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    Milton Saier

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0116
    CA La Jolla 92093
    Phone858-534-4084
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Integrative functional mapping of the Escherichia coli membrane interactome
      NIH/NIGMS R01GM109895Sep 5, 2014 - Jul 31, 2018
      Role: Principal Investigator
      TransportPDB: Center for the X-ray Structure Determination of Human Transporters
      NIH/NIGMS U54GM094610Sep 30, 2010 - Jun 30, 2015
      Role: Co-Investigator
      The Transporter Classification Database (TCDB)
      NIH/NIGMS R01GM077402Apr 1, 2006 - Feb 28, 2019
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      ATP-Dependent Protein Kinases in Gram-Positive Bacteria
      NIH/NIGMS R01GM055434Dec 1, 1984 - Jun 30, 2006
      Role: Principal Investigator
      ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
      NIH/NIAID R01AI021702Dec 1, 1984 - Nov 30, 1996
      Role: Principal Investigator
      FUNCTION AND CONTROL OF A KIDNEY EPITHELIAL CELL LINE
      NIH/NIADDK R01AM021994Jul 1, 1979 - Mar 31, 1986
      Role: Principal Investigator
      Mechanism of Carbohydrate Transport in Bacteria
      NIH/NIGMS R01GM064368Sep 1, 1977 - Mar 31, 2006
      Role: Principal Investigator
      MECHANISM OF CARBOHYDRATE TRANSPORT IN BACTERIA
      NIH/NIAID R01AI014176Sep 1, 1977 - Mar 31, 2001
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Humayun MZ, Zhang Z, Butcher AM, Moshayedi A, Saier M. Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. PLoS One. 2017; 12(6):e0180156. PMID: 28666002.
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      2. Rodionova IA, Zhang Z, Mehla J, Goodacre N, Babu M, Emili A, Uetz P, Saier M. The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli. J Biol Chem. 2017 Aug 25; 292(34):14250-14257. PMID: 28634232.
        View in: PubMed
      3. Lee J, Ghosh S, Saier M. Comparative genomic analyses of transport proteins encoded within the red algae Chondrus crispus, Galdieria sulphuraria, and Cyanidioschyzon merolae11. J Phycol. 2017 Jun; 53(3):503-521. PMID: 28328149.
        View in: PubMed
      4. Do J, Zafar H, Saier M. Comparative genomics of transport proteins in probiotic and pathogenic Escherichia coli and Salmonella enterica strains. Microb Pathog. 2017 Mar 24; 107:106-115. PMID: 28344124.
        View in: PubMed
      5. Saier M, Kukita C, Zhang Z. Transposon-mediated directed mutation in bacteria and eukaryotes. Front Biosci (Landmark Ed). 2017 Mar 01; 22:1458-1468. PMID: 28199212.
        View in: PubMed
      6. Zhang Z, Kukita C, Humayun MZ, Saier M. Environment-directed Activation the Escherichia coli flhDC Operon by Transposons. Microbiology. 2017 Jan 17. PMID: 28100305.
        View in: PubMed
      7. Vastermark A, Driker A, Weng J, Li X, Wang J, Saier M. Difference distance map data of alternative crystal forms of UlaA. Data Brief. 2017 Feb; 10:198-201. PMID: 27995154.
        View in: PubMed
      8. Chou A, Lee A, Hendargo KJ, Reddy VS, Shlykov MA, Kuppusamykrishnan H, Medrano-Soto A, Saier M. Characterization of the Tetraspan Junctional Complex (4JC) superfamily. Biochim Biophys Acta. 2017 Mar; 1859(3):402-414. PMID: 27916633.
        View in: PubMed
      9. Zhang Z, Saier M. Transposon-mediated activation of the Escherichia coli glpFK operon is inhibited by specific DNA-binding proteins: Implications for stress-induced transposition events. Mutat Res. 2016 Nov - Dec; 793-794:22-31. PMID: 27810619.
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      10. Vastermark A, Driker A, Weng J, Li X, Wang J, Saier M. The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism. J Struct Biol. 2016 Dec; 196(3):496-502. PMID: 27720943.
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      11. Kuppusamykrishnan H, Chau LM, Moreno-Hagelsieb G, Saier M. Analysis of 58 Families of Holins Using a Novel Program, PhyST. J Mol Microbiol Biotechnol. 2016; 26(6):381-388. PMID: 27553295.
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      12. Buyuktimkin B, Saier M. Comparative analyses of transport proteins encoded within the genomes of Leptospira species. Microb Pathog. 2016 Sep; 98:118-31. PMID: 27296707.
        View in: PubMed
      13. Vastermark A, Saier M. Time to Stop Holding the Elevator: A New Piece of the Transport Protein Mechanism Puzzle. Structure. 2016 Jun 7; 24(6):845-6. PMID: 27276425.
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      14. Saier M. Transport protein evolution deduced from analysis of sequence, topology and structure. Curr Opin Struct Biol. 2016 Jun; 38:9-17. PMID: 27270239.
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      15. Reddy BL, Saier M. Properties and Phylogeny of 76 Families of Bacterial and Eukaryotic Organellar Outer Membrane Pore-Forming Proteins. PLoS One. 2016; 11(4):e0152733. PMID: 27064789.
        View in: PubMed
      16. Saier M, Reddy VS, Tsu BV, Ahmed MS, Li C, Moreno-Hagelsieb G. The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4; 44(D1):D372-9. PMID: 26546518.
        View in: PubMed
      17. Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier M, Wu W, Nigam SK. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One. 2015; 10(11):e0140569. PMID: 26536134.
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      18. Tsu BV, Saier M. The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis. PLoS One. 2015; 10(10):e0137184. PMID: 26474485.
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      19. Buyuktimkin B, Saier M. Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species. Microb Pathog. 2015 Nov; 88:52-64. PMID: 26247102.
        View in: PubMed
      20. Babbitt PC, Bagos PG, Bairoch A, Bateman A, Chatonnet A, Chen MJ, Craik DJ, Finn RD, Gloriam D, Haft DH, Henrissat B, Holliday GL, Isberg V, Kaas Q, Landsman D, Lenfant N, Manning G, Nagano N, Srinivasan N, O'Donovan C, Pruitt KD, Sowdhamini R, Rawlings ND, Saier M, Sharman JL, Spedding M, Tsirigos KD, Vastermark A, Vriend G. Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database (Oxford). 2015; 2015:bav063. PMID: 26284514.
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      21. Saier M. The Bacterial Phosphotransferase System: New Frontiers 50 Years after Its Discovery. J Mol Microbiol Biotechnol. 2015; 25(2-3):73-8. PMID: 26159069.
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      22. Saier M, Zhang Z. Control of Transposon-Mediated Directed Mutation by the Escherichia coli Phosphoenolpyruvate:Sugar Phosphotransferase System. J Mol Microbiol Biotechnol. 2015; 25(2-3):226-33. PMID: 26159081.
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      23. Holliday GL, Bairoch A, Bagos PG, Chatonnet A, Craik DJ, Finn RD, Henrissat B, Landsman D, Manning G, Nagano N, O'Donovan C, Pruitt KD, Rawlings ND, Saier M, Sowdhamini R, Spedding M, Srinivasan N, Vriend G, Babbitt PC, Bateman A. Key challenges for the creation and maintenance of specialist protein resources. Proteins. 2015 Jun; 83(6):1005-13. PMID: 25820941.
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      24. Reddy BL, Saier M. Autism and our intestinal microbiota. J Mol Microbiol Biotechnol. 2015; 25(1):51-5. PMID: 25792275.
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      25. Västermark Å, Driker A, Li J, Saier M. Conserved movement of TMS11 between occluded conformations of LacY and XylE of the major facilitator superfamily suggests a similar hinge-like mechanism. Proteins. 2015 Apr; 83(4):735-45. PMID: 25586173.
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      26. Chiang Z, Vastermark A, Punta M, Coggill PC, Mistry J, Finn RD, Saier M. The complexity, challenges and benefits of comparing two transporter classification systems in TCDB and Pfam. Brief Bioinform. 2015 Sep; 16(5):865-72. PMID: 25614388.
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      27. Kumar U, Saier M. Comparative genomic analysis of integral membrane transport proteins in ciliates. J Eukaryot Microbiol. 2015 Mar-Apr; 62(2):167-87. PMID: 25099884.
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      28. Tang F, Reddy BL, Saier M. Psychobiotics and their involvement in mental health. J Mol Microbiol Biotechnol. 2014; 24(4):211-4. PMID: 25196442.
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      29. Saier M, Reddy BL. Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications. J Bacteriol. 2015 Jan 1; 197(1):7-17. PMID: 25157079.
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      30. Saier M, Zhang Z. Transposon-mediated directed mutation controlled by DNA binding proteins in Escherichia coli. Front Microbiol. 2014; 5:390. PMID: 25136335.
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      31. Vastermark A, Wollwage S, Houle ME, Rio R, Saier M. Expansion of the APC superfamily of secondary carriers. Proteins. 2014 Oct; 82(10):2797-811. PMID: 25043943.
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      32. Reddy A, Cho J, Ling S, Reddy V, Shlykov M, Saier M. Reliability of nine programs of topological predictions and their application to integral membrane channel and carrier proteins. J Mol Microbiol Biotechnol. 2014; 24(3):161-90. PMID: 24992992.
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      33. Zhang Z, Aboulwafa M, Saier M. Regulation of crp Gene Expression by the Catabolite Repressor/Activator, Cra, in Escherichia coli. J Mol Microbiol Biotechnol. 2014; 24(3):135-41. PMID: 24923415.
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      34. Lee A, Vastermark A, Saier M. Establishing homology between mitochondrial calcium uniporters, prokaryotic magnesium channels and chlamydial IncA proteins. Microbiology. 2014 Aug; 160(Pt 8):1679-89. PMID: 24869855.
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      35. Tang F, Saier M. Transport proteins promoting Escherichia coli pathogenesis. Microb Pathog. 2014 Jun-Jul; 71-72:41-55. PMID: 24747185.
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      36. Västermark A, Lunt B, Saier M. Major Facilitator Superfamily Porters, LacY, FucP and XylE of Escherichia coli Appear to Have Evolved Positionally Dissimilar Catalytic Residues without Rearrangement of 3-TMS Repeat Units. J Mol Microbiol Biotechnol. 2014; 24(2):82-90. PMID: 24603210.
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      37. Västermark A, Saier M. Major Facilitator Superfamily (MFS) evolved without 3-transmembrane segment unit rearrangements. Proc Natl Acad Sci U S A. 2014 Apr 1; 111(13):E1162-3. PMID: 24567407.
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      38. Västermark A, Saier M. The involvement of transport proteins in transcriptional and metabolic regulation. Curr Opin Microbiol. 2014 Apr; 18:8-15. PMID: 24513656.
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      39. Zhang K, Huentelman MJ, Rao F, Sun EI, Corneveaux JJ, Schork AJ, Wei Z, Waalen J, Miramontes-Gonzalez JP, Hightower CM, Maihofer AX, Mahata M, Pastinen T, Ehret GB. Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22; 63(15):1542-55. PMID: 24509276.
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      40. Getsin I, Nalbandian GH, Yee DC, Vastermark A, Paparoditis PC, Reddy VS, Saier M. Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor. BMC Microbiol. 2013; 13:279. PMID: 24304716.
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      41. Saier M, Reddy VS, Tamang DG, Västermark A. The transporter classification database. Nucleic Acids Res. 2014 Jan 1; 42(1):D251-8. PMID: 24225317.
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      42. Västermark A, Saier M. Evolutionary relationship between 5+5 and 7+7 inverted repeat folds within the amino acid-polyamine-organocation superfamily. Proteins. 2014 Feb; 82(2):336-46. PMID: 24038584.
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      43. Yee DC, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier M. The transporter-opsin-G protein-coupled receptor (TOG) superfamily. FEBS J. 2013 Nov; 280(22):5780-800. PMID: 23981446.
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      44. Sun EI, Leyn SA, Kazanov MD, Saier M, Novichkov PS, Rodionov DA. Comparative genomics of metabolic capacities of regulons controlled by cis-regulatory RNA motifs in bacteria. BMC Genomics. 2013; 14:597. PMID: 24060102.
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      45. Aboulwafa M, Saier M. Lipid dependencies, biogenesis and cytoplasmic micellar forms of integral membrane sugar transport proteins of the bacterial phosphotransferase system. Microbiology. 2013 Nov; 159(Pt 11):2213-24. PMID: 23985145.
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      46. Paparoditis P, Västermark A, Le AJ, Fuerst JA, Saier M. Bioinformatic analyses of integral membrane transport proteins encoded within the genome of the planctomycetes species, Rhodopirellula baltica. Biochim Biophys Acta. 2014 Jan; 1838(1):193-215. PMID: 23969110.
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      47. Saier M. Microcompartments and protein machines in prokaryotes. J Mol Microbiol Biotechnol. 2013; 23(4-5):243-69. PMID: 23920489.
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      48. Reddy BL, Saier M. Topological and phylogenetic analyses of bacterial holin families and superfamilies. Biochim Biophys Acta. 2013 Nov; 1828(11):2654-71. PMID: 23856191.
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      49. Zheng WH, Västermark Å, Shlykov MA, Reddy V, Sun EI, Saier M. Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters. BMC Microbiol. 2013; 13:98. PMID: 23647830.
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      50. Saier M, Bogdanov MV. Membranous organelles in bacteria. J Mol Microbiol Biotechnol. 2013; 23(1-2):5-12. PMID: 23615191.
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      51. Bogdanov M, Aboulwafa M, Saier M. Subcellular localization and logistics of integral membrane protein biogenesis in Escherichia coli. J Mol Microbiol Biotechnol. 2013; 23(1-2):24-34. PMID: 23615193.
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      52. Lopez-de Los Santos Y, Chan H, Cantu VA, Rettner R, Sanchez F, Zhang Z, Saier M, Soberon X. Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity. J Biol Chem. 2012 Aug 24; 287(35):29931-9. PMID: 22767600.
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      53. Trevors JT, Pollack GH, Saier M, Masson L. Transformative research: definitions, approaches and consequences. Theory Biosci. 2012 Jun; 131(2):117-23. PMID: 22628127.
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      54. Wong FH, Chen JS, Reddy V, Day JL, Shlykov MA, Wakabayashi ST, Saier M. The amino acid-polyamine-organocation superfamily. J Mol Microbiol Biotechnol. 2012; 22(2):105-13. PMID: 22627175.
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      55. Reddy VS, Shlykov MA, Castillo R, Sun EI, Saier M. The major facilitator superfamily (MFS) revisited. FEBS J. 2012 Jun; 279(11):2022-35. PMID: 22458847.
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      56. Reddy VS, Saier M. BioV Suite--a collection of programs for the study of transport protein evolution. FEBS J. 2012 Jun; 279(11):2036-46. PMID: 22568782.
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      57. Chen JS, Reddy V, Chen JH, Shlykov MA, Zheng WH, Cho J, Yen MR, Saier M. Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. J Mol Microbiol Biotechnol. 2011; 21(3-4):83-96. PMID: 22286036.
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      58. Zhang Z, Saier M. Transposon-mediated adaptive and directed mutations and their potential evolutionary benefits. J Mol Microbiol Biotechnol. 2011; 21(1-2):59-70. PMID: 22248543.
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      59. Saier M. Did adaptive and directed mutation evolve to accelerate stress-induced evolutionary change? J Mol Microbiol Biotechnol. 2011; 21(1-2):5-7. PMID: 22248538.
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      60. Shlykov MA, Zheng WH, Chen JS, Saier M. Bioinformatic characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) family of transmembrane proteins. Biochim Biophys Acta. 2012 Mar; 1818(3):703-17. PMID: 22192777.
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      61. Youm J, Saier M. Comparative analyses of transport proteins encoded within the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Biochim Biophys Acta. 2012 Mar; 1818(3):776-97. PMID: 22179038.
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      62. Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol. 2011; 12(10):R100. PMID: 22004680.
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      63. Aboulwafa M, Saier M. Biophysical studies of the membrane-embedded and cytoplasmic forms of the glucose-specific Enzyme II of the E. coli phosphotransferase system (PTS). PLoS One. 2011; 6(9):e24088. PMID: 21935376.
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      64. Sehgal AK, Das S, Noto K, Saier M, Elkan C. Identifying relevant data for a biological database: handcrafted rules versus machine learning. IEEE/ACM Trans Comput Biol Bioinform. 2011 May-Jun; 8(3):851-7. PMID: 21393656.
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      65. Silverio AL, Saier M. Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family. J Membr Biol. 2011 May; 241(2):77-101. PMID: 21519847.
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      66. Gomolplitinant KM, Saier M. Evolution of the oligopeptide transporter family. J Membr Biol. 2011 Mar; 240(2):89-110. PMID: 21347612.
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      67. Trevors JT, Saier M. A Vaccine Against Ignorance? Water Air Soil Pollut. 2011 Sep; 220(1-4):1-3. PMID: 21949450.
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      68. Lam VH, Lee JH, Silverio A, Chan H, Gomolplitinant KM, Povolotsky TL, Orlova E, Sun EI, Welliver CH, Saier M. Pathways of transport protein evolution: recent advances. Biol Chem. 2011 Jan; 392(1-2):5-12. PMID: 21194372.
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      69. Trevors JT, Saier M. Thermodynamic perspectives on genetic instructions, the laws of biology and diseased states. C R Biol. 2011 Jan; 334(1):1-5. PMID: 21262480.
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      70. Tsai JC, Yen MR, Castillo R, Leyton DL, Henderson IR, Saier M. The bacterial intimins and invasins: a large and novel family of secreted proteins. PLoS One. 2010; 5(12):e14403. PMID: 21203509.
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      71. Castillo R, Saier M. Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. Int J Microbiol. 2010; 2010:187373. PMID: 20981284.
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      72. Chan H, Babayan V, Blyumin E, Gandhi C, Hak K, Harake D, Kumar K, Lee P, Li TT, Liu HY, Lo TC, Meyer CJ, Stanford S, Zamora KS, Saier M. The p-type ATPase superfamily. J Mol Microbiol Biotechnol. 2010; 19(1-2):5-104. PMID: 20962537.
