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Milton Saier

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0116
La Jolla CA 92093
Phone858-534-4084
Emailmsaier@ucsd.edu
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    Collapse Research 
    Collapse Research Activities and Funding
    Integrative functional mapping of the Escherichia coli membrane interactome
    NIH/NIGMS R01GM109895Sep 5, 2014 - Jul 31, 2018
    Role: Principal Investigator
    TransportPDB: Center for the X-ray Structure Determination of Human Transporters
    NIH/NIGMS U54GM094610Sep 30, 2010 - Jun 30, 2015
    Role: Co-Investigator
    The Transporter Classification Database (TCDB)
    NIH/NIGMS R01GM077402Apr 1, 2006 - Feb 28, 2019
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    ATP-Dependent Protein Kinases in Gram-Positive Bacteria
    NIH/NIGMS R01GM055434Dec 1, 1984 - Jun 30, 2006
    Role: Principal Investigator
    ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
    NIH/NIAID R01AI021702Dec 1, 1984 - Nov 30, 1996
    Role: Principal Investigator
    FUNCTION AND CONTROL OF A KIDNEY EPITHELIAL CELL LINE
    NIH/NIADDK R01AM021994Jul 1, 1979 - Mar 31, 1986
    Role: Principal Investigator
    Mechanism of Carbohydrate Transport in Bacteria
    NIH/NIGMS R01GM064368Sep 1, 1977 - Mar 31, 2006
    Role: Principal Investigator
    MECHANISM OF CARBOHYDRATE TRANSPORT IN BACTERIA
    NIH/NIAID R01AI014176Sep 1, 1977 - Mar 31, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rodionova IA, Goodacre N, Do J, Hosseinnia A, Babu M, Uetz P, Saier MH. The uridylyltransferase, GlnD, and tRNA modification GTPase, MnmE allosterically control Escherichia coli folylpoly-?-glutamate synthase, FolC. J Biol Chem. 2018 Aug 08. PMID: 30089654.
      View in: PubMed
    2. Medrano-Soto A, Moreno-Hagelsieb G, McLaughlin D, Ye ZS, Hendargo KJ, Saier MH. Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases. PLoS One. 2018; 13(3):e0192851. PMID: 29579047.
      View in: PubMed
    3. Rodionova IA, Goodacre N, Babu M, Emili A, Uetz P, Saier MH. The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli. J Bacteriol. 2018 Mar 01; 200(5). PMID: 29229699.
      View in: PubMed
    4. Heidari Tajabadi F, Medrano-Soto A, Ahmadzadeh M, Salehi Jouzani G, Saier MH. Comparative Analyses of Transport Proteins Encoded within the Genomes of Bdellovibrio bacteriovorus HD100 and Bdellovibrio exovorus JSS. J Mol Microbiol Biotechnol. 2017; 27(6):332-349. PMID: 29212086.
      View in: PubMed
    5. Babu M, Bundalovic-Torma C, Calmettes C, Phanse S, Zhang Q, Jiang Y, Minic Z, Kim S, Mehla J, Gagarinova A, Rodionova I, Kumar A, Guo H, Kagan O, Pogoutse O, Aoki H, Deineko V, Caufield JH, Holtzapple E, Zhang Z, Vastermark A, Pandya Y, Lai CC, El Bakkouri M, Hooda Y, Shah M, Burnside D, Hooshyar M, Vlasblom J, Rajagopala SV, Golshani A, Wuchty S, F Greenblatt J, Saier M, Uetz P, F Moraes T, Parkinson J, Emili A. Global landscape of cell envelope protein complexes in Escherichia coli. Nat Biotechnol. 2018 Jan; 36(1):103-112. PMID: 29176613.
      View in: PubMed
    6. Moreno-Hagelsieb G, Vitug B, Medrano-Soto A, Saier MH. The Membrane Attack Complex/Perforin Superfamily. J Mol Microbiol Biotechnol. 2017; 27(4):252-267. PMID: 29145176.
      View in: PubMed
    7. Humayun MZ, Zhang Z, Butcher AM, Moshayedi A, Saier MH. Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. PLoS One. 2017; 12(6):e0180156. PMID: 28666002.
      View in: PubMed
    8. Rodionova IA, Zhang Z, Mehla J, Goodacre N, Babu M, Emili A, Uetz P, Saier MH. The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli. J Biol Chem. 2017 08 25; 292(34):14250-14257. PMID: 28634232.
      View in: PubMed
    9. Saier MH, Trevors JT. Science, Innovation and the Future of Humanity. J Mol Microbiol Biotechnol. 2017; 27(2):128-132. PMID: 28448972.
      View in: PubMed
    10. Lee J, Ghosh S, Saier MH. Comparative genomic analyses of transport proteins encoded within the red algae Chondrus crispus, Galdieria sulphuraria, and Cyanidioschyzon merolae11. J Phycol. 2017 Jun; 53(3):503-521. PMID: 28328149.
      View in: PubMed
    11. Zhang Z, Kukita C, Humayun MZ, Saier MH. Environment-directed activation of the Escherichia coliflhDC operon by transposons. Microbiology. 2017 Apr; 163(4):554-569. PMID: 28100305.
      View in: PubMed
    12. Do J, Zafar H, Saier MH. Comparative genomics of transport proteins in probiotic and pathogenic Escherichia coli and Salmonella enterica strains. Microb Pathog. 2017 Jun; 107:106-115. PMID: 28344124.
      View in: PubMed
    13. Saier MH, Kukita C, Zhang Z. Transposon-mediated directed mutation in bacteria and eukaryotes. Front Biosci (Landmark Ed). 2017 03 01; 22:1458-1468. PMID: 28199212.
      View in: PubMed
    14. Vastermark A, Driker A, Weng J, Li X, Wang J, Saier MH. Difference distance map data of alternative crystal forms of UlaA. Data Brief. 2017 Feb; 10:198-201. PMID: 27995154.
      View in: PubMed
    15. Chou A, Lee A, Hendargo KJ, Reddy VS, Shlykov MA, Kuppusamykrishnan H, Medrano-Soto A, Saier MH. Characterization of the Tetraspan Junctional Complex (4JC) superfamily. Biochim Biophys Acta. 2017 Mar; 1859(3):402-414. PMID: 27916633.
      View in: PubMed
    16. Zhang Z, Saier MH. Transposon-mediated activation of the Escherichia coli glpFK operon is inhibited by specific DNA-binding proteins: Implications for stress-induced transposition events. Mutat Res. 2016 Nov - Dec; 793-794:22-31. PMID: 27810619.
      View in: PubMed
    17. Vastermark A, Driker A, Weng J, Li X, Wang J, Saier MH. The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism. J Struct Biol. 2016 12; 196(3):496-502. PMID: 27720943.
