Loading...

Milton Saier

TitleResearcher
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0116
La Jolla CA 92093
Phone858-534-4084
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Integrative functional mapping of the Escherichia coli membrane interactome
    NIH/NIGMS R01GM109895Sep 5, 2014 - Jul 31, 2018
    Role: Principal Investigator
    TransportPDB: Center for the X-ray Structure Determination of Human Transporters
    NIH/NIGMS U54GM094610Sep 30, 2010 - Jun 30, 2015
    Role: Co-Investigator
    The Transporter Classification Database (TCDB)
    NIH/NIGMS R01GM077402Apr 1, 2006 - Feb 28, 2019
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    ATP-Dependent Protein Kinases in Gram-Positive Bacteria
    NIH/NIGMS R01GM055434Dec 1, 1984 - Jun 30, 2006
    Role: Principal Investigator
    ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
    NIH/NIAID R01AI021702Dec 1, 1984 - Nov 30, 1996
    Role: Principal Investigator
    FUNCTION AND CONTROL OF A KIDNEY EPITHELIAL CELL LINE
    NIH/NIADDK R01AM021994Jul 1, 1979 - Mar 31, 1986
    Role: Principal Investigator
    Mechanism of Carbohydrate Transport in Bacteria
    NIH/NIGMS R01GM064368Sep 1, 1977 - Mar 31, 2006
    Role: Principal Investigator
    MECHANISM OF CARBOHYDRATE TRANSPORT IN BACTERIA
    NIH/NIAID R01AI014176Sep 1, 1977 - Mar 31, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Medrano-Soto A, Moreno-Hagelsieb G, McLaughlin D, Ye ZS, Hendargo KJ, Saier M. Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases. PLoS One. 2018; 13(3):e0192851. PMID: 29579047.
      View in: PubMed
    2. Rodionova IA, Goodacre N, Babu M, Emili A, Uetz P, Saier M. The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli. J Bacteriol. 2018 Mar 01; 200(5). PMID: 29229699.
      View in: PubMed
    3. Heidari Tajabadi F, Medrano-Soto A, Ahmadzadeh M, Salehi Jouzani G, Saier M. Comparative Analyses of Transport Proteins Encoded within the Genomes of Bdellovibrio bacteriovorus HD100 and Bdellovibrio exovorus JSS. J Mol Microbiol Biotechnol. 2017; 27(6):332-349. PMID: 29212086.
      View in: PubMed
    4. Babu M, Bundalovic-Torma C, Calmettes C, Phanse S, Zhang Q, Jiang Y, Minic Z, Kim S, Mehla J, Gagarinova A, Rodionova I, Kumar A, Guo H, Kagan O, Pogoutse O, Aoki H, Deineko V, Caufield JH, Holtzapple E, Zhang Z, Vastermark A, Pandya Y, Lai CC, El Bakkouri M, Hooda Y, Shah M, Burnside D, Hooshyar M, Vlasblom J, Rajagopala SV, Golshani A, Wuchty S, F Greenblatt J, Saier M, Uetz P, F Moraes T, Parkinson J, Emili A. Global landscape of cell envelope protein complexes in Escherichia coli. Nat Biotechnol. 2018 Jan; 36(1):103-112. PMID: 29176613.
      View in: PubMed
    5. Moreno-Hagelsieb G, Vitug B, Medrano-Soto A, Saier M. The Membrane Attack Complex/Perforin Superfamily. J Mol Microbiol Biotechnol. 2017; 27(4):252-267. PMID: 29145176.
      View in: PubMed
    6. Humayun MZ, Zhang Z, Butcher AM, Moshayedi A, Saier M. Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. PLoS One. 2017; 12(6):e0180156. PMID: 28666002.
      View in: PubMed
    7. Rodionova IA, Zhang Z, Mehla J, Goodacre N, Babu M, Emili A, Uetz P, Saier M. The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli. J Biol Chem. 2017 08 25; 292(34):14250-14257. PMID: 28634232.
      View in: PubMed
    8. Saier M, Trevors JT. Science, Innovation and the Future of Humanity. J Mol Microbiol Biotechnol. 2017; 27(2):128-132. PMID: 28448972.
      View in: PubMed
    9. Lee J, Ghosh S, Saier M. Comparative genomic analyses of transport proteins encoded within the red algae Chondrus crispus, Galdieria sulphuraria, and Cyanidioschyzon merolae11. J Phycol. 2017 Jun; 53(3):503-521. PMID: 28328149.
      View in: PubMed
    10. Zhang Z, Kukita C, Humayun MZ, Saier M. Environment-directed activation of the Escherichia coliflhDC operon by transposons. Microbiology. 2017 Apr; 163(4):554-569. PMID: 28100305.
      View in: PubMed
    11. Do J, Zafar H, Saier M. Comparative genomics of transport proteins in probiotic and pathogenic Escherichia coli and Salmonella enterica strains. Microb Pathog. 2017 Jun; 107:106-115. PMID: 28344124.
      View in: PubMed
    12. Saier M, Kukita C, Zhang Z. Transposon-mediated directed mutation in bacteria and eukaryotes. Front Biosci (Landmark Ed). 2017 03 01; 22:1458-1468. PMID: 28199212.
      View in: PubMed
    13. Vastermark A, Driker A, Weng J, Li X, Wang J, Saier M. Difference distance map data of alternative crystal forms of UlaA. Data Brief. 2017 Feb; 10:198-201. PMID: 27995154.
      View in: PubMed
    14. Chou A, Lee A, Hendargo KJ, Reddy VS, Shlykov MA, Kuppusamykrishnan H, Medrano-Soto A, Saier M. Characterization of the Tetraspan Junctional Complex (4JC) superfamily. Biochim Biophys Acta. 2017 Mar; 1859(3):402-414. PMID: 27916633.
      View in: PubMed
    15. Zhang Z, Saier M. Transposon-mediated activation of the Escherichia coli glpFK operon is inhibited by specific DNA-binding proteins: Implications for stress-induced transposition events. Mutat Res. 2016 Nov - Dec; 793-794:22-31. PMID: 27810619.
      View in: PubMed
    16. Vastermark A, Driker A, Weng J, Li X, Wang J, Saier M. The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism. J Struct Biol. 2016 12; 196(3):496-502. PMID: 27720943.
      View in: PubMed
    17. Kuppusamykrishnan H, Chau LM, Moreno-Hagelsieb G, Saier M. Analysis of 58 Families of Holins Using a Novel Program, PhyST. J Mol Microbiol Biotechnol. 2016; 26(6):381-388. PMID: 27553295.
      View in: PubMed
    18. Buyuktimkin B, Saier M. Comparative analyses of transport proteins encoded within the genomes of Leptospira species. Microb Pathog. 2016 Sep; 98:118-31. PMID: 27296707.
      View in: PubMed
    19. Vastermark A, Saier M. Time to Stop Holding the Elevator: A New Piece of the Transport Protein Mechanism Puzzle. Structure. 2016 06 07; 24(6):845-6. PMID: 27276425.
      View in: PubMed
    20. Saier M. Transport protein evolution deduced from analysis of sequence, topology and structure. Curr Opin Struct Biol. 2016 06; 38:9-17. PMID: 27270239.
