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    Roger Spragg

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #9111
    CA La Jolla 92093
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      PATHOLOGY OF THE SURFACTANT SYSTEM OF THE MATURE LUNG
      NIH/NHLBI R13HL062421Aug 23, 1999 - Aug 22, 2000
      Role: Principal Investigator
      SURFACTANT PATHOLOGY IN THE MATURE LUNG
      NIH/NHLBI R13HL052526Sep 1, 1994 - Aug 31, 1995
      Role: Principal Investigator
      MECHANISMS OF LUNG CELL OXIDANT INJURY
      NIH/NHLBI R01HL036270Apr 1, 1986 - Mar 31, 1992
      Role: Principal Investigator
      SCOR IN ACUTE LUNG INJURY
      NIH/NHLBI P50HL023584Dec 1, 1978 - Nov 30, 2003
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg R, Matthay MA, Thompson BT, Talmor D. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016 Sep; 42(9):1427-36. PMID: 27342819; PMCID: PMC4992404 [Available on 09/01/17].
      2. Breen EC, Malloy JL, Tang K, Xia F, Fu Z, Hancock RE, Overhage J, Wagner PD, Spragg R. Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung. J Cell Physiol. 2013 Feb; 228(2):371-9. PMID: 22718316; PMCID: PMC3484242.
      3. Kerr KM, Auger WR, Marsh JJ, Devendra G, Spragg R, Kim NH, Channick RN, Jamieson SW, Madani MM, Manecke GR, Roth DM, Shragg GP, Fedullo PF. Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy. Chest. 2012 Jan; 141(1):27-35. PMID: 21835900; PMCID: PMC3251267.
      4. Spragg R, Taut FJ, Lewis JF, Schenk P, Ruppert C, Dean N, Krell K, Karabinis A, Günther A. Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):1055-61. PMID: 21148720.
        View in: PubMed
      5. Spragg R, Masys DR, Sergeant D, Lawrie T, Taut FJ. An informatics strategy to assure enrollment criteria compliance in studies of the critically ill. Contemp Clin Trials. 2010 Nov; 31(6):530-5. PMID: 20667511.
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      6. Spragg R, Bernard GR, Checkley W, Curtis JR, Gajic O, Guyatt G, Hall J, Israel E, Jain M, Needham DM, Randolph AG, Rubenfeld GD, Schoenfeld D, Thompson BT, Ware LB, Young D, Harabin AL. Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med. 2010 May 15; 181(10):1121-7. PMID: 20224063; PMCID: PMC2874454.
      7. Spragg R, Taut FJH, Günther A, Rippin G. Surfactant replacement therapy in ARDS. Chest. 2009 Jul; 136(1):321-322. PMID: 19584221.
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      8. Taut FJ, Rippin G, Schenk P, Findlay G, Wurst W, Häfner D, Lewis JF, Seeger W, Günther A, Spragg R. A Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute). Chest. 2008 Oct; 134(4):724-32. PMID: 18689599.
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      9. Spragg R. Surfactant for acute lung injury. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):377-8. PMID: 17872593.
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      10. Davidson WJ, Dorscheid D, Spragg R, Schulzer M, Mak E, Ayas NT. Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Crit Care. 2006; 10(2):R41. PMID: 16542488; PMCID: PMC1550886.
      11. Lu Y, Song Z, Zhou X, Huang S, Zhu D, Yang C Bai X, Sun B, Spragg R. A 12-month clinical survey of incidence and outcome of acute respiratory distress syndrome in Shanghai intensive care units. Intensive Care Med. 2004 Dec; 30(12):2197-203. PMID: 15650866.
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      12. Spragg R, Lewis JF, Walmrath HD, Johannigman J, Bellingan G, Laterre PF, Witte MC, Richards GA, Rippin G, Rathgeb F, Häfner D, Taut FJ, Seeger W. Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med. 2004 Aug 26; 351(9):884-92. PMID: 15329426.
