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Roger Spragg

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #9111
La Jolla CA 92093
Phone8/6-42--1248
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    Collapse Biography 
    Collapse Education and Training
    Wesleyan University, Middletown, CTBA1965Mathematics
    University of Rochester, Rochester, NYMD1969Medicine
    University of California, San Diego, San Diego, CA1969Internal Medicne
    NHLBI, NIH, Bethesda, MD1971Medicine
    University of California, San Diego, San Diego, CA1973Internal Medicine
    University of California, San Diego, San Diego, CA1975Pulmonary/Critical Care Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Spragg’s academic interests include mechanisms of acute lung injury, design and oversight of critical care studies, and mentoring fellows and junior faculty.

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016 Sep; 42(9):1427-36. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D. PMID: 27342819.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    2. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May; 43(5):1026-35. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. PMID: 25738857.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    3. Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung. J Cell Physiol. 2013 Feb; 228(2):371-9. Breen EC, Malloy JL, Tang K, Xia F, Fu Z, Hancock RE, Overhage J, Wagner PD, Spragg RG. PMID: 22718316.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy. Chest. 2012 Jan; 141(1):27-35. Kerr KM, Auger WR, Marsh JJ, Devendra G, Spragg RG, Kim NH, Channick RN, Jamieson SW, Madani MM, Manecke GR, Roth DM, Shragg GP, Fedullo PF. PMID: 21835900.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    5. Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):1055-61. Spragg RG, Taut FJ, Lewis JF, Schenk P, Ruppert C, Dean N, Krell K, Karabinis A, Günther A. PMID: 21148720.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    6. An informatics strategy to assure enrollment criteria compliance in studies of the critically ill. Contemp Clin Trials. 2010 Nov; 31(6):530-5. Spragg RG, Masys DR, Sergeant D, Lawrie T, Taut FJ. PMID: 20667511.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med. 2010 May 15; 181(10):1121-7. Spragg RG, Bernard GR, Checkley W, Curtis JR, Gajic O, Guyatt G, Hall J, Israel E, Jain M, Needham DM, Randolph AG, Rubenfeld GD, Schoenfeld D, Thompson BT, Ware LB, Young D, Harabin AL. PMID: 20224063.
      View in: PubMed   Mentions: 101     Fields:    Translation:Humans
    8. Surfactant replacement therapy in ARDS. Chest. 2009 Jul; 136(1):321-322. Spragg RG, Taut FJH, Günther A, Rippin G. PMID: 19584221.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. A Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute). Chest. 2008 Oct; 134(4):724-32. Taut FJ, Rippin G, Schenk P, Findlay G, Wurst W, Häfner D, Lewis JF, Seeger W, Günther A, Spragg RG. PMID: 18689599.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    10. Surfactant for acute lung injury. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):377-8. Spragg R. PMID: 17872593.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    11. Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Crit Care. 2006; 10(2):R41. Davidson WJ, Dorscheid D, Spragg R, Schulzer M, Mak E, Ayas NT. PMID: 16542488.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    12. A 12-month clinical survey of incidence and outcome of acute respiratory distress syndrome in Shanghai intensive care units. Intensive Care Med. 2004 Dec; 30(12):2197-203. Lu Y, Song Z, Zhou X, Huang S, Zhu D, Yang C Bai X, Sun B, Spragg R. PMID: 15650866.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    13. Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med. 2004 Aug 26; 351(9):884-92. Spragg RG, Lewis JF, Walmrath HD, Johannigman J, Bellingan G, Laterre PF, Witte MC, Richards GA, Rippin G, Rathgeb F, Häfner D, Taut FJ, Seeger W. PMID: 15329426.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCTClinical Trials
