Elizabeth Brunk

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Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. Nature. 2019 05; 569(7757):570-575. Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS. PMID: 31019297; PMCID: PMC7138021.

View in: PubMed Mentions: 72 Fields:
Sci Science
Translation:Humans Animals Cells
Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):11096-11101. Brunk E, Chang RL, Xia J, Hefzi H, Yurkovich JT, Kim D, Buckmiller E, Wang HH, Cho BK, Yang C, Palsson BO, Church GM, Lewis NE. PMID: 30301795; PMCID: PMC6205427.

View in: PubMed Mentions: 15 Fields:
Sci Science
Translation:Cells
Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism. Nat Commun. 2018 09 18; 9(1):3796. McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. PMID: 30228271; PMCID: PMC6143558.

View in: PubMed Mentions: 23 Fields:
Bio Biology Sci Science
Translation:Cells
Multiple Optimal Phenotypes Overcome Redox and Glycolytic Intermediate Metabolite Imbalances in Escherichia coli pgi Knockout Evolutions. Appl Environ Microbiol. 2018 10 01; 84(19). McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. PMID: 30054360; PMCID: PMC6146989.

View in: PubMed Mentions: 9 Fields:
Mic Microbiology
Translation:Cells
Growth Adaptation of gnd and sdhCB Escherichia coli Deletion Strains Diverges From a Similar Initial Perturbation of the Transcriptome. Front Microbiol. 2018; 9:1793. McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. PMID: 30131786; PMCID: PMC6090065.

View in: PubMed Mentions: 11
ssbio: a Python framework for structural systems biology. Bioinformatics. 2018 06 15; 34(12):2155-2157. Mih N, Brunk E, Chen K, Catoiu E, Sastry A, Kavvas E, Monk JM, Zhang Z, Palsson BO. PMID: 29444205; PMCID: PMC6658713.

View in: PubMed Mentions: 18 Fields:
Com Computational Biology
Translation:Cells
Adaptive laboratory evolution resolves energy depletion to maintain high aromatic metabolite phenotypes in Escherichia coli strains lacking the Phosphotransferase System. Metab Eng. 2018 07; 48:233-242. McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. PMID: 29906504.

View in: PubMed Mentions: 13 Fields:
Bio Biomedical Engineering Met Metabolism
Translation:Cells
Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes. Metab Eng. 2018 07; 48:82-93. McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. PMID: 29842925.

View in: PubMed Mentions: 18 Fields:
Bio Biomedical Engineering Met Metabolism
Translation:Cells
Recon3D enables a three-dimensional view of gene variation in human metabolism. Nat Biotechnol. 2018 03; 36(3):272-281. Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Dräger A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlic A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO. PMID: 29457794; PMCID: PMC5840010.

View in: PubMed Mentions: 205 Fields:
Bio Biotechnology
Translation:Humans
Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework. Genome Med. 2017 Dec 18; 9(1):113. Glusman G, Rose PW, Prlic A, Dougherty J, Duarte JM, Hoffman AS, Barton GJ, Bendixen E, Bergquist T, Bock C, Brunk E, Buljan M, Burley SK, Cai B, Carter H, Gao J, Godzik A, Heuer M, Hicks M, Hrabe T, Karchin R, Leman JK, Lane L, Masica DL, Mooney SD, Moult J, Omenn GS, Pearl F, Pejaver V, Reynolds SM, Rokem A, Schwede T, Song S, Tilgner H, Valasatava Y, Zhang Y, Deutsch EW. PMID: 29254494; PMCID: PMC5735928.

View in: PubMed Mentions: 31 Fields:
Gen Genetics
Translation:Humans Cells
iML1515, a knowledgebase that computes Escherichia coli traits. Nat Biotechnol. 2017 10 11; 35(10):904-908. Monk JM, Lloyd CJ, Brunk E, Mih N, Sastry A, King Z, Takeuchi R, Nomura W, Zhang Z, Mori H, Feist AM, Palsson BO. PMID: 29020004; PMCID: PMC6521705.

