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Wilbur Lew

Title(s)Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    MECHANICAL INTERACTION OF ISCHEMIC AND NONISCHEMIC AREAS
    NIH K08HL001731Jul 1, 1986 - Jun 30, 1991
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Exercise: commitment to a young heart. J Am Coll Cardiol. 2014 Sep 23; 64(12):1267-9. PMID: 25236520.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Myocardial fibrosis induced by exposure to subclinical lipopolysaccharide is associated with decreased miR-29c and enhanced NOX2 expression in mice. PLoS One. 2014; 9(9):e107556. Lew WY, Bayna E, Dalle Molle E, Contu R, Condorelli G, Tang T. PMID: 25233448.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    3. Highlights of the year in JACC 2013. J Am Coll Cardiol. 2014 Feb 18; 63(6):570-602. PMID: 24524815.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Recurrent exposure to subclinical lipopolysaccharide increases mortality and induces cardiac fibrosis in mice. PLoS One. 2013; 8(4):e61057. PMID: 23585870.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    5. Diabetes and coronary disease: a need for new therapies for an expanding disease burden. J Am Coll Cardiol. 2013 May 21; 61(20):2046-7. PMID: 23500323.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Highlights of the year in JACC 2012. J Am Coll Cardiol. 2013 Jan 22; 61(3):357-85. PMID: 23328613.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. The divergence between clinical guidelines and practice. J Am Coll Cardiol. 2013 Jan 08; 61(1):41-3. PMID: 23137937.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Highlights of the Year in JACC 2011. J Am Coll Cardiol. 2012 Jan 31; 59(5):503-37. PMID: 22281255.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Highlights of the year in JACC 2010. J Am Coll Cardiol. 2011 Jan 25; 57(4):480-514. DeMaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S. PMID: 21251590.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart. Biochem Biophys Res Commun. 2011 Feb 18; 405(3):349-55. PMID: 21195051.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Protein quality control in heart disease: using established drugs to target novel mechanisms. J Am Coll Cardiol. 2010 Oct 19; 56(17):1427-9. Villarreal F, Lew WY. PMID: 20947001.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Highlights of the Year in JACC 2009. J Am Coll Cardiol. 2010 Jan 26; 55(4):380-407. DeMaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S. PMID: 20117446.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Diastolic release of calcium from the sarcoplasmic reticulum: a potential target for treating triggered arrhythmias and heart failure. J Am Coll Cardiol. 2009 May 26; 53(21):2006-8. Shannon TR, Lew WY. PMID: 19460615.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Highlights of the Year in JACC 2008. J Am Coll Cardiol. 2009 Jan 27; 53(4):373-98. DeMaria AN, Ben-Yehuda O, Bax JJ, Feld GK, Greenberg BH, Lew WY, Lima JA, Maisel AS, Narayan SM, Sahn DJ, Tsimikas S. PMID: 19161890.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Highlights of the year in JACC 2007. J Am Coll Cardiol. 2008 Jan 29; 51(4):490-512. DeMaria AN, Bax JJ, Ben-Yehuda O, Clopton P, Feld GK, Ginsburg GS, Greenberg BH, Knoke JD, Lew WY, Lima JA, Maisel AS, Narayan SM, Narula J, Sahn DJ, Tsimikas S. PMID: 18222362.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. A cool heart protected from infarction: clinical translation of breathing chilled liquids. J Am Coll Cardiol. 2007 Feb 06; 49(5):606-7. Lew WY. PMID: 17276186.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. Highlights of the Year in JACC 2006. J Am Coll Cardiol. 2007 Jan 30; 49(4):509-27. DeMaria AN, Ben-Yehuda O, Feld GK, Ginsburg GS, Greenberg BH, Lew WY, Lima JA, Maisel AS, Narula J, Sahn DJ, Tsimikas S. PMID: 17258099.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Lipopolysaccharide activates calcineurin in ventricular myocytes. J Am Coll Cardiol. 2007 Jan 30; 49(4):491-9. Suzuki J, Bayna E, Li HL, Molle ED, Lew WY. PMID: 17258096.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation. 2006 Aug 01; 114(5):388-96. Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, Saito M, Lew WY, Clopton P, Hammond HK. PMID: 16864723.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    20. Highlights of the Year in JACC 2005. J Am Coll Cardiol. 