Mark Herzik

Title(s)Assistant Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-6653-6682 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Scripps Research Institute, La Jolla, CA12/2018Biophysics/Electron Microscopy
    University of California, Berkeley, Berkeley, CAPh.D.05/2014Molecular and Cell Biology
    University of Houston, Houston, TXB.S.05/2007Biochemical and Biophysical Sciences
    Collapse Awards and Honors
    University of California, San Diego2020  - 2023Searle Scholars Program
    Scripps Research Institute2016  - 2019Helen Hay Whitney Foundation Postdoctoral Fellow
    University of California, Berkeley2011  - 2013American Heart Association Predoctoral Fellow

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    cryoEDU: An online curriculum and software platform for hands-on learning in single-particle cryoEM and cryoET
    NIH R25EY032739Jul 1, 2021 - Jun 30, 2024
    Role: Co-Principal Investigator
    Towards an Atomistic Understanding of Mitochondrial Protein Biogenesis
    NIH R35GM138206Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Preparation of oxygen-sensitive proteins for high-resolution cryoEM structure determination using (an)aerobic blot-free vitrification. bioRxiv. 2024 Jul 22. Cook BD, Narehood SM, McGuire KL, Li Y, Tezcan FA, Herzik MA. PMID: 39091810; PMCID: PMC11291078.
      View in: PubMed   Mentions:
    2. Structural insights into GrpEL1-mediated nucleotide and substrate release of human mitochondrial Hsp70. bioRxiv. 2024 May 13. Morizono MA, McGuire KL, Birouty NI, Herzik MA. PMID: 38798347; PMCID: PMC11118385.
      View in: PubMed   Mentions:
    3. Tuning ice thickness using the chameleon for high-quality cryoEM data collection. bioRxiv. 2024 May 04. McGuire KL, Cook BD, Narehood SM, Herzik MA. PMID: 38746094; PMCID: PMC11092644.
      View in: PubMed   Mentions:
    4. Machine learning approaches to cryoEM density modification differentially affect biomacromolecule and ligand density quality. Front Mol Biosci. 2024; 11:1404885. Berkeley RF, Cook BD, Herzik MA. PMID: 38698773; PMCID: PMC11063317.
      View in: PubMed   Mentions: 1  
    5. The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA. Mol Cell. 2022 11 03; 82(21):4145-4159.e7. Deep A, Gu Y, Gao YQ, Ego KM, Herzik MA, Zhou H, Corbett KD. PMID: 36206765; PMCID: PMC9637719.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    6. Structures of the nitrogenase complex prepared under catalytic turnover conditions. Science. 2022 08 19; 377(6608):865-869. Rutledge HL, Cook BD, Nguyen HPM, Herzik MA, Tezcan FA. PMID: 35901182; PMCID: PMC9949965.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    7. Electron counting takes microED to the next level. Nat Methods. 2022 06; 19(6):652-653. Corbett KD, Herzik MA. PMID: 35637309.
      View in: PubMed   Mentions:    Fields:    
    8. Manual Blot-and-Plunge Freezing of Biological Specimens for Single-Particle Cryogenic Electron Microscopy. J Vis Exp. 2022 02 07; (180). Nguyen HPM, McGuire KL, Cook BD, Herzik MA. PMID: 35188117.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    9. Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge. Nat Methods. 2021 02; 18(2):156-164. Lawson CL, Kryshtafovych A, Adams PD, Afonine PV, Baker ML, Barad BA, Bond P, Burnley T, Cao R, Cheng J, Chojnowski G, Cowtan K, Dill KA, DiMaio F, Farrell DP, Fraser JS, Herzik MA, Hoh SW, Hou J, Hung LW, Igaev M, Joseph AP, Kihara D, Kumar D, Mittal S, Monastyrskyy B, Olek M, Palmer CM, Patwardhan A, Perez A, Pfab J, Pintilie GD, Richardson JS, Rosenthal PB, Sarkar D, Schäfer LU, Schmid MF, Schröder GF, Shekhar M, Si D, Singharoy A, Terashi G, Terwilliger TC, Vaiana A, Wang L, Wang Z, Wankowicz SA, Williams CJ, Winn M, Wu T, Yu X, Zhang K, Berman HM, Chiu W. PMID: 33542514; PMCID: PMC7864804.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    10. Setting Up Parallel Illumination on the Talos Arctica for High-Resolution Data Collection. Methods Mol Biol. 2021; 2215:125-144. Herzik MA. PMID: 33368002.