View in: PubMed Mentions: 144 Fields:
Bio Biotechnology
Translation:Cells
Machine learning in computational biology to accelerate high-throughput protein expression. Bioinformatics. 2017 Aug 15; 33(16):2487-2495. Sastry A, Monk J, Tegel H, Uhlen M, Palsson BO, Rockberg J, Brunk E. PMID: 28398465; PMCID: PMC5870730.

View in: PubMed Mentions: 2 Fields:
Com Computational Biology
Translation:Humans Cells
The Need for Integrated Approaches in Metabolic Engineering. Cold Spring Harb Perspect Biol. 2016 Nov 01; 8(11). Lechner A, Brunk E, Keasling JD. PMID: 27527588; PMCID: PMC5088530.

View in: PubMed Mentions: 15 Fields:
Bio Biology
Translation:Cells
Multi-omic data integration enables discovery of hidden biological regularities. Nat Commun. 2016 10 26; 7:13091. Ebrahim A, Brunk E, Tan J, O'Brien EJ, Kim D, Szubin R, Lerman JA, Lechner A, Sastry A, Bordbar A, Feist AM, Palsson BO. PMID: 27782110; PMCID: PMC5095171.

View in: PubMed Mentions: 59 Fields:
Bio Biology Sci Science
Translation:Cells
Genetic-Algorithm-Based Optimization of a Peptidic Scaffold for Sequestration and Hydration of CO2. Chemphyschem. 2016 Dec 05; 17(23):3831-3835. Brunk E, Perez MA, Athri P, Rothlisberger U. PMID: 27706880.

View in: PubMed Mentions: 1 Fields:
Bio Biophysics Che Chemistry Phy Physics
Translation:Cells
A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism. PLoS Comput Biol. 2016 07; 12(7):e1005039. Mih N, Brunk E, Bordbar A, Palsson BO. PMID: 27467583; PMCID: PMC4965186.

View in: PubMed Mentions: 6 Fields:
Com Computational Biology
Translation:Humans Cells
Characterizing Strain Variation in Engineered E. coli Using a Multi-Omics-Based Workflow. Cell Syst. 2016 05 25; 2(5):335-46. Brunk E, George KW, Alonso-Gutierrez J, Thompson M, Baidoo E, Wang G, Petzold CJ, McCloskey D, Monk J, Yang L, O'Brien EJ, Batth TS, Martin HG, Feist A, Adams PD, Keasling JD, Palsson BO, Lee TS. PMID: 27211860; PMCID: PMC4882250.

View in: PubMed Mentions: 27 Fields:
Cel Cell Biology Com Computational Biology Mol Molecular Biology
Translation:Cells
Systems biology of the structural proteome. BMC Syst Biol. 2016 Mar 11; 10:26. Brunk E, Mih N, Monk J, Zhang Z, O'Brien EJ, Bliven SE, Chen K, Chang RL, Bourne PE, Palsson BO. PMID: 26969117; PMCID: PMC4787049.

View in: PubMed Mentions: 26 Fields:
Com Computational Biology
Translation:Cells
Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC. Front Microbiol. 2015; 6:958. Aziz RK, Khaw VL, Monk JM, Brunk E, Lewis R, Loh SI, Mishra A, Nagle AA, Satyanarayana C, Dhakshinamoorthy S, Luche M, Kitchen DB, Andrews KA, Palsson B?, Charusanti P. PMID: 26441892; PMCID: PMC4585216.

View in: PubMed Mentions: 2
A streamlined ribosome profiling protocol for the characterization of microorganisms. Biotechniques. 2015 Jun; 58(6):329-32. Latif H, Szubin R, Tan J, Brunk E, Lechner A, Zengler K, Palsson BO. PMID: 26054770.

