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Bruce Zuraw

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0732
La Jolla CA 92093
Phone858-822-6597
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    Collapse Biography 
    Collapse Education and Training
    Loyola Stritch School of Medicine, Maywood, ILMD
    Carleton College, Northfield, MN,BA1972Biology

    Collapse Overview 
    Collapse Overview
    Dr. Zuraw is the Director of the US HAEA Angioedema Center at UC San Diego. Dr. Zuraw specializes in all types of non-histaminergic angioedemas.

    Research Interests
    - Allergic inflammation in humans with particular attention to hereditary angioedema
    - The mechanism of action of glucocorticoids


    Collapse Research 
    Collapse Research Activities and Funding
    Hereditary Angioedema(HAE)Conference
    NIH/NIAID R13AI110081Jan 8, 2014 - Dec 31, 2014
    Role: Principal Investigator
    Dual role of the bradykinin B2 receptor during inflammation
    VA I01BX000154Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    Airway inflammation and airway remodeling
    NIH/NIAID U19AI070535Jul 1, 2006 - Aug 31, 2021
    Role: Co-Investigator
    GILZ Controls TLR-Induced NF-kB Activity In Acute Asthma
    NIH/NIAID R01AI068086Jul 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    INITIATION AND PROPAGATION OF ASTHMATIC INFLAMMATION
    NIH/NIAID P01AI050498Sep 10, 2001 - Jun 30, 2007
    Role: Principal Investigator
    RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    NIH/NHLBI R01HL061003Jul 10, 1998 - Jun 30, 2004
    Role: Principal Investigator
    SIGNALING IN ALLERGIC INFLAMMATION
    NIH U19AI042244Sep 30, 1997 - Oct 15, 2001
    Role: Co-Investigator
    DISEASE VARIABLES IN HEREDITARY ANGIOEDEMA
    NIH/NIAID R01AI036220Mar 1, 1996 - Feb 28, 2002
    Role: Principal Investigator
    REGULATION OF C1 INHIBITOR SYNTHESIS AND CATABOLISM
    NIH/NHLBI R29HL039773Apr 1, 1988 - Mar 31, 1994
    Role: Principal Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH M01RR000833Dec 1, 1977 - Sep 30, 2005
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lara-Marquez ML, Christiansen SC, Riedl MA, Herschbach J, Zuraw B. Threshold-Stimulated Kallikrein Activity Distinguishes Bradykinin- From Histamine-Mediated Angioedema. Clin Exp Allergy. 2018 Jun 29. PMID: 29957871.
      View in: PubMed
    2. Banerji A, Li Y, Busse P, Riedl MA, Holtzman NS, Li HH, Davis-Lorton M, Bernstein JA, Frank M, Castaldo AJ, Long J, Zuraw B, Lumry W, Christiansen S. Hereditary angioedema from the patient's perspective: A follow-up patient survey. Allergy Asthma Proc. 2018 May 01; 39(3):212-223. PMID: 29669666.
      View in: PubMed
    3. Chen M, Kim A, Zuraw B, Doherty TA, Christiansen S. Mast cell disorders: Protean manifestations and treatment responses. Ann Allergy Asthma Immunol. 2018 Mar 28. PMID: 29604336.
      View in: PubMed
    4. Zuraw B. Hereditary angioedema with normal C1 inhibitor: Four types and counting. J Allergy Clin Immunol. 2018 Mar; 141(3):884-885. PMID: 29410040.
      View in: PubMed
    5. Lumry WR, Craig T, Zuraw B, Longhurst H, Baker J, Li HH, Bernstein JA, Anderson J, Riedl MA, Manning ME, Keith PK, Levy DS, Caballero T, Banerji A, Gower RG, Farkas H, Lawo JP, Pragst I, Machnig T, Watson DJ. Health-Related Quality of Life with Subcutaneous C1-Inhibitor for Prevention of Attacks of Hereditary Angioedema. J Allergy Clin Immunol Pract. 2018 Jan 31. PMID: 29391286.
      View in: PubMed
    6. Maurer M, Magerl M, Ansotegui I, Aygören-Pürsün E, Betschel S, Bork K, Bowen T, Balle Boysen H, Farkas H, Grumach AS, Hide M, Katelaris C, Lockey R, Longhurst H, Lumry WR, Martinez-Saguer I, Moldovan D, Nast A, Pawankar R, Potter P, Riedl M, Ritchie B, Rosenwasser L, Sánchez-Borges M, Zhi Y, Zuraw B, Craig T. The international WAO/EAACI guideline for the management of hereditary angioedema-The 2017 revision and update. Allergy. 2018 Jan 10. PMID: 29318628.
      View in: PubMed
    7. Zhang Y, Tortorici MA, Pawaskar D, Pragst I, Machnig T, Hutmacher M, Zuraw B, Cicardi M, Craig T, Longhurst H, Sidhu J. Exposure-Response Model of Subcutaneous C1-Inhibitor Concentrate to Estimate the Risk of Attacks in Patients With Hereditary Angioedema. CPT Pharmacometrics Syst Pharmacol. 2018 Mar; 7(3):158-165. PMID: 29316335.
      View in: PubMed
    8. Christiansen SC, Zuraw B. Laboratory Approaches for Assessing Contact System Activation. Immunol Allergy Clin North Am. 2017 08; 37(3):527-539. PMID: 28687107.