      View in: PubMed
    21. Reddy BL, Saier M. Properties and Phylogeny of 76 Families of Bacterial and Eukaryotic Organellar Outer Membrane Pore-Forming Proteins. PLoS One. 2016; 11(4):e0152733. PMID: 27064789; PMCID: PMC4827864.
    22. Saier M, Reddy VS, Tsu BV, Ahmed MS, Li C, Moreno-Hagelsieb G. The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 04; 44(D1):D372-9. PMID: 26546518; PMCID: PMC4702804.
    23. Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier M, Wu W, Nigam SK. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One. 2015; 10(11):e0140569. PMID: 26536134.
      View in: PubMed
    24. Tsu BV, Saier M. The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis. PLoS One. 2015; 10(10):e0137184. PMID: 26474485; PMCID: PMC4608589.
    25. Buyuktimkin B, Saier M. Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species. Microb Pathog. 2015 Nov; 88:52-64. PMID: 26247102; PMCID: PMC4601928 [Available on 11/01/16].
    26. Babbitt PC, Bagos PG, Bairoch A, Bateman A, Chatonnet A, Chen MJ, Craik DJ, Finn RD, Gloriam D, Haft DH, Henrissat B, Holliday GL, Isberg V, Kaas Q, Landsman D, Lenfant N, Manning G, Nagano N, Srinivasan N, O'Donovan C, Pruitt KD, Sowdhamini R, Rawlings ND, Saier M, Sharman JL, Spedding M, Tsirigos KD, Vastermark A, Vriend G. Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database (Oxford). 2015; 2015:bav063. PMID: 26284514; PMCID: PMC4499208.
    27. Saier M. The Bacterial Phosphotransferase System: New Frontiers 50 Years after Its Discovery. J Mol Microbiol Biotechnol. 2015; 25(2-3):73-8. PMID: 26159069; PMCID: PMC4512285.
    28. Saier M, Zhang Z. Control of Transposon-Mediated Directed Mutation by the Escherichia coli Phosphoenolpyruvate:Sugar Phosphotransferase System. J Mol Microbiol Biotechnol. 2015; 25(2-3):226-33. PMID: 26159081; PMCID: PMC4511099.
    29. Holliday GL, Bairoch A, Bagos PG, Chatonnet A, Craik DJ, Finn RD, Henrissat B, Landsman D, Manning G, Nagano N, O'Donovan C, Pruitt KD, Rawlings ND, Saier M, Sowdhamini R, Spedding M, Srinivasan N, Vriend G, Babbitt PC, Bateman A. Key challenges for the creation and maintenance of specialist protein resources. Proteins. 2015 Jun; 83(6):1005-13. PMID: 25820941.
      View in: PubMed
    30. Reddy BL, Saier M. Autism and our intestinal microbiota. J Mol Microbiol Biotechnol. 2015; 25(1):51-5. PMID: 25792275.
      View in: PubMed
    31. Västermark Å, Driker A, Li J, Saier M. Conserved movement of TMS11 between occluded conformations of LacY and XylE of the major facilitator superfamily suggests a similar hinge-like mechanism. Proteins. 2015 Apr; 83(4):735-45. PMID: 25586173; PMCID: PMC4368487.
    32. Chiang Z, Vastermark A, Punta M, Coggill PC, Mistry J, Finn RD, Saier M. The complexity, challenges and benefits of comparing two transporter classification systems in TCDB and Pfam. Brief Bioinform. 2015 Sep; 16(5):865-72. PMID: 25614388; PMCID: PMC4570203.
    33. Kumar U, Saier M. Comparative genomic analysis of integral membrane transport proteins in ciliates. J Eukaryot Microbiol. 2015 Mar-Apr; 62(2):167-87. PMID: 25099884.
      View in: PubMed
    34. Tang F, Reddy BL, Saier M. Psychobiotics and their involvement in mental health. J Mol Microbiol Biotechnol. 2014; 24(4):211-4. PMID: 25196442.
      View in: PubMed
    35. Saier M, Reddy BL. Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications. J Bacteriol. 2015 Jan 01; 197(1):7-17. PMID: 25157079; PMCID: PMC4288690.
    36. Saier M, Zhang Z. Transposon-mediated directed mutation controlled by DNA binding proteins in Escherichia coli. Front Microbiol. 2014; 5:390. PMID: 25136335; PMCID: PMC4117983.
    37. Vastermark A, Wollwage S, Houle ME, Rio R, Saier M. Expansion of the APC superfamily of secondary carriers. Proteins. 2014 Oct; 82(10):2797-811. PMID: 25043943; PMCID: PMC4177346.
    38. Reddy A, Cho J, Ling S, Reddy V, Shlykov M, Saier M. Reliability of nine programs of topological predictions and their application to integral membrane channel and carrier proteins. J Mol Microbiol Biotechnol. 2014; 24(3):161-90. PMID: 24992992; PMCID: PMC4125430.
    39. Zhang Z, Aboulwafa M, Saier M. Regulation of crp gene expression by the catabolite repressor/activator, Cra, in Escherichia coli. J Mol Microbiol Biotechnol. 2014; 24(3):135-41. PMID: 24923415; PMCID: PMC4125524.
    40. Lee A, Vastermark A, Saier M. Establishing homology between mitochondrial calcium uniporters, prokaryotic magnesium channels and chlamydial IncA proteins. Microbiology. 2014 Aug; 160(Pt 8):1679-89. PMID: 24869855; PMCID: PMC4117221.
    41. Tang F, Saier M. Transport proteins promoting Escherichia coli pathogenesis. Microb Pathog. 2014 Jun-Jul; 71-72:41-55. PMID: 24747185; PMCID: PMC4106412.
    42. Västermark A, Lunt B, Saier M. Major facilitator superfamily porters, LacY, FucP and XylE of Escherichia coli appear to have evolved positionally dissimilar catalytic residues without rearrangement of 3-TMS repeat units. J Mol Microbiol Biotechnol. 2014; 24(2):82-90. PMID: 24603210; PMCID: PMC4048653.
    43. Västermark A, Saier M. Major Facilitator Superfamily (MFS) evolved without 3-transmembrane segment unit rearrangements. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):E1162-3. PMID: 24567407; PMCID: PMC3977298.
    44. Västermark A, Saier M. The involvement of transport proteins in transcriptional and metabolic regulation. Curr Opin Microbiol. 2014 Apr; 18:8-15. PMID: 24513656; PMCID: PMC3999241.
    45. Zhang K, Huentelman MJ, Rao F, Sun EI, Corneveaux JJ, Schork AJ, Wei Z, Waalen J, Miramontes-Gonzalez JP, Hightower CM, Maihofer AX, Mahata M, Pastinen T, Ehret GB. Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22; 63(15):1542-55. PMID: 24509276; PMCID: PMC3992204.
    46. Getsin I, Nalbandian GH, Yee DC, Vastermark A, Paparoditis PC, Reddy VS, Saier M. Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor. BMC Microbiol. 2013 Dec 05; 13:279. PMID: 24304716; PMCID: PMC3924187.
