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    David Broide

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0635
    CA La Jolla 92093
    Phone858-534-2374
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      Collapse Overview 
      Collapse Overview
      Research Interests
      Mechanisms of allergic inflammation and asthma
      Airway hyperreactivity, airway inflammation, mucus expression, and airway remodeling
      Immunohistology and image analysis quantitation of eosinophils, mast cells, T cells, and macrophages in the lung
      Eosinophils and mast cells in vitro and in vivo


      Collapse Research 
      Collapse Research Activities and Funding
      GSDMB and mucosal allergic response
      NIH/NIAID R01AI124236Sep 1, 2016 - Aug 31, 2021
      Role: Principal Investigator
      Chromosome 17q, allergic inflammation, and remodeling
      NIH/NIAID R01AI107779May 15, 2013 - Apr 30, 2018
      Role: Principal Investigator
      LIAI Epitope Validation Center: Characterization of Allergen specific T Cells
      NIH U19AI100275Apr 1, 2012 - Mar 31, 2017
      Role: Co-Investigator
      Siglec-F and Resolution of Allergic Inflammation
      NIH/NIAID R01AI072115Dec 15, 2007 - Nov 30, 2013
      Role: Principal Investigator
      Airway inflammation and airway remodeling
      NIH/NIAID U19AI070535Jul 1, 2006 - Aug 31, 2021
      Role: Principal Investigator
      Biomarkers in sputum in COPD
      NIH/NHLBI R01HL072342Sep 23, 2002 - Jul 31, 2008
      Role: Principal Investigator
      RSV AND ASTHMA
      NIH/NIAID R01AI045513Mar 1, 1999 - Feb 28, 2005
      Role: Principal Investigator
      Eosinophil trafficking and chronic tissue damage induced by allergic inflammation
      NIH/NIAID R37AI038425Apr 1, 1996 - Nov 30, 2016
      Role: Principal Investigator
      Eosinophil Trafficking
      NIH/NIAID R01AI038425Apr 1, 1996 - Dec 14, 2006
      Role: Principal Investigator
      Training in Molecular and Cell Biology of Allergy
      NIH/NIAID T32AI007469Sep 30, 1994 - Jun 30, 2019
      Role: Principal Investigator
      ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
      NIH/NIAID R01AI033977May 1, 1994 - Dec 31, 2002
      Role: Principal Investigator
      ASTHMA--CYTOKINES AND AIRWAY INFLAMMATION
      NIH/NIAID R29AI029974Mar 1, 1991 - Feb 29, 1996
      Role: Principal Investigator
      GROWTH FACTOR REGULATION OF MUCOSAL MAST CELLS
      NIH/NIAID K08AI000845Sep 30, 1987 - Aug 31, 1990
      Role: Principal Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Unno H, Miller M, Rosenthal P, Beppu A, Das S, Broide D. ATF6a regulates airway hyperreactivity, smooth muscle proliferation, and contractility. J Allergy Clin Immunol. 2017 Sep 26. PMID: 28958904.
        View in: PubMed
      2. Chen J, Miller M, Unno H, Rosenthal P, Sanderson M, Broide D. Ormdl3 Upregulates Airway Smooth Muscle Proliferation, Contraction, and Ca2+ Oscillations in Asthma. J Allergy Clin Immunol. 2017 Sep 07. PMID: 28889952.
        View in: PubMed
      3. Song DJ, Miller M, Beppu A, Rosenthal P, Das S, Karta M, Vuong C, Mehta AK, Croft M, Broide D. Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation. J Immunol. 2017 Oct 01; 199(7):2215-2224. PMID: 28827284.
        View in: PubMed
      4. Das S, Miller M, Broide D. Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases. Adv Immunol. 2017; 135:1-52. PMID: 28826527.
        View in: PubMed
      5. Lund SJ, Portillo A, Cavagnero K, Baum RE, Naji LH, Badrani JH, Mehta A, Croft M, Broide D, Doherty TA. Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. J Immunol. 2017 Aug 01; 199(3):1096-1104. PMID: 28667163.
        View in: PubMed
      6. Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J, Broide D, Dong L. Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma. Am J Physiol Lung Cell Mol Physiol. 2017 Jul 01; 313(1):L27-L40. PMID: 28473327.