2006 Jan 03; 47(1):184-202. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Ginsberg J, Greenberg BH, Lew WY, Sahn D, Tsimikas S. PMID: 16386685.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    21. Highlights of the year in JACC 2004. J Am Coll Cardiol. 2005 Jan 04; 45(1):137-53. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Narula J, Sahn D, Tsimikas S. PMID: 15629388.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    22. Mobilizing cells to the injured myocardium: a novel rescue strategy or an unwelcome intrusion? J Am Coll Cardiol. 2004 Oct 06; 44(7):1521-2. Lew WY. PMID: 15464337.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. Highlights of the year in JACC 2003. J Am Coll Cardiol. 2003 Dec 17; 42(12):2156-66. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Tsimikas S. PMID: 15560019.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Endotoxin attacks the cardiovascular system: black death at the tollgate. J Am Coll Cardiol. 2003 Nov 05; 42(9):1663-5. Lew WY. PMID: 14607456.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats. J Am Coll Cardiol. 2003 Feb 05; 41(3):482-8. Suzuki J, Bayna E, Dalle Molle E, Lew WY. PMID: 12575980.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. Lipopolysaccharide induces apoptosis in adult rat ventricular myocytes via cardiac AT(1) receptors. . 2002 Aug; 283(2):H461-7. Li HL, Suzuki J, Bayna E, Zhang FM, Dalle Molle E, Clark A, Engler RL, Lew WY. PMID: 12124189.
      View in: PubMed   Mentions:
    27. Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility. Circulation. 1999 Aug 31; 100(9):974-80. He H, Meyer M, Martin JL, McDonough PM, Ho P, Lou X, Lew WY, Hilal-Dandan R, Dillmann WH. PMID: 10468529.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    28. Angiotensin II exacerbates lipopolysaccharide-induced contractile depression in rabbit cardiac myocytes. Am J Physiol. 1999 05; 276(5):H1442-9. Yasuda S, Lew WY. PMID: 10330226.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    29. Phospholamban-to-SERCA2 ratio controls the force-frequency relationship. Am J Physiol. 1999 03; 276(3):H779-85. Meyer M, Bluhm WF, He H, Post SR, Giordano FJ, Lew WY, Dillmann WH. PMID: 10070059.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    30. Mechanisms of length history-dependent tension in an ionic model of the cardiac myocyte. Am J Physiol. 1998 03; 274(3):H1032-40. Bluhm WF, Lew WY, Garfinkel A, McCulloch AD. PMID: 9530218.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Cellular mechanisms for the slow phase of the Frank-Starling response. J Electrocardiol. 1998; 31 Suppl:13-22. Bluhm WF, Sung D, Lew WY, Garfinkel A, McCulloch AD. PMID: 9988000.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. Lipopolysaccharide depresses cardiac contractility and beta-adrenergic contractile response by decreasing myofilament response to Ca2+ in cardiac myocytes. Circ Res. 1997 Dec; 81(6):1011-20. Yasuda S, Lew WY. PMID: 9400382.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    33. Endothelin-1 ameliorates contractile depression by lipopolysaccharide in cardiac myocytes. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1403-7. Yasuda S, Lew WY. PMID: 9321831.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Depyrogenation of digestive enzymes reduces lipopolysaccharide tolerance in isolated cardiac myocytes. J Mol Cell Cardiol. 1997 Jul; 29(7):1985-90. Lew WY, Lee M, Yasuda S, Bayna E. PMID: 9236152.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    35. Lipopolysaccharide induces cell shrinkage in rabbit ventricular cardiac myocytes. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2989-93. Lew WY, Ryan J, Yasuda S. PMID: 9227578.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    36. Endotoxin-induced cardiac depression is associated with decreased cardiac dihydropyridine receptors in rabbits. J Mol Cell Cardiol. 1996 Jun; 28(6):1367-71. Lew WY, Yasuda S, Yuan T, Hammond HK. PMID: 8782078.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    37. Serum tumor necrosis factor-alpha does not mediate endotoxin-induced myocardial depression in rabbits. Am J Physiol. 1996 Feb; 270(2 Pt 2):H485-91. Nishikawa Y, Mathison J, Lew WY. PMID: 8779822.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    38. Active force in rabbit ventricular myocytes. J Biomech. 