      View in: PubMed
    18. Kuppusamykrishnan H, Chau LM, Moreno-Hagelsieb G, Saier MH. Analysis of 58 Families of Holins Using a Novel Program, PhyST. J Mol Microbiol Biotechnol. 2016; 26(6):381-388. PMID: 27553295.
      View in: PubMed
    19. Buyuktimkin B, Saier MH. Comparative analyses of transport proteins encoded within the genomes of Leptospira species. Microb Pathog. 2016 Sep; 98:118-31. PMID: 27296707.
      View in: PubMed
    20. Vastermark A, Saier MH. Time to Stop Holding the Elevator: A New Piece of the Transport Protein Mechanism Puzzle. Structure. 2016 06 07; 24(6):845-6. PMID: 27276425.
      View in: PubMed
    21. Saier MH. Transport protein evolution deduced from analysis of sequence, topology and structure. Curr Opin Struct Biol. 2016 06; 38:9-17. PMID: 27270239.
      View in: PubMed
    22. Reddy BL, Saier MH. Properties and Phylogeny of 76 Families of Bacterial and Eukaryotic Organellar Outer Membrane Pore-Forming Proteins. PLoS One. 2016; 11(4):e0152733. PMID: 27064789; PMCID: PMC4827864.
    23. Saier MH, Reddy VS, Tsu BV, Ahmed MS, Li C, Moreno-Hagelsieb G. The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 04; 44(D1):D372-9. PMID: 26546518; PMCID: PMC4702804.
    24. Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH, Wu W, Nigam SK. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One. 2015; 10(11):e0140569. PMID: 26536134.
      View in: PubMed
    25. Tsu BV, Saier MH. The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis. PLoS One. 2015; 10(10):e0137184. PMID: 26474485; PMCID: PMC4608589.
    26. Buyuktimkin B, Saier MH. Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species. Microb Pathog. 2015 Nov; 88:52-64. PMID: 26247102; PMCID: PMC4601928 [Available on 11/01/16].
    27. Babbitt PC, Bagos PG, Bairoch A, Bateman A, Chatonnet A, Chen MJ, Craik DJ, Finn RD, Gloriam D, Haft DH, Henrissat B, Holliday GL, Isberg V, Kaas Q, Landsman D, Lenfant N, Manning G, Nagano N, Srinivasan N, O'Donovan C, Pruitt KD, Sowdhamini R, Rawlings ND, Saier MH, Sharman JL, Spedding M, Tsirigos KD, Vastermark A, Vriend G. Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database (Oxford). 2015; 2015:bav063. PMID: 26284514; PMCID: PMC4499208.
    28. Saier MH. The Bacterial Phosphotransferase System: New Frontiers 50 Years after Its Discovery. J Mol Microbiol Biotechnol. 2015; 25(2-3):73-8. PMID: 26159069; PMCID: PMC4512285.
    29. Saier MH, Zhang Z. Control of Transposon-Mediated Directed Mutation by the Escherichia coli Phosphoenolpyruvate:Sugar Phosphotransferase System. J Mol Microbiol Biotechnol. 2015; 25(2-3):226-33. PMID: 26159081; PMCID: PMC4511099.
    30. Holliday GL, Bairoch A, Bagos PG, Chatonnet A, Craik DJ, Finn RD, Henrissat B, Landsman D, Manning G, Nagano N, O'Donovan C, Pruitt KD, Rawlings ND, Saier M, Sowdhamini R, Spedding M, Srinivasan N, Vriend G, Babbitt PC, Bateman A. Key challenges for the creation and maintenance of specialist protein resources. Proteins. 2015 Jun; 83(6):1005-13. PMID: 25820941.
      View in: PubMed
    31. Reddy BL, Saier MH. Autism and our intestinal microbiota. J Mol Microbiol Biotechnol. 2015; 25(1):51-5. PMID: 25792275.
      View in: PubMed
    32. Västermark Å, Driker A, Li J, Saier MH. Conserved movement of TMS11 between occluded conformations of LacY and XylE of the major facilitator superfamily suggests a similar hinge-like mechanism. Proteins. 2015 Apr; 83(4):735-45. PMID: 25586173; PMCID: PMC4368487.
    33. Chiang Z, Vastermark A, Punta M, Coggill PC, Mistry J, Finn RD, Saier MH. The complexity, challenges and benefits of comparing two transporter classification systems in TCDB and Pfam. Brief Bioinform. 2015 Sep; 16(5):865-72. PMID: 25614388; PMCID: PMC4570203.
    34. Kumar U, Saier MH. Comparative genomic analysis of integral membrane transport proteins in ciliates. J Eukaryot Microbiol. 2015 Mar-Apr; 62(2):167-87. PMID: 25099884.
      View in: PubMed
    35. Tang F, Reddy BL, Saier MH. Psychobiotics and their involvement in mental health. J Mol Microbiol Biotechnol. 2014; 24(4):211-4. PMID: 25196442.
      View in: PubMed
    36. Saier MH, Reddy BL. Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications. J Bacteriol. 2015 Jan 01; 197(1):7-17. PMID: 25157079; PMCID: PMC4288690.
    37. Saier MH, Zhang Z. Transposon-mediated directed mutation controlled by DNA binding proteins in Escherichia coli. Front Microbiol. 2014; 5:390. PMID: 25136335; PMCID: PMC4117983.
    38. Vastermark A, Wollwage S, Houle ME, Rio R, Saier MH. Expansion of the APC superfamily of secondary carriers. Proteins. 2014 Oct; 82(10):2797-811. PMID: 25043943; PMCID: PMC4177346.
    39. Reddy A, Cho J, Ling S, Reddy V, Shlykov M, Saier MH. Reliability of nine programs of topological predictions and their application to integral membrane channel and carrier proteins. J Mol Microbiol Biotechnol. 2014; 24(3):161-90. PMID: 24992992; PMCID: PMC4125430.
    40. Zhang Z, Aboulwafa M, Saier MH. Regulation of crp gene expression by the catabolite repressor/activator, Cra, in Escherichia coli. J Mol Microbiol Biotechnol. 2014; 24(3):135-41. PMID: 24923415; PMCID: PMC4125524.
    41. Lee A, Vastermark A, Saier MH. Establishing homology between mitochondrial calcium uniporters, prokaryotic magnesium channels and chlamydial IncA proteins. Microbiology. 2014 Aug; 160(Pt 8):1679-89. PMID: 24869855; PMCID: PMC4117221.
    42. Tang F, Saier MH. Transport proteins promoting Escherichia coli pathogenesis. Microb Pathog. 2014 Jun-Jul; 71-72:41-55. PMID: 24747185; PMCID: PMC4106412.