View in: PubMed Mentions: 22 Fields:
Bio Biotechnology
Translation:Cells
Mixed Quantum Mechanical/Molecular Mechanical Molecular Dynamics Simulations of Biological Systems in Ground and Electronically Excited States. Chem Rev. 2015 Jun 24; 115(12):6217-63. Brunk E, Rothlisberger U. PMID: 25880693.

View in: PubMed Mentions: 78 Fields:
Che Chemistry
Translation:Cells
Free-energy landscape and characteristic forces for the initiation of DNA unzipping. Biophys J. 2015 Apr 07; 108(7):1727-1738. Mentes A, Florescu AM, Brunk E, Wereszczynski J, Joyeux M, Andricioaei I. PMID: 25863064; PMCID: PMC4390814.

View in: PubMed Mentions: 1 Fields:
Bio Biophysics
Translation:Cells
Model-driven discovery of underground metabolic functions in Escherichia coli. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):929-34. Guzm?n GI, Utrilla J, Nurk S, Brunk E, Monk JM, Ebrahim A, Palsson BO, Feist AM. PMID: 25564669; PMCID: PMC4311852.

View in: PubMed Mentions: 36 Fields:
Sci Science
Translation:Cells
Lessons from nature: computational design of biomimetic compounds and processes. Chimia (Aarau). 2014 Sep; 68(9):642-7. Bozkurt E, Ashari N, Browning N, Brunk E, Campomanesa P, Perez MA, Rothlisberger U. PMID: 25437785.

View in: PubMed Mentions: 1 Fields:
Che Chemistry
Translation:Humans Cells
A mechanochemical switch to control radical intermediates. Biochemistry. 2014 Jun 17; 53(23):3830-8. Brunk E, Kellett WF, Richards NG, Rothlisberger U. PMID: 24846280; PMCID: PMC4067147.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Cells
Mechanism to trigger unfolding in O(6) -alkylguanine-DNA alkyltransferase. Chembiochem. 2013 Apr 15; 14(6):703-10. Brunk E, Mollwitz B, Rothlisberger U. PMID: 23532906.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Humans Cells
Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase. Biochemistry. 2013 Mar 19; 52(11):1842-4. Kellett WF, Brunk E, Desai BJ, Fedorov AA, Almo SC, Gerlt JA, Rothlisberger U, Richards NG. PMID: 23452154; PMCID: PMC3788570.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Cells
Role of environment for catalysis of the DNA repair enzyme MutY. J Am Chem Soc. 2012 May 23; 134(20):8608-16. Brunk E, Arey JS, Rothlisberger U. PMID: 22537339.

View in: PubMed Mentions: 6 Fields:
Che Chemistry
Translation:Cells
Directed evolution of the suicide protein O6-alkylguanine-DNA alkyltransferase for increased reactivity results in an alkylated protein with exceptional stability. Biochemistry. 2012 Feb 07; 51(5):986-94. Mollwitz B, Brunk E, Schmitt S, Pojer F, Bannwarth M, Schiltz M, Rothlisberger U, Johnsson K. PMID: 22280500.

View in: PubMed Mentions: 27 Fields:
Bio Biochemistry
Translation:Humans Cells
Integrating computational methods to retrofit enzymes to synthetic pathways. Biotechnol Bioeng. 2012 Feb; 109(2):572-82. Brunk E, Neri M, Tavernelli I, Hatzimanikatis V, Rothlisberger U. PMID: 21928337.

View in: PubMed Mentions: 8 Fields:
Bio Biomedical Engineering Bio Biotechnology
Translation:Cells
Pushing the frontiers of first-principles based computer simulations of chemical and biological systems. Chimia (Aarau). 2011; 65(9):667-71. Brunk E, Ashari N, Athri P, Campomanes P, de Carvalho FF, Curchod BF, Diamantis P, Doemer M, Garrec J, Laktionov A, Micciarelli M, Neri M, Palermo G, Penfold TJ, Vanni S, Tavernelli I, Rothlisberger U. PMID: 22026176.

View in: PubMed Mentions: 7 Fields:
Che Chemistry
Translation:Cells