1995 Sep; 28(9):1119-22. Bluhm WF, McCulloch AD, Lew WY. PMID: 7559682.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. Endotoxin-induced left ventricular depression is blocked by nitrogen mustard or dimethylthiourea in rabbits. Am J Physiol. 1995 Sep; 269(3 Pt 2):H1098-105. Nishikawa Y, Lew WY. PMID: 7573507.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    40. Sarcoplasmic reticulum in cardiac length-dependent activation in rabbits. Am J Physiol. 1995 Sep; 269(3 Pt 2):H965-72. Bluhm WF, Lew WY. PMID: 7573541.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    41. Asynchrony and ryanodine modulate load-dependent relaxation in the canine left ventricle. Am J Physiol. 1995 Jan; 268(1 Pt 2):H17-24. Lew WY. PMID: 7840261.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    42. Cardiac myocyte function and left ventricular strains after brief ischemia and reperfusion in rabbits. Circulation. 1994 Oct; 90(4):1942-50. Lew WY, Nishikawa Y, Su H. PMID: 7923683.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    43. Mechanisms of volume-induced increase in left ventricular contractility. Am J Physiol. 1993 Nov; 265(5 Pt 2):H1778-86. Lew WY. PMID: 8238591.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    44. Temporal sequence of endotoxin-induced systolic and diastolic myocardial depression in rabbits. Am J Physiol. 1993 Sep; 265(3 Pt 2):H810-9. Hung J, Lew WY. PMID: 8214114.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    45. Cellular mechanisms of endotoxin-induced myocardial depression in rabbits. Circ Res. 1993 Jul; 73(1):125-34. Hung J, Lew WY. PMID: 8508524.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    46. Production and characterization of monoclonal antibodies to Treponema pallidum. J Dermatol Sci. 1992 Jul; 4(1):26-32. Whang KK, Lee MG, Lew W, Lee JB. PMID: 1390455.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    47. Dihydropyridine receptors are primarily functional L-type calcium channels in rabbit ventricular myocytes. Circ Res. 1991 Oct; 69(4):1139-45. Lew WY, Hryshko LV, Bers DM. PMID: 1657438.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    48. Influence of systolic pressure profile on rate of left ventricular pressure fall. Am J Physiol. 1991 Sep; 261(3 Pt 2):H805-13. Gillebert TC, Lew WY. PMID: 1887926.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    49. Transmural myocardial deformation in the ischemic canine left ventricle. Circ Res. 1991 Feb; 68(2):368-81. Villarreal FJ, Lew WY, Waldman LK, Covell JW. PMID: 1991344.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    50. Finite strains in anterior and posterior wall of canine left ventricle. Am J Physiol. 1990 Nov; 259(5 Pt 2):H1409-18. Villarreal FJ, Lew WY. PMID: 2240241.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    51. Independent influence of left atrial pressure on regional peak lengthening rates. Am J Physiol. 1990 Aug; 259(2 Pt 2):H480-7. Hoit BD, LeWinter M, Lew WY. PMID: 2386222.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    52. Nonuniformity and volume loading independently influence isovolumic relaxation rates. Am J Physiol. 1989 Dec; 257(6 Pt 2):H1927-35. Gillebert TC, Lew WY. PMID: 2603977.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    53. Evaluation of left ventricular diastolic function. Circulation. 1989 Jun; 79(6):1393-7. Lew WY. PMID: 2498007.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    54. Influence of nonuniformity on rate of left ventricular pressure fall in the dog. Am J Physiol. 1989 Jan; 256(1 Pt 2):H222-32. Lew WY, Rasmussen CM. PMID: 2912186.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    55. Regional variation in pericardial contact pressure in the canine ventricle. Am J Physiol. 1988 Dec; 255(6 Pt 2):H1370-7. Hoit BD, Lew WY, LeWinter M. PMID: 3202201.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    56. Time-dependent increase in left ventricular contractility following acute volume loading in the dog. Circ Res. 1988 Sep; 63(3):635-47. Lew WY. PMID: 2457459.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    57. Functional consequences of acute anterior vs. posterior wall ischemia in canine left ventricles. Am J Physiol. 1988 Jun; 254(6 Pt 2):H1065-73. Hoit BD, Lew WY. PMID: 3381894.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    58. Technique for measuring regional two-dimensional finite strains in canine left ventricle. Circ Res. 1988 Apr; 62(4):711-21. Villarreal FJ, Waldman LK, Lew WY. PMID: 3349574.