    43. Västermark A, Lunt B, Saier M. Major facilitator superfamily porters, LacY, FucP and XylE of Escherichia coli appear to have evolved positionally dissimilar catalytic residues without rearrangement of 3-TMS repeat units. J Mol Microbiol Biotechnol. 2014; 24(2):82-90. PMID: 24603210; PMCID: PMC4048653.
    44. Västermark A, Saier MH. Major Facilitator Superfamily (MFS) evolved without 3-transmembrane segment unit rearrangements. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):E1162-3. PMID: 24567407; PMCID: PMC3977298.
    45. Västermark A, Saier MH. The involvement of transport proteins in transcriptional and metabolic regulation. Curr Opin Microbiol. 2014 Apr; 18:8-15. PMID: 24513656; PMCID: PMC3999241.
    46. Zhang K, Huentelman MJ, Rao F, Sun EI, Corneveaux JJ, Schork AJ, Wei Z, Waalen J, Miramontes-Gonzalez JP, Hightower CM, Maihofer AX, Mahata M, Pastinen T, Ehret GB. Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22; 63(15):1542-55. PMID: 24509276; PMCID: PMC3992204.
    47. Getsin I, Nalbandian GH, Yee DC, Vastermark A, Paparoditis PC, Reddy VS, Saier MH. Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor. BMC Microbiol. 2013 Dec 05; 13:279. PMID: 24304716; PMCID: PMC3924187.
    48. Saier MH, Reddy VS, Tamang DG, Västermark A. The transporter classification database. Nucleic Acids Res. 2014 Jan; 42(Database issue):D251-8. PMID: 24225317; PMCID: PMC3964967.
    49. Västermark Å, Saier MH. Evolutionary relationship between 5+5 and 7+7 inverted repeat folds within the amino acid-polyamine-organocation superfamily. Proteins. 2014 Feb; 82(2):336-46. PMID: 24038584.
      View in: PubMed
    50. Yee DC, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier MH. The transporter-opsin-G protein-coupled receptor (TOG) superfamily. FEBS J. 2013 Nov; 280(22):5780-800. PMID: 23981446; PMCID: PMC3832197.
    51. Sun EI, Leyn SA, Kazanov MD, Saier MH, Novichkov PS, Rodionov DA. Comparative genomics of metabolic capacities of regulons controlled by cis-regulatory RNA motifs in bacteria. BMC Genomics. 2013 Sep 02; 14:597. PMID: 24060102; PMCID: PMC3766115.
    52. Aboulwafa M, Saier MH. Lipid dependencies, biogenesis and cytoplasmic micellar forms of integral membrane sugar transport proteins of the bacterial phosphotransferase system. Microbiology. 2013 Nov; 159(Pt 11):2213-24. PMID: 23985145; PMCID: PMC3836488.
    53. Paparoditis P, Västermark A, Le AJ, Fuerst JA, Saier MH. Bioinformatic analyses of integral membrane transport proteins encoded within the genome of the planctomycetes species, Rhodopirellula baltica. Biochim Biophys Acta. 2014 Jan; 1838(1 Pt B):193-215. PMID: 23969110; PMCID: PMC3905805.
    54. Saier MH. Microcompartments and protein machines in prokaryotes. J Mol Microbiol Biotechnol. 2013; 23(4-5):243-69. PMID: 23920489; PMCID: PMC3832201.
    55. Reddy BL, Saier MH. Topological and phylogenetic analyses of bacterial holin families and superfamilies. Biochim Biophys Acta. 2013 Nov; 1828(11):2654-71. PMID: 23856191; PMCID: PMC3788059.
    56. Zheng WH, Västermark Å, Shlykov MA, Reddy V, Sun EI, Saier MH. Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters. BMC Microbiol. 2013 May 06; 13:98. PMID: 23647830; PMCID: PMC3654945.
    57. Saier MH, Bogdanov MV. Membranous organelles in bacteria. J Mol Microbiol Biotechnol. 2013; 23(1-2):5-12. PMID: 23615191.
      View in: PubMed
    58. Bogdanov M, Aboulwafa M, Saier MH. Subcellular localization and logistics of integral membrane protein biogenesis in Escherichia coli. J Mol Microbiol Biotechnol. 2013; 23(1-2):24-34. PMID: 23615193.
      View in: PubMed
    59. Lopez-de Los Santos Y, Chan H, Cantu VA, Rettner R, Sanchez F, Zhang Z, Saier MH, Soberon X. Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity. J Biol Chem. 2012 Aug 24; 287(35):29931-9. PMID: 22767600; PMCID: PMC3436175.
    60. Trevors JT, Pollack GH, Saier MH, Masson L. Transformative research: definitions, approaches and consequences. Theory Biosci. 2012 Jun; 131(2):117-23. PMID: 22628127; PMCID: PMC3990254.
    61. Wong FH, Chen JS, Reddy V, Day JL, Shlykov MA, Wakabayashi ST, Saier MH. The amino acid-polyamine-organocation superfamily. J Mol Microbiol Biotechnol. 2012; 22(2):105-13. PMID: 22627175.
      View in: PubMed
    62. Reddy VS, Saier MH. BioV Suite--a collection of programs for the study of transport protein evolution. FEBS J. 2012 Jun; 279(11):2036-46. PMID: 22568782; PMCID: PMC3978091.
    63. Reddy VS, Shlykov MA, Castillo R, Sun EI, Saier MH. The major facilitator superfamily (MFS) revisited. FEBS J. 2012 Jun; 279(11):2022-35. PMID: 22458847; PMCID: PMC3425384.
    64. Chen JS, Reddy V, Chen JH, Shlykov MA, Zheng WH, Cho J, Yen MR, Saier MH. Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. J Mol Microbiol Biotechnol. 2011; 21(3-4):83-96. PMID: 22286036; PMCID: PMC3290041.
    65. Zhang Z, Saier MH. Transposon-mediated adaptive and directed mutations and their potential evolutionary benefits. J Mol Microbiol Biotechnol. 2011; 21(1-2):59-70. PMID: 22248543; PMCID: PMC3697268.
    66. Saier MH. Did adaptive and directed mutation evolve to accelerate stress-induced evolutionary change? J Mol Microbiol Biotechnol. 2011; 21(1-2):5-7. PMID: 22248538.
      View in: PubMed
    67. Shlykov MA, Zheng WH, Chen JS, Saier MH. Bioinformatic characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) family of transmembrane proteins. Biochim Biophys Acta. 2012 Mar; 1818(3):703-17. PMID: 22192777; PMCID: PMC3917603.
    68. Youm J, Saier MH. Comparative analyses of transport proteins encoded within the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Biochim Biophys Acta. 2012 Mar; 1818(3):776-97. PMID: 22179038; PMCID: PMC3425379.