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      73. Trevors JT, Saier M. The Legacy of Oil Spills. Water Air Soil Pollut. 2010 Sep; 211(1-4):1-3. PMID: 20835295.
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      74. Povolotsky TL, Orlova E, Tamang DG, Saier M. Defense against cannibalism: the SdpI family of bacterial immunity/signal transduction proteins. J Membr Biol. 2010 Jun; 235(3):145-62. PMID: 20563570.
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      75. Rettner RE, Saier M. The autoinducer-2 exporter superfamily. J Mol Microbiol Biotechnol. 2010; 18(4):195-205. PMID: 20559013.
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      76. Matias MG, Gomolplitinant KM, Tamang DG, Saier M. Animal Ca2+ release-activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators. BMC Res Notes. 2010; 3:158. PMID: 20525303.
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      77. Choi SK, Saier M. Transcriptional Regulation of the rsbV Promoter Controlling Stress Responses to Ethanol, Carbon Limitation, and Phosphorous Limitation in Bacillus subtilis. Int J Microbiol. 2010; 2010:263410. PMID: 20454630.
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      78. Pietack N, Becher D, Schmidl SR, Saier M, Hecker M, Commichau FM, Stülke J. In vitro phosphorylation of key metabolic enzymes from Bacillus subtilis: PrkC phosphorylates enzymes from different branches of basic metabolism. J Mol Microbiol Biotechnol. 2010; 18(3):129-40. PMID: 20389117.
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      79. Xiao AY, Wang J, Saier M. Bacterial Adaptor Membrane Fusion Proteins and the Structurally Dissimilar Outer Membrane Auxiliary Proteins Have Exchanged Central Domains in alpha-Proteobacteria. Int J Microbiol. 2010; 2010:589391. PMID: 20379386.
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      80. Zhang Z, Yen MR, Saier M. Precise excision of IS5 from the intergenic region between the fucPIK and the fucAO operons and mutational control of fucPIK operon expression in Escherichia coli. J Bacteriol. 2010 Apr; 192(7):2013-9. PMID: 20097855.
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      81. Yen MR, Chen JS, Marquez JL, Sun EI, Saier M. Multidrug resistance: phylogenetic characterization of superfamilies of secondary carriers that include drug exporters. Methods Mol Biol. 2010; 637:47-64. PMID: 20419429.
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      82. Trevors JT, Saier M. Mathematics: The Basis for Quantitative Knowledge. Water Air Soil Pollut. 2010 Jun; 209(1-4):1-2. PMID: 22247578.
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      83. Trevors JT, Saier M. Education for Humanity. Water Air Soil Pollut. 2010 Feb; 206(1-4):1-2. PMID: 22247577.
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      84. Trevors JT, Saier M. Global Pollution: How Much Is Too Much? Water Air Soil Pollut. 2009 Nov; 204(1-4):1-3. PMID: 19898672.
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      85. Zhang Z, Saier M. A novel mechanism of transposon-mediated gene activation. PLoS Genet. 2009 Oct; 5(10):e1000689. PMID: 19834539.
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      86. Wang B, Dukarevich M, Sun EI, Yen MR, Saier M. Membrane porters of ATP-binding cassette transport systems are polyphyletic. J Membr Biol. 2009 Sep; 231(1):1-10. PMID: 19806386.
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      87. Yen MR, Choi J, Saier M. Bioinformatic analyses of transmembrane transport: novel software for deducing protein phylogeny, topology, and evolution. J Mol Microbiol Biotechnol. 2009; 17(4):163-76. PMID: 19776645.
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      88. Saier M, Trevors JT. Survival of the Fattest. Water Air Soil Pollut. 2009 Aug 20; 205(Suppl 1):107-109. PMID: 20157349.
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      89. Zhang Z, Saier M. A mechanism of transposon-mediated directed mutation. Mol Microbiol. 2009 Oct; 74(1):29-43. PMID: 19682247.
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      90. Thever MD, Saier M. Bioinformatic characterization of p-type ATPases encoded within the fully sequenced genomes of 26 eukaryotes. J Membr Biol. 2009 Jun; 229(3):115-30. PMID: 19548020.
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      91. Tamang DG, Rabus R, Barabote RD, Saier M. Comprehensive analyses of transport proteins encoded within the genome of "Aromatoleum aromaticum" strain EbN1. J Membr Biol. 2009 May; 229(2):53-90. PMID: 19506936.
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      92. Saier M, Yen MR, Noto K, Tamang DG, Elkan C. The Transporter Classification Database: recent advances. Nucleic Acids Res. 2009 Jan; 37(Database issue):D274-8. PMID: 19022853.
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      93. Podar M, Anderson I, Makarova KS, Elkins JG, Ivanova N, Wall MA, Lykidis A, Mavromatis K, Sun H, Hudson ME, Chen W, Deciu C, Hutchison D, Eads JR, Anderson A, Fernandes F, Szeto E, Lapidus A, Kyrpides NC, Saier M, Richardson PM, Rachel R, Huber H, Eisen JA, Koonin EV, Keller M, Stetter KO. A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans. Genome Biol. 2008; 9(11):R158. PMID: 19000309.
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      94. Amar P, Legent G, Thellier M, Ripoll C, Bernot G, Nystrom T, Saier M, Norris V. A stochastic automaton shows how enzyme assemblies may contribute to metabolic efficiency. BMC Syst Biol. 2008; 2:27. PMID: 18366733.
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      95. Saier M. The bacterial chromosome. Crit Rev Biochem Mol Biol. 2008 Mar-Apr; 43(2):89-134. PMID: 18365861.
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      96. Aboulwafa M, Saier M. Characterization of the E. coli glucose permease fused to the maltose-binding protein. J Basic Microbiol. 2008 Feb; 48(1):3-9. PMID: 18247392.
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      97. Saier M, Ma CH, Rodgers L, Tamang DG, Yen MR. Protein secretion and membrane insertion systems in bacteria and eukaryotic organelles. Adv Appl Microbiol. 2008; 65:141-97. PMID: 19026865.
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      98. Chen DE, Podell S, Sauer JD, Swanson MS, Saier M. The phagosomal nutrient transporter (Pht) family. Microbiology. 2008 Jan; 154(Pt 1):42-53. PMID: 18174124.
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      99. Barabote RD, Rendulic S, Schuster SC, Saier M. Comprehensive analysis of transport proteins encoded within the genome of Bdellovibrio bacteriovorus. Genomics. 2007 Oct; 90(4):424-46. PMID: 17706914.
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      100. Gutierrez-Ríos RM, Freyre-Gonzalez JA, Resendis O, Collado-Vides J, Saier M, Gosset G. Identification of regulatory network topological units coordinating the genome-wide transcriptional response to glucose in Escherichia coli. BMC Microbiol. 2007; 7:53. PMID: 17559662.
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      101. Saier M. Protein secretion and membrane insertion systems in gram-negative bacteria. J Membr Biol. 2006; 214(2):75-90. PMID: 17546510.
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      102. Lee JH, Harvat EM, Stevens JM, Ferguson SJ, Saier M. Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins. Biochim Biophys Acta. 2007 Sep; 1768(9):2164-81. PMID: 17706591.
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      103. Zhang Z, Ma C, Pornillos O, Xiu X, Chang G, Saier M. Functional characterization of the heterooligomeric EbrAB multidrug efflux transporter of Bacillus subtilis. Biochemistry. 2007 May 1; 46(17):5218-25. PMID: 17417881.
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      104. Kuhlman T, Zhang Z, Saier M, Hwa T. Combinatorial transcriptional control of the lactose operon of Escherichia coli. Proc Natl Acad Sci U S A. 2007 Apr 3; 104(14):6043-8. PMID: 17376875.
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      105. Yen MR, Saier M. Gap junctional proteins of animals: the innexin/pannexin superfamily. Prog Biophys Mol Biol. 2007 May-Jun; 94(1-2):5-14. PMID: 17507077.
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      106. Norris V, den Blaauwen T, Cabin-Flaman A, Doi RH, Harshey R, Janniere L, Jimenez-Sanchez A, Jin DJ, Levin PA, Mileykovskaya E, Minsky A, Saier M, Skarstad K. Functional taxonomy of bacterial hyperstructures. Microbiol Mol Biol Rev. 2007 Mar; 71(1):230-53. PMID: 17347523.
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      107. Lorca GL, Barabote RD, Zlotopolski V, Tran C, Winnen B, Hvorup RN, Stonestrom AJ, Nguyen E, Huang LW, Kim DS, Saier M. Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses. Biochim Biophys Acta. 2007 Jun; 1768(6):1342-66. PMID: 17490609.
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      108. Mansour NM, Sawhney M, Tamang DG, Vogl C, Saier M. The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS J. 2007 Feb; 274(3):612-29. PMID: 17288550.
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      109. Norris V, den Blaauwen T, Doi RH, Harshey RM, Janniere L, Jiménez-Sánchez A, Jin DJ, Levin PA, Mileykovskaya E, Minsky A, Misevic G, Ripoll C, Saier M, Skarstad K, Thellier M. Toward a hyperstructure taxonomy. Annu Rev Microbiol. 2007; 61:309-29. PMID: 17896876.
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      110. Aboulwafa M, Saier M. In vitro interconversion of the soluble and membrane- integrated forms of the Escherichia coli glucose enzyme II of the phosphoenolpyruvate-dependent sugar-transporting phosphotransferase system. J Mol Microbiol Biotechnol. 2007; 12(3-4):263-8. PMID: 17587874.
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      111. Saier M. Active transport in communication, protection and nutrition. J Mol Microbiol Biotechnol. 2007; 12(3-4):161-4. PMID: 17587865.
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      112. Makarova K, Slesarev A, Wolf Y, Sorokin A, Mirkin B, Koonin E, Pavlov A, Pavlova N, Karamychev V, Polouchine N, Shakhova V, Grigoriev I, Lou Y, Rohksar D, Lucas S, Huang K, Goodstein DM, Hawkins T, Plengvidhya V, Welker D, Hughes J, Goh Y, Benson A, Baldwin K, Lee JH, Díaz-Muñiz I, Dosti B, Smeianov V, Wechter W, Barabote R, Lorca G, Altermann E, Barrangou R, Ganesan B, Xie Y, Rawsthorne H, Tamir D, Parker C, Breidt F, Broadbent J, Hutkins R, O'Sullivan D, Steele J, Unlu G, Saier M, Klaenhammer T, Richardson P, Kozyavkin S, Weimer B, Mills D. Comparative genomics of the lactic acid bacteria. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15611-6. PMID: 17030793.
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      113. Kim DS, Chao Y, Saier M. Protein-translocating trimeric autotransporters of gram-negative bacteria. J Bacteriol. 2006 Aug; 188(16):5655-67. PMID: 16885434.
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      114. Barabote RD, Tamang DG, Abeywardena SN, Fallah NS, Fu JY, Lio JK, Mirhosseini P, Pezeshk R, Podell S, Salampessy ML, Thever MD, Saier M. Extra domains in secondary transport carriers and channel proteins. Biochim Biophys Acta. 2006 Oct; 1758(10):1557-79. PMID: 16905115.
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      115. Au KM, Barabote RD, Hu KY, Saier M. Evolutionary appearance of H+-translocating pyrophosphatases. Microbiology. 2006 May; 152(Pt 5):1243-7. PMID: 16622041.
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      116. Soberón X, Saier M. Engineering transport protein function: theoretical and technical considerations using the sugar-transporting phosphotransferase system of Escherichia coli as a model system. J Mol Microbiol Biotechnol. 2006; 11(6):302-7. PMID: 17114894.
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      117. Choi SK, Saier M. Mechanism of CcpA-mediated glucose repression of the resABCDE operon of Bacillus subtilis. J Mol Microbiol Biotechnol. 2006; 11(1-2):104-10. PMID: 16825793.
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      118. Debut AJ, Dumay QC, Barabote RD, Saier M. The iron/lead transporter superfamily of Fe/Pb2+ uptake systems. J Mol Microbiol Biotechnol. 2006; 11(1-2):1-9. PMID: 16825785.
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      119. Saier M, Ren Q. The bioinformatic study of transmembrane molecular transport. J Mol Microbiol Biotechnol. 2006; 11(6):289-90. PMID: 17114892.
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      120. Saier M, Tran CV, Barabote RD. TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res. 2006 Jan 1; 34(Database issue):D181-6. PMID: 16381841.
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      121. Nguyen TX, Yen MR, Barabote RD, Saier M. Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system. J Mol Microbiol Biotechnol. 2006; 11(6):345-60. PMID: 17114898.
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      122. Tamang DG, Saier M. The cecropin superfamily of toxic peptides. J Mol Microbiol Biotechnol. 2006; 11(1-2):94-103. PMID: 16825792.
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      123. Dumay QC, Debut AJ, Mansour NM, Saier M. The copper transporter (Ctr) family of Cu+ uptake systems. J Mol Microbiol Biotechnol. 2006; 11(1-2):10-9. PMID: 16825786.
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      124. Barabote RD, Saier M. Comparative genomic analyses of the bacterial phosphotransferase system. Microbiol Mol Biol Rev. 2005 Dec; 69(4):608-34. PMID: 16339738.
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      125. Lorca GL, Chung YJ, Barabote RD, Weyler W, Schilling CH, Saier M. Catabolite repression and activation in Bacillus subtilis: dependency on CcpA, HPr, and HprK. J Bacteriol. 2005 Nov; 187(22):7826-39. PMID: 16267306.
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      126. Choi SK, Saier M. Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis: potential connection between carbon and nitrogen metabolism. J Bacteriol. 2005 Oct; 187(19):6856-61. PMID: 16166551.
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      127. Hagen AR, Barabote RD, Saier M. The bestrophin family of anion channels: identification of prokaryotic homologues. Mol Membr Biol. 2005 Jul-Aug; 22(4):291-302. PMID: 16154901.
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      128. Saier M, Hvorup RN, Barabote RD. Evolution of the bacterial phosphotransferase system: from carriers and enzymes to group translocators. Biochem Soc Trans. 2005 Feb; 33(Pt 1):220-4. PMID: 15667312.
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      129. Zhang Z, Gosset G, Barabote R, Gonzalez CS, Cuevas WA, Saier M. Functional interactions between the carbon and iron utilization regulators, Crp and Fur, in Escherichia coli. J Bacteriol. 2005 Feb; 187(3):980-90. PMID: 15659676.
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      130. Stonestrom A, Barabote RD, Gonzalez CF, Saier M. Bioinformatic analyses of bacterial HPr kinase/phosphorylase homologues. Res Microbiol. 2005 Apr; 156(3):443-51. PMID: 15808949.
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      131. Harvat EM, Zhang YM, Tran CV, Zhang Z, Frank MW, Rock CO, Saier M. Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily. J Biol Chem. 2005 Mar 25; 280(12):12028-34. PMID: 15661733.
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      132. Gonzalez CF, Stonestrom AJ, Lorca GL, Saier M. Biochemical characterization of phosphoryl transfer involving HPr of the phosphoenolpyruvate-dependent phosphotransferase system in Treponema denticola, an organism that lacks PTS permeases. Biochemistry. 2005 Jan 18; 44(2):598-608. PMID: 15641785.
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      133. Saier M. Beneficial bacteria and bioremediation. J Mol Microbiol Biotechnol. 2005; 9(2):63-4. PMID: 16319495.
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      134. Deutscher J, Saier M. Ser/Thr/Tyr protein phosphorylation in bacteria - for long time neglected, now well established. J Mol Microbiol Biotechnol. 2005; 9(3-4):125-31. PMID: 16415586.
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      135. von Rozycki T, Nies DH, Saier M. Genomic analyses of transport proteins in Ralstonia metallidurans. Comp Funct Genomics. 2005; 6(1-2):17-56. PMID: 18629293.
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      136. Cabin-Flaman A, Ripoll C, Saier M, Norris V. Hypothesis: chemotaxis in Escherichia coli results from hyper-structure dynamics. J Mol Microbiol Biotechnol. 2005; 10(1):1-14. PMID: 16491021.
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      137. Saier M, Mansour NM. Probiotics and prebiotics in human health. J Mol Microbiol Biotechnol. 2005; 10(1):22-5. PMID: 16491023.
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      138. Choi SK, Saier M. Regulation of pho regulon gene expression by the carbon control protein A, CcpA, in Bacillus subtilis. J Mol Microbiol Biotechnol. 2005; 10(1):40-50. PMID: 16491025.
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      139. Aboulwafa M, Saier M. Characterization of soluble enzyme II complexes of the Escherichia coli phosphotransferase system. J Bacteriol. 2004 Dec; 186(24):8453-62. PMID: 15576795.
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      140. Khwaja M, Ma Q, Saier M. Topological analysis of integral membrane constituents of prokaryotic ABC efflux systems. Res Microbiol. 2005 Mar; 156(2):270-7. PMID: 15748994.
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      141. Kim SH, Chang AB, Saier M. Sequence similarity between multidrug resistance efflux pumps of the ABC and RND superfamilies. Microbiology. 2004 Aug; 150(Pt 8):2493-5. PMID: 15289545.
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      142. Busch W, Saier M. The IUBMB-endorsed transporter classification system. Mol Biotechnol. 2004 Jul; 27(3):253-62. PMID: 15247498.
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      143. Gosset G, Zhang Z, Nayyar S, Cuevas WA, Saier M. Transcriptome analysis of Crp-dependent catabolite control of gene expression in Escherichia coli. J Bacteriol. 2004 Jun; 186(11):3516-24. PMID: 15150239.
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      144. Chang AB, Lin R, Keith Studley W, Tran CV, Saier M. Phylogeny as a guide to structure and function of membrane transport proteins. Mol Membr Biol. 2004 May-Jun; 21(3):171-81. PMID: 15204625.
