Shiyin Yao

Title(s)	SRA 3, Cancer Center
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx. ACS Chem Biol. 2023 04 21; 18(4):982-993. Sako Y, Sato-Kaneko F, Shukla NM, Yao S, Belsuzarri MM, Chan M, Saito T, Lao FS, Kong H, Puffer M, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T. PMID: 37039433; PMCID: PMC10127211.

View in: PubMed Mentions: Fields:
Bio Biochemistry Bio Biology
Translation:Animals Cells PHPublic Health
A Dual Adjuvant System for Intranasal Boosting of Local and Systemic Immunity for Influenza Vaccination. Vaccines (Basel). 2022 Oct 11; 10(10). Sato-Kaneko F, Yao S, Lao FS, Sako Y, Jin J, Shukla NM, Cottam HB, Chan M, Belsuzarri MM, Carson DA, Hayashi T. PMID: 36298559; PMCID: PMC9611830.

View in: PubMed Mentions: 2
A Triple High Throughput Screening for Extracellular Vesicle Inducing Agents With Immunostimulatory Activity. Front Pharmacol. 2022; 13:869649. Shukla NM, Sato-Kaneko F, Yao S, Pu M, Chan M, Lao FS, Sako Y, Saito T, Messer K, Hayashi T, Cottam HB, Corr M, Carson DA. PMID: 35479316; PMCID: PMC9035538.

View in: PubMed Mentions: 2
Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. ACS Chem Biol. 2022 01 21; 17(1):217-229. Saito T, Shukla NM, Sato-Kaneko F, Sako Y, Hosoya T, Yao S, Lao FS, Messer K, Pu M, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34985883; PMCID: PMC8788586.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Animals Cells
Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Front Immunol. 2021; 12:701445. Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. PMID: 34650551; PMCID: PMC8505803.

View in: PubMed Mentions: 2 Fields:
All Allergy and Immunology
Translation:Animals Cells
Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Sato-Kaneko F, Yao S, Lao FS, Nan J, Shpigelman J, Cheng A, Saito T, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Molina AJ, Corr M, Hayashi T, Carson DA. PMID: 34078669; PMCID: PMC8201894.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Humans Animals Cells
Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation. Bioorg Med Chem. 2021 08 01; 43:116242. Shukla NM, Chan M, Lao FS, Chu PJ, Belsuzarri M, Yao S, Nan J, Sato-Kaneko F, Saito T, Hayashi T, Corr M, Carson DA, Cottam HB. PMID: 34274759; PMCID: PMC8992012.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release. Front Pharmacol. 2021; 12:668609. Shpigelman J, Lao FS, Yao S, Li C, Saito T, Sato-Kaneko F, Nolan JP, Shukla NM, Pu M, Messer K, Cottam HB, Carson DA, Corr M, Hayashi T. PMID: 33935791; PMCID: PMC8085554.

View in: PubMed Mentions: 8
Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Front Pharmacol. 2020; 11:607713. Hosoya T, Shukla NM, Fujita Y, Yao S, Lao FS, Baba H, Yasuda S, Cottam HB, Carson DA, Hayashi T, Corr M. PMID: 33390996; PMCID: PMC7773657.

View in: PubMed Mentions: 1
A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity. Front Immunol. 2020; 11:1207. Sato-Kaneko F, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Chu PJ, Burkhart D, Schoener R, Matsutani T, Carson DA, Corr M, Hayashi T. PMID: 32636840; PMCID: PMC7318308.

View in: PubMed Mentions: 13 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Immunostimulatory TLR7 agonist-nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Adv Ther (Weinh). 2020 Jun; 3(6). Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Yao S, Blair SL, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC. PMID: 33644299; PMCID: PMC7904104.

View in: PubMed Mentions: 5
Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli. J Med Chem. 2019 11 14; 62(21):9521-9540. Chan M, Lao FS, Chu PJ, Shpigelman J, Yao S, Nan J, Sato-Kaneko F, Li V, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 31603681; PMCID: PMC8992017.

View in: PubMed Mentions: 4 Fields:
Che Chemistry
Translation:Humans Cells
Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. Biomed Res Int. 2018; 2018:8091283. Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T. PMID: 30406141; PMCID: PMC6199861.

View in: PubMed Mentions: 4 Fields:
Bio Biotechnology Med Medicine (General)
Translation:Humans Animals Cells
Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6836-E6844. Hosoya T, Sato-Kaneko F, Ahmadi A, Yao S, Lao F, Kitaura K, Matsutani T, Carson DA, Hayashi T. PMID: 29967183; PMCID: PMC6055176.

View in: PubMed Mentions: 15 Fields:
Sci Science
Translation:Animals Cells
Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018 10; 23(9):960-973. Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M. PMID: 29751735; PMCID: PMC6697428.

View in: PubMed Mentions: 7 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands. J Med Chem. 2017 11 22; 60(22):9142-9161. Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M. PMID: 29049886; PMCID: PMC5940354.