    14. Surfactant from diving aquatic mammals. J Appl Physiol (1985). 2004 May; 96(5):1626-32. Spragg RG, Ponganis PJ, Marsh JJ, Rau GA, Bernhard W. PMID: 14688033.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Acute lung injury in 2003. Acta Pharmacol Sin. 2003 Dec; 24(12):1288-91. Spragg RG. PMID: 14653959.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant. Am J Respir Crit Care Med. 2003 Jun 01; 167(11):1562-6. Spragg RG, Lewis JF, Wurst W, Häfner D, Baughman RP, Wewers MD, Marsh JJ. PMID: 12649125.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCTClinical Trials
    17. Effect of CTP:phosphocholine cytidylyltransferase overexpression on the mouse lung surfactant system. Am J Respir Cell Mol Biol. 2002 Jun; 26(6):709-15. Li J, Marsh JJ, Spragg RG. PMID: 12034570.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Lung surfactant in subacute pulmonary disease. Respir Res. 2002; 3:19. Devendra G, Spragg RG. PMID: 11980588.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    19. The future of surfactant therapy for patients with acute lung injury - new requirements and new surfactants. Biol Neonate. 2002; 81 Suppl 1:20-4. Spragg RG. PMID: 12011562.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    20. Pathology of the surfactant system of the mature lung: second San Diego conference. Am J Respir Crit Care Med. 2001 Jan; 163(1):280-2. Spragg RG, Lewis JF. PMID: 11208658.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Surfactant replacement therapy. Clin Chest Med. 2000 Sep; 21(3):531-41, ix. Spragg RG. PMID: 11019725.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    22. ARDS and the search for meaningful subgroups. Intensive Care Med. 2000 Jul; 26(7):835-7. Spragg RG, Levin D. PMID: 10990094.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Reperfusion lung injury after unilateral pulmonary artery occlusion. Respirology. 2000 Jun; 5(2):133-40. Permpikul C, Wang HY, Kriett J, Konopka RG, Moser KM, Spragg RG. PMID: 10894102.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    24. Effect of recombinant SP-C surfactant in a porcine lavage model of acute lung injury. J Appl Physiol (1985). 2000 Feb; 88(2):674-81. Spragg RG, Smith RM, Harris K, Lewis J, Häfner D, Germann P. PMID: 10658037.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    25. Effect of phosphocholine cytidylyltransferase overexpression on phosphatidylcholine synthesis in alveolar type II cells and related cell lines. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):116-24. Spragg RG, Li J. PMID: 10615073.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Dosing and delivery of a recombinant surfactant in lung-injured adult sheep. Am J Respir Crit Care Med. 1999 Mar; 159(3):741-7. Lewis J, McCaig L, Häfner D, Spragg R, Veldhuizen R, Kerr C. PMID: 10051245.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    27. Surfactant therapy in acute respiratory distress syndrome. Biol Neonate. 1998 Sep; 74 Suppl 1:15-20. Spragg RG. PMID: 9730587.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    28. Analyzing the time and value of housestaff inpatient work. J Gen Intern Med. 1998 Aug; 13(8):534-40. Dresselhaus TR, Luck J, Wright BC, Spragg RG, Lee ML, Bozzette SA. PMID: 9734790.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    29. Sustained submaximal exercise does not alter the integrity of the lung blood-gas barrier in elite athletes. J Appl Physiol (1985). 1998 Apr; 84(4):1185-9. Hopkins SR, Schoene RB, Henderson WR, Spragg RG, West JB. PMID: 9516183.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    30. The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998 Apr; 157(4 Pt 1):1332-47. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. PMID: 9563759.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    31. The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling. Intensive Care Med. 1998 Apr; 24(4):378-98. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. PMID: 9609420.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    32. Bovine surfactant therapy for patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 1997 Apr; 155(4):1309-15. Gregory TJ, Steinberg KP, Spragg R, Gadek JE, Hyers TM, Longmore WJ, Moxley MA, Cai GZ, Hite RD, Smith RM, Hudson LD, Crim C, Newton P, Mitchell BR, Gold AJ. PMID: 9105072.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCTClinical Trials