        View in: PubMed
      7. Karta MR, Rosenthal PS, Beppu A, Vuong CY, Miller M, Das S, Kurten RC, Doherty TA, Broide D. ß2 integrins rather than ß1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung. J Allergy Clin Immunol. 2017 Mar 30. PMID: 28366795.
        View in: PubMed
      8. Eastman JJ, Cavagnero KJ, Deconde AS, Kim AS, Karta MR, Broide D, Zuraw BL, White AA, Christiansen SC, Doherty TA. Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2017 Jul; 140(1):101-108.e3. PMID: 28279492.
        View in: PubMed
      9. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide D, Akuthota P, Crotty Alexander LE. Hypoxia-inducible factor-1a inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma. Clin Immunol. 2017 Mar; 176:94-99. PMID: 28093362.
        View in: PubMed
      10. Doherty TA, Broide D. Pathways to limit group 2 innate lymphoid cell activation. J Allergy Clin Immunol. 2017 Jan 10. PMID: 28087226.
        View in: PubMed
      11. Kim AS, Broide D. Acute renal dysfunction caused by nonsucrose intravenous immunoglobulin in common variable immunodeficiency. Ann Allergy Asthma Immunol. 2017 Feb; 118(2):231-233. PMID: 28024991.
        View in: PubMed
      12. Miller M, Rosenthal P, Beppu A, Gordillo R, Broide D. Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide. J Allergy Clin Immunol. 2017 Apr; 139(4):1373-1376.e4. PMID: 27826095.
        View in: PubMed
      13. Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide D. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46):13132-13137. PMID: 27799535.
        View in: PubMed
      14. Miller M, Esnault S, Kurten RC, Kelly EA, Beppu A, Das S, Rosenthal P, Ramsdell J, Croft M, Zuraw B, Jarjour N, Hamid Q, Broide D. Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma. J Allergy Clin Immunol. 2016 Aug; 138(2):596-599.e4. PMID: 27001159; PMCID: PMC4975994 [Available on 08/01/17].
        View in: PubMed, PubMed Central
      15. Rawson R, Yang T, Newbury RO, Aquino M, Doshi A, Bell B, Broide D, Dohil R, Kurten R, Aceves SS. TGF-ß1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2016 Sep; 138(3):791-800.e4. PMID: 27212082; PMCID: PMC5014565 [Available on 09/01/17].
        View in: PubMed, PubMed Central
      16. Kim AS, Doherty TA, Karta MR, Das S, Baum R, Rosenthal P, Beppu A, Miller M, Kurten R, Broide D. Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis. J Allergy Clin Immunol. 2016 Oct; 138(4):1192-1195.e5. PMID: 27142393.
        View in: PubMed
      17. Cho S, Wu CJ, Yasuda T, Cruz LO, Khan AA, Lin LL, Nguyen DT, Miller M, Lee HM, Kuo ML, Broide D, Rajewsky K, Rudensky AY, Lu LF. miR-23~27~24 clusters control effector T cell differentiation and function. J Exp Med. 2016 Feb 08; 213(2):235-49. PMID: 26834155; PMCID: PMC4749926.
        View in: PubMed, PubMed Central
      18. Karta MR, Broide D, Doherty TA. Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease. Curr Allergy Asthma Rep. 2016 Jan; 16(1):8. PMID: 26746844; PMCID: PMC5026503.
        View in: PubMed, PubMed Central
      19. Zhou W, Toki S, Zhang J, Goleniewksa K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MH, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide D, Peebles RS. Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses. Am J Respir Crit Care Med. 2016 Jan 1; 193(1):31-42. PMID: 26378386; PMCID: PMC4731613 [Available on 01/01/17].
        View in: PubMed, PubMed Central
      20. Rawson R, Anilkumar A, Newbury RO, Bafna V, Aquino M, Palmquist J, Hoffman HM, Mueller JL, Dohil R, Broide D, Aceves SS. The TGFß1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis. PLoS One. 2015; 10(12):e0144651. PMID: 26656423; PMCID: PMC4678166.
        View in: PubMed, PubMed Central
      21. Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, Song DJ, Vuong C, Doherty T, Croft M, Zuraw B, Zhang X, Gao X, Aceves S, Chouiali F, Hamid Q, Broide D. Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol. 2015 Oct 15; 195(8):3546-56. PMID: 26355153; PMCID: PMC4811198 [Available on 10/15/16].
        View in: PubMed, PubMed Central
      22. Doherty TA, Baum R, Newbury RO, Yang T, Dohil R, Aquino M, Doshi A, Walford HH, Kurten RC, Broide D, Aceves S. Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis. J Allergy Clin Immunol. 2015 Sep; 136(3):792-794.e3. PMID: 26233928; PMCID: PMC4562810.
        View in: PubMed, PubMed Central
      23. Rajan J, Newbury RO, Anilkumar A, Dohil R, Broide D, Aceves SS. Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids. J Allergy Clin Immunol. 2016 Jan; 137(1):147-156.e8. PMID: 26233926; PMCID: PMC4715736 [Available on 01/01/17].
        View in: PubMed, PubMed Central
      24. Mehta AK, Duan W, Doerner AM, Traves SL, Broide D, Proud D, Zuraw BL, Croft M. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33. J Allergy Clin Immunol. 2016 Jan; 137(1):278-288.e6. PMID: 26100084; PMCID: PMC4684822 [Available on 01/01/17].
        View in: PubMed, PubMed Central
      25. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide D, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. PMID: 25605931; PMCID: PMC4321256.
        View in: PubMed, PubMed Central
      26. Walford HH, Lund SJ, Baum RE, White AA, Bergeron CM, Husseman J, Bethel KJ, Scott DR, Khorram N, Miller M, Broide D, Doherty TA. Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness. Clin Immunol. 2014 Nov; 155(1):126-35. PMID: 25236785; PMCID: PMC4254351.
        View in: PubMed, PubMed Central
      27. Schulten V, Tripple V, Sidney J, Greenbaum J, Frazier A, Alam R, Broide D, Peters B, Sette A. Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy. J Allergy Clin Immunol. 2014 Nov; 134(5):1076-83. PMID: 25042980; PMCID: PMC4253970.
        View in: PubMed, PubMed Central
      28. Cho JY, Doshi A, Rosenthal P, Beppu A, Miller M, Aceves S, Broide D. Smad3-deficient mice have reduced esophageal fibrosis and angiogenesis in a model of egg-induced eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2014 Jul; 59(1):10-6. PMID: 24590208; PMCID: PMC4148477.
        View in: PubMed, PubMed Central
      29. Miyazaki M, Miyazaki K, Chen S, Itoi M, Miller M, Lu LF, Varki N, Chang AN, Broide D, Murre C. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Nat Immunol. 2014 Aug; 15(8):767-76. PMID: 24973820; PMCID: PMC4365819.
        View in: PubMed, PubMed Central
      30. Nonaka M, Bao X, Matsumura F, Götze S, Kandasamy J, Kononov A, Broide D, Nakayama J, Seeberger PH, Fukuda M. Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8173-8. PMID: 24835176; PMCID: PMC4050563.
        View in: PubMed, PubMed Central
      31. Beppu LY, Anilkumar AA, Newbury RO, Dohil R, Broide D, Aceves SS. TGF-ß1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Nov; 134(5):1100-1107.e4. PMID: 24835503; PMCID: PMC4231011.
        View in: PubMed, PubMed Central
      32. Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide D. ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol. 2014 Apr 15; 192(8):3475-87. PMID: 24623133; PMCID: PMC3981544.
        View in: PubMed, PubMed Central
      33. Doherty TA, Scott D, Walford HH, Khorram N, Lund S, Baum R, Chang J, Rosenthal P, Beppu A, Miller M, Broide D. Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84. J Allergy Clin Immunol. 2014 Apr; 133(4):1203-5. PMID: 24582313; PMCID: PMC3972276.
        View in: PubMed, PubMed Central
      34. Cho JY, Rosenthal P, Miller M, Pham A, Aceves S, Sakuda S, Broide D. Targeting AMCase reduces esophageal eosinophilic inflammation and remodeling in a mouse model of egg induced eosinophilic esophagitis. Int Immunopharmacol. 2014 Jan; 18(1):35-42. PMID: 24239745; PMCID: PMC3908829.
        View in: PubMed, PubMed Central
      35. Chang JE, Doherty TA, Baum R, Broide D. Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. J Allergy Clin Immunol. 2014 Mar; 133(3):899-901.e3. PMID: 24210841; PMCID: PMC3943597.
        View in: PubMed, PubMed Central
      36. Kuo YC, Li YS, Zhou J, Shih YR, Miller M, Broide D, Lee OK, Chien S. Human mesenchymal stem cells suppress the stretch-induced inflammatory miR-155 and cytokines in bronchial epithelial cells. PLoS One. 2013; 8(8):e71342. PMID: 23967196; PMCID: PMC3742760.
        View in: PubMed, PubMed Central
      37. Doherty TA, Khorram N, Lund S, Mehta AK, Croft M, Broide D. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol. 2013 Jul; 132(1):205-13. PMID: 23688412; PMCID: PMC3704056.
        View in: PubMed, PubMed Central
      38. Suzukawa M, Miller M, Rosenthal P, Cho JY, Doherty TA, Varki A, Broide D. Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. J Immunol. 2013 Jun 15; 190(12):5939-48. PMID: 23677475; PMCID: PMC3679360.
        View in: PubMed, PubMed Central
      39. Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide D, Aceves SS. Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2013 Jun; 131(6):1576-82. PMID: 23623266; PMCID: PMC3699422.
        View in: PubMed, PubMed Central
      40. Soroosh P, Doherty TA, Duan W, Mehta AK, Choi H, Adams YF, Mikulski Z, Khorram N, Rosenthal P, Broide D, Croft M. Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance. J Exp Med. 2013 Apr 08; 210(4):775-88. PMID: 23547101; PMCID: PMC3620360.
        View in: PubMed, PubMed Central
      41. Baek KJ, Cho JY, Rosenthal P, Alexander LE, Nizet V, Broide D. Hypoxia potentiates allergen induction of HIF-1a, chemokines, airway inflammation, TGF-ß1, and airway remodeling in a mouse model. Clin Immunol. 2013 Apr; 147(1):27-37. PMID: 23499929; PMCID: PMC3812068.
        View in: PubMed, PubMed Central
      42. Schulten V, Greenbaum JA, Hauser M, McKinney DM, Sidney J, Kolla R, Lindestam Arlehamn CS, Oseroff C, Alam R, Broide D, Ferreira F, Ferreira-Briza F, Grey HM, Sette A, Peters B. Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3459-64. PMID: 23401558; PMCID: PMC3587276.
        View in: PubMed, PubMed Central
      43. McKinney DM, Southwood S, Hinz D, Oseroff C, Arlehamn CS, Schulten V, Taplitz R, Broide D, Hanekom WA, Scriba TJ, Wood R, Alam R, Peters B, Sidney J, Sette A. A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population. Immunogenetics. 2013 May; 65(5):357-70. PMID: 23392739; PMCID: PMC3633633.
        View in: PubMed, PubMed Central
      44. Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide D, Nizet V. Myeloid cell HIF-1a regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013 May; 91(5):637-44. PMID: 23250618; PMCID: PMC3646920.
        View in: PubMed, PubMed Central
      45. Vaughan K, Peters B, Larche M, Pomes A, Broide D, Sette A. Strategies to query and display allergy-derived epitope data from the immune epitope database. Int Arch Allergy Immunol. 2013; 160(4):334-45. PMID: 23172234; PMCID: PMC3629817.
        View in: PubMed, PubMed Central
      46. Schulten V, Oseroff C, Alam R, Broide D, Vijayanand P, Peters B, Sette A. The identification of potentially pathogenic and therapeutic epitopes from common human allergens. Ann Allergy Asthma Immunol. 2013 Jan; 110(1):7-10. PMID: 23244651; PMCID: PMC3547526.
        View in: PubMed, PubMed Central
      47. Miller M, Tam AB, Cho JY, Doherty TA, Pham A, Khorram N, Rosenthal P, Mueller JL, Hoffman HM, Suzukawa M, Niwa M, Broide D. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16648-53. PMID: 23011799; PMCID: PMC3478632.
        View in: PubMed, PubMed Central
      48. Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide D, Matsumoto K, Nakae S. Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol. 2012 Oct 01; 189(7):3641-52. PMID: 22942422; PMCID: PMC3812057.
        View in: PubMed, PubMed Central
      49. Doherty TA, Khorram N, Chang JE, Kim HK, Rosenthal P, Croft M, Broide D. STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 01; 303(7):L577-88. PMID: 22865552; PMCID: PMC3469584.
        View in: PubMed, PubMed Central
      50. Oseroff C, Sidney J, Vita R, Tripple V, McKinney DM, Southwood S, Brodie TM, Sallusto F, Grey H, Alam R, Broide D, Greenbaum JA, Kolla R, Peters B, Sette A. T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts. J Immunol. 2012 Aug 15; 189(4):1800-11. PMID: 22786768; PMCID: PMC3411923.
        View in: PubMed, PubMed Central
      51. Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide D. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol. 2012 Mar 15; 188(6):2622-9. PMID: 22327070; PMCID: PMC3294141.
        View in: PubMed, PubMed Central
      52. Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide D, Kawakami Y, Kawakami T. Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest. 2012 Jan; 122(1):218-28. PMID: 22133880; PMCID: PMC3248297.
        View in: PubMed, PubMed Central
      53. Rubinstein E, Cho JY, Rosenthal P, Chao J, Miller M, Pham A, Aceves SS, Varki A, Broide D. Siglec-F inhibition reduces esophageal eosinophilia and angiogenesis in a mouse model of eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2011 Oct; 53(4):409-16. PMID: 21970996; PMCID: PMC3980963.
        View in: PubMed, PubMed Central
      54. Doherty TA, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho JY, Norris PS, Choi H, Scheu S, Pfeffer K, Zuraw BL, Ware CF, Broide D, Croft M. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med. 2011 May; 17(5):596-603. PMID: 21499267; PMCID: PMC3097134.
        View in: PubMed, PubMed Central
      55. Cho JY, Pham A, Rosenthal P, Miller M, Doherty T, Broide D. Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling. Int Immunopharmacol. 2011 Aug; 11(8):1038-44. PMID: 21382533; PMCID: PMC3121895.
        View in: PubMed, PubMed Central
      56. Broide D, Finkelman F, Bochner BS, Rothenberg ME. Advances in mechanisms of asthma, allergy, and immunology in 2010. J Allergy Clin Immunol. 2011 Mar; 127(3):689-95. PMID: 21377038.
        View in: PubMed
      57. Ebmeyer J, Leichtle A, Hernandez M, Ebmeyer U, Husseman J, Pak K, Sudhoff H, Broide D, Wasserman SI, Ryan AF. TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC Immunol. 2011 Jan 26; 12:12. PMID: 21269505; PMCID: PMC3040143.
        View in: PubMed, PubMed Central
      58. Yum HY, Cho JY, Miller M, Broide D. Allergen-induced coexpression of bFGF and TGF-ß1 by macrophages in a mouse model of airway remodeling: bFGF induces macrophage TGF-ß1 expression in vitro. Int Arch Allergy Immunol. 2011; 155(1):12-22. PMID: 21109744; PMCID: PMC2997445.
        View in: PubMed, PubMed Central
      59. Aceves SS, Chen D, Newbury RO, Dohil R, Bastian JF, Broide D. Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-ß1, and increase esophageal smooth muscle contraction. J Allergy Clin Immunol. 2010 Dec; 126(6):1198-204.e4. PMID: 21047675.
        View in: PubMed
      60. Cho JY, Song DJ, Pham A, Rosenthal P, Miller M, Dayan S, Doherty TA, Varki A, Broide D. Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13. Respir Res. 2010 Nov 01; 11:154. PMID: 21040544; PMCID: PMC2988013.
        View in: PubMed, PubMed Central
      61. Miller M, Cho JY, Pham A, Friedman PJ, Ramsdell J, Broide D. Persistent airway inflammation and emphysema progression on CT scan in ex-smokers observed for 4 years. Chest. 2011 Jun; 139(6):1380-1387. PMID: 20966041; PMCID: PMC3109645.
        View in: PubMed, PubMed Central
      62. Miller M, Pham A, Cho JY, Rosenthal P, Broide D. Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema. Am J Physiol Lung Cell Mol Physiol. 2010 Dec; 299(6):L834-42. PMID: 20935231; PMCID: PMC3006270.
        View in: PubMed, PubMed Central
      63. Broide D. Allergic rhinitis: Pathophysiology. Allergy Asthma Proc. 2010 Sep-Oct; 31(5):370-4. PMID: 20929602.
        View in: PubMed
      64. Oseroff C, Sidney J, Kotturi MF, Kolla R, Alam R, Broide D, Wasserman SI, Weiskopf D, McKinney DM, Chung JL, Petersen A, Grey H, Peters B, Sette A. Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol. 2010 Jul 15; 185(2):943-55. PMID: 20554959; PMCID: PMC3310373.
        View in: PubMed, PubMed Central
      65. Pae S, Cho JY, Dayan S, Miller M, Pemberton AD, Broide D. Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9. Immunogenetics. 2010 Aug; 62(8):499-506. PMID: 20480160; PMCID: PMC2910299.
        View in: PubMed, PubMed Central
      66. Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide D. Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. Int Immunopharmacol. 2010 Aug; 10(8):906-12. PMID: 20494824; PMCID: PMC2908188.
        View in: PubMed, PubMed Central
      67. Takahashi H, Ogata H, Nishigaki R, Broide D, Karin M. Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell. 2010 Jan 19; 17(1):89-97. PMID: 20129250; PMCID: PMC2818776.
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      68. Ebmeyer J, Ebmeyer U, Pak K, Sudhoff H, Broide D, Ryan AF, Wasserman S. Reconstitution of the mast cell population in W/Wv mice. Otol Neurotol. 2010 Jan; 31(1):42-7. PMID: 19752767; PMCID: PMC2796298.
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      69. Turvey SE, Broide D. Innate immunity. J Allergy Clin Immunol. 2010 Feb; 125(2 Suppl 2):S24-32. PMID: 19932920; PMCID: PMC2832725.
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      70. Song DJ, Min MG, Miller M, Cho JY, Yum HY, Broide D. Toll-like receptor-9 agonist inhibits airway inflammation, remodeling and hyperreactivity in mice exposed to chronic environmental tobacco smoke and allergen. Int Arch Allergy Immunol. 2010; 151(4):285-96. PMID: 19851071; PMCID: PMC2853586.
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      71. Song DJ, Cho JY, Lee SY, Miller M, Rosenthal P, Soroosh P, Croft M, Zhang M, Varki A, Broide D. Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. J Immunol. 2009 Oct 15; 183(8):5333-41. PMID: 19783675; PMCID: PMC2788790.
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      72. Song DJ, Min MG, Miller M, Cho JY, Broide D. Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L380-7. PMID: 19525386; PMCID: PMC2742786.
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      73. Strangman WK, Kwon HC, Broide D, Jensen PR, Fenical W. Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium. J Med Chem. 2009 Apr 23; 52(8):2317-27. PMID: 19323483; PMCID: PMC2735501.
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      74. Boyce JA, Broide D, Matsumoto K, Bochner BS. Advances in mechanisms of asthma, allergy, and immunology in 2008. J Allergy Clin Immunol. 2009 Mar; 123(3):569-74. PMID: 19281904; PMCID: PMC2671063.
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      75. Song DJ, Cho JY, Miller M, Strangman W, Zhang M, Varki A, Broide D. Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model. Clin Immunol. 2009 Apr; 131(1):157-69. PMID: 19135419; PMCID: PMC2683248.
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      76. Miller M, Cho JY, Pham A, Ramsdell J, Broide D. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol. 2009 Jan 01; 182(1):684-91. PMID: 19109202.
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      77. Broide D. Immunomodulation of allergic disease. Annu Rev Med. 2009; 60:279-91. PMID: 19630573; PMCID: PMC2779001.
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      78. Doherty TA, Soroosh P, Broide D, Croft M. CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L229-35. PMID: 19060225; PMCID: PMC2643996.
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      79. Lim DH, Cho JY, Song DJ, Lee SY, Miller M, Broide D. PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L210-9. PMID: 19028980; PMCID: PMC2643991.
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      80. Broide D. New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007. J Allergy Clin Immunol. 2008 Sep; 122(3):475-80. PMID: 18694589.
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      81. Aceves SS, Broide D. Airway fibrosis and angiogenesis due to eosinophil trafficking in chronic asthma. Curr Mol Med. 2008 Aug; 8(5):350-8. PMID: 18691061.
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      82. Fong CH, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, Karin M, Lawrence T. An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. J Exp Med. 2008 Jun 09; 205(6):1269-76. PMID: 18490491; PMCID: PMC2413025.
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      83. Broide D. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol. 2008 Mar; 121(3):560-70; quiz 571-2. PMID: 18328887; PMCID: PMC2386668.
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      84. Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide D, Tam EK. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem. 2008 Feb 29; 283(9):5760-8. PMID: 18056268.
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      85. Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck L, Elliott GI, Kufareva I, Abagyan R, Broide D, Lee J, Raz E. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18619-24. PMID: 18003900; PMCID: PMC2141826.
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      86. Miller M, Ramsdell J, Friedman PJ, Cho JY, Renvall M, Broide D. Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema. J Allergy Clin Immunol. 2007 Nov; 120(5):1118-25. PMID: 17983873.
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      87. Doherty T, Broide D. Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol. 2007 Dec; 19(6):676-80. PMID: 17720466.
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      88. Broide D. The pathophysiology of allergic rhinoconjunctivitis. Allergy Asthma Proc. 2007 Jul-Aug; 28(4):398-403. PMID: 17883906.
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      89. Le AV, Cho JY, Miller M, McElwain S, Golgotiu K, Broide D. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J Immunol. 2007 Jun 01; 178(11):7310-6. PMID: 17513781.
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      90. Min MG, Song DJ, Miller M, Cho JY, McElwain S, Ferguson P, Broide D. Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice. J Immunol. 2007 Apr 15; 178(8):5321-8. PMID: 17404317.
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      91. Zhang M, Angata T, Cho JY, Miller M, Broide D, Varki A. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood. 2007 May 15; 109(10):4280-7. PMID: 17272508; PMCID: PMC1885492.
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      92. Aceves SS, Newbury RO, Dohil R, Bastian JF, Broide D. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007 Jan; 119(1):206-12. PMID: 17208603.
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      93. Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL, Khattignavong AP, Lindblad R, Li H, Coffman R, Seyfert V, Eiden JJ, Broide D. Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med. 2006 Oct 05; 355(14):1445-55. PMID: 17021320.
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      94. Lim DH, Cho JY, Miller M, McElwain K, McElwain S, Broide D. Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L265-71. PMID: 16825657.
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      95. Cho JY, Miller M, McElwain K, McElwain S, Shim JY, Raz E, Broide D. Remodeling associated expression of matrix metalloproteinase 9 but not tissue inhibitor of metalloproteinase 1 in airway epithelium: modulation by immunostimulatory DNA. J Allergy Clin Immunol. 2006 Mar; 117(3):618-25. PMID: 16522462.
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      96. Le AV, Broide D. Indoleamine-2,3-dioxygenase modulation of allergic immune responses. Curr Allergy Asthma Rep. 2006 Feb; 6(1):27-31. PMID: 16476191.
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      97. Lee SY, Cho JY, Miller M, McElwain K, McElwain S, Sriramarao P, Raz E, Broide D. Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice. J Allergy Clin Immunol. 2006 Mar; 117(3):597-603. PMID: 16522459.
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      98. Miller M, Cho JY, McElwain K, McElwain S, Shim JY, Manni M, Baek JS, Broide D. Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice. Am J Physiol Lung Cell Mol Physiol. 2006 Jan; 290(1):L162-9. PMID: 16344333.
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      99. Broide D. Prospects for CpG based immunotherapy in asthma and allergy. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 2006; (95):217-20; discussion 220-2. PMID: 17393743.
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      100. Broide D, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17723-8. PMID: 16317067; PMCID: PMC1308936.
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      101. Cho JY, Miller M, McElwain K, McElwain S, Broide D. Combination of corticosteroid therapy and allergen avoidance reverses allergen-induced airway remodeling in mice. J Allergy Clin Immunol. 2005 Nov; 116(5):1116-22. PMID: 16275385.
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      102. Ebmeyer J, Furukawa M, Pak K, Ebmeyer U, Sudhoff H, Broide D, Ryan AF, Wasserman S. Role of mast cells in otitis media. J Allergy Clin Immunol. 2005 Nov; 116(5):1129-35. PMID: 16275387.
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      103. Broide D. Immunostimulatory sequences of DNA and conjugates in the treatment of allergic rhinitis. Curr Allergy Asthma Rep. 2005 May; 5(3):182-5. PMID: 15842954.
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      104. Hayashi T, Gong X, Rossetto C, Shen C, Takabayashi K, Redecke V, Spiegelberg H, Broide D, Raz E. Induction and inhibition of the Th2 phenotype spread: implications for childhood asthma. J Immunol. 2005 May 01; 174(9):5864-73. PMID: 15843591.
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      105. Broide D. DNA vaccines: an evolving approach to the treatment of allergic disorders. Allergy Asthma Proc. 2005 May-Jun; 26(3):195-8. PMID: 16119033.
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      106. Youn CJ, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Raz E, Broide D. Immunostimulatory DNA reverses established allergen-induced airway remodeling. J Immunol. 2004 Dec 15; 173(12):7556-64. PMID: 15585883.
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      107. Broide D. Immunomodulation and reversal of airway remodeling in asthma. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):529-32. PMID: 15640694.
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      108. Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum JL. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest. 2004 Aug; 114(3):427-37. PMID: 15286809; PMCID: PMC484976.
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      109. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide D, Carson DA, Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. PMID: 15254594; PMCID: PMC449749.
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      110. Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide D, Raz E. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol. 2004 Mar 01; 172(5):2739-43. PMID: 14978071.
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      111. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Friedman S, Broide D. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest. 2004 Feb; 113(4):551-60. PMID: 14966564; PMCID: PMC338264.
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      112. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Raz E, Broide D. Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling. Am J Respir Cell Mol Biol. 2004 May; 30(5):651-61. PMID: 14617508.
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      113. Ikeda RK, Miller M, Nayar J, Walker L, Cho JY, McElwain K, McElwain S, Raz E, Broide D. Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol. 2003 Nov 01; 171(9):4860-7. PMID: 14568966.
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      114. Sikora L, Johansson AC, Rao SP, Hughes GK, Broide D, Sriramarao P. A murine model to study leukocyte rolling and intravascular trafficking in lung microvessels. Am J Pathol. 2003 Jun; 162(6):2019-28. PMID: 12759257; PMCID: PMC1868130.
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      115. Ikeda RK, Nayar J, Cho JY, Miller M, Rodriguez M, Raz E, Broide D. Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids. Am J Respir Cell Mol Biol. 2003 Jun; 28(6):655-63. PMID: 12760963.
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      116. Hoffman HM, Gregory SG, Mueller JL, Tresierras M, Broide D, Wanderer AA, Kolodner RD. Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. Hum Genet. 2003 Feb; 112(2):209-16. PMID: 12522564.
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      117. Khaldoyanidi S, Sikora L, Broide D, Rothenberg ME, Sriramarao P. Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen. Blood. 2003 Feb 01; 101(3):863-8. PMID: 12393708.
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      118. Miller M, Cho JY, Baek KJ, Castaneda D, Nayar J, Rodriguez M, Roman M, Raz E, Broide D. Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness. Vaccine. 2002 Jul 26; 20(23-24):3023-33. PMID: 12126916.
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      119. Broide D. Fast flowing eosinophils: signals for stopping and stepping out of blood vessels. Am J Respir Cell Mol Biol. 2002 Jun; 26(6):637-40. PMID: 12034560.
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      120. Broide D, Miller M, Castaneda D, Nayar J, Cho JY, Roman M, Ellies LG, Sriramarao P. Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L259-66. PMID: 11792630.
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      121. Broide D, Stachnick G, Castaneda D, Nayar J, Miller M, Cho JY, Roman M, Zubeldia J, Hayashi T, Raz E, Hyashi T. Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma. J Clin Immunol. 2001 May; 21(3):175-82. PMID: 11403224.
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      122. Broide D, Stachnick G, Castaneda D, Nayar J, Sriramarao P. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol. 2001 Mar; 24(3):304-11. PMID: 11245629.
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      123. Broide D, Sriramarao P. Eosinophil trafficking to sites of allergic inflammation. Immunol Rev. 2001 Feb; 179:163-72. PMID: 11292020.
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      124. Broide D, Campbell K, Gifford T, Sriramarao P. Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium. Blood. 2000 Jan 01; 95(1):263-9. PMID: 10607711.
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      125. Broide D, Hoffman H, Sriramarao P. Genes that regulate eosinophilic inflammation. Am J Hum Genet. 1999 Aug; 65(2):302-7. PMID: 10417272; PMCID: PMC1377928.
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      126. Broide D, Raz E. DNA-Based immunization for asthma. Int Arch Allergy Immunol. 1999 Feb-Apr; 118(2-4):453-6. PMID: 10224473.
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      127. Broide D, Sullivan S, Gifford T, Sriramarao P. Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice. Am J Respir Cell Mol Biol. 1998 Feb; 18(2):218-25. PMID: 9476909.
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