    69. Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol. 2011 Oct 17; 12(10):R100. PMID: 22004680; PMCID: PMC3341644.
    70. Aboulwafa M, Saier MH. Biophysical studies of the membrane-embedded and cytoplasmic forms of the glucose-specific Enzyme II of the E. coli phosphotransferase system (PTS). PLoS One. 2011; 6(9):e24088. PMID: 21935376; PMCID: PMC3174158.
    71. Sehgal AK, Das S, Noto K, Saier MH, Elkan C. Identifying relevant data for a biological database: handcrafted rules versus machine learning. IEEE/ACM Trans Comput Biol Bioinform. 2011 May-Jun; 8(3):851-7. PMID: 21393656; PMCID: PMC3980937.
    72. Silverio AL, Saier MH. Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family. J Membr Biol. 2011 May; 241(2):77-101. PMID: 21519847; PMCID: PMC3980945.
    73. Gomolplitinant KM, Saier MH. Evolution of the oligopeptide transporter family. J Membr Biol. 2011 Mar; 240(2):89-110. PMID: 21347612; PMCID: PMC3061005.
    74. Lam VH, Lee JH, Silverio A, Chan H, Gomolplitinant KM, Povolotsky TL, Orlova E, Sun EI, Welliver CH, Saier MH. Pathways of transport protein evolution: recent advances. Biol Chem. 2011 Jan; 392(1-2):5-12. PMID: 21194372; PMCID: PMC4008129.
    75. Trevors JT, Saier MH. Thermodynamic perspectives on genetic instructions, the laws of biology and diseased states. C R Biol. 2011 Jan; 334(1):1-5. PMID: 21262480; PMCID: PMC4092032.
    76. Tsai JC, Yen MR, Castillo R, Leyton DL, Henderson IR, Saier MH. The bacterial intimins and invasins: a large and novel family of secreted proteins. PLoS One. 2010 Dec 22; 5(12):e14403. PMID: 21203509; PMCID: PMC3008723.
    77. Castillo R, Saier MH. Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. Int J Microbiol. 2010; 2010:187373. PMID: 20981284; PMCID: PMC2963123.
    78. Chan H, Babayan V, Blyumin E, Gandhi C, Hak K, Harake D, Kumar K, Lee P, Li TT, Liu HY, Lo TC, Meyer CJ, Stanford S, Zamora KS, Saier MH. The p-type ATPase superfamily. J Mol Microbiol Biotechnol. 2010; 19(1-2):5-104. PMID: 20962537.
      View in: PubMed
    79. Povolotsky TL, Orlova E, Tamang DG, Saier MH. Defense against cannibalism: the SdpI family of bacterial immunity/signal transduction proteins. J Membr Biol. 2010 Jun; 235(3):145-62. PMID: 20563570; PMCID: PMC2910880.
    80. Rettner RE, Saier MH. The autoinducer-2 exporter superfamily. J Mol Microbiol Biotechnol. 2010; 18(4):195-205. PMID: 20559013; PMCID: PMC3004238.
    81. Matias MG, Gomolplitinant KM, Tamang DG, Saier MH. Animal Ca2+ release-activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators. BMC Res Notes. 2010 Jun 03; 3:158. PMID: 20525303; PMCID: PMC2894845.
    82. Choi SK, Saier MH. Transcriptional Regulation of the rsbV Promoter Controlling Stress Responses to Ethanol, Carbon Limitation, and Phosphorous Limitation in Bacillus subtilis. Int J Microbiol. 2010; 2010:263410. PMID: 20454630; PMCID: PMC2862951.
    83. Pietack N, Becher D, Schmidl SR, Saier MH, Hecker M, Commichau FM, Stülke J. In vitro phosphorylation of key metabolic enzymes from Bacillus subtilis: PrkC phosphorylates enzymes from different branches of basic metabolism. J Mol Microbiol Biotechnol. 2010; 18(3):129-40. PMID: 20389117.
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    84. Xiao AY, Wang J, Saier MH. Bacterial Adaptor Membrane Fusion Proteins and the Structurally Dissimilar Outer Membrane Auxiliary Proteins Have Exchanged Central Domains in alpha-Proteobacteria. Int J Microbiol. 2010; 2010:589391. PMID: 20379386; PMCID: PMC2850547.
    85. Zhang Z, Yen MR, Saier MH. Precise excision of IS5 from the intergenic region between the fucPIK and the fucAO operons and mutational control of fucPIK operon expression in Escherichia coli. J Bacteriol. 2010 Apr; 192(7):2013-9. PMID: 20097855; PMCID: PMC2838058.
    86. Yen MR, Chen JS, Marquez JL, Sun EI, Saier MH. Multidrug resistance: phylogenetic characterization of superfamilies of secondary carriers that include drug exporters. Methods Mol Biol. 2010; 637:47-64. PMID: 20419429.
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    87. Trevors JT, Saier MH. Education for Humanity. Water Air Soil Pollut. 2010 Feb; 206(1-4):1-2. PMID: 22247577.
      View in: PubMed
    88. Trevors JT, Saier MH. Global Pollution: How Much Is Too Much? Water Air Soil Pollut. 2009 Nov; 204(1-4):1-3. PMID: 19898672.
      View in: PubMed
    89. Zhang Z, Saier MH. A novel mechanism of transposon-mediated gene activation. PLoS Genet. 2009 Oct; 5(10):e1000689. PMID: 19834539; PMCID: PMC2753651.
    90. Wang B, Dukarevich M, Sun EI, Yen MR, Saier MH. Membrane porters of ATP-binding cassette transport systems are polyphyletic. J Membr Biol. 2009 Sep; 231(1):1-10. PMID: 19806386.
      View in: PubMed
    91. Yen MR, Choi J, Saier MH. Bioinformatic analyses of transmembrane transport: novel software for deducing protein phylogeny, topology, and evolution. J Mol Microbiol Biotechnol. 2009; 17(4):163-76. PMID: 19776645; PMCID: PMC2814153.
    92. Zhang Z, Saier MH. A mechanism of transposon-mediated directed mutation. Mol Microbiol. 2009 Oct; 74(1):29-43. PMID: 19682247; PMCID: PMC2973706.
    93. Thever MD, Saier MH. Bioinformatic characterization of p-type ATPases encoded within the fully sequenced genomes of 26 eukaryotes. J Membr Biol. 2009 Jun; 229(3):115-30. PMID: 19548020; PMCID: PMC2709905.
    94. Tamang DG, Rabus R, Barabote RD, Saier MH. Comprehensive analyses of transport proteins encoded within the genome of "Aromatoleum aromaticum" strain EbN1. J Membr Biol. 2009 May; 229(2):53-90. PMID: 19506936.