      View in: PubMed
    9. Longhurst H, Cicardi M, Craig T, Bork K, Grattan C, Baker J, Li HH, Reshef A, Bonner J, Bernstein JA, Anderson J, Lumry WR, Farkas H, Katelaris CH, Sussman GL, Jacobs J, Riedl M, Manning ME, Hebert J, Keith PK, Kivity S, Neri S, Levy DS, Baeza ML, Nathan R, Schwartz LB, Caballero T, Yang W, Crisan I, Hernandez MD, Hussain I, Tarzi M, Ritchie B, Králícková P, Guilarte M, Rehman SM, Banerji A, Gower RG, Bensen-Kennedy D, Edelman J, Feuersenger H, Lawo JP, Machnig T, Pawaskar D, Pragst I, Zuraw B. Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor. N Engl J Med. 2017 03 23; 376(12):1131-1140. PMID: 28328347.
      View in: PubMed
    10. Tse KY, Zuraw B, Chen Q, Christiansen SC. Anabolic androgen use in the management of hereditary angioedema: Not so cheap after all. Ann Allergy Asthma Immunol. 2017 04; 118(4):456-460.e1. PMID: 28283277.
      View in: PubMed
    11. Eastman JJ, Cavagnero KJ, Deconde AS, Kim AS, Karta MR, Broide DH, Zuraw B, White AA, Christiansen SC, Doherty TA. Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2017 Jul; 140(1):101-108.e3. PMID: 28279492.
      View in: PubMed
    12. Otani IM, Lumry WR, Hurwitz S, Li HH, Craig TJ, Holtzman NS, Iandoli MI, Tucker J, Riedl MA, Zuraw B, Banerji A. Subcutaneous Icatibant for the Treatment of Hereditary Angioedema Attacks: Comparison of Home Self-Administration with Administration at a Medical Facility. J Allergy Clin Immunol Pract. 2017 Mar - Apr; 5(2):442-447.e1. PMID: 27818136.
      View in: PubMed
    13. Frank MM, Zuraw B, Banerji A, Bernstein JA, Craig T, Busse P, Christiansen S, Davis-Lorton M, Li HH, Lumry WR, Riedl M. Management of Children With Hereditary Angioedema Due to C1 Inhibitor Deficiency. Pediatrics. 2016 Nov; 138(5). PMID: 27940765.
      View in: PubMed
    14. Zuraw B, Christiansen SC. HAE Pathophysiology and Underlying Mechanisms. Clin Rev Allergy Immunol. 2016 Oct; 51(2):216-29. PMID: 27459852.
      View in: PubMed
    15. Otani IM, Christiansen SC, Busse P, Camargo CA, Zuraw B, Riedl MA, Banerji A. Emergency Department Management of Hereditary Angioedema Attacks: Patient Perspectives. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):128-134.e4. PMID: 27665386.
      View in: PubMed
    16. Zuraw B, Davis DK, Castaldo AJ, Christiansen SC. Tolerability and Effectiveness of 17-a-Alkylated Androgen Therapy for Hereditary Angioedema: A Re-examination. J Allergy Clin Immunol Pract. 2016 Sep-Oct; 4(5):948-955.e15. PMID: 27329469.
      View in: PubMed
    17. Hofman ZL, Relan A, Zeerleder S, Drouet C, Zuraw B, Hack CE. Angioedema attacks in patients with hereditary angioedema: Local manifestations of a systemic activation process. J Allergy Clin Immunol. 2016 Aug; 138(2):359-66. PMID: 27246526.
      View in: PubMed
    18. Doshi A, Tse K, Riedl M, Zuraw B, Christiansen S. Cases of acquired C1 inhibitor deficiency treated with rituximab. J Allergy Clin Immunol Pract. 2016 Sep-Oct; 4(5):987-8. PMID: 27130715.
      View in: PubMed
    19. Miller M, Esnault S, Kurten RC, Kelly EA, Beppu A, Das S, Rosenthal P, Ramsdell J, Croft M, Zuraw B, Jarjour N, Hamid Q, Broide DH. Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma. J Allergy Clin Immunol. 2016 Aug; 138(2):596-599.e4. PMID: 27001159; PMCID: PMC4975994 [Available on 08/01/17].
    20. Zuraw B, Christiansen SC. How we manage persons with hereditary angioedema. Br J Haematol. 2016 06; 173(6):831-43. PMID: 27071490.
      View in: PubMed
    21. Eastman J, Zuraw B. Angioedema due to allergy in a patient with hereditary angioedema: all that glitters is not gold. Ann Allergy Asthma Immunol. 2016 Apr; 116(4):376. PMID: 26916444.
      View in: PubMed
    22. Christiansen SC, Davis DK, Castaldo AJ, Zuraw B. Pediatric Hereditary Angioedema: Onset, Diagnostic Delay, and Disease Severity. Clin Pediatr (Phila). 2016 Sep; 55(10):935-42. PMID: 26581355.
      View in: PubMed
    23. Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, Song DJ, Vuong C, Doherty T, Croft M, Zuraw B, Zhang X, Gao X, Aceves S, Chouiali F, Hamid Q, Broide DH. Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol. 2015 Oct 15; 195(8):3546-56. PMID: 26355153; PMCID: PMC4811198 [Available on 10/15/16].
    24. Christiansen SC, Schatz M, Yang SJ, Ngor E, Chen W, Zuraw B. Hypertension and Asthma: A Comorbid Relationship. J Allergy Clin Immunol Pract. 2016 Jan-Feb; 4(1):76-81. PMID: 26342745.
