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Wilbur Lew

Title(s)Professor In Residence, Medicine
SchoolHealth Sciences
Phone858-552-8585
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    MECHANICAL INTERACTION OF ISCHEMIC AND NONISCHEMIC AREAS
    NIH/NHLBI K08HL001731Jul 1, 1986 - Jun 30, 1991
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lew WY. Exercise: commitment to a young heart. J Am Coll Cardiol. 2014 Sep 23; 64(12):1267-9. PMID: 25236520.
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    2. Lew WY, Bayna E, Dalle Molle E, Contu R, Condorelli G, Tang T. Myocardial fibrosis induced by exposure to subclinical lipopolysaccharide is associated with decreased miR-29c and enhanced NOX2 expression in mice. PLoS One. 2014; 9(9):e107556. PMID: 25233448.
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    3. DeMaria AN, Adler ED, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall JL, Hlatky MA, Lew WY, Lima JA, Mahmud E, Maisel AS, Narayan SM, Nissen SE, Sahn DJ, Tsimikas S. Highlights of the year in JACC 2013. J Am Coll Cardiol. 2014 Feb 18; 63(6):570-602. PMID: 24524815.
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    4. Lew WY, Bayna E, Molle ED, Dalton ND, Lai NC, Bhargava V, Mendiola V, Clopton P, Tang T. Recurrent exposure to subclinical lipopolysaccharide increases mortality and induces cardiac fibrosis in mice. PLoS One. 2013; 8(4):e61057. PMID: 23585870.
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    5. Lew WY, DeMaria AN. Diabetes and coronary disease: a need for new therapies for an expanding disease burden. J Am Coll Cardiol. 2013 May 21; 61(20):2046-7. PMID: 23500323.
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    6. DeMaria AN, Bax JJ, Feld GK, Greenberg BH, Hall JL, Hlatky MA, Lew WY, Lima JA, Mahmud E, Maisel AS, Narayan SM, Nissen SE, Sahn DJ, Tsimikas S. Highlights of the year in JACC 2012. J Am Coll Cardiol. 2013 Jan 22; 61(3):357-85. PMID: 23328613.
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    7. Lew WY, DeMaria AN. The divergence between clinical guidelines and practice. J Am Coll Cardiol. 2013 Jan 08; 61(1):41-3. PMID: 23137937.
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    8. Demaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S. Highlights of the Year in JACC 2011. J Am Coll Cardiol. 2012 Jan 31; 59(5):503-37. PMID: 22281255.
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    9. DeMaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S. Highlights of the year in JACC 2010. J Am Coll Cardiol. 2011 Jan 25; 57(4):480-514. PMID: 21251590.
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    10. Sugano Y, Lai NC, Gao MH, Firth AL, Yuan JX, Lew WY, Hammond HK. Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart. Biochem Biophys Res Commun. 2011 Feb 18; 405(3):349-55. PMID: 21195051.
      View in: PubMed
    11. Villarreal F, Lew WY. Protein quality control in heart disease: using established drugs to target novel mechanisms. J Am Coll Cardiol. 2010 Oct 19; 56(17):1427-9. PMID: 20947001.
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    12. DeMaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S. Highlights of the Year in JACC 2009. J Am Coll Cardiol. 2010 Jan 26; 55(4):380-407. PMID: 20117446.
      View in: PubMed
    13. Shannon TR, Lew WY. Diastolic release of calcium from the sarcoplasmic reticulum: a potential target for treating triggered arrhythmias and heart failure. J Am Coll Cardiol. 2009 May 26; 53(21):2006-8. PMID: 19460615.
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    14. DeMaria AN, Ben-Yehuda O, Bax JJ, Feld GK, Greenberg BH, Lew WY, Lima JA, Maisel AS, Narayan SM, Sahn DJ, Tsimikas S. Highlights of the Year in JACC 2008. J Am Coll Cardiol. 2009 Jan 27; 53(4):373-98. PMID: 19161890.
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    15. DeMaria AN, Bax JJ, Ben-Yehuda O, Clopton P, Feld GK, Ginsburg GS, Greenberg BH, Knoke JD, Lew WY, Lima JA, Maisel AS, Narayan SM, Narula J, Sahn DJ, Tsimikas S. Highlights of the year in JACC 2007. J Am Coll Cardiol. 2008 Jan 29; 51(4):490-512. PMID: 18222362.
      View in: PubMed
    16. Lew WY. A cool heart protected from infarction: clinical translation of breathing chilled liquids. J Am Coll Cardiol. 2007 Feb 06; 49(5):606-7. PMID: 17276186.
