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Donald Durden

Title(s)Emeritus Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0831
La Jolla CA 92093
Phone8/5-34--3355
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    A Phase I study of a dual PI3K/BRD4 inhibitor, SF1126 in the treatment of hepatocellular carcinoma | IDE: 74,551
    NIH R01FD005113Sep 30, 2016 - Aug 31, 2020
    Role: Principal Investigator
    Maximizing cancer synthetic lethality using dual PI-3K/PARP inhibitors
    NIH R41CA206859Sep 22, 2016 - Sep 19, 2017
    Role: Principal Investigator
    Maximal MYC control using dual PI-3K/BRD4 (kinase/epigenetic) inhibitors
    NIH R41CA192656Apr 8, 2015 - Mar 31, 2016
    Role: Principal Investigator
    Phase 2 Study of Poly-ICLC in the Treatment of Pediatric Low Grade Gliomas
    NIH R01FD004385Sep 5, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Role of Syk and Rac2 in regulation of HIF1alpha and neovascularization.
    NIH R21HL091385Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Role of Rac2 in Development and Function of Blood Cells
    NIH P01HL069974Apr 22, 2002 - Mar 31, 2008
    Role: Co-Investigator
    Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy
    NIH R01CA094233Dec 1, 2001 - Mar 31, 2013
    Role: Principal Investigator
    Vascular targeted pan PI-3kinase inhibitor prodrug, SF1126 for glioma therapy.
    NIH R56CA094233Dec 1, 2001 - Jun 30, 2009
    Role: Principal Investigator
    Biology and Therapy of High Risk Neuroblastoma
    NIH/NCI P01CA081403Jul 6, 2000 - May 31, 2015
    Role: Co-Investigator
    PHASE II STUDY FOR TREATMENT OF PEDIATRIC BRAIN TUMORS
    NIH R01CA075637Sep 15, 1997 - Jul 31, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020; 6:49. Burgoyne AM, Vann KR, Joshi S, Morales GA, Vega FM, Singh A, Pal D, Merati AB, Kutateladze TG, Durden DL. PMID: 32793389.
      View in: PubMed   Mentions:
    2. Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep. 2020 Jul 21; 10(1):12027. Vann KR, Pal D, Morales GA, Burgoyne AM, Durden DL, Kutateladze TG. PMID: 32694708.
      View in: PubMed   Mentions:    Fields:    
    3. Macrophage Syk-PI3K? Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression. Mol Cancer Ther. 2020 03; 19(3):755-764. Joshi S, Liu KX, Zulcic M, Singh AR, Skola D, Glass CK, Sanders PD, Sharabi AB, Pham TV, Tamayo P, Shiang D, Dinh HQ, Hedrick CC, Morales GA, Garlich JR, Durden DL. PMID: 31974273.
      View in: PubMed   Mentions:    Fields:    
    4. Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. PLoS One. 2019; 14(9):e0214901. Chahal KK, Li J, Kufareva I, Parle M, Durden DL, Wechsler-Reya RJ, Chen CC, Abagyan R. PMID: 31539380.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Hypoxia-induced PIM kinase and laminin-activated integrin a6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC. Am J Clin Exp Urol. 2019; 7(4):297-312. Toth RK, Tran JD, Muldong MT, Nollet EA, Schulz VV, Jensen CC, Hazlehurst LA, Corey E, Durden D, Jamieson C, Miranti CK, Warfel NA. PMID: 31511835.
      View in: PubMed   Mentions:
    6. SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer. Mol Cancer Ther. 2019 06; 18(6):1036-1044. Joshi S, Singh AR, Liu KX, Pham TV, Zulcic M, Skola D, Chun HB, Glass CK, Morales GA, Garlich JR, Durden DL. PMID: 31018997.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System. J Oncol. 2019; 2019:5245034. Joshi S, Durden DL. PMID: 30853982.
      View in: PubMed   Mentions:
    8. Erratum to: Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice. Thromb Haemost. 2019 09; 119(9):1546. Cooke EJ, Zhou JY, Wyseure T, Joshi S, Bhat V, Durden DL, Mosnier LO, von Drygalski A. PMID: 30071568.
