Herve Tiriac

Title(s)Assistant Researcher, Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patient-Derived 3D Cell Models as New Approach Methodologies: Applications, Advances, and Challenges for Increased-Throughput Assays. SLAS Discov. 2026 Sep 18; 100339. Courelli A, MacDonald M, Tiriac H. PMID: 42759888.
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    2. The Times They Are A-Changin': Pancreatic Cancer Surgery in the RAS Inhibitor Era. Ann Surg Oncol. 2026 Sep 01. Tiriac H, Lowy AM. PMID: 42681165.
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    3. Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis. Cell Stem Cell. 2026 Aug 06; 33(8):1270-1288.e7. Osorio-Vasquez V, Zhu J, Lumibao JC, Lande K, Peck KL, Stamp MK, Okhovat SR, Song H, Ogawa S, Kubota CS, Pantazopoulou V, Curtis K, Kuo K, Dai Y, Rock A, Bottomley CR, Thomas EJ, Hsu J, Herrera Morales A, Fowler A, McGriff T, Evensen KG, Williams AE, Larsen S, Abdulla M, Greer P, Gibson J, Downes M, Evans RM, Lowy AM, Whitcomb DC, Zou J, Molinolo A, Oh TG, White RR, Bellin M, Tiriac H, Engle DD. PMID: 42379165; PMCID: PMC13477807.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery. Proc Natl Acad Sci U S A. 2026 Jun 30; 123(26):e2536040123. Liang G, Nguyen HV, Zhu J, Tiriac H, Zafar H, Cao DY, Estepa G, Nelson DC, Dai Y, Oh TG, Liddle C, Yu RT, Hunter T, Engle D, Shaw R, Lowy AM, Fan W, Truitt ML, Atkins AR, Johnson JA, Downes M, Evans RM. PMID: 42348617; PMCID: PMC13320719.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma. bioRxiv. 2026 May 26. Hsu J, Song H, Ogawa S, Kubota CS, Peck KL, Jacobs E, Garcia-Rivera L, Zhu J, Sui Y, Jung W, Dai Y, Lumibao J, Bottomley CR, Curtis K, Bau M, Ku E, Kuo K, Morales AH, Stamp M, Rock A, Okhovat SR, Hunter T, Downes M, Evans R, Zou J, Oh TG, Zheng Y, Lowy AM, Tiriac H, Kaech SM, Engle DD. PMID: 42244695; PMCID: PMC13232252.
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    6. Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment. bioRxiv. 2026 May 05. Trimble AS, Kubota CS, Zhao E, Ruchhoeft ML, Weitz JR, Jung W, Peck KL, Ogawa S, Ashley EL, Tiriac H, Oh TG, Lowy AM, Engle DD, Metallo CM. PMID: 42039671; PMCID: PMC13104812.
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    7. Altered PI3K and ERK/MAPK Signaling in KRASG12R-Driven Pancreatic Cancer Presents Opportunities for Precision Therapy. Cancer Res. 2026 Apr 15; 86(8):1817-1819. Tiriac H, Engle DD. PMID: 41982125.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasation. bioRxiv. 2026 Apr 10. Ogawa S, Song H, Hsu J, Pantazopoulou V, Osorio-Vasquez V, Kubota CS, Tremblay JR, Bottomley CR, Lande K, Zhu J, Peck KL, Wang Y, Curtis K, Keightley S, Tomita R, Zou J, Downes M, Evans RM, Lowy AM, Tiriac H, Engle DD. PMID: 41993312; PMCID: PMC13082005.