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    95. Saier MH, Yen MR, Noto K, Tamang DG, Elkan C. The Transporter Classification Database: recent advances. Nucleic Acids Res. 2009 Jan; 37(Database issue):D274-8. PMID: 19022853; PMCID: PMC2686586.
    96. Podar M, Anderson I, Makarova KS, Elkins JG, Ivanova N, Wall MA, Lykidis A, Mavromatis K, Sun H, Hudson ME, Chen W, Deciu C, Hutchison D, Eads JR, Anderson A, Fernandes F, Szeto E, Lapidus A, Kyrpides NC, Saier MH, Richardson PM, Rachel R, Huber H, Eisen JA, Koonin EV, Keller M, Stetter KO. A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans. Genome Biol. 2008; 9(11):R158. PMID: 19000309; PMCID: PMC2614490.
    97. Amar P, Legent G, Thellier M, Ripoll C, Bernot G, Nystrom T, Saier MH, Norris V. A stochastic automaton shows how enzyme assemblies may contribute to metabolic efficiency. BMC Syst Biol. 2008 Mar 25; 2:27. PMID: 18366733; PMCID: PMC2322945.
    98. Saier MH. The bacterial chromosome. Crit Rev Biochem Mol Biol. 2008 Mar-Apr; 43(2):89-134. PMID: 18365861.
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    99. Aboulwafa M, Saier MH. Characterization of the E. coli glucose permease fused to the maltose-binding protein. J Basic Microbiol. 2008 Feb; 48(1):3-9. PMID: 18247392.
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    100. Saier MH, Ma CH, Rodgers L, Tamang DG, Yen MR. Protein secretion and membrane insertion systems in bacteria and eukaryotic organelles. Adv Appl Microbiol. 2008; 65:141-97. PMID: 19026865.
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    101. Chen DE, Podell S, Sauer JD, Swanson MS, Saier MH. The phagosomal nutrient transporter (Pht) family. Microbiology. 2008 Jan; 154(Pt 1):42-53. PMID: 18174124.
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    102. Barabote RD, Rendulic S, Schuster SC, Saier MH. Comprehensive analysis of transport proteins encoded within the genome of Bdellovibrio bacteriovorus. Genomics. 2007 Oct; 90(4):424-46. PMID: 17706914; PMCID: PMC3415317.
    103. Gutierrez-Ríos RM, Freyre-Gonzalez JA, Resendis O, Collado-Vides J, Saier M, Gosset G. Identification of regulatory network topological units coordinating the genome-wide transcriptional response to glucose in Escherichia coli. BMC Microbiol. 2007 Jun 08; 7:53. PMID: 17559662; PMCID: PMC1905917.
    104. Saier MH. Protein secretion and membrane insertion systems in gram-negative bacteria. J Membr Biol. 2006; 214(2):75-90. PMID: 17546510.
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    105. Lee JH, Harvat EM, Stevens JM, Ferguson SJ, Saier MH. Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins. Biochim Biophys Acta. 2007 Sep; 1768(9):2164-81. PMID: 17706591.
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    106. Zhang Z, Ma C, Pornillos O, Xiu X, Chang G, Saier MH. Functional characterization of the heterooligomeric EbrAB multidrug efflux transporter of Bacillus subtilis. Biochemistry. 2007 May 01; 46(17):5218-25. PMID: 17417881.
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    107. Kuhlman T, Zhang Z, Saier MH, Hwa T. Combinatorial transcriptional control of the lactose operon of Escherichia coli. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):6043-8. PMID: 17376875; PMCID: PMC1851613.
    108. Yen MR, Saier MH. Gap junctional proteins of animals: the innexin/pannexin superfamily. Prog Biophys Mol Biol. 2007 May-Jun; 94(1-2):5-14. PMID: 17507077; PMCID: PMC2592087.
    109. Norris V, den Blaauwen T, Cabin-Flaman A, Doi RH, Harshey R, Janniere L, Jimenez-Sanchez A, Jin DJ, Levin PA, Mileykovskaya E, Minsky A, Saier M, Skarstad K. Functional taxonomy of bacterial hyperstructures. Microbiol Mol Biol Rev. 2007 Mar; 71(1):230-53. PMID: 17347523; PMCID: PMC1847379.
    110. Lorca GL, Barabote RD, Zlotopolski V, Tran C, Winnen B, Hvorup RN, Stonestrom AJ, Nguyen E, Huang LW, Kim DS, Saier MH. Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses. Biochim Biophys Acta. 2007 Jun; 1768(6):1342-66. PMID: 17490609; PMCID: PMC2592090.
    111. Mansour NM, Sawhney M, Tamang DG, Vogl C, Saier MH. The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS J. 2007 Feb; 274(3):612-29. PMID: 17288550.
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    112. Aboulwafa M, Saier MH. In vitro interconversion of the soluble and membrane- integrated forms of the Escherichia coli glucose enzyme II of the phosphoenolpyruvate-dependent sugar-transporting phosphotransferase system. J Mol Microbiol Biotechnol. 2007; 12(3-4):263-8. PMID: 17587874.
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    113. Norris V, den Blaauwen T, Doi RH, Harshey RM, Janniere L, Jiménez-Sánchez A, Jin DJ, Levin PA, Mileykovskaya E, Minsky A, Misevic G, Ripoll C, Saier M, Skarstad K, Thellier M. Toward a hyperstructure taxonomy. Annu Rev Microbiol. 2007; 61:309-29. PMID: 17896876.
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    114. Saier MH. Active transport in communication, protection and nutrition. J Mol Microbiol Biotechnol. 2007; 12(3-4):161-4. PMID: 17587865.
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    115. Kim DS, Chao Y, Saier MH. Protein-translocating trimeric autotransporters of gram-negative bacteria. J Bacteriol. 2006 Aug; 188(16):5655-67. PMID: 16885434; PMCID: PMC1540064.
    116. Barabote RD, Tamang DG, Abeywardena SN, Fallah NS, Fu JY, Lio JK, Mirhosseini P, Pezeshk R, Podell S, Salampessy ML, Thever MD, Saier MH. Extra domains in secondary transport carriers and channel proteins. Biochim Biophys Acta. 2006 Oct; 1758(10):1557-79. PMID: 16905115.
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    117. Au KM, Barabote RD, Hu KY, Saier MH. Evolutionary appearance of H+-translocating pyrophosphatases. Microbiology. 2006 May; 152(Pt 5):1243-7. PMID: 16622041.
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    118. Saier MH, Tran CV, Barabote RD. TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res. 2006 Jan 01; 34(Database issue):D181-6. PMID: 16381841; PMCID: PMC1334385.
