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Jay Desgrosellier

Title	Assistant Adjunct Professor
School	University of California, San Diego
Department	Pathology
Address	9500 Gilman Drive #0803 CA La Jolla 92093
Phone	858-822-2369
vCard	Download vCard

Research

Research Activities and Funding

Regulation of Src by integrins during metastasis
NIH/NCI F32CA123774Jun 1, 2007 - May 31, 2009
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

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Seguin L, Camargo MF, Wettersten HI, Kato S, Desgrosellier J, von Schalscha T, Elliott KC, Cosset E, Lesperance J, Weis SM, Cheresh DA. Galectin-3, a druggable vulnerability for KRAS-addicted cancers. Cancer Discov. 2017 Sep 11. PMID: 28893801.

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Seguin L, Desgrosellier J, Weis SM, Cheresh DA. Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 2015 Apr; 25(4):234-40. PMID: 25572304.

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Desgrosellier J, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA. Integrin avß3 Drives Slug Activation and Stemness in the Pregnant and Neoplastic Mammary Gland. Dev Cell. 2014 Aug 11; 30(3):295-308. PMID: 25117682.

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Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier J, Anand S, Weis SM, Cheresh DA. An integrin ß3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68. PMID: 24747441.

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Garmy-Susini B, Avraamides CJ, Desgrosellier J, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Ka activates integrin a4ß1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. PMID: 23671068.

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Lau SK, Shields DJ, Murphy EA, Desgrosellier J, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA. EGFR-mediated carcinoma cell metastasis mediated by integrin avß5 depends on activation of c-Src and cleavage of MUC1. PLoS One. 2012; 7(5):e36753. PMID: 22586492.

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Huang M, Anand S, Murphy EA, Desgrosellier J, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA. EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene. 2012 May 31; 31(22):2783-93. PMID: 21963850.

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Shields DJ, Murphy EA, Desgrosellier J, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA. Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene. 2011 May 5; 30(18):2123-34. PMID: 21242978.

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Desgrosellier J, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2010 Jan; 10(1):9-22. PMID: 20029421.

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Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier J, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5):2189-94. PMID: 20080647.

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Desgrosellier J, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med. 2009 Oct; 15(10):1163-9. PMID: 19734908.

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Park HJ, Ward SM, Desgrosellier J, Georgescu SP, Papageorge AG, Zhuang X, Barnett JV, Galper JB. Transforming growth factor beta regulates the expression of the M2 muscarinic receptor in atrial myocytes via an effect on RhoA and p190RhoGAP. J Biol Chem. 2006 Jul 21; 281(29):19995-20002. PMID: 16707504.

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Desgrosellier J, Mundell NA, McDonnell MA, Moses HL, Barnett JV. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol. 2005 Apr 1; 280(1):201-10. PMID: 15766759.

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Barnett JV, Desgrosellier J. Early events in valvulogenesis: a signaling perspective. Birth Defects Res C Embryo Today. 2003 Feb; 69(1):58-72. PMID: 12768658.

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Ward SM, Desgrosellier J, Zhuang X, Barnett JV, Galper JB. Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. J Biol Chem. 2002 Dec 20; 277(51):50183-9. PMID: 12393881.

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Russo J, Barnes A, Berger K, Desgrosellier J, Henderson J, Kanters A, Merkov L. 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal. BMC Pharmacol. 2002; 2:4. PMID: 11872149.

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Lai YT, Beason KB, Brames GP, Desgrosellier J, Cleggett MC, Shaw MV, Brown CB, Barnett JV. Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev Biol. 2000 Jun 1; 222(1):1-11. PMID: 10885742.

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Ayala JE, Streeper RS, Desgrosellier J, Durham SK, Suwanichkul A, Svitek CA, Goldman JK, Barr FG, Powell DR, O'Brien RM. Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence. Diabetes. 1999 Sep; 48(9):1885-9. PMID: 10480625.

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