Donald Durden

Title(s)Emeritus Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dual PI3K/BRD4 Inhibitory Chemotype for Maximum Inhibition of MYC and Cancer
    NIH R01CA215651Dec 27, 2017 - Jul 31, 2024
    Role: Principal Investigator
    Role of PTEN and PI-3 Kinase in Medulloblastomagenesis
    NIH R01CA172513Jul 3, 2017 - May 31, 2023
    Role: Principal Investigator
    A Phase I study of a dual PI3K/BRD4 inhibitor, SF1126 in the treatment of hepatocellular carcinoma IDE: 74,551
    NIH R01FD005113Sep 30, 2016 - Aug 31, 2020
    Role: Principal Investigator
    Maximizing cancer synthetic lethality using dual PI-3K/PARP inhibitors
    NIH R41CA206859Sep 22, 2016 - Dec 19, 2017
    Role: Principal Investigator
    Maximal MYC control using dual PI-3K/BRD4 (kinase/epigenetic) inhibitors
    NIH R41CA192656Apr 8, 2015 - Jun 30, 2016
    Role: Principal Investigator
    Phase 2 Study of Poly-ICLC in the Treatment of Pediatric Low Grade Gliomas
    NIH R01FD004385Sep 5, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Role of Syk and Rac2 in regulation of HIF1alpha and neovascularization.
    NIH R21HL091385Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Role of Rac2 in Development and Function of Blood Cells
    NIH P01HL069974Apr 22, 2002 - Mar 31, 2008
    Role: Co-Investigator
    Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy
    NIH R01CA094233Dec 1, 2001 - Mar 31, 2013
    Role: Principal Investigator
    Vascular targeted pan PI-3kinase inhibitor prodrug, SF1126 for glioma therapy.
    NIH R56CA094233Dec 1, 2001 - Jun 30, 2009
    Role: Principal Investigator
    Biology and Therapy of High Risk Neuroblastoma
    NIH/NCI P01CA081403Jul 6, 2000 - May 31, 2015
    Role: Co-Investigator
    NIH R01CA075637Sep 15, 1997 - Jul 31, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection. Structure. 2022 09 01; 30(9):1224-1232.e5. Vann KR, Acharya A, Jang SM, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, Côté J, Byrareddy SN, Kutateladze TG. PMID: 35716662; PMCID: PMC9212912.
      View in: PubMed   Mentions:    Fields:    
    2. PI3K-α/mTOR/BRD4 inhibitor alone or in combination with other anti-virals blocks replication of SARS-CoV-2 and its variants of concern including Delta and Omicron. Clin Transl Med. 2022 04; 12(4):e806. Acharya A, Pathania AS, Pandey K, Thurman M, Vann KR, Kutateladze TG, Challagundala KB, Durden DL, Byrareddy SN. PMID: 35390226; PMCID: PMC8989379.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Preclinical Evaluation of a Novel Dual Targeting PI3Kδ/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia. Front Oncol. 2021; 11:766888. Ruan Y, Kim HN, Ogana HA, Wan Z, Hurwitz S, Nichols C, Abdel-Azim N, Coba A, Seo S, Loh YE, Gang EJ, Abdel-Azim H, Hsieh CL, Lieber MR, Parekh C, Pal D, Bhojwani D, Durden DL, Kim YM. PMID: 34926269; PMCID: PMC8671162.
      View in: PubMed   Mentions:
    4. The BTK/PI3K/BRD4 axis inhibitor SRX3262 overcomes Ibrutinib resistance in mantle cell lymphoma. iScience. 2021 Sep 24; 24(9):102931. Pal D, Vann KR, Joshi S, Sahar NE, Morales GA, El-Gamal D, Kutateladze TG, Durden DL. PMID: 34557659; PMCID: PMC8445847.
      View in: PubMed   Mentions: 2  
    5. Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma. J Pediatr Hematol Oncol. 2021 04 01; 43(3):e304-e311. Goldin AN, Singh A, Joshi S, Jamieson C, Durden DL. PMID: 33480647.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor. bioRxiv. 2021 Mar 05. Acharya A, Pandey K, Thurman M, Challagundala KB, Vann KR, Kutateladze TG, Morales GA, Durden DL, Byrareddy SN. PMID: 33688653; PMCID: PMC7941624.
