Roger Spragg

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Wesleyan University, Middletown, CTBA1965Mathematics
    University of Rochester, Rochester, NYMD1969Medicine
    University of California, San Diego, San Diego, CA1969Internal Medicne
    NHLBI, NIH, Bethesda, MD1971Medicine
    University of California, San Diego, San Diego, CA1973Internal Medicine
    University of California, San Diego, San Diego, CA1975Pulmonary/Critical Care Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Spragg’s academic interests include mechanisms of acute lung injury, design and oversight of critical care studies, and mentoring fellows and junior faculty.

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Very Low Driving-Pressure Ventilation in Patients With COVID-19 Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation: A Physiologic Study. J Cardiothorac Vasc Anesth. 2023 03; 37(3):423-431. Odish M, Pollema T, Meier A, Hepokoski M, Yi C, Spragg R, Patel HH, Alexander LEC, Sun XS, Jain S, Simonson TS, Malhotra A, Owens RL. PMID: 36567221; PMCID: PMC9701579.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Association Between Acute Kidney Injury During Invasive Mechanical Ventilation and ICU Outcomes and Respiratory System Mechanics. Crit Care Explor. 2022 Jul; 4(7):e0720. Vemuri SV, Rolfsen ML, Sykes AV, Takiar PG, Leonard AJ, Malhotra A, Spragg RG, Macedo E, Hepokoski ML. PMID: 35782295; PMCID: PMC9246080.
      View in: PubMed   Mentions: 6  
    3. Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L84-L92. Hepokoski ML, Odish M, Lam MT, Coufal NG, Rolfsen ML, Shadel GS, Moyzis AG, Sainz AG, Takiar PG, Patel S, Leonard AJ, Samandari N, Hansen E, Trescott S, Nguyen C, Jepsen K, Cutter G, Gillespie MN, Spragg RG, Sasik R, Ix JH. PMID: 35699291; PMCID: PMC9273271.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    4. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016 Sep; 42(9):1427-36. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D. PMID: 27342819; PMCID: PMC4992404.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    5. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May; 43(5):1026-35. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. PMID: 25738857; PMCID: PMC4400228.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    6. Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung. J Cell Physiol. 2013 Feb; 228(2):371-9. Breen EC, Malloy JL, Tang K, Xia F, Fu Z, Hancock RE, Overhage J, Wagner PD, Spragg RG. PMID: 22718316; PMCID: PMC3484242.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy. Chest. 2012 Jan; 141(1):27-35. Kerr KM, Auger WR, Marsh JJ, Devendra G, Spragg RG, Kim NH, Channick RN, Jamieson SW, Madani MM, Manecke GR, Roth DM, Shragg GP, Fedullo PF. PMID: 21835900; PMCID: PMC3251267.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    8. Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):1055-61. Spragg RG, Taut FJ, Lewis JF, Schenk P, Ruppert C, Dean N, Krell K, Karabinis A, Günther A. PMID: 21148720.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    9. An informatics strategy to assure enrollment criteria compliance in studies of the critically ill. Contemp Clin Trials. 2010 Nov; 31(6):530-5. Spragg RG, Masys DR, Sergeant D, Lawrie T, Taut FJ. PMID: 20667511.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med. 2010 May 15; 181(10):1121-7. Spragg RG, Bernard GR, Checkley W, Curtis JR, Gajic O, Guyatt G, Hall J, Israel E, Jain M, Needham DM, Randolph AG, Rubenfeld GD, Schoenfeld D, Thompson BT, Ware LB, Young D, Harabin AL. PMID: 20224063; PMCID: PMC2874454.
