Melissa Mcalonis -downes

Title(s)	, Cellular and Molecular Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation. Nat Neurosci. 2024 Jan; 27(1):34-47. López-Erauskin J, Bravo-Hernandez M, Presa M, Baughn MW, Melamed Z, Beccari MS, Agra de Almeida Quadros AR, Arnold-Garcia O, Zuberi A, Ling K, Platoshyn O, Niño-Jara E, Ndayambaje IS, McAlonis-Downes M, Cabrera L, Artates JW, Ryan J, Hermann A, Ravits J, Bennett CF, Jafar-Nejad P, Rigo F, Marsala M, Lutz CM, Cleveland DW, Lagier-Tourenne C. PMID: 37996528; PMCID: PMC10842032.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Animals Cells
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease. Proc Natl Acad Sci U S A. 2022 12 06; 119(49):e2123487119. Jambeau M, Meyer KD, Hruska-Plochan M, Tabet R, Lee CZ, Ray-Soni A, Aguilar C, Savage K, Mishra N, Cavegn N, Borter P, Lin CC, Jansen-West KR, Jiang J, Freyermuth F, Li N, De Rossi P, Pérez-Berlanga M, Jiang X, Daughrity LM, Pereira J, Narayanan S, Gu Y, Dhokai S, Dalkilic-Liddle I, Maniecka Z, Weber J, Workman M, McAlonis-Downes M, Berezovski E, Zhang YJ, Berry J, Wainger BJ, Kankel MW, Rushe M, Hock C, Nitsch RM, Cleveland DW, Petrucelli L, Gendron TF, Montrasio F, Grimm J, Polymenidou M, Lagier-Tourenne C. PMID: 36454749; PMCID: PMC9894253.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Humans Animals
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation. Mol Neurodegener. 2021 09 06; 16(1):61. Sanjuan-Ruiz I, Govea-Perez N, McAlonis-Downes M, Dieterle S, Megat S, Dirrig-Grosch S, Picchiarelli G, Piol D, Zhu Q, Myers B, Lee CZ, Cleveland DW, Lagier-Tourenne C, Da Cruz S, Dupuis L. PMID: 34488813; PMCID: PMC8419956.

View in: PubMed Mentions: 4 Fields:
Mol Molecular Biology Neu Neurology
Translation:Humans Animals Cells
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat Neurosci. 2021 08; 24(8):1089-1099. Maimon R, Chillon-Marinas C, Snethlage CE, Singhal SM, McAlonis-Downes M, Ling K, Rigo F, Bennett CF, Da Cruz S, Hnasko TS, Muotri AR, Cleveland DW. PMID: 34083786; PMCID: PMC8338913.

View in: PubMed Mentions: 24 Fields:
Neu Neurology
Translation:Animals Cells
Injury, Illness, and Mental Health Risks in United States Domestic Mariners. J Occup Environ Med. 2020 10; 62(10):839-841. Lefkowitz RY, Null DB, Slade MD, Redlich CA. PMID: 32769797.

View in: PubMed Mentions: 5 Fields:
Env Environmental Health Occ Occupational Medicine
Translation:Humans
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2020 04 22; 106(2):354. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 32325059; PMCID: PMC7184958.

View in: PubMed Mentions: 6 Fields:
Neu Neurology
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nat Neurosci. 2020 05; 23(5):615-624. Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, Da Cruz S, Lagier-Tourenne C, Cleveland DW. PMID: 32284607; PMCID: PMC7384305.

View in: PubMed Mentions: 108 Fields:
Neu Neurology
Translation:Animals Cells
Imaging examination, diagnosis, and control and prevention of nosocomial infection for coronavirus disease 2019: Expert consensus of Hunan radiologist. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28; 45(3):221-228. Liu J, Wang W. PMID: 32386011.

View in: PubMed Mentions: 2 Fields:
Med Medicine (General)
Translation:Humans Cells PHPublic Health
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. Nat Med. 2020 01; 26(1):118-130. Bravo-Hernandez M, Tadokoro T, Navarro MR, Platoshyn O, Kobayashi Y, Marsala S, Miyanohara A, Juhas S, Juhasova J, Skalnikova H, Tomori Z, Vanicky I, Studenovska H, Proks V, Chen P, Govea-Perez N, Ditsworth D, Ciacci JD, Gao S, Zhu W, Ahrens ET, Driscoll SP, Glenn TD, McAlonis-Downes M, Da Cruz S, Pfaff SL, Kaspar BK, Cleveland DW, Marsala M. PMID: 31873312; PMCID: PMC8171115.

View in: PubMed Mentions: 39 Fields:
Med Medicine (General)Mol Molecular Biology
Translation:Humans Animals Cells
An endogenous peptide marker differentiates SOD1 stability and facilitates pharmacodynamic monitoring in SOD1 amyotrophic lateral sclerosis. JCI Insight. 2019 05 16; 4(10). Gertsman I, Wuu J, McAlonis-Downes M, Ghassemian M, Ling K, Rigo F, Bennett F, Benatar M, Miller TM, Da Cruz S. PMID: 31092730; PMCID: PMC6542602.