      View in: PubMed   Mentions: 2  
    7. COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges. Theranostics. 2021; 11(2):731-753. Pathania AS, Prathipati P, Abdul BA, Chava S, Katta SS, Gupta SC, Gangula PR, Pandey MK, Durden DL, Byrareddy SN, Challagundla KB. PMID: 33391502; PMCID: PMC7738845.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsPHPublic Health
    8. Amino Acids Regulate Cisplatin Insensitivity in Neuroblastoma. Cancers (Basel). 2020 Sep 10; 12(9). Gunda V, Pathania AS, Chava S, Prathipati P, Chaturvedi NK, Coulter DW, Pandey MK, Durden DL, Challagundla KB. PMID: 32927667; PMCID: PMC7563727.
      View in: PubMed   Mentions: 7  
    9. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020; 6(1):49. Burgoyne AM, Vann KR, Joshi S, Morales GA, Vega FM, Singh A, Pal D, Merati AB, Kutateladze TG, Durden DL. PMID: 32793389; PMCID: PMC7385619.
      View in: PubMed   Mentions: 3  
    10. Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep. 2020 07 21; 10(1):12027. Vann KR, Pal D, Morales GA, Burgoyne AM, Durden DL, Kutateladze TG. PMID: 32694708; PMCID: PMC7374098.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression. Mol Cancer Ther. 2020 03; 19(3):755-764. Joshi S, Liu KX, Zulcic M, Singh AR, Skola D, Glass CK, Sanders PD, Sharabi AB, Pham TV, Tamayo P, Shiang D, Dinh HQ, Hedrick CC, Morales GA, Garlich JR, Durden DL. PMID: 31974273; PMCID: PMC7450492.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. PLoS One. 2019; 14(9):e0214901. Chahal KK, Li J, Kufareva I, Parle M, Durden DL, Wechsler-Reya RJ, Chen CC, Abagyan R. PMID: 31539380; PMCID: PMC6754133.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC. Am J Clin Exp Urol. 2019; 7(4):297-312. Toth RK, Tran JD, Muldong MT, Nollet EA, Schulz VV, Jensen CC, Hazlehurst LA, Corey E, Durden D, Jamieson C, Miranti CK, Warfel NA. PMID: 31511835; PMCID: PMC6734039.
      View in: PubMed   Mentions: 8  
    14. SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer. Mol Cancer Ther. 2019 06; 18(6):1036-1044. Joshi S, Singh AR, Liu KX, Pham TV, Zulcic M, Skola D, Chun HB, Glass CK, Morales GA, Garlich JR, Durden DL. PMID: 31018997; PMCID: PMC6893301.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System. J Oncol. 2019; 2019:5245034. Joshi S, Durden DL. PMID: 30853982; PMCID: PMC6377965.
      View in: PubMed   Mentions: 34  
    16. Erratum to: Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice. Thromb Haemost. 2019 09; 119(9):1546. Cooke EJ, Zhou JY, Wyseure T, Joshi S, Bhat V, Durden DL, Mosnier LO, von Drygalski A. PMID: 30071568.
      View in: PubMed   Mentions:    Fields:    
    17. Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice. Thromb Haemost. 2018 06; 118(6):1036-1047. Cooke EJ, Zhou JY, Wyseure T, Joshi S, Bhat V, Durden DL, Mosnier LO, von Drygalski A. PMID: 29847841; PMCID: PMC6191040.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    18. Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication. J Biol Chem. 2018 04 20; 293(16):5808-5820. Campbell GR, Bruckman RS, Herns SD, Joshi S, Durden DL, Spector SA. PMID: 29475942; PMCID: PMC5912471.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    19. Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype. PLoS One. 2017; 12(8):e0182851. Joshi S, Singh AR, Wong SS, Zulcic M, Jiang M, Pardo A, Selman M, Hagood JS, Durden DL. PMID: 28817691; PMCID: PMC5560537.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity. Sci Rep. 2017 01 31; 7:41643. Nguyen HA, Durden DL, Lavie A. PMID: 28139703; PMCID: PMC5282591.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    21. Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):E1072-E1080. Andrews FH, Singh AR, Joshi S, Smith CA, Morales GA, Garlich JR, Durden DL, Kutateladze TG. PMID: 28137841; PMCID: PMC5320964.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    22. Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget. 2017 Aug 08; 8(32):52193-52210. Erdreich-Epstein A, Singh AR, Joshi S, Vega FM, Guo P, Xu J, Groshen S, Ye W, Millard M, Campan M, Morales G, Garlich JR, Laird PW, Seeger RC, Shimada H, Durden DL. PMID: 28881723; PMCID: PMC5581022.