      View in: PubMed   Mentions: 9     Fields:    
    11. Cryo-electron microscopy reaches atomic resolution. Nature. 2020 11; 587(7832):39-40. Herzik MA. PMID: 33087866.
      View in: PubMed   Mentions: 11     Fields:    
    12. Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200 keV. J Struct Biol X. 2020; 4:100020. Wu M, Lander GC, Herzik MA. PMID: 32647824; PMCID: PMC7337053.
      View in: PubMed   Mentions: 31  
    13. High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM. Nat Commun. 2019 03 04; 10(1):1032. Herzik MA, Wu M, Lander GC. PMID: 30833564; PMCID: PMC6399227.
      View in: PubMed   Mentions: 95     Fields:    Translation:Cells
    14. A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality. Structure. 2019 02 05; 27(2):344-358.e3. Herzik MA, Fraser JS, Lander GC. PMID: 30449687; PMCID: PMC6365196.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    15. Conformational ensemble of the human TRPV3 ion channel. Nat Commun. 2018 11 14; 9(1):4773. Zubcevic L, Herzik MA, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY. PMID: 30429472; PMCID: PMC6235889.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    16. Cryo-EM structure of a mitochondrial calcium uniporter. Science. 2018 08 03; 361(6401):506-511. Yoo J, Wu M, Yin Y, Herzik MA, Lander GC, Lee SY. PMID: 29954988; PMCID: PMC6155975.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    17. Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity. Haematologica. 2018 06; 103(6):1073-1082. Kurakula K, Koenis DS, Herzik MA, Liu Y, Craft JW, van Loenen PB, Vos M, Tran MK, Versteeg HH, Goumans MTH, Ruf W, de Vries CJM, Sen M. PMID: 29545340; PMCID: PMC6058786.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    18. Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature. 2017 10 19; 550(7676):411-414. Hirschi M, Herzik MA, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY. PMID: 29019979; PMCID: PMC5762132.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    19. Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV. Nat Methods. 2017 Nov; 14(11):1075-1078. Herzik MA, Wu M, Lander GC. PMID: 28991891; PMCID: PMC5679434.
      View in: PubMed   Mentions: 75     Fields:    
    20. Regulation of nitric oxide signaling by formation of a distal receptor-ligand complex. Nat Chem Biol. 2017 Dec; 13(12):1216-1221. Guo Y, Suess DLM, Herzik MA, Iavarone AT, Britt RD, Marletta MA. PMID: 28967923; PMCID: PMC5698159.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    21. Nitric Oxide-Induced Conformational Changes Govern H-NOX and Histidine Kinase Interaction and Regulation in Shewanella oneidensis. Biochemistry. 2017 03 07; 56(9):1274-1284. Rao M, Herzik MA, Iavarone AT, Marletta MA. PMID: 28170222.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    22. Cryo-electron microscopy structure of the TRPV2 ion channel. Nat Struct Mol Biol. 2016 Feb; 23(2):180-186. Zubcevic L, Herzik MA, Chung BC, Liu Z, Lander GC, Lee SY. PMID: 26779611; PMCID: PMC4876856.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    23. Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. Elife. 2016 Jan 08; 5:e13027. Dambacher CM, Worden EJ, Herzik MA, Martin A, Lander GC. PMID: 26744777; PMCID: PMC4749569.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    24. Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):E4156-64. Herzik MA, Jonnalagadda R, Kuriyan J, Marletta MA. PMID: 25253889; PMCID: PMC4210026.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    25. Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):E881-9. Winter MB, Herzik MA, Kuriyan J, Marletta MA. PMID: 21997213; PMCID: PMC3203760.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    26. Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans. Biochemistry. 2010 Jul 13; 49(27):5662-70. Yoon J, Herzik MA, Winter MB, Tran R, Olea C, Marletta MA. PMID: 20518498; PMCID: PMC2903878.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    27. Structural insights into the molecular mechanism of H-NOX activation. Protein Sci. 2010 Apr; 19(4):881-7. Olea C, Herzik MA, Kuriyan J, Marletta MA. PMID: 20162612; PMCID: PMC2867026.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    28. Spectroscopic Characterization of Successive Phosphorylation of the Tissue Factor Cytoplasmic Region. Open Spectrosc J. 2009 Jan 01; 3:58-64. Sen M, Herzik M, Craft JW, Creath AL, Agrawal S, Ruf W, Legge GB. PMID: 20076769; PMCID: PMC2805860.
      View in: PubMed   Mentions: 8  
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