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      13. Spragg R, Ponganis PJ, Marsh JJ, Rau GA, Bernhard W. Surfactant from diving aquatic mammals. J Appl Physiol (1985). 2004 May; 96(5):1626-32. PMID: 14688033.
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      14. Spragg R. Acute lung injury in 2003. Acta Pharmacol Sin. 2003 Dec; 24(12):1288-91. PMID: 14653959.
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      15. Spragg R, Lewis JF, Wurst W, Häfner D, Baughman RP, Wewers MD, Marsh JJ. Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant. Am J Respir Crit Care Med. 2003 Jun 01; 167(11):1562-6. PMID: 12649125.
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      16. Li J, Marsh JJ, Spragg R. Effect of CTP:phosphocholine cytidylyltransferase overexpression on the mouse lung surfactant system. Am J Respir Cell Mol Biol. 2002 Jun; 26(6):709-15. PMID: 12034570.
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      17. Devendra G, Spragg R. Lung surfactant in subacute pulmonary disease. Respir Res. 2002; 3:19. PMID: 11980588; PMCID: PMC107848.
      18. Spragg R. The future of surfactant therapy for patients with acute lung injury - new requirements and new surfactants. Biol Neonate. 2002; 81 Suppl 1:20-4. PMID: 12011562.
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      19. Spragg R, Lewis JF. Pathology of the surfactant system of the mature lung: second San Diego conference. Am J Respir Crit Care Med. 2001 Jan; 163(1):280-2. PMID: 11208658.
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      20. Spragg R. Surfactant replacement therapy. Clin Chest Med. 2000 Sep; 21(3):531-41, ix. PMID: 11019725.
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      21. Spragg R, Levin D. ARDS and the search for meaningful subgroups. Intensive Care Med. 2000 Jul; 26(7):835-7. PMID: 10990094.
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      22. Permpikul C, Wang HY, Kriett J, Konopka RG, Moser KM, Spragg R. Reperfusion lung injury after unilateral pulmonary artery occlusion. Respirology. 2000 Jun; 5(2):133-40. PMID: 10894102.
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      23. Spragg R, Smith RM, Harris K, Lewis J, Häfner D, Germann P. Effect of recombinant SP-C surfactant in a porcine lavage model of acute lung injury. J Appl Physiol (1985). 2000 Feb; 88(2):674-81. PMID: 10658037.
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      24. Spragg R, Li J. Effect of phosphocholine cytidylyltransferase overexpression on phosphatidylcholine synthesis in alveolar type II cells and related cell lines. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):116-24. PMID: 10615073.
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      25. Lewis J, McCaig L, Häfner D, Spragg R, Veldhuizen R, Kerr C. Dosing and delivery of a recombinant surfactant in lung-injured adult sheep. Am J Respir Crit Care Med. 1999 Mar; 159(3):741-7. PMID: 10051245.
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      26. Spragg R. Surfactant therapy in acute respiratory distress syndrome. Biol Neonate. 1998 Sep; 74 Suppl 1:15-20. PMID: 9730587.
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      27. Dresselhaus TR, Luck J, Wright BC, Spragg R, Lee ML, Bozzette SA. Analyzing the time and value of housestaff inpatient work. J Gen Intern Med. 1998 Aug; 13(8):534-40. PMID: 9734790; PMCID: PMC1497006.
      28. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998 Apr; 157(4 Pt 1):1332-47. PMID: 9563759.
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      29. Hopkins SR, Schoene RB, Henderson WR, Spragg R, West JB. Sustained submaximal exercise does not alter the integrity of the lung blood-gas barrier in elite athletes. J Appl Physiol (1985). 1998 Apr; 84(4):1185-9. PMID: 9516183.
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      30. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling. Intensive Care Med. 1998 Apr; 24(4):378-98. PMID: 9609420.
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      31. Gregory TJ, Steinberg KP, Spragg R, Gadek JE, Hyers TM, Longmore WJ, Moxley MA, Cai GZ, Hite RD, Smith RM, Hudson LD, Crim C, Newton P, Mitchell BR, Gold AJ. Bovine surfactant therapy for patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 1997 Apr; 155(4):1309-15. PMID: 9105072.