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      145. Bertram R, Schlicht M, Mahr K, Nothaft H, Saier M, Titgemeyer F. In silico and transcriptional analysis of carbohydrate uptake systems of Streptomyces coelicolor A3(2). J Bacteriol. 2004 Mar; 186(5):1362-73. PMID: 14973030.
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      146. Saier M. Evolution of bacterial type III protein secretion systems. Trends Microbiol. 2004 Mar; 12(3):113-5. PMID: 15001186.
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      147. von Rozycki T, Schultzel MA, Saier M. Sequence analyses of cyanobacterial bicarbonate transporters and their homologues. J Mol Microbiol Biotechnol. 2004; 7(3):102-8. PMID: 15263814.
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      148. Felce J, Saier M. Carbonic anhydrases fused to anion transporters of the SulP family: evidence for a novel type of bicarbonate transporter. J Mol Microbiol Biotechnol. 2004; 8(3):169-76. PMID: 16088218.
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      149. Chagneau C, Saier M. Biofilm-defective mutants of Bacillus subtilis. J Mol Microbiol Biotechnol. 2004; 8(3):177-88. PMID: 16088219.
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      150. von Rozycki T, Yen MR, Lende EE, Saier M. The YedZ family: possible heme binding proteins that can be fused to transporters and electron carriers. J Mol Microbiol Biotechnol. 2004; 8(3):129-40. PMID: 16088215.
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      151. Tran CV, Saier M. The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily. Microbiology. 2004 Jan; 150(Pt 1):1-3. PMID: 14702390.
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      152. Prakash S, Cooper G, Singhi S, Saier M. The ion transporter superfamily. Biochim Biophys Acta. 2003 Dec 3; 1618(1):79-92. PMID: 14643936.
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      153. Aboulwafa M, Hvorup R, Saier M. Dependency of sugar transport and phosphorylation by the phosphoenolpyruvate-dependent phosphotransferase system on membranous phosphatidylethanolamine in Escherichia coli: studies with a pssA mutant lacking phosphatidylserine synthase. Arch Microbiol. 2004 Jan; 181(1):26-34. PMID: 14634719.
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      154. Peabody CR, Chung YJ, Yen MR, Vidal-Ingigliardi D, Pugsley AP, Saier M. Type II protein secretion and its relationship to bacterial type IV pili and archaeal flagella. Microbiology. 2003 Nov; 149(Pt 11):3051-72. PMID: 14600218.
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      155. Winnen B, Hvorup RN, Saier M. The tripartite tricarboxylate transporter (TTT) family. Res Microbiol. 2003 Sep; 154(7):457-65. PMID: 14499931.
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      156. Zhai YF, Heijne W, Saier M. Molecular modeling of the bacterial outer membrane receptor energizer, ExbBD/TonB, based on homology with the flagellar motor, MotAB. Biochim Biophys Acta. 2003 Aug 7; 1614(2):201-10. PMID: 12896813.
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      157. Hua VB, Chang AB, Tchieu JH, Kumar NM, Nielsen PA, Saier M. Sequence and phylogenetic analyses of 4 TMS junctional proteins of animals: connexins, innexins, claudins and occludins. J Membr Biol. 2003 Jul 1; 194(1):59-76. PMID: 14502443.
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      158. Zhang Z, Feige JN, Chang AB, Anderson IJ, Brodianski VM, Vitreschak AG, Gelfand MS, Saier M. A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily. Arch Microbiol. 2003 Aug; 180(2):88-100. PMID: 12819857.
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      159. Saier M. Tracing pathways of transport protein evolution. Mol Microbiol. 2003 Jun; 48(5):1145-56. PMID: 12787345.
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      160. Lorca G, Winnen B, Saier M. Identification of the L-aspartate transporter in Bacillus subtilis. J Bacteriol. 2003 May; 185(10):3218-22. PMID: 12730183.
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      161. Aboulwafa M, Saier M. Soluble sugar permeases of the phosphotransferase system in Escherichia coli: evidence for two physically distinct forms of the proteins in vivo. Mol Microbiol. 2003 Apr; 48(1):131-41. PMID: 12657050.
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      162. Zhang Z, Aboulwafa M, Smith MH, Saier M. The ascorbate transporter of Escherichia coli. J Bacteriol. 2003 Apr; 185(7):2243-50. PMID: 12644495.
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      163. Ma Q, Zhai Y, Schneider JC, Ramseier TM, Saier M. Protein secretion systems of Pseudomonas aeruginosa and P fluorescens. Biochim Biophys Acta. 2003 Apr 1; 1611(1-2):223-33. PMID: 12659964.
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      164. Hvorup RN, Winnen B, Chang AB, Jiang Y, Zhou XF, Saier M. The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur J Biochem. 2003 Mar; 270(5):799-813. PMID: 12603313.
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      165. Aboulwafa M, Chung YJ, Wai HH, Saier M. Studies on the Escherichia coli glucose-specific permease, PtsG, with a point mutation in its N-terminal amphipathic leader sequence. Microbiology. 2003 Mar; 149(Pt 3):763-71. PMID: 12634344.
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      166. Pivetti CD, Yen MR, Miller S, Busch W, Tseng YH, Booth IR, Saier M. Two families of mechanosensitive channel proteins. Microbiol Mol Biol Rev. 2003 Mar; 67(1):66-85, table of contents. PMID: 12626684.
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      167. Cao TB, Saier M. The general protein secretory pathway: phylogenetic analyses leading to evolutionary conclusions. Biochim Biophys Acta. 2003 Jan 10; 1609(1):115-25. PMID: 12507766.
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      168. Minocha R, Studley K, Saier M. The urea transporter (UT) family: bioinformatic analyses leading to structural, functional, and evolutionary predictions. Receptors Channels. 2003; 9(6):345-52. PMID: 14698962.
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      169. Busch W, Saier M. The IUBMB-endorsed transporter classification system. Methods Mol Biol. 2003; 227:21-36. PMID: 12824641.
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      170. Zhou X, Yang NM, Tran CV, Hvorup RN, Saier M. Web-based programs for the display and analysis of transmembrane alpha-helices in aligned protein sequences. J Mol Microbiol Biotechnol. 2003; 5(1):1-6. PMID: 12673055.
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      171. Zhou X, Hvorup RN, Saier M. An automated program to screen databases for members of protein families. J Mol Microbiol Biotechnol. 2003; 5(1):7-10. PMID: 12673056.
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      172. Kimball RA, Martin L, Saier M. Reversing transmembrane electron flow: the DsbD and DsbB protein families. J Mol Microbiol Biotechnol. 2003; 5(3):133-49. PMID: 12766342.
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      173. Hvorup R, Chang AB, Saier M. Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family. J Mol Microbiol Biotechnol. 2003; 6(3-4):191-205. PMID: 15153772.
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      174. Hvorup RN, Saier M. Sequence similarity between the channel-forming domains of voltage-gated ion channel proteins and the C-terminal domains of secondary carriers of the major facilitator superfamily. Microbiology. 2002 Dec; 148(Pt 12):3760-2. PMID: 12480878.
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      175. Aboulwafa M, Saier M. Dependency of sugar transport and phosphorylation by the phosphoenolpyruvate-dependent phosphotransferase system on membranous phosphatidyl glycerol in Escherichia coli: studies with a pgsA mutant lacking phosphatidyl glycerophosphate synthase. Res Microbiol. 2002 Dec; 153(10):667-77. PMID: 12558186.
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      176. Greenberg DB, Stülke J, Saier M. Domain analysis of transcriptional regulators bearing PTS regulatory domains. Res Microbiol. 2002 Oct; 153(8):519-26. PMID: 12437213.
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      177. Hu KY, Saier M. Phylogeny of phosphoryl transfer proteins of the phosphoenolpyruvate-dependent sugar-transporting phosphotransferase system. Res Microbiol. 2002 Sep; 153(7):405-15. PMID: 12405346.
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      178. Zhai Y, Saier M. The beta-barrel finder (BBF) program, allowing identification of outer membrane beta-barrel proteins encoded within prokaryotic genomes. Protein Sci. 2002 Sep; 11(9):2196-207. PMID: 12192075.
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      179. Klaenhammer T, Altermann E, Arigoni F, Bolotin A, Breidt F, Broadbent J, Cano R, Chaillou S, Deutscher J, Gasson M, van de Guchte M, Guzzo J, Hartke A, Hawkins T, Hols P, Hutkins R, Kleerebezem M, Kok J, Kuipers O, Lubbers M, Maguin E, McKay L, Mills D, Nauta A, Overbeek R, Pel H, Pridmore D, Saier M, van Sinderen D, Sorokin A, Steele J, O'Sullivan D, de Vos W, Weimer B, Zagorec M, Siezen R. Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek. 2002 Aug; 82(1-4):29-58. PMID: 12369195.
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      180. Zhai Y, Saier M. A simple sensitive program for detecting internal repeats in sets of multiply aligned homologous proteins. J Mol Microbiol Biotechnol. 2002 Jul; 4(4):375-7. PMID: 12125818.
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      181. Yen MR, Peabody CR, Partovi SM, Zhai Y, Tseng YH, Saier M. Protein-translocating outer membrane porins of Gram-negative bacteria. Biochim Biophys Acta. 2002 May 3; 1562(1-2):6-31. PMID: 11988218.
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      182. Chung YJ, Saier M. Overexpression of the Escherichia coli sugE gene confers resistance to a narrow range of quaternary ammonium compounds. J Bacteriol. 2002 May; 184(9):2543-5. PMID: 11948170.
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      183. Kimball RA, Saier M. Voltage-gated H+ channels associated with human phagocyte superoxide-generating NADPH oxidases: sequence comparisons, structural predictions, and phylogenetic analyses. Mol Membr Biol. 2002 Apr-Jun; 19(2):137-47. PMID: 12126231.
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      184. Kinch LN, Saier M, Grishin NV. Sec61beta--a component of the archaeal protein secretory system. Trends Biochem Sci. 2002 Apr; 27(4):170-1. PMID: 11943537.
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      185. Yen MR, Tseng YH, Nguyen EH, Wu LF, Saier M. Sequence and phylogenetic analyses of the twin-arginine targeting (Tat) protein export system. Arch Microbiol. 2002 Jun; 177(6):441-50. PMID: 12029389.
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      186. Amar P, Ballet P, Barlovatz-Meimon G, Benecke A, Bernot G, Bouligand Y, Bourguine P, Delaplace F, Delosme JM, Demarty M, Fishov I, Fourmentin-Guilbert J, Fralick J, Giavitto JL, Gleyse B, Godin C, Incitti R, Képès F, Lange C, Le Sceller L, Loutellier C, Michel O, Molina F, Monnier C, Natowicz R, Norris V, Orange N, Pollard H, Raine D, Ripoll C, Rouviere-Yaniv J, Saier M, Soler P, Tambourin P, Thellier M, Tracqui P, Ussery D, Vincent JC, Vannier JP, Wiggins P, Zemirline A. Hyperstructures, genome analysis and I-cells. Acta Biotheor. 2002; 50(4):357-73. PMID: 12675536.
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      187. Busch W, Saier M. The transporter classification (TC) system, 2002. Crit Rev Biochem Mol Biol. 2002; 37(5):287-337. PMID: 12449427.
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      188. Zhai Y, Tchieu J, Saier M. A web-based Tree View (TV) program for the visualization of phylogenetic trees. J Mol Microbiol Biotechnol. 2002 Jan; 4(1):69-70. PMID: 11763971.
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      189. Karp PD, Riley M, Saier M, Paulsen IT, Collado-Vides J, Paley SM, Pellegrini-Toole A, Bonavides C, Gama-Castro S. The EcoCyc Database. Nucleic Acids Res. 2002 Jan 1; 30(1):56-8. PMID: 11752253.
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      190. Saier M, Goldman SR, Maile RR, Moreno MS, Weyler W, Yang N, Paulsen IT. Transport capabilities encoded within the Bacillus subtilis genome. J Mol Microbiol Biotechnol. 2002 Jan; 4(1):37-67. PMID: 11763970.
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      191. Quan JA, Schneider BL, Paulsen IT, Yamada M, Kredich NM, Saier M. Regulation of carbon utilization by sulfur availability in Escherichia coli and Salmonella typhimurium. Microbiology. 2002 Jan; 148(Pt 1):123-31. PMID: 11782505.
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      192. Yen MR, Tseng YH, Simic P, Sahm H, Eggeling L, Saier M. The ubiquitous ThrE family of putative transmembrane amino acid efflux transporters. Res Microbiol. 2002 Jan-Feb; 153(1):19-25. PMID: 11881894.
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      193. Cao TB, Saier M. Conjugal type IV macromolecular transfer systems of Gram-negative bacteria: organismal distribution, structural constraints and evolutionary conclusions. Microbiology. 2001 Dec; 147(Pt 12):3201-14. PMID: 11739753.
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      194. Yen MR, Harley KT, Tseng YH, Saier M. Phylogenetic and structural analyses of the oxa1 family of protein translocases. FEMS Microbiol Lett. 2001 Nov 13; 204(2):223-31. PMID: 11731127.
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      195. Yen MR, Tseng YH, Saier M. Maize Yellow Stripe1, an iron-phytosiderophore uptake transporter, is a member of the oligopeptide transporter (OPT) family. Microbiology. 2001 Nov; 147(Pt 11):2881-3. PMID: 11700339.
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      196. Zhai Y, Saier M. A web-based program (WHAT) for the simultaneous prediction of hydropathy, amphipathicity, secondary structure and transmembrane topology for a single protein sequence. J Mol Microbiol Biotechnol. 2001 Oct; 3(4):501-2. PMID: 11545267.
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      197. Jack DL, Yang NM, Saier M. The drug/metabolite transporter superfamily. Eur J Biochem. 2001 Jul; 268(13):3620-39. PMID: 11432728.
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      198. Saier M. The bacterial phosphotransferase system: structure, function, regulation and evolution. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):325-7. PMID: 11361062.
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      199. Faure D, Saier M, Vanderleyden J. An evolutionary alternative system for aryl beta-glucosides assimilation in bacteria. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):467-70. PMID: 11361080.
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      200. Tchieu JH, Norris V, Edwards JS, Saier M. The complete phosphotransferase system in Escherichia coli. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):329-46. PMID: 11361063.
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      201. Saier M, Paulsen IT. Phylogeny of multidrug transporters. Semin Cell Dev Biol. 2001 Jun; 12(3):205-13. PMID: 11428913.
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      202. Ab E, Schuurman-Wolters GK, Nijlant D, Dijkstra K, Saier M, Robillard GT, Scheek RM. NMR structure of cysteinyl-phosphorylated enzyme IIB of the N,N'-diacetylchitobiose-specific phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli. J Mol Biol. 2001 May 18; 308(5):993-1009. PMID: 11352587.
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      203. Djordjevic GM, Tchieu JH, Saier M. Genes involved in control of galactose uptake in Lactobacillus brevis and reconstitution of the regulatory system in Bacillus subtilis. J Bacteriol. 2001 May; 183(10):3224-36. PMID: 11325952.
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      204. Zhai Y, Heijne WH, Smith DW, Saier M. Homologues of archaeal rhodopsins in plants, animals and fungi: structural and functional predications for a putative fungal chaperone protein. Biochim Biophys Acta. 2001 Apr 2; 1511(2):206-23. PMID: 11286964.
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      205. Paulsen IT, Chen J, Nelson KE, Saier M. Comparative genomics of microbial drug efflux systems. J Mol Microbiol Biotechnol. 2001 Apr; 3(2):145-50. PMID: 11321566.
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      206. Zhai Y, Saier M. A web-based program for the prediction of average hydropathy, average amphipathicity and average similarity of multiply aligned homologous proteins. J Mol Microbiol Biotechnol. 2001 Apr; 3(2):285-6. PMID: 11321584.
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      207. Chung YJ, Saier M. SMR-type multidrug resistance pumps. Curr Opin Drug Discov Devel. 2001 Mar; 4(2):237-45. PMID: 11378963.
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      208. Moreno MS, Schneider BL, Maile RR, Weyler W, Saier M. Catabolite repression mediated by the CcpA protein in Bacillus subtilis: novel modes of regulation revealed by whole-genome analyses. Mol Microbiol. 2001 Mar; 39(5):1366-81. PMID: 11251851.
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      209. Chung YJ, Krueger C, Metzgar D, Saier M. Size comparisons among integral membrane transport protein homologues in bacteria, Archaea, and Eucarya. J Bacteriol. 2001 Feb; 183(3):1012-21. PMID: 11208800.
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      210. Saier M. Evolution of transport proteins. Genet Eng (N Y). 2001; 23:1-10. PMID: 11570098.
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      211. Schilling CH, Held L, Torre M, Saier M. GRASP-DNA: a web application to screen prokaryotic genomes for specific DNA-binding sites and repeat motifs. J Mol Microbiol Biotechnol. 2000 Oct; 2(4):495-500. PMID: 11075923.
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      212. Paulsen IT, Reizer J, Jin RZ, Lin EC, Saier M. Functional genomic studies of dihydroxyacetone utilization in Escherichia coli. Microbiology. 2000 Oct; 146 ( Pt 10):2343-4. PMID: 11021910.
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      213. Saier M, Paulsen IT. Whole genome analyses of transporters in spirochetes: Borrelia burgdorferi and Treponema pallidum. J Mol Microbiol Biotechnol. 2000 Oct; 2(4):393-9. PMID: 11075911.
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      214. Zhai Y, Saier M. The amoebapore superfamily. Biochim Biophys Acta. 2000 Sep 18; 1469(2):87-99. PMID: 10998571.
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      215. Saier M. Vectorial metabolism and the evolution of transport systems. J Bacteriol. 2000 Sep; 182(18):5029-35. PMID: 10960084.
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      216. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier M, Hancock RE, Lory S, Olson MV. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31; 406(6799):959-64. PMID: 10984043.
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      217. Paulsen IT, Nguyen L, Sliwinski MK, Rabus R, Saier M. Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes. J Mol Biol. 2000 Aug 4; 301(1):75-100. PMID: 10926494.
