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    Hans Spiegelberg

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0831
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      ROLE OF CYTOKINES IN ALLERGIC DISORDERS
      NIH/NIAID U01AI031595Sep 1, 1991 - Aug 31, 1995
      Role: Principal Investigator
      IGE AND IGG SUBCLASS FORMATION
      NIH/NIAID R01AI010734Jan 1, 1977 - Dec 31, 1993
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hayashi T, Gong X, Rossetto C, Shen C, Takabayashi K, Redecke V, Spiegelberg H, Broide D, Raz E. Induction and inhibition of the Th2 phenotype spread: implications for childhood asthma. J Immunol. 2005 May 1; 174(9):5864-73. PMID: 15843591.
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      2. Spiegelberg H, Horner AA, Takabayashi K, Raz E. Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy. Curr Opin Allergy Clin Immunol. 2002 Dec; 2(6):547-51. PMID: 14752340.
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      3. Horner AA, Takabayashi K, Beck L, Sharma B, Zubeldia J, Baird S, Tuck S, Libet L, Spiegelberg H, Liu FT, Raz E. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity. J Allergy Clin Immunol. 2002 Sep; 110(3):413-20. PMID: 12209088.
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      4. Spiegelberg H, Takabayashi K, Beck L, Raz E. DNA-based vaccines for allergic disease. Expert Rev Vaccines. 2002 Aug; 1(2):169-77. PMID: 12901556.
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      5. Spiegelberg H, Raz E. DNA-based approaches to the treatment of allergies. Curr Opin Mol Ther. 2002 Feb; 4(1):64-71. PMID: 11883696.
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      6. Horner AA, Widhopf GF, Burger JA, Takabayashi K, Cinman N, Ronaghy A, Spiegelberg H, Raz E. Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells. J Allergy Clin Immunol. 2001 Sep; 108(3):417-23. PMID: 11544462.
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      7. Tighe H, Takabayashi K, Schwartz D, Van Nest G, Tuck S, Eiden JJ, Kagey-Sobotka A, Creticos PS, Lichtenstein LM, Spiegelberg H, Raz E. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol. 2000 Jul; 106(1 Pt 1):124-34. PMID: 10887315.
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      8. Tighe H, Takabayashi K, Schwartz D, Marsden R, Beck L, Corbeil J, Richman DD, Eiden JJ, Spiegelberg H, Raz E. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity. Eur J Immunol. 2000 Jul; 30(7):1939-47. PMID: 10940883.
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      9. Roman M, Tighe H, Spiegelberg H, Broide D, Raz E. Genetic immunization for allergy immunotherapy. Methods Mol Med. 2000; 29:451-72. PMID: 21374341.
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      10. Spiegelberg H, Broide D, Tighe H, Roman M, Raz E. Inhibition of allergic inflammation in the lung by plasmid DNA allergen immunization. Pediatr Pulmonol Suppl. 1999; 18:118-21. PMID: 10093118.
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      11. Spiegelberg H, Raz E. DNA vaccines. Allergy. 1999; 54 Suppl 56:47-8. PMID: 10532307.
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      12. Raz E, Spiegelberg H. Deviation of the allergic IgE to an IgG response by gene immunotherapy. Int Rev Immunol. 1999; 18(3):271-89. PMID: 10614729.
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      13. Spiegelberg H, Raz E. DNA based immunotherapeutics for allergy. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 1999; (93):283-90; discussion 291-2. PMID: 11487889.
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      14. Spiegelberg H, Tighe H, Roman M, Broide D, Raz E. Inhibition of IgE formation and allergic inflammation by allergen gene immunization and by CpG motif immunostimulatory oligodeoxynucleotides. Allergy. 1998; 53(45 Suppl):93-7. PMID: 9788716.
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      15. Griswold WR, Krous HF, Reznik V, Lemire J, Wilson NW, Bastian J, Spiegelberg H. The syndrome of autoimmune interstitial nephritis and membranous nephropathy. Pediatr Nephrol. 1997 Dec; 11(6):699-702. PMID: 9438646.
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      16. Spiegelberg H, Orozco EM, Roman M, Raz E. DNA immunization: a novel approach to allergen-specific immunotherapy. Allergy. 1997 Oct; 52(10):964-70. PMID: 9360746.
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      17. Lee DJ, Tighe H, Corr M, Roman M, Carson DA, Spiegelberg H, Raz E. Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells. Int Arch Allergy Immunol. 1997 May-Jul; 113(1-3):227-30. PMID: 9130530.
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      18. Roman M, Spiegelberg H, Broide D, Raz E. Gene immunization for allergic disorders. Springer Semin Immunopathol. 1997; 19(2):223-32. PMID: 9406348.
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      19. Roth R, Spiegelberg H. Activation of cloned human CD4+ Th1 and Th2 cells by blood dendritic cells. Scand J Immunol. 1996 Jun; 43(6):646-51. PMID: 8658054.
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      20. Raz E, Tighe H, Sato Y, Corr M, Dudler JA, Roman M, Swain SL, Spiegelberg H, Carson DA. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):5141-5. PMID: 8643542.
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      21. Beck L, Roth R, Spiegelberg H. Comparison of monocytes and B cells for activation of human T helper cell subsets. Clin Immunol Immunopathol. 1996 Jan; 78(1):56-60. PMID: 8599884.
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      22. Nguyen DD, Beck L, Spiegelberg H. Anti-CD3-induced anergy in cloned human Th0, Th1, and Th2 cells. Cell Immunol. 1995 Oct 1; 165(1):153-7. PMID: 7671320.
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      23. Lemire JM, Archer DC, Beck L, Spiegelberg H. Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J Nutr. 1995 Jun; 125(6 Suppl):1704S-1708S. PMID: 7782931.
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      24. Azmi FH, Lucas AH, Spiegelberg H, Granoff DM. Human immunoglobulin M paraproteins cross-reactive with Neisseria meningitidis group B polysaccharide and fetal brain. Infect Immun. 1995 May; 63(5):1906-13. PMID: 7729901.
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      25. Spiegelberg H, Beck L, Stevenson DD, Ishioka GY. Recognition of T cell epitopes and lymphokine secretion by rye grass allergen Lolium perenne I-specific human T cell clones. J Immunol. 1994 May 1; 152(9):4706-11. PMID: 7512603.
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      26. Spiegelberg H, Beck L, Kocher HP, Fanslow WC, Lucas AH. Role of interleukin-4 in human immunoglobulin E formation in hu-PBL-SCID mice. J Clin Invest. 1994 Feb; 93(2):711-7. PMID: 8113405.
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      27. Gonzalez S, Beck L, Wilson N, Spiegelberg H. Comparison of interferon-gamma and interleukin-4 production by peripheral blood mononuclear cells and isolated T cells after activation with polyclonal T cell activators. J Clin Lab Anal. 1994; 8(5):277-83. PMID: 7807282.
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      28. Ninomiya C, Spiegelberg H. IL-4 and transforming growth factor-beta suppress human immunoglobulin secretion in vitro by surface IgD- B cells. Clin Exp Immunol. 1992 Aug; 89(2):261-8. PMID: 1638770.
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      29. Spiegelberg H, Falkoff RJ, O'Connor RD, Beck L. Interleukin-2 inhibits the interleukin-4-induced human IgE and IgG4 secretion in vivo. Clin Exp Immunol. 1991 Jun; 84(3):400-5. PMID: 1904325.
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      30. Spiegelberg H. Fc epsilon R2/CD23: its discovery and possible functions. Monogr Allergy. 1991; 29:1-8. PMID: 1836531.
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      31. Spiegelberg H, O'Connor RD, Falkoff RJ, Beck L. Interleukin-4 induced IgE and IgG4 secretion by B cells from atopic dermatitis patients. Int Arch Allergy Appl Immunol. 1991; 94(1-4):181-3. PMID: 1937871.
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      32. Claman HN, Spiegelberg H. Immunoglobulin dysregulation in murine graft-vs-host disease: a hyper-IgE syndrome. Clin Immunol Immunopathol. 1990 Jul; 56(1):46-53. PMID: 2357859.
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      33. Lenert P, Kroon D, Spiegelberg H, Golub ES, Zanetti M. Human CD4 binds immunoglobulins. Science. 1990 Jun 29; 248(4963):1639-43. PMID: 2363051.
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      34. Spiegelberg H. Fc receptors for IgE and interleukin-4 induced IgE and IgG4 secretion. J Invest Dermatol. 1990 Jun; 94(6 Suppl):49S-52S. PMID: 2191055.
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      35. Spiegelberg H. The role of interleukin-4 in IgE and IgG subclass formation. Springer Semin Immunopathol. 1990; 12(4):365-83. PMID: 2096469.
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      36. Nüsslein HG, Spiegelberg H. Interleukin-4 induces both IgG4 and IgE secretion by peripheral blood B cells. J Clin Lab Anal. 1990; 4(6):414-9. PMID: 2126556.
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      37. Beck L, Spiegelberg H. The polyclonal and antigen-specific IgE and IgG subclass response of mice injected with ovalbumin in alum or complete Freund's adjuvant. Cell Immunol. 1989 Oct 1; 123(1):1-8. PMID: 2776217.
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      38. Zakroff SG, Beck L, Platzer EG, Spiegelberg H. The IgE and IgG subclass responses of mice to four helminth parasites. Cell Immunol. 1989 Mar; 119(1):193-201. PMID: 2522026.
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      39. Lebrun P, Lucas AH, McKenzie DT, Spiegelberg H. Interleukin 4 acts on both high- and low-density murine B cell subpopulations to induce IgE and IgG1 synthesis in vitro. Int Arch Allergy Appl Immunol. 1989; 88(1-2):108-10. PMID: 2785084.
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      40. Spiegelberg H. Biological role of different antibody classes. Int Arch Allergy Appl Immunol. 1989; 90 Suppl 1:22-7. PMID: 2693365.
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      41. Ferreri NR, Zeiger RS, Spiegelberg H. IgG-, IgA-, and IgE-induced release of leukotriene C4 by monocytes isolated from patients with atopic dermatitis. J Allergy Clin Immunol. 1988 Oct; 82(4):556-67. PMID: 2844875.
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      42. Lebrun P, Sidman CL, Spiegelberg H. IgE formation and Fc receptor-positive lymphocytes in normal, immuno-deficient, and auto-immune mice infected with Nippostrongylus brasiliensis. J Immunol. 1988 Jul 1; 141(1):249-57. PMID: 2967867.
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      43. Crowley JJ, Goldfien RD, Schrohenloher RE, Spiegelberg H, Silverman GJ, Mageed RA, Jefferis R, Koopman WJ, Carson DA, Fong S. Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins. J Immunol. 1988 May 15; 140(10):3411-8. PMID: 3129494.
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      44. Ferreri NR, Howland WC, Stevenson DD, Spiegelberg H. Release of leukotrienes, prostaglandins, and histamine into nasal secretions of aspirin-sensitive asthmatics during reaction to aspirin. Am Rev Respir Dis. 1988 Apr; 137(4):847-54. PMID: 2451458.
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      45. Lebrun P, Spiegelberg H. Concomitant immunoglobulin E and immunoglobulin G1 formation in Nippostrongylus brasiliensis-infected mice. J Immunol. 1987 Sep 1; 139(5):1459-65. PMID: 3624863.
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      46. Spiegelberg H. The expression of IgE Fc receptors on lymphocytes of allergic patients. Int Rev Immunol. 1987 Jan; 2(1):63-74. PMID: 2976800.
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      47. Rubin RL, Tang FL, Lucas AH, Spiegelberg H, Tan EM. IgG subclasses of anti-tetanus toxoid antibodies in adult and newborn normal subjects and in patients with systemic lupus erythematosus, Sjogren's syndrome, and drug-induced autoimmunity. J Immunol. 1986 Oct 15; 137(8):2522-7. PMID: 3760565.
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      48. Ferreri NR, Howland WC, Spiegelberg H. Release of leukotrienes C4 and B4 and prostaglandin E2 from human monocytes stimulated with aggregated IgG, IgA, and IgE. J Immunol. 1986 Jun 1; 136(11):4188-93. PMID: 3009617.
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      49. Spiegelberg H, Melewicz FM, Ferreri NR. IgE Fc receptors on monocytes and allergy. Ann Inst Pasteur Immunol. 1986 May-Jun; 137C(3):358-63. PMID: 2943212.
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      50. Ferreri NR, Beck L, Spiegelberg H. beta-Glucuronidase release from human monocytes induced with aggregated immunoglobulins of different classes. Cell Immunol. 1986 Mar; 98(1):57-67. PMID: 2427225.
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      51. Spiegelberg H, Canning KM, Scheetz M, Koppel G, Chiller JM. Effect of myeloma IgE injections on passive and active cutaneous anaphylaxis in rats. J Immunol. 1986 Jan; 136(1):131-5. PMID: 3484388.
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      52. Capron M, Kusnierz JP, Prin L, Spiegelberg H, Ovlaque G, Gosset P, Tonnel AB, Capron A. Cytophilic IgE on human blood and tissue eosinophils: detection by flow microfluorometry. J Immunol. 1985 May; 134(5):3013-8. PMID: 3156925.
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      53. Thompson LF, Spiegelberg H, Buckley RH. IgE Fc receptor positive T and B lymphocytes in patients with the hyper IgE syndrome. Clin Exp Immunol. 1985 Jan; 59(1):77-84. PMID: 3882288.
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      54. Spiegelberg H. Immunoglobulin D (IgD). Methods Enzymol. 1985; 116:95-101. PMID: 3937029.
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      55. Capron M, Kusnierz JP, Prin L, Spiegelberg H, Khalife J, Tonnel AB, Capron A. Cytophilic IgE on human blood and tissue eosinophils. Int Arch Allergy Appl Immunol. 1985; 77(1-2):246-8. PMID: 3159685.
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      56. Spiegelberg H, Thompson LF, McNeil D, Buckley RH. IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome. Int Arch Allergy Appl Immunol. 1985; 77(1-2):277-9. PMID: 3159686.
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      57. Jensen JR, Sand TT, Spiegelberg H. Generation of IgE-binding and IgG-binding factors from human lymphoblastoid cell lines. Immunology. 1984 Sep; 53(1):1-8. PMID: 6469280.