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      32. Hopkins SR, Schoene RB, Henderson WR, Spragg R, Martin TR, West JB. Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes. Am J Respir Crit Care Med. 1997 Mar; 155(3):1090-4. PMID: 9116992.
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      33. Spragg R, Smith RM. Pathology of the surfactant system of the mature lung. Am J Respir Crit Care Med. 1997 Feb; 155(2):756-60. PMID: 9032225.
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      34. Floros J, DiAngelo S, Koptides M, Karinch AM, Rogan PK, Nielsen H, Spragg R, Watterberg K, Deiter G. Human SP-A locus: allele frequencies and linkage disequilibrium between the two surfactant protein A genes. Am J Respir Cell Mol Biol. 1996 Oct; 15(4):489-98. PMID: 8879183.
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      35. Ahuja A, Oh N, Chao W, Spragg R, Smith RM. Inhibition of the human neutrophil respiratory burst by native and synthetic surfactant. Am J Respir Cell Mol Biol. 1996 May; 14(5):496-503. PMID: 8624255.
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      36. Pappert D, Gilliard N, Heldt G, Merritt TA, Wagner PD, Spragg R. Effect of N-nitroso-N-methylurethane on gas exchange, lung compliance, and surfactant function of rabbits. Intensive Care Med. 1996 Apr; 22(4):345-52. PMID: 8708173.
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      37. Hastings RH, Summers-Torres D, Cheung TC, Ditmer LS, Petrin EM, Burton DW, Spragg R, Li J, Deftos LJ. Parathyroid hormone-related protein, an autocrine regulatory factor in alveolar epithelial cells. Am J Physiol. 1996 Mar; 270(3 Pt 1):L353-61. PMID: 8638727.
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      38. Chao W, Spragg R, Smith RM. Inhibitory effect of porcine surfactant on the respiratory burst oxidase in human neutrophils. Attenuation of p47phox and p67phox membrane translocation as the mechanism. J Clin Invest. 1995 Dec; 96(6):2654-60. PMID: 8675631; PMCID: PMC185971.
      39. Gilliard N, Pappert D, Spragg R. Fractal analysis of surfactant deposition in rabbit lungs. J Appl Physiol (1985). 1995 Mar; 78(3):862-6. PMID: 7775330.
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      40. Gilliard N, Heldt GP, Loredo J, Gasser H, Redl H, Merritt TA, Spragg R. Exposure of the hydrophobic components of porcine lung surfactant to oxidant stress alters surface tension properties. J Clin Invest. 1994 Jun; 93(6):2608-15. PMID: 8200999; PMCID: PMC294496.
      41. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee. J Crit Care. 1994 Mar; 9(1):72-81. PMID: 8199655.
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      42. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994 Mar; 149(3 Pt 1):818-24. PMID: 7509706.
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      43. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med. 1994; 20(3):225-32. PMID: 8014293.
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      44. Spragg R, Gilliard N, Richman P, Smith RM, Hite RD, Pappert D, Robertson B, Curstedt T, Strayer D. Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome. Chest. 1994 Jan; 105(1):195-202. PMID: 8031347.
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      45. Spragg R. Making progress. Intensive Care Med. 1994; 20(1):4-5. PMID: 8163756.
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      46. Montisano DF, Mann T, Spragg R. H2O2 increases expression of pulmonary artery endothelial cell platelet-derived growth factor mRNA. J Appl Physiol (1985). 1992 Dec; 73(6):2255-62. PMID: 1490932.
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      47. Heldt GP, Merritt TA, Golembeski D, Gilliard N, Bloor C, Spragg R. Distribution of surfactant, lung compliance, and aeration of preterm rabbit lungs after surfactant therapy and conventional and high-frequency oscillatory ventilation. Pediatr Res. 1992 Mar; 31(3):270-5. PMID: 1561014.