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      218. Saier M. Families of transmembrane transporters selective for amino acids and their derivatives. Microbiology. 2000 Aug; 146 ( Pt 8):1775-95. PMID: 10931885.
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      219. Jack DL, Paulsen IT, Saier M. The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations. Microbiology. 2000 Aug; 146 ( Pt 8):1797-814. PMID: 10931886.
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      220. Saier M. Families of proteins forming transmembrane channels. J Membr Biol. 2000 Jun 1; 175(3):165-80. PMID: 10833527.
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      221. Saier M. A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol Mol Biol Rev. 2000 Jun; 64(2):354-411. PMID: 10839820.
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      222. Nguyen L, Paulsen IT, Tchieu J, Hueck CJ, Saier M. Phylogenetic analyses of the constituents of Type III protein secretion systems. J Mol Microbiol Biotechnol. 2000 Apr; 2(2):125-44. PMID: 10939240.
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      223. Harley KT, Saier M. A novel ubiquitous family of putative efflux transporters. J Mol Microbiol Biotechnol. 2000 Apr; 2(2):195-8. PMID: 10939244.
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      224. Jack DL, Storms ML, Tchieu JH, Paulsen IT, Saier M. A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins. J Bacteriol. 2000 Apr; 182(8):2311-3. PMID: 10735877.
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      225. Harley KT, Djordjevic GM, Tseng TT, Saier M. Membrane-fusion protein homologues in gram-positive bacteria. Mol Microbiol. 2000 Apr; 36(2):516-7. PMID: 10792737.
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      226. Saier M. Families of transmembrane sugar transport proteins. Mol Microbiol. 2000 Feb; 35(4):699-710. PMID: 10692148.
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      227. Karp PD, Riley M, Saier M, Paulsen IT, Paley SM, Pellegrini-Toole A. The EcoCyc and MetaCyc databases. Nucleic Acids Res. 2000 Jan 1; 28(1):56-9. PMID: 10592180.
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      228. Rabus R, Jack DL, Kelly DJ, Saier M. TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology. 1999 Dec; 145 ( Pt 12):3431-45. PMID: 10627041.
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      229. Reizer J, Bachem S, Reizer A, Arnaud M, Saier M, Stülke J. Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis. Microbiology. 1999 Dec; 145 ( Pt 12):3419-29. PMID: 10627040.
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      230. Verrey F, Jack DL, Paulsen IT, Saier M, Pfeiffer R. New glycoprotein-associated amino acid transporters. J Membr Biol. 1999 Dec 1; 172(3):181-92. PMID: 10568788.
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      231. Saier M, Beatty JT, Goffeau A, Harley KT, Heijne WH, Huang SC, Jack DL, Jähn PS, Lew K, Liu J, Pao SS, Paulsen IT, Tseng TT, Virk PS. The major facilitator superfamily. J Mol Microbiol Biotechnol. 1999 Nov; 1(2):257-79. PMID: 10943556.
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      232. Vrljic M, Garg J, Bellmann A, Wachi S, Freudl R, Malecki MJ, Sahm H, Kozina VJ, Eggeling L, Saier MH, Eggeling L, Saier MH. The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute translocators. J Mol Microbiol Biotechnol. 1999 Nov; 1(2):327-36. PMID: 10943564.
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      233. Saier M, Paulsen IT. Paralogous genes encoding transport proteins in microbial genomes. Res Microbiol. 1999 Nov-Dec; 150(9-10):689-99. PMID: 10673007.
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      234. Reizer J, Reizer A, Lagrou MJ, Folger KR, Stover CK, Saier M. Novel phosphotransferase systems revealed by bacterial genome analysis: the complete repertoire of pts genes in Pseudomonas aeruginosa. J Mol Microbiol Biotechnol. 1999 Nov; 1(2):289-93. PMID: 10943558.
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      235. Nelson RD, Kuan G, Saier M, Montal M. Modular assembly of voltage-gated channel proteins: a sequence analysis and phylogenetic study. J Mol Microbiol Biotechnol. 1999 Nov; 1(2):281-7. PMID: 10943557.
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      236. Saier M. Genome archeology leading to the characterization and classification of transport proteins. Curr Opin Microbiol. 1999 Oct; 2(5):555-61. PMID: 10508720.
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      237. Rabus R, Reizer J, Paulsen I, Saier M. Enzyme I(Ntr) from Escherichia coli. A novel enzyme of the phosphoenolpyruvate-dependent phosphotransferase system exhibiting strict specificity for its phosphoryl acceptor, NPr. J Biol Chem. 1999 Sep 10; 274(37):26185-91. PMID: 10473571.
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      238. Tseng TT, Gratwick KS, Kollman J, Park D, Nies DH, Goffeau A, Saier M. The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J Mol Microbiol Biotechnol. 1999 Aug; 1(1):107-25. PMID: 10941792.
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      239. Saier M, Kollman JM. Is FatP a long-chain fatty acid transporter? Mol Microbiol. 1999 Aug; 33(3):670-2. PMID: 10417658.
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      240. Dassa E, Hofnung M, Paulsen IT, Saier M. The Escherichia coli ABC transporters: an update. Mol Microbiol. 1999 May; 32(4):887-9. PMID: 10361292.
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      241. Reizer J, Schneider B, Reizer A, Saier M. A hybrid response regulator possessing a PEP-dependent phosphorylation domain. Microbiology. 1999 May; 145 ( Pt 5):987-9. PMID: 10376812.
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      242. Le T, Tseng TT, Saier M. Flexible programs for the prediction of average amphipathicity of multiply aligned homologous proteins: application to integral membrane transport proteins. Mol Membr Biol. 1999 Apr-Jun; 16(2):173-9. PMID: 10417982.
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      243. Youderian P, Lawes MC, Creighton C, Cook JC, Saier M. Mutations that confer resistance to 2-deoxyglucose reduce the specific activity of hexokinase from Myxococcus xanthus. J Bacteriol. 1999 Apr; 181(7):2225-35. PMID: 10094702.
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      244. Norris V, Gascuel P, Guespin-Michel J, Ripoll C, Saier M. Metabolite-induced metabolons: the activation of transporter-enzyme complexes by substrate binding. Mol Microbiol. 1999 Mar; 31(5):1592-5. PMID: 10200976.
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      245. Saier M, Eng BH, Fard S, Garg J, Haggerty DA, Hutchinson WJ, Jack DL, Lai EC, Liu HJ, Nusinew DP, Omar AM, Pao SS, Paulsen IT, Quan JA, Sliwinski M, Tseng TT, Wachi S, Young GB. Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochim Biophys Acta. 1999 Feb 25; 1422(1):1-56. PMID: 10082980.
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      246. Young GB, Jack DL, Smith DW, Saier M. The amino acid/auxin:proton symport permease family. Biochim Biophys Acta. 1999 Jan 8; 1415(2):306-22. PMID: 9889387.
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      247. Saier M. Eukaryotic transmembrane solute transport systems. Int Rev Cytol. 1999; 190:61-136. PMID: 10331239.
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      248. Saier M. A functional-phylogenetic system for the classification of transport proteins. J Cell Biochem. 1999; Suppl 32-33:84-94. PMID: 10629107.
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      249. Studley WK, Yamaguchi M, Hatefi Y, Saier M. Phylogenetic analyses of proton-translocating transhydrogenases. Microb Comp Genomics. 1999; 4(3):173-86. PMID: 10587945.
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      250. Eng BH, Guerinot ML, Eide D, Saier M. Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins. J Membr Biol. 1998 Nov 1; 166(1):1-7. PMID: 9784581.
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      251. Nies DH, Koch S, Wachi S, Peitzsch N, Saier M. CHR, a novel family of prokaryotic proton motive force-driven transporters probably containing chromate/sulfate antiporters. J Bacteriol. 1998 Nov; 180(21):5799-802. PMID: 9791139.
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      252. Garrity LF, Schiel SL, Merrill R, Reizer J, Saier M, Ordal GW. Unique regulation of carbohydrate chemotaxis in Bacillus subtilis by the phosphoenolpyruvate-dependent phosphotransferase system and the methyl-accepting chemotaxis protein McpC. J Bacteriol. 1998 Sep; 180(17):4475-80. PMID: 9721285.
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      253. Saier M. Genome sequencing and informatics: new tools for biochemical discoveries. Plant Physiol. 1998 Aug; 117(4):1129-33. PMID: 9701568.
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      254. Paulsen IT, Sliwinski MK, Nelissen B, Goffeau A, Saier M. Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. FEBS Lett. 1998 Jun 23; 430(1-2):116-25. PMID: 9678606.
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      255. Bordo D, van Monfort RL, Pijning T, Kalk KH, Reizer J, Saier M, Dijkstra BW. The three-dimensional structure of the nitrogen regulatory protein IIANtr from Escherichia coli. J Mol Biol. 1998 May 29; 279(1):245-55. PMID: 9636714.
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      256. Chen Y, Case DA, Reizer J, Saier M, Wright PE. High-resolution solution structure of Bacillus subtilis IIAglc. Proteins. 1998 May 15; 31(3):258-70. PMID: 9593197.
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      257. Paulsen IT, Sliwinski MK, Saier M. Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities. J Mol Biol. 1998 Apr 3; 277(3):573-92. PMID: 9533881.
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      258. Saier M. Multiple mechanisms controlling carbon metabolism in bacteria. Biotechnol Bioeng. 1998 Apr 20-May 5; 58(2-3):170-4. PMID: 10191387.
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      259. Reizer J, Hoischen C, Titgemeyer F, Rivolta C, Rabus R, Stülke J, Karamata D, Saier M, Hillen W. A novel protein kinase that controls carbon catabolite repression in bacteria. Mol Microbiol. 1998 Mar; 27(6):1157-69. PMID: 9570401.
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      260. Saier M, Paulsen IT, Sliwinski MK, Pao SS, Skurray RA, Nikaido H. Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J. 1998 Mar; 12(3):265-74. PMID: 9506471.
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      261. Pao SS, Paulsen IT, Saier M. Major facilitator superfamily. Microbiol Mol Biol Rev. 1998 Mar; 62(1):1-34. PMID: 9529885.
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      262. Chauvaux S, Paulsen IT, Saier M. CcpB, a novel transcription factor implicated in catabolite repression in Bacillus subtilis. J Bacteriol. 1998 Feb; 180(3):491-7. PMID: 9457849.
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      263. Paulsen IT, Chauvaux S, Choi P, Saier M. Characterization of glucose-specific catabolite repression-resistant mutants of Bacillus subtilis: identification of a novel hexose:H+ symporter. J Bacteriol. 1998 Feb; 180(3):498-504. PMID: 9457850.
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      264. Saier M. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv Microb Physiol. 1998; 40:81-136. PMID: 9889977.
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      265. Rajagopal P, Waygood EB, Reizer J, Saier M, Klevit RE. Demonstration of protein-protein interaction specificity by NMR chemical shift mapping. Protein Sci. 1997 Dec; 6(12):2624-7. PMID: 9416611.
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      266. Paulsen IT, Park JH, Choi PS, Saier M. A family of gram-negative bacterial outer membrane factors that function in the export of proteins, carbohydrates, drugs and heavy metals from gram-negative bacteria. FEMS Microbiol Lett. 1997 Nov 1; 156(1):1-8. PMID: 9368353.
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      267. Reizer J, Reizer A, Saier M. Is the ribulose monophosphate pathway widely distributed in bacteria? Microbiology. 1997 Aug; 143 ( Pt 8):2519-20. PMID: 9274005.
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      268. Paulsen IT, Beness AM, Saier M. Computer-based analyses of the protein constituents of transport systems catalysing export of complex carbohydrates in bacteria. Microbiology. 1997 Aug; 143 ( Pt 8):2685-99. PMID: 9274022.
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      269. Tortosa P, Aymerich S, Lindner C, Saier M, Reizer J, Le Coq D. Multiple phosphorylation of SacY, a Bacillus subtilis transcriptional antiterminator negatively controlled by the phosphotransferase system. J Biol Chem. 1997 Jul 4; 272(27):17230-7. PMID: 9202047.
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      270. Loveless BJ, Saier M. A novel family of channel-forming, autotransporting, bacterial virulence factors. Mol Membr Biol. 1997 Jul-Sep; 14(3):113-23. PMID: 9394291.
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      271. Reizer J, Saier M. Modular multidomain phosphoryl transfer proteins of bacteria. Curr Opin Struct Biol. 1997 Jun; 7(3):407-15. PMID: 9204284.
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      272. Pao GM, Saier M. Nonplastid eukaryotic response regulators have a monophyletic origin and evolved from their bacterial precursors in parallel with their cognate sensor kinases. J Mol Evol. 1997 Jun; 44(6):605-13. PMID: 9169552.
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      273. Dagnall BH, Saier M. HatA and HatR, implicated in the uptake of inorganic carbon in Synechocystis PCC6803, contain WD40 domains. Mol Microbiol. 1997 Apr; 24(1):229-30. PMID: 9140979.
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      274. Paulsen IT, Saier M. A novel family of ubiquitous heavy metal ion transport proteins. J Membr Biol. 1997 Mar 15; 156(2):99-103. PMID: 9075641.
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      275. Crasnier-Mednansky M, Park MC, Studley WK, Saier M. Cra-mediated regulation of Escherichia coli adenylate cyclase. Microbiology. 1997 Mar; 143 ( Pt 3):785-92. PMID: 9084162.
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      276. Peekhaus N, Tong S, Reizer J, Saier M, Murray E, Conway T. Characterization of a novel transporter family that includes multiple Escherichia coli gluconate transporters and their homologues. FEMS Microbiol Lett. 1997 Feb 15; 147(2):233-8. PMID: 9119199.
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      277. Ab E, Schuurman-Wolters G, Reizer J, Saier M, Dijkstra K, Scheek RM, Robillard GT. The NMR side-chain assignments and solution structure of enzyme IIBcellobiose of the phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli. Protein Sci. 1997 Feb; 6(2):304-14. PMID: 9041631.
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      278. Goffeau A, Park J, Paulsen IT, Jonniaux JL, Dinh T, Mordant P, Saier M. Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily. Yeast. 1997 Jan; 13(1):43-54. PMID: 9046086.
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      279. Saier M, Paulsen IT, Matin A. A bacterial model system for understanding multi-drug resistance. Microb Drug Resist. 1997; 3(4):289-95. PMID: 9442481.
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      280. Reizer J, Reizer A, Perego M, Saier M. Characterization of a family of bacterial response regulator aspartyl-phosphate (RAP) phosphatases. Microb Comp Genomics. 1997; 2(2):103-11. PMID: 9689219.
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      281. Reizer J, Reizer A, Merrick MJ, Plunkett G, Rose DJ, Saier M. Novel phosphotransferase-encoding genes revealed by analysis of the Escherichia coli genome: a chimeric gene encoding an Enzyme I homologue that possesses a putative sensory transduction domain. Gene. 1996 Nov 28; 181(1-2):103-8. PMID: 8973315.
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      282. Warrington RC, Fang WD, Zhang L, Shieh M, Saier M. Mimetics of L-histidinol which selectively modulate daunomycin toxicity in normal and tumorigenic epithelial cells. Anticancer Res. 1996 Nov-Dec; 16(6B):3635-9. PMID: 9042234.
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      283. Warrington RC, Fang WD, Zhang L, Shieh M, Saier M. L-histidinol selectively modulates daunomycin toxicity in normal and tumorigenic kidney epithelial cells. Anticancer Res. 1996 Nov-Dec; 16(6B):3629-33. PMID: 9042233.
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      284. Reizer J, Mitchell WJ, Minton N, Brehm J, Reizer A, Saier M. Proposed topology of the glucitol permeases of Escherichia coli and Clostridium acetobutylicum. Curr Microbiol. 1996 Nov; 33(5):331-3. PMID: 8875915.
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      285. Park JH, Saier M. Phylogenetic characterization of the MIP family of transmembrane channel proteins. J Membr Biol. 1996 Oct; 153(3):171-80. PMID: 8849412.
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      286. Ramseier TM, Chien SY, Saier M. Cooperative interaction between Cra and Fnr in the regulation of the cydAB operon of Escherichia coli. Curr Microbiol. 1996 Oct; 33(4):270-4. PMID: 8824175.
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      287. Naderi S, Saier M. Plant sucrose:H+ symporters are homologous to the melibiose permease of Escherichia coli. Mol Microbiol. 1996 Oct; 22(2):390-1. PMID: 8930923.
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      288. Hoischen C, Levin J, Pitaknarongphorn S, Reizer J, Saier M. Involvement of the central loop of the lactose permease of Escherichia coli in its allosteric regulation by the glucose-specific enzyme IIA of the phosphoenolpyruvate-dependent phosphotransferase system. J Bacteriol. 1996 Oct; 178(20):6082-6. PMID: 8830713.
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      289. Macfadyen LP, Dorocicz IR, Reizer J, Saier M, Redfield RJ. Regulation of competence development and sugar utilization in Haemophilus influenzae Rd by a phosphoenolpyruvate:fructose phosphotransferase system. Mol Microbiol. 1996 Sep; 21(5):941-52. PMID: 8885265.
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      290. Reizer J, Bergstedt U, Galinier A, Küster E, Saier M, Hillen W, Steinmetz M, Deutscher J. Catabolite repression resistance of gnt operon expression in Bacillus subtilis conferred by mutation of His-15, the site of phosphoenolpyruvate-dependent phosphorylation of the phosphocarrier protein HPr. J Bacteriol. 1996 Sep; 178(18):5480-6. PMID: 8808939.
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      291. Arnaud M, Débarbouillé M, Rapoport G, Saier M, Reizer J. In vitro reconstitution of transcriptional antitermination by the SacT and SacY proteins of Bacillus subtilis. J Biol Chem. 1996 Aug 2; 271(31):18966-72. PMID: 8702561.
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      292. Le T, Saier M. Phylogenetic characterization of the epithelial Na+ channel (ENaC) family. Mol Membr Biol. 1996 Jul-Sep; 13(3):149-57. PMID: 8905643.
