Dannielle Engle

Title(s)Assistant Adjunct Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids. ACS Appl Bio Mater. 2024 Dec 16; 7(12):8489-8502. Rosas JM, Campanale JP, Harwood JL, Li L, Bae R, Cheng S, Tsou JM, Kaiser KM, Engle DD, Montell DJ, Pitenis AA. PMID: 39576883; PMCID: PMC11653396.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury. Stem Cells. 2024 Apr 15; 42(4):385-401. Tremblay JR, Ortiz JA, Quijano JC, Zook HN, Erdem N, LeBon JM, Li W, Jou K, Tsark W, Mann JR, Kozlowski MT, Tirrell DA, Esni F, Engle DD, Riggs AD, Ku HT. PMID: 38206366; PMCID: PMC11016848.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. The effect of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids. JCI Insight. 2024 Jan 09; 9(1). Lumibao JC, Okhovat SR, Peck KL, Lin X, Lande K, Yomtoubian S, Ng I, Tiriac H, Lowy AM, Zou J, Engle DD. PMID: 38051586; PMCID: PMC10906458.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. Nat Commun. 2023 Dec 06; 14(1):7791. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 38057326; PMCID: PMC10700526.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2023 09 15; 83(18):3001-3012. Gulay KCM, Zhang X, Pantazopoulou V, Patel J, Esparza E, Pran Babu DS, Ogawa S, Weitz J, Ng I, Mose ES, Pu M, Engle DD, Lowy AM, Tiriac H. PMID: 37378556; PMCID: PMC10502451.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    6. Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression. bioRxiv. 2023 Sep 14. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 37745372; PMCID: PMC10515810.
      View in: PubMed   Mentions:
    7. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun. 2023 09 06; 14(1):5195. Antal CE, Oh TG, Aigner S, Luo EC, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. PMID: 37673892; PMCID: PMC10482938.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. The impact of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids. bioRxiv. 2023 May 09. Lumibao JC, Okhovat SR, Peck KL, Lin X, Lande K, Zou J, Engle DD. PMID: 36747742; PMCID: PMC9900943.
      View in: PubMed   Mentions:
    9. Altered glycosylation in pancreatic cancer and beyond. J Exp Med. 2022 06 06; 219(6). Lumibao JC, Tremblay JR, Hsu J, Engle DD. PMID: 35522218; PMCID: PMC9086500.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    10. Author Correction: The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2021 Mar; 591(7851):E28. Seifert L, Werba G, Tiwari S, Ly NNG, Alothman S, Alqunaibit D, Avanzi A, Barilla R, Daley D, Greco SH, Torres-Hernandez A, Pergamo M, Ochi A, Zambirinis CP, Pansari M, Rendon M, Tippens D, Hundeyin M, Mani VR, Hajdu C, Engle D, Miller G. PMID: 33707632.
      View in: PubMed   Mentions: 5     Fields:    
    11. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020 07 06; 217(7). Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. PMID: 32441762; PMCID: PMC7336299.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    12. Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer. Clin Cancer Res. 2019 11 15; 25(22):6742-6755. Ponz-Sarvise M, Corbo V, Tiriac H, Engle DD, Frese KK, Oni TE, Hwang CI, Öhlund D, Chio IIC, Baker LA, Filippini D, Wright K, Bapiro TE, Huang P, Smith P, Yu KH, Jodrell DI, Park Y, Tuveson DA. PMID: 31492749; PMCID: PMC6858952.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    13. The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. Science. 2019 06 21; 364(6446):1156-1162. Engle DD, Tiriac H, Rivera KD, Pommier A, Whalen S, Oni TE, Alagesan B, Lee EJ, Yao MA, Lucito MS, Spielman B, Da Silva B, Schoepfer C, Wright K, Creighton B, Afinowicz L, Yu KH, Grützmann R, Aust D, Gimotty PA, Pollard KS, Hruban RH, Goggins MG, Pilarsky C, Park Y, Pappin DJ, Hollingsworth MA, Tuveson DA. PMID: 31221853; PMCID: PMC6705393.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    14. Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts. Cancer Discov. 2019 08; 9(8):1102-1123. Elyada E, Bolisetty M, Laise P, Flynn WF, Courtois ET, Burkhart RA, Teinor JA, Belleau P, Biffi G, Lucito MS, Sivajothi S, Armstrong TD, Engle DD, Yu KH, Hao Y, Wolfgang CL, Park Y, Preall J, Jaffee EM, Califano A, Robson P, Tuveson DA. PMID: 31197017; PMCID: PMC6727976.