      View in: PubMed   Mentions: 14     Fields:    
    23. Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma. Mol Cancer Ther. 2016 11; 15(11):2553-2562. Singh AR, Joshi S, Burgoyne AM, Sicklick JK, Ikeda S, Kono Y, Garlich JR, Morales GA, Durden DL. PMID: 27496136; PMCID: PMC5278767.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    24. PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma. PLoS One. 2016; 11(3):e0150836. Singh AR, Joshi S, Zulcic M, Alcaraz M, Garlich JR, Morales GA, Cho YJ, Bao L, Levy ML, Newbury R, Malicki D, Messer K, Crawford J, Durden DL. PMID: 26938241; PMCID: PMC4777592.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    25. Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release. PLoS One. 2015; 10(10):e0140585. Ishii Y, Nhiayi MK, Tse E, Cheng J, Massimino M, Durden DL, Vigneri P, Wang JY. PMID: 26473951; PMCID: PMC4608728.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    26. Vascular remodeling underlies rebleeding in hemophilic arthropathy. Am J Hematol. 2015 Nov; 90(11):1027-35. Bhat V, Olmer M, Joshi S, Durden DL, Cramer TJ, Barnes RF, Ball ST, Hughes TH, Silva M, Luck JV, Moore RE, Mosnier LO, von Drygalski A. PMID: 26257191; PMCID: PMC4618067.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    27. Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma. Cancer Chemother Pharmacol. 2015 Mar; 75(3):595-608. Joshi S, Singh AR, Durden DL. PMID: 25578041.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    28. Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model. Cancer Cell Int. 2014; 14(1):105. Singh AR, Joshi S, George E, Durden DL. PMID: 25425962; PMCID: PMC4243316.
      View in: PubMed   Mentions: 9  
    29. A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis. Mol Cancer Res. 2014 Oct; 12(10):1520-31. Joshi S, Singh AR, Zulcic M, Durden DL. PMID: 25103499.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    30. Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors. J Pediatr Hematol Oncol. 2014 Aug; 36(6):451-7. Hartman LL, Crawford JR, Makale MT, Milburn M, Joshi S, Salazar AM, Hasenauer B, VandenBerg SR, MacDonald TJ, Durden DL. PMID: 24309609; PMCID: PMC4356196.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    31. MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner. J Biol Chem. 2014 Aug 15; 289(33):22785-22797. Joshi S, Singh AR, Durden DL. PMID: 24982421; PMCID: PMC4132784.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    32. PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment. Exp Cell Res. 2014 Sep 10; 327(1):78-90. Singh AR, Peirce SK, Joshi S, Durden DL. PMID: 24881819.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis. BMC Immunol. 2014 May 07; 15:18. Joshi S, Singh AR, Zulcic M, Durden DL. PMID: 24886428; PMCID: PMC4017086.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo. PLoS One. 2014; 9(4):e95893. Joshi S, Singh AR, Zulcic M, Bao L, Messer K, Ideker T, Dutkowski J, Durden DL. PMID: 24770346; PMCID: PMC4000195.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    35. PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. J Neurooncol. 2014 Jan; 116(1):89-97. Muh CR, Joshi S, Singh AR, Kesari S, Durden DL, Makale MT. PMID: 24162827; PMCID: PMC3896301.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    36. Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors. J Med Chem. 2013 Mar 14; 56(5):1922-39. Morales GA, Garlich JR, Su J, Peng X, Newblom J, Weber K, Durden DL. PMID: 23410005.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    37. An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo. Cancer Chemother Pharmacol. 2013 Apr; 71(4):867-81. De P, Dey N, Terakedis B, Bergsagel PL, Li ZH, Mahadevan D, Garlich JR, Trudel S, Makale MT, Durden DL. PMID: 23355037; PMCID: PMC3832139.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    38. Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene. 2013 Aug 29; 32(35):4181-8. Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ. PMID: 23045271; PMCID: PMC3808889.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies. Eur J Cancer. 2012 Dec; 48(18):3319-27. Mahadevan D, Chiorean EG, Harris WB, Von Hoff DD, Stejskal-Barnett A, Qi W, Anthony SP, Younger AE, Rensvold DM, Cordova F, Shelton CF, Becker MD, Garlich JR, Durden DL, Ramanathan RK. PMID: 22921184; PMCID: PMC3826796.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCTClinical Trials