      View in: PubMed
    25. Craig T, Pürsün EA, Bork K, Bowen T, Boysen H, Farkas H, Grumach A, Katelaris CH, Lockey R, Longhurst H, Lumry W, Magerl M, Martinez-Saguer I, Ritchie B, Nast A, Pawankar R, Zuraw B, Maurer M. [WAO Guideline for the Management of Hereditary Angioedema]. Arerugi. 2015 Sep; 64(9):1215-41. PMID: 26657910.
      View in: PubMed
    26. Zuraw B, Cicardi M, Longhurst HJ, Bernstein JA, Li HH, Magerl M, Martinez-Saguer I, Rehman SM, Staubach P, Feuersenger H, Parasrampuria R, Sidhu J, Edelman J, Craig T. Phase II study results of a replacement therapy for hereditary angioedema with subcutaneous C1-inhibitor concentrate. Allergy. 2015 Oct; 70(10):1319-28. PMID: 26016741; PMCID: PMC4755045.
    27. Bonner N, Abetz-Webb L, Renault L, Caballero T, Longhurst H, Maurer M, Christiansen S, Zuraw B. Development and content validity testing of a patient-reported outcomes questionnaire for the assessment of hereditary angioedema in observational studies. Health Qual Life Outcomes. 2015 Jul 01; 13:92. PMID: 26129930; PMCID: PMC4487558.
    28. Mehta AK, Duan W, Doerner AM, Traves SL, Broide DH, Proud D, Zuraw B, Croft M. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33. J Allergy Clin Immunol. 2016 Jan; 137(1):278-288.e6. PMID: 26100084; PMCID: PMC4684822 [Available on 01/01/17].
    29. Banerji A, Busse P, Christiansen SC, Li H, Lumry W, Davis-Lorton M, Bernstein JA, Frank M, Castaldo A, Long JF, Zuraw B, Riedl M. Current state of hereditary angioedema management: a patient survey. Allergy Asthma Proc. 2015 May-Jun; 36(3):213-7. PMID: 25976438; PMCID: PMC4405601.
    30. Tse K, Chen L, Tse M, Zuraw B, Christiansen S. Effect of catastrophic wildfires on asthmatic outcomes in obese children: breathing fire. Ann Allergy Asthma Immunol. 2015 Apr; 114(4):308-311.e4. PMID: 25747784; PMCID: PMC4387007.
    31. Christiansen SC, Bygum A, Banerji A, Busse P, Li H, Lumry W, Davis-Lorton M, Bernstein JA, Frank MM, Castaldo A, Long JF, Riedl M, Zuraw B. Before and after, the impact of available on-demand treatment for HAE. Allergy Asthma Proc. 2015 Mar-Apr; 36(2):145-50. PMID: 25715243.
      View in: PubMed
    32. Betschel S, Badiou J, Binkley K, Hébert J, Kanani A, Keith P, Lacuesta G, Yang B, Aygören-Pürsün E, Bernstein J, Bork K, Caballero T, Cicardi M, Craig T, Farkas H, Longhurst H, Zuraw B, Boysen H, Borici-Mazi R, Bowen T, Dallas K, Dean J, Lang-Robertson K, Laramée B, Leith E, Mace S, McCusker C, Moote B, Poon MC, Ritchie B, Stark D, Sussman G, Waserman S. Canadian hereditary angioedema guideline. Allergy Asthma Clin Immunol. 2014; 10(1):50. PMID: 25352908; PMCID: PMC4210625.
    33. Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, Sheikh J, Weldon D, Zuraw B, Bernstein DI, Blessing-Moore J, Cox L, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CR, Schuller DE, Spector SL, Tilles SA, Wallace D. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014 May; 133(5):1270-7. PMID: 24766875.
      View in: PubMed
    34. Moellman JJ, Bernstein JA, Lindsell C, Banerji A, Busse PJ, Camargo CA, Collins SP, Craig TJ, Lumry WR, Nowak R, Pines JM, Raja AS, Riedl M, Ward MJ, Zuraw B, Diercks D, Hiestand B, Campbell RL, Schneider S, Sinert R. A consensus parameter for the evaluation and management of angioedema in the emergency department. Acad Emerg Med. 2014 Apr; 21(4):469-84. PMID: 24730413; PMCID: PMC4100605.
    35. Cicardi M, Aberer W, Banerji A, Bas M, Bernstein JA, Bork K, Caballero T, Farkas H, Grumach A, Kaplan AP, Riedl MA, Triggiani M, Zanichelli A, Zuraw B. Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group. Allergy. 2014 May; 69(5):602-16. PMID: 24673465.
      View in: PubMed
    36. Walford HH, Zuraw B. Current update on cellular and molecular mechanisms of hereditary angioedema. Ann Allergy Asthma Immunol. 2014 May; 112(5):413-8. PMID: 24484972.
      View in: PubMed
    37. Zuraw B. Immunology and Allergy Clinics of North America. Angioedema. Preface. Immunol Allergy Clin North Am. 2013 Nov; 33(4):xi-xiii. PMID: 24176220.
      View in: PubMed
    38. Zuraw B, Banerji A, Bernstein JA, Busse PJ, Christiansen SC, Davis-Lorton M, Frank MM, Li HH, Lumry WR, Riedl M. US Hereditary Angioedema Association Medical Advisory Board 2013 recommendations for the management of hereditary angioedema due to C1 inhibitor deficiency. J Allergy Clin Immunol Pract. 2013 Sep-Oct; 1(5):458-67. PMID: 24565617.