View in: PubMed Mentions: 10 Fields:
Che Chemistry
Translation:Humans Animals
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 09 21; 2(18). Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. PMID: 28931759; PMCID: PMC5621908.

View in: PubMed Mentions: 136 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity. ACS Comb Sci. 2017 08 14; 19(8):533-543. Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM. PMID: 28657707; PMCID: PMC5841913.

View in: PubMed Mentions: 13 Fields:
Che Chemistry
Translation:Humans Animals Cells PHPublic Health
Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19; 26(8):1713-23. Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam HB, Carson DA. PMID: 26193334.

View in: PubMed Mentions: 17 Fields:
Bio Biochemistry
Translation:Humans Animals Cells PHPublic Health
Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes. PLoS One. 2015; 10(6):e0129867. Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson DA, Corr M. PMID: 26076454; PMCID: PMC4468074.

View in: PubMed Mentions: 14 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. Bioorg Med Chem Lett. 2014 Nov 01; 24(21):4931-8. Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 25288184; PMCID: PMC4250372.

View in: PubMed Mentions: 10 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014 Aug; 350(2):330-40. Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson DA. PMID: 24893985; PMCID: PMC4109491.

View in: PubMed Mentions: 7 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Animals Cells
The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1409-14. Fernandez A, Huggins IJ, Perna L, Brafman D, Lu D, Yao S, Gaasterland T, Carson DA, Willert K. PMID: 24474766; PMCID: PMC3910637.

View in: PubMed Mentions: 53 Fields:
Sci Science
Translation:Humans Animals Cells
Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand. J Innate Immun. 2014; 6(3):315-24. Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T. PMID: 24192551; PMCID: PMC3972367.

View in: PubMed Mentions: 12 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem. 2013 Jun 13; 56(11):4206-23. Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB. PMID: 23656327; PMCID: PMC3722616.

View in: PubMed Mentions: 41 Fields:
Che Chemistry
Translation:Humans Animals Cells
Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One. 2012; 7(9):e45860. Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson DA, Corr M. PMID: 23029281; PMCID: PMC3461028.

View in: PubMed Mentions: 9 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand. Mediators Inflamm. 2012; 2012:262394. Hayashi T, Yao S, Crain B, Chan M, Cottam HB, Lao F, Carson DA, Corr M. PMID: 22619481; PMCID: PMC3348532.

View in: PubMed Mentions: 6 Fields:
Bio Biochemistry Pat Pathology
Translation:Animals Cells
Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem. 2011 Mar 16; 22(3):445-54. Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam HB, Carson DA. PMID: 21338093; PMCID: PMC3063487.

View in: PubMed Mentions: 18 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2. Melanoma Res. 2011 Feb; 21(1):66-75. Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam HB, Tawatao RI, Corr M, Carson DA, Daniels GA. PMID: 21030882; PMCID: PMC3057341.

View in: PubMed Mentions: 14 Fields:
Neo Neoplasms
Translation:Animals Cells
Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7479-84. Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB, Carson DA. PMID: 20368435; PMCID: PMC2867719.

View in: PubMed Mentions: 59 Fields:
Sci Science
Translation:Humans Cells
Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14; 4(12):e8294. Lu D, Liu JX, Endo T, Zhou H, Yao S, Willert K, Schmidt-Wolf IG, Kipps TJ, Carson DA. PMID: 20011538; PMCID: PMC2789382.

View in: PubMed Mentions: 43 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):606-9. Jin G, Lu D, Yao S, Wu CC, Liu JX, Carson DA, Cottam HB. PMID: 19121941; PMCID: PMC5940355.

View in: PubMed Mentions: 14 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Localization of the naturally occurring plasmid ColE1 at the cell pole. J Bacteriol. 2007 Mar; 189(5):1946-53. Yao S, Helinski DR, Toukdarian A. PMID: 17158664; PMCID: PMC1855736.

View in: PubMed Mentions: 23 Fields:
Bac Bacteriology
Translation:Cells
Inhibition of protein and RNA synthesis in Escherichia coli results in declustering of plasmid RK2. Plasmid. 2006 Sep; 56(2):124-32. Yao S, Toukdarian A, Helinski DR. PMID: 16774785.

View in: PubMed Mentions: 2 Fields:
Gen Genetics
Translation:Cells
Functional analysis of two putative chromosomal replication origins from Pseudomonas aeruginosa. Plasmid. 2006 May; 55(3):194-200. Jiang Y, Yao S, Helinski D, Toukdarian A. PMID: 16376988.

View in: PubMed Mentions: 5 Fields:
Gen Genetics
Translation:Cells
Gyrase inhibitors and thymine starvation disrupt the normal pattern of plasmid RK2 localization in Escherichia coli. J Bacteriol. 2005 May; 187(10):3538-47. Johnson EP, Yao S, Helinski DR. PMID: 15866942; PMCID: PMC1112003.

View in: PubMed Mentions: 1 Fields:
Bac Bacteriology
Translation:Cells