    40. The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention. Cancer Chemother Pharmacol. 2011 Aug; 68(2):325-35. Peirce SK, Findley HW, Prince C, Dasgupta A, Cooper T, Durden DL. PMID: 20972874; PMCID: PMC3143317.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    41. Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma. PLoS One. 2010 May 26; 5(5):e10849. Castellino RC, Barwick BG, Schniederjan M, Buss MC, Becher O, Hambardzumyan D, Macdonald TJ, Brat DJ, Durden DL. PMID: 20520772; PMCID: PMC2877103.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    42. PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells. BMC Cancer. 2009 Nov 25; 9:411. Crosswell HE, Dasgupta A, Alvarado CS, Watt T, Christensen JG, De P, Durden DL, Findley HW. PMID: 19939254; PMCID: PMC2790467.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    43. In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells. Cancer Chemother Pharmacol. 2010 Mar; 65(4):697-706. Ozbay T, Durden DL, Liu T, O'Regan RM, Nahta R. PMID: 19636556; PMCID: PMC2808522.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    44. Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell. 2009 May 05; 15(5):363-75. Gu L, Zhu N, Zhang H, Durden DL, Feng Y, Zhou M. PMID: 19411066; PMCID: PMC2696306.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    45. Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. Cancer Res. 2009 Mar 15; 69(6):2540-9. Rong Y, Belozerov VE, Tucker-Burden C, Chen G, Durden DL, Olson JJ, Van Meir EG, Mackman N, Brat DJ. PMID: 19276385; PMCID: PMC2759716.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    46. Expression of RAC2 in endothelial cells is required for the postnatal neovascular response. Exp Cell Res. 2009 Jan 15; 315(2):248-63. De P, Peng Q, Traktuev DO, Traktuevc DO, Li W, Yoder MC, March KL, Durden DL. PMID: 19123268; PMCID: PMC2767303.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    47. PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis. Curr Pharm Des. 2009; 15(4):380-8. Castellino RC, Muh CR, Durden DL. PMID: 19199965.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res. 2008 Mar 15; 68(6):1862-71. Dey N, Crosswell HE, De P, Parsons R, Peng Q, Su JD, Durden DL. PMID: 18339867.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    49. A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res. 2008 Jan 01; 68(1):206-15. Garlich JR, De P, Dey N, Su JD, Peng X, Miller A, Murali R, Lu Y, Mills GB, Kundra V, Shu HK, Peng Q, Durden DL. PMID: 18172313.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    50. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol. 2007 Dec 15; 179(12):8322-31. Li Y, Yan J, De P, Chang HC, Yamauchi A, Christopherson KW, Paranavitana NC, Peng X, Kim C, Munugalavadla V, Munugulavadla V, Kapur R, Chen H, Shou W, Stone JC, Kaplan MH, Dinauer MC, Durden DL, Quilliam LA. PMID: 18056377; PMCID: PMC2722108.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    51. Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors. Nat Clin Pract Neurol. 2007 Dec; 3(12):682-93. Castellino RC, Durden DL. PMID: 18046441.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    52. CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation. Mol Cell Biol. 2007 Jun; 27(11):4179-97. Dey N, De PK, Wang M, Zhang H, Dobrota EA, Robertson KA, Durden DL. PMID: 17325034; PMCID: PMC1900023.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    53. A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth. Oncogene. 2007 Jun 07; 26(27):3930-40. Denning G, Jean-Joseph B, Prince C, Durden DL, Vogt PK. PMID: 17213812.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    54. Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. J Biol Chem. 2006 Oct 20; 281(42):31222-33. Reinert RB, Oberle LM, Wek SA, Bunpo P, Wang XP, Mileva I, Goodwin LO, Aldrich CJ, Durden DL, McNurlan MA, Wek RC, Anthony TG. PMID: 16931516.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    55. Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms. Cancer Res. 2006 Jul 15; 66(14):7067-74. Rong Y, Hu F, Huang R, Mackman N, Horowitz JM, Jensen RL, Durden DL, Van Meir EG, Brat DJ. PMID: 16849552; PMCID: PMC2610484.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    56. 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol. 2006 Jun; 65(6):529-39. Rong Y, Durden DL, Van Meir EG, Brat DJ. PMID: 16783163.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimals
    57. CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity. Exp Cell Res. 2005 Jul 01; 307(1):1-14. Dey N, Howell BW, De PK, Durden DL. PMID: 15890337.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    58. PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res. 2005 Feb 15; 65(4):1406-13. Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG, Brat DJ. PMID: 15735028.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    59. Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. J Biol Chem. 2005 Jan 14; 280(2):1543-51. Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML, Geahlen RL. PMID: 15536084.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
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