Leonard Deftos

Title(s)Senate Emeritus, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Neuroendocrine Cancer: Tumor Regulation by PTHrP In Vitro and In Vivo
    NIH I01BX000133Oct 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Molecular Epidemiology and Action of PTHrP in PCa
    NIH R01DK060588May 1, 2001 - Apr 30, 2006
    Role: Principal Investigator
    NIH R01CA071347Sep 30, 1995 - Apr 30, 2001
    Role: Principal Investigator
    NIH R01CA049474Mar 15, 1990 - Feb 29, 1996
    Role: Principal Investigator
    NIH R01CA047373Sep 1, 1988 - Jul 31, 1994
    Role: Principal Investigator
    NIH R01DK025604May 1, 1979 - Dec 31, 1988
    Role: Principal Investigator
    NIH R01AM025604May 1, 1979 - Jun 30, 1988
    Role: Principal Investigator
    NIH R01AR015888May 1, 1976 - Jun 30, 1996
    Role: Principal Investigator
    NIH R01AM015888May 1, 1976 - Apr 30, 1986
    Role: Principal Investigator
    NIH T32AR007048Jul 1, 1975 - Jun 30, 2002
    Role: Principal Investigator
    NIH T32AM007048Jul 1, 1975 - Jun 30, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Injury, Illness, and Mental Health Risks in United States Domestic Mariners. J Occup Environ Med. 2020 10; 62(10):839-841. Lefkowitz RY, Null DB, Slade MD, Redlich CA. PMID: 32769797.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    2. Imaging examination, diagnosis, and control and prevention of nosocomial infection for coronavirus disease 2019: Expert consensus of Hunan radiologist. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28; 45(3):221-228. Liu J, Wang W. PMID: 32386011.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    3. Parathyroid hormone related-protein promotes epithelial-to-mesenchymal transition in prostate cancer. PLoS One. 2014; 9(1):e85803. Ongkeko WM, Burton D, Kiang A, Abhold E, Kuo SZ, Rahimy E, Yang M, Hoffman RM, Wang-Rodriguez J, Deftos LJ. PMID: 24465715; PMCID: PMC3899059.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    4. Deletion of the gene encoding calcitonin and calcitonin gene-related peptide α does not affect the outcome of severe infection in mice. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):151-5. Tuvim MJ, Clement CG, Huang ES, Cote GJ, Evans SE, Lei X, Deftos LJ, Gagel RF, Dickey BF. PMID: 23526213; PMCID: PMC3727888.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Hypercalcemia in disseminated coccidioidomycosis: expression of parathyroid hormone-related peptide is characteristic of granulomatous inflammation. Clin Infect Dis. 2012 Oct; 55(7):e61-6. Fierer J, Burton DW, Haghighi P, Deftos LJ. PMID: 22670039.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    6. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012 May 23; 4(135):135ra66. Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL. PMID: 22623742; PMCID: PMC3725981.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    7. Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1. Pancreas. 2011 May; 40(4):634-7. Milanesi A, Yu R, Geller SA, Burton D, Deftos LJ, Wolin EM. PMID: 21483254.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Prognostic implications of parathyroid hormone-related protein in males and females with non--small-cell lung cancer. Clin Lung Cancer. 2011 May; 12(3):197-205. Montgrain PR, Deftos LJ, Arenberg D, Tipps A, Quintana R, Carskadon S, Hastings RH. PMID: 21663864.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    9. Knockdown of the β(1) integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. Int J Cancer. 2011 Dec 15; 129(12):2905-15. Grzesiak JJ, Tran Cao HS, Burton DW, Kaushal S, Vargas F, Clopton P, Snyder CS, Deftos LJ, Hoffman RM, Bouvet M. PMID: 21491421; PMCID: PMC3167925.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    10. PTHrP stimulates prostate cancer cell growth and upregulates aldo-keto reductase 1C3. Cancer Lett. 2011 Jul 01; 306(1):52-9. Downs TM, Burton DW, Araiza FL, Hastings RH, Deftos LJ. PMID: 21444150.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. Combinatorial library discovery of small molecule inhibitors of lung cancer proliferation and parathyroid hormone-related protein expression. Cancer Biol Ther. 2010 Nov 15; 10(10):1067-75. Hastings RH, Burton DW, Nefzi A, Montgrain PR, Quintana R, Deftos LJ. PMID: 20890111.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    12. Cell cycle actions of parathyroid hormone-related protein in non-small cell lung carcinoma. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L578-85. Hastings RH, Montgrain PR, Quintana R, Rascon Y, Deftos LJ, Healy E. PMID: 19633068; PMCID: PMC2770787.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. Parathyroid hormone-related protein varies with sex and androgen status in nonsmall cell lung cancer. Cancer. 2007 Sep 15; 110(6):1313-20. Montgrain PR, Quintana R, Rascon Y, Burton DW, Deftos LJ, Casillas A, Hastings RH. PMID: 17676588.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    14. Incidental finding of metastatic papillary thyroid carcinoma in a patient with primary hyperparathyroidism. Endocr Pract. 2007 Jul-Aug; 13(4):380-3. Lee JK, Obrzut SL, Yi ES, Deftos LJ, Bouvet M. PMID: 17669714.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells. Surgery. 2007 Jun; 141(6):804-14. Grzesiak JJ, Smith KC, Burton DW, Deftos LJ, Bouvet M. PMID: 17560257; PMCID: PMC1994963.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    16. Congenital craniopharyngioma and hypercalcemia induced by parathyroid hormone-related protein. Endocr Pract. 2007 Jan-Feb; 13(1):67-71. Brown JL, Burton DW, Deftos LJ, Smith AA, Pincus DW, Haller MJ. PMID: 17360305.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Causes of hypercalcemia in a population of military veterans in the United States. Endocr Pract. 2006 Sep-Oct; 12(5):535-41. Newman EM, Bouvet M, Borgehi S, Herold DA, Deftos LJ. PMID: 17002928.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Games of hormones: the para-endocrinology of sport. Endocr Pract. 2006 Jul-Aug; 12(4):472-4. Deftos LJ. PMID: 16901804.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    19. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clin Cancer Res. 2006 Apr 15; 12(8):2602-6. Yang M, Burton DW, Geller J, Hillegonds DJ, Hastings RH, Deftos LJ, Hoffman RM. PMID: 16638872.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Identification of DU 145 prostate cancer cell proteins that bind to the carboxy-terminal peptide of human PTHrP in vitro. Peptides. 2006 Jul; 27(7):1898-901. Grzesiak JJ, Burton DW, Deftos LJ, Bouvet M. PMID: 16513210.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Combination therapy for osteoporosis: a counter-regulatory conundrum. Nat Clin Pract Rheumatol. 2006 Feb; 2(2):64-5. Deftos LJ. PMID: 16932655.
      View in: PubMed   Mentions:    Fields:    
    22. Sex-specific survival advantage with parathyroid hormone-related protein in non-small cell lung carcinoma patients. Clin Cancer Res. 2006 Jan 15; 12(2):499-506. Hastings RH, Laux AM, Casillas A, Xu R, Lukas Z, Ernstrom K, Deftos LJ. PMID: 16428492.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    23. A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export. Endocrinology. 2006 Feb; 147(2):990-8. Pache JC, Burton DW, Deftos LJ, Hastings RH. PMID: 16293661.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. 41Ca and accelerator mass spectrometry to monitor calcium metabolism in end stage renal disease patients. Clin Chem. 2005 Nov; 51(11):2095-102. Fitzgerald RL, Hillegonds DJ, Burton DW, Griffin TL, Mullaney S, Vogel JS, Deftos LJ, Herold DA. PMID: 16141289.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    25. Heat shock protein-70 expressed on the surface of cancer cells binds parathyroid hormone-related protein in vitro. Endocrinology. 2005 Aug; 146(8):3567-76. Grzesiak JJ, Smith KC, Chalberg C, Truong C, Burton DW, Deftos LJ, Bouvet M. PMID: 15878959.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. Hypercalcemia and local production of parathyroid hormone-related protein by a perisellar rhabdomyosarcoma after remote pituitary irradiation. Endocr Pract. 2005 May-Jun; 11(3):184-9. Florez JC, Burton DW, Arnell PM, Deftos LJ, Klibanski A. PMID: 16239205.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. Int J Cancer. 2005 Apr 20; 114(4):522-30. Grzesiak JJ, Smith KC, Burton DW, Deftos LJ, Bouvet M. PMID: 15609321.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Direct evidence that PTHrP expression promotes prostate cancer progression in bone. Biochem Biophys Res Commun. 2005 Feb 11; 327(2):468-72. Deftos LJ, Barken I, Burton DW, Hoffman RM, Geller J. PMID: 15629138.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    29. Type I collagen and divalent cation shifts disrupt cell-cell adhesion, increase migration, and decrease PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells. Int J Gastrointest Cancer. 2005; 36(3):131-46. Grzesiak JJ, Smith KC, Chalberg C, Burton DW, Deftos LJ, Bouvet M. PMID: 16720909.