Christopher Steele

Title(s)Staff Res Assoc , Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    1. HRProfiler Detects Homologous Recombination Deficiency in Breast and Ovarian Cancers Using Whole-Genome and Whole-Exome Sequencing Data. Cancer Res. 2025 May 06. Abbasi A, Steele CD, Bergstrom EN, Khandekar A, Farswan A, McKay RR, Pillay N, Alexandrov LB. PMID: 40327608.
      View in: PubMed   Mentions:    Fields:    
    2. Geographic and age variations in mutational processes in colorectal cancer. Nature. 2025 Apr 23. Díaz-Gay M, Dos Santos W, Moody S, Kazachkova M, Abbasi A, Steele CD, Vangara R, Senkin S, Wang J, Fitzgerald S, Bergstrom EN, Khandekar A, Otlu B, Abedi-Ardekani B, de Carvalho AC, Cattiaux T, Penha RCC, Gaborieau V, Chopard P, Carreira C, Cheema S, Latimer C, Teague JW, Mukeriya A, Zaridze D, Cox R, Albert M, Phouthavongsy L, Gallinger S, Malekzadeh R, Niavarani A, Miladinov M, Eric K, Milosavljevic S, Sangrajrang S, Curado MP, Aguiar S, Reis RM, Reis MT, Romagnolo LG, Guimarães DP, Holcatova I, Kalvach J, Vaccaro CA, Piñero TA, Swiatkowska B, Lissowska J, Roszkowska-Purska K, Huertas-Salgado A, Shibata T, Shiba S, Sangkhathat S, Chitapanarux T, Roshandel G, Ashton-Prolla P, Damin DC, de Oliveira FH, Humphreys L, Lawley TD, Perdomo S, Stratton MR, Brennan P, Alexandrov LB. PMID: 40267983.
      View in: PubMed   Mentions:    Fields:    
    3. Geographic and age-related variations in mutational processes in colorectal cancer. medRxiv. 2025 Feb 21. Díaz-Gay M, Dos Santos W, Moody S, Kazachkova M, Abbasi A, Steele CD, Vangara R, Senkin S, Wang J, Fitzgerald S, Bergstrom EN, Khandekar A, Otlu B, Abedi-Ardekani B, de Carvalho AC, Cattiaux T, Penha RCC, Gaborieau V, Chopard P, Carreira C, Cheema S, Latimer C, Teague JW, Mukeriya A, Zaridze D, Cox R, Albert M, Phouthavongsy L, Gallinger S, Malekzadeh R, Niavarani A, Miladinov M, Eric K, Milosavljevic S, Sangrajrang S, Curado MP, Aguiar S, Reis RM, Reis MT, Romagnolo LG, Guimarães DP, Holcatova I, Kalvach J, Vaccaro CA, Piñero TA, Swiatkowska B, Lissowska J, Roszkowska-Purska K, Huertas-Salgado A, Shibata T, Shiba S, Sangkhathat S, Chitapanarux T, Roshandel G, Ashton-Prolla P, Damin DC, de Oliveira FH, Humphreys L, Lawley TD, Perdomo S, Stratton MR, Brennan P, Alexandrov LB. PMID: 40034755; PMCID: PMC11875255.
      View in: PubMed   Mentions:
    4. Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis. bioRxiv. 2025 Jan 22. Durfee C, Bergstrom EN, Díaz-Gay M, Zhou Y, Temiz NA, Ibrahim MA, Nandi SP, Wang Y, Liu X, Steele CD, Proehl J, Vogel RI, Argyris PP, Alexandrov LB, Harris RS. PMID: 39896515; PMCID: PMC11785121.
      View in: PubMed   Mentions:
    5. Detecting HRD in whole-genome and whole-exome sequenced breast and ovarian cancers. medRxiv. 2024 Jul 14. Abbasi A, Steele CD, Bergstrom EN, Khandekar A, Farswan A, Mckay RR, Pillay N, Alexandrov LB. PMID: 39040162; PMCID: PMC11261949.