      View in: PubMed
    39. Zuraw B, Christiansen SC. Rare disease partnership: the role of the US HAEA in angioedema care. Immunol Allergy Clin North Am. 2013 Nov; 33(4):545-53. PMID: 24176218.
      View in: PubMed
    40. Zuraw B, Bernstein JA, Lang DM, Craig T, Dreyfus D, Hsieh F, Khan D, Sheikh J, Weldon D, Bernstein DI, Blessing-Moore J, Cox L, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CR, Schuller DE, Spector SL, Tilles SA, Wallace D. A focused parameter update: hereditary angioedema, acquired C1 inhibitor deficiency, and angiotensin-converting enzyme inhibitor-associated angioedema. J Allergy Clin Immunol. 2013 Jun; 131(6):1491-3. PMID: 23726531.
      View in: PubMed
    41. Tse K, Zuraw B. Recognizing and managing hereditary angioedema. Cleve Clin J Med. 2013 May; 80(5):297-308. PMID: 23636922.
      View in: PubMed
    42. Riedl MA, Levy RJ, Suez D, Lockey RF, Baker JW, Relan A, Zuraw B. Efficacy and safety of recombinant C1 inhibitor for the treatment of hereditary angioedema attacks: a North American open-label study. Ann Allergy Asthma Immunol. 2013 Apr; 110(4):295-9. PMID: 23535096.
      View in: PubMed
    43. Lang DM, Aberer W, Bernstein JA, Chng HH, Grumach AS, Hide M, Maurer M, Weber R, Zuraw B. International consensus on hereditary and acquired angioedema. Ann Allergy Asthma Immunol. 2012 Dec; 109(6):395-402. PMID: 23176876.
      View in: PubMed
    44. Craig T, Aygören-Pürsün E, Bork K, Bowen T, Boysen H, Farkas H, Grumach A, Katelaris CH, Lockey R, Longhurst H, Lumry W, Magerl M, Martinez-Saguer I, Ritchie B, Nast A, Pawankar R, Zuraw B, Maurer M. WAO Guideline for the Management of Hereditary Angioedema. World Allergy Organ J. 2012 Dec; 5(12):182-99. PMID: 23282420; PMCID: PMC3651186.
    45. Zuraw B, Bork K, Binkley KE, Banerji A, Christiansen SC, Castaldo A, Kaplan A, Riedl M, Kirkpatrick C, Magerl M, Drouet C, Cicardi M. Hereditary angioedema with normal C1 inhibitor function: consensus of an international expert panel. Allergy Asthma Proc. 2012 Nov-Dec; 33 Suppl 1:S145-56. PMID: 23394603.
      View in: PubMed
    46. Zuraw B, Kalfus I. Safety and efficacy of prophylactic nanofiltered C1-inhibitor in hereditary angioedema. Am J Med. 2012 Sep; 125(9):938.e1-7. PMID: 22800873.
      View in: PubMed
    47. Kusuma A, Relan A, Knulst AC, Moldovan D, Zuraw B, Cicardi M, Levy RJ, Nuijens JH, Hack CE. Clinical impact of peripheral attacks in hereditary angioedema patients. Am J Med. 2012 Sep; 125(9):937.e17-24. PMID: 22748405.
      View in: PubMed
    48. Kelly MM, King EM, Rider CF, Gwozd C, Holden NS, Eddleston J, Zuraw B, Leigh R, O'Byrne PM, Newton R. Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. Br J Pharmacol. 2012 Mar; 165(6):1737-1747. PMID: 21827450; PMCID: PMC3372826.
    49. Cicardi M, Bork K, Caballero T, Craig T, Li HH, Longhurst H, Reshef A, Zuraw B. Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group. Allergy. 2012 Feb; 67(2):147-57. PMID: 22126399.
      View in: PubMed
    50. Tourangeau LM, Castaldo AJ, Davis DK, Koziol J, Christiansen SC, Zuraw B. Safety and efficacy of physician-supervised self-managed C1 inhibitor replacement therapy. Int Arch Allergy Immunol. 2012; 157(4):417-24. PMID: 22123229; PMCID: PMC3242706.
    51. Zuraw B, Christiansen SC. Pathophysiology of hereditary angioedema. Am J Rhinol Allergy. 2011 Nov-Dec; 25(6):373-8. PMID: 22185738.
      View in: PubMed
    52. Christiansen SC, Zuraw B. Hereditary angioedema: management of laryngeal attacks. Am J Rhinol Allergy. 2011 Nov-Dec; 25(6):379-82. PMID: 22185739.
      View in: PubMed
    53. Tourangeau LM, Zuraw B. The new era of C1-esterase inhibitor deficiency therapy. Curr Allergy Asthma Rep. 2011 Oct; 11(5):345-51. PMID: 21833753.
      View in: PubMed
    54. Carr WW, Bernstein DI, Hampel FC, Gow JA, Williams JI, Zuraw B, Chipps BE, Miller TA, Berger WE, Carr WW, Tort MJ. Abstracts from the North American Rhinology & Allergy Conference, February 3, 2011, Puerto Rico. Am J Rhinol Allergy. 2011 Sep 01; 25(5):369. PMID: 29021069.