    33. Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes. Am J Respir Crit Care Med. 1997 Mar; 155(3):1090-4. Hopkins SR, Schoene RB, Henderson WR, Spragg RG, Martin TR, West JB. PMID: 9116992.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    34. Pathology of the surfactant system of the mature lung. Am J Respir Crit Care Med. 1997 Feb; 155(2):756-60. Spragg RG, Smith RM. PMID: 9032225.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    35. Human SP-A locus: allele frequencies and linkage disequilibrium between the two surfactant protein A genes. Am J Respir Cell Mol Biol. 1996 Oct; 15(4):489-98. Floros J, DiAngelo S, Koptides M, Karinch AM, Rogan PK, Nielsen H, Spragg RG, Watterberg K, Deiter G. PMID: 8879183.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    36. Inhibition of the human neutrophil respiratory burst by native and synthetic surfactant. Am J Respir Cell Mol Biol. 1996 May; 14(5):496-503. Ahuja A, Oh N, Chao W, Spragg RG, Smith RM. PMID: 8624255.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    37. Effect of N-nitroso-N-methylurethane on gas exchange, lung compliance, and surfactant function of rabbits. Intensive Care Med. 1996 Apr; 22(4):345-52. Pappert D, Gilliard N, Heldt G, Merritt TA, Wagner PD, Spragg RG. PMID: 8708173.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    38. Parathyroid hormone-related protein, an autocrine regulatory factor in alveolar epithelial cells. Am J Physiol. 1996 Mar; 270(3 Pt 1):L353-61. Hastings RH, Summers-Torres D, Cheung TC, Ditmer LS, Petrin EM, Burton DW, Spragg RG, Li J, Deftos LJ. PMID: 8638727.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    39. Inhibitory effect of porcine surfactant on the respiratory burst oxidase in human neutrophils. Attenuation of p47phox and p67phox membrane translocation as the mechanism. J Clin Invest. 1995 Dec; 96(6):2654-60. Chao W, Spragg RG, Smith RM. PMID: 8675631.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. Fractal analysis of surfactant deposition in rabbit lungs. J Appl Physiol (1985). 1995 Mar; 78(3):862-6. Gilliard N, Pappert D, Spragg RG. PMID: 7775330.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    41. Exposure of the hydrophobic components of porcine lung surfactant to oxidant stress alters surface tension properties. J Clin Invest. 1994 Jun; 93(6):2608-15. Gilliard N, Heldt GP, Loredo J, Gasser H, Redl H, Merritt TA, Spragg RG. PMID: 8200999.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    42. Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee. J Crit Care. 1994 Mar; 9(1):72-81. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. PMID: 8199655.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    43. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994 Mar; 149(3 Pt 1):818-24. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. PMID: 7509706.
      View in: PubMed   Mentions: 1321     Fields:    Translation:Humans
    44. Making progress. Intensive Care Med. 1994; 20(1):4-5. Spragg R. PMID: 8163756.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome. Chest. 1994 Jan; 105(1):195-202. Spragg RG, Gilliard N, Richman P, Smith RM, Hite RD, Pappert D, Robertson B, Curstedt T, Strayer D. PMID: 8031347.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCTClinical Trials
    46. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med. 1994; 20(3):225-32. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. PMID: 8014293.