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      58. Boltz-Nitulescu G, Plummer JM, Spiegelberg H. Increased expression of the IgE Fc receptors on rat macrophages induced by elevated serum IgE levels. Immunology. 1984 Sep; 53(1):9-16. PMID: 6236146.
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      59. Capron M, Spiegelberg H, Prin L, Bennich H, Butterworth AE, Pierce RJ, Ouaissi MA, Capron A. Role of IgE receptors in effector function of human eosinophils. J Immunol. 1984 Jan; 132(1):462-8. PMID: 6228581.
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      60. Spiegelberg H. Structure and function of Fc receptors for IgE on lymphocytes, monocytes, and macrophages. Adv Immunol. 1984; 35:61-88. PMID: 6431765.
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      61. Thompson LF, Mellon MH, Zeiger RS, Spiegelberg H. Characterization with monoclonal antibodies of T lymphocytes bearing Fc receptors for IgE (T epsilon cells) and IgG (T gamma cells) in atopic patients. J Immunol. 1983 Dec; 131(6):2772-6. PMID: 6227666.
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      62. Spiegelberg H, Plummer JM, Ruedi J, Thompson LF, Mellon MH, Zeiger RS. Lack of pokeweed mitogen-induced IgE formation in vitro by human peripheral blood mononuclear cells: detection of cross-reacting idiotypic determinants on polyclonal Ig by antibodies to a single IgE myeloma protein. J Immunol. 1983 Dec; 131(6):3001-5. PMID: 6417237.
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      63. Boltz-Nitulescu G, Melewicz FM, Plummer JM, Spiegelberg H. Fc receptor for IgE on rat, mouse and human macrophages and macrophage-like cell lines: their relationship to serum IgE level. Monogr Allergy. 1983; 18:160-2. PMID: 6227814.
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      64. Spiegelberg H, Thompson LF, Mellon MH, Zeiger RS. FC epsilon receptor-positive B and T lymphocytes in atopic disease. Monogr Allergy. 1983; 18:25-32. PMID: 6227817.
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      65. Spiegelberg H. Fc receptors for IgE on macrophages and lymphocytes: IgE synthesis. Introduction. Fed Proc. 1983 Jan; 42(1):122-3. PMID: 6401248.
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      66. Spiegelberg H, Boltz-Nitulescu G, Plummer JM, Melewicz FM. Characterization of the IgE Fc receptors on monocytes and macrophages. Fed Proc. 1983 Jan; 42(1):124-8. PMID: 6401249.
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      67. Melewicz FM, Kline LE, Cohen AB, Spiegelberg H. Characterization of Fc receptors for IgE on human alveolar macrophages. Clin Exp Immunol. 1982 Aug; 49(2):364-70. PMID: 7127909.
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      68. Melewicz FM, Plummer JM, Spiegelberg H. Comparison of the Fc receptors for IgE on human lymphocytes and monocytes. J Immunol. 1982 Aug; 129(2):563-9. PMID: 6211489.
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      69. Boltz-Nitulescu G, Plummer JM, Spiegelberg H. Fc receptors for IgE on mouse macrophages and macrophage-like cell lines. J Immunol. 1982 May; 128(5):2265-8. PMID: 7061861.
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      70. Kocher HP, Spiegelberg H. Studies of human myeloma and cell bound IgD. Ann N Y Acad Sci. 1982; 399:69-81. PMID: 6819803.
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      71. Spiegelberg H, Simon RA. Increase of lymphocytes with Fc receptors for IgE in patients with allergic rhinitis during the grass pollen season. J Clin Invest. 1981 Oct; 68(4):845-52. PMID: 7287905.
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      72. Boltz-Nitulescu G, Bazin H, Spiegelberg H. Specificity of fc receptors for IgG2a, IgG1/IgG2b, and IgE on rat macrophages. J Exp Med. 1981 Aug 1; 154(2):374-84. PMID: 6167653.
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      73. Marsh WL, Worthman JW, Spiegelberg H. The pathology of gamma heavy chain disease: report of a case with morphologic progression from lymphocytic to plasmacytic proliferation. Cancer. 1981 Jun 15; 47(12):2878-82. PMID: 6790158.
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      74. Anderson CL, Spiegelberg H. Macrophage receptors for IgE: binding of IgE to specific IgE Fc receptors on a human macrophage cell line, U937. J Immunol. 1981 Jun; 126(6):2470-3. PMID: 7014719.
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      75. Melewicz FM, Zeiger RS, Mellon MH, O'Connor RD, Spiegelberg H. Increased peripheral blood monocytes with Fc receptors for IgE in patients with severe allergic disorders. J Immunol. 1981 Apr; 126(4):1592-5. PMID: 7204979.
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      76. Boltz-Nitulescu G, Spiegelberg H. Receptors specific for IgE on rat alveolar and peritoneal macrophages. Cell Immunol. 1981 Mar 15; 59(1):106-14. PMID: 6971176.