      View in: PubMed   Mentions: 136     Fields:    Translation:Humans
    11. Surfactant replacement therapy in ARDS. Chest. 2009 Jul; 136(1):321-322. Spragg RG, Taut FJH, Günther A, Rippin G. PMID: 19584221.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. A Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute). Chest. 2008 Oct; 134(4):724-732. Taut FJH, Rippin G, Schenk P, Findlay G, Wurst W, Häfner D, Lewis JF, Seeger W, Günther A, Spragg RG. PMID: 18689599.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    13. Surfactant for acute lung injury. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):377-8. Spragg R. PMID: 17872593.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    14. Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Crit Care. 2006; 10(2):R41. Davidson WJ, Dorscheid D, Spragg R, Schulzer M, Mak E, Ayas NT. PMID: 16542488; PMCID: PMC1550886.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    15. A 12-month clinical survey of incidence and outcome of acute respiratory distress syndrome in Shanghai intensive care units. Intensive Care Med. 2004 Dec; 30(12):2197-203. Lu Y, Song Z, Zhou X, Huang S, Zhu D, Yang C Bai X, Sun B, Spragg R, Shanghai ARDS Study Group. PMID: 15650866.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    16. Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med. 2004 Aug 26; 351(9):884-92. Spragg RG, Lewis JF, Walmrath HD, Johannigman J, Bellingan G, Laterre PF, Witte MC, Richards GA, Rippin G, Rathgeb F, Häfner D, Taut FJ, Seeger W. PMID: 15329426.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCTClinical Trials
    17. Surfactant from diving aquatic mammals. J Appl Physiol (1985). 2004 May; 96(5):1626-32. Spragg RG, Ponganis PJ, Marsh JJ, Rau GA, Bernhard W. PMID: 14688033.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    18. Acute lung injury in 2003. Acta Pharmacol Sin. 2003 Dec; 24(12):1288-91. Spragg RG. PMID: 14653959.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant. Am J Respir Crit Care Med. 2003 Jun 01; 167(11):1562-6. Spragg RG, Lewis JF, Wurst W, Häfner D, Baughman RP, Wewers MD, Marsh JJ. PMID: 12649125.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCTClinical Trials
    20. Effect of CTP:phosphocholine cytidylyltransferase overexpression on the mouse lung surfactant system. Am J Respir Cell Mol Biol. 2002 Jun; 26(6):709-15. Li J, Marsh JJ, Spragg RG. PMID: 12034570.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. Lung surfactant in subacute pulmonary disease. Respir Res. 2002; 3:19. Devendra G, Spragg RG. PMID: 11980588; PMCID: PMC107848.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    22. The future of surfactant therapy for patients with acute lung injury - new requirements and new surfactants. Biol Neonate. 2002; 81 Suppl 1:20-4. Spragg RG. PMID: 12011562.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    23. Pathology of the surfactant system of the mature lung: second San Diego conference. Am J Respir Crit Care Med. 2001 Jan; 163(1):280-2. Spragg RG, Lewis JF. PMID: 11208658.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Surfactant replacement therapy. Clin Chest Med. 2000 Sep; 21(3):531-41, ix. Spragg RG. PMID: 11019725.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    25. ARDS and the search for meaningful subgroups. Intensive Care Med. 2000 Jul; 26(7):835-7. Spragg RG, Levin D. PMID: 10990094.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Reperfusion lung injury after unilateral pulmonary artery occlusion. Respirology. 2000 Jun; 5(2):133-40. Permpikul C, Wang HY, Kriett J, Konopka RG, Moser KM, Spragg RG. PMID: 10894102.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    27. Effect of recombinant SP-C surfactant in a porcine lavage model of acute lung injury. J Appl Physiol (1985). 2000 Feb; 88(2):674-81. Spragg RG, Smith RM, Harris K, Lewis J, Häfner D, Germann P. PMID: 10658037.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    28. Effect of phosphocholine cytidylyltransferase overexpression on phosphatidylcholine synthesis in alveolar type II cells and related cell lines. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):116-24. Spragg RG, Li J. PMID: 10615073.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    29. Dosing and delivery of a recombinant surfactant in lung-injured adult sheep. Am J Respir Crit Care Med. 1999 Mar; 159(3):741-7. Lewis J, McCaig L, Häfner D, Spragg R, Veldhuizen R, Kerr C. PMID: 10051245.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    30. Surfactant therapy in acute respiratory distress syndrome. Biol Neonate. 1998 Sep; 74 Suppl 1:15-20. Spragg RG. PMID: 9730587.