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    9. Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug. Proc Natl Acad Sci U S A. 2026 Jan 27; 123(4):e2511733123. Antonucci L, Watari K, Feng Y, Qi J, Zhu M, Wang T, Ng I, Vucic EA, Riahi I, Huang L, Hosseini M, Mose E, French R, Weitz J, Bar-Sagi D, Dawson DW, Sun B, Tiriac H, Xu J, Xu S, Lowy AM, Karin M. PMID: 41564125; PMCID: PMC12849708.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics. bioRxiv. 2025 Nov 14. Osorio-Vasquez V, Zhu J, Lumibao JC, Lande K, Peck KL, Stamp MK, Okhovat SR, Song H, Ogawa S, Kubota C, Pantazopoulou V, Dai Y, Rock A, Bottomley C, Thomas E, Hsu J, Morales AH, Fowler A, McGriff T, Evensen KG, Larsen S, Abdulla M, Greer P, Gibson J, Downes M, Evans R, Lowy AM, Whitcomb DC, Zou J, Molinolo A, Oh TG, White R, Bellin M, Tiriac H, Engle DD. PMID: 41279927; PMCID: PMC12633304.
      View in: PubMed   Mentions: 1  
    11. Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer. bioRxiv. 2025 Sep 20. Beutel AK, Calderon S, Nghiem E, Gulay K, Santana LPS, Zimmer E, Singh R, Anaraki C, Yousefian N, Allgöwer C, Tong G, Geller C, Chao A, Juarez D, Seufferlein T, Muir A, Jang C, Edinger AL, Seldin M, Martinez TF, Kleger A, Chang DK, Tiriac H, Valerin JB, Fruman DA, Halbrook CJ. PMID: 41000736; PMCID: PMC12458164.
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    12. Experimental models of pancreas cancer: what has been the impact for precision medicine? J Clin Invest. 2025 08 15; 135(16). Pantazopoulou V, Kubota CS, Ogawa S, Gulay KCM, Lin X, Song H, Weitz JR, Tiriac H, Lowy AM, Engle DD. PMID: 40829173; PMCID: PMC12352895.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    13. ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC. Nat Chem Biol. 2026 02; 22(2):260-273. Tran NL, Jiang J, Ma M, Gadbois GE, Gulay KCM, Verano AL, Schiavon CR, Rebollo E, Zhou H, Huang CT, Murad R, Scott DA, Manor U, Bang AG, Tiriac H, Lowy AM, Wang ES, Ferguson FM. PMID: 40789946; PMCID: PMC13576644.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer. bioRxiv. 2025 Jun 05. Dufresne S, Kuna RS, Wong K, Komarla A, Rock A, Rosada-Encarnación J, Shen C, Mondal P, Parham LR, Izidro Layng F, Peck KL, Fowler A, Lowy AM, Engle D, Tiriac H, Shaw R, Cosford N, Metallo C, Towers C. PMID: 40501952; PMCID: PMC12154929.
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    15. Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer. Nature. 2025 06; 642(8066):212-221. Pei G, Min J, Rajapakshe KI, Branchi V, Liu Y, Selvanesan BC, Thege F, Sadeghian D, Zhang D, Cho KS, Chu Y, Dai E, Han G, Li M, Yee C, Takahashi K, Garg B, Tiriac H, Bernard V, Semaan A, Grem JL, Caffrey TC, Burks JK, Lowy AM, Aguirre AJ, Grandgenett PM, Hollingsworth MA, Guerrero PA, Wang L, Maitra A. PMID: 40269162; PMCID: PMC13242257.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    16. Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma. J Pharmacol Exp Ther. 2025 May; 392(5):103573. Salmerón C, Tomás Bort E, Sriram K, Javadi-Paydar M, Smitham JE, Pham K, Grose RP, McCormick PJ, DiNardo A, Weitz J, Tiriac H, Lowy AM, Insel PA. PMID: 40288207.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. MICAL2 Promotes Pancreatic Cancer Growth and Metastasis. Cancer Res. 2025 03 14; 85(6):1049-1063. Garg B, Khan S, Courelli AS, Panneerpandian P, Sheik Pran Babu D, Mose ES, Gulay KCM, Sharma S, Sood D, Wenzel AT, Martsinkovskiy A, Rajbhandari N, Patel J, Jaquish D, Esparza E, Jaque K, Aggarwal N, Lambies G, D'Ippolito A, Austgen K, Johnston B, Orlando DA, Jang GH, Gallinger S, Goodfellow E, Brodt P, Commisso C, Tamayo P, Mesirov JP, Tiriac H, Lowy AM. PMID: 39745352; PMCID: PMC11907191.