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      48. Bozzette SA, Arcia J, Bartok AE, McGlynn LM, McCutchan JA, Richman DD, Spragg R, Spector SA. The impact of concomitant viral pathogens on the course of Pneumocystis carinii pneumonia. J Protozool. 1991 Nov-Dec; 38(6):183S-184S. PMID: 1667929.
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      49. Gilliard N, Pappert D, Merritt TA, Heldt G, Spragg R. Radiolabeling of the hydrophobic components of lung surfactant with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine. Anal Biochem. 1991 Mar 02; 193(2):310-5. PMID: 1872476.
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      50. Spragg R. DNA strand break formation following exposure of bovine pulmonary artery and aortic endothelial cells to reactive oxygen products. Am J Respir Cell Mol Biol. 1991 Jan; 4(1):4-10. PMID: 1846077.
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      51. Gilliard N, Richman PM, Merritt TA, Spragg R. Effect of volume and dose on the pulmonary distribution of exogenous surfactant administered to normal rabbits or to rabbits with oleic acid lung injury. Am Rev Respir Dis. 1990 Mar; 141(3):743-7. PMID: 2310102.
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      52. Smith RM, Traber LD, Traber DL, Spragg R. Pulmonary deposition and clearance of aerosolized alpha-1-proteinase inhibitor administered to dogs and to sheep. J Clin Invest. 1989 Oct; 84(4):1145-54. PMID: 2794051; PMCID: PMC329771.
      53. Richman PS, Spragg R, Robertson B, Merritt TA, Curstedt T. The adult respiratory distress syndrome: first trials with surfactant replacement. Eur Respir J Suppl. 1989 Mar; 3:109s-111s. PMID: 2742681.
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      54. Spragg R, Richman P, Gilliard N, Merritt TA, Robertson B, Curstedt T. The use of exogenous surfactant to treat patients with acute high-permeability lung edema. Prog Clin Biol Res. 1989; 308:791-6. PMID: 2675070.
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      55. Smith RM, Spragg R. Production and administration to dogs of aerosols of alpha-1-proteinase inhibitor. Am J Med. 1988 Jun 24; 84(6A):48-51. PMID: 3260073.
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      56. Moser KM, Smith RM, Spragg R, Tisi GM. Intravenous administration of alpha-1-proteinase inhibitor in patients of PiZ and PiM phenotype. Preliminary report. Am J Med. 1988 Jun 24; 84(6A):70-4. PMID: 3260074.
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      57. Schneiderman LJ, Spragg R. Ethical decisions in discontinuing mechanical ventilation. N Engl J Med. 1988 Apr 14; 318(15):984-8. PMID: 3352689.
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      58. Hyslop PA, Hinshaw DB, Halsey WA, Schraufstätter IU, Sauerheber RD, Spragg R, Jackson JH, Cochrane CG. Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J Biol Chem. 1988 Feb 05; 263(4):1665-75. PMID: 3338986.
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      59. Smith RM, Spragg R, Moser KM, Cochrane CG, McCarren JP. Pulmonary penetration of alpha 1-proteinase inhibitor administered parenterally to dogs. Am Rev Respir Dis. 1987 Dec; 136(6):1391-6. PMID: 3120632.
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      60. Spragg R, Schraufstatter IU, Hyslop PA, Hinshaw DB, Cochrane CG. Oxidant injury of cultured cells: biochemical consequences. Prog Clin Biol Res. 1987; 236A:253-8. PMID: 3112791.
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      61. Smith RM, Spragg R, Moser KM. Biologic availability of injected or aerosolized alpha 1 proteinase inhibitor. Prog Clin Biol Res. 1987; 236A:203-10. PMID: 3497405.
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      62. Hyslop PA, Hinshaw DB, Schraufstätter IU, Sklar LA, Spragg R, Cochrane CG. Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D1 cells. J Cell Physiol. 1986 Dec; 129(3):356-66. PMID: 3782310.
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      63. Schraufstatter IU, Hyslop PA, Hinshaw DB, Spragg R, Sklar LA, Cochrane CG. Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase. Proc Natl Acad Sci U S A. 1986 Jul; 83(13):4908-12. PMID: 2941760; PMCID: PMC323853.