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      293. Saier M, Crasnier M. Inducer exclusion and the regulation of sugar transport. Res Microbiol. 1996 Jul-Sep; 147(6-7):482-9. PMID: 9084759.
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      294. Saier M. Regulatory interactions controlling carbon metabolism: an overview. Res Microbiol. 1996 Jul-Sep; 147(6-7):439-47. PMID: 9084753.
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      295. Nguyen CC, Saier M. Structural and phylogenetic analysis of the MotA and MotB families of bacterial flagellar motor proteins. Res Microbiol. 1996 Jun; 147(5):317-32. PMID: 8763618.
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      296. Ye JJ, Saier M. Regulation of sugar uptake via the phosphoenolpyruvate-dependent phosphotransferase systems in Bacillus subtilis and Lactococcus lactis is mediated by ATP-dependent phosphorylation of seryl residue 46 in HPr. J Bacteriol. 1996 Jun; 178(12):3557-63. PMID: 8655554.
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      297. Saier M, Ramseier TM. The catabolite repressor/activator (Cra) protein of enteric bacteria. J Bacteriol. 1996 Jun; 178(12):3411-7. PMID: 8655535.
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      298. Reizer J, Reizer A, Saier M. Novel PTS proteins revealed by bacterial genome sequencing: a unique fructose-specific phosphoryl transfer protein with two HPr-like domains in Haemophilus influenzae. Res Microbiol. 1996 May; 147(4):209-15. PMID: 8763608.
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      299. Saier M. Cyclic AMP-independent catabolite repression in bacteria. FEMS Microbiol Lett. 1996 May 1; 138(2-3):97-103. PMID: 9026456.
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      300. Charbit A, Reizer J, Saier M. Function of the duplicated IIB domain and oligomeric structure of the fructose permease of Escherichia coli. J Biol Chem. 1996 Apr 26; 271(17):9997-10003. PMID: 8626640.
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      301. Du Y, Holtel A, Reizer J, Saier M. sigma54-dependent transcription of the Pseudomonas putida xylS operon is influenced by the IIANtr protein of the phosphotransferase system in Escherichia coli. Res Microbiol. 1996 Mar-Apr; 147(3):129-32. PMID: 8761731.
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      302. Paulsen IT, Skurray RA, Tam R, Saier M, Turner RJ, Weiner JH, Goldberg EB, Grinius LL. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol Microbiol. 1996 Mar; 19(6):1167-75. PMID: 8730859.
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      303. Ye JJ, Minarcik J, Saier M. Inducer expulsion and the occurrence of an HPr(Ser-P)-activated sugar-phosphate phosphatase in Enterococcus faecalis and Streptococcus pyogenes. Microbiology. 1996 Mar; 142 ( Pt 3):585-92. PMID: 8868433.
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      304. Saier M, Chauvaux S, Cook GM, Deutscher J, Paulsen IT, Reizer J, Ye JJ. Catabolite repression and inducer control in Gram-positive bacteria. Microbiology. 1996 Feb; 142 ( Pt 2):217-30. PMID: 8932696.
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      305. Reizer J, Ramseier TM, Reizer A, Charbit A, Saier M. Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli. Microbiology. 1996 Feb; 142 ( Pt 2):231-50. PMID: 8932697.
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      306. Park JH, Saier M. Phylogenetic, structural and functional characteristics of the Na-K-Cl cotransporter family. J Membr Biol. 1996 Feb; 149(3):161-8. PMID: 8801348.
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      307. Koch S, Sutrina SL, Wu LF, Reizer J, Schnetz K, Rak B, Saier M. Identification of a site in the phosphocarrier protein, HPr, which influences its interactions with sugar permeases of the bacterial phosphotransferase system: kinetic analyses employing site-specific mutants. J Bacteriol. 1996 Feb; 178(4):1126-33. PMID: 8576048.
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      308. Blair A, Ngo L, Park J, Paulsen IT, Saier M. Phylogenetic analyses of the homologous transmembrane channel-forming proteins of the F0F1-ATPases of bacteria, chloroplasts and mitochondria. Microbiology. 1996 Jan; 142 ( Pt 1):17-32. PMID: 8581162.
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      309. Tsang S, Saier M. A simple flexible program for the computational analysis of amino acyl residue distribution in proteins: application to the distribution of aromatic versus aliphatic hydrophobic amino acids in transmembrane alpha-helical spanners of integral membrane transport proteins. J Comput Biol. 1996; 3(1):185-90. PMID: 8697235.
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      310. Saier M, Ye JJ, Klinke S, Nino E. Identification of an anaerobically induced phosphoenolpyruvate-dependent fructose-specific phosphotransferase system and evidence for the Embden-Meyerhof glycolytic pathway in the heterofermentative bacterium Lactobacillus brevis. J Bacteriol. 1996 Jan; 178(1):314-6. PMID: 8550437.
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      311. Bledig SA, Ramseier TM, Saier M. Frur mediates catabolite activation of pyruvate kinase (pykF) gene expression in Escherichia coli. J Bacteriol. 1996 Jan; 178(1):280-3. PMID: 8550429.
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      312. Saier M. Phylogenetic approaches to the identification and characterization of protein families and superfamilies. Microb Comp Genomics. 1996; 1(3):129-50. PMID: 9689209.
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      313. Reizer J, Paulsen IT, Reizer A, Titgemeyer F, Saier M. Novel phosphotransferase system genes revealed by bacterial genome analysis: the complete complement of pts genes in mycoplasma genitalium. Microb Comp Genomics. 1996; 1(3):151-64. PMID: 9689210.
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      314. Nguyen CC, Saier M. Phylogenetic, structural and functional analyses of the LacI-GalR family of bacterial transcription factors. FEBS Lett. 1995 Dec 18; 377(2):98-102. PMID: 8543068.
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      315. Pullen K, Rajagopal P, Branchini BR, Huffine ME, Reizer J, Saier M, Scholtz JM, Klevit RE. Phosphorylation of serine-46 in HPr, a key regulatory protein in bacteria, results in stabilization of its solution structure. Protein Sci. 1995 Dec; 4(12):2478-86. PMID: 8580838.
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      316. Cook GM, Ye JJ, Russell JB, Saier M. Properties of two sugar phosphate phosphatases from Streptococcus bovis and their potential involvement in inducer expulsion. J Bacteriol. 1995 Dec; 177(23):7007-9. PMID: 7592500.
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      317. Nguyen CC, Saier M. Phylogenetic analysis of the putative phosphorylation domain in the pyruvate kinase of Bacillus stearothermophilus. Res Microbiol. 1995 Nov-Dec; 146(9):713-9. PMID: 8584793.
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      318. Dagnall BH, Paulsen IT, Saier M. The DAG family of glycosyl hydrolases combines two previously identified protein families. Biochem J. 1995 Oct 1; 311 ( Pt 1):349-50. PMID: 7575475.
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      319. Vartak NB, Lin CC, Cleary JM, Fagan MJ, Saier M. Glucose metabolism in 'Sphingomonas elodea': pathway engineering via construction of a glucose-6-phosphate dehydrogenase insertion mutant. Microbiology. 1995 Sep; 141 ( Pt 9):2339-50. PMID: 7496544.
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      320. Cook GM, Kearns DB, Russell JB, Reizer J, Saier M. Regulation of the lactose phosphotransferase system of Streptococcus bovis by glucose: independence of inducer exclusion and expulsion mechanisms. Microbiology. 1995 Sep; 141 ( Pt 9):2261-9. PMID: 7496538.
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      321. Ramseier TM, Saier M. cAMP-cAMP receptor protein complex: five binding sites in the control region of the Escherichia coli mannitol operon. Microbiology. 1995 Aug; 141 ( Pt 8):1901-7. PMID: 7551052.
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      322. Ye JJ, Saier M. Purification and characterization of a small membrane-associated sugar phosphate phosphatase that is allosterically activated by HPr(Ser(P)) of the phosphotransferase system in Lactococcus lactis. J Biol Chem. 1995 Jul 14; 270(28):16740-4. PMID: 7622485.
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      323. Saier M, Chauvaux S, Deutscher J, Reizer J, Ye JJ. Protein phosphorylation and regulation of carbon metabolism in gram-negative versus gram-positive bacteria. Trends Biochem Sci. 1995 Jul; 20(7):267-71. PMID: 7667879.
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      324. Ramseier TM, Reizer J, Küster E, Hillen W, Saier M. In vitro binding of the CcpA protein of Bacillus megaterium to cis-acting catabolite responsive elements (CREs) of gram-positive bacteria. FEMS Microbiol Lett. 1995 Jun 15; 129(2-3):207-13. PMID: 7607401.
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      325. Ramseier TM, Inui M, Saier M. CarRS of Azospirillum brasilense is homologous to a large family of aldehyde dehydrogenases rather than to two-component regulators. Res Microbiol. 1995 Jun; 146(5):425-9. PMID: 8525059.
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      326. Ramseier TM, Bledig S, Michotey V, Feghali R, Saier M. The global regulatory protein FruR modulates the direction of carbon flow in Escherichia coli. Mol Microbiol. 1995 Jun; 16(6):1157-69. PMID: 8577250.
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      327. Tsai MH, Saier M. Phylogenetic characterization of the ubiquitous electron transfer flavoprotein families ETF-alpha and ETF-beta. Res Microbiol. 1995 Jun; 146(5):397-404. PMID: 8525056.
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      328. Kuan G, Dassa E, Saurin W, Hofnung M, Saier M. Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases. Res Microbiol. 1995 May; 146(4):271-8. PMID: 7569321.
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      329. Espanol MJ, Saier M. Topological and segmental phylogenetic analyses of the anion exchanger (band 3) family of transporters. Mol Membr Biol. 1995 Apr-Jun; 12(2):193-200. PMID: 7795710.
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      330. Reizer J, Reizer A, Saier M. Novel phosphotransferase system genes revealed by bacterial genome analysis--a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system. Microbiology. 1995 Apr; 141 ( Pt 4):961-71. PMID: 7773398.
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      331. Ye JJ, Saier M. Allosteric regulation of the glucose:H+ symporter of Lactobacillus brevis: cooperative binding of glucose and HPr(ser-P). J Bacteriol. 1995 Apr; 177(7):1900-2. PMID: 7896720.
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      332. Saier M. Differential codon usage: a safeguard against inappropriate expression of specialized genes? FEBS Lett. 1995 Mar 27; 362(1):1-4. PMID: 7535249.
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      333. Powell BS, Court DL, Inada T, Nakamura Y, Michotey V, Cui X, Reizer A, Saier M, Reizer J. Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant. J Biol Chem. 1995 Mar 3; 270(9):4822-39. PMID: 7876255.
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      334. Ryu S, Ramseier TM, Michotey V, Saier M, Garges S. Effect of the FruR regulator on transcription of the pts operon in Escherichia coli. J Biol Chem. 1995 Feb 10; 270(6):2489-96. PMID: 7852310.
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      335. Pao GM, Saier M. Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution. J Mol Evol. 1995 Feb; 40(2):136-54. PMID: 7699720.
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      336. Reizer J, Reizer A, Saier M. Sorbose-1-P reductase (SorE) and the glucitol-6-P dehydrogenase (SorD) of the Klebsiella pneumoniae L-sorbose operon belong to the zinc-dependent dehydrogenase family and the short chain alcohol dehydrogenase family, respectively. Res Microbiol. 1995 Feb; 146(2):183-4. PMID: 7652212.
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      337. Ye JJ, Saier M. Cooperative binding of lactose and the phosphorylated phosphocarrier protein HPr(Ser-P) to the lactose/H+ symport permease of Lactobacillus brevis. Proc Natl Acad Sci U S A. 1995 Jan 17; 92(2):417-21. PMID: 7831302.
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      338. Titgemeyer F, Reizer J, Reizer A, Tang J, Parr TR, Saier M. Nucleotide sequence of the region between crr and cysM in Salmonella typhimurium: five novel ORFs including one encoding a putative transcriptional regulator of the phosphotransferase system. DNA Seq. 1995; 5(3):145-52. PMID: 7612925.
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      339. Titgemeyer F, Walkenhorst J, Reizer J, Stuiver MH, Cui X, Saier M. Identification and characterization of phosphoenolpyruvate:fructose phosphotransferase systems in three Streptomyces species. Microbiology. 1995 Jan; 141 ( Pt 1):51-8. PMID: 7894719.
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      340. Ye JJ, Reizer J, Saier M. Regulation of 2-deoxyglucose phosphate accumulation in Lactococcus lactis vesicles by metabolite-activated, ATP-dependent phosphorylation of serine-46 in HPr of the phosphotransferase system. Microbiology. 1994 Dec; 140 ( Pt 12):3421-9. PMID: 7881559.
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      341. Saier M. Bacterial protein kinases that recognize tertiary rather than primary structure? Res Microbiol. 1994 Nov-Dec; 145(9):647-50. PMID: 7746953.
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      342. Pao GM, Saier M. The N-terminal, putative, mitochondrial targeting domain of the mitochondrial genome maintenance protein (MGM1) in yeast is homologous to the bacterial ribonuclease inhibitor, barstar. Mol Biol Evol. 1994 Nov; 11(6):964-5. PMID: 7815934.
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      343. Saier M, Reizer J. The bacterial phosphotransferase system: new frontiers 30 years later. Mol Microbiol. 1994 Sep; 13(5):755-64. PMID: 7815935.
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      344. Titgemeyer F, Reizer J, Reizer A, Saier M. Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria. Microbiology. 1994 Sep; 140 ( Pt 9):2349-54. PMID: 7952186.
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      345. Hueck CJ, Hillen W, Saier M. Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria. Res Microbiol. 1994 Sep; 145(7):503-18. PMID: 7855437.
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      346. Isaacs H, Chao D, Yanofsky C, Saier M. Mechanism of catabolite repression of tryptophanase synthesis in Escherichia coli. Microbiology. 1994 Aug; 140 ( Pt 8):2125-34. PMID: 7921262.
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      347. Dinh T, Paulsen IT, Saier M. A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. J Bacteriol. 1994 Jul; 176(13):3825-31. PMID: 8021163.
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      348. Reizer J, Reizer A, Saier M. A functional superfamily of sodium/solute symporters. Biochim Biophys Acta. 1994 Jun 29; 1197(2):133-66. PMID: 8031825.
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      349. van Montfort RL, Pijning T, Kalk KH, Schuurman-Wolters GK, Reizer J, Saier M, Robillard G, Dijkstra BW. Crystallization of enzyme IIB of the cellobiose-specific phosphotransferase system of Escherichia coli. J Mol Biol. 1994 Jun 17; 239(4):588-90. PMID: 8006971.
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      350. Ye JJ, Neal JW, Cui X, Reizer J, Saier M. Regulation of the glucose:H+ symporter by metabolite-activated ATP-dependent phosphorylation of HPr in Lactobacillus brevis. J Bacteriol. 1994 Jun; 176(12):3484-92. PMID: 8206825.
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      351. Pao GM, Tam R, Lipschitz LS, Saier M. Response regulators: structure, function and evolution. Res Microbiol. 1994 Jun-Aug; 145(5-6):356-62. PMID: 7855420.
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      352. Saier M. Bacterial sensor kinase/response regulator systems: an introduction. Res Microbiol. 1994 Jun-Aug; 145(5-6):349-55. PMID: 7855419.
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      353. Deutscher J, Reizer J, Fischer C, Galinier A, Saier M, Steinmetz M. Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis. J Bacteriol. 1994 Jun; 176(11):3336-44. PMID: 8195089.
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      354. Cortay JC, Nègre D, Scarabel M, Ramseier TM, Vartak NB, Reizer J, Saier M, Cozzone AJ. In vitro asymmetric binding of the pleiotropic regulatory protein, FruR, to the ace operator controlling glyoxylate shunt enzyme synthesis. J Biol Chem. 1994 May 27; 269(21):14885-91. PMID: 8195118.
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      355. Kuan G, Saier M. Phylogenetic relationships among bacteriorhodopsins. Res Microbiol. 1994 May; 145(4):273-85. PMID: 7997641.
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      356. Reizer J, Buskirk S, Bairoch A, Reizer A, Saier M. A novel zinc-binding motif found in two ubiquitous deaminase families. Protein Sci. 1994 May; 3(5):853-6. PMID: 8061614.
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      357. Reizer J, Reizer A, Kornberg HL, Saier M. Sequence of the fruB gene of Escherichia coli encoding the diphosphoryl transfer protein (DTP) of the phosphoenolpyruvate: sugar phosphotransferase system. FEMS Microbiol Lett. 1994 May 1; 118(1-2):159-62. PMID: 8013873.
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      358. Ye JJ, Reizer J, Cui X, Saier M. Inhibition of the phosphoenolpyruvate:lactose phosphotransferase system and activation of a cytoplasmic sugar-phosphate phosphatase in Lactococcus lactis by ATP-dependent metabolite-activated phosphorylation of serine 46 in the phosphocarrier protein HPr. J Biol Chem. 1994 Apr 22; 269(16):11837-44. PMID: 8163482.
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      359. Maurel C, Reizer J, Schroeder JI, Chrispeels MJ, Saier M. Functional characterization of the Escherichia coli glycerol facilitator, GlpF, in Xenopus oocytes. J Biol Chem. 1994 Apr 22; 269(16):11869-72. PMID: 7512955.
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      360. Ye JJ, Reizer J, Cui X, Saier M. ATP-dependent phosphorylation of serine-46 in the phosphocarrier protein HPr regulates lactose/H+ symport in Lactobacillus brevis. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3102-6. PMID: 8159711.
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      361. Saier M. Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution. Microbiol Rev. 1994 Mar; 58(1):71-93. PMID: 8177172.
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      362. Reizer J, Michotey V, Reizer A, Saier M. Novel phosphotransferase system genes revealed by bacterial genome analysis: unique, putative fructose- and glucoside-specific systems. Protein Sci. 1994 Mar; 3(3):440-50. PMID: 8019415.
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      363. Saier M, Tam R, Reizer A, Reizer J. Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol Microbiol. 1994 Mar; 11(5):841-7. PMID: 8022262.
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      364. Ab E, Schuurman-Wolters GK, Saier M, Reizer J, Jacuinod M, Roepstorff P, Dijkstra K, Scheek RM, Robillard GT. Enzyme IIBcellobiose of the phosphoenol-pyruvate-dependent phosphotransferase system of Escherichia coli: backbone assignment and secondary structure determined by three-dimensional NMR spectroscopy. Protein Sci. 1994 Feb; 3(2):282-90. PMID: 8003964.
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      365. Figge RM, Ramseier TM, Saier M. The mannitol repressor (MtlR) of Escherichia coli. J Bacteriol. 1994 Feb; 176(3):840-7. PMID: 8300537.
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      366. Titgemeyer F, Walkenhorst J, Cui X, Reizer J, Saier M. Proteins of the phosphoenolpyruvate:sugar phosphotransferase system in Streptomyces: possible involvement in the regulation of antibiotic production. Res Microbiol. 1994 Feb; 145(2):89-92. PMID: 8090996.
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      367. Saier M. Protein uptake into E. coli during Bdellovibrio infection. A process of reverse secretion? FEBS Lett. 1994 Jan 3; 337(1):14-7. PMID: 8276104.
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      368. Titgemeyer F, Mason RE, Saier M. Regulation of the raffinose permease of Escherichia coli by the glucose-specific enzyme IIA of the phosphoenolpyruvate:sugar phosphotransferase system. J Bacteriol. 1994 Jan; 176(2):543-6. PMID: 8288553.
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      369. Ramseier TM, Figge RM, Saier M. DNA sequence of a gene in Escherichia coli encoding a putative tripartite transcription factor with receiver, ATPase and DNA binding domains. DNA Seq. 1994; 5(1):17-24. PMID: 7894055.
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      370. Saier M. Convergence and divergence in the evolution of transport proteins. Bioessays. 1994 Jan; 16(1):23-9. PMID: 7511376.
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      371. Fagan MJ, Saier M. P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees. J Mol Evol. 1994 Jan; 38(1):57-99. PMID: 8151716.
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      372. Reizer A, Saier M, Reizer J. Classification and function prediction of proteins using diagnostic amino acid patterns. Methods Mol Biol. 1994; 25:295-305. PMID: 8004172.
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      373. Ramseier TM, Nègre D, Cortay JC, Scarabel M, Cozzone AJ, Saier M. In vitro binding of the pleiotropic transcriptional regulatory protein, FruR, to the fru, pps, ace, pts and icd operons of Escherichia coli and Salmonella typhimurium. J Mol Biol. 1993 Nov 5; 234(1):28-44. PMID: 8230205.
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      374. Hoischen C, Dijkstra A, Rottem S, Reizer J, Saier M. Presence of protein constituents of the gram-positive bacterial phosphotransferase regulatory system in Acholeplasma laidlawii. J Bacteriol. 1993 Oct; 175(20):6599-604. PMID: 8407837.
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      375. Kuan J, Saier M. Expansion of the mitochondrial carrier family. Res Microbiol. 1993 Oct; 144(8):671-2. PMID: 8140286.
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      376. Van Rosmalen M, Saier M. Structural and evolutionary relationships between two families of bacterial extracytoplasmic chaperone proteins which function cooperatively in fimbrial assembly. Res Microbiol. 1993 Sep; 144(7):507-27. PMID: 7906046.
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      377. Reizer J, Reizer A, Saier M, Bork P, Sander C. Exopolyphosphate phosphatase and guanosine pentaphosphate phosphatase belong to the sugar kinase/actin/hsp 70 superfamily. Trends Biochem Sci. 1993 Jul; 18(7):247-8. PMID: 8212131.
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      378. Reizer J, Reizer A, Bairoch A, Saier M. A diverse transketolase family that includes the RecP protein of Streptococcus pneumoniae, a protein implicated in genetic recombination. Res Microbiol. 1993 Jun; 144(5):341-7. PMID: 8248627.
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      379. Tam R, Saier M. Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Microbiol Rev. 1993 Jun; 57(2):320-46. PMID: 8336670.
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      380. Mitchell WJ, Reizer J, Herring C, Hoischen C, Saier M. Identification of a phosphoenolpyruvate:fructose phosphotransferase system (fructose-1-phosphate forming) in Listeria monocytogenes. J Bacteriol. 1993 May; 175(9):2758-61. PMID: 8478337.
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      381. Reizer J, Hoischen C, Reizer A, Pham TN, Saier M. Sequence analyses and evolutionary relationships among the energy-coupling proteins Enzyme I and HPr of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Protein Sci. 1993 Apr; 2(4):506-21. PMID: 7686067.
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      382. Tam R, Saier M. A bacterial periplasmic receptor homologue with catalytic activity: cyclohexadienyl dehydratase of Pseudomonas aeruginosa is homologous to receptors specific for polar amino acids. Res Microbiol. 1993 Mar-Apr; 144(3):165-9. PMID: 8210673.
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      383. Chen Y, Reizer J, Saier M, Fairbrother WJ, Wright PE. Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, HPr and IIAglc. Biochemistry. 1993 Jan 12; 32(1):32-7. PMID: 8418852.
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      384. Marger MD, Saier M. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem Sci. 1993 Jan; 18(1):13-20. PMID: 8438231.
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      385. Reizer J, Reizer A, Saier M. The MIP family of integral membrane channel proteins: sequence comparisons, evolutionary relationships, reconstructed pathway of evolution, and proposed functional differentiation of the two repeated halves of the proteins. Crit Rev Biochem Mol Biol. 1993; 28(3):235-57. PMID: 8325040.
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      386. Saier M. Regulatory interactions involving the proteins of the phosphotransferase system in enteric bacteria. J Cell Biochem. 1993 Jan; 51(1):62-8. PMID: 8432744.
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      387. Saier M. Introduction: protein phosphorylation and signal transduction in bacteria. J Cell Biochem. 1993 Jan; 51(1):1-6. PMID: 8381788.
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      388. Kuan J, Saier M. The mitochondrial carrier family of transport proteins: structural, functional, and evolutionary relationships. Crit Rev Biochem Mol Biol. 1993; 28(3):209-33. PMID: 8325039.
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      389. Yamada M, Asaoka S, Saier M, Yamada Y. Characterization of the gcd gene from Escherichia coli K-12 W3110 and regulation of its expression. J Bacteriol. 1993 Jan; 175(2):568-71. PMID: 8419307.
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      390. Reizer J, Finley K, Kakuda D, MacLeod CL, Reizer A, Saier M. Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria. Protein Sci. 1993 Jan; 2(1):20-30. PMID: 8382989.
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      391. Werner PK, Saier M, Müller M. Membrane insertion of the mannitol permease of Escherichia coli occurs under conditions of impaired SecA function. J Biol Chem. 1992 Dec 5; 267(34):24523-32. PMID: 1447197.
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      392. Trandinh CC, Pao GM, Saier M. Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl-prolyl cis-trans isomerases. FASEB J. 1992 Dec; 6(15):3410-20. PMID: 1464374.
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      393. Nikaido H, Saier M. Transport proteins in bacteria: common themes in their design. Science. 1992 Nov 6; 258(5084):936-42. PMID: 1279804.
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      394. Reizer J, Reizer A, Saier M. A new subfamily of bacterial ABC-type transport systems catalyzing export of drugs and carbohydrates. Protein Sci. 1992 Oct; 1(10):1326-32. PMID: 1303751.
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      395. Wittekind M, Rajagopal P, Branchini BR, Reizer J, Saier M, Klevit RE. Solution structure of the phosphocarrier protein HPr from Bacillus subtilis by two-dimensional NMR spectroscopy. Protein Sci. 1992 Oct; 1(10):1363-76. PMID: 1303754.
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      396. Reizer J, Reizer A, Saier M. The putative Na+/H+ antiporter (NapA) of Enterococcus hirae is homologous to the putative K+/H+ antiporter (KefC) of Escherichia coli. FEMS Microbiol Lett. 1992 Jul 1; 73(1-2):161-3. PMID: 1325937.
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      397. Parr TR, Saier M. The bacterial phosphotransferase system as a potential vehicle for the entry of novel antibiotics. Res Microbiol. 1992 Jun; 143(5):443-7. PMID: 1448620.
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      398. Reizer J, Reizer A, Saier M, Jacobson GR. A proposed link between nitrogen and carbon metabolism involving protein phosphorylation in bacteria. Protein Sci. 1992 Jun; 1(6):722-6. PMID: 1304914.
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      399. Stone MJ, Fairbrother WJ, Palmer AG, Reizer J, Saier M, Wright PE. Backbone dynamics of the Bacillus subtilis glucose permease IIA domain determined from 15N NMR relaxation measurements. Biochemistry. 1992 May 12; 31(18):4394-406. PMID: 1316146.
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      400. Fairbrother WJ, Palmer AG, Rance M, Reizer J, Saier M, Wright PE. Assignment of the aliphatic 1H and 13C resonances of the Bacillus subtilis glucose permease IIA domain using double- and triple-resonance heteronuclear three-dimensional NMR spectroscopy. Biochemistry. 1992 May 12; 31(18):4413-25. PMID: 1581296.
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      401. Reizer J, Sutrina SL, Wu LF, Deutscher J, Reddy P, Saier M. Functional interactions between proteins of the phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and Escherichia coli. J Biol Chem. 1992 May 5; 267(13):9158-69. PMID: 1577753.
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      402. Groisman EA, Saier M, Ochman H. Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome. EMBO J. 1992 Apr; 11(4):1309-16. PMID: 1339343.
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      403. Herzberg O, Reddy P, Sutrina S, Saier M, Reizer J, Kapadia G. Structure of the histidine-containing phosphocarrier protein HPr from Bacillus subtilis at 2.0-A resolution. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2499-503. PMID: 1549615.
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      404. Anderson JW, Waygood EB, Saier M, Reizer J. Properties of phosphorylated protein intermediates of the bacterial phosphoenolpyruvate:sugar phosphotransferase system. Biochem Cell Biol. 1992 Mar-Apr; 70(3-4):242-6. PMID: 1515124.
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      405. Saier M, Reizer J. Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. J Bacteriol. 1992 Mar; 174(5):1433-8. PMID: 1537788.
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      406. Reizer J, Saier M, Reizer A. Possible problems with the protein sequence comparison program FASTA. Trends Biochem Sci. 1992 Feb; 17(2):60. PMID: 1566329.
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      407. Fairbrother WJ, Gippert GP, Reizer J, Saier M, Wright PE. Low resolution solution structure of the Bacillus subtilis glucose permease IIA domain derived from heteronuclear three-dimensional NMR spectroscopy. FEBS Lett. 1992 Jan 20; 296(2):148-52. PMID: 1733770.
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      408. Romo AJ, Ruby EG, Saier M. Effect of Bdellovibrio bacteriovorus infection on the phosphoenolpyruvate:sugar phosphotransferase system in Escherichia coli: evidence for activation of cytoplasmic proteolysis. Res Microbiol. 1992 Jan; 143(1):5-14. PMID: 1322553.
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      409. Celikel R, Dai XP, Stewart GC, Sutrina SL, Saier M, Xuong NH, Reizer J. Crystallization and preliminary X-ray analysis of the lactose-specific phosphocarrier protein IIAlac of the phosphoenolpyruvate: sugar phosphotransferase system from Staphylococcus aureus. J Mol Biol. 1991 Dec 20; 222(4):857-9. PMID: 1762152.
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      410. Saier M. A multiplicity of potential carbon catabolite repression mechanisms in prokaryotic and eukaryotic microorganisms. New Biol. 1991 Dec; 3(12):1137-47. PMID: 1667478.
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      411. Vartak NB, Reizer J, Reizer A, Gripp JT, Groisman EA, Wu LF, Tomich JM, Saier M. Sequence and evolution of the FruR protein of Salmonella typhimurium: a pleiotropic transcriptional regulatory protein possessing both activator and repressor functions which is homologous to the periplasmic ribose-binding protein. Res Microbiol. 1991 Nov-Dec; 142(9):951-63. PMID: 1805309.
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      412. Wu LF, Saier M. Differences in codon usage among genes encoding proteins of different function in Rhodobacter capsulatus. Res Microbiol. 1991 Nov-Dec; 142(9):943-9. PMID: 1805308.
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      413. Kapadia G, Chen CC, Reddy P, Saier M, Reizer J, Herzberg O. Crystallization of the IIA domain of the glucose permease of Bacillus subtilis. J Mol Biol. 1991 Oct 20; 221(4):1079-80. PMID: 1942043.
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      414. Liao DI, Kapadia G, Reddy P, Saier M, Reizer J, Herzberg O. Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2-A resolution. Biochemistry. 1991 Oct 8; 30(40):9583-94. PMID: 1911744.
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      415. Yamada Y, Chang YY, Daniels GA, Wu LF, Tomich JM, Yamada M, Saier M. Insertion of the mannitol permease into the membrane of Escherichia coli. Possible involvement of an N-terminal amphiphilic sequence. J Biol Chem. 1991 Sep 25; 266(27):17863-71. PMID: 1917927.
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      416. Reizer A, Pao GM, Saier M. Evolutionary relationships among the permease proteins of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Construction of phylogenetic trees and possible relatedness to proteins of eukaryotic mitochondria. J Mol Evol. 1991 Aug; 33(2):179-93. PMID: 1920454.
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      417. Fairbrother WJ, Cavanagh J, Dyson HJ, Palmer AG, Sutrina SL, Reizer J, Saier M, Wright PE. Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy. Biochemistry. 1991 Jul 16; 30(28):6896-907. PMID: 1906345.
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      418. Reizer A, Deutscher J, Saier M, Reizer J. Analysis of the gluconate (gnt) operon of Bacillus subtilis. Mol Microbiol. 1991 May; 5(5):1081-9. PMID: 1659648.
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      419. Wu LF, Reizer A, Reizer J, Cai B, Tomich JM, Saier M. Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli. J Bacteriol. 1991 May; 173(10):3117-27. PMID: 1850730.
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      420. Pao GM, Wu LF, Johnson KD, Höfte H, Chrispeels MJ, Sweet G, Sandal NN, Saier M. Evolution of the MIP family of integral membrane transport proteins. Mol Microbiol. 1991 Jan; 5(1):33-7. PMID: 2014003.
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      421. Dean DA, Reizer J, Nikaido H, Saier M. Regulation of the maltose transport system of Escherichia coli by the glucose-specific enzyme III of the phosphoenolpyruvate-sugar phosphotransferase system. Characterization of inducer exclusion-resistant mutants and reconstitution of inducer exclusion in proteoliposomes. J Biol Chem. 1990 Dec 5; 265(34):21005-10. PMID: 2250006.
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      422. Romano AH, Saier M, Harriott OT, Reizer J. Physiological studies on regulation of glycerol utilization by the phosphoenolpyruvate:sugar phosphotransferase system in Enterococcus faecalis. J Bacteriol. 1990 Dec; 172(12):6741-8. PMID: 2123855.
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      423. Wu LF, Saier M. Nucleotide sequence of the fruA gene, encoding the fructose permease of the Rhodobacter capsulatus phosphotransferase system, and analyses of the deduced protein sequence. J Bacteriol. 1990 Dec; 172(12):7167-78. PMID: 2254279.
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      424. Reizer J, Reizer A, Saier M. The Na+/pantothenate symporter (PanF) of Escherichia coli is homologous to the Na+/proline symporter (PutP) of E. coli and the Na+/glucose symporters of mammals. Res Microbiol. 1990 Nov-Dec; 141(9):1069-72. PMID: 1965458.
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      425. Jiang W, Wu LF, Tomich J, Saier M, Niehaus WG. Corrected sequence of the mannitol (mtl) operon in Escherichia coli. Mol Microbiol. 1990 Nov; 4(11):2003-6. PMID: 1964486.
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      426. Saier M, Reizer J. Domain shuffling during evolution of the proteins of the bacterial phosphotransferase system. Res Microbiol. 1990 Nov-Dec; 141(9):1033-8. PMID: 2092356.
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      427. Reizer J, Reizer A, Saier M. The cellobiose permease of Escherichia coli consists of three proteins and is homologous to the lactose permease of Staphylococcus aureus. Res Microbiol. 1990 Nov-Dec; 141(9):1061-7. PMID: 2092358.
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      428. Sutrina SL, Reddy P, Saier M, Reizer J. The glucose permease of Bacillus subtilis is a single polypeptide chain that functions to energize the sucrose permease. J Biol Chem. 1990 Oct 25; 265(30):18581-9. PMID: 2120236.
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      429. Saier M, Wu LF, Reizer J. Regulation of bacterial physiological processes by three types of protein phosphorylating systems. Trends Biochem Sci. 1990 Oct; 15(10):391-5. PMID: 2251731.
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      430. Feldheim DA, Chin AM, Nierva CT, Feucht BU, Cao YW, Xu YF, Sutrina SL, Saier M. Physiological consequences of the complete loss of phosphoryl-transfer proteins HPr and FPr of the phosphoenolpyruvate:sugar phosphotransferase system and analysis of fructose (fru) operon expression in Salmonella typhimurium. J Bacteriol. 1990 Sep; 172(9):5459-69. PMID: 2203752.
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      431. Schnetz K, Sutrina SL, Saier M, Rak B. Identification of catalytic residues in the beta-glucoside permease of Escherichia coli by site-specific mutagenesis and demonstration of interdomain cross-reactivity between the beta-glucoside and glucose systems. J Biol Chem. 1990 Aug 15; 265(23):13464-71. PMID: 2199437.
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      432. Saier M, Wu LF, Baker ME, Sweet G, Reizer A, Reizer J. Evolution of permease diversity and energy-coupling mechanisms with special reference to the bacterial phosphotransferase system. Biochim Biophys Acta. 1990 Jul 25; 1018(2-3):248-51. PMID: 2168212.
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      433. Wu LF, Saier M. On the evolutionary origins of the bacterial phosphoenolpyruvate:sugar phosphotransferase system. Mol Microbiol. 1990 Jul; 4(7):1219-22. PMID: 2172696.
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      434. Wu LF, Tomich JM, Saier M. Structure and evolution of a multidomain multiphosphoryl transfer protein. Nucleotide sequence of the fruB(HI) gene in Rhodobacter capsulatus and comparisons with homologous genes from other organisms. J Mol Biol. 1990 Jun 20; 213(4):687-703. PMID: 2193161.
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      435. Kapadia G, Reizer J, Sutrina SL, Saier M, Reddy P, Herzberg O. Crystallization of the Bacillus subtilis histidine-containing phosphocarrier protein HPr and of some of its site-directed mutants. J Mol Biol. 1990 Mar 5; 212(1):1-2. PMID: 2108249.
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      436. Saier M. Evolution of permease diversity and energy-coupling mechanisms: an introduction. Res Microbiol. 1990 Mar-Apr; 141(3):281-6. PMID: 2281190.
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      437. Sutrina SL, Schnetz K, Rak B, Saier M. Mechanism of sugar transport and phosphorylation via permeases of the bacterial phosphotransferase system: catalytic residues in the beta-glucoside-specific permease as defined by site-specific mutagenesis. Res Microbiol. 1990 Mar-Apr; 141(3):368-74. PMID: 2281195.
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      438. Baker ME, Saier M. A common ancestor for bovine lens fiber major intrinsic protein, soybean nodulin-26 protein, and E. coli glycerol facilitator. Cell. 1990 Jan 26; 60(2):185-6. PMID: 2404610.
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      439. Yamada M, Yamada Y, Saier M. Nucleotide sequence and expression of the gutQ gene within the glucitol operon of Escherichia coli. DNA Seq. 1990; 1(2):141-5. PMID: 2134185.
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      440. Groisman EA, Saier M. Salmonella virulence: new clues to intramacrophage survival. Trends Biochem Sci. 1990 Jan; 15(1):30-3. PMID: 2180148.
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      441. Wittekind M, Reizer J, Deutscher J, Saier M, Klevit RE. Common structural changes accompany the functional inactivation of HPr by seryl phosphorylation or by serine to aspartate substitution. Biochemistry. 1989 Dec 26; 28(26):9908-12. PMID: 2515891.
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      442. Saier M, Werner PK, Müller M. Insertion of proteins into bacterial membranes: mechanism, characteristics, and comparisons with the eucaryotic process. Microbiol Rev. 1989 Sep; 53(3):333-66. PMID: 2677637.
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      443. Reizer J, Deutscher J, Saier M. Metabolite-sensitive, ATP-dependent, protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system in gram-positive bacteria. Biochimie. 1989 Sep-Oct; 71(9-10):989-96. PMID: 2557095.
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      444. Saier M. Involvement of the bacterial phosphotransferase system in diverse mechanisms of transcriptional regulation. Res Microbiol. 1989 Jul-Aug; 140(6):349-52. PMID: 2616889.
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      445. Reizer J, Sutrina SL, Saier M, Stewart GC, Peterkofsky A, Reddy P. Mechanistic and physiological consequences of HPr(ser) phosphorylation on the activities of the phosphoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: studies with site-specific mutants of HPr. EMBO J. 1989 Jul; 8(7):2111-20. PMID: 2507315.
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      446. Saier M. Current studies on the bacterial phosphotransferase system in the Saier laboratory (La Jolla, California, summer, 1988). FEMS Microbiol Rev. 1989 Jun; 5(1-2):183-92. PMID: 2699248.
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      447. Chin AM, Feldheim DA, Saier M. Altered transcriptional patterns affecting several metabolic pathways in strains of Salmonella typhimurium which overexpress the fructose regulon. J Bacteriol. 1989 May; 171(5):2424-34. PMID: 2496106.
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      448. Saier M. Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Microbiol Rev. 1989 Mar; 53(1):109-20. PMID: 2651862.
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      449. Tamm LK, Tomich JM, Saier M. Membrane incorporation and induction of secondary structure of synthetic peptides corresponding to the N-terminal signal sequences of the glucitol and mannitol permeases of Escherichia coli. J Biol Chem. 1989 Feb 15; 264(5):2587-92. PMID: 2644265.
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      450. Schnierow BJ, Yamada M, Saier M. Partial nucleotide sequence of the pts operon in Salmonella typhimurium: comparative analyses in five bacterial genera. Mol Microbiol. 1989 Jan; 3(1):113-8. PMID: 2497295.
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      451. Saier M, Yamada M, Suda K, Erni B, Rak B, Lengeler J, Stewart GC, Waygood EB, Rapoport G. Bacterial proteins with N-terminal leader sequences resembling mitochondrial targeting sequences of eukaryotes. Biochimie. 1988 Dec; 70(12):1743-8. PMID: 3150678.
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      452. Yamada M, Saier M. Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli. J Mol Biol. 1988 Oct 5; 203(3):569-83. PMID: 3062173.
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      453. Boerner P, Saier M. Effects of 5-azacytidine, sodium butyrate, and phorbol esters on amino acid transport system A in a kidney epithelial cell line, MDCK: evidence for multiple mechanisms of regulation. J Cell Physiol. 1988 Oct; 137(1):117-24. PMID: 2459137.
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      454. Saier M, Deutscher J. [Coordinate control of cell growth and transport functions in a kidney cell line]. Naturwissenschaften. 1988 Sep; 75(9):451-7. PMID: 3226436.
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      455. Saier M, Daniels GA, Boerner P, Lin J. Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth. J Membr Biol. 1988 Aug; 104(1):1-20. PMID: 3054116.
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      456. Davis T, Yamada M, Elgort M, Saier M. Nucleotide sequence of the mannitol (mtl) operon in Escherichia coli. Mol Microbiol. 1988 May; 2(3):405-12. PMID: 3135464.
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      457. Saier M, McCaldon P. Statistical and functional analyses of viral and cellular proteins with N-terminal amphipathic alpha-helices with large hydrophobic moments: importance to macromolecular recognition and organelle targeting. J Bacteriol. 1988 May; 170(5):2296-300. PMID: 3360744.
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      458. Sutrina SL, Chin AM, Esch F, Saier M. Purification and characterization of the fructose-inducible HPr-like protein, FPr, and the fructose-specific enzyme III of the phosphoenolpyruvate: sugar phosphotransferase system of Salmonella typhimurium. J Biol Chem. 1988 Apr 15; 263(11):5061-9. PMID: 3281935.
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      459. Daniels GA, Drews G, Saier M. Properties of a Tn5 insertion mutant defective in the structural gene (fruA) of the fructose-specific phosphotransferase system of Rhodobacter capsulatus and cloning of the fru regulon. J Bacteriol. 1988 Apr; 170(4):1698-703. PMID: 2832374.
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      460. Sutrina SL, Reizer J, Saier M. Inducer expulsion in Streptococcus pyogenes: properties and mechanism of the efflux reaction. J Bacteriol. 1988 Apr; 170(4):1874-7. PMID: 3280553.
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      461. Saier M, Yamada M, Erni B, Suda K, Lengeler J, Ebner R, Argos P, Rak B, Schnetz K, Lee CA. Sugar permeases of the bacterial phosphoenolpyruvate-dependent phosphotransferase system: sequence comparisons. FASEB J. 1988 Mar 1; 2(3):199-208. PMID: 2832233.
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      462. Manayan R, Tenn G, Yee HB, Desai JD, Yamada M, Saier M. Genetic analyses of the mannitol permease of Escherichia coli: isolation and characterization of a transport-deficient mutant which retains phosphorylation activity. J Bacteriol. 1988 Mar; 170(3):1290-6. PMID: 3277953.
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      463. Reizer J, Saier M, Deutscher J, Grenier F, Thompson J, Hengstenberg W. The phosphoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: properties, mechanism, and regulation. Crit Rev Microbiol. 1988; 15(4):297-338. PMID: 3060316.
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      464. Yamada M, Feucht BU, Saier M. Regulation of gluconeogenesis by the glucitol enzyme III of the phosphotransferase system in Escherichia coli. J Bacteriol. 1987 Dec; 169(12):5416-22. PMID: 2824435.
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      465. Yamada M, Saier M. Physical and genetic characterization of the glucitol operon in Escherichia coli. J Bacteriol. 1987 Jul; 169(7):2990-4. PMID: 3036766.
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      466. Lauf PK, McManus TJ, Haas M, Forbush B, Duhm J, Flatman PW, Saier M, Russell JM. Physiology and biophysics of chloride and cation cotransport across cell membranes. Fed Proc. 1987 May 15; 46(7):2377-94. PMID: 3552736.
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      467. Yamada M, Saier M. Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon. J Biol Chem. 1987 Apr 25; 262(12):5455-63. PMID: 3553176.
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      468. Sutrina SL, Waygood EB, Grenier FC, Saier M. HPr/HPr-P phosphoryl exchange reaction catalyzed by the mannitol specific enzyme II of the bacterial phosphotransferase system. J Biol Chem. 1987 Feb 25; 262(6):2636-41. PMID: 3102473.
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      469. Chin AM, Feucht BU, Saier M. Evidence for regulation of gluconeogenesis by the fructose phosphotransferase system in Salmonella typhimurium. J Bacteriol. 1987 Feb; 169(2):897-9. PMID: 3542978.
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      470. Chin AM, Sutrina S, Feldheim DA, Saier M. Genetic expression of enzyme I activity of the phosphoenolpyruvate:sugar phosphotransferase system in ptsHI deletion strains of Salmonella typhimurium. J Bacteriol. 1987 Feb; 169(2):894-6. PMID: 3542977.
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      471. Reizer J, Saier M. Mechanism and regulation of phosphate transport in Streptococcus pyogenes. J Bacteriol. 1987 Jan; 169(1):297-302. PMID: 3539921.
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      472. Boerner P, Evans-Laying M, U HS, Saier M. Polarity of neutral amino acid transport and characterization of a broad specificity transport activity in a kidney epithelial cell line, MDCK. J Biol Chem. 1986 Oct 25; 261(30):13957-62. PMID: 3771512.
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      473. Saier M, Boerner P, Grenier FC, McRoberts JA, Rindler MJ, Taub M, U HS. Sodium entry pathways in renal epithelial cell lines. Miner Electrolyte Metab. 1986; 12(1):42-50. PMID: 2421147.
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      474. Grenier FC, Waygood EB, Saier M. The bacterial phosphotransferase system: kinetic characterization of the glucose, mannitol, glucitol, and N-acetylglucosamine systems. J Cell Biochem. 1986; 31(2):97-105. PMID: 3015992.
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      475. Grenier FC, Waygood EB, Saier M. Bacterial phosphotransferase system: regulation of the glucose and mannose enzymes II by sulfhydryl oxidation. Biochemistry. 1985 Aug 27; 24(18):4872-6. PMID: 3907693.
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      476. Grenier FC, Reizer J, Waygood EB, Saier M. Evidence for covalently cross-linked dimers and trimers of enzyme I of the Escherichia coli phosphotransferase system. J Bacteriol. 1985 Jul; 163(1):243-7. PMID: 3891729.
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      477. Novotny MJ, Frederickson WL, Waygood EB, Saier M. Allosteric regulation of glycerol kinase by enzyme IIIglc of the phosphotransferase system in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1985 May; 162(2):810-6. PMID: 2985549.
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      478. Grenier FC, Hayward I, Novotny MJ, Leonard JE, Saier M. Identification of the phosphocarrier protein enzyme IIIgut: essential component of the glucitol phosphotransferase system in Salmonella typhimurium. J Bacteriol. 1985 Mar; 161(3):1017-22. PMID: 3882659.
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      479. U HS, Boerner P, Rindler MJ, Chuman L, Saier M. Characterization of chemically and virally transformed variants of Madin-Darby canine kidney (MDCK) epithelial cells. J Cell Physiol. 1985 Feb; 122(2):299-307. PMID: 2981894.
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      480. Boerner P, Saier M. Adaptive regulatory control of System A transport activity in a kidney epithelial cell line (MDCK) and in a transformed variant (MDCK-T1). J Cell Physiol. 1985 Feb; 122(2):308-15. PMID: 3968188.
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      481. Boerner P, Saier M. Hormonal regulation of the System A amino acid transport adaptive response mechanism in a kidney epithelial cell line (MDCK). J Cell Physiol. 1985 Feb; 122(2):316-22. PMID: 3881463.
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      482. Grenier FC, Waygood EB, Saier M. Bacterial phosphotransferase system: regulation of mannitol enzyme II activity by sulfhydryl oxidation. Biochemistry. 1985 Jan 1; 24(1):47-51. PMID: 3888258.
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      483. Saier M, Grenier FC, Lee CA, Waygood EB. Evidence for the evolutionary relatedness of the proteins of the bacterial phosphoenolpyruvate:sugar phosphotransferase system. J Cell Biochem. 1985; 27(1):43-56. PMID: 3884637.
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      484. Reizer J, Novotny MJ, Hengstenberg W, Saier M. Properties of ATP-dependent protein kinase from Streptococcus pyogenes that phosphorylates a seryl residue in HPr, a phosphocarrier protein of the phosphotransferase system. J Bacteriol. 1984 Oct; 160(1):333-40. PMID: 6434522.
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      485. Novotny MJ, Reizer J, Esch F, Saier M. Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli. J Bacteriol. 1984 Sep; 159(3):986-90. PMID: 6384188.
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      486. Reizer J, Novotny MJ, Stuiver I, Saier M. Regulation of glycerol uptake by the phosphoenolpyruvate-sugar phosphotransferase system in Bacillus subtilis. J Bacteriol. 1984 Jul; 159(1):243-50. PMID: 6429122.
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      487. Sarno MV, Tenn LG, Desai A, Chin AM, Grenier FC, Saier M. Genetic evidence for glucitol-specific enzyme III, an essential phosphocarrier protein of the Salmonella typhimurium glucitol phosphotransferase system. J Bacteriol. 1984 Mar; 157(3):953-5. PMID: 6365895.
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      488. Saier M, Boyden DA. Mechanism, regulation and physiological significance of the loop diuretic-sensitive NaCl/KCl symport system in animal cells. Mol Cell Biochem. 1984; 59(1-2):11-32. PMID: 6323961.
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      489. Deutscher J, Saier M. ATP-dependent protein kinase-catalyzed phosphorylation of a seryl residue in HPr, a phosphate carrier protein of the phosphotransferase system in Streptococcus pyogenes. Proc Natl Acad Sci U S A. 1983 Nov; 80(22):6790-4. PMID: 6359157.
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      490. McRoberts JA, Tran CT, Saier M. Characterization of low potassium-resistant mutants of the Madin-Darby canine kidney cell line with defects in NaCl/KCl symport. J Biol Chem. 1983 Oct 25; 258(20):12320-6. PMID: 6630190.
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      491. Reizer J, Saier M. Involvement of lactose enzyme II of the phosphotransferase system in rapid expulsion of free galactosides from Streptococcus pyogenes. J Bacteriol. 1983 Oct; 156(1):236-42. PMID: 6413489.
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      492. Reizer J, Novotny MJ, Panos C, Saier M. Mechanism of inducer expulsion in Streptococcus pyogenes: a two-step process activated by ATP. J Bacteriol. 1983 Oct; 156(1):354-61. PMID: 6225770.
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      493. Lee CA, Saier M. Mannitol-specific enzyme II of the bacterial phosphotransferase system. III. The nucleotide sequence of the permease gene. J Biol Chem. 1983 Sep 10; 258(17):10761-7. PMID: 6309813.
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      494. Jacobson GR, Lee CA, Leonard JE, Saier M. Mannitol-specific enzyme II of the bacterial phosphotransferase system. I. Properties of the purified permease. J Biol Chem. 1983 Sep 10; 258(17):10748-56. PMID: 6350293.
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      495. Leonard JE, Saier M. Mannitol-specific enzyme II of the bacterial phosphotransferase system. II. Reconstitution of vectorial transphosphorylation in phospholipid vesicles. J Biol Chem. 1983 Sep 10; 258(17):10757-60. PMID: 6350294.
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      496. Saier M, Novotny MJ, Comeau-Fuhrman D, Osumi T, Desai JD. Cooperative binding of the sugar substrates and allosteric regulatory protein (enzyme IIIGlc of the phosphotransferase system) to the lactose and melibiose permeases in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1983 Sep; 155(3):1351-7. PMID: 6350268.
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      497. Lee CA, Saier M. Use of cloned mtl genes of Escherichia coli to introduce mtl deletion mutations into the chromosome. J Bacteriol. 1983 Feb; 153(2):685-92. PMID: 6401703.
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      498. Taub M, Saier M, Chuman L, Hiller S. Loss of the PGE1 requirement for MDCK cell growth associated with a defect in cyclic AMP phosphodiesterase. J Cell Physiol. 1983 Feb; 114(2):153-61. PMID: 6185509.
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      499. Boerner P, Saier M. Growth regulation and amino acid transport in epithelial cells: influence of culture conditions and transformation on A, ASC, and L transport activities. J Cell Physiol. 1982 Nov; 113(2):240-6. PMID: 6757258.
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      500. Chuman L, Fine LG, Cohen AH, Saier M. Continuous growth of proximal tubular kidney epithelial cells in hormone-supplemented serum-free medium. J Cell Biol. 1982 Sep; 94(3):506-10. PMID: 6182146.
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      501. Saier M, Keeler DK, Feucht BU. Physiological desensitization of carbohydrate permeases and adenylate cyclase to regulation by the phosphoenolpyruvate:sugar phosphotransferase system in Escherichia coli and Salmonella typhimurium. Involvement of adenosine cyclic 3',5'-phosphate and inducer. J Biol Chem. 1982 Mar 10; 257(5):2509-17. PMID: 6277902.
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      502. McRoberts JA, Erlinger S, Rindler MJ, Saier M. Furosemide-sensitive salt transport in the Madin-Darby canine kidney cell line. Evidence for the cotransport of Na+, K+, and Cl-. J Biol Chem. 1982 Mar 10; 257(5):2260-6. PMID: 6277890.
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      503. Rindler MJ, McRoberts JA, Saier M. (Na+,K+)-cotransport in the Madin-Darby canine kidney cell line. Kinetic characterization of the interaction between Na+ and K+. J Biol Chem. 1982 Mar 10; 257(5):2254-9. PMID: 6277889.
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      504. Osumi T, Saier M. Mechanism of regulation of the lactose permease by the phosphotransferase system in Escherichia coli: evidence for protein-protein interaction. Ann Microbiol (Paris). 1982 Mar-Apr; 133(2):269-73. PMID: 7044217.
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      505. Erlinger SU, Saier M. Decrease in protein content and cell volume of cultured dog kidney epithelial cells during growth. In Vitro. 1982 Mar; 18(3 Pt 1):196-202. PMID: 7129474.
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      506. Osumi T, Saier M. Regulation of lactose permease activity by the phosphoenolpyruvate:sugar phosphotransferase system: evidence for direct binding of the glucose-specific enzyme III to the lactose permease. Proc Natl Acad Sci U S A. 1982 Mar; 79(5):1457-61. PMID: 7041121.
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      507. Saier M, Cox DF, Feucht BU, Novotny MJ. Evidence for the functional association of enzyme I and HPr of the phosphoenolpyruvate-sugar phosphotransferase system with the membrane in sealed vesicles of Escherichia coli. J Cell Biochem. 1982; 18(2):231-8. PMID: 7040430.
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      508. Saier M, Erlinger S, Boerner P. Studies on growth regulation and the mechanism of transformation of the kidney epithelial cell line, MDCK: importance of transport function to growth. Prog Clin Biol Res. 1982; 91:569-97. PMID: 7146013.
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      509. Dills SS, Schmidt MR, Saier M. Regulation of lactose transport by the phosphoenolpyruvate-sugar phosphotransferase system in membrane vesicles of Escherichia coli. J Cell Biochem. 1982; 18(2):239-44. PMID: 7040431.
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      510. Lee CA, Jacobson GR, Saier M. Plasmid-directed synthesis of enzymes required for D-mannitol transport and utilization in Escherichia coli. Proc Natl Acad Sci U S A. 1981 Dec; 78(12):7336-40. PMID: 6801648.
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      511. Rindler MJ, Saier M. Evidence for Na+/H+ antiport in cultured dog kidney cells (MDCK). J Biol Chem. 1981 Nov 10; 256(21):10820-5. PMID: 7287736.
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      512. Dills SS, Lee CA, Saier M. Phosphoenolpyruvate-dependent sugar phosphotransferase activity in Megasphaera elsdenii. Can J Microbiol. 1981 Sep; 27(9):949-52. PMID: 7306882.
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      513. Thompson J, Saier M. Regulation of methyl-beta-d-thiogalactopyranoside-6-phosphate accumulation in Streptococcus lactis by exclusion and expulsion mechanisms. J Bacteriol. 1981 Jun; 146(3):885-94. PMID: 6787017.
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      514. Saier M. Growth and differentiated properties of a kidney epithelial cell line (MDCK). Am J Physiol. 1981 Mar; 240(3):C106-9. PMID: 6259947.
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      515. Leonard JE, Saier M. Genetic dissection of catalytic activities of the Salmonella typhimurium mannitol enzyme II. J Bacteriol. 1981 Feb; 145(2):1106-9. PMID: 6257647.
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      516. Taub M, Saier M. Amiloride-resistant Madin-Darby canine kidney (MDCK) cells exhibit decreased cation transport. J Cell Physiol. 1981 Feb; 106(2):191-9. PMID: 6260818.
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      517. Saier M, Schmidt MR. Vectorial and nonvectorial transphosphorylation catalyzed by enzymes II of the bacterial phosphotransferase system. J Bacteriol. 1981 Jan; 145(1):391-7. PMID: 6780516.
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      518. Taub M, U B, Chuman L, Rindler MJ, Saier M, Sato G. Alterations in growth requirements of kidney epithelial cells in defined medium associated with malignant transformation. J Supramol Struct Cell Biochem. 1981; 15(1):63-72. PMID: 6265706.
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      519. Rephaeli AW, Saier M. Substrate specificity and kinetic characterization of sugar uptake and phosphorylation, catalyzed by the mannose enzyme II of the phosphotransferase system in Salmonella typhimurium. J Biol Chem. 1980 Sep 25; 255(18):8585-91. PMID: 6997301.
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      520. Saier M, Schmidt MR, Lin P. Phosphoryl exchange reaction catalyzed by enzyme I of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Kinetic characterization. J Biol Chem. 1980 Sep 25; 255(18):8579-84. PMID: 6997300.
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      521. Dills SS, Apperson A, Schmidt MR, Saier M. Carbohydrate transport in bacteria. Microbiol Rev. 1980 Sep; 44(3):385-418. PMID: 6999324.
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      522. Sang UH, Saier M, Ellisman MH. Tight junction formation in the establishment of intramembranous particle polarity in aggregating MDCK cells. Effect of drug treatment. Exp Cell Res. 1980 Jul; 128(1):223-35. PMID: 7408983.
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      523. Rephaeli AW, Artenstein IR, Saier M. Physiological function of periplasmic hexose phosphatase in Salmonella typhimurium. J Bacteriol. 1980 Mar; 141(3):1474-7. PMID: 6245072.
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      524. Rephaeli AW, Saier M. Regulation of genes coding for enzyme constituents of the bacterial phosphotransferase system. J Bacteriol. 1980 Feb; 141(2):658-63. PMID: 6245053.
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      525. Saier M, Feucht BU. Regulation of carbohydrate transport activities in Salmonella typhimurium: use of the phosphoglycerate transport system to energize solute uptake. J Bacteriol. 1980 Feb; 141(2):611-7. PMID: 6988388.
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      526. Feucht BU, Saier M. Fine control of adenylate cyclase by the phosphoenolpyruvate:sugar phosphotransferase systems in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1980 Feb; 141(2):603-10. PMID: 6245052.
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      527. Saier M. Catalytic activities associated with the enzymes II of the bacterial phosphotransferase system. J Supramol Struct. 1980; 14(3):281-94. PMID: 7012451.
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      528. Taub M, Saier M. Regulation of 22Na+ transport by calcium in an established kidney epithelial cell line. J Biol Chem. 1979 Nov 25; 254(22):11440-4. PMID: 387772.
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      529. Rindler MJ, Taub M, Saier M. Uptake of 22Na+ by cultured dog kidney cells (MDCK). J Biol Chem. 1979 Nov 25; 254(22):11431-9. PMID: 500650.
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      530. Hoi Sang U, Saier M, Ellisman MH. Tight junction formation is closely linked to the polar redistribution of intramembranous particles in aggregating MDCK epithelia. Exp Cell Res. 1979 Sep; 122(2):384-91. PMID: 116860.
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      531. Taub M, Chuman L, Saier M, Sato G. Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium. Proc Natl Acad Sci U S A. 1979 Jul; 76(7):3338-42. PMID: 291007.
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      532. Rindler MJ, Chuman LM, Shaffer L, Saier M. Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). J Cell Biol. 1979 Jun; 81(3):635-48. PMID: 222773.
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      533. Reid LM, Stiles CD, Saier M, Rindler MJ. Growth of nontumorigenic cells in Millipore diffusion chambers implanted in mice and implications for in vivo growth regulation. Cancer Res. 1979 May; 39(5):1467-73. PMID: 427791.
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      534. Jacobson GR, Lee CA, Saier M. Purification of the mannitol-specific enzyme II of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system. J Biol Chem. 1979 Jan 25; 254(2):249-52. PMID: 368051.
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      535. Taub M, Saier M. An established but differentiated kidney epithelial cell line (MDCK). Methods Enzymol. 1979; 58:552-60. PMID: 218080.
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      536. Rephaeli AW, Saier M. Kinetic analyses of the sugar phosphate:sugar transphosphorylation reaction catalyzed by the glucose enzyme II complex of the bacterial phosphotransferase system. J Biol Chem. 1978 Nov 10; 253(21):7595-7. PMID: 359550.
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      537. Rindler MJ, Bashor MM, Spitzer N, Saier M. Regulation of adenosine 3':5'-monophosphate efflux from animal cells. J Biol Chem. 1978 Aug 10; 253(15):5431-6. PMID: 209041.
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      538. Saier M, Schmidt MR, Leibowitz M. Cyclic AMP-dependent synthesis of fimbriae in Salmonella typhimurium: effects of cya and pts mutations. J Bacteriol. 1978 Apr; 134(1):356-8. PMID: 206537.
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      539. Saier M, Straud H, Massman LS, Judice JJ, Newman MJ, Feucht BU. Permease-specific mutations in Salmonella typhimurium and Escherichia coli that release the glycerol, maltose, melibiose, and lactose transport systems from regulation by the phosphoenolpyruvate:sugar phosphotransferase system. J Bacteriol. 1978 Mar; 133(3):1358-67. PMID: 346569.
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      540. Saier M, Feucht BU, Mora WK. Sugar phosphate: sugar transphosphorylation and exchange group translocation catalyzed by the enzyme 11 complexes of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. J Biol Chem. 1977 Dec 25; 252(24):8899-907. PMID: 336623.
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      541. Saier M, Cox DF, Moczydlowski EG. Sugar phosphate:sugar transphosphorylation coupled to exchange group translocation catalyzed by the enzyme II complexes of the phosphoenolpyruvate:sugar phosphotransferase system in membrane vesicles of Escherichia coli. J Biol Chem. 1977 Dec 25; 252(24):8908-16. PMID: 336624.
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      542. Saier M, Newman MJ, Rephaeli AW. Properties of a phosphoenolpyruvate: mannitol phosphotransferase system in Spirochaeta aurantia. J Biol Chem. 1977 Dec 25; 252(24):8890-8. PMID: 925030.
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      543. Saier M. Bacterial phosphoenolpyruvate: sugar phosphotransferase systems: structural, functional, and evolutionary interrelationships. Bacteriol Rev. 1977 Dec; 41(4):856-71. PMID: 339892.
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      544. Saier M, Staley JT. Phosphoenolpyruvate:sugar phosphotransferase system in Ancalomicrobium adetum. J Bacteriol. 1977 Aug; 131(2):716-8. PMID: 328495.
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      545. Tuttle RC, Saier M. Phosphoprotein phosphatase activity associated with the cytoplasmic membrane of Salmonella typhimurium and Escherichia coli. J Biol Chem. 1977 Jun 25; 252(12):4416-7. PMID: 16933.
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      546. Saier M, Roseman S. Sugar transport. The crr mutation: its effect on repression of enzyme synthesis. J Biol Chem. 1976 Nov 10; 251(21):6598-605. PMID: 789369.
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      547. Saier M, Roseman S. Sugar transport. 2nducer exclusion and regulation of the melibiose, maltose, glycerol, and lactose transport systems by the phosphoenolpyruvate:sugar phosphotransferase system. J Biol Chem. 1976 Nov 10; 251(21):6606-15. PMID: 789370.
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      548. Simoni RD, Roseman S, Saier M. Sugar transport. Properties of mutant bacteria defective in proteins of the phosphoenolpyruvate: sugar phosphotransferase system. J Biol Chem. 1976 Nov 10; 251(21):6584-97. PMID: 789368.
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      549. Castro L, Feucht BU, Morse ML, Saier M. Regulation of carbohydrate permeases and adenylate cyclase in Escherichia coli. Studies with mutant strains in which enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system is thermolabile. J Biol Chem. 1976 Sep 25; 251(18):5522-7. PMID: 184083.
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      550. Stiles CD, Desmond W, Chuman LM, Sato G, Saier M. Relationship of cell growth behavior in vitro to tumorigenicity in athymic nude mice. Cancer Res. 1976 Sep; 36(9 pt.1):3300-5. PMID: 975091.
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      551. Rephaeli AW, Saier M. Effects of crp mutations on adenosine 3',5'-monophosphate metabolism in Salmonella typhimurium. J Bacteriol. 1976 Jul; 127(1):120-7. PMID: 179973.
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      552. Saier M, Newman MJ. Direct transfer of the phosphoryl moiety of mannitol 1-phosphate to [14C]mannitol catalyzed by the enzyme II complexes of the phosphoenolpyruvate: mannitol phosphotransferase systems in Spirochaeta aurantia and Salmonella typhimurium. J Biol Chem. 1976 Jun 25; 251(12):3834-7. PMID: 819432.
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      553. Stiles CD, Desmond W, Chuman LM, Sato G, Saier M. Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse. Cancer Res. 1976 Apr; 36(4):1353-60. PMID: 1260760.
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      554. Saier M, Feucht BU, Hofstadter LJ. Regulation of carbohydrate uptake and adenylate cyclase activity mediated by the enzymes II of the phosphoenolpyruvate: sugar phosphotransferase system in Escherichia coli. J Biol Chem. 1976 Feb 10; 251(3):883-92. PMID: 765335.
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      555. Saier M, Simoni RD. Regulation of carbohydrate uptake in gram-positive bacteria. J Biol Chem. 1976 Feb 10; 251(3):893-4. PMID: 1249061.
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      556. Stiles CD, Roberts PE, Saier M, Sato G. Growth regulation and suppression of metastasis in the congenitally athymic nude mouse. Hamatol Bluttransfus. 1976; 19:185-94. PMID: 188726.
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      557. Stiles CD, Desmond W, Sato G, Saier M. Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice. Proc Natl Acad Sci U S A. 1975 Dec; 72(12):4971-5. PMID: 174085.
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      558. Saier M, Feucht BU, McCaman MT. Regulation of intracellular adenosine cyclic 3':5'-monophosphate levels in Escherichia coli and Salmonella typhimurium. Evidence for energy-dependent excretion of the cyclic nucleotide. J Biol Chem. 1975 Oct 10; 250(19):7593-601. PMID: 170265.
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      559. Saier M, Feucht BU. Coordinate regulation of adenylate cyclase and carbohydrate permeases by the phosphoenolpyruvate:sugar phosphotransferase system in Salmonella typhimurium. J Biol Chem. 1975 Sep 10; 250(17):7078-80. PMID: 169265.
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      560. Varon S, Saier M. Culture techniques and glial-neuronal interrelationships in vitro. Exp Neurol. 1975 Sep; 48(3 pt. 2):135-62. PMID: 241659.
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      561. Saier M, Wentzel DL, Feucht BU, Judice JJ. A transport system for phosphoenolpyruvate, 2-phosphoglycerate, and 3-phosphoglycerate in Salmonella typhimurium. J Biol Chem. 1975 Jul 10; 250(13):5089-96. PMID: 238977.
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      562. Doore BJ, Bashor MM, Spitzer N, Mawe RC, Saier M. Regulation of adenosine 3' :5'-monophosphate efflux from rat glioma cells in culture*. J Biol Chem. 1975 Jun 10; 250(11):4371-2. PMID: 165200.
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      563. Saier M, Bromberg FG, Roseman S. Characterization of constitutive galactose permease mutants in Salmonella typhimurium. J Bacteriol. 1973 Jan; 113(1):512-4. PMID: 4569699.
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      564. Saier M, Roseman S. Inducer exclusion and repression of enzyme synthesis in mutants of Salmonella typhimurium defective in enzyme I of the phosphoenolpyruvate: sugar phosphotransferase system. J Biol Chem. 1972 Feb 10; 247(3):972-5. PMID: 4550766.
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      565. Saier M, Feucht BU, Roseman S. Phosphoenolpyruvate-dependent fructose phosphorylation in photosynthetic bacteria. J Biol Chem. 1971 Dec 25; 246(24):7819-21. PMID: 5002684.
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      566. Saier M, Young WS, Roseman S. Utilization and transport of hexoses by mutant strains of Salmonella typhimurium lacking enzyme I of the phosphoenolpyruvate-dependent phosphotransferase system. J Biol Chem. 1971 Sep 25; 246(18):5838-40. PMID: 4938041.
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      567. Saier M, Simoni RD, Roseman S. The physiological behavior of enzyme I and heat-stable protein mutants of a bacterial phosphotransferase system. J Biol Chem. 1970 Nov 10; 245(21):5870-3. PMID: 4919491.
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      568. Saier M, Ballou CE. The 6-O-methylglucose-containing lipopolysaccharide of Mycobacterium phlei. Structure of the reducing end of the polysaccharide. J Biol Chem. 1968 Aug 25; 243(16):4319-31. PMID: 5679966.
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      569. Saier M, Ballou CE. The 6-O-methylglucose-containig lipopolysaccharide of Mycobacterium phlei. Complet structure of the polysaccharide. J Biol Chem. 1968 Aug 25; 243(16):4332-41. PMID: 5679967.
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      570. Saier M, Ballou CE. The 6-O-methylglucose-containing lipopolysaccharide of Mycobacterium phlei. Identification of D-glyceric acid and 3-O-methyl-D-glucose in the polysaccharide. J Biol Chem. 1968 Mar 10; 243(5):992-1005. PMID: 4295929.
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      571. Saier M, Jenkins WT. Alanine aminotransferase. II. The basis for substrate specificity. J Biol Chem. 1967 Jan 10; 242(1):101-8. PMID: 6016324.
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      572. Saier M, Jenkins WT. Alanine aminotransferase. I. Purification and properties. J Biol Chem. 1967 Jan 10; 242(1):91-100. PMID: 6016336.
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      573. SAIER M. Coccidioidomycosis: case report. Am Pract Dig Treat. 1959 Nov; 10:1948-51. PMID: 14440806.
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      574. SAIER M, HECKER S, KRUPP M. Treatment of status asthmaticus complicated by vasomotor collapse. J Allergy. 1959 Jan-Feb; 30(1):61-5. PMID: 13620446.
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      575. KRUPP MA, SAIER M, KEDDIE F, TANNER R, SNELL AM. Experience with cortisone and ACTH in a private clinic. Calif Med. 1951 Jul; 75(1):6-10. PMID: 14848715.
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