View in: PubMed Mentions: 3 Fields:
Med Medicine (General)
Translation:Humans Animals
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. Elife. 2019 02 12; 8. Ling SC, Dastidar SG, Tokunaga S, Ho WY, Lim K, Ilieva H, Parone PA, Tyan SH, Tse TM, Chang JC, Platoshyn O, Bui NB, Bui A, Vetto A, Sun S, McAlonis-Downes M, Han JS, Swing D, Kapeli K, Yeo GW, Tessarollo L, Marsala M, Shaw CE, Tucker-Kellogg G, La Spada AR, Lagier-Tourenne C, Da Cruz S, Cleveland DW. PMID: 30747709; PMCID: PMC6389288.

View in: PubMed Mentions: 38 Fields:
Bio Biology
Translation:Humans Animals Cells
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018 11 21; 100(4):816-830.e7. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 30344044; PMCID: PMC6277851.

View in: PubMed Mentions: 105 Fields:
Neu Neurology
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 2017 06; 133(6):907-922. Ditsworth D, Maldonado M, McAlonis-Downes M, Sun S, Seelman A, Drenner K, Arnold E, Ling SC, Pizzo D, Ravits J, Cleveland DW, Da Cruz S. PMID: 28357566; PMCID: PMC5427168.

View in: PubMed Mentions: 40 Fields:
Neu Neurology
Translation:Humans Animals Cells
Misfolded SOD1 is not a primary component of sporadic ALS. Acta Neuropathol. 2017 07; 134(1):97-111. Da Cruz S, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J. PMID: 28247063; PMCID: PMC5472502.

View in: PubMed Mentions: 46 Fields:
Neu Neurology
Translation:Humans Animals Cells
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 05 04; 90(3):535-50. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. PMID: 27112497; PMCID: PMC4860075.

View in: PubMed Mentions: 260 Fields:
Neu Neurology
Translation:Animals Cells
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6993-7002. Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, Cleveland DW. PMID: 26621731; PMCID: PMC4687558.

View in: PubMed Mentions: 99 Fields:
Sci Science
Translation:Humans Animals Cells
Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1. Neuron. 2015 Apr 08; 86(1):218-32. Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S, Cleveland DW. PMID: 25801706; PMCID: PMC4393372.

View in: PubMed Mentions: 56 Fields:
Neu Neurology
Translation:Humans Animals Cells
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):E4385-92. Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW. PMID: 24170856; PMCID: PMC3831990.

View in: PubMed Mentions: 37 Fields:
Sci Science
Translation:Animals Cells
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4530-9. Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. PMID: 24170860; PMCID: PMC3839752.

View in: PubMed Mentions: 317 Fields:
Sci Science
Translation:Animals Cells
Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci. 2013 Mar 13; 33(11):4657-71. Parone PA, Da Cruz S, Han JS, McAlonis-Downes M, Vetto AP, Lee SK, Tseng E, Cleveland DW. PMID: 23486940; PMCID: PMC3711648.

View in: PubMed Mentions: 84 Fields:
Neu Neurology
Translation:Humans Animals Cells
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E736-45. Arnold ES, Ling SC, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone PA, Da Cruz S, Clutario KM, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland DW. PMID: 23382207; PMCID: PMC3581922.

View in: PubMed Mentions: 236 Fields:
Sci Science
Translation:Animals Cells
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab. 2012 May 02; 15(5):778-86. Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW. PMID: 22560226; PMCID: PMC3565468.

View in: PubMed Mentions: 87 Fields:
Cel Cell Biology Met Metabolism
Translation:Humans Animals Cells
Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One. 2011; 6(7):e22031. Vande Velde C, McDonald KK, Boukhedimi Y, McAlonis-Downes M, Lobsiger CS, Bel Hadj S, Zandona A, Julien JP, Shah SB, Cleveland DW. PMID: 21779368; PMCID: PMC3136936.

View in: PubMed Mentions: 65 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4465-70. Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW. PMID: 19251638; PMCID: PMC2657393.

View in: PubMed Mentions: 83 Fields:
Sci Science
Translation:Animals Cells
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7594-9. Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LS. PMID: 18492803; PMCID: PMC2396671.

View in: PubMed Mentions: 140 Fields:
Sci Science
Translation:Animals Cells
Antisense oligonucleotide therapy for neurodegenerative disease. J Clin Invest. 2006 Aug; 116(8):2290-6. Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW. PMID: 16878173; PMCID: PMC1518790.

View in: PubMed Mentions: 216 Fields:
Med Medicine (General)
Translation:Animals Cells
Progressive spinal axonal degeneration and slowness in ALS2-deficient mice. Ann Neurol. 2006 Jul; 60(1):95-104. Yamanaka K, Miller TM, McAlonis-Downes M, Chun SJ, Cleveland DW. PMID: 16802286.

View in: PubMed Mentions: 28 Fields:
Neu Neurology
Translation:Humans Animals Cells