      64. Hinshaw DB, Sklar LA, Bohl B, Schraufstatter IU, Hyslop PA, Rossi MW, Spragg R, Cochrane CG. Cytoskeletal and morphologic impact of cellular oxidant injury. Am J Pathol. 1986 Jun; 123(3):454-64. PMID: 3717299; PMCID: PMC1888261.
      65. Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg R, Cochrane CG. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest. 1986 Apr; 77(4):1312-20. PMID: 2937805; PMCID: PMC424485.
      66. Spragg R, Hinshaw DB, Hyslop PA, Schraufstätter IU, Cochrane CG. Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury. J Clin Invest. 1985 Oct; 76(4):1471-6. PMID: 2997279; PMCID: PMC424106.
      67. Bickler PE, Spragg R, Hartman MT, White FN. Distribution of ventilation in American alligator Alligator mississippiensis. Am J Physiol. 1985 Oct; 249(4 Pt 2):R477-81. PMID: 4051034.
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      68. Schraufstätter IU, Hinshaw DB, Hyslop PA, Spragg R, Cochrane CG. Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells. J Clin Invest. 1985 Sep; 76(3):1131-9. PMID: 3840176; PMCID: PMC424005.
      69. Krieger BP, Loomis WH, Czer GT, Spragg R. Mechanisms of interaction between oxygen and granulocytes in hyperoxic lung injury. J Appl Physiol (1985). 1985 Apr; 58(4):1326-30. PMID: 3838744.
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      70. Hallman M, Arjomaa P, Tahvanainen J, Lachmann B, Spragg R. Endobronchial surface active phospholipids in various pulmonary diseases. Eur J Respir Dis Suppl. 1985; 142:37-47. PMID: 3860395.
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      71. Lichter JP, Konopka RG, Hartman MT, Moser KM, Spragg R. The in vivo behavior of granulocytes labeled with indium-111 in a canine model of pneumococcal pneumonia. Am Rev Respir Dis. 1984 Apr; 129(4):602-6. PMID: 6712001.
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      72. Krieger B, Schwartz J, Loomis W, Marsh J, Spragg R. Nonspecificity of elevated angiotensin-converting enzyme activity in bronchoalveolar lavage fluid from high permeability lung edema states. Am Rev Respir Dis. 1984 Mar; 129(3):499-500. PMID: 6322628.
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      73. Krieger BP, Loomis WH, Spragg R. Granulocytes and hyperoxia act synergistically in causing acute lung injury. Exp Lung Res. 1984; 7(2):77-83. PMID: 6525983.
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      74. Schwartz JS, Konopka RG, Spragg R. Effect of histamine and propranolol on extravascular lung water. Am J Physiol. 1984 Jan; 246(1 Pt 2):H69-73. PMID: 6696090.
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      75. Moser KM, Spragg R, Utley J, Daily PO. Chronic thrombotic obstruction of major pulmonary arteries. Results of thromboendarterectomy in 15 patients. Ann Intern Med. 1983 Sep; 99(3):299-304. PMID: 6614679.
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      76. Spragg R, Wolf PL, Haghighi P, Abraham JL, Astarita RW. Angiosarcoma of the lung with fatal pulmonary hemorrhage. Am J Med. 1983 Jun; 74(6):1072-6. PMID: 6683073.
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      77. Cochrane CG, Spragg R, Revak SD, Schraufstatter I. Biochemical factors in pulmonary inflammatory disease. Chest. 1983 May; 83(5 Suppl):67S-70S. PMID: 6340987.
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      78. Cochrane CG, Spragg R, Revak SD. Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid. J Clin Invest. 1983 Mar; 71(3):754-61. PMID: 6600748; PMCID: PMC436926.
      79. Cochrane CG, Spragg R, Revak SD, Cohen AB, McGuire WW. The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Am Rev Respir Dis. 1983 Feb; 127(2):S25-7. PMID: 6550478.
