Loading...

Roger Spragg

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #9111
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    PATHOLOGY OF THE SURFACTANT SYSTEM OF THE MATURE LUNG
    NIH/NHLBI R13HL062421Aug 23, 1999 - Aug 22, 2000
    Role: Principal Investigator
    SURFACTANT PATHOLOGY IN THE MATURE LUNG
    NIH/NHLBI R13HL052526Sep 1, 1994 - Aug 31, 1995
    Role: Principal Investigator
    MECHANISMS OF LUNG CELL OXIDANT INJURY
    NIH/NHLBI R01HL036270Apr 1, 1986 - Mar 31, 1992
    Role: Principal Investigator
    SCOR IN ACUTE LUNG INJURY
    NIH/NHLBI P50HL023584Dec 1, 1978 - Nov 30, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg R, Matthay MA, Thompson BT, Talmor D. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016 Sep; 42(9):1427-36. PMID: 27342819; PMCID: PMC4992404 [Available on 09/01/17].
    2. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg R, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May; 43(5):1026-35. PMID: 25738857; PMCID: PMC4400228.
    3. Breen EC, Malloy JL, Tang K, Xia F, Fu Z, Hancock RE, Overhage J, Wagner PD, Spragg R. Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung. J Cell Physiol. 2013 Feb; 228(2):371-9. PMID: 22718316; PMCID: PMC3484242.
    4. Kerr KM, Auger WR, Marsh JJ, Devendra G, Spragg R, Kim NH, Channick RN, Jamieson SW, Madani MM, Manecke GR, Roth DM, Shragg GP, Fedullo PF. Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy. Chest. 2012 Jan; 141(1):27-35. PMID: 21835900; PMCID: PMC3251267.
    5. Spragg R, Taut FJ, Lewis JF, Schenk P, Ruppert C, Dean N, Krell K, Karabinis A, Günther A. Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):1055-61. PMID: 21148720.
      View in: PubMed
    6. Spragg R, Masys DR, Sergeant D, Lawrie T, Taut FJ. An informatics strategy to assure enrollment criteria compliance in studies of the critically ill. Contemp Clin Trials. 2010 Nov; 31(6):530-5. PMID: 20667511.
      View in: PubMed
    7. Spragg R, Bernard GR, Checkley W, Curtis JR, Gajic O, Guyatt G, Hall J, Israel E, Jain M, Needham DM, Randolph AG, Rubenfeld GD, Schoenfeld D, Thompson BT, Ware LB, Young D, Harabin AL. Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med. 2010 May 15; 181(10):1121-7. PMID: 20224063; PMCID: PMC2874454.
    8. Spragg R, Taut FJH, Günther A, Rippin G. Surfactant replacement therapy in ARDS. Chest. 2009 Jul; 136(1):321-322. PMID: 19584221.
      View in: PubMed
    9. Taut FJ, Rippin G, Schenk P, Findlay G, Wurst W, Häfner D, Lewis JF, Seeger W, Günther A, Spragg R. A Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute). Chest. 2008 Oct; 134(4):724-32. PMID: 18689599.
      View in: PubMed
    10. Spragg R. Surfactant for acute lung injury. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):377-8. PMID: 17872593.
      View in: PubMed
    11. Davidson WJ, Dorscheid D, Spragg R, Schulzer M, Mak E, Ayas NT. Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Crit Care. 2006; 10(2):R41. PMID: 16542488; PMCID: PMC1550886.
    12. Lu Y, Song Z, Zhou X, Huang S, Zhu D, Yang C Bai X, Sun B, Spragg R. A 12-month clinical survey of incidence and outcome of acute respiratory distress syndrome in Shanghai intensive care units. Intensive Care Med. 2004 Dec; 30(12):2197-203. PMID: 15650866.
      View in: PubMed
    13. Spragg R, Lewis JF, Walmrath HD, Johannigman J, Bellingan G, Laterre PF, Witte MC, Richards GA, Rippin G, Rathgeb F, Häfner D, Taut FJ, Seeger W. Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med. 2004 Aug 26; 351(9):884-92. PMID: 15329426.
      View in: PubMed
    14. Spragg R, Ponganis PJ, Marsh JJ, Rau GA, Bernhard W. Surfactant from diving aquatic mammals. J Appl Physiol (1985). 2004 May; 96(5):1626-32. PMID: 14688033.
      View in: PubMed
    15. Spragg R. Acute lung injury in 2003. Acta Pharmacol Sin. 2003 Dec; 24(12):1288-91. PMID: 14653959.
      View in: PubMed
    16. Spragg R, Lewis JF, Wurst W, Häfner D, Baughman RP, Wewers MD, Marsh JJ. Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant. Am J Respir Crit Care Med. 2003 Jun 01; 167(11):1562-6. PMID: 12649125.
      View in: PubMed
    17. Li J, Marsh JJ, Spragg R. Effect of CTP:phosphocholine cytidylyltransferase overexpression on the mouse lung surfactant system. Am J Respir Cell Mol Biol. 2002 Jun; 26(6):709-15. PMID: 12034570.
      View in: PubMed
    18. Devendra G, Spragg R. Lung surfactant in subacute pulmonary disease. Respir Res. 2002; 3:19. PMID: 11980588; PMCID: PMC107848.
    19. Spragg R. The future of surfactant therapy for patients with acute lung injury - new requirements and new surfactants. Biol Neonate. 2002; 81 Suppl 1:20-4. PMID: 12011562.
      View in: PubMed
    20. Spragg R, Lewis JF. Pathology of the surfactant system of the mature lung: second San Diego conference. Am J Respir Crit Care Med. 2001 Jan; 163(1):280-2. PMID: 11208658.
      View in: PubMed
    21. Spragg R. Surfactant replacement therapy. Clin Chest Med. 2000 Sep; 21(3):531-41, ix. PMID: 11019725.
      View in: PubMed
    22. Spragg R, Smith RM, Harris K, Lewis J, Häfner D, Germann P. Effect of recombinant SP-C surfactant in a porcine lavage model of acute lung injury. J Appl Physiol (1985). 2000 Feb; 88(2):674-81. PMID: 10658037.
      View in: PubMed
    23. Spragg R, Li J. Effect of phosphocholine cytidylyltransferase overexpression on phosphatidylcholine synthesis in alveolar type II cells and related cell lines. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):116-24. PMID: 10615073.
      View in: PubMed