      View in: PubMed   Mentions:
    6. Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer. Nat Genet. 2024 Jul; 56(7):1420-1433. Kayhanian H, Cross W, van der Horst SEM, Barmpoutis P, Lakatos E, Caravagna G, Zapata L, Van Hoeck A, Middelkamp S, Litchfield K, Steele C, Waddingham W, Patel D, Milite S, Jin C, Baker AM, Alexander DC, Khan K, Hochhauser D, Novelli M, Werner B, van Boxtel R, Hageman JH, Buissant des Amorie JR, Linares J, Ligtenberg MJL, Nagtegaal ID, Laclé MM, Moons LMG, Brosens LAA, Pillay N, Sottoriva A, Graham TA, Rodriguez-Justo M, Shiu KK, Snippert HJG, Jansen M. PMID: 38956208; PMCID: PMC11250277.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. The mutagenic forces shaping the genomic landscape of lung cancer in never smokers. medRxiv. 2024 May 17. Díaz-Gay M, Zhang T, Hoang PH, Khandekar A, Zhao W, Steele CD, Otlu B, Nandi SP, Vangara R, Bergstrom EN, Kazachkova M, Pich O, Swanton C, Hsiung CA, Chang IS, Wong MP, Leung KC, Sang J, McElderry J, Yang L, Nowak MA, Shi J, Rothman N, Wedge DC, Homer R, Yang SR, Lan Q, Zhu B, Chanock SJ, Alexandrov LB, Landi MT. PMID: 38798417; PMCID: PMC11118654.
      View in: PubMed   Mentions:
    8. Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator. BMC Genomics. 2023 Aug 21; 24(1):469. Khandekar A, Vangara R, Barnes M, Díaz-Gay M, Abbasi A, Bergstrom EN, Steele CD, Pillay N, Alexandrov LB. PMID: 37605126; PMCID: PMC10440861.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Mitotic tethering enables inheritance of shattered micronuclear chromosomes. Nature. 2023 Jun; 618(7967):1049-1056. Trivedi P, Steele CD, Au FKC, Alexandrov LB, Cleveland DW. PMID: 37316668; PMCID: PMC10424572.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    10. Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA. Cancer Discov. 2023 03 01; 13(3):654-671. Cortes-Ciriano I, Steele CD, Piculell K, Al-Ibraheemi A, Eulo V, Bui MM, Chatzipli A, Dickson BC, Borcherding DC, Feber A, Galor A, Hart J, Jones KB, Jordan JT, Kim RH, Lindsay D, Miller C, Nishida Y, Proszek PZ, Serrano J, Sundby RT, Szymanski JJ, Ullrich NJ, Viskochil D, Wang X, Snuderl M, Park PJ, Flanagan AM, Hirbe AC, Pillay N, Miller DT, Genomics of MPNST (GeM) Consortium. PMID: 36598417; PMCID: PMC9983734.
      View in: PubMed   Mentions: 27     Fields:    
    11. Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator. bioRxiv. 2023 Feb 04. Khandekar A, Vangara R, Barnes M, Díaz-Gay M, Abbasi A, Bergstrom EN, Steele CD, Pillay N, Alexandrov LB. PMID: 36778452; PMCID: PMC9915726.
      View in: PubMed   Mentions:
    12. Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor. Cell Genom. 2022 Nov 09; 2(11):None. Islam SMA, Díaz-Gay M, Wu Y, Barnes M, Vangara R, Bergstrom EN, He Y, Vella M, Wang J, Teague JW, Clapham P, Moody S, Senkin S, Li YR, Riva L, Zhang T, Gruber AJ, Steele CD, Otlu B, Khandekar A, Abbasi A, Humphreys L, Syulyukina N, Brady SW, Alexandrov BS, Pillay N, Zhang J, Adams DJ, Martincorena I, Wedge DC, Landi MT, Brennan P, Stratton MR, Rozen SG, Alexandrov LB. PMID: 36388765; PMCID: PMC9646490.
      View in: PubMed   Mentions: 125     Fields:    
    13. A genetic model for central chondrosarcoma evolution correlates with patient outcome. Genome Med. 2022 08 30; 14(1):99. Cross W, Lyskjær I, Lesluyes T, Hargreaves S, Strobl AC, Davies C, Waise S, Hames-Fathi S, Oukrif D, Ye H, Amary F, Tirabosco R, Gerrand C, Baker T, Barnes D, Steele C, Alexandrov L, Bond G, Genomics England Research Consortium, Cool P, Pillay N, Van Loo P, Flanagan AM. PMID: 36042521; PMCID: PMC9426036.