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Parathyroid hormone-related protein expression is correlated with clinical course in patients with glial tumors. Cancer. 2004 Dec 01; 101(11):2622-8. Pardo FS, Lien WW, Fox HS, Efird JT, Aguilera JA, Burton DW, Deftos LJ. PMID: 15517575.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells. Pancreas. 2004 Aug; 29(2):85-92. Grzesiak JJ, Clopton P, Chalberg C, Smith K, Burton DW, Silletti S, Moossa AR, Deftos LJ, Bouvet M. PMID: 15257098.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. Parathyroid hormone-related protein regulates apoptosis in lung cancer cells through protein kinase A. Am J Physiol Cell Physiol. 2004 Dec; 287(6):C1616-22. Hastings RH, Araiza F, Burton DW, Bedley M, Deftos LJ. PMID: 15282196.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    33. Role of parathyroid hormone-related protein in lung cancer cell survival. Chest. 2004 May; 125(5 Suppl):150S. Hastings RH, Araiza F, Burton DW, Deftos LJ. PMID: 15136475.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    34. Metachronous double parathyroid adenomas involving two different cell types: chief cell and oxyphil cell. Endocr Pract. 2003 Nov-Dec; 9(6):522-5. Zhou W, Katz MH, Deftos LJ, Snyder CS, Baird S, Bouvet M. PMID: 14715480.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Amino-terminal and midmolecule parathyroid hormone-related protein, phosphatidylcholine, and type II cell proliferation in silica-injured lung. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1312-22. Hastings RH, Quintana RA, Sandoval R, Burton DW, Deftos LJ. PMID: 12922983.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Parathyroid hormone-related protein ameliorates death receptor-mediated apoptosis in lung cancer cells. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1429-36. Hastings RH, Araiza F, Burton DW, Zhang L, Bedley M, Deftos LJ. PMID: 12917104.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    37. Proapoptotic effects of parathyroid hormone-related protein in type II pneumocytes. Am J Respir Cell Mol Biol. 2003 Dec; 29(6):733-42. Hastings RH, Quintana RA, Sandoval R, Duey D, Rascon Y, Burton DW, Deftos LJ. PMID: 12791677.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    38. Thymic parathyroid carcinoma and postoperative hungry bone syndrome. Endocr Pract. 2003 Mar-Apr; 9(2):152-6. Chandran M, Deftos LJ, Stuenkel CA, Haghighi P, Orloff LA. PMID: 12917079.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    39. Parathyroid hormone-related protein response to hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 Jun; 282(6):L1198-208. Hastings RH, Ryan RM, D'Angio CT, Holm BA, Patel A, Quintana R, Biederman E, Burton DW, Deftos LJ. PMID: 12003775.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    40. Parathyroid hormone-related protein as a novel tumor marker in pancreatic adenocarcinoma. Pancreas. 2002 Apr; 24(3):284-90. Bouvet M, Nardin SR, Burton DW, Lee NC, Yang M, Wang X, Baranov E, Behling C, Moossa AR, Hoffman RM, Deftos LJ. PMID: 11893937.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    41. Harvard v. Canada: the myc mouse that still squeaks in the maze of biopatent law. Acad Med. 2001 Jul; 76(7):684-92. Deftos LJ. PMID: 11448821.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    42. Medical and scientific organizations and scientific evidence in U.S. trials: lessons from European legal theory. Acad Med. 1999 Mar; 74(3):231-5. Deftos LJ. PMID: 10099641.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Genomic torts: the law of the future--the duty of physicians to disclose the presence of a genetic disease to the relatives of their patients with the disease. Spec Law Dig Health Care Law. 1998 Sep; (234):9-41. Deftos LJ. PMID: 10185166.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. The evolving duty to disclose the presence of genetic disease to relatives. Acad Med. 1998 Sep; 73(9):962-8. Deftos LJ. PMID: 9759098.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    45. Granins and prostate cancer. Urology. 1998 May; 51(5A Suppl):141-5. Deftos LJ, Abrahamsson PA. PMID: 9610570.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    46. Granin-A, parathyroid hormone-related protein, and calcitonin gene products in neuroendocrine prostate cancer. Prostate Suppl. 1998; 8:23-31. Deftos LJ. PMID: 9690660.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells