Jay Desgrosellier

Title(s)Assistant Adjunct Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the stem cell niche in aggressive breast cancers
    Susan G. Komen Career Catalyst Research Grant CCR15330839Sep 10, 2015 - Sep 9, 2018
    Role: Principal Investigator
    Integrin avß3 drives an EMT-independent role for Slug in cancer stemness
    American Cancer Society Pilot Project Grant provided through the Moores Cancer Center Institutional Research Grant 70-002Dec 1, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Examining oncogenicity and metastatic potential in pregnancy-induced mammary stem cells
    California Breast Cancer Research Program Innovative, Developmental & Exploratory AwardAug 1, 2012 - Jan 31, 2014
    Role: Principal Investigator
    Regulation of Src by integrins during metastasis
    NIH F32CA123774Jun 1, 2007 - May 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stem-like breast cancer cells in the activated state resist genetic stress via TGFBI-ZEB1. NPJ Breast Cancer. 2022 Jan 13; 8(1):5. Sun Q, Wang Y, Officer A, Pecknold B, Lee G, Harismendy O, Desgrosellier JS. PMID: 35027548; PMCID: PMC8758745.
      View in: PubMed   Mentions: 2  
    2. A precision approach to breast cancer treatment based on cell lineage-specific vulnerabilities. Oncoscience. 2021; 8:76-79. Desgrosellier JS. PMID: 34124284; PMCID: PMC8192127.
      View in: PubMed   Mentions:
    3. Combined Bcl-2/Src inhibition synergize to deplete stem-like breast cancer cells. Cancer Lett. 2019 08 10; 457:40-46. Sun Q, Wang Y, Desgrosellier JS. PMID: 31078737.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    4. Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis. J Clin Invest. 2018 01 02; 128(1):531-544. Sun Q, Lesperance J, Wettersten H, Luterstein E, DeRose YS, Welm A, Cheresh DA, Desgrosellier JS. PMID: 29227280; PMCID: PMC5749527.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    5. Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Cancer Discov. 2017 12; 7(12):1464-1479. Seguin L, Camargo MF, Wettersten HI, Kato S, Desgrosellier JS, von Schalscha T, Elliott KC, Cosset E, Lesperance J, Weis SM, Cheresh DA. PMID: 28893801; PMCID: PMC5718959.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    6. Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 2015 Apr; 25(4):234-40. Seguin L, Desgrosellier JS, Weis SM, Cheresh DA. PMID: 25572304; PMCID: PMC4380531.
      View in: PubMed   Mentions: 290     Fields:    Translation:HumansCells
    7. Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell. 2014 Aug 11; 30(3):295-308. Desgrosellier JS, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA. PMID: 25117682; PMCID: PMC4147869.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    8. An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68. Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier JS, Anand S, Weis SM, Cheresh DA. PMID: 24747441; PMCID: PMC4105198.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansAnimalsCells
    9. PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PMID: 23671068; PMCID: PMC3670313.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    10. EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. PLoS One. 2012; 7(5):e36753. Lau SK, Shields DJ, Murphy EA, Desgrosellier JS, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA. PMID: 22586492; PMCID: PMC3346745.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    11. EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene. 2012 May 31; 31(22):2783-93. Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA. PMID: 21963850; PMCID: PMC3711644.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    12. Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene. 2011 May 05; 30(18):2123-34. Shields DJ, Murphy EA, Desgrosellier JS, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA. PMID: 21242978; PMCID: PMC3104672.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    13. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2010 Jan; 10(1):9-22. Desgrosellier JS, Cheresh DA. PMID: 20029421; PMCID: PMC4383089.
      View in: PubMed   Mentions: 1367     Fields:    Translation:HumansAnimalsCells
    14. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):2189-94. Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA. PMID: 20080647; PMCID: PMC2836678.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    15. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med. 2009 Oct; 15(10):1163-9. Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA. PMID: 19734908; PMCID: PMC2759406.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    16. Transforming growth factor beta regulates the expression of the M2 muscarinic receptor in atrial myocytes via an effect on RhoA and p190RhoGAP. J Biol Chem. 2006 Jul 21; 281(29):19995-20002. Park HJ, Ward SM, Desgrosellier JS, Georgescu SP, Papageorge AG, Zhuang X, Barnett JV, Galper JB. PMID: 16707504.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol. 2005 Apr 01; 280(1):201-10. Desgrosellier JS, Mundell NA, McDonnell MA, Moses HL, Barnett JV. PMID: 15766759.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    18. Early events in valvulogenesis: a signaling perspective. Birth Defects Res C Embryo Today. 2003 Feb; 69(1):58-72. Barnett JV, Desgrosellier JS. PMID: 12768658.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    19. Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. J Biol Chem. 2002 Dec 20; 277(51):50183-9. Ward SM, Desgrosellier JS, Zhuang X, Barnett JV, Galper JB. PMID: 12393881.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    20. 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal. BMC Pharmacol. 2002; 2:4. Russo J, Barnes A, Berger K, Desgrosellier J, Henderson J, Kanters A, Merkov L. PMID: 11872149; PMCID: PMC65698.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev Biol. 2000 Jun 01; 222(1):1-11. Lai YT, Beason KB, Brames GP, Desgrosellier JS, Cleggett MC, Shaw MV, Brown CB, Barnett JV. PMID: 10885742.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    22. Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence. Diabetes. 1999 Sep; 48(9):1885-9. Ayala JE, Streeper RS, Desgrosellier JS, Durham SK, Suwanichkul A, Svitek CA, Goldman JK, Barr FG, Powell DR, O'Brien RM. PMID: 10480625.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
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