    119. Nguyen TX, Yen MR, Barabote RD, Saier MH. Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system. J Mol Microbiol Biotechnol. 2006; 11(6):345-60. PMID: 17114898.
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    120. Debut AJ, Dumay QC, Barabote RD, Saier MH. The iron/lead transporter superfamily of Fe/Pb2+ uptake systems. J Mol Microbiol Biotechnol. 2006; 11(1-2):1-9. PMID: 16825785.
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    121. Saier MH, Ren Q. The bioinformatic study of transmembrane molecular transport. J Mol Microbiol Biotechnol. 2006; 11(6):289-90. PMID: 17114892.
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    122. Soberón X, Saier MH. Engineering transport protein function: theoretical and technical considerations using the sugar-transporting phosphotransferase system of Escherichia coli as a model system. J Mol Microbiol Biotechnol. 2006; 11(6):302-7. PMID: 17114894.
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    123. Tamang DG, Saier MH. The cecropin superfamily of toxic peptides. J Mol Microbiol Biotechnol. 2006; 11(1-2):94-103. PMID: 16825792.
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    124. Choi SK, Saier MH. Mechanism of CcpA-mediated glucose repression of the resABCDE operon of Bacillus subtilis. J Mol Microbiol Biotechnol. 2006; 11(1-2):104-10. PMID: 16825793.
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    125. Dumay QC, Debut AJ, Mansour NM, Saier MH. The copper transporter (Ctr) family of Cu+ uptake systems. J Mol Microbiol Biotechnol. 2006; 11(1-2):10-9. PMID: 16825786.
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    126. Barabote RD, Saier MH. Comparative genomic analyses of the bacterial phosphotransferase system. Microbiol Mol Biol Rev. 2005 Dec; 69(4):608-34. PMID: 16339738; PMCID: PMC1306802.
    127. Lorca GL, Chung YJ, Barabote RD, Weyler W, Schilling CH, Saier MH. Catabolite repression and activation in Bacillus subtilis: dependency on CcpA, HPr, and HprK. J Bacteriol. 2005 Nov; 187(22):7826-39. PMID: 16267306; PMCID: PMC1280314.
    128. Choi SK, Saier MH. Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis: potential connection between carbon and nitrogen metabolism. J Bacteriol. 2005 Oct; 187(19):6856-61. PMID: 16166551; PMCID: PMC1251575.
    129. Hagen AR, Barabote RD, Saier MH. The bestrophin family of anion channels: identification of prokaryotic homologues. Mol Membr Biol. 2005 Jul-Aug; 22(4):291-302. PMID: 16154901.
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    130. Saier MH, Hvorup RN, Barabote RD. Evolution of the bacterial phosphotransferase system: from carriers and enzymes to group translocators. Biochem Soc Trans. 2005 Feb; 33(Pt 1):220-4. PMID: 15667312.
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    131. Zhang Z, Gosset G, Barabote R, Gonzalez CS, Cuevas WA, Saier MH. Functional interactions between the carbon and iron utilization regulators, Crp and Fur, in Escherichia coli. J Bacteriol. 2005 Feb; 187(3):980-90. PMID: 15659676; PMCID: PMC545712.
    132. Stonestrom A, Barabote RD, Gonzalez CF, Saier MH. Bioinformatic analyses of bacterial HPr kinase/phosphorylase homologues. Res Microbiol. 2005 Apr; 156(3):443-51. PMID: 15808949.
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    133. Harvat EM, Zhang YM, Tran CV, Zhang Z, Frank MW, Rock CO, Saier MH. Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily. J Biol Chem. 2005 Mar 25; 280(12):12028-34. PMID: 15661733.
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    134. Gonzalez CF, Stonestrom AJ, Lorca GL, Saier MH. Biochemical characterization of phosphoryl transfer involving HPr of the phosphoenolpyruvate-dependent phosphotransferase system in Treponema denticola, an organism that lacks PTS permeases. Biochemistry. 2005 Jan 18; 44(2):598-608. PMID: 15641785.
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    135. Saier MH, Mansour NM. Probiotics and prebiotics in human health. J Mol Microbiol Biotechnol. 2005; 10(1):22-5. PMID: 16491023.
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    136. Choi SK, Saier MH. Regulation of pho regulon gene expression by the carbon control protein A, CcpA, in Bacillus subtilis. J Mol Microbiol Biotechnol. 2005; 10(1):40-50. PMID: 16491025.
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    137. Deutscher J, Saier MH. Ser/Thr/Tyr protein phosphorylation in bacteria - for long time neglected, now well established. J Mol Microbiol Biotechnol. 2005; 9(3-4):125-31. PMID: 16415586.
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    138. von Rozycki T, Nies DH, Saier MH. Genomic analyses of transport proteins in Ralstonia metallidurans. Comp Funct Genomics. 2005; 6(1-2):17-56. PMID: 18629293; PMCID: PMC2448597.
    139. Cabin-Flaman A, Ripoll C, Saier MH, Norris V. Hypothesis: chemotaxis in Escherichia coli results from hyper-structure dynamics. J Mol Microbiol Biotechnol. 2005; 10(1):1-14. PMID: 16491021.
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    140. Aboulwafa M, Saier MH. Characterization of soluble enzyme II complexes of the Escherichia coli phosphotransferase system. J Bacteriol. 2004 Dec; 186(24):8453-62. PMID: 15576795; PMCID: PMC532404.
    141. Khwaja M, Ma Q, Saier MH. Topological analysis of integral membrane constituents of prokaryotic ABC efflux systems. Res Microbiol. 2005 Mar; 156(2):270-7. PMID: 15748994.
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    142. Kim SH, Chang AB, Saier MH. Sequence similarity between multidrug resistance efflux pumps of the ABC and RND superfamilies. Microbiology. 2004 Aug; 150(Pt 8):2493-5. PMID: 15289545.
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    143. Busch W, Saier MH. The IUBMB-endorsed transporter classification system. Mol Biotechnol. 2004 Jul; 27(3):253-62. PMID: 15247498.
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    144. Gosset G, Zhang Z, Nayyar S, Cuevas WA, Saier MH. Transcriptome analysis of Crp-dependent catabolite control of gene expression in Escherichia coli. J Bacteriol. 2004 Jun; 186(11):3516-24. PMID: 15150239; PMCID: PMC415760.
    145. Chang AB, Lin R, Keith Studley W, Tran CV, Saier MH. Phylogeny as a guide to structure and function of membrane transport proteins. Mol Membr Biol. 2004 May-Jun; 21(3):171-81. PMID: 15204625.
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    146. Bertram R, Schlicht M, Mahr K, Nothaft H, Saier MH, Titgemeyer F. In silico and transcriptional analysis of carbohydrate uptake systems of Streptomyces coelicolor A3(2). J Bacteriol. 2004 Mar; 186(5):1362-73. PMID: 14973030; PMCID: PMC344420.