      View in: PubMed   Mentions:    Fields:    
    9. Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice. Thromb Haemost. 2018 06; 118(6):1036-1047. Cooke EJ, Zhou JY, Wyseure T, Joshi S, Bhat V, Durden DL, Mosnier LO, von Drygalski A. PMID: 29847841.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication. J Biol Chem. 2018 04 20; 293(16):5808-5820. Campbell GR, Bruckman RS, Herns SD, Joshi S, Durden DL, Spector SA. PMID: 29475942.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    11. Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype. PLoS One. 2017; 12(8):e0182851. Joshi S, Singh AR, Wong SS, Zulcic M, Jiang M, Pardo A, Selman M, Hagood JS, Durden DL. PMID: 28817691.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity. Sci Rep. 2017 01 31; 7:41643. Nguyen HA, Durden DL, Lavie A. PMID: 28139703.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):E1072-E1080. Andrews FH, Singh AR, Joshi S, Smith CA, Morales GA, Garlich JR, Durden DL, Kutateladze TG. PMID: 28137841.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    14. Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget. 2017 Aug 08; 8(32):52193-52210. Erdreich-Epstein A, Singh AR, Joshi S, Vega FM, Guo P, Xu J, Groshen S, Ye W, Millard M, Campan M, Morales G, Garlich JR, Laird PW, Seeger RC, Shimada H, Durden DL. PMID: 28881723.
      View in: PubMed   Mentions: 3     Fields:    
    15. Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma. Mol Cancer Ther. 2016 11; 15(11):2553-2562. Singh AR, Joshi S, Burgoyne AM, Sicklick JK, Ikeda S, Kono Y, Garlich JR, Morales GA, Durden DL. PMID: 27496136.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    16. PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma. PLoS One. 2016; 11(3):e0150836. Singh AR, Joshi S, Zulcic M, Alcaraz M, Garlich JR, Morales GA, Cho YJ, Bao L, Levy ML, Newbury R, Malicki D, Messer K, Crawford J, Durden DL. PMID: 26938241.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release. PLoS One. 2015; 10(10):e0140585. Ishii Y, Nhiayi MK, Tse E, Cheng J, Massimino M, Durden DL, Vigneri P, Wang JY. PMID: 26473951.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Vascular remodeling underlies rebleeding in hemophilic arthropathy. Am J Hematol. 2015 Nov; 90(11):1027-35. Bhat V, Olmer M, Joshi S, Durden DL, Cramer TJ, Barnes RF, Ball ST, Hughes TH, Silva M, Luck JV, Moore RE, Mosnier LO, von Drygalski A. PMID: 26257191.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    19. Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma. Cancer Chemother Pharmacol. 2015 Mar; 75(3):595-608. Joshi S, Singh AR, Durden DL. PMID: 25578041.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    20. Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12)?V-Ha-Ras transgenic mouse glioma model. Cancer Cell Int. 2014; 14(1):105. Singh AR, Joshi S, George E, Durden DL. PMID: 25425962.
      View in: PubMed   Mentions:
    21. A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1a and HIF2a stability and tumor growth, angiogenesis, and metastasis. Mol Cancer Res. 2014 Oct; 12(10):1520-31. Joshi S, Singh AR, Zulcic M, Durden DL. PMID: 25103499.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    22. Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors. J Pediatr Hematol Oncol. 2014 Aug; 36(6):451-7. Hartman LL, Crawford JR, Makale MT, Milburn M, Joshi S, Salazar AM, Hasenauer B, VandenBerg SR, MacDonald TJ, Durden DL. PMID: 24309609.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    23. MDM2 regulates hypoxic hypoxia-inducible factor 1a stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner. J Biol Chem. 2014 Aug 15; 289(33):22785-97. Joshi S, Singh AR, Durden DL. PMID: 24982421.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    24. PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment. Exp Cell Res. 2014 Sep 10; 327(1):78-90. Singh AR, Peirce SK, Joshi S, Durden DL. PMID: 24881819.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    25. A PKC-SHP1 signaling axis desensitizes Fc? receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates Fc?R mediated phagocytosis. BMC Immunol. 2014 May 07; 15:18. Joshi S, Singh AR, Zulcic M, Durden DL. PMID: 24886428.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo. PLoS One. 2014; 9(4):e95893. Joshi S, Singh AR, Zulcic M, Bao L, Messer K, Ideker T, Dutkowski J, Durden DL. PMID: 24770346.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    27. PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1a suppression. J Neurooncol. 2014 Jan; 116(1):89-97. Muh CR, Joshi S, Singh AR, Kesari S, Durden DL, Makale MT. PMID: 24162827.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors. J Med Chem. 2013 Mar 14; 56(5):1922-39. Morales GA, Garlich JR, Su J, Peng X, Newblom J, Weber K, Durden DL. PMID: 23410005.