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    17. DeMaria AN, Ben-Yehuda O, Feld GK, Ginsburg GS, Greenberg BH, Lew WY, Lima JA, Maisel AS, Narula J, Sahn DJ, Tsimikas S. Highlights of the Year in JACC 2006. J Am Coll Cardiol. 2007 Jan 30; 49(4):509-27. PMID: 17258099.
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    18. Suzuki J, Bayna E, Li HL, Molle ED, Lew WY. Lipopolysaccharide activates calcineurin in ventricular myocytes. J Am Coll Cardiol. 2007 Jan 30; 49(4):491-9. PMID: 17258096.
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    19. Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, Saito M, Lew WY, Clopton P, Hammond HK. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation. 2006 Aug 01; 114(5):388-96. PMID: 16864723.
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    20. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Ginsberg J, Greenberg BH, Lew WY, Sahn D, Tsimikas S. Highlights of the Year in JACC 2005. J Am Coll Cardiol. 2006 Jan 03; 47(1):184-202. PMID: 16386685.
      View in: PubMed
    21. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Narula J, Sahn D, Tsimikas S. Highlights of the year in JACC 2004. J Am Coll Cardiol. 2005 Jan 04; 45(1):137-53. PMID: 15629388.
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    22. Lew WY. Mobilizing cells to the injured myocardium: a novel rescue strategy or an unwelcome intrusion? J Am Coll Cardiol. 2004 Oct 06; 44(7):1521-2. PMID: 15464337.
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    23. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Tsimikas S. Highlights of the year in JACC 2003. J Am Coll Cardiol. 2003 Dec 17; 42(12):2156-66. PMID: 15560019.
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    24. Lew WY. Endotoxin attacks the cardiovascular system: black death at the tollgate. J Am Coll Cardiol. 2003 Nov 05; 42(9):1663-5. PMID: 14607456.
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    25. Suzuki J, Bayna E, Dalle Molle E, Lew WY. Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats. J Am Coll Cardiol. 2003 Feb 05; 41(3):482-8. PMID: 12575980.
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    26. Li HL, Suzuki J, Bayna E, Zhang FM, Dalle Molle E, Clark A, Engler RL, Lew WY. Lipopolysaccharide induces apoptosis in adult rat ventricular myocytes via cardiac AT(1) receptors. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H461-7. PMID: 12124189.
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    27. He H, Meyer M, Martin JL, McDonough PM, Ho P, Lou X, Lew WY, Hilal-Dandan R, Dillmann WH. Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility. Circulation. 1999 Aug 31; 100(9):974-80. PMID: 10468529.
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    28. Yasuda S, Lew WY. Angiotensin II exacerbates lipopolysaccharide-induced contractile depression in rabbit cardiac myocytes. Am J Physiol. 1999 05; 276(5):H1442-9. PMID: 10330226.
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    29. Meyer M, Bluhm WF, He H, Post SR, Giordano FJ, Lew WY, Dillmann WH. Phospholamban-to-SERCA2 ratio controls the force-frequency relationship. Am J Physiol. 1999 03; 276(3):H779-85. PMID: 10070059.
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    30. Bluhm WF, Lew WY, Garfinkel A, McCulloch AD. Mechanisms of length history-dependent tension in an ionic model of the cardiac myocyte. Am J Physiol. 1998 03; 274(3):H1032-40. PMID: 9530218.
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    31. Bluhm WF, Sung D, Lew WY, Garfinkel A, McCulloch AD. Cellular mechanisms for the slow phase of the Frank-Starling response. J Electrocardiol. 1998; 31 Suppl:13-22. PMID: 9988000.
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    32. Yasuda S, Lew WY. Lipopolysaccharide depresses cardiac contractility and beta-adrenergic contractile response by decreasing myofilament response to Ca2+ in cardiac myocytes. Circ Res. 1997 Dec; 81(6):1011-20. PMID: 9400382.
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    33. Yasuda S, Lew WY. Endothelin-1 ameliorates contractile depression by lipopolysaccharide in cardiac myocytes. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1403-7. PMID: 9321831.
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    34. Lew WY, Lee M, Yasuda S, Bayna E. Depyrogenation of digestive enzymes reduces lipopolysaccharide tolerance in isolated cardiac myocytes. J Mol Cell Cardiol. 1997 Jul; 29(7):1985-90. PMID: 9236152.
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    35. Lew WY, Ryan J, Yasuda S. Lipopolysaccharide induces cell shrinkage in rabbit ventricular cardiac myocytes. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2989-93. PMID: 9227578.