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Cyclin-Dependent Kinase 4/6 Inhibition as a Novel Therapy for Peritoneal Mucinous Carcinomatosis With GNAS Mutations. J Clin Oncol. 2025 02 20; 43(6):705-715. Weitz J, Nishizaki D, Liau J, Patel J, Ng I, Sun S, Ramms D, Zou J, Wishart B, Rull J, Baumgartner J, Kelly K, White R, Veerapong J, Hosseini M, Patel H, Botta G, Gutkind JS, Tiriac H, Kato S, Lowy AM. PMID: 39413348; PMCID: PMC11829827.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis. bioRxiv. 2024 Jun 30. Garg B, Khan S, Babu DS, Mose E, Gulay K, Sharma S, Sood D, Wenzel AT, Martsinkovskiy A, Patel J, Jaquish D, Lambies G, D'Ippolito A, Austgen K, Johnston B, Orlando D, Jang GH, Gallinger S, Goodfellow E, Brodt P, Commisso C, Tamayo P, Mesirov JP, Tiriac H, Lowy AM. PMID: 38979336; PMCID: PMC11230455.
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    20. ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC. bioRxiv. 2024 May 21. Tran NL, Jiang J, Ma M, Gadbois GE, Gulay KCM, Verano A, Zhou H, Huang CT, Scott DA, Bang AG, Tiriac H, Lowy AM, Wang ES, Ferguson FM. PMID: 38826238; PMCID: PMC11142081.
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    21. The novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer. Sci Rep. 2024 03 16; 14(1):6373. Hagi T, Vangveravong S, Takchi R, Gong Q, Goedegebuure SP, Tiriac H, Van Tine BA, Powell MA, Hawkins WG, Spitzer D. PMID: 38493257; PMCID: PMC10944456.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    22. The effect of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids. JCI Insight. 2024 01 09; 9(1). Lumibao JC, Okhovat SR, Peck KL, Lin X, Lande K, Yomtoubian S, Ng I, Tiriac H, Lowy AM, Zou J, Engle DD. PMID: 38051586; PMCID: PMC10906458.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    23. Engrailed-1 Promotes Pancreatic Cancer Metastasis. Adv Sci (Weinh). 2024 02; 11(6):e2308537. Xu J, Roe JS, Lee E, Tonelli C, Ji KY, Younis OW, Somervile TDD, Yao M, Milazzo JP, Tiriac H, Kolarzyk AM, Lee E, Grem JL, Lazenby AJ, Grunkemeyer JA, Hollingsworth MA, Grandgenett PM, Borowsky AD, Park Y, Vakoc CR, Tuveson DA, Hwang CI. PMID: 38110836; PMCID: PMC10853725.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    24. Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. Nat Commun. 2023 12 06; 14(1):7791. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 38057326; PMCID: PMC10700526.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma. Nat Cancer. 2024 01; 5(1):100-113. Recouvreux MV, Grenier SF, Zhang Y, Esparza E, Lambies G, Galapate CM, Maganti S, Duong-Polk K, Bhullar D, Naeem R, Scott DA, Lowy AM, Tiriac H, Commisso C. PMID: 37814011; PMCID: PMC10956382.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    26. Pancreatic ductal adenocarcinoma induces neural injury that promotes a transcriptomic and functional repair signature by peripheral neuroglia. Oncogene. 2023 08; 42(34):2536-2546. Weitz J, Garg B, Martsinkovskiy A, Patel S, Tiriac H, Lowy AM. PMID: 37433986; PMCID: PMC10880465.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. Pancreatic Ductal Adenocarcinoma Induces Neural Injury that Promotes a Transcriptomic and Functional Repair Signature by Peripheral Neuroglia. Res Sq. 2023 Mar 28. Weitz J, Garg B, Tiriac H, Martsinkovskiy A, Patel S, Lowy A. PMID: 37034696; PMCID: PMC10081383.