      View in: PubMed   Mentions: 142     Fields:    Translation:Humans
    47. H2O2 increases expression of pulmonary artery endothelial cell platelet-derived growth factor mRNA. J Appl Physiol (1985). 1992 Dec; 73(6):2255-62. Montisano DF, Mann T, Spragg RG. PMID: 1490932.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    48. Distribution of surfactant, lung compliance, and aeration of preterm rabbit lungs after surfactant therapy and conventional and high-frequency oscillatory ventilation. Pediatr Res. 1992 Mar; 31(3):270-5. Heldt GP, Merritt TA, Golembeski D, Gilliard N, Bloor C, Spragg R. PMID: 1561014.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    49. The impact of concomitant viral pathogens on the course of Pneumocystis carinii pneumonia. J Protozool. 1991 Nov-Dec; 38(6):183S-184S. Bozzette SA, Arcia J, Bartok AE, McGlynn LM, McCutchan JA, Richman DD, Spragg R, Spector SA. PMID: 1667929.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    50. Radiolabeling of the hydrophobic components of lung surfactant with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine. Anal Biochem. 1991 Mar 02; 193(2):310-5. Gilliard N, Pappert D, Merritt TA, Heldt G, Spragg RG. PMID: 1872476.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    51. DNA strand break formation following exposure of bovine pulmonary artery and aortic endothelial cells to reactive oxygen products. Am J Respir Cell Mol Biol. 1991 Jan; 4(1):4-10. Spragg RG. PMID: 1846077.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    52. Effect of volume and dose on the pulmonary distribution of exogenous surfactant administered to normal rabbits or to rabbits with oleic acid lung injury. Am Rev Respir Dis. 1990 Mar; 141(3):743-7. Gilliard N, Richman PM, Merritt TA, Spragg RG. PMID: 2310102.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    53. Pulmonary deposition and clearance of aerosolized alpha-1-proteinase inhibitor administered to dogs and to sheep. J Clin Invest. 1989 Oct; 84(4):1145-54. Smith RM, Traber LD, Traber DL, Spragg RG. PMID: 2794051.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    54. Exogenous surfactant treatments for neonatal respiratory distress syndrome and their potential role in the adult respiratory distress syndrome. Drugs. 1989 Oct; 38(4):591-611. Merritt TA, Hallman M, Spragg R, Heldt GP, Gilliard N. PMID: 2684594.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    55. The adult respiratory distress syndrome: first trials with surfactant replacement. Eur Respir J Suppl. 1989 Mar; 3:109s-111s. Richman PS, Spragg RG, Robertson B, Merritt TA, Curstedt T. PMID: 2742681.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    56. The use of exogenous surfactant to treat patients with acute high-permeability lung edema. Prog Clin Biol Res. 1989; 308:791-6. Spragg RG, Richman P, Gilliard N, Merritt TA, Robertson B, Curstedt T. PMID: 2675070.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Immunologic consequences of exogenous surfactant administration. Semin Perinatol. 1988 Jul; 12(3):221-30. Merritt TA, Strayer DS, Hallman M, Spragg RD, Wozniak P. PMID: 3041605.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCTClinical Trials
    58. Production and administration to dogs of aerosols of alpha-1-proteinase inhibitor. Am J Med. 1988 Jun 24; 84(6A):48-51. Smith RM, Spragg RG. PMID: 3260073.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    59. Intravenous administration of alpha-1-proteinase inhibitor in patients of PiZ and PiM phenotype. Preliminary report. Am J Med. 1988 Jun 24; 84(6A):70-4. Moser KM, Smith RM, Spragg RG, Tisi GM. PMID: 3260074.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    60. Ethical decisions in discontinuing mechanical ventilation. N Engl J Med. 1988 Apr 14; 318(15):984-8. Schneiderman LJ, Spragg RG. PMID: 3352689.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    61. Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J Biol Chem. 1988 Feb 05; 263(4):1665-75. Hyslop PA, Hinshaw DB, Halsey WA, Schraufstätter IU, Sauerheber RD, Spragg RG, Jackson JH, Cochrane CG. PMID: 3338986.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    62. Pulmonary penetration of alpha 1-proteinase inhibitor administered parenterally to dogs. Am Rev Respir Dis. 1987 Dec; 136(6):1391-6. Smith RM, Spragg RG, Moser KM, Cochrane CG, McCarren JP. PMID: 3120632.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    63. Oxidant injury of cultured cells: biochemical consequences. Prog Clin Biol Res. 1987; 236A:253-8. Spragg RG, Schraufstatter IU, Hyslop PA, Hinshaw DB, Cochrane CG. PMID: 3112791.