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    31. Analyzing the time and value of housestaff inpatient work. J Gen Intern Med. 1998 Aug; 13(8):534-40. Dresselhaus TR, Luck J, Wright BC, Spragg RG, Lee ML, Bozzette SA. PMID: 9734790; PMCID: PMC1497006.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    32. The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling. Intensive Care Med. 1998 Apr; 24(4):378-98. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. PMID: 9609420.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    33. Sustained submaximal exercise does not alter the integrity of the lung blood-gas barrier in elite athletes. J Appl Physiol (1985). 1998 Apr; 84(4):1185-9. Hopkins SR, Schoene RB, Henderson WR, Spragg RG, West JB. PMID: 9516183.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    34. The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998 Apr; 157(4 Pt 1):1332-47. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. PMID: 9563759.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    35. Bovine surfactant therapy for patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 1997 Apr; 155(4):1309-15. Gregory TJ, Steinberg KP, Spragg R, Gadek JE, Hyers TM, Longmore WJ, Moxley MA, Cai GZ, Hite RD, Smith RM, Hudson LD, Crim C, Newton P, Mitchell BR, Gold AJ. PMID: 9105072.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCTClinical Trials
    36. Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes. Am J Respir Crit Care Med. 1997 Mar; 155(3):1090-4. Hopkins SR, Schoene RB, Henderson WR, Spragg RG, Martin TR, West JB. PMID: 9116992.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    37. Pathology of the surfactant system of the mature lung. Am J Respir Crit Care Med. 1997 Feb; 155(2):756-60. Spragg RG, Smith RM. PMID: 9032225.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    38. Human SP-A locus: allele frequencies and linkage disequilibrium between the two surfactant protein A genes. Am J Respir Cell Mol Biol. 1996 Oct; 15(4):489-98. Floros J, DiAngelo S, Koptides M, Karinch AM, Rogan PK, Nielsen H, Spragg RG, Watterberg K, Deiter G. PMID: 8879183.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    39. Inhibition of the human neutrophil respiratory burst by native and synthetic surfactant. Am J Respir Cell Mol Biol. 1996 May; 14(5):496-503. Ahuja A, Oh N, Chao W, Spragg RG, Smith RM. PMID: 8624255.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    40. Effect of N-nitroso-N-methylurethane on gas exchange, lung compliance, and surfactant function of rabbits. Intensive Care Med. 1996 Apr; 22(4):345-52. Pappert D, Gilliard N, Heldt G, Merritt TA, Wagner PD, Spragg RG. PMID: 8708173.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    41. Parathyroid hormone-related protein, an autocrine regulatory factor in alveolar epithelial cells. Am J Physiol. 1996 Mar; 270(3 Pt 1):L353-61. Hastings RH, Summers-Torres D, Cheung TC, Ditmer LS, Petrin EM, Burton DW, Spragg RG, Li J, Deftos LJ. PMID: 8638727.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    42. Inhibitory effect of porcine surfactant on the respiratory burst oxidase in human neutrophils. Attenuation of p47phox and p67phox membrane translocation as the mechanism. J Clin Invest. 1995 Dec; 96(6):2654-60. Chao W, Spragg RG, Smith RM. PMID: 8675631; PMCID: PMC185971.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    43. Fractal analysis of surfactant deposition in rabbit lungs. J Appl Physiol (1985). 1995 Mar; 78(3):862-6. Gilliard N, Pappert D, Spragg RG. PMID: 7775330.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    44. Exposure of the hydrophobic components of porcine lung surfactant to oxidant stress alters surface tension properties. J Clin Invest. 1994 Jun; 93(6):2608-15. Gilliard N, Heldt GP, Loredo J, Gasser H, Redl H, Merritt TA, Spragg RG. PMID: 8200999; PMCID: PMC294496.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    45. Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee. J Crit Care. 1994 Mar; 9(1):72-81. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. PMID: 8199655.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    46. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994 Mar; 149(3 Pt 1):818-24. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. PMID: 7509706.
      View in: PubMed   Mentions: 1720     Fields:    Translation:Humans
    47. Making progress. Intensive Care Med. 1994; 20(1):4-5. Spragg R. PMID: 8163756.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome. Chest. 1994 Jan; 105(1):195-202. Spragg RG, Gilliard N, Richman P, Smith RM, Hite RD, Pappert D, Robertson B, Curstedt T, Strayer D. PMID: 8031347.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCTClinical Trials
    49. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med. 1994; 20(3):225-32. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. PMID: 8014293.