      View in: PubMed
    55. Quinto KB, Zuraw B, Poon KY, Chen W, Schatz M, Christiansen SC. The association of obesity and asthma severity and control in children. J Allergy Clin Immunol. 2011 Nov; 128(5):964-9. PMID: 21820711.
      View in: PubMed
    56. Doherty TA, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho JY, Norris PS, Choi H, Scheu S, Pfeffer K, Zuraw B, Ware CF, Broide DH, Croft M. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med. 2011 May; 17(5):596-603. PMID: 21499267; PMCID: PMC3097134.
    57. Zuraw B, Cicardi M, Levy RJ, Nuijens JH, Relan A, Visscher S, Haase G, Kaufman L, Hack CE. Recombinant human C1-inhibitor for the treatment of acute angioedema attacks in patients with hereditary angioedema. J Allergy Clin Immunol. 2010 Oct; 126(4):821-827.e14. PMID: 20920772.
      View in: PubMed
    58. Zuraw B, Frank MM, Riedl MA. Introduction: New Perspectives in Hereditary Angioedema (HAE): Molecular Mechanisms & Therapeutic Choices: A CME Symposium Presented at the 2009 World Allergy Congress, Buenos Aires, Argentina, December 9, 2009. World Allergy Organ J. 2010 Sep; 3(9 Suppl):S24. PMID: 23282865; PMCID: PMC3666148.
    59. Zuraw B. Summary and Conclusions: New Perspectives in Hereditary Angioedema: Molecular Mechanisms and Therapeutic Choices: A CME Symposium Presented at the World Allergy Congress, Buenos Aires, Argentina (December 2009). World Allergy Organ J. 2010 Sep; 3(9 Suppl):S39-40. PMID: 23282869; PMCID: PMC3666150.
    60. Zuraw B. The pathophysiology of hereditary angioedema. World Allergy Organ J. 2010 Sep; 3(9 Suppl):S25-8. PMID: 23282866; PMCID: PMC3666152.
    61. Zuraw B, Busse PJ, White M, Jacobs J, Lumry W, Baker J, Craig T, Grant JA, Hurewitz D, Bielory L, Cartwright WE, Koleilat M, Ryan W, Schaefer O, Manning M, Patel P, Bernstein JA, Friedman RA, Wilkinson R, Tanner D, Kohler G, Gunther G, Levy R, McClellan J, Redhead J, Guss D, Heyman E, Blumenstein BA, Kalfus I, Frank MM. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. N Engl J Med. 2010 Aug 05; 363(6):513-22. PMID: 20818886.
      View in: PubMed
    62. Zuraw B. HAE therapies: past present and future. Allergy Asthma Clin Immunol. 2010 Jul 28; 6(1):23. PMID: 20667126; PMCID: PMC2921104.
    63. Bowen T, Cicardi M, Farkas H, Bork K, Longhurst HJ, Zuraw B, Aygoeren-Pürsün E, Craig T, Binkley K, Hebert J, Ritchie B, Bouillet L, Betschel S, Cogar D, Dean J, Devaraj R, Hamed A, Kamra P, Keith PK, Lacuesta G, Leith E, Lyons H, Mace S, Mako B, Neurath D, Poon MC, Rivard GE, Schellenberg R, Rowan D, Rowe A, Stark D, Sur S, Tsai E, Warrington R, Waserman S, Ameratunga R, Bernstein J, Björkander J, Brosz K, Brosz J, Bygum A, Caballero T, Frank M, Fust G, Harmat G, Kanani A, Kreuz W, Levi M, Li H, Martinez-Saguer I, Moldovan D, Nagy I, Nielsen EW, Nordenfelt P, Reshef A, Rusicke E, Smith-Foltz S, Späth P, Varga L, Xiang ZY. 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol. 2010 Jul 28; 6(1):24. PMID: 20667127; PMCID: PMC2921362.
    64. Longhurst HJ, Farkas H, Craig T, Aygören-Pürsün E, Bethune C, Bjorkander J, Bork K, Bouillet L, Boysen H, Bygum A, Caballero T, Cicardi M, Dempster J, Gompels M, Gooi J, Grigoriadou S, Huffer U, Kreuz W, Levi MM, Long J, Martinez-Saguer I, Raguet M, Reshef A, Bowen T, Zuraw B. HAE international home therapy consensus document. Allergy Asthma Clin Immunol. 2010 Jul 28; 6(1):22. PMID: 20667125; PMCID: PMC2922091.
    65. Eddleston J, Lee RU, Doerner AM, Herschbach J, Zuraw B. Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection. Am J Respir Cell Mol Biol. 2011 Jan; 44(1):118-26. PMID: 20224072; PMCID: PMC3028255.
    66. Zuraw B, Yasothan U, Kirkpatrick P. Ecallantide. Nat Rev Drug Discov. 2010 Mar; 9(3):189-90. PMID: 20190785.
      View in: PubMed
    67. Doerner AM, Zuraw B. TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids. Respir Res. 2009 Oct 27; 10:100. PMID: 19857272; PMCID: PMC2774671.
    68. Zuraw B, Christiansen SC. Pathogenesis and laboratory diagnosis of hereditary angioedema. Allergy Asthma Proc. 2009 Sep-Oct; 30(5):487-92. PMID: 19843402.
      View in: PubMed
    69. Christiansen SC, Zuraw B. Update on therapeutic developments for hereditary angioedema. Allergy Asthma Proc. 2009 Sep-Oct; 30(5):500-5. PMID: 19843404.
