, Brännström T, Gredal O, Wong PC, Williams DS, Cleveland D. Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron. 2004 Jul 8; 43(1):5-17. PMID: 15233913.
        View in: PubMed
      155. Shah JV, Botvinick E, Bonday Z, Furnari F, Berns M, Cleveland D. Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol. 2004 Jun 8; 14(11):942-52. PMID: 15182667.
        View in: PubMed
      156. Kops GJ, Foltz DR, Cleveland D. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A. 2004 Jun 8; 101(23):8699-704. PMID: 15159543.
        View in: PubMed
      157. Boillée S, Cleveland D. Gene therapy for ALS delivers. Trends Neurosci. 2004 May; 27(5):235-8. PMID: 15111001.
        View in: PubMed
      158. Bruijn LI, Miller TM, Cleveland D. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci. 2004; 27:723-49. PMID: 15217349.
        View in: PubMed
      159. Vande Velde C, Garcia ML, Yin X, Trapp BD, Cleveland D. The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease. Neuromolecular Med. 2004; 5(3):193-203. PMID: 15626820.
        View in: PubMed
      160. Yamanaka K, Vande Velde C, Eymard-Pierre E, Bertini E, Boespflug-Tanguy O, Cleveland D. Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):16041-6. PMID: 14668431.
        View in: PubMed
      161. Garcia ML, Lobsiger CS, Shah SB, Deerinck TJ, Crum J, Young D, Ward CM, Crawford TO, Gotow T, Uchiyama Y, Ellisman MH, Calcutt NA, Cleveland D. NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol. 2003 Dec 8; 163(5):1011-20. PMID: 14662745.
        View in: PubMed
      162. Miller TM, Cleveland D. Has gene therapy for ALS arrived? Nat Med. 2003 Oct; 9(10):1256-7. PMID: 14520369.
        View in: PubMed
      163. Weaver BA, Bonday ZQ, Putkey FR, Kops GJ, Silk AD, Cleveland D. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol. 2003 Aug 18; 162(4):551-63. PMID: 12925705.
        View in: PubMed
      164. Mao Y, Abrieu A, Cleveland D. Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell. 2003 Jul 11; 114(1):87-98. PMID: 12859900.
        View in: PubMed
      165. Xia CH, Roberts EA, Her LS, Liu X, Williams DS, Cleveland D, Goldstein LS. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol. 2003 Apr 14; 161(1):55-66. PMID: 12682084.
        View in: PubMed
      166. Cleveland D, Mao Y, Sullivan KF. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell. 2003 Feb 21; 112(4):407-21. PMID: 12600307.
        View in: PubMed
      167. Raoul C, Estévez AG, Nishimune H, Cleveland D, deLapeyrière O, Henderson CE, Haase G, Pettmann B. Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron. 2002 Sep 12; 35(6):1067-83. PMID: 12354397.
        View in: PubMed
      168. Putkey FR, Cramer T, Morphew MK, Silk AD, Johnson RS, McIntosh JR, Cleveland D. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell. 2002 Sep; 3(3):351-65. PMID: 12361599.
        View in: PubMed
      169. Subramaniam JR, Lyons WE, Liu J, Bartnikas TB, Rothstein J, Price DL, Cleveland D, Gitlin JD, Wong PC. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat Neurosci. 2002 Apr; 5(4):301-7. PMID: 11889469.
        View in: PubMed
      170. Shah JV, Cleveland D. Slow axonal transport: fast motors in the slow lane. Curr Opin Cell Biol. 2002 Feb; 14(1):58-62. PMID: 11792545.
        View in: PubMed
      171. Howland DS, Liu J, She Y, Goad B, Maragakis NJ, Kim B, Erickson J, Kulik J, DeVito L, Psaltis G, DeGennaro LJ, Cleveland D, Rothstein JD. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2002 Feb 5; 99(3):1604-9. PMID: 11818550.
        View in: PubMed
      172. Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland D, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J Biol Chem. 2002 Feb 15; 277(7):4644-8. PMID: 11733539.
        View in: PubMed
      173. Cleveland D, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci. 2001 Nov; 2(11):806-19. PMID: 11715057.
        View in: PubMed
      174. Cleveland D. From Charcot to SOD1: mechanisms of selective motor neuron death in ALS. Neuron. 1999 Nov; 24(3):515-20. PMID: 10595505.
        View in: PubMed
      175. Corson LB, Strain JJ, Culotta VC, Cleveland D. Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6361-6. PMID: 9600970.
        View in: PubMed
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