      View in: PubMed   Mentions: 188     Fields:    Translation:Humans
    50. H2O2 increases expression of pulmonary artery endothelial cell platelet-derived growth factor mRNA. J Appl Physiol (1985). 1992 Dec; 73(6):2255-62. Montisano DF, Mann T, Spragg RG. PMID: 1490932.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    51. Distribution of surfactant, lung compliance, and aeration of preterm rabbit lungs after surfactant therapy and conventional and high-frequency oscillatory ventilation. Pediatr Res. 1992 Mar; 31(3):270-5. Heldt GP, Merritt TA, Golembeski D, Gilliard N, Bloor C, Spragg R. PMID: 1561014.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    52. The impact of concomitant viral pathogens on the course of Pneumocystis carinii pneumonia. J Protozool. 1991 Nov-Dec; 38(6):183S-184S. Bozzette SA, Arcia J, Bartok AE, McGlynn LM, McCutchan JA, Richman DD, Spragg R, Spector SA. PMID: 1667929.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    53. Radiolabeling of the hydrophobic components of lung surfactant with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine. Anal Biochem. 1991 Mar 02; 193(2):310-5. Gilliard N, Pappert D, Merritt TA, Heldt G, Spragg RG. PMID: 1872476.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    54. DNA strand break formation following exposure of bovine pulmonary artery and aortic endothelial cells to reactive oxygen products. Am J Respir Cell Mol Biol. 1991 Jan; 4(1):4-10. Spragg RG. PMID: 1846077.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    55. Effect of volume and dose on the pulmonary distribution of exogenous surfactant administered to normal rabbits or to rabbits with oleic acid lung injury. Am Rev Respir Dis. 1990 Mar; 141(3):743-7. Gilliard N, Richman PM, Merritt TA, Spragg RG. PMID: 2310102.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    56. Exogenous surfactant treatments for neonatal respiratory distress syndrome and their potential role in the adult respiratory distress syndrome. Drugs. 1989 Oct; 38(4):591-611. Merritt TA, Hallman M, Spragg R, Heldt GP, Gilliard N. PMID: 2684594.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    57. Pulmonary deposition and clearance of aerosolized alpha-1-proteinase inhibitor administered to dogs and to sheep. J Clin Invest. 1989 Oct; 84(4):1145-54. Smith RM, Traber LD, Traber DL, Spragg RG. PMID: 2794051; PMCID: PMC329771.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    58. The adult respiratory distress syndrome: first trials with surfactant replacement. Eur Respir J Suppl. 1989 Mar; 3:109s-111s. Richman PS, Spragg RG, Robertson B, Merritt TA, Curstedt T. PMID: 2742681.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    59. The use of exogenous surfactant to treat patients with acute high-permeability lung edema. Prog Clin Biol Res. 1989; 308:791-6. Spragg RG, Richman P, Gilliard N, Merritt TA, Robertson B, Curstedt T. PMID: 2675070.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    60. Immunologic consequences of exogenous surfactant administration. Semin Perinatol. 1988 Jul; 12(3):221-30. Merritt TA, Strayer DS, Hallman M, Spragg RD, Wozniak P. PMID: 3041605.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCTClinical Trials
    61. Production and administration to dogs of aerosols of alpha-1-proteinase inhibitor. Am J Med. 1988 Jun 24; 84(6A):48-51. Smith RM, Spragg RG. PMID: 3260073.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    62. Intravenous administration of alpha-1-proteinase inhibitor in patients of PiZ and PiM phenotype. Preliminary report. Am J Med. 1988 Jun 24; 84(6A):70-4. Moser KM, Smith RM, Spragg RG, Tisi GM. PMID: 3260074.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    63. Ethical decisions in discontinuing mechanical ventilation. N Engl J Med. 1988 Apr 14; 318(15):984-8. Schneiderman LJ, Spragg RG. PMID: 3352689.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    64. Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J Biol Chem. 1988 Feb 05; 263(4):1665-75. Hyslop PA, Hinshaw DB, Halsey WA, Schraufstätter IU, Sauerheber RD, Spragg RG, Jackson JH, Cochrane CG. PMID: 3338986.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    65. Pulmonary penetration of alpha 1-proteinase inhibitor administered parenterally to dogs. Am Rev Respir Dis. 1987 Dec; 136(6):1391-6. Smith RM, Spragg RG, Moser KM, Cochrane CG, McCarren JP. PMID: 3120632.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    66. Oxidant injury of cultured cells: biochemical consequences. Prog Clin Biol Res. 1987; 236A:253-8. Spragg RG, Schraufstatter IU, Hyslop PA, Hinshaw DB, Cochrane CG. PMID: 3112791.