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    70. Sexton DJ, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, Nixon AE, Zuraw B, Forteza RM, Abraham WM, Wood CR. Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. Biochem J. 2009 Aug 13; 422(2):383-92. PMID: 19527222.
      View in: PubMed
    71. Mukherjee S, Chen LY, Papadimos TJ, Huang S, Zuraw B, Pan ZK. Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM. J Biol Chem. 2009 Oct 23; 284(43):29391-8. PMID: 19638630; PMCID: PMC2785571.
    72. Bengtson SH, Eddleston J, Mörgelin M, Zuraw B, Herwald H. Regulation of kinin B(2) receptors by bradykinin in human lung cells. Biol Chem. 2008 Nov; 389(11):1435-40. PMID: 18783336.
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    75. Kiemer AK, Senaratne RH, Hoppstädter J, Diesel B, Riley LW, Tabeta K, Bauer S, Beutler B, Zuraw B. Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. J Innate Immun. 2009; 1(1):29-45. PMID: 20375564.
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    76. Zuraw B, Christiansen SC. New promise and hope for treating hereditary angioedema. Expert Opin Investig Drugs. 2008 May; 17(5):697-706. PMID: 18447596.
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    78. Bowen T, Cicardi M, Bork K, Zuraw B, Frank M, Ritchie B, Farkas H, Varga L, Zingale LC, Binkley K, Wagner E, Adomaitis P, Brosz K, Burnham J, Warrington R, Kalicinsky C, Mace S, McCusker C, Schellenberg R, Celeste L, Hebert J, Valentine K, Poon MC, Serushago B, Neurath D, Yang W, Lacuesta G, Issekutz A, Hamed A, Kamra P, Dean J, Kanani A, Stark D, Rivard GE, Leith E, Tsai E, Waserman S, Keith PK, Page D, Marchesin S, Longhurst HJ, Kreuz W, Rusicke E, Martinez-Saguer I, Aygören-Pürsün E, Harmat G, Füst G, Li H, Bouillet L, Caballero T, Moldovan D, Späth PJ, Smith-Foltz S, Nagy I, Nielsen EW, Bucher C, Nordenfelt P, Xiang ZY. Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Ann Allergy Asthma Immunol. 2008 Jan; 100(1 Suppl 2):S30-40. PMID: 18220150.
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    79. Rao SP, Wang Z, Zuberi RI, Sikora L, Bahaie NS, Zuraw B, Liu FT, Sriramarao P. Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow. J Immunol. 2007 Dec 01; 179(11):7800-7. PMID: 18025226.
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    80. Bengtson SH, Eddleston J, Christiansen SC, Zuraw B. Double-stranded RNA increases kinin B1 receptor expression and function in human airway epithelial cells. Int Immunopharmacol. 2007 Dec 20; 7(14):1880-7. PMID: 18039525.
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    81. Zuraw B. Novel therapies for hereditary angioedema. Immunol Allergy Clin North Am. 2006 Nov; 26(4):691-708. PMID: 17085285.
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    82. Eddleston J, Herschbach J, Wagelie-Steffen AL, Christiansen SC, Zuraw B. The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells. J Allergy Clin Immunol. 2007 Jan; 119(1):115-22. PMID: 17208592.
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    83. Bengtson SH, Phagoo SB, Norrby-Teglund A, Påhlman L, Mörgelin M, Zuraw B, Leeb-Lundberg LM, Herwald H. Kinin receptor expression during Staphylococcus aureus infection. Blood. 2006 Sep 15; 108(6):2055-63. PMID: 16735595; PMCID: PMC1895540.
    84. DiScipio RG, Schraufstatter IU, Sikora L, Zuraw B, Sriramarao P. C5a mediates secretion and activation of matrix metalloproteinase 9 from human eosinophils and neutrophils. Int Immunopharmacol. 2006 Jul; 6(7):1109-18. PMID: 16714214.
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    85. Leeb-Lundberg LM, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw B. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar; 57(1):27-77. PMID: 15734727.
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    86. Zuraw B. Current and future therapy for hereditary angioedema. Clin Immunol. 2005 Jan; 114(1):10-6. PMID: 15596404.
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    87. Kollmeier AP, Eddleston J, Zuraw B, Christiansen SC. Recurrent anaphylaxis linked to pantoprazole. J Allergy Clin Immunol. 2004 Oct; 114(4):975-7. PMID: 15480345.
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    88. Bowen T, Cicardi M, Farkas H, Bork K, Kreuz W, Zingale L, Varga L, Martinez-Saguer I, Aygören-Pürsün E, Binkley K, Zuraw B, Davis A, Hebert J, Ritchie B, Burnham J, Castaldo A, Menendez A, Nagy I, Harmat G, Bucher C, Lacuesta G, Issekutz A, Warrington R, Yang W, Dean J, Kanani A, Stark D, McCusker C, Wagner E, Rivard GE, Leith E, Tsai E, MacSween M, Lyanga J, Serushago B, Leznoff A, Waserman S, de Serres J. Canadian 2003 International Consensus Algorithm For the Diagnosis, Therapy, and Management of Hereditary Angioedema. J Allergy Clin Immunol. 2004 Sep; 114(3):629-37. PMID: 15356569.
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    89. Zuraw B. Diagnosis and management of hereditary angioedema: an American approach. Transfus Apher Sci. 2003 Dec; 29(3):239-45. PMID: 14572816.