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    28. Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model. J Immunother Cancer. 2023 01; 11(1). Shankara Narayanan JS, Hayashi T, Erdem S, McArdle S, Tiriac H, Ray P, Pu M, Mikulski Z, Miller A, Messer K, Carson D, Schoenberger S, White RR. PMID: 36634919; PMCID: PMC9843215.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    29. Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens. J Vis Exp. 2022 12 09; (190). Weitz J, Montecillo Gulay KC, Hurtado de Mendoza T, Tiriac H, Baumgartner J, Kelly K, Veerapong J, Lowy AM. PMID: 36571414; PMCID: PMC10880464.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    30. An Ex Vivo Organotypic Culture Platform for Functional Interrogation of Human Appendiceal Cancer Reveals a Prominent and Heterogenous Immunological Landscape. Clin Cancer Res. 2022 11 01; 28(21):4793-4806. Weitz J, Hurtado de Mendoza T, Tiriac H, Lee J, Sun S, Garg B, Patel J, Li K, Baumgartner J, Kelly KJ, Veerapong J, Hosseini M, Chen Y, Lowy AM. PMID: 36067351.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    31. Patient-Derived Sarcoma Organoids Offer a Novel Platform for Personalized Precision Medicine. Ann Surg Oncol. 2022 11; 29(12):7239-7241. Sanchez-Fdez A, Sharma AK, Tiriac H, Sicklick JK. PMID: 35831519; PMCID: PMC10173699.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    32. Using Organotypic Tissue Slices to Investigate the Microenvironment of Pancreatic Cancer: Pharmacotyping and Beyond. Cancers (Basel). 2021 Oct 05; 13(19). Weitz JR, Tiriac H, Hurtado de Mendoza T, Wascher A, Lowy AM. PMID: 34638476; PMCID: PMC8507648.
      View in: PubMed   Mentions: 12  
    33. Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers. Nat Commun. 2020 10 21; 11(1):5332. Bradley SD, Talukder AH, Lai I, Davis R, Alvarez H, Tiriac H, Zhang M, Chiu Y, Melendez B, Jackson KR, Katailiha A, Sonnemann HM, Li F, Kang Y, Qiao N, Pan BF, Lorenzi PL, Hurd M, Mittendorf EA, Peterson CB, Javle M, Bristow C, Kim M, Tuveson DA, Hawke D, Kopetz S, Wolff RA, Hwu P, Maitra A, Roszik J, Yee C, Lizée G. PMID: 33087697; PMCID: PMC7577998.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models. J Vis Exp. 2020 01 14; (155). Tiriac H, French R, Lowy AM. PMID: 32009658.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Organoid models for translational pancreatic cancer research. Curr Opin Genet Dev. 2019 02; 54:7-11. Tiriac H, Plenker D, Baker LA, Tuveson DA. PMID: 30844513; PMCID: PMC6722026.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    36. Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment. Gastrointest Endosc. 2018 Jun; 87(6):1474-1480. Tiriac H, Bucobo JC, Tzimas D, Grewel S, Lacomb JF, Rowehl LM, Nagula S, Wu M, Kim J, Sasson A, Vignesh S, Martello L, Munoz-Sagastibelza M, Somma J, Tuveson DA, Li E, Buscaglia JM. PMID: 29325707; PMCID: PMC6143289.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    37. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell. 2016 Aug 11; 166(4):963-976. Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. PMID: 27477511; PMCID: PMC5234705.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimalsCells
    38. Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Oncotarget. 2016 Jun 07; 7(23):33529-41. Ohman KA, Hashim YM, Vangveravong S, Nywening TM, Cullinan DR, Goedegebuure SP, Liu J, Van Tine BA, Tiriac H, Tuveson DA, DeNardo DG, Spitzer D, Mach RH, Hawkins WG. PMID: 27244881; PMCID: PMC5085100.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    39. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. PMID: 25259922; PMCID: PMC4177038.
      View in: PubMed   Mentions: 643     Fields:    Translation:HumansAnimalsCells
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