    47. Saier M, Reddy VS, Tamang DG, Västermark A. The transporter classification database. Nucleic Acids Res. 2014 Jan; 42(Database issue):D251-8. PMID: 24225317; PMCID: PMC3964967.
    48. Västermark Å, Saier M. Evolutionary relationship between 5+5 and 7+7 inverted repeat folds within the amino acid-polyamine-organocation superfamily. Proteins. 2014 Feb; 82(2):336-46. PMID: 24038584.
      View in: PubMed
    49. Yee DC, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier M. The transporter-opsin-G protein-coupled receptor (TOG) superfamily. FEBS J. 2013 Nov; 280(22):5780-800. PMID: 23981446; PMCID: PMC3832197.
    50. Sun EI, Leyn SA, Kazanov MD, Saier M, Novichkov PS, Rodionov DA. Comparative genomics of metabolic capacities of regulons controlled by cis-regulatory RNA motifs in bacteria. BMC Genomics. 2013 Sep 02; 14:597. PMID: 24060102; PMCID: PMC3766115.
    51. Aboulwafa M, Saier M. Lipid dependencies, biogenesis and cytoplasmic micellar forms of integral membrane sugar transport proteins of the bacterial phosphotransferase system. Microbiology. 2013 Nov; 159(Pt 11):2213-24. PMID: 23985145; PMCID: PMC3836488.
    52. Paparoditis P, Västermark A, Le AJ, Fuerst JA, Saier M. Bioinformatic analyses of integral membrane transport proteins encoded within the genome of the planctomycetes species, Rhodopirellula baltica. Biochim Biophys Acta. 2014 Jan; 1838(1 Pt B):193-215. PMID: 23969110; PMCID: PMC3905805.
    53. Saier M. Microcompartments and protein machines in prokaryotes. J Mol Microbiol Biotechnol. 2013; 23(4-5):243-69. PMID: 23920489; PMCID: PMC3832201.
    54. Reddy BL, Saier M. Topological and phylogenetic analyses of bacterial holin families and superfamilies. Biochim Biophys Acta. 2013 Nov; 1828(11):2654-71. PMID: 23856191; PMCID: PMC3788059.
    55. Zheng WH, Västermark Å, Shlykov MA, Reddy V, Sun EI, Saier M. Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters. BMC Microbiol. 2013 May 06; 13:98. PMID: 23647830; PMCID: PMC3654945.
    56. Saier M, Bogdanov MV. Membranous organelles in bacteria. J Mol Microbiol Biotechnol. 2013; 23(1-2):5-12. PMID: 23615191.
      View in: PubMed
    57. Bogdanov M, Aboulwafa M, Saier M. Subcellular localization and logistics of integral membrane protein biogenesis in Escherichia coli. J Mol Microbiol Biotechnol. 2013; 23(1-2):24-34. PMID: 23615193.
      View in: PubMed
    58. Lopez-de Los Santos Y, Chan H, Cantu VA, Rettner R, Sanchez F, Zhang Z, Saier M, Soberon X. Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity. J Biol Chem. 2012 Aug 24; 287(35):29931-9. PMID: 22767600; PMCID: PMC3436175.
    59. Trevors JT, Pollack GH, Saier M, Masson L. Transformative research: definitions, approaches and consequences. Theory Biosci. 2012 Jun; 131(2):117-23. PMID: 22628127; PMCID: PMC3990254.
    60. Wong FH, Chen JS, Reddy V, Day JL, Shlykov MA, Wakabayashi ST, Saier M. The amino acid-polyamine-organocation superfamily. J Mol Microbiol Biotechnol. 2012; 22(2):105-13. PMID: 22627175.
      View in: PubMed
    61. Reddy VS, Saier M. BioV Suite--a collection of programs for the study of transport protein evolution. FEBS J. 2012 Jun; 279(11):2036-46. PMID: 22568782; PMCID: PMC3978091.
    62. Reddy VS, Shlykov MA, Castillo R, Sun EI, Saier M. The major facilitator superfamily (MFS) revisited. FEBS J. 2012 Jun; 279(11):2022-35. PMID: 22458847; PMCID: PMC3425384.
    63. Chen JS, Reddy V, Chen JH, Shlykov MA, Zheng WH, Cho J, Yen MR, Saier M. Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. J Mol Microbiol Biotechnol. 2011; 21(3-4):83-96. PMID: 22286036; PMCID: PMC3290041.
    64. Zhang Z, Saier M. Transposon-mediated adaptive and directed mutations and their potential evolutionary benefits. J Mol Microbiol Biotechnol. 2011; 21(1-2):59-70. PMID: 22248543; PMCID: PMC3697268.
    65. Saier M. Did adaptive and directed mutation evolve to accelerate stress-induced evolutionary change? J Mol Microbiol Biotechnol. 2011; 21(1-2):5-7. PMID: 22248538.
      View in: PubMed
    66. Shlykov MA, Zheng WH, Chen JS, Saier M. Bioinformatic characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) family of transmembrane proteins. Biochim Biophys Acta. 2012 Mar; 1818(3):703-17. PMID: 22192777; PMCID: PMC3917603.
    67. Youm J, Saier M. Comparative analyses of transport proteins encoded within the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Biochim Biophys Acta. 2012 Mar; 1818(3):776-97. PMID: 22179038; PMCID: PMC3425379.
    68. Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol. 2011 Oct 17; 12(10):R100. PMID: 22004680; PMCID: PMC3341644.
    69. Aboulwafa M, Saier M. Biophysical studies of the membrane-embedded and cytoplasmic forms of the glucose-specific Enzyme II of the E. coli phosphotransferase system (PTS). PLoS One. 2011; 6(9):e24088. PMID: 21935376; PMCID: PMC3174158.
    70. Sehgal AK, Das S, Noto K, Saier M, Elkan C. Identifying relevant data for a biological database: handcrafted rules versus machine learning. IEEE/ACM Trans Comput Biol Bioinform. 2011 May-Jun; 8(3):851-7. PMID: 21393656; PMCID: PMC3980937.
    71. Silverio AL, Saier M. Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family. J Membr Biol. 2011 May; 241(2):77-101. PMID: 21519847; PMCID: PMC3980945.
    72. Gomolplitinant KM, Saier M. Evolution of the oligopeptide transporter family. J Membr Biol. 2011 Mar; 240(2):89-110. PMID: 21347612; PMCID: PMC3061005.
    73. Lam VH, Lee JH, Silverio A, Chan H, Gomolplitinant KM, Povolotsky TL, Orlova E, Sun EI, Welliver CH, Saier M. Pathways of transport protein evolution: recent advances. Biol Chem. 2011 Jan; 392(1-2):5-12. PMID: 21194372; PMCID: PMC4008129.
    74. Trevors JT, Saier M. Thermodynamic perspectives on genetic instructions, the laws of biology and diseased states. C R Biol. 2011 Jan; 334(1):1-5. PMID: 21262480; PMCID: PMC4092032.
    75. Tsai JC, Yen MR, Castillo R, Leyton DL, Henderson IR, Saier M. The bacterial intimins and invasins: a large and novel family of secreted proteins. PLoS One. 2010 Dec 22; 5(12):e14403. PMID: 21203509; PMCID: PMC3008723.
    76. Chan H, Babayan V, Blyumin E, Gandhi C, Hak K, Harake D, Kumar K, Lee P, Li TT, Liu HY, Lo TC, Meyer CJ, Stanford S, Zamora KS, Saier M. The p-type ATPase superfamily. J Mol Microbiol Biotechnol. 2010; 19(1-2):5-104. PMID: 20962537.
      View in: PubMed
    77. Castillo R, Saier M. Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. Int J Microbiol. 2010; 2010:187373. PMID: 20981284; PMCID: PMC2963123.
    78. Povolotsky TL, Orlova E, Tamang DG, Saier M. Defense against cannibalism: the SdpI family of bacterial immunity/signal transduction proteins. J Membr Biol. 2010 Jun; 235(3):145-62. PMID: 20563570; PMCID: PMC2910880.
    79. Rettner RE, Saier M. The autoinducer-2 exporter superfamily. J Mol Microbiol Biotechnol. 2010; 18(4):195-205. PMID: 20559013; PMCID: PMC3004238.
    80. Matias MG, Gomolplitinant KM, Tamang DG, Saier M. Animal Ca2+ release-activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators. BMC Res Notes. 2010 Jun 03; 3:158. PMID: 20525303; PMCID: PMC2894845.
    81. Choi SK, Saier M. Transcriptional Regulation of the rsbV Promoter Controlling Stress Responses to Ethanol, Carbon Limitation, and Phosphorous Limitation in Bacillus subtilis. Int J Microbiol. 2010; 2010:263410. PMID: 20454630; PMCID: PMC2862951.
    82. Pietack N, Becher D, Schmidl SR, Saier M, Hecker M, Commichau FM, Stülke J. In vitro phosphorylation of key metabolic enzymes from Bacillus subtilis: PrkC phosphorylates enzymes from different branches of basic metabolism. J Mol Microbiol Biotechnol. 2010; 18(3):129-40. PMID: 20389117.
      View in: PubMed
    83. Xiao AY, Wang J, Saier M. Bacterial Adaptor Membrane Fusion Proteins and the Structurally Dissimilar Outer Membrane Auxiliary Proteins Have Exchanged Central Domains in alpha-Proteobacteria. Int J Microbiol. 2010; 2010:589391. PMID: 20379386; PMCID: PMC2850547.
    84. Zhang Z, Yen MR, Saier M. Precise excision of IS5 from the intergenic region between the fucPIK and the fucAO operons and mutational control of fucPIK operon expression in Escherichia coli. J Bacteriol. 2010 Apr; 192(7):2013-9. PMID: 20097855; PMCID: PMC2838058.
    85. Yen MR, Chen JS, Marquez JL, Sun EI, Saier M. Multidrug resistance: phylogenetic characterization of superfamilies of secondary carriers that include drug exporters. Methods Mol Biol. 2010; 637:47-64. PMID: 20419429.
      View in: PubMed
    86. Trevors JT, Saier M. Education for Humanity. Water Air Soil Pollut. 2010 Feb; 206(1-4):1-2. PMID: 22247577.
      View in: PubMed
    87. Trevors JT, Saier M. Global Pollution: How Much Is Too Much? Water Air Soil Pollut. 2009 Nov; 204(1-4):1-3. PMID: 19898672.
      View in: PubMed
    88. Zhang Z, Saier M. A novel mechanism of transposon-mediated gene activation. PLoS Genet. 2009 Oct; 5(10):e1000689. PMID: 19834539; PMCID: PMC2753651.
    89. Wang B, Dukarevich M, Sun EI, Yen MR, Saier M. Membrane porters of ATP-binding cassette transport systems are polyphyletic. J Membr Biol. 2009 Sep; 231(1):1-10. PMID: 19806386.
      View in: PubMed
    90. Yen MR, Choi J, Saier M. Bioinformatic analyses of transmembrane transport: novel software for deducing protein phylogeny, topology, and evolution. J Mol Microbiol Biotechnol. 2009; 17(4):163-76. PMID: 19776645; PMCID: PMC2814153.
    91. Zhang Z, Saier M. A mechanism of transposon-mediated directed mutation. Mol Microbiol. 2009 Oct; 74(1):29-43. PMID: 19682247; PMCID: PMC2973706.
    92. Thever MD, Saier M. Bioinformatic characterization of p-type ATPases encoded within the fully sequenced genomes of 26 eukaryotes. J Membr Biol. 2009 Jun; 229(3):115-30. PMID: 19548020; PMCID: PMC2709905.
    93. Tamang DG, Rabus R, Barabote RD, Saier M. Comprehensive analyses of transport proteins encoded within the genome of "Aromatoleum aromaticum" strain EbN1. J Membr Biol. 2009 May; 229(2):53-90. PMID: 19506936.
      View in: PubMed
    94. Saier M, Yen MR, Noto K, Tamang DG, Elkan C. The Transporter Classification Database: recent advances. Nucleic Acids Res. 2009 Jan; 37(Database issue):D274-8. PMID: 19022853; PMCID: PMC2686586.
    95. Podar M, Anderson I, Makarova KS, Elkins JG, Ivanova N, Wall MA, Lykidis A, Mavromatis K, Sun H, Hudson ME, Chen W, Deciu C, Hutchison D, Eads JR, Anderson A, Fernandes F, Szeto E, Lapidus A, Kyrpides NC, Saier M, Richardson PM, Rachel R, Huber H, Eisen JA, Koonin EV, Keller M, Stetter KO. A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans. Genome Biol. 2008; 9(11):R158. PMID: 19000309; PMCID: PMC2614490.
    96. Amar P, Legent G, Thellier M, Ripoll C, Bernot G, Nystrom T, Saier M, Norris V. A stochastic automaton shows how enzyme assemblies may contribute to metabolic efficiency. BMC Syst Biol. 2008 Mar 25; 2:27. PMID: 18366733; PMCID: PMC2322945.
    97. Saier M. The bacterial chromosome. Crit Rev Biochem Mol Biol. 2008 Mar-Apr; 43(2):89-134. PMID: 18365861.
      View in: PubMed
    98. Aboulwafa M, Saier M. Characterization of the E. coli glucose permease fused to the maltose-binding protein. J Basic Microbiol. 2008 Feb; 48(1):3-9. PMID: 18247392.
      View in: PubMed
    99. Chen DE, Podell S, Sauer JD, Swanson MS, Saier M. The phagosomal nutrient transporter (Pht) family. Microbiology. 2008 Jan; 154(Pt 1):42-53. PMID: 18174124.
      View in: PubMed
    100. Saier M, Ma CH, Rodgers L, Tamang DG, Yen MR. Protein secretion and membrane insertion systems in bacteria and eukaryotic organelles. Adv Appl Microbiol. 2008; 65:141-97. PMID: 19026865.
      View in: PubMed
    101. Barabote RD, Rendulic S, Schuster SC, Saier M. Comprehensive analysis of transport proteins encoded within the genome of Bdellovibrio bacteriovorus. Genomics. 2007 Oct; 90(4):424-46. PMID: 17706914; PMCID: PMC3415317.