      View in: PubMed   Mentions: 779     Fields:    Translation:HumansAnimalsCells
    15. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov. 2018 09; 8(9):1112-1129. Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville TDD, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, Palmaira RLD, Javed AA, Huynh JC, Johnson M, Arora K, Robine N, Shah M, Sanghvi R, Goetz AB, Lowder CY, Martello L, Driehuis E, LeComte N, Askan G, Iacobuzio-Donahue CA, Clevers H, Wood LD, Hruban RH, Thompson E, Aguirre AJ, Wolpin BM, Sasson A, Kim J, Wu M, Bucobo JC, Allen P, Sejpal DV, Nealon W, Sullivan JD, Winter JM, Gimotty PA, Grem JL, DiMaio DJ, Buscaglia JM, Grandgenett PM, Brody JR, Hollingsworth MA, O'Kane GM, Notta F, Kim E, Crawford JM, Devoe C, Ocean A, Wolfgang CL, Yu KH, Li E, Vakoc CR, Hubert B, Fischer SE, Wilson JM, Moffitt R, Knox J, Krasnitz A, Gallinger S, Tuveson DA. PMID: 29853643; PMCID: PMC6125219.
      View in: PubMed   Mentions: 463     Fields:    Translation:HumansCells
    16. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. Cancer Res. 2018 08 01; 78(15):4253-4269. Quaranta V, Rainer C, Nielsen SR, Raymant ML, Ahmed MS, Engle DD, Taylor A, Murray T, Campbell F, Palmer DH, Tuveson DA, Mielgo A, Schmid MC. PMID: 29789416; PMCID: PMC6076440.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    17. Dynamic changes during the treatment of pancreatic cancer. Oncotarget. 2018 Mar 13; 9(19):14764-14790. Wolff RA, Wang-Gillam A, Alvarez H, Tiriac H, Engle D, Hou S, Groff AF, San Lucas A, Bernard V, Allenson K, Castillo J, Kim D, Mulu F, Huang J, Stephens B, Wistuba II, Katz M, Varadhachary G, Park Y, Hicks J, Chinnaiyan A, Scampavia L, Spicer T, Gerhardinger C, Maitra A, Tuveson D, Rinn J, Lizee G, Yee C, Levine AJ. PMID: 29599906; PMCID: PMC5871077.
      View in: PubMed   Mentions: 13     Fields:    
    18. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med. 2017 03 06; 214(3):579-596. Öhlund D, Handly-Santana A, Biffi G, Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA, Lee EJ, Chio II, Hwang CI, Tiriac H, Baker LA, Engle DD, Feig C, Kultti A, Egeblad M, Fearon DT, Crawford JM, Clevers H, Park Y, Tuveson DA. PMID: 28232471; PMCID: PMC5339682.
      View in: PubMed   Mentions: 1097     Fields:    Translation:HumansAnimalsCells
    19. Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol. 2016 06 28; 18(7):822. Nielsen SR, Quaranta V, Linford A, Emeagi P, Rainer C, Santos A, Ireland L, Sakai T, Sakai K, Kim YS, Engle D, Campbell F, Palmer D, Ko JH, Tuveson DA, Hirsch E, Mielgo A, Schmid MC. PMID: 27350447.
      View in: PubMed   Mentions: 6     Fields:    
    20. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol. 2016 05; 18(5):549-60. Nielsen SR, Quaranta V, Linford A, Emeagi P, Rainer C, Santos A, Ireland L, Sakai T, Sakai K, Kim YS, Engle D, Campbell F, Palmer D, Ko JH, Tuveson DA, Hirsch E, Mielgo A, Schmid MC. PMID: 27088855; PMCID: PMC4894551.
      View in: PubMed   Mentions: 224     Fields:    Translation:HumansAnimalsCells
    21. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016 Apr 14; 532(7598):245-9. Seifert L, Werba G, Tiwari S, Giao Ly NN, Alothman S, Alqunaibit D, Avanzi A, Barilla R, Daley D, Greco SH, Torres-Hernandez A, Pergamo M, Ochi A, Zambirinis CP, Pansari M, Rendon M, Tippens D, Hundeyin M, Mani VR, Hajdu C, Engle D, Miller G. PMID: 27049944; PMCID: PMC4833566.
      View in: PubMed   Mentions: 331     Fields:    Translation:HumansAnimalsCells
    22. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med. 2015 Nