Our site may be slower due to heavy traffic from automated "bots" and AI crawlers. We're working to fix this.

Liangfang Zhang

Title(s)Professor, Nanoengineering
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    Membrane-cloaked nanoparticles as mucosal vaccines against giardiasis
    NIH R21AI166815Sep 24, 2021 - Aug 31, 2023
    Role: Co-Principal Investigator
    Tumor-Targeted Chemo-Immunotherapy for Osteosarcoma Metastasis
    NIH R01CA200574Jun 15, 2016 - May 31, 2021
    Role: Principal Investigator
    Nanoparticle decoys for treating infections with enterotoxin-producing pathogens
    NIH R33AI121571Dec 1, 2015 - Nov 30, 2021
    Role: Co-Principal Investigator
    Nanoparticle decoys for treating infections with enterotoxin-producing pathogens
    NIH R21AI121571Dec 1, 2015 - Nov 30, 2017
    Role: Principal Investigator
    Nanotherapeutics for Ocular Infections
    NIH R01EY025947Sep 30, 2015 - Aug 31, 2019
    Role: Principal Investigator
    Innate Antimicrobial Nanotherapeutics for the Treatment of H. pylori Infection
    NIH R01DK095168Jun 1, 2012 - May 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pharmacological Mechanisms of Cellular Nanoparticles in Biological Neutralization. Annu Rev Pharmacol Toxicol. 2025 Jul 28. Sun L, Feng K, Zhang JA, Shen WT, Gao W, Zhang L. PMID: 40720705.
      View in: PubMed   Mentions:    Fields:    
    2. Robotic micromotors transforming oral drug administration. Trends Biotechnol. 2025 Sep; 43(9):2197-2213. Abbas A, Mundaca-Uribe R, Zhang L, Wang J. PMID: 40221252.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    3. Hepatic endoplasmic reticulum-derived nanodiscs for broad-spectrum drug detoxification. Biomaterials. 2025 Jul; 318:123188. Sun L, Feng K, Bai D, Yu Y, Shen WT, Zhang JA, Fang RH, Gao W, Zhang L. PMID: 39954312.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Inhalable biohybrid microrobots: a non-invasive approach for lung treatment. Nat Commun. 2025 Jan 14; 16(1):666. Li Z, Guo Z, Zhang F, Sun L, Luan H, Fang Z, Dedrick JL, Zhang Y, Tang C, Zhu A, Yu Y, Ding S, Wang D, Chang AY, Yin L, Russell LM, Gao W, Fang RH, Zhang L, Wang J. PMID: 39809831; PMCID: PMC11733022.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    5. Modular functionalization of cellular nanodiscs enables targeted delivery of chemotherapeutics into tumors. J Control Release. 2025 Feb 10; 378:145-152. Noh I, Guo Z, Wang R, Zhu AT, Krishnan N, Mohapatra A, Gao W, Fang RH, Zhang L. PMID: 39657891; PMCID: PMC11933242.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Cell membrane-coated nanoparticles for targeting carcinogenic bacteria. Adv Drug Deliv Rev. 2024 06; 209:115320. Sun L, Wang D, Feng K, Zhang JA, Gao W, Zhang L. PMID: 38643841.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Biohybrid nanoparticles for treating arthritis. Nat Nanotechnol. 2023 Dec; 18(12):1387-1388. Fang RH, Zhang L. PMID: 37884659.
      View in: PubMed   Mentions: 3     Fields:    
    8. A modular approach to enhancing cell membrane-coated nanoparticle functionality using genetic engineering. Nat Nanotechnol. 2024 Mar; 19(3):345-353. Krishnan N, Jiang Y, Zhou J, Mohapatra A, Peng FX, Duan Y, Holay M, Chekuri S, Guo Z, Gao W, Fang RH, Zhang L. PMID: 37903891; PMCID: PMC10954421.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    9. Towards multifunctional robotic pills. Nat Biomed Eng. 2024 Nov; 8(11):1334-1346. Mundaca-Uribe R, Askarinam N, Fang RH, Zhang L, Wang J. PMID: 37723325.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    10. Glycan-modified cellular nanosponges for enhanced neutralization of botulinum toxin. Biomaterials. 2023 11; 302:122330. Ai X, Wang D, Noh I, Duan Y, Zhou Z, Mukundan N, Fang RH, Gao W, Zhang L. PMID: 37742508.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Designs of metal-organic framework nanoparticles for protein delivery. J Control Release. 2023 09; 361:178-190. Kai M, Wang S, Gao W, Zhang L. PMID: 37532146.
      View in: PubMed   Mentions: 5     Fields:    
    12. Inhalable mRNA nanoparticles. Nat Mater. 2023 Mar; 22(3):278-279. Fang RH, Zhang L. PMID: 36864158.
      View in: PubMed   Mentions: 1     Fields:    
    13. Genetically engineered cellular nanoparticles for biomedical applications. Biomaterials. 2023 05; 296:122065. Krishnan N, Peng FX, Mohapatra A, Fang RH, Zhang L. PMID: 36841215; PMCID: PMC10542936.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    14. Targeting drugs to tumours using cell membrane-coated nanoparticles. Nat Rev Clin Oncol. 2023 01; 20(1):33-48. Fang RH, Gao W, Zhang L. PMID: 36307534.
      View in: PubMed   Mentions: 224     Fields:    Translation:HumansCells
    15. Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia. Nat Mater. 2022 11; 21(11):1324-1332. Zhang F, Zhuang J, Li Z, Gong H, de Ávila BE, Duan Y, Zhang Q, Zhou J, Yin L, Karshalev E, Gao W, Nizet V, Fang RH, Zhang L, Wang J. PMID: 36138145; PMCID: PMC9633541.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    16. Bacterial membrane vesicles for vaccine applications. Adv Drug Deliv Rev. 2022 06; 185:114294. Krishnan N, Kubiatowicz LJ, Holay M, Zhou J, Fang RH, Zhang L. PMID: 35436569.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    17. Engineering of stimuli-responsive self-assembled biomimetic nanoparticles. Adv Drug Deliv Rev. 2021 12; 179:114006. Krishnan N, Fang RH, Zhang L. PMID: 34655662.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    18. Nanodelivery of STING agonists against cancer and infectious diseases. Mol Aspects Med. 2022 02; 83:101007. Zhou J, Ventura CJ, Fang RH, Zhang L. PMID: 34353637; PMCID: PMC8792206.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis. Nat Commun. 2021 07 06; 12(1):4136. Zhang Q, Zhou J, Zhou J, Fang RH, Gao W, Zhang L. PMID: 34230486; PMCID: PMC8260623.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    20. Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs. Sci Adv. 2021 06; 7(25). Park JH, Jiang Y, Zhou J, Gong H, Mohapatra A, Heo J, Gao W, Fang RH, Zhang L. PMID: 34134990; PMCID: PMC8208717.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    21. Nanomaterials arising amid antibiotic resistance. Nat Rev Microbiol. 2021 01; 19(1):5-6. Gao W, Zhang L. PMID: 33024312; PMCID: PMC7538279.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    22. Enzyme-powered Janus platelet cell robots for active and targeted drug delivery. Sci Robot. 2020 06 10; 5(43). Tang S, Zhang F, Gong H, Wei F, Zhuang J, Karshalev E, Esteban-Fernández de Ávila B, Huang C, Zhou Z, Li Z, Yin L, Dong H, Fang RH, Zhang X, Zhang L, Wang J. PMID: 33022613.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    23. Nanoparticle-hydrogel superstructures for biomedical applications. J Control Release. 2020 08 10; 324:505-521. Jiang Y, Krishnan N, Heo J, Fang RH, Zhang L. PMID: 32464152; PMCID: PMC7429280.
      View in: PubMed   Mentions: 74     Fields:    
    24. Engineering biological interactions on the nanoscale. Curr Opin Biotechnol. 2019 08; 58:1-8. Jiang Y, Chekuri S, Fang RH, Zhang L. PMID: 30390535; PMCID: PMC6494728.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    25. Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis. Nat Nanotechnol. 2018 12; 13(12):1182-1190. Zhang Q, Dehaini D, Zhang Y, Zhou J, Chen X, Zhang L, Fang RH, Gao W, Zhang L. PMID: 30177807.
      View in: PubMed   Mentions: 290     Fields:    Translation:HumansAnimalsCells
    26. Hybrid biomembrane-functionalized nanorobots for concurrent removal of pathogenic bacteria and toxins. Sci Robot. 2018 05 30; 3(18). Esteban-Fernández de Ávila B, Angsantikul P, Ramírez-Herrera DE, Soto F, Teymourian H, Dehaini D, Chen Y, Zhang L, Wang J. PMID: 33141704.
      View in: PubMed   Mentions: 67     Fields:    
    27. Optical detection of abnormal skin scarring. Nat Biomed Eng. 2018 04; 2(4):201-202. Fang RH, Zhang L. PMID: 30936444.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Ultrasound-propelled nanowire motors enhance asparaginase enzymatic activity against cancer cells. Nanoscale. 2017 Nov 30; 9(46):18423-18429. Uygun M, Jurado-Sánchez B, Uygun DA, Singh VV, Zhang L, Wang J. PMID: 29148558.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    29. Author correction: Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. Nat Commun. 2017 10 31; 8(1):1299. de Ávila BE, Angsantikul P, Li J, Angel Lopez-Ramirez M, Ramírez-Herrera DE, Thamphiwatana S, Chen C, Delezuk J, Samakapiruk R, Ramez V, Obonyo M, Zhang L, Wang J. PMID: 29089506; PMCID: PMC5663909.
      View in: PubMed   Mentions: 1     Fields:    
    30. Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11488-11493. Thamphiwatana S, Angsantikul P, Escajadillo T, Zhang Q, Olson J, Luk BT, Zhang S, Fang RH, Gao W, Nizet V, Zhang L. PMID: 29073076; PMCID: PMC5664555.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    31. Fabrication and characterization of a 3D bioprinted nanoparticle-hydrogel hybrid device for biomimetic detoxification. Nanoscale. 2017 Oct 05; 9(38):14506-14511. Chen MS, Zhang Y, Zhang L. PMID: 28930358.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    32. Nanoparticle-based local antimicrobial drug delivery. Adv Drug Deliv Rev. 2018 03 01; 127:46-57. Gao W, Chen Y, Zhang Y, Zhang Q, Zhang L. PMID: 28939377; PMCID: PMC5860926.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    33. Targeting and isolation of cancer cells using micro/nanomotors. Adv Drug Deliv Rev. 2018 02 01; 125:94-101. Gao W, de Ávila BE, Zhang L, Wang J. PMID: 28893551; PMCID: PMC5844782.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    34. A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery. J Control Release. 2017 Oct 28; 264:102-111. Chai Z, Hu X, Wei X, Zhan C, Lu L, Jiang K, Su B, Ruan H, Ran D, Fang RH, Zhang L, Lu W. PMID: 28842313.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    35. Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. Nat Commun. 2017 08 16; 8(1):272. de Ávila BE, Angsantikul P, Li J, Angel Lopez-Ramirez M, Ramírez-Herrera DE, Thamphiwatana S, Chen C, Delezuk J, Samakapiruk R, Ramez V, Obonyo M, Zhang L, Wang J. PMID: 28814725; PMCID: PMC5559609.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    36. Cell membrane-derived nanomaterials for biomedical applications. Biomaterials. 2017 06; 128:69-83. Fang RH, Jiang Y, Fang JC, Zhang L. PMID: 28292726; PMCID: PMC5417338.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    37. Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection. J Control Release. 2017 Oct 10; 263:185-191. Zhang Y, Zhang J, Chen W, Angsantikul P, Spiekermann KA, Fang RH, Gao W, Zhang L. PMID: 28087406; PMCID: PMC5503807.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    38. Ultra-small lipid-polymer hybrid nanoparticles for tumor-penetrating drug delivery. Nanoscale. 2016 Aug 14; 8(30):14411-9. Dehaini D, Fang RH, Luk BT, Pang Z, Hu CM, Kroll AV, Yu CL, Gao W, Zhang L. PMID: 27411852; PMCID: PMC4977227.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    39. Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function. Nanoscale. 2016 May 21; 8(19):10364-70. Chen W, Zhang Q, Luk BT, Fang RH, Liu Y, Gao W, Zhang L. PMID: 27139582; PMCID: PMC4866884.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    40. Nanoparticle-Based Modulation of the Immune System. Annu Rev Chem Biomol Eng. 2016 Jun 07; 7:305-26. Fang RH, Zhang L. PMID: 27146556.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    41. Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery. Ann Biomed Eng. 2016 06; 44(6):2049-61. Gao W, Zhang Y, Zhang Q, Zhang L. PMID: 26951462; PMCID: PMC4880511.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimals
    42. Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform. Vaccines (Basel). 2015 Oct 06; 3(4):814-28. Angsantikul P, Thamphiwatana S, Gao W, Zhang L. PMID: 26457720; PMCID: PMC4693220.
      View in: PubMed   Mentions: 19  
    43. Current and forthcoming approaches for systemic detoxification. Adv Drug Deliv Rev. 2015 Aug 01; 90:1-2. Zhang L, Leroux JC. PMID: 26298477.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    44. RBC micromotors carrying multiple cargos towards potential theranostic applications. Nanoscale. 2015 Aug 28; 7(32):13680-6. Wu Z, Esteban-Fernández de Ávila B, Martín A, Christianson C, Gao W, Thamphiwatana SK, Escarpa A, He Q, Zhang L, Wang J. PMID: 26214151.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    45. Cell membrane-camouflaged nanoparticles for drug delivery. J Control Release. 2015 Dec 28; 220(Pt B):600-7. Luk BT, Zhang L. PMID: 26210440; PMCID: PMC4688192.
      View in: PubMed   Mentions: 199     Fields:    Translation:HumansAnimalsCells
    46. Engineered nanoparticles mimicking cell membranes for toxin neutralization. Adv Drug Deliv Rev. 2015 Aug 01; 90:69-80. Fang RH, Luk BT, Hu CM, Zhang L. PMID: 25868452; PMCID: PMC4547889.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    47. Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles. Breast Cancer Res. 2015 Mar 31; 17:48. Campbell DF, Saenz R, Bharati IS, Seible D, Zhang L, Esener S, Messmer B, Larsson M, Messmer D. PMID: 25882711; PMCID: PMC4407876.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    48. In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):17600-5. Thamphiwatana S, Gao W, Obonyo M, Zhang L. PMID: 25422427; PMCID: PMC4267350.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    49. Clearance of pathological antibodies using biomimetic nanoparticles. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13481-6. Copp JA, Fang RH, Luk BT, Hu CM, Gao W, Zhang K, Zhang L. PMID: 25197051; PMCID: PMC4169917.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    50. Combinatorial nanotherapeutics: rewiring, then killing, cancer cells. Sci Signal. 2014 May 13; 7(325):pe13. Fang RH, Zhang L. PMID: 24825918.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    51. Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies. Nanoscale. 2014 Jan 07; 6(1):65-75. Hu CM, Fang RH, Luk BT, Zhang L. PMID: 24280870.
      View in: PubMed   Mentions: 67     Fields:    
    52. Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles. Nanoscale. 2013 Oct 07; 5(19):8884-8. Fang RH, Hu CM, Chen KN, Luk BT, Carpenter CW, Gao W, Li S, Zhang DE, Lu W, Zhang L. PMID: 23907698; PMCID: PMC3831007.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    53. Development of nanoparticles for antimicrobial drug delivery. Curr Med Chem. 2010; 17(6):585-94. Zhang L, Pornpattananangku D, Hu CM, Huang CM. PMID: 20015030.
      View in: PubMed   Mentions: 184     Fields:    
    Liangfang's Networks
    Concepts (201)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (8)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-16-gff1bd585 on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California