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    67. Biologic availability of injected or aerosolized alpha 1 proteinase inhibitor. Prog Clin Biol Res. 1987; 236A:203-10. Smith RM, Spragg RG, Moser KM. PMID: 3497405.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    68. Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D1 cells. J Cell Physiol. 1986 Dec; 129(3):356-66. Hyslop PA, Hinshaw DB, Schraufstätter IU, Sklar LA, Spragg RG, Cochrane CG. PMID: 3782310.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    69. Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase. Proc Natl Acad Sci U S A. 1986 Jul; 83(13):4908-12. Schraufstatter IU, Hyslop PA, Hinshaw DB, Spragg RG, Sklar LA, Cochrane CG. PMID: 2941760; PMCID: PMC323853.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    70. Cytoskeletal and morphologic impact of cellular oxidant injury. Am J Pathol. 1986 Jun; 123(3):454-64. Hinshaw DB, Sklar LA, Bohl B, Schraufstatter IU, Hyslop PA, Rossi MW, Spragg RG, Cochrane CG. PMID: 3717299; PMCID: PMC1888261.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    71. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest. 1986 Apr; 77(4):1312-20. Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG. PMID: 2937805; PMCID: PMC424485.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    72. Distribution of ventilation in American alligator Alligator mississippiensis. Am J Physiol. 1985 Oct; 249(4 Pt 2):R477-81. Bickler PE, Spragg RG, Hartman MT, White FN. PMID: 4051034.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    73. Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury. J Clin Invest. 1985 Oct; 76(4):1471-6. Spragg RG, Hinshaw DB, Hyslop PA, Schraufstätter IU, Cochrane CG. PMID: 2997279; PMCID: PMC424106.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    74. Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells. J Clin Invest. 1985 Sep; 76(3):1131-9. Schraufstätter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG. PMID: 3840176; PMCID: PMC424005.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    75. Mechanisms of interaction between oxygen and granulocytes in hyperoxic lung injury. J Appl Physiol (1985). 1985 Apr; 58(4):1326-30. Krieger BP, Loomis WH, Czer GT, Spragg RG. PMID: 3838744.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    76. Endobronchial surface active phospholipids in various pulmonary diseases. Eur J Respir Dis Suppl. 1985; 142:37-47. Hallman M, Arjomaa P, Tahvanainen J, Lachmann B, Spragg R. PMID: 3860395.
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    77. The in vivo behavior of granulocytes labeled with indium-111 in a canine model of pneumococcal pneumonia. Am Rev Respir Dis. 1984 Apr; 129(4):602-6. Lichter JP, Konopka RG, Hartman MT, Moser KM, Spragg RG. PMID: 6712001.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    78. Nonspecificity of elevated angiotensin-converting enzyme activity in bronchoalveolar lavage fluid from high permeability lung edema states. Am Rev Respir Dis. 1984 Mar; 129(3):499-500. Krieger B, Schwartz J, Loomis W, Marsh J, Spragg R. PMID: 6322628.
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    79. Granulocytes and hyperoxia act synergistically in causing acute lung injury. Exp Lung Res. 1984; 7(2):77-83. Krieger BP, Loomis WH, Spragg RG. PMID: 6525983.
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    80. Effect of histamine and propranolol on extravascular lung water. Am J Physiol. 1984 Jan; 246(1 Pt 2):H69-73. Schwartz JS, Konopka RG, Spragg RG. PMID: 6696090.
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    81. Chronic thrombotic obstruction of major pulmonary arteries. Results of thromboendarterectomy in 15 patients. Ann Intern Med. 1983 Sep; 99(3):299-304. Moser KM, Spragg RG, Utley J, Daily PO. PMID: 6614679.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    82. Angiosarcoma of the lung with fatal pulmonary hemorrhage. Am J Med. 1983 Jun; 74(6):1072-6. Spragg RG, Wolf PL, Haghighi P, Abraham JL, Astarita RW. PMID: 6683073.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    83. Biochemical factors in pulmonary inflammatory disease. Chest. 1983 May; 83(5 Suppl):67S-70S. Cochrane CG, Spragg RG, Revak SD, Schraufstatter I. PMID: 6340987.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    84. Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid. J Clin Invest. 1983 Mar; 71(3):754-61. Cochrane CG, Spragg R, Revak SD. PMID: 6600748; PMCID: PMC436926.