    147. Saier MH. Evolution of bacterial type III protein secretion systems. Trends Microbiol. 2004 Mar; 12(3):113-5. PMID: 15001186.
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    148. von Rozycki T, Schultzel MA, Saier MH. Sequence analyses of cyanobacterial bicarbonate transporters and their homologues. J Mol Microbiol Biotechnol. 2004; 7(3):102-8. PMID: 15263814.
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    149. Tran CV, Saier MH. The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily. Microbiology. 2004 Jan; 150(Pt 1):1-3. PMID: 14702390.
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    150. Felce J, Saier MH. Carbonic anhydrases fused to anion transporters of the SulP family: evidence for a novel type of bicarbonate transporter. J Mol Microbiol Biotechnol. 2004; 8(3):169-76. PMID: 16088218.
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    151. von Rozycki T, Yen MR, Lende EE, Saier MH. The YedZ family: possible heme binding proteins that can be fused to transporters and electron carriers. J Mol Microbiol Biotechnol. 2004; 8(3):129-40. PMID: 16088215.
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    152. Chagneau C, Saier MH. Biofilm-defective mutants of Bacillus subtilis. J Mol Microbiol Biotechnol. 2004; 8(3):177-88. PMID: 16088219.
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    153. Prakash S, Cooper G, Singhi S, Saier MH. The ion transporter superfamily. Biochim Biophys Acta. 2003 Dec 03; 1618(1):79-92. PMID: 14643936.
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    154. Aboulwafa M, Hvorup R, Saier MH. Dependency of sugar transport and phosphorylation by the phosphoenolpyruvate-dependent phosphotransferase system on membranous phosphatidylethanolamine in Escherichia coli: studies with a pssA mutant lacking phosphatidylserine synthase. Arch Microbiol. 2004 Jan; 181(1):26-34. PMID: 14634719.
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    155. Peabody CR, Chung YJ, Yen MR, Vidal-Ingigliardi D, Pugsley AP, Saier MH. Type II protein secretion and its relationship to bacterial type IV pili and archaeal flagella. Microbiology. 2003 Nov; 149(Pt 11):3051-72. PMID: 14600218.
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    156. Winnen B, Hvorup RN, Saier MH. The tripartite tricarboxylate transporter (TTT) family. Res Microbiol. 2003 Sep; 154(7):457-65. PMID: 14499931.
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    157. Zhai YF, Heijne W, Saier MH. Molecular modeling of the bacterial outer membrane receptor energizer, ExbBD/TonB, based on homology with the flagellar motor, MotAB. Biochim Biophys Acta. 2003 Aug 07; 1614(2):201-10. PMID: 12896813.
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    158. Zhang Z, Feige JN, Chang AB, Anderson IJ, Brodianski VM, Vitreschak AG, Gelfand MS, Saier MH. A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily. Arch Microbiol. 2003 Aug; 180(2):88-100. PMID: 12819857.
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    159. Saier MH. Tracing pathways of transport protein evolution. Mol Microbiol. 2003 Jun; 48(5):1145-56. PMID: 12787345.
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    160. Lorca G, Winnen B, Saier MH. Identification of the L-aspartate transporter in Bacillus subtilis. J Bacteriol. 2003 May; 185(10):3218-22. PMID: 12730183; PMCID: PMC154055.
    161. Zhang Z, Aboulwafa M, Smith MH, Saier MH. The ascorbate transporter of Escherichia coli. J Bacteriol. 2003 Apr; 185(7):2243-50. PMID: 12644495; PMCID: PMC151508.
    162. Aboulwafa M, Saier M. Soluble sugar permeases of the phosphotransferase system in Escherichia coli: evidence for two physically distinct forms of the proteins in vivo. Mol Microbiol. 2003 Apr; 48(1):131-41. PMID: 12657050.
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    163. Ma Q, Zhai Y, Schneider JC, Ramseier TM, Saier MH. Protein secretion systems of Pseudomonas aeruginosa and P fluorescens. Biochim Biophys Acta. 2003 Apr 01; 1611(1-2):223-33. PMID: 12659964.
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    164. Hvorup RN, Winnen B, Chang AB, Jiang Y, Zhou XF, Saier MH. The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur J Biochem. 2003 Mar; 270(5):799-813. PMID: 12603313.
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    165. Aboulwafa M, Chung YJ, Wai HH, Saier MH. Studies on the Escherichia coli glucose-specific permease, PtsG, with a point mutation in its N-terminal amphipathic leader sequence. Microbiology. 2003 Mar; 149(Pt 3):763-71. PMID: 12634344.
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    166. Pivetti CD, Yen MR, Miller S, Busch W, Tseng YH, Booth IR, Saier MH. Two families of mechanosensitive channel proteins. Microbiol Mol Biol Rev. 2003 Mar; 67(1):66-85, table of contents. PMID: 12626684; PMCID: PMC150521.
    167. Cao TB, Saier MH. The general protein secretory pathway: phylogenetic analyses leading to evolutionary conclusions. Biochim Biophys Acta. 2003 Jan 10; 1609(1):115-25. PMID: 12507766.
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    168. Zhou X, Hvorup RN, Saier MH. An automated program to screen databases for members of protein families. J Mol Microbiol Biotechnol. 2003; 5(1):7-10. PMID: 12673056.
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    169. Zhou X, Yang NM, Tran CV, Hvorup RN, Saier MH. Web-based programs for the display and analysis of transmembrane alpha-helices in aligned protein sequences. J Mol Microbiol Biotechnol. 2003; 5(1):1-6. PMID: 12673055.
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    170. Kimball RA, Martin L, Saier MH. Reversing transmembrane electron flow: the DsbD and DsbB protein families. J Mol Microbiol Biotechnol. 2003; 5(3):133-49. PMID: 12766342.
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    171. Busch W, Saier MH. The IUBMB-endorsed transporter classification system. Methods Mol Biol. 2003; 227:21-36. PMID: 12824641.
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    172. Minocha R, Studley K, Saier MH. The urea transporter (UT) family: bioinformatic analyses leading to structural, functional, and evolutionary predictions. Receptors Channels. 2003; 9(6):345-52. PMID: 14698962.
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    173. Hvorup R, Chang AB, Saier MH. Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family. J Mol Microbiol Biotechnol. 2003; 6(3-4):191-205. PMID: 15153772.
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    174. Aboulwafa M, Saier MH. Dependency of sugar transport and phosphorylation by the phosphoenolpyruvate-dependent phosphotransferase system on membranous phosphatidyl glycerol in Escherichia coli: studies with a pgsA mutant lacking phosphatidyl glycerophosphate synthase. Res Microbiol. 2002 Dec; 153(10):667-77. PMID: 12558186.