      View in: PubMed   Mentions: 8     Fields:    
    14. International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System. J Neurol Surg B Skull Base. 2023 Aug; 84(4):307-319. Lechner M, Takahashi Y, Turri-Zanoni M, Ferrari M, Liu J, Counsell N, Mattavelli D, Rampinelli V, Vermi W, Lombardi D, Saade R, Park KW, Schartinger VH, Franchi A, Facco C, Sessa F, Battocchio S, Fenton TR, Vaz FM, O'Flynn P, Howard D, Stimpson P, Wang S, Hannan SA, Unadkat S, Hughes J, Dwivedi R, Forde CT, Randhawa P, Gane S, Joseph J, Andrews PJ, Dave M, Fleming JC, Thomson D, Zhu T, Teschendorff A, Royle G, Steele C, Jimenez JE, Laco J, Wang EW, Snyderman C, Lacy PD, Woods R, O'Neill JP, Saraswathula A, Kaur RP, Zhao T, Ramanathan M, Gallia GL, London NR, Le QT, West RB, Patel ZM, Nayak JV, Hwang PH, Hermsen M, Llorente J, Facchetti F, Nicolai P, Bossi P, Castelnuovo P, Jay A, Carnell D, Forster MD, Bell DM, Lund VJ, Hanna EY. PMID: 37405239; PMCID: PMC10317567.
      View in: PubMed   Mentions: 12  
    15. Signatures of copy number alterations in human cancer. Nature. 2022 06; 606(7916):984-991. Steele CD, Abbasi A, Islam SMA, Bowes AL, Khandekar A, Haase K, Hames-Fathi S, Ajayi D, Verfaillie A, Dhami P, McLatchie A, Lechner M, Light N, Shlien A, Malkin D, Feber A, Proszek P, Lesluyes T, Mertens F, Flanagan AM, Tarabichi M, Van Loo P, Alexandrov LB, Pillay N. PMID: 35705804; PMCID: PMC9242861.
      View in: PubMed   Mentions: 150     Fields:    
    16. An overview of mutational and copy number signatures in human cancer. J Pathol. 2022 07; 257(4):454-465. Steele CD, Pillay N, Alexandrov LB. PMID: 35420163; PMCID: PMC9324981.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. Nature. 2022 02; 602(7897):510-517. Bergstrom EN, Luebeck J, Petljak M, Khandekar A, Barnes M, Zhang T, Steele CD, Pillay N, Landi MT, Bafna V, Mischel PS, Harris RS, Alexandrov LB. PMID: 35140399; PMCID: PMC8850194.
      View in: PubMed   Mentions: 51     Fields:    
    18. Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma. Eur J Cancer. 2022 02; 162:221-236. Lechner M, Takahashi Y, Turri-Zanoni M, Liu J, Counsell N, Hermsen M, Kaur RP, Zhao T, Ramanathan M, Schartinger VH, Emanuel O, Helman S, Varghese J, Dudas J, Riechelmann H, Sprung S, Haybaeck J, Howard D, Engel NW, Stewart S, Brooks L, Pickles JC, Jacques TS, Fenton TR, Williams L, Vaz FM, O'Flynn P, Stimpson P, Wang S, Hannan SA, Unadkat S, Hughes J, Dwivedi R, Forde CT, Randhawa P, Gane S, Joseph J, Andrews PJ, Royle G, Franchi A, Maragliano R, Battocchio S, Bewicke-Copley H, Pipinikas C, Webster A, Thirlwell C, Ho D, Teschendorff A, Zhu T, Steele CD, Pillay N, Vanhaesebroeck B, Mohyeldin A, Fernandez-Miranda J, Park KW, Le QT, West RB, Saade R, Manes RP, Omay SB, Vining EM, Judson BL, Yarbrough WG, Sansovini M, Silvia N, Grassi I, Bongiovanni A, Capper D, Schüller U, Thavaraj S, Sandison A, Surda P, Hopkins C, Ferrari M, Mattavelli D, Rampinelli V, Facchetti F, Nicolai P, Bossi P, Henriquez OA, Magliocca K, Solares CA, Wise SK, Llorente JL, Patel ZM, Nayak JV, Hwang PH, Lacy PD, Woods R, O'Neill JP, Jay A, Carnell D, Forster MD, Ishii M, London NR, Bell DM, Gallia GL, Castelnuovo P, Severi S, Lund VJ, Hanna EY. PMID: 34980502; PMCID: PMC9554673.
      View in: PubMed   Mentions: 17     Fields:    
    19. Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma. Nat Commun. 2021 12 03; 12(1):7064. Zoumpoulidou G, Alvarez-Mendoza C, Mancusi C, Ahmed RM, Denman M, Steele CD, Tarabichi M, Roy E, Davies LR, Manji J, Cristalli C, Scotlandi K, Pillay N, Strauss SJ, Mittnacht S. PMID: 34862364; PMCID: PMC8642453.