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      77. Melewicz FM, Zeiger RS, Mellon MH, O'Connor RD, Spiegelberg H. Increased IgE-dependent cytotoxicity by blood mononuclear cells of allergic patients. Clin Exp Immunol. 1981 Mar; 43(3):526-33. PMID: 7285390.
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      78. Spiegelberg H. Lymphocytes bearing Fc receptors for IgE. Immunol Rev. 1981; 56:199-218. PMID: 7016734.
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      79. Fritsche R, Meinke GC, Spiegelberg H. Immunoprecipitation of the solubilized membrane receptor for IgE of human cultured lymphoblastoid cells. Scand J Immunol. 1981; 13(3):225-30. PMID: 7233092.
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      80. Dunne JV, Spiegelberg H, Vaughan JH. A comparison of EA-Rosette formation on lymphocytes using rabbit and human sensitizing antibodies. Scand J Immunol. 1981; 13(2):189-97. PMID: 7015486.
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      81. Melewicz FM, Spiegelberg H. Fc receptors for IgE on a subpopulation of human peripheral blood monocytes. J Immunol. 1980 Sep; 125(3):1026-31. PMID: 7190991.
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      82. Boss GR, Thompson LF, Spiegelberg H, Pichler WJ, Seegmiller JE. Age-dependency of lymphocyte ecto-5'-nucleotidase activity. J Immunol. 1980 Aug; 125(2):679-82. PMID: 6248594.
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      83. Thompson LF, Boss GR, Spiegelberg H, Bianchino A, Seegmiller JE. Ecto-5'-nucleotidase activity in lymphoblastoid cell lines derived from heterozygotes for congenital X-linked agammaglobulinemia. J Immunol. 1980 Jul; 125(1):190-3. PMID: 6247393.
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      84. Spiegelberg H, Melewicz FM. Fc receptors specific for IgE on subpopulations of human lymphocytes and monocytes. Clin Immunol Immunopathol. 1980 Mar; 15(3):424-33. PMID: 7371227.
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      85. Ring J, Allen DH, Mathison DA, Spiegelberg H. In vitro releasability of histamine and serotonin: studies of atopic patients. J Clin Lab Immunol. 1980 Mar; 3(2):85-91. PMID: 6162959.
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      86. Thompson LF, Boss GR, Spiegelberg H, Jansen IV, O'Connor RD, Waldmann TA, Hamburger RN, Seegmiller JE. Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia. J Immunol. 1979 Dec; 123(6):2475-8. PMID: 315423.
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      87. Spiegelberg H, O'Connor RD, Simon RA, Mathison DA. Lymphocytes with immunoglobulin E Fc receptors in patients with atopic disorders. J Clin Invest. 1979 Sep; 64(3):714-20. PMID: 112109.
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      88. Dunne JV, Carson DA, Spiegelberg H, Alspaugh MA, Vaughan JH. IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjögren's syndrome. Ann Rheum Dis. 1979 Apr; 38(2):161-5. PMID: 443882.
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      89. Kocher HP, Spiegelberg H. Tryptic degradation of the CH1 and VL regions of IgD and IgE. J Immunol. 1979 Apr; 122(4):1190-5. PMID: 448085.
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      90. Spiegelberg H, Dainer PM. Fc receptors for IgG, IgM and IgE on human leukaemic lymphocytes. Clin Exp Immunol. 1979 Feb; 35(2):286-95. PMID: 312174.
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      91. Hellström U, Spiegelberg H. Characterization of human lymphocytes bearing Fc receptors for IgE isolated from blood and lymphoid organs. Scand J Immunol. 1979; 9(1):75-86. PMID: 368962.
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      92. Doe WF, Spiegelberg H. Characterization of an antiserum specific for the Fabalpha fragment. Its use for detection of alpha-heavy chain disease protein by immunoselection. J Immunol. 1979 Jan; 122(1):19-23. PMID: 762416.
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      93. Berman MA, Spiegelberg H, Weigle WO. Lymphocyte stimulation with Fc fragments. I. Class, subclass, and domain of active fragments. J Immunol. 1979 Jan; 122(1):89-96. PMID: 762426.
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      94. Boss GR, Thompson LF, Spiegelberg H, Waldmann TA, O'Connor RD, Hamburger RN, Seegmiller JE. Lymphocyte ecto-5'-nucleotidase activity as a marker of B-cell maturation. Trans Assoc Am Physicians. 1979; 92:309-15. PMID: 232944.
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      95. Morgan EL, Spiegelberg H, Weigle WO. Comparison of the binding of radiolabelled human IgG and Fc fragments to murine spleen cells. Scand J Immunol. 1979; 10(5):395-402. PMID: 317535.
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      96. Meinke GC, Magro AM, Lawrence DA, Spiegelberg H. Characterization of an IgE receptor isolated from cultured B-type lymphoblastoid cells. J Immunol. 1978 Oct; 121(4):1321-8. PMID: 81229.
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      97. Fritsche R, Spiegelberg H. Fc receptors for IgE on normal rat lymphocytes. J Immunol. 1978 Aug; 121(2):471-8. PMID: 681743.
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      98. Kennel SJ, Levy RL, Spiegelberg H. Quantitation of antibodies to IgM, IgD and beta2-microglobulin in antisera to chronic lymphatic leukemia lymphocytes. Int Arch Allergy Appl Immunol. 1978; 57(6):498-506. PMID: 79557.
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      99. Troye M, Perlmann P, Pape GR, Spiegelberg H, Näslund I, Gidlöf A. The use of Fab fragments of anti-human immunoglobulin as analytic tools for establishing the involvement of immunoglobulin in the spontaneous cytotoxicity to cultured tumor cells by lymphocytes from patients with bladder carcinoma and from healthy donors. J Immunol. 1977 Sep; 119(3):1061-7. PMID: 302271.
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      100. Goyert SM, Hugli TE, Spiegelberg H. Sites of "spontaneous" degradation of IgD. J Immunol. 1977 Jun; 118(6):2138-44. PMID: 405424.
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      101. Gonzalez-Molina A, Spiegelberg H. A subpopulation of normal human peripheral B lymphcytes that bind IgE. J Clin Invest. 1977 Apr; 59(4):616-24. PMID: 321474.
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      102. Rothberger H, Zimmerman TS, Spiegelberg H, Vaughan JH. Leukocyte procoagulant activity: enhancement of production in vitro by IgG and antigen-antibody complexes. J Clin Invest. 1977 Mar; 59(3):549-57. PMID: 190271.
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      103. Spiegelberg H. The structure and biology of human IgD. Immunol Rev. 1977; 37:3-24. PMID: 338468.
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      104. Schumaker VN, Calcott MA, Spiegelberg H, Müller-Eberhard HJ. Ultracentifuge studies of the binding of IgG of different subclasses to the Clq subunit of the first component of complement. Biochemistry. 1976 Nov 16; 15(23):5175-81. PMID: 990273.
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      105. Spiegelberg H, Perlmann H, Perlmann P. Interaction of K lymphocytes with myeloma proteins of different IgG subclasses. J Immunol. 1976 Nov; 117(5 Pt 1):1464-71. PMID: 1002986.
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      106. Spiegelberg H, Fishkin BG. Human myeloma IgA half-molecules. J Clin Invest. 1976 Nov; 58(5):1259-65. PMID: 993344.
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      107. Meinke G, Spiegelberg H. Amino acid sequence of the first hypervariable region of 2 kappa and 2 lambda Bence Jones cryoglobulin. Immunochemistry. 1976 Nov; 13(11):915-9. PMID: 827495.
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      108. Gonzalez-Molina A, Spiegelberg H. Binding of IgE myeloma proteins to human cultured lymphoblastoid cells. J Immunol. 1976 Nov; 117(5 Pt.2):1838-45. PMID: 792332.
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      109. Fishkin BG, Spiegelberg H. Cervical lymph node metastasis as the first manifestation of localized extramedullary plasmacytoma. Cancer. 1976 Oct; 38(4):1641-4. PMID: 991083.
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      110. Zimmerman TS, Spiegelberg H. Pneumococcus-induced serotonin release from human platelets. Identification of the participating plasma/serum factor as immunoglobulin. J Clin Invest. 1975 Oct; 56(4):828-34. PMID: 239970.
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      111. Spiegelberg H. Human myeloma IgG half-molecules. Catabolism and biological properties. J Clin Invest. 1975 Sep; 56(3):588-94. PMID: 808559.
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      112. Edenhofer A, Spiegelberg H, Oberhänsli WE. [Studies on the Thorpe-Ziegler-reaction. A new synthesis of the pyridine part of thiamine]. Helv Chim Acta. 1975 Jun 4; 58(4):1230-40. PMID: 1158742.
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      113. Spiegelberg H, Heath VC, Lang JE. Human myeloma IgG half-molecules. Structural and antigenic analyses,. Biochemistry. 1975 May 20; 14(10):2157-63. PMID: 50083.
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      114. Spiegelberg H. NH2-terminal amino acid sequence of the Fc fragment of IgD resembles IgE and IgG sequences. Nature. 1975 Apr 24; 254(5502):723-5. PMID: 1124134.
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      115. Spiegelberg H, Heath VC, Lang JE. IgG half-molecules: clinical and immunologic features in a patient with plasma cell leukemia. Blood. 1975 Mar; 45(3):305-13. PMID: 803846.
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      116. Lawrence DA, Weigle WO, Spiegelberg H. Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils. J Clin Invest. 1975 Feb; 55(2):368-76. PMID: 1127105.