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      80. Moser KM, Spragg R. Use of the balloon-tipped pulmonary artery catheter in pulmonary disease. Ann Intern Med. 1983 Jan; 98(1):53-8. PMID: 6848045.
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      81. Utley JR, Spragg R, Long WB, Moser KM. Pulmonary endarterectomy for chronic thromboembolic obstruction: recent surgical experience. Surgery. 1982 Dec; 92(6):1096-102. PMID: 7147187.
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      82. Spragg R, Benumof JL, Alfery DD. New methods for the performance of unilateral lung lavage. Anesthesiology. 1982 Dec; 57(6):535-8. PMID: 7149310.
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      83. Hooper WW, Slutsky RA, Kocienski DE, Witztum KF, Spragg R, Ashburn WL, Moser KM. Right and left ventricular response to subcutaneous terbutaline in patients with chronic obstructive pulmonary disease: radionuclide angiographic assessment of cardiac size and function. Am Heart J. 1982 Nov; 104(5 Pt 1):1027-32. PMID: 7136993.
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      84. McEvoy RD, Davies NJ, Hedenstierna G, Hartman MT, Spragg R, Wagner PD. Lung mucociliary transport during high-frequency ventilation. Am Rev Respir Dis. 1982 Sep; 126(3):452-6. PMID: 6751174.
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      85. Hallman M, Spragg R, Harrell JH, Moser KM, Gluck L. Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol. J Clin Invest. 1982 Sep; 70(3):673-83. PMID: 6896715; PMCID: PMC370271.
      86. Spragg R, Abraham JL, Loomis WH. Pulmonary platelet deposition accompanying acute oleic-acid-induced pulmonary injury. Am Rev Respir Dis. 1982 Sep; 126(3):553-7. PMID: 7125342.
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      87. Shure D, Spragg R, Moser KM. Large cavitary dead space as an unusual cause of hypercapnic respiratory failure in pulmonary tuberculosis. Thorax. 1982 Jul; 37(7):550-1. PMID: 7135301; PMCID: PMC459369.
      88. McGuire WW, Spragg R, Cohen AB, Cochrane CG. Studies on the pathogenesis of the adult respiratory distress syndrome. J Clin Invest. 1982 Mar; 69(3):543-53. PMID: 7037851; PMCID: PMC371010.
      89. Lane TA, Bergum PW, Lichter JP, Spragg R. The labeling of rabbit neutrophils with [111In]oxine. J Immunol Methods. 1982; 51(3):293-305. PMID: 6809833.
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      90. Moser KM, LeMoine JR, Nachtwey FJ, Spragg R. Deep venous thrombosis and pulmonary embolism. Frequency in a respiratory intensive care unit. JAMA. 1981 Sep 25; 246(13):1422-4. PMID: 7265445.
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      91. Moser KM, Spragg R, Bender F, Konopka R, Hartman MT, Fedullo P. Study of factors that may condition scintigraphic detection of venous thrombi and pulmonary emboli with indium-111-labeled platelets. J Nucl Med. 1980 Nov; 21(11):1051-8. PMID: 7431104.
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      92. Neuman TS, Spragg R, Wagner PD, Moser KM. Cardiopulmonary consequences of decompression stress. Respir Physiol. 1980 Aug; 41(2):143-53. PMID: 6776599.
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      93. Hill RN, Spragg R, Wedel MK, Moser KM. Letter: Adult respiratory distress syndrome associated with colchicine intoxication. Ann Intern Med. 1975 Oct; 83(4):523-4. PMID: 1166987.
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      94. Spragg R, Hill RN, Wedel MK, Materson A, Moser KM. Platelet kinetics in venovenous membrane oxygenation. Trans Am Soc Artif Intern Organs. 1975; 21:171-7. PMID: 1145990.
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      95. Hill RN, Shibel EM, Spragg R, Moser KM. Adult respiratory distress syndrome: early predictors of mortality. Trans Am Soc Artif Intern Organs. 1975; 21:199-205. PMID: 1145992.
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