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    64. Biologic availability of injected or aerosolized alpha 1 proteinase inhibitor. Prog Clin Biol Res. 1987; 236A:203-10. Smith RM, Spragg RG, Moser KM. PMID: 3497405.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    65. Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D1 cells. J Cell Physiol. 1986 Dec; 129(3):356-66. Hyslop PA, Hinshaw DB, Schraufstätter IU, Sklar LA, Spragg RG, Cochrane CG. PMID: 3782310.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    66. Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase. Proc Natl Acad Sci U S A. 1986 Jul; 83(13):4908-12. Schraufstatter IU, Hyslop PA, Hinshaw DB, Spragg RG, Sklar LA, Cochrane CG. PMID: 2941760.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    67. Cytoskeletal and morphologic impact of cellular oxidant injury. Am J Pathol. 1986 Jun; 123(3):454-64. Hinshaw DB, Sklar LA, Bohl B, Schraufstatter IU, Hyslop PA, Rossi MW, Spragg RG, Cochrane CG. PMID: 3717299.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    68. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest. 1986 Apr; 77(4):1312-20. Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG. PMID: 2937805.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    69. Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury. J Clin Invest. 1985 Oct; 76(4):1471-6. Spragg RG, Hinshaw DB, Hyslop PA, Schraufstätter IU, Cochrane CG. PMID: 2997279.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    70. Distribution of ventilation in American alligator Alligator mississippiensis. Am J Physiol. 1985 Oct; 249(4 Pt 2):R477-81. Bickler PE, Spragg RG, Hartman MT, White FN. PMID: 4051034.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    71. Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells. J Clin Invest. 1985 Sep; 76(3):1131-9. Schraufstätter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG. PMID: 3840176.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    72. Mechanisms of interaction between oxygen and granulocytes in hyperoxic lung injury. J Appl Physiol (1985). 1985 Apr; 58(4):1326-30. Krieger BP, Loomis WH, Czer GT, Spragg RG. PMID: 3838744.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    73. Endobronchial surface active phospholipids in various pulmonary diseases. Eur J Respir Dis Suppl. 1985; 142:37-47. Hallman M, Arjomaa P, Tahvanainen J, Lachmann B, Spragg R. PMID: 3860395.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    74. The in vivo behavior of granulocytes labeled with indium-111 in a canine model of pneumococcal pneumonia. Am Rev Respir Dis. 1984 Apr; 129(4):602-6. Lichter JP, Konopka RG, Hartman MT, Moser KM, Spragg RG. PMID: 6712001.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    75. Nonspecificity of elevated angiotensin-converting enzyme activity in bronchoalveolar lavage fluid from high permeability lung edema states. Am Rev Respir Dis. 1984 Mar; 129(3):499-500. Krieger B, Schwartz J, Loomis W, Marsh J, Spragg R. PMID: 6322628.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    76. Granulocytes and hyperoxia act synergistically in causing acute lung injury. Exp Lung Res. 1984; 7(2):77-83. Krieger BP, Loomis WH, Spragg RG. PMID: 6525983.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    77. Effect of histamine and propranolol on extravascular lung water. Am J Physiol. 1984 Jan; 246(1 Pt 2):H69-73. Schwartz JS, Konopka RG, Spragg RG. PMID: 6696090.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    78. Chronic thrombotic obstruction of major pulmonary arteries. Results of thromboendarterectomy in 15 patients. Ann Intern Med. 1983 Sep; 99(3):299-304. Moser KM, Spragg RG, Utley J, Daily PO. PMID: 6614679.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    79. Angiosarcoma of the lung with fatal pulmonary hemorrhage. Am J Med. 1983 Jun; 74(6):1072-6. Spragg RG, Wolf PL, Haghighi P, Abraham JL, Astarita RW. PMID: 6683073.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    80. Biochemical factors in pulmonary inflammatory disease. Chest. 1983 May; 83(5 Suppl):67S-70S. Cochrane CG, Spragg RG, Revak SD, Schraufstatter I. PMID: 6340987.
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    81. Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid. J Clin Invest. 1983 Mar; 71(3):754-61. Cochrane CG, Spragg R, Revak SD. PMID: 6600748.
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    82. The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Am Rev Respir Dis. 1983 Feb; 127(2):S25-7. Cochrane CG, Spragg RG, Revak SD, Cohen AB, McGuire WW. PMID: 6550478.
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    83. Use of the balloon-tipped pulmonary artery catheter in pulmonary disease. Ann Intern Med. 1983 Jan; 98(1):53-8. Moser KM, Spragg RG. PMID: 6848045.