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo. Cancer Chemother Pharmacol. 2013 Apr; 71(4):867-81. De P, Dey N, Terakedis B, Bergsagel PL, Li ZH, Mahadevan D, Garlich JR, Trudel S, Makale MT, Durden DL. PMID: 23355037.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    30. Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene. 2013 Aug 29; 32(35):4181-8. Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ. PMID: 23045271.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    31. Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies. Eur J Cancer. 2012 Dec; 48(18):3319-27. Mahadevan D, Chiorean EG, Harris WB, Von Hoff DD, Stejskal-Barnett A, Qi W, Anthony SP, Younger AE, Rensvold DM, Cordova F, Shelton CF, Becker MD, Garlich JR, Durden DL, Ramanathan RK. PMID: 22921184.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCTClinical Trials
    32. The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention. Cancer Chemother Pharmacol. 2011 Aug; 68(2):325-35. Peirce SK, Findley HW, Prince C, Dasgupta A, Cooper T, Durden DL. PMID: 20972874.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma. PLoS One. 2010 May 26; 5(5):e10849. Castellino RC, Barwick BG, Schniederjan M, Buss MC, Becher O, Hambardzumyan D, Macdonald TJ, Brat DJ, Durden DL. PMID: 20520772.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    34. PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells. BMC Cancer. 2009 Nov 25; 9:411. Crosswell HE, Dasgupta A, Alvarado CS, Watt T, Christensen JG, De P, Durden DL, Findley HW. PMID: 19939254.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    35. In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells. Cancer Chemother Pharmacol. 2010 Mar; 65(4):697-706. Ozbay T, Durden DL, Liu T, O'Regan RM, Nahta R. PMID: 19636556.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    36. Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell. 2009 May 05; 15(5):363-75. Gu L, Zhu N, Zhang H, Durden DL, Feng Y, Zhou M. PMID: 19411066.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    37. Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. Cancer Res. 2009 Mar 15; 69(6):2540-9. Rong Y, Belozerov VE, Tucker-Burden C, Chen G, Durden DL, Olson JJ, Van Meir EG, Mackman N, Brat DJ. PMID: 19276385.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    38. Expression of RAC2 in endothelial cells is required for the postnatal neovascular response. Exp Cell Res. 2009 Jan 15; 315(2):248-63. De P, Peng Q, Traktuev DO, Traktuevc DO, Li W, Yoder MC, March KL, Durden DL. PMID: 19123268.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    39. PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis. Curr Pharm Des. 2009; 15(4):380-8. Castellino RC, Muh CR, Durden DL. PMID: 19199965.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    40. The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res. 2008 Mar 15; 68(6):1862-71. Dey N, Crosswell HE, De P, Parsons R, Peng Q, Su JD, Durden DL. PMID: 18339867.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    41. A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res. 2008 Jan 01; 68(1):206-15. Garlich JR, De P, Dey N, Su JD, Peng X, Miller A, Murali R, Lu Y, Mills GB, Kundra V, Shu HK, Peng Q, Durden DL. PMID: 18172313.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    42. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol. 2007 Dec 15; 179(12):8322-31. Li Y, Yan J, De P, Chang HC, Yamauchi A, Christopherson KW, Paranavitana NC, Peng X, Kim C, Munugalavadla V, Munugulavadla V, Kapur R, Chen H, Shou W, Stone JC, Kaplan MH, Dinauer MC, Durden DL, Quilliam LA. PMID: 18056377.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    43. Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors. Nat Clin Pract Neurol. 2007 Dec; 3(12):682-93. Castellino RC, Durden DL. PMID: 18046441.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    44. CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation. Mol Cell Biol. 2007 Jun; 27(11):4179-97. Dey N, De PK, Wang M, Zhang H, Dobrota EA, Robertson KA, Durden DL. PMID: 17325034.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    45. A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth. Oncogene. 2007 Jun 07; 26(27):3930-40. Denning G, Jean-Joseph B, Prince C, Durden DL, Vogt PK. PMID: 17213812.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    46. Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. J Biol Chem. 2006 Oct 20; 281(42):31222-33. Reinert RB, Oberle LM, Wek SA, Bunpo P, Wang XP, Mileva I, Goodwin LO, Aldrich CJ, Durden DL, McNurlan MA, Wek RC, Anthony TG. PMID: 16931516.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    47. Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms. Cancer Res. 2006 Jul 15; 66(14):7067-74. Rong Y, Hu F, Huang R, Mackman N, Horowitz JM, Jensen RL, Durden DL, Van Meir EG, Brat DJ. PMID: 16849552.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    48. 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol. 2006 Jun; 65(6):529-39. Rong Y, Durden DL, Van Meir EG, Brat DJ. PMID: 16783163.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimals