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      117. Meinke GC, Sigrist PH, Spiegelberg H. The NH2-terminal amino acid sequence of a kappa and a lambda Bence-Jones cryoglobulin. Immunochemistry. 1974 Aug; 11(8):457-60. PMID: 4218590.
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      118. Vallota EH, Götze O, Spiegelberg H, Forristal J, West CD, Müller-Eberhard HJ. A serum factor in chronic hypocomplementemic hephritis distinct from immunoglobulins and activating the alternate pathway of complement. J Exp Med. 1974 May 1; 139(5):1249-61. PMID: 4207623.
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      119. Meinke GC, Spiegelberg H. Antigenic studies of J chain. J Immunol. 1974 Apr; 112(4):1401-6. PMID: 4205528.
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      120. Spiegelberg H. Biological activities of immunoglobulins of different classes and subclasses. Adv Immunol. 1974; 19(0):259-94. PMID: 4611173.
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      121. Spiegelberg H, Lawrence DA, Henson P. Cytophilic properties of IgA to human neutrophils. Adv Exp Med Biol. 1974; 45(0):67-74. PMID: 4213018.
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      122. Henson PM, Spiegelberg H. Release of serotonin from human platelets induced by aggregated immunoglobulins of different classes and subclasses. J Clin Invest. 1973 May; 52(5):1282-8. PMID: 4700496.
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      123. Lawrence DA, Spiegelberg H, Weigle WO. 2,4-Dinitrophenyl receptors on mouse thymus and spleen cells. J Exp Med. 1973 Feb 1; 137(2):470-82. PMID: 4119592.
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      124. Henson PM, Johnson HB, Spiegelberg H. The release of granule enzymes from human neutrophils stimulated by aggregated immunoglobulins of different classes and subclasses. J Immunol. 1972 Dec; 109(6):1182-92. PMID: 4628704.
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      125. Cochrane CG, Wuepper KD, Aiken BS, Revak SD, Spiegelberg H. The interaction of Hageman factor and immune complexes. J Clin Invest. 1972 Oct; 51(10):2736-45. PMID: 5056666.
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      126. Meinke GC, Spiegelberg H. Structural studies of human J chain. J Immunol. 1972 Oct; 109(4):903-6. PMID: 4627515.
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      127. Spiegelberg H, Fishkin BG. The catabolism of human G immunoglobulins of different heavy chain subclasses. 3. The catabolism of heavy chain disease proteins and of Fc fragments of myeloma proteins. Clin Exp Immunol. 1972 Apr; 10(4):599-607. PMID: 4624553.
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      128. Fishkin BG, Orloff N, Scaduto LE, Borucki DT, Spiegelberg H. IgE multiple myeloma: a report of the third case. Blood. 1972 Mar; 39(3):361-7. PMID: 4621803.
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      129. Spiegelberg H, Abel CA, Fishkin BG, Grey HM. Localization of the carbohydrate within the variable region of light and heavy chains of human gamma g myeloma proteins. Biochemistry. 1970 Oct 13; 9(21):4217-23. PMID: 5458650.
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      130. Spiegelberg H, Prahl JW, Grey HM. Structural studies of human gamma D myeloma protein. Biochemistry. 1970 May 12; 9(10):2115-22. PMID: 4245598.
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      131. Fishkin BG, Glassy FJ, Hattersley PG, Hirose FM, Spiegelberg H. IgD multiple myeloma: a report of five cases. Am J Clin Pathol. 1970 Feb; 53(2):209-14. PMID: 5415911.
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      132. Tojo T, Friou GJ, Spiegelberg H. Immunoglobulin G subclass of human antinuclear antibodies. Clin Exp Immunol. 1970 Jan; 6(1):145-51. PMID: 4984586.
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      133. Spiegelberg H, Fishkin BG, Grey HM. Catabolism of human gammaG-immunoglobulins of different heavy chain subclasses. I. Catabolism of gammaG-myeloma proteins in man. J Clin Invest. 1968 Oct; 47(10):2323-30. PMID: 4175542.
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      134. Spiegelberg H, Grey HM. Catabolism of human gamma-G immunoglobulins of different heavy chain subclasses. II. Catabolism of gamma-G myeloma proteins in heterologous species. J Immunol. 1968 Oct; 101(4):711-6. PMID: 4176112.
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      135. Spiegelberg H, Weigle WO. The production of antisera to human gammaGlobulin subclasses in rabbits using immunological unresponsiveness. J Immunol. 1968 Aug; 101(2):377-80. PMID: 4174500.
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      136. Abel CA, Spiegelberg H, Grey HM. The carbohydrate contents of fragments and polypeptide chains of human gamma-G-myeloma proteins of different heavy-chain subclasses. Biochemistry. 1968 Apr; 7(4):1271-8. PMID: 4173998.