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    59. Decreased regional contractility in nonischemic myocardium during acute coronary artery occlusion in conscious pigs. Am J Cardiovasc Pathol. 1988; 1(3):379-87. Guth BD, White FC, Widmann T, Lew W, Bloor CM. PMID: 3207482.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    60. Risk of developing complete heart block during bedside pulmonary artery catheterization in patients with left bundle-branch block. Arch Intern Med. 1987 Nov; 147(11):2005-10. Morris D, Mulvihill D, Lew WY. PMID: 3675104.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    61. Influence of the pericardium on right and left ventricular filling in the dog. J Appl Physiol (1985). 1987 Sep; 63(3):1025-32. Assanelli D, Lew WY, Shabetai R, LeWinter MM. PMID: 3654452.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    62. Influence of ischemic zone size on nonischemic area function in the canine left ventricle. Am J Physiol. 1987 May; 252(5 Pt 2):H990-7. Lew WY. PMID: 3578547.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    63. In vivo mechanical behavior of canine pericardium. Am J Physiol. 1986 Aug; 251(2 Pt 2):H349-56. Mann D, Lew W, Ban-Hayashi E, Shabetai R, Waldman L, LeWinter MM. PMID: 3740289.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    64. Hysteresis of left ventricular end ejection pressure-dimension relations after acute pressure loading in the intact canine heart. Cardiovasc Res. 1986 Jul; 20(7):490-7. Way B, Victory J, LeWinter MM, Lew WY, Doyle R, Foëx P, Ryder WA, Jones LA. PMID: 3779745.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    65. Regional comparison of midwall segment and area shortening in the canine left ventricle. Circ Res. 1986 May; 58(5):678-91. Lew WY, LeWinter MM. PMID: 3708765.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    66. Cardiopulmonary effects of cuprophane-activated plasma in the swine. Kidney Int. 1986 Apr; 29(4):799-806. Cheung AK, LeWinter M, Chenoweth DE, Lew WY, Henderson LW. PMID: 3086612.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    67. Substance P, 5-hydroxytryptamine, and bradykinin stimulate abdominal visceral afferents. Am J Physiol. 1986 Mar; 250(3 Pt 2):R465-73. Lew WY, Longhurst JC. PMID: 2420215.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    68. Torsades de pointes and sudden death in a patient with a permanent pacemaker. Can J Cardiol. 1986 Mar-Apr; 2(2):86-7. Lew WY, Goldberger AL. PMID: 3635423.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. Mechanisms of improving regional and global ventricular function by preload alterations during acute ischemia in the canine left ventricle. Circulation. 1985 Nov; 72(5):1125-34. Lew WY, Ban-Hayashi E. PMID: 4042300.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    70. Mechanisms of augmented segment shortening in nonischemic areas during acute ischemia of the canine left ventricle. Circ Res. 1985 Mar; 56(3):351-8. Lew WY, Chen ZY, Guth B, Covell JW. PMID: 3971509.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    71. Regional circumferential lengthening patterns in canine left ventricle. Am J Physiol. 1983 Nov; 245(5 Pt 1):H741-8. Lew WY, LeWinter MM. PMID: 6638197.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    72. Hemodynamic and electrocardiographic effects in man of a new nonionic contrast agent (iohexol): advantages over standard ionic agents. Am J Cardiol. 1983 Apr; 51(7):1218-22. Mancini GB, Bloomquist JN, Bhargava V, Stein JB, Lew W, Slutsky RA, Shabetai R, Higgins CB. PMID: 6837464.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    73. The isovolumic index: a new noninvasive approach to the assessment of left ventricular function in man. Am J Cardiol. 1982 Dec; 50(6):1401-8. Mancini GB, Costello D, Bhargava V, Lew W, LeWinter M, Karliner JS. PMID: 7148720.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    74. Assessment of mitral valve E point-septal separation as an index of left ventricular performance in patients with acute and previous myocardial infarction. Am J Cardiol. 1978 May 01; 41(5):836-45. Lew W, Henning H, Schelbert H, Karliner JS. PMID: 645591.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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