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    175. Hvorup RN, Saier MH. Sequence similarity between the channel-forming domains of voltage-gated ion channel proteins and the C-terminal domains of secondary carriers of the major facilitator superfamily. Microbiology. 2002 Dec; 148(Pt 12):3760-2. PMID: 12480878.
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    176. Greenberg DB, Stülke J, Saier MH. Domain analysis of transcriptional regulators bearing PTS regulatory domains. Res Microbiol. 2002 Oct; 153(8):519-26. PMID: 12437213.
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    177. Zhai Y, Saier MH. The beta-barrel finder (BBF) program, allowing identification of outer membrane beta-barrel proteins encoded within prokaryotic genomes. Protein Sci. 2002 Sep; 11(9):2196-207. PMID: 12192075; PMCID: PMC2373602.
    178. Hu KY, Saier MH. Phylogeny of phosphoryl transfer proteins of the phosphoenolpyruvate-dependent sugar-transporting phosphotransferase system. Res Microbiol. 2002 Sep; 153(7):405-15. PMID: 12405346.
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    179. Klaenhammer T, Altermann E, Arigoni F, Bolotin A, Breidt F, Broadbent J, Cano R, Chaillou S, Deutscher J, Gasson M, van de Guchte M, Guzzo J, Hartke A, Hawkins T, Hols P, Hutkins R, Kleerebezem M, Kok J, Kuipers O, Lubbers M, Maguin E, McKay L, Mills D, Nauta A, Overbeek R, Pel H, Pridmore D, Saier M, van Sinderen D, Sorokin A, Steele J, O'Sullivan D, de Vos W, Weimer B, Zagorec M, Siezen R. Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek. 2002 Aug; 82(1-4):29-58. PMID: 12369195.
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    180. Zhai Y, Saier MH. A simple sensitive program for detecting internal repeats in sets of multiply aligned homologous proteins. J Mol Microbiol Biotechnol. 2002 Jul; 4(4):375-7. PMID: 12125818.
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    181. Yen MR, Peabody CR, Partovi SM, Zhai Y, Tseng YH, Saier MH. Protein-translocating outer membrane porins of Gram-negative bacteria. Biochim Biophys Acta. 2002 May 03; 1562(1-2):6-31. PMID: 11988218.
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    182. Chung YJ, Saier MH. Overexpression of the Escherichia coli sugE gene confers resistance to a narrow range of quaternary ammonium compounds. J Bacteriol. 2002 May; 184(9):2543-5. PMID: 11948170; PMCID: PMC135002.
    183. Kinch LN, Saier MH, Grishin NV. Sec61beta--a component of the archaeal protein secretory system. Trends Biochem Sci. 2002 Apr; 27(4):170-1. PMID: 11943537.
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    184. Kimball RA, Saier MH. Voltage-gated H+ channels associated with human phagocyte superoxide-generating NADPH oxidases: sequence comparisons, structural predictions, and phylogenetic analyses. Mol Membr Biol. 2002 Apr-Jun; 19(2):137-47. PMID: 12126231.
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    185. Yen MR, Tseng YH, Nguyen EH, Wu LF, Saier MH. Sequence and phylogenetic analyses of the twin-arginine targeting (Tat) protein export system. Arch Microbiol. 2002 Jun; 177(6):441-50. PMID: 12029389.
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    186. Karp PD, Riley M, Saier M, Paulsen IT, Collado-Vides J, Paley SM, Pellegrini-Toole A, Bonavides C, Gama-Castro S. The EcoCyc Database. Nucleic Acids Res. 2002 Jan 01; 30(1):56-8. PMID: 11752253; PMCID: PMC99147.
    187. Zhai Y, Tchieu J, Saier MH. A web-based Tree View (TV) program for the visualization of phylogenetic trees. J Mol Microbiol Biotechnol. 2002 Jan; 4(1):69-70. PMID: 11763971.
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    188. Yen MR, Tseng YH, Simic P, Sahm H, Eggeling L, Saier MH. The ubiquitous ThrE family of putative transmembrane amino acid efflux transporters. Res Microbiol. 2002 Jan-Feb; 153(1):19-25. PMID: 11881894.
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    189. Amar P, Ballet P, Barlovatz-Meimon G, Benecke A, Bernot G, Bouligand Y, Bourguine P, Delaplace F, Delosme JM, Demarty M, Fishov I, Fourmentin-Guilbert J, Fralick J, Giavitto JL, Gleyse B, Godin C, Incitti R, Képès F, Lange C, Le Sceller L, Loutellier C, Michel O, Molina F, Monnier C, Natowicz R, Norris V, Orange N, Pollard H, Raine D, Ripoll C, Rouviere-Yaniv J, Saier M, Soler P, Tambourin P, Thellier M, Tracqui P, Ussery D, Vincent JC, Vannier JP, Wiggins P, Zemirline A. Hyperstructures, genome analysis and I-cells. Acta Biotheor. 2002; 50(4):357-73. PMID: 12675536.
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    190. Saier MH, Goldman SR, Maile RR, Moreno MS, Weyler W, Yang N, Paulsen IT. Transport capabilities encoded within the Bacillus subtilis genome. J Mol Microbiol Biotechnol. 2002 Jan; 4(1):37-67. PMID: 11763970.
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    191. Quan JA, Schneider BL, Paulsen IT, Yamada M, Kredich NM, Saier MH. Regulation of carbon utilization by sulfur availability in Escherichia coli and Salmonella typhimurium. Microbiology. 2002 Jan; 148(Pt 1):123-31. PMID: 11782505.
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    192. Busch W, Saier MH. The transporter classification (TC) system, 2002. Crit Rev Biochem Mol Biol. 2002; 37(5):287-337. PMID: 12449427.
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    193. Saier MH. The bacterial phosphotransferase system: structure, function, regulation and evolution. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):325-7. PMID: 11361062.
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    194. Saier MH, Paulsen IT. Phylogeny of multidrug transporters. Semin Cell Dev Biol. 2001 Jun; 12(3):205-13. PMID: 11428913.
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    195. Saier MH, Paulsen IT. Whole genome analyses of transporters in spirochetes: Borrelia burgdorferi and Treponema pallidum. J Mol Microbiol Biotechnol. 2000 Oct; 2(4):393-9. PMID: 11075911.
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    196. Saier MH. Vectorial metabolism and the evolution of transport systems. J Bacteriol. 2000 Sep; 182(18):5029-35. PMID: 10960084; PMCID: PMC94648.
    197. Saier MH. Families of transmembrane transporters selective for amino acids and their derivatives. Microbiology. 2000 Aug; 146 ( Pt 8):1775-95. PMID: 10931885.
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