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Jay Desgrosellier

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0803
La Jolla CA 92093
Phone858-822-2369
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the stem cell niche in aggressive breast cancers
    Susan G. Komen Career Catalyst Research Grant CCR15330839Sep 10, 2015 - Sep 9, 2018
    Role: Principal Investigator
    Integrin avß3 drives an EMT-independent role for Slug in cancer stemness
    American Cancer Society Pilot Project Grant provided through the Moores Cancer Center Institutional Research Grant 70-002Dec 1, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Examining oncogenicity and metastatic potential in pregnancy-induced mammary stem cells
    California Breast Cancer Research Program Innovative, Developmental & Exploratory AwardAug 1, 2012 - Jan 31, 2014
    Role: Principal Investigator
    Regulation of Src by integrins during metastasis
    NIH/NCI F32CA123774Jun 1, 2007 - May 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sun Q, Lesperance J, Wettersten H, Luterstein E, DeRose YS, Welm A, Cheresh DA, Desgrosellier J. Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis. J Clin Invest. 2018 Jan 02; 128(1):531-544. PMID: 29227280.
      View in: PubMed
    2. Seguin L, Camargo MF, Wettersten HI, Kato S, Desgrosellier J, von Schalscha T, Elliott KC, Cosset E, Lesperance J, Weis SM, Cheresh DA. Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Cancer Discov. 2017 12; 7(12):1464-1479. PMID: 28893801.
      View in: PubMed
    3. Seguin L, Desgrosellier J, Weis SM, Cheresh DA. Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 2015 Apr; 25(4):234-40. PMID: 25572304; PMCID: PMC4380531.
    4. Desgrosellier J, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, Yebra M, Shattil SJ, Cheresh DA. Integrin avß3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell. 2014 Aug 11; 30(3):295-308. PMID: 25117682; PMCID: PMC4147869.
    5. Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier J, Anand S, Weis SM, Cheresh DA. An integrin ß3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68. PMID: 24747441.
      View in: PubMed
    6. Garmy-Susini B, Avraamides CJ, Desgrosellier J, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Ka activates integrin a4ß1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. PMID: 23671068.
      View in: PubMed
    7. Lau SK, Shields DJ, Murphy EA, Desgrosellier J, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA. EGFR-mediated carcinoma cell metastasis mediated by integrin avß5 depends on activation of c-Src and cleavage of MUC1. PLoS One. 2012; 7(5):e36753. PMID: 22586492; PMCID: PMC3346745.
    8. Huang M, Anand S, Murphy EA, Desgrosellier J, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA. EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene. 2012 May 31; 31(22):2783-93. PMID: 21963850; PMCID: PMC3711644.
    9. Shields DJ, Murphy EA, Desgrosellier J, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA. Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene. 2011 May 05; 30(18):2123-34. PMID: 21242978; PMCID: PMC3104672.
    10. Desgrosellier J, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2010 Jan; 10(1):9-22. PMID: 20029421; PMCID: PMC4383089.
    11. Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier J, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):2189-94. PMID: 20080647; PMCID: PMC2836678.
    12. Desgrosellier J, Barnes LA, Shields DJ, Huang M, Lau SK, Prévost N, Tarin D, Shattil SJ, Cheresh DA. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med. 2009 Oct; 15(10):1163-9. PMID: 19734908; PMCID: PMC2759406.
    13. Park HJ, Ward SM, Desgrosellier J, Georgescu SP, Papageorge AG, Zhuang X, Barnett JV, Galper JB. Transforming growth factor beta regulates the expression of the M2 muscarinic receptor in atrial myocytes via an effect on RhoA and p190RhoGAP. J Biol Chem. 2006 Jul 21; 281(29):19995-20002. PMID: 16707504.
      View in: PubMed
    14. Desgrosellier J, Mundell NA, McDonnell MA, Moses HL, Barnett JV. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol. 2005 Apr 01; 280(1):201-10. PMID: 15766759.
      View in: PubMed
    15. Barnett JV, Desgrosellier J. Early events in valvulogenesis: a signaling perspective. Birth Defects Res C Embryo Today. 2003 Feb; 69(1):58-72. PMID: 12768658.
      View in: PubMed
    16. Ward SM, Desgrosellier J, Zhuang X, Barnett JV, Galper JB. Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. J Biol Chem. 2002 Dec 20; 277(51):50183-9. PMID: 12393881.
      View in: PubMed
    17. Russo J, Barnes A, Berger K, Desgrosellier J, Henderson J, Kanters A, Merkov L. 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal. BMC Pharmacol. 2002; 2:4. PMID: 11872149; PMCID: PMC65698.
    18. Lai YT, Beason KB, Brames GP, Desgrosellier J, Cleggett MC, Shaw MV, Brown CB, Barnett JV. Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev Biol. 2000 Jun 01; 222(1):1-11. PMID: 10885742.
      View in: PubMed