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    36. Lew WY, Yasuda S, Yuan T, Hammond HK. Endotoxin-induced cardiac depression is associated with decreased cardiac dihydropyridine receptors in rabbits. J Mol Cell Cardiol. 1996 Jun; 28(6):1367-71. PMID: 8782078.
      View in: PubMed
    37. Nishikawa Y, Mathison J, Lew WY. Serum tumor necrosis factor-alpha does not mediate endotoxin-induced myocardial depression in rabbits. Am J Physiol. 1996 Feb; 270(2 Pt 2):H485-91. PMID: 8779822.
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    38. Bluhm WF, McCulloch AD, Lew WY. Active force in rabbit ventricular myocytes. J Biomech. 1995 Sep; 28(9):1119-22. PMID: 7559682.
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    39. Nishikawa Y, Lew WY. Endotoxin-induced left ventricular depression is blocked by nitrogen mustard or dimethylthiourea in rabbits. Am J Physiol. 1995 Sep; 269(3 Pt 2):H1098-105. PMID: 7573507.
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    40. Bluhm WF, Lew WY. Sarcoplasmic reticulum in cardiac length-dependent activation in rabbits. Am J Physiol. 1995 Sep; 269(3 Pt 2):H965-72. PMID: 7573541.
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    41. Lew WY. Asynchrony and ryanodine modulate load-dependent relaxation in the canine left ventricle. Am J Physiol. 1995 Jan; 268(1 Pt 2):H17-24. PMID: 7840261.
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    42. Lew WY, Nishikawa Y, Su H. Cardiac myocyte function and left ventricular strains after brief ischemia and reperfusion in rabbits. Circulation. 1994 Oct; 90(4):1942-50. PMID: 7923683.
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    43. Lew WY. Mechanisms of volume-induced increase in left ventricular contractility. Am J Physiol. 1993 Nov; 265(5 Pt 2):H1778-86. PMID: 8238591.
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    44. Hung J, Lew WY. Temporal sequence of endotoxin-induced systolic and diastolic myocardial depression in rabbits. Am J Physiol. 1993 Sep; 265(3 Pt 2):H810-9. PMID: 8214114.
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    45. Hung J, Lew WY. Cellular mechanisms of endotoxin-induced myocardial depression in rabbits. Circ Res. 1993 Jul; 73(1):125-34. PMID: 8508524.
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    46. Whang KK, Lee MG, Lew W, Lee JB. Production and characterization of monoclonal antibodies to Treponema pallidum. J Dermatol Sci. 1992 Jul; 4(1):26-32. PMID: 1390455.
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    47. Lew WY, Hryshko LV, Bers DM. Dihydropyridine receptors are primarily functional L-type calcium channels in rabbit ventricular myocytes. Circ Res. 1991 Oct; 69(4):1139-45. PMID: 1657438.
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    48. Gillebert TC, Lew WY. Influence of systolic pressure profile on rate of left ventricular pressure fall. Am J Physiol. 1991 Sep; 261(3 Pt 2):H805-13. PMID: 1887926.
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    49. Villarreal FJ, Lew WY, Waldman LK, Covell JW. Transmural myocardial deformation in the ischemic canine left ventricle. Circ Res. 1991 Feb; 68(2):368-81. PMID: 1991344.
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    50. Villarreal FJ, Lew WY. Finite strains in anterior and posterior wall of canine left ventricle. Am J Physiol. 1990 Nov; 259(5 Pt 2):H1409-18. PMID: 2240241.
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    51. Hoit BD, LeWinter M, Lew WY. Independent influence of left atrial pressure on regional peak lengthening rates. Am J Physiol. 1990 Aug; 259(2 Pt 2):H480-7. PMID: 2386222.
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    52. Gillebert TC, Lew WY. Nonuniformity and volume loading independently influence isovolumic relaxation rates. Am J Physiol. 1989 Dec; 257(6 Pt 2):H1927-35. PMID: 2603977.
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    53. Lew WY. Evaluation of left ventricular diastolic function. Circulation. 1989 Jun; 79(6):1393-7. PMID: 2498007.
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    54. Lew WY, Rasmussen CM. Influence of nonuniformity on rate of left ventricular pressure fall in the dog. Am J Physiol. 1989 Jan; 256(1 Pt 2):H222-32. PMID: 2912186.
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    55. Hoit BD, Lew WY, LeWinter M. Regional variation in pericardial contact pressure in the canine ventricle. Am J Physiol. 1988 Dec; 255(6 Pt 2):H1370-7. PMID: 3202201.
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    56. Lew WY. Time-dependent increase in left ventricular contractility following acute volume loading in the dog. Circ Res. 1988 Sep; 63(3):635-47. PMID: 2457459.
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    57. Hoit BD, Lew WY. Functional consequences of acute anterior vs. posterior wall ischemia in canine left ventricles. Am J Physiol. 1988 Jun; 254(6 Pt 2):H1065-73. PMID: 3381894.
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    58. Villarreal FJ, Waldman LK, Lew WY. Technique for measuring regional two-dimensional finite strains in canine left ventricle. Circ Res. 1988 Apr; 62(4):711-21. PMID: 3349574.
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    59. Guth BD, White FC, Widmann T, Lew W, Bloor CM. Decreased regional contractility in nonischemic myocardium during acute coronary artery occlusion in conscious pigs. Am J Cardiovasc Pathol. 1988; 1(3):379-87. PMID: 3207482.
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    60. Morris D, Mulvihill D, Lew WY. Risk of developing complete heart block during bedside pulmonary artery catheterization in patients with left bundle-branch block. Arch Intern Med. 1987 Nov; 147(11):2005-10. PMID: 3675104.
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    61. Assanelli D, Lew WY, Shabetai R, LeWinter MM. Influence of the pericardium on right and left ventricular filling in the dog. J Appl Physiol (1985). 1987 Sep; 63(3):1025-32. PMID: 3654452.
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    62. Lew WY. Influence of ischemic zone size on nonischemic area function in the canine left ventricle. Am J Physiol. 1987 May; 252(5 Pt 2):H990-7. PMID: 3578547.
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    63. Mann D, Lew W, Ban-Hayashi E, Shabetai R, Waldman L, LeWinter MM. In vivo mechanical behavior of canine pericardium. Am J Physiol. 1986 Aug; 251(2 Pt 2):H349-56. PMID: 3740289.
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    64. Way B, Victory J, LeWinter MM, Lew WY, Doyle R, Foëx P, Ryder WA, Jones LA. Hysteresis of left ventricular end ejection pressure-dimension relations after acute pressure loading in the intact canine heart. Cardiovasc Res. 1986 Jul; 20(7):490-7. PMID: 3779745.
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    65. Lew WY, LeWinter MM. Regional comparison of midwall segment and area shortening in the canine left ventricle. Circ Res. 1986 May; 58(5):678-91. PMID: 3708765.
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    66. Cheung AK, LeWinter M, Chenoweth DE, Lew WY, Henderson LW. Cardiopulmonary effects of cuprophane-activated plasma in the swine. Kidney Int. 1986 Apr; 29(4):799-806. PMID: 3086612.
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    67. Lew WY, Longhurst JC. Substance P, 5-hydroxytryptamine, and bradykinin stimulate abdominal visceral afferents. Am J Physiol. 1986 Mar; 250(3 Pt 2):R465-73. PMID: 2420215.
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    68. Lew WY, Goldberger AL. Torsades de pointes and sudden death in a patient with a permanent pacemaker. Can J Cardiol. 1986 Mar-Apr; 2(2):86-7. PMID: 3635423.
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    69. Lew WY, Ban-Hayashi E. Mechanisms of improving regional and global ventricular function by preload alterations during acute ischemia in the canine left ventricle. Circulation. 1985 Nov; 72(5):1125-34. PMID: 4042300.
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    70. Lew WY, Chen ZY, Guth B, Covell JW. Mechanisms of augmented segment shortening in nonischemic areas during acute ischemia of the canine left ventricle. Circ Res. 1985 Mar; 56(3):351-8. PMID: 3971509.
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    71. Lew WY, LeWinter MM. Regional circumferential lengthening patterns in canine left ventricle. Am J Physiol. 1983 Nov; 245(5 Pt 1):H741-8. PMID: 6638197.
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    72. Mancini GB, Bloomquist JN, Bhargava V, Stein JB, Lew W, Slutsky RA, Shabetai R, Higgins CB. Hemodynamic and electrocardiographic effects in man of a new nonionic contrast agent (iohexol): advantages over standard ionic agents. Am J Cardiol. 1983 Apr; 51(7):1218-22. PMID: 6837464.
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    73. Mancini GB, Costello D, Bhargava V, Lew W, LeWinter M, Karliner JS. The isovolumic index: a new noninvasive approach to the assessment of left ventricular function in man. Am J Cardiol. 1982 Dec; 50(6):1401-8. PMID: 7148720.
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    74. Lew W, Henning H, Schelbert H, Karliner JS. Assessment of mitral valve E point-septal separation as an index of left ventricular performance in patients with acute and previous myocardial infarction. Am J Cardiol. 1978 May 01; 41(5):836-45. PMID: 645591.
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