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    90. Chen LY, Zuraw B, Ye RD, Pan ZK. A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes. J Biol Chem. 2004 Feb 20; 279(8):7208-12. PMID: 14660653.
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    91. Dosanjh A, Zuraw B. Endothelin-1 (ET-1) decreases human bronchial epithelial cell migration and proliferation: implications for airway remodeling in asthma. J Asthma. 2003 Dec; 40(8):883-6. PMID: 14736087.
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    92. Stevenson DD, Zuraw B. Pathogenesis of aspirin-exacerbated respiratory disease. Clin Rev Allergy Immunol. 2003 Apr; 24(2):169-88. PMID: 12668897.
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    93. Eddleston J, Christiansen SC, Jenkins GR, Koziol JA, Zuraw B. Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic rhinitis. J Allergy Clin Immunol. 2003 Jan; 111(1):106-12. PMID: 12532104.
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    94. Chen LY, Zuraw B, Zhao M, Liu FT, Huang S, Pan ZK. Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytes. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L607-13. PMID: 12495941.
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    95. Eddleston J, Christiansen SC, Zuraw B. Functional expression of the C-X-C chemokine receptor CXCR4 by human bronchial epithelial cells: regulation by proinflammatory mediators. J Immunol. 2002 Dec 01; 169(11):6445-51. PMID: 12444153.
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    96. Chen LY, Zuraw B, Liu FT, Huang S, Pan ZK. IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription. J Immunol. 2002 Oct 01; 169(7):3934-9. PMID: 12244193.
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    97. Christiansen SC, Zuraw B. Serving the underserved: school-based asthma intervention programs. J Asthma. 2002 Sep; 39(6):463-72. PMID: 12375704.
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    98. Christiansen SC, Eddleston J, Woessner KM, Chambers SS, Ye R, Pan ZK, Zuraw B. Up-regulation of functional kinin B1 receptors in allergic airway inflammation. J Immunol. 2002 Aug 15; 169(4):2054-60. PMID: 12165532.
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    99. Koziol JA, Zuraw B, Christiansen SC. Health care consumption among elderly patients in california: a comprehensive 10-year evaluation of trends in hospitalization rates and charges. Gerontologist. 2002 Apr; 42(2):207-16. PMID: 11914464.
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    100. Kuwabara I, Kuwabara Y, Yang RY, Schuler M, Green DR, Zuraw B, Hsu DK, Liu FT. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem. 2002 Feb 01; 277(5):3487-97. PMID: 11706006.
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    101. Zuraw B. Bradykinin in protection against left-ventricular hypertrophy. Lancet. 2001 Oct 06; 358(9288):1116-8. PMID: 11597662.
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    102. Huang S, Chen LY, Zuraw B, Ye RD, Pan ZK. Chemoattractant-stimulated NF-kappaB activation is dependent on the low molecular weight GTPase RhoA. J Biol Chem. 2001 Nov 02; 276(44):40977-81. PMID: 11533055.
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    103. Zuraw B, Herschbach J. Detection of C1 inhibitor mutations in patients with hereditary angioedema. J Allergy Clin Immunol. 2000 Mar; 105(3):541-6. PMID: 10719305.
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    104. Pan ZK, Chen LY, Cochrane CG, Zuraw B. fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes: the role of phosphatidylinositol 3-kinase. J Immunol. 2000 Jan 01; 164(1):404-11. PMID: 10605036.
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    105. Jagels MA, Daffern PJ, Zuraw B, Hugli TE. Mechanisms and regulation of polymorphonuclear leukocyte and eosinophil adherence to human airway epithelial cells. Am J Respir Cell Mol Biol. 1999 Sep; 21(3):418-27. PMID: 10460760.
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    106. Pan ZK, Christiansen SC, Ptasznik A, Zuraw B. Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kappaB activation in cultured human epithelial cells. J Biol Chem. 1999 Apr 09; 274(15):9918-22. PMID: 10187765.
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    107. Lung CC, Jagels MA, Daffern PJ, Tan EM, Zuraw B. Induction of human B2 bradykinin receptor mRNA and membrane receptors by IFNgamma. Immunopharmacology. 1998 Jun; 39(3):243-53. PMID: 9754910.
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    108. Pan ZK, Ye RD, Christiansen SC, Jagels MA, Bokoch GM, Zuraw B. Role of the Rho GTPase in bradykinin-stimulated nuclear factor-kappaB activation and IL-1beta gene expression in cultured human epithelial cells. J Immunol. 1998 Mar 15; 160(6):3038-45. PMID: 9510209.
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    109. Christiansen SC, Martin SB, Schleicher NC, Koziol JA, Mathews KP, Zuraw B. Evaluation of a school-based asthma education program for inner-city children. J Allergy Clin Immunol. 1997 Nov; 100(5):613-7. PMID: 9389290.
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    110. Zuraw B. Urticaria, angioedema, and autoimmunity. Clin Lab Med. 1997 Sep; 17(3):559-69. PMID: 9316773.
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    111. Lung CC, Chan EK, Zuraw B. Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency. J Allergy Clin Immunol. 1997 Jan; 99(1 Pt 1):134-46. PMID: 9003221.
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    112. Pan ZK, Zuraw B, Lung CC, Prossnitz ER, Browning DD, Ye RD. Bradykinin stimulates NF-kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts. J Clin Invest. 1996 Nov 01; 98(9):2042-9. PMID: 8903323; PMCID: PMC507648.