    102. Gutierrez-Ríos RM, Freyre-Gonzalez JA, Resendis O, Collado-Vides J, Saier M, Gosset G. Identification of regulatory network topological units coordinating the genome-wide transcriptional response to glucose in Escherichia coli. BMC Microbiol. 2007 Jun 08; 7:53. PMID: 17559662; PMCID: PMC1905917.
    103. Saier M. Protein secretion and membrane insertion systems in gram-negative bacteria. J Membr Biol. 2006; 214(2):75-90. PMID: 17546510.
      View in: PubMed
    104. Lee JH, Harvat EM, Stevens JM, Ferguson SJ, Saier M. Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins. Biochim Biophys Acta. 2007 Sep; 1768(9):2164-81. PMID: 17706591.
      View in: PubMed
    105. Zhang Z, Ma C, Pornillos O, Xiu X, Chang G, Saier M. Functional characterization of the heterooligomeric EbrAB multidrug efflux transporter of Bacillus subtilis. Biochemistry. 2007 May 01; 46(17):5218-25. PMID: 17417881.
      View in: PubMed
    106. Kuhlman T, Zhang Z, Saier M, Hwa T. Combinatorial transcriptional control of the lactose operon of Escherichia coli. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):6043-8. PMID: 17376875; PMCID: PMC1851613.
    107. Yen MR, Saier M. Gap junctional proteins of animals: the innexin/pannexin superfamily. Prog Biophys Mol Biol. 2007 May-Jun; 94(1-2):5-14. PMID: 17507077; PMCID: PMC2592087.
    108. Norris V, den Blaauwen T, Cabin-Flaman A, Doi RH, Harshey R, Janniere L, Jimenez-Sanchez A, Jin DJ, Levin PA, Mileykovskaya E, Minsky A, Saier M, Skarstad K. Functional taxonomy of bacterial hyperstructures. Microbiol Mol Biol Rev. 2007 Mar; 71(1):230-53. PMID: 17347523; PMCID: PMC1847379.
    109. Lorca GL, Barabote RD, Zlotopolski V, Tran C, Winnen B, Hvorup RN, Stonestrom AJ, Nguyen E, Huang LW, Kim DS, Saier M. Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses. Biochim Biophys Acta. 2007 Jun; 1768(6):1342-66. PMID: 17490609; PMCID: PMC2592090.
    110. Mansour NM, Sawhney M, Tamang DG, Vogl C, Saier M. The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS J. 2007 Feb; 274(3):612-29. PMID: 17288550.
      View in: PubMed
    111. Norris V, den Blaauwen T, Doi RH, Harshey RM, Janniere L, Jiménez-Sánchez A, Jin DJ, Levin PA, Mileykovskaya E, Minsky A, Misevic G, Ripoll C, Saier M, Skarstad K, Thellier M. Toward a hyperstructure taxonomy. Annu Rev Microbiol. 2007; 61:309-29. PMID: 17896876.
      View in: PubMed
    112. Saier M. Active transport in communication, protection and nutrition. J Mol Microbiol Biotechnol. 2007; 12(3-4):161-4. PMID: 17587865.
      View in: PubMed
    113. Aboulwafa M, Saier M. In vitro interconversion of the soluble and membrane- integrated forms of the Escherichia coli glucose enzyme II of the phosphoenolpyruvate-dependent sugar-transporting phosphotransferase system. J Mol Microbiol Biotechnol. 2007; 12(3-4):263-8. PMID: 17587874.
      View in: PubMed
    114. Kim DS, Chao Y, Saier M. Protein-translocating trimeric autotransporters of gram-negative bacteria. J Bacteriol. 2006 Aug; 188(16):5655-67. PMID: 16885434; PMCID: PMC1540064.
    115. Barabote RD, Tamang DG, Abeywardena SN, Fallah NS, Fu JY, Lio JK, Mirhosseini P, Pezeshk R, Podell S, Salampessy ML, Thever MD, Saier M. Extra domains in secondary transport carriers and channel proteins. Biochim Biophys Acta. 2006 Oct; 1758(10):1557-79. PMID: 16905115.
      View in: PubMed
    116. Au KM, Barabote RD, Hu KY, Saier M. Evolutionary appearance of H+-translocating pyrophosphatases. Microbiology. 2006 May; 152(Pt 5):1243-7. PMID: 16622041.
      View in: PubMed
    117. Saier M, Tran CV, Barabote RD. TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res. 2006 Jan 01; 34(Database issue):D181-6. PMID: 16381841; PMCID: PMC1334385.
    118. Soberón X, Saier M. Engineering transport protein function: theoretical and technical considerations using the sugar-transporting phosphotransferase system of Escherichia coli as a model system. J Mol Microbiol Biotechnol. 2006; 11(6):302-7. PMID: 17114894.
      View in: PubMed
    119. Saier M, Ren Q. The bioinformatic study of transmembrane molecular transport. J Mol Microbiol Biotechnol. 2006; 11(6):289-90. PMID: 17114892.
      View in: PubMed
    120. Nguyen TX, Yen MR, Barabote RD, Saier M. Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system. J Mol Microbiol Biotechnol. 2006; 11(6):345-60. PMID: 17114898.
      View in: PubMed
    121. Dumay QC, Debut AJ, Mansour NM, Saier M. The copper transporter (Ctr) family of Cu+ uptake systems. J Mol Microbiol Biotechnol. 2006; 11(1-2):10-9. PMID: 16825786.
      View in: PubMed
    122. Tamang DG, Saier M. The cecropin superfamily of toxic peptides. J Mol Microbiol Biotechnol. 2006; 11(1-2):94-103. PMID: 16825792.
      View in: PubMed
    123. Choi SK, Saier M. Mechanism of CcpA-mediated glucose repression of the resABCDE operon of Bacillus subtilis. J Mol Microbiol Biotechnol. 2006; 11(1-2):104-10. PMID: 16825793.
      View in: PubMed
    124. Debut AJ, Dumay QC, Barabote RD, Saier M. The iron/lead transporter superfamily of Fe/Pb2+ uptake systems. J Mol Microbiol Biotechnol. 2006; 11(1-2):1-9. PMID: 16825785.
      View in: PubMed
    125. Barabote RD, Saier M. Comparative genomic analyses of the bacterial phosphotransferase system. Microbiol Mol Biol Rev. 2005 Dec; 69(4):608-34. PMID: 16339738; PMCID: PMC1306802.
    126. Lorca GL, Chung YJ, Barabote RD, Weyler W, Schilling CH, Saier M. Catabolite repression and activation in Bacillus subtilis: dependency on CcpA, HPr, and HprK. J Bacteriol. 2005 Nov; 187(22):7826-39. PMID: 16267306; PMCID: PMC1280314.
    127. Choi SK, Saier M. Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis: potential connection between carbon and nitrogen metabolism. J Bacteriol. 2005 Oct; 187(19):6856-61. PMID: 16166551; PMCID: PMC1251575.
    128. Hagen AR, Barabote RD, Saier M. The bestrophin family of anion channels: identification of prokaryotic homologues. Mol Membr Biol. 2005 Jul-Aug; 22(4):291-302. PMID: 16154901.
      View in: PubMed
    129. Saier M, Hvorup RN, Barabote RD. Evolution of the bacterial phosphotransferase system: from carriers and enzymes to group translocators. Biochem Soc Trans. 2005 Feb; 33(Pt 1):220-4. PMID: 15667312.
      View in: PubMed
    130. Zhang Z, Gosset G, Barabote R, Gonzalez CS, Cuevas WA, Saier M. Functional interactions between the carbon and iron utilization regulators, Crp and Fur, in Escherichia coli. J Bacteriol. 2005 Feb; 187(3):980-90. PMID: 15659676; PMCID: PMC545712.
    131. Stonestrom A, Barabote RD, Gonzalez CF, Saier M. Bioinformatic analyses of bacterial HPr kinase/phosphorylase homologues. Res Microbiol. 2005 Apr; 156(3):443-51. PMID: 15808949.
      View in: PubMed
    132. Harvat EM, Zhang YM, Tran CV, Zhang Z, Frank MW, Rock CO, Saier M. Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily. J Biol Chem. 2005 Mar 25; 280(12):12028-34. PMID: 15661733.
      View in: PubMed
    133. Gonzalez CF, Stonestrom AJ, Lorca GL, Saier M. Biochemical characterization of phosphoryl transfer involving HPr of the phosphoenolpyruvate-dependent phosphotransferase system in Treponema denticola, an organism that lacks PTS permeases. Biochemistry. 2005 Jan 18; 44(2):598-608. PMID: 15641785.
      View in: PubMed
    134. von Rozycki T, Nies DH, Saier M. Genomic analyses of transport proteins in Ralstonia metallidurans. Comp Funct Genomics. 2005; 6(1-2):17-56. PMID: 18629293; PMCID: PMC2448597.
    135. Cabin-Flaman A, Ripoll C, Saier M, Norris V. Hypothesis: chemotaxis in Escherichia coli results from hyper-structure dynamics. J Mol Microbiol Biotechnol. 2005; 10(1):1-14. PMID: 16491021.
      View in: PubMed
    136. Choi SK, Saier M. Regulation of pho regulon gene expression by the carbon control protein A, CcpA, in Bacillus subtilis. J Mol Microbiol Biotechnol. 2005; 10(1):40-50. PMID: 16491025.
      View in: PubMed
    137. Saier M, Mansour NM. Probiotics and prebiotics in human health. J Mol Microbiol Biotechnol. 2005; 10(1):22-5. PMID: 16491023.
      View in: PubMed
    138. Deutscher J, Saier M. Ser/Thr/Tyr protein phosphorylation in bacteria - for long time neglected, now well established. J Mol Microbiol Biotechnol. 2005; 9(3-4):125-31. PMID: 16415586.
      View in: PubMed
    139. Aboulwafa M, Saier M. Characterization of soluble enzyme II complexes of the Escherichia coli phosphotransferase system. J Bacteriol. 2004 Dec; 186(24):8453-62. PMID: 15576795; PMCID: PMC532404.
    140. Khwaja M, Ma Q, Saier M. Topological analysis of integral membrane constituents of prokaryotic ABC efflux systems. Res Microbiol. 2005 Mar; 156(2):270-7. PMID: 15748994.
      View in: PubMed
    141. Kim SH, Chang AB, Saier M. Sequence similarity between multidrug resistance efflux pumps of the ABC and RND superfamilies. Microbiology. 2004 Aug; 150(Pt 8):2493-5. PMID: 15289545.
      View in: PubMed
    142. Busch W, Saier M. The IUBMB-endorsed transporter classification system. Mol Biotechnol. 2004 Jul; 27(3):253-62. PMID: 15247498.
      View in: PubMed
    143. Gosset G, Zhang Z, Nayyar S, Cuevas WA, Saier M. Transcriptome analysis of Crp-dependent catabolite control of gene expression in Escherichia coli. J Bacteriol. 2004 Jun; 186(11):3516-24. PMID: 15150239; PMCID: PMC415760.
    144. Chang AB, Lin R, Keith Studley W, Tran CV, Saier M. Phylogeny as a guide to structure and function of membrane transport proteins. Mol Membr Biol. 2004 May-Jun; 21(3):171-81. PMID: 15204625.
      View in: PubMed
    145. Bertram R, Schlicht M, Mahr K, Nothaft H, Saier M, Titgemeyer F. In silico and transcriptional analysis of carbohydrate uptake systems of Streptomyces coelicolor A3(2). J Bacteriol. 2004 Mar; 186(5):1362-73. PMID: 14973030; PMCID: PMC344420.
    146. Saier M. Evolution of bacterial type III protein secretion systems. Trends Microbiol. 2004 Mar; 12(3):113-5. PMID: 15001186.
      View in: PubMed
    147. von Rozycki T, Yen MR, Lende EE, Saier M. The YedZ family: possible heme binding proteins that can be fused to transporters and electron carriers. J Mol Microbiol Biotechnol. 2004; 8(3):129-40. PMID: 16088215.
      View in: PubMed
    148. Tran CV, Saier M. The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily. Microbiology. 2004 Jan; 150(Pt 1):1-3. PMID: 14702390.
      View in: PubMed
    149. von Rozycki T, Schultzel MA, Saier M. Sequence analyses of cyanobacterial bicarbonate transporters and their homologues. J Mol Microbiol Biotechnol. 2004; 7(3):102-8. PMID: 15263814.
      View in: PubMed
    150. Felce J, Saier M. Carbonic anhydrases fused to anion transporters of the SulP family: evidence for a novel type of bicarbonate transporter. J Mol Microbiol Biotechnol. 2004; 8(3):169-76. PMID: 16088218.
      View in: PubMed
    151. Chagneau C, Saier M. Biofilm-defective mutants of Bacillus subtilis. J Mol Microbiol Biotechnol. 2004; 8(3):177-88. PMID: 16088219.
      View in: PubMed
    152. Prakash S, Cooper G, Singhi S, Saier M. The ion transporter superfamily. Biochim Biophys Acta. 2003 Dec 03; 1618(1):79-92. PMID: 14643936.
      View in: PubMed
    153. Aboulwafa M, Hvorup R, Saier M. Dependency of sugar transport and phosphorylation by the phosphoenolpyruvate-dependent phosphotransferase system on membranous phosphatidylethanolamine in Escherichia coli: studies with a pssA mutant lacking phosphatidylserine synthase. Arch Microbiol. 2004 Jan; 181(1):26-34. PMID: 14634719.
      View in: PubMed
    154. Peabody CR, Chung YJ, Yen MR, Vidal-Ingigliardi D, Pugsley AP, Saier M. Type II protein secretion and its relationship to bacterial type IV pili and archaeal flagella. Microbiology. 2003 Nov; 149(Pt 11):3051-72. PMID: 14600218.
      View in: PubMed
    155. Winnen B, Hvorup RN, Saier M. The tripartite tricarboxylate transporter (TTT) family. Res Microbiol. 2003 Sep; 154(7):457-65. PMID: 14499931.
      View in: PubMed
    156. Zhai YF, Heijne W, Saier M. Molecular modeling of the bacterial outer membrane receptor energizer, ExbBD/TonB, based on homology with the flagellar motor, MotAB. Biochim Biophys Acta. 2003 Aug 07; 1614(2):201-10. PMID: 12896813.
      View in: PubMed
    157. Zhang Z, Feige JN, Chang AB, Anderson IJ, Brodianski VM, Vitreschak AG, Gelfand MS, Saier M. A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily. Arch Microbiol. 2003 Aug; 180(2):88-100. PMID: 12819857.
      View in: PubMed
    158. Saier M. Tracing pathways of transport protein evolution. Mol Microbiol. 2003 Jun; 48(5):1145-56. PMID: 12787345.
      View in: PubMed
    159. Lorca G, Winnen B, Saier M. Identification of the L-aspartate transporter in Bacillus subtilis. J Bacteriol. 2003 May; 185(10):3218-22. PMID: 12730183; PMCID: PMC154055.
    160. Aboulwafa M, Saier M. Soluble sugar permeases of the phosphotransferase system in Escherichia coli: evidence for two physically distinct forms of the proteins in vivo. Mol Microbiol. 2003 Apr; 48(1):131-41. PMID: 12657050.
      View in: PubMed
    161. Ma Q, Zhai Y, Schneider JC, Ramseier TM, Saier M. Protein secretion systems of Pseudomonas aeruginosa and P fluorescens. Biochim Biophys Acta. 2003 Apr 01; 1611(1-2):223-33. PMID: 12659964.
      View in: PubMed
    162. Zhang Z, Aboulwafa M, Smith MH, Saier M. The ascorbate transporter of Escherichia coli. J Bacteriol. 2003 Apr; 185(7):2243-50. PMID: 12644495; PMCID: PMC151508.
    163. Aboulwafa M, Chung YJ, Wai HH, Saier M. Studies on the Escherichia coli glucose-specific permease, PtsG, with a point mutation in its N-terminal amphipathic leader sequence. Microbiology. 2003 Mar; 149(Pt 3):763-71. PMID: 12634344.
      View in: PubMed
    164. Hvorup RN, Winnen B, Chang AB, Jiang Y, Zhou XF, Saier M. The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur J Biochem. 2003 Mar; 270(5):799-813. PMID: 12603313.
      View in: PubMed
    165. Pivetti CD, Yen MR, Miller S, Busch W, Tseng YH, Booth IR, Saier M. Two families of mechanosensitive channel proteins. Microbiol Mol Biol Rev. 2003 Mar; 67(1):66-85, table of contents. PMID: 12626684; PMCID: PMC150521.
    166. Cao TB, Saier M. The general protein secretory pathway: phylogenetic analyses leading to evolutionary conclusions. Biochim Biophys Acta. 2003 Jan 10; 1609(1):115-25. PMID: 12507766.
      View in: PubMed
    167. Zhou X, Hvorup RN, Saier M. An automated program to screen databases for members of protein families. J Mol Microbiol Biotechnol. 2003; 5(1):7-10. PMID: 12673056.
      View in: PubMed
    168. Busch W, Saier M. The IUBMB-endorsed transporter classification system. Methods Mol Biol. 2003; 227:21-36. PMID: 12824641.
      View in: PubMed
    169. Hvorup R, Chang AB, Saier M. Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family. J Mol Microbiol Biotechnol. 2003; 6(3-4):191-205. PMID: 15153772.
      View in: PubMed
    170. Minocha R, Studley K, Saier M. The urea transporter (UT) family: bioinformatic analyses leading to structural, functional, and evolutionary predictions. Receptors Channels. 2003; 9(6):345-52. PMID: 14698962.
      View in: PubMed
    171. Kimball RA, Martin L, Saier M. Reversing transmembrane electron flow: the DsbD and DsbB protein families. J Mol Microbiol Biotechnol. 2003; 5(3):133-49. PMID: 12766342.
      View in: PubMed
    172. Zhou X, Yang NM, Tran CV, Hvorup RN, Saier M. Web-based programs for the display and analysis of transmembrane alpha-helices in aligned protein sequences. J Mol Microbiol Biotechnol. 2003; 5(1):1-6. PMID: 12673055.
      View in: PubMed
    173. Aboulwafa M, Saier M. Dependency of sugar transport and phosphorylation by the phosphoenolpyruvate-dependent phosphotransferase system on membranous phosphatidyl glycerol in Escherichia coli: studies with a pgsA mutant lacking phosphatidyl glycerophosphate synthase. Res Microbiol. 2002 Dec; 153(10):667-77. PMID: 12558186.
      View in: PubMed
    174. Hvorup RN, Saier M. Sequence similarity between the channel-forming domains of voltage-gated ion channel proteins and the C-terminal domains of secondary carriers of the major facilitator superfamily. Microbiology. 2002 Dec; 148(Pt 12):3760-2. PMID: 12480878.
      View in: PubMed
    175. Greenberg DB, Stülke J, Saier M. Domain analysis of transcriptional regulators bearing PTS regulatory domains. Res Microbiol. 2002 Oct; 153(8):519-26. PMID: 12437213.
      View in: PubMed
    176. Zhai Y, Saier M. The beta-barrel finder (BBF) program, allowing identification of outer membrane beta-barrel proteins encoded within prokaryotic genomes. Protein Sci. 2002 Sep; 11(9):2196-207. PMID: 12192075; PMCID: PMC2373602.
    177. Hu KY, Saier M. Phylogeny of phosphoryl transfer proteins of the phosphoenolpyruvate-dependent sugar-transporting phosphotransferase system. Res Microbiol. 2002 Sep; 153(7):405-15. PMID: 12405346.
      View in: PubMed
    178. Klaenhammer T, Altermann E, Arigoni F, Bolotin A, Breidt F, Broadbent J, Cano R, Chaillou S, Deutscher J, Gasson M, van de Guchte M, Guzzo J, Hartke A, Hawkins T, Hols P, Hutkins R, Kleerebezem M, Kok J, Kuipers O, Lubbers M, Maguin E, McKay L, Mills D, Nauta A, Overbeek R, Pel H, Pridmore D, Saier M, van Sinderen D, Sorokin A, Steele J, O'Sullivan D, de Vos W, Weimer B, Zagorec M, Siezen R. Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek. 2002 Aug; 82(1-4):29-58. PMID: 12369195.
      View in: PubMed
    179. Zhai Y, Saier M. A simple sensitive program for detecting internal repeats in sets of multiply aligned homologous proteins. J Mol Microbiol Biotechnol. 2002 Jul; 4(4):375-7. PMID: 12125818.
      View in: PubMed
    180. Yen MR, Peabody CR, Partovi SM, Zhai Y, Tseng YH, Saier M. Protein-translocating outer membrane porins of Gram-negative bacteria. Biochim Biophys Acta. 2002 May 03; 1562(1-2):6-31. PMID: 11988218.