      View in: PubMed   Mentions: 23     Fields:    
    20. Whole-genome sequencing of single circulating tumor cells from neuroendocrine neoplasms. Endocr Relat Cancer. 2021 08 11; 28(9):631-644. Childs A, Steele CD, Vesely C, Rizzo FM, Ensell L, Lowe H, Dhami P, Vaikkinen H, Luong TV, Conde L, Herrero J, Caplin M, Toumpanakis C, Thirlwell C, Hartley JA, Pillay N, Meyer T. PMID: 34280125; PMCID: PMC8428071.
      View in: PubMed   Mentions: 6     Fields:    
    21. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy. Nat Commun. 2021 01 05; 12(1):117. Lechner M, Schartinger VH, Steele CD, Nei WL, Ooft ML, Schreiber LM, Pipinikas CP, Chung GT, Chan YY, Wu F, To KF, Tsang CM, Pearce W, Morelli D, Philpott M, Masterson L, Nibhani R, Wells G, Bell CG, Koller J, Delecluse S, Yip YL, Liu J, Forde CT, Forster MD, Jay A, Dudás J, Krapp A, Wan S, Uprimny C, Sprung S, Haybaeck J, Fenton TR, Chester K, Thirlwell C, Royle G, Marafioti T, Gupta R, Indrasari SR, Herdini C, Slim MAM, Indrawati I, Sutton L, Fles R, Tan B, Yeong J, Jain A, Han S, Wang H, Loke KSH, He W, Xu R, Jin H, Cheng Z, Howard D, Hwang PH, Le QT, Tay JK, West RB, Tsao SW, Meyer T, Riechelmann H, Oppermann U, Delecluse HJ, Willems SM, Chua MLK, Busson P, Lo KW, Wollmann G, Pillay N, Vanhaesebroeck B, Lund VJ. PMID: 33402692; PMCID: PMC7785735.
      View in: PubMed   Mentions: 26     Fields:    
    22. H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours. J Pathol. 2020 10; 252(2):151-164. Lyskjaer I, Lindsay D, Tirabosco R, Steele CD, Lombard P, Strobl AC, Rocha AM, Davies C, Ye H, Bekers E, Ingruber J, Lechner M, Amary F, Pillay N, Flanagan AM. PMID: 32666581; PMCID: PMC8432159.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    23. The genomics of undifferentiated sarcoma of soft tissue: Progress, challenges and opportunities. Semin Cancer Biol. 2020 04; 61:42-55. Steele CD, Pillay N. PMID: 31866474.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    24. Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile. J Pathol. 2019 12; 249(4):425-434. Hofvander J, Puls F, Pillay N, Steele CD, Flanagan AM, Magnusson L, Nilsson J, Mertens F. PMID: 31313299.
      View in: PubMed   Mentions: 13     Fields:    
    25. Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways. Cancer Cell. 2019 03 18; 35(3):441-456.e8. Steele CD, Tarabichi M, Oukrif D, Webster AP, Ye H, Fittall M, Lombard P, Martincorena I, Tarpey PS, Collord G, Haase K, Strauss SJ, Berisha F, Vaikkinen H, Dhami P, Jansen M, Behjati S, Amary MF, Tirabosco R, Feber A, Campbell PJ, Alexandrov LB, Van Loo P, Flanagan AM, Pillay N. PMID: 30889380; PMCID: PMC6428691.
      View in: PubMed   Mentions: 37     Fields:    
    26. Evaluation of low-template DNA profiles using peak heights. Stat Appl Genet Mol Biol. 2016 10 01; 15(5):431-445. Steele CD, Greenhalgh M, Balding DJ. PMID: 27416618.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. Choice of population database for forensic DNA profile analysis. Sci Justice. 2014 Dec; 54(6):487-93. Steele CD, Balding DJ. PMID: 25498938; PMCID: PMC4275602.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. Worldwide F(ST) estimates relative to five continental-scale populations. Ann Hum Genet. 2014 Nov; 78(6):468-77. Steele CD, Court DS, Balding DJ. PMID: 26460400; PMCID: PMC4223938.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    29. Verifying likelihoods for low template DNA profiles using multiple replicates. Forensic Sci Int Genet. 2014 Nov; 13:82-9. Steele CD, Greenhalgh M, Balding DJ. PMID: 25082140; PMCID: PMC4234080.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
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