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    85. The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Am Rev Respir Dis. 1983 Feb; 127(2):S25-7. Cochrane CG, Spragg RG, Revak SD, Cohen AB, McGuire WW. PMID: 6550478.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    86. Use of the balloon-tipped pulmonary artery catheter in pulmonary disease. Ann Intern Med. 1983 Jan; 98(1):53-8. Moser KM, Spragg RG. PMID: 6848045.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    87. New methods for the performance of unilateral lung lavage. Anesthesiology. 1982 Dec; 57(6):535-8. Spragg RG, Benumof JL, Alfery DD. PMID: 7149310.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    88. Pulmonary endarterectomy for chronic thromboembolic obstruction: recent surgical experience. Surgery. 1982 Dec; 92(6):1096-102. Utley JR, Spragg RG, Long WB, Moser KM. PMID: 7147187.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    89. Right and left ventricular response to subcutaneous terbutaline in patients with chronic obstructive pulmonary disease: radionuclide angiographic assessment of cardiac size and function. Am Heart J. 1982 Nov; 104(5 Pt 1):1027-32. Hooper WW, Slutsky RA, Kocienski DE, Witztum KF, Spragg RG, Ashburn WL, Moser KM. PMID: 7136993.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    90. Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol. J Clin Invest. 1982 Sep; 70(3):673-83. Hallman M, Spragg R, Harrell JH, Moser KM, Gluck L. PMID: 6896715; PMCID: PMC370271.
      View in: PubMed   Mentions: 100     Fields:    Translation:Humans
    91. Pulmonary platelet deposition accompanying acute oleic-acid-induced pulmonary injury. Am Rev Respir Dis. 1982 Sep; 126(3):553-7. Spragg RG, Abraham JL, Loomis WH. PMID: 7125342.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    92. Lung mucociliary transport during high-frequency ventilation. Am Rev Respir Dis. 1982 Sep; 126(3):452-6. McEvoy RD, Davies NJ, Hedenstierna G, Hartman MT, Spragg RG, Wagner PD. PMID: 6751174.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    93. Large cavitary dead space as an unusual cause of hypercapnic respiratory failure in pulmonary tuberculosis. Thorax. 1982 Jul; 37(7):550-1. Shure D, Spragg RG, Moser KM. PMID: 7135301; PMCID: PMC459369.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    94. Studies on the pathogenesis of the adult respiratory distress syndrome. J Clin Invest. 1982 Mar; 69(3):543-53. McGuire WW, Spragg RG, Cohen AB, Cochrane CG. PMID: 7037851; PMCID: PMC371010.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    95. The labeling of rabbit neutrophils with [111In]oxine. J Immunol Methods. 1982; 51(3):293-305. Lane TA, Bergum PW, Lichter JP, Spragg RG. PMID: 6809833.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    96. Deep venous thrombosis and pulmonary embolism. Frequency in a respiratory intensive care unit. JAMA. 1981 Sep 25; 246(13):1422-4. Moser KM, LeMoine JR, Nachtwey FJ, Spragg RG. PMID: 7265445.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    97. Study of factors that may condition scintigraphic detection of venous thrombi and pulmonary emboli with indium-111-labeled platelets. J Nucl Med. 1980 Nov; 21(11):1051-8. Moser KM, Spragg RG, Bender F, Konopka R, Hartman MT, Fedullo P. PMID: 7431104.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    98. Distribution of ventilation in the turtle Pseudemys scripta. Respir Physiol. 1980 Oct; 42(1):73-87. Spragg RG, Ackerman R, White FN. PMID: 7444225.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    99. Cardiopulmonary consequences of decompression stress. Respir Physiol. 1980 Aug; 41(2):143-53. Neuman TS, Spragg RG, Wagner PD, Moser KM. PMID: 6776599.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    100. Letter: Adult respiratory distress syndrome associated with colchicine intoxication. Ann Intern Med. 1975 Oct; 83(4):523-4. Hill RN, Spragg RG, Wedel MK, Moser KM. PMID: 1166987.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    101. Platelet kinetics in venovenous membrane oxygenation. Trans Am Soc Artif Intern Organs. 1975; 21:171-7. Spragg RG, Hill RN, Wedel MK, Materson A, Moser KM. PMID: 1145990.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    102. Adult respiratory distress syndrome: early predictors of mortality. Trans Am Soc Artif Intern Organs. 1975; 21:199-205. Hill RN, Shibel EM, Spragg RG, Moser KM. PMID: 1145992.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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