      View in: PubMed
    181. Chung YJ, Saier M. Overexpression of the Escherichia coli sugE gene confers resistance to a narrow range of quaternary ammonium compounds. J Bacteriol. 2002 May; 184(9):2543-5. PMID: 11948170; PMCID: PMC135002.
    182. Kimball RA, Saier M. Voltage-gated H+ channels associated with human phagocyte superoxide-generating NADPH oxidases: sequence comparisons, structural predictions, and phylogenetic analyses. Mol Membr Biol. 2002 Apr-Jun; 19(2):137-47. PMID: 12126231.
      View in: PubMed
    183. Kinch LN, Saier M, Grishin NV. Sec61beta--a component of the archaeal protein secretory system. Trends Biochem Sci. 2002 Apr; 27(4):170-1. PMID: 11943537.
      View in: PubMed
    184. Yen MR, Tseng YH, Nguyen EH, Wu LF, Saier M. Sequence and phylogenetic analyses of the twin-arginine targeting (Tat) protein export system. Arch Microbiol. 2002 Jun; 177(6):441-50. PMID: 12029389.
      View in: PubMed
    185. Zhai Y, Tchieu J, Saier M. A web-based Tree View (TV) program for the visualization of phylogenetic trees. J Mol Microbiol Biotechnol. 2002 Jan; 4(1):69-70. PMID: 11763971.
      View in: PubMed
    186. Saier M, Goldman SR, Maile RR, Moreno MS, Weyler W, Yang N, Paulsen IT. Transport capabilities encoded within the Bacillus subtilis genome. J Mol Microbiol Biotechnol. 2002 Jan; 4(1):37-67. PMID: 11763970.
      View in: PubMed
    187. Busch W, Saier M. The transporter classification (TC) system, 2002. Crit Rev Biochem Mol Biol. 2002; 37(5):287-337. PMID: 12449427.
      View in: PubMed
    188. Karp PD, Riley M, Saier M, Paulsen IT, Collado-Vides J, Paley SM, Pellegrini-Toole A, Bonavides C, Gama-Castro S. The EcoCyc Database. Nucleic Acids Res. 2002 Jan 01; 30(1):56-8. PMID: 11752253; PMCID: PMC99147.
    189. Quan JA, Schneider BL, Paulsen IT, Yamada M, Kredich NM, Saier M. Regulation of carbon utilization by sulfur availability in Escherichia coli and Salmonella typhimurium. Microbiology. 2002 Jan; 148(Pt 1):123-31. PMID: 11782505.
      View in: PubMed
    190. Yen MR, Tseng YH, Simic P, Sahm H, Eggeling L, Saier M. The ubiquitous ThrE family of putative transmembrane amino acid efflux transporters. Res Microbiol. 2002 Jan-Feb; 153(1):19-25. PMID: 11881894.
      View in: PubMed
    191. Amar P, Ballet P, Barlovatz-Meimon G, Benecke A, Bernot G, Bouligand Y, Bourguine P, Delaplace F, Delosme JM, Demarty M, Fishov I, Fourmentin-Guilbert J, Fralick J, Giavitto JL, Gleyse B, Godin C, Incitti R, Képès F, Lange C, Le Sceller L, Loutellier C, Michel O, Molina F, Monnier C, Natowicz R, Norris V, Orange N, Pollard H, Raine D, Ripoll C, Rouviere-Yaniv J, Saier M, Soler P, Tambourin P, Thellier M, Tracqui P, Ussery D, Vincent JC, Vannier JP, Wiggins P, Zemirline A. Hyperstructures, genome analysis and I-cells. Acta Biotheor. 2002; 50(4):357-73. PMID: 12675536.
      View in: PubMed
    192. Saier M. The bacterial phosphotransferase system: structure, function, regulation and evolution. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):325-7. PMID: 11361062.
      View in: PubMed
    193. Saier M, Paulsen IT. Phylogeny of multidrug transporters. Semin Cell Dev Biol. 2001 Jun; 12(3):205-13. PMID: 11428913.
      View in: PubMed
    194. Saier M, Paulsen IT. Whole genome analyses of transporters in spirochetes: Borrelia burgdorferi and Treponema pallidum. J Mol Microbiol Biotechnol. 2000 Oct; 2(4):393-9. PMID: 11075911.
      View in: PubMed
    195. Saier M. Vectorial metabolism and the evolution of transport systems. J Bacteriol. 2000 Sep; 182(18):5029-35. PMID: 10960084; PMCID: PMC94648.
    196. Saier M. Families of transmembrane transporters selective for amino acids and their derivatives. Microbiology. 2000 Aug; 146 ( Pt 8):1775-95. PMID: 10931885.
      View in: PubMed
    197. Saier M. A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol Mol Biol Rev. 2000 Jun; 64(2):354-411. PMID: 10839820; PMCID: PMC98997.
    198. Saier M. Families of transmembrane sugar transport proteins. Mol Microbiol. 2000 Feb; 35(4):699-710. PMID: 10692148.
      View in: PubMed
    199. Saier M, Paulsen IT. Paralogous genes encoding transport proteins in microbial genomes. Res Microbiol. 1999 Nov-Dec; 150(9-10):689-99. PMID: 10673007.
      View in: PubMed
    200. Saier M. Genome archeology leading to the characterization and classification of transport proteins. Curr Opin Microbiol. 1999 Oct; 2(5):555-61. PMID: 10508720.
      View in: PubMed
    201. Saier M, Eng BH, Fard S, Garg J, Haggerty DA, Hutchinson WJ, Jack DL, Lai EC, Liu HJ, Nusinew DP, Omar AM, Pao SS, Paulsen IT, Quan JA, Sliwinski M, Tseng TT, Wachi S, Young GB. Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochim Biophys Acta. 1999 Feb 25; 1422(1):1-56. PMID: 10082980.
      View in: PubMed
    202. Saier M. Eukaryotic transmembrane solute transport systems. Int Rev Cytol. 1999; 190:61-136. PMID: 10331239.
      View in: PubMed
    203. Saier M. Genome sequencing and informatics: new tools for biochemical discoveries. Plant Physiol. 1998 Aug; 117(4):1129-33. PMID: 9701568; PMCID: PMC1539184.
    204. Saier M. Multiple mechanisms controlling carbon metabolism in bacteria. Biotechnol Bioeng. 1998 Apr 20-May 5; 58(2-3):170-4. PMID: 10191387.
      View in: PubMed
    205. Saier M, Paulsen IT, Sliwinski MK, Pao SS, Skurray RA, Nikaido H. Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J. 1998 Mar; 12(3):265-74. PMID: 9506471.
      View in: PubMed
    206. Saier M. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv Microb Physiol. 1998; 40:81-136. PMID: 9889977.
      View in: PubMed
    207. Saier M, Chauvaux S, Cook GM, Deutscher J, Paulsen IT, Reizer J, Ye JJ. Catabolite repression and inducer control in Gram-positive bacteria. Microbiology. 1996 Feb; 142 ( Pt 2):217-30. PMID: 8932696.
      View in: PubMed
    208. Reizer J, Ramseier TM, Reizer A, Charbit A, Saier M. Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli. Microbiology. 1996 Feb; 142 ( Pt 2):231-50. PMID: 8932697.
      View in: PubMed