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    84. Pulmonary endarterectomy for chronic thromboembolic obstruction: recent surgical experience. Surgery. 1982 Dec; 92(6):1096-102. Utley JR, Spragg RG, Long WB, Moser KM. PMID: 7147187.
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    85. New methods for the performance of unilateral lung lavage. Anesthesiology. 1982 Dec; 57(6):535-8. Spragg RG, Benumof JL, Alfery DD. PMID: 7149310.
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    86. Right and left ventricular response to subcutaneous terbutaline in patients with chronic obstructive pulmonary disease: radionuclide angiographic assessment of cardiac size and function. Am Heart J. 1982 Nov; 104(5 Pt 1):1027-32. Hooper WW, Slutsky RA, Kocienski DE, Witztum KF, Spragg RG, Ashburn WL, Moser KM. PMID: 7136993.
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    87. Lung mucociliary transport during high-frequency ventilation. Am Rev Respir Dis. 1982 Sep; 126(3):452-6. McEvoy RD, Davies NJ, Hedenstierna G, Hartman MT, Spragg RG, Wagner PD. PMID: 6751174.
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    88. Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol. J Clin Invest. 1982 Sep; 70(3):673-83. Hallman M, Spragg R, Harrell JH, Moser KM, Gluck L. PMID: 6896715.
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    89. Pulmonary platelet deposition accompanying acute oleic-acid-induced pulmonary injury. Am Rev Respir Dis. 1982 Sep; 126(3):553-7. Spragg RG, Abraham JL, Loomis WH. PMID: 7125342.
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    90. Large cavitary dead space as an unusual cause of hypercapnic respiratory failure in pulmonary tuberculosis. Thorax. 1982 Jul; 37(7):550-1. Shure D, Spragg RG, Moser KM. PMID: 7135301.
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    91. Studies on the pathogenesis of the adult respiratory distress syndrome. J Clin Invest. 1982 Mar; 69(3):543-53. McGuire WW, Spragg RG, Cohen AB, Cochrane CG. PMID: 7037851.
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    92. The labeling of rabbit neutrophils with [111In]oxine. J Immunol Methods. 1982; 51(3):293-305. Lane TA, Bergum PW, Lichter JP, Spragg RG. PMID: 6809833.
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    93. Deep venous thrombosis and pulmonary embolism. Frequency in a respiratory intensive care unit. JAMA. 1981 Sep 25; 246(13):1422-4. Moser KM, LeMoine JR, Nachtwey FJ, Spragg RG. PMID: 7265445.
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    94. Study of factors that may condition scintigraphic detection of venous thrombi and pulmonary emboli with indium-111-labeled platelets. J Nucl Med. 1980 Nov; 21(11):1051-8. Moser KM, Spragg RG, Bender F, Konopka R, Hartman MT, Fedullo P. PMID: 7431104.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    95. Distribution of ventilation in the turtle Pseudemys scripta. Respir Physiol. 1980 Oct; 42(1):73-87. Spragg RG, Ackerman R, White FN. PMID: 7444225.
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    96. Cardiopulmonary consequences of decompression stress. Respir Physiol. 1980 Aug; 41(2):143-53. Neuman TS, Spragg RG, Wagner PD, Moser KM. PMID: 6776599.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    97. Letter: Adult respiratory distress syndrome associated with colchicine intoxication. Ann Intern Med. 1975 Oct; 83(4):523-4. Hill RN, Spragg RG, Wedel MK, Moser KM. PMID: 1166987.
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    98. Platelet kinetics in venovenous membrane oxygenation. Trans Am Soc Artif Intern Organs. 1975; 21:171-7. Spragg RG, Hill RN, Wedel MK, Materson A, Moser KM. PMID: 1145990.
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    99. Adult respiratory distress syndrome: early predictors of mortality. Trans Am Soc Artif Intern Organs. 1975; 21:199-205. Hill RN, Shibel EM, Spragg RG, Moser KM. PMID: 1145992.
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