    49. CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity. Exp Cell Res. 2005 Jul 01; 307(1):1-14. Dey N, Howell BW, De PK, Durden DL. PMID: 15890337.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    50. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res. 2005 Feb 15; 65(4):1406-13. Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG, Brat DJ. PMID: 15735028.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    51. Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. J Biol Chem. 2005 Jan 14; 280(2):1543-51. Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML, Geahlen RL. PMID: 15536084.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    52. Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase. J Biol Chem. 2003 Oct 24; 278(43):41661-9. Pradip D, Peng X, Durden DL. PMID: 12917394.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    53. PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. Cancer Res. 2003 Jul 01; 63(13):3585-92. Su JD, Mayo LD, Donner DB, Durden DL. PMID: 12839945.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    54. Ceramide signaling in fenretinide-induced endothelial cell apoptosis. J Biol Chem. 2002 Dec 20; 277(51):49531-7. Erdreich-Epstein A, Tran LB, Bowman NN, Wang H, Cabot MC, Durden DL, Vlckova J, Reynolds CP, Stins MF, Groshen S, Millard M. PMID: 12388538.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    55. SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC. Blood. 2002 Sep 01; 100(5):1852-9. Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL. PMID: 12176909.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    56. PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac. Blood. 2002 Jan 15; 99(2):694-7. Kim JS, Peng X, De PK, Geahlen RL, Durden DL. PMID: 11781256.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    57. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem. 2002 Feb 15; 277(7):5484-9. Mayo LD, Dixon JE, Durden DL, Tonks NK, Donner DB. PMID: 11729185.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    58. Treatment of collagen induced arthritis in DBA/1 mice with L-asparaginase. Clin Exp Rheumatol. 2001 Nov-Dec; 19(6):639-46. Reiff A, Zastrow M, Sun BC, Takei S, Mitsuhada H, Bernstein B, Durden DL. PMID: 11791634.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    59. Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin. Cancer Res. 2001 Jul 15; 61(14):5587-94. Isogai C, Laug WE, Shimada H, Declerck PJ, Stins MF, Durden DL, Erdreich-Epstein A, DeClerck YA. PMID: 11454712.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    60. PTEN controls tumor-induced angiogenesis. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4622-7. Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, Tonks NK, Durden DL. PMID: 11274365.
      View in: PubMed   Mentions: 72     Fields:    
    61. Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide. Cancer Res. 2000 Feb 01; 60(3):712-21. Erdreich-Epstein A, Shimada H, Groshen S, Liu M, Metelitsa LS, Kim KS, Stins MF, Seeger RC, Durden DL. PMID: 10676658.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    62. High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase. J Immunol. 1999 Dec 01; 163(11):6023-34. Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL. PMID: 10570290.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    63. Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling. Blood. 1999 Sep 15; 94(6):2112-20. Park RK, Izadi KD, Deo YM, Durden DL. PMID: 10477741.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    64. Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages. J Leukoc Biol. 1999 Apr; 65(4):523-34. Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL. PMID: 10204582.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    65. Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling. Exp Cell Res. 1998 Dec 15; 245(2):330-42. Izadi KD, Erdreich-Epstein A, Liu Y, Durden DL. PMID: 9851874.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    66. Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI). J Immunol. 1998 Nov 15; 161(10):5555-63. Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL. PMID: 9820532.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
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