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      137. Nakamura RM, Spiegelberg H, Lee S, Weigle WO. Relationship between molecular size and intra- and extravascular diribution of protein antigens. J Immunol. 1968 Feb; 100(2):376-83. PMID: 5639703.
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      138. Weigle WO, Nakamura RM, Spiegelberg H, Golub ES, High GJ. Autoimmunity and termination of immunological unresponsiveness. Arch Pathol. 1967 Dec; 84(6):647-58. PMID: 4167987.
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      139. Spiegelberg H, Weigle WO. The immune response to human gamma-G-immunoglobulin in rabbits unresponsive to Fc fragment and H chain protein. J Immunol. 1967 May; 98(5):1020-7. PMID: 4164843.
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      140. Spiegelberg H, Weigle WO. The immune response in guinea pigs injected with heterologous and altered homologous thyroglobulin. Int Arch Allergy Appl Immunol. 1967; 31(6):559-67. PMID: 5298957.
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      141. Spiegelberg H, Weigle WO. An in vivo assay to determine the ability of antibody subunits to bind to antigen. Immunochemistry. 1966 Jul; 3(4):341-2. PMID: 4164841.
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      142. Spiegelberg H, Weigle WO. The in vivo formation and fate of antigen-antibody complexes formed by fragments and polypeptide chains of rabbit gamma-G-antibodies. J Exp Med. 1966 Jun 1; 123(6):999-1012. PMID: 4161311.
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      143. Spiegelberg H, Weigle WO. Studies on the catabolism of gamma- G subunits and chains. J Immunol. 1965 Dec; 95(6):1034-40. PMID: 4158797.
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      144. SPIEGELBERG HL, WEIGLE WO. THE CATABOLISM OF HOMOLOGOUS AND HETEROLOGOUS 7S GAMMA GLOBULIN FRAGMENTS. J Exp Med. 1965 Mar 1; 121:323-38. PMID: 14271318.
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      145. SPIEGELBERG HL, WEIGLE WO. EFFECT OF AN ALPHA-2 GLOBULIN FRACTION ON ANTIBODY FORMATION IN RABBITS AND MICE. Proc Soc Exp Biol Med. 1964 Nov; 117:413-6. PMID: 14233457.
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      146. SPIEGELBERG HL, MIESCHER PA. THE EFFECT OF 6-MERCAPTOPURINE AND AMINOPTERIN ON EXPERIMENTAL IMMUNE THYROIDITIS IN GUINEA PIGS. J Exp Med. 1963 Nov 1; 118:869-90. PMID: 14087626.
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      147. VATERLAUS BP, DOEBEL K, KISS J, RACHLIN AI, SPIEGELBERG H. [THE SYNTHESIS OF NOVOBIOCIN]. Experientia. 1963 Aug 15; 19:383-91. PMID: 14084044.
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      148. SPIEGELBERG HL, MIESCHER PA, BENACERRAF B. STUDIES ON THE ROLE OF COMPLEMENT IN THE IMMUNE CLEARANCE OF ESCHERICHIA COLI AND RAT ERYTHROCYTES BY THE RETICULOENDOTHELIAL SYSTEM IN MICE. J Immunol. 1963 May; 90:751-9. PMID: 14053293.
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      149. DOERNER M, ENDERLIN M, SPIEGELBERG H, MIESCHER P. [Clinical aspects and serology of visceral lupus erythematosus]. Dtsch Med Wochenschr. 1961 Mar 10; 86:431-9. PMID: 13723427.
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      150. DOERNER M, ENDERLIN M, SPIEGELBERG H, MIESCHER P. [Clinical aspects and serology of visceral lupus erythematosus]. Dtsch Med Wochenschr. 1961 Mar 3; 86:378-82 contd. PMID: 13723426.
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      151. RIEDER HP, RITZEL G, SPIEGELBERG H, GNIRSS F. [Serological tests for the detection of "taraxein"]. Experientia. 1960 Dec 15; 16:561-2. PMID: 13741515.
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      152. von RECHENBERG H, SPIEGELBERG HL. [The therapy of degenerative rheumatism with "librium" (Roche)]. Schweiz Med Wochenschr. 1960 Oct 1; 90:1121-4. PMID: 13740156.
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      153. SPIEGELBERG H, SPIEGELBERG U. [Late central nervous system disorders after severe acute tetra-ethyl lead poisoning]. Fortschr Neurol Psychiatr. 1958 May; 26(5):248-59. PMID: 13548270.
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      154. SPIEGELBERG H, SCHLAPFER R, ZBINDEN G, STUDER A. [A new injectable solvent (glycofurol)]. Arzneimittelforschung. 1956 Feb; 6(2):75-7. PMID: 13315069.
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      155. FROMHERZ K, SPIEGELBERG H. [Not Available]. Helv Physiol Pharmacol Acta. 1948; 6(1):42-54. PMID: 18915262.
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