    113. Christiansen SC, Martin SB, Schleicher NC, Koziol JA, Hamilton RG, Zuraw B. Exposure and sensitization to environmental allergen of predominantly Hispanic children with asthma in San Diego's inner city. J Allergy Clin Immunol. 1996 Aug; 98(2):288-94. PMID: 8757205.
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    114. Lung CC, Chan EK, Zuraw B. Exon 1 sequence of the human B2 bradykinin receptor gene and its transcript. Immunopharmacology. 1996 Jun; 33(1-3):90-2. PMID: 8856121.
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    115. Christiansen SC, Martin SB, Schleicher NC, Koziol JA, Mathews KP, Zuraw B. Current prevalence of asthma-related symptoms in San Diego's predominantly Hispanic inner-city children. J Asthma. 1996; 33(1):17-26. PMID: 8621367.
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    116. Mathews KP, Konstantinov KN, Kuwabara I, Hill PN, Hsu DK, Zuraw B, Liu FT. Evidence for IgG autoantibodies to galectin-3, a beta-galactoside-binding lectin (Mac-2, epsilon binding protein, or carbohydrate binding protein 35) in human serum. J Clin Immunol. 1995 Nov; 15(6):329-37. PMID: 8576319.
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    117. Juergens UR, Christiansen SC, Stevenson DD, Zuraw B. Inhibition of monocyte leukotriene B4 production after aspirin desensitization. J Allergy Clin Immunol. 1995 Aug; 96(2):148-56. PMID: 7636051.
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    118. Mathews KP, Herschbach JH, Chambers SL, Zuraw B. Improved method for measuring C1-r-C1-s-(C1 inh)2 complexes by an enzyme-linked immunosorbent assay. J Clin Lab Anal. 1995; 9(3):196-203. PMID: 7602428.
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    119. Lotz M, Villiger P, Hugli T, Koziol J, Zuraw B. Interleukin-6 and interstitial cystitis. J Urol. 1994 Sep; 152(3):869-73. PMID: 8051739.
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    120. Zuraw B, Sugimoto S, Parsons CL, Hugli T, Lotz M, Koziol J. Activation of urinary kallikrein in patients with interstitial cystitis. J Urol. 1994 Sep; 152(3):874-8. PMID: 8051740.
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    121. Juergens UR, Christiansen SC, Stevenson DD, Zuraw B. Arachidonic acid metabolism in monocytes of aspirin-sensitive asthmatic patients before and after oral aspirin challenge. J Allergy Clin Immunol. 1992 Oct; 90(4 Pt 1):636-45. PMID: 1328344.
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    122. Mathews KP, Mentyka RA, Chambers SL, Hugli TE, Herschbach JH, Zuraw B. Cold-dependent activation of complement: recognition, assessment, and mechanism. J Clin Immunol. 1992 Sep; 12(5):362-70. PMID: 1430107.
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    123. Christiansen SC, Proud D, Sarnoff RB, Juergens U, Cochrane CG, Zuraw B. Elevation of tissue kallikrein and kinin in the airways of asthmatic subjects after endobronchial allergen challenge. Am Rev Respir Dis. 1992 Apr; 145(4 Pt 1):900-5. PMID: 1554219.
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    124. Zuraw B, Altman LC. Acute consumption of C1 inhibitor in a patient with acquired C1-inhibitor deficiency syndrome. J Allergy Clin Immunol. 1991 Dec; 88(6):908-18. PMID: 1744362.
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    125. Zuraw B, Lotz M. Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating factors interleukin 6 and interferon gamma. J Biol Chem. 1990 Jul 25; 265(21):12664-70. PMID: 1695634.
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    126. Guerne PA, Terkeltaub R, Zuraw B, Lotz M. Inflammatory microcrystals stimulate interleukin-6 production and secretion by human monocytes and synoviocytes. Arthritis Rheum. 1989 Nov; 32(11):1443-52. PMID: 2554932.
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    127. Christiansen SC, Zuraw B, Proud D, Cochrane CG. Inhibition of human bronchial kallikrein in asthma. Am Rev Respir Dis. 1989 May; 139(5):1125-31. PMID: 2785358.
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    128. Lang DM, Sugimoto SL, Curd JG, Christiansen SC, Zuraw B. High-molecular-weight kininogen is cleaved in active erythema multiforme. J Allergy Clin Immunol. 1989 Apr; 83(4):802-10. PMID: 2708741.
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    129. Guerne PA, Zuraw B, Vaughan JH, Carson DA, Lotz M. Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest. 1989 Feb; 83(2):585-92. PMID: 2464001; PMCID: PMC303718.
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    131. Lotz M, Zuraw B. Interferon-gamma is a major regulator of C1-inhibitor synthesis by human blood monocytes. J Immunol. 1987 Nov 15; 139(10):3382-7. PMID: 3119706.
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    132. Zuraw B, Sugimoto S, Curd JG. The value of rocket immunoelectrophoresis for C4 activation in the evaluation of patients with angioedema or C1-inhibitor deficiency. J Allergy Clin Immunol. 1986 Dec; 78(6):1115-20. PMID: 3782676.
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    133. Zuraw B, Curd JG. Demonstration of modified inactive first component of complement (C1) inhibitor in the plasmas of C1 inhibitor-deficient patients. J Clin Invest. 1986 Aug; 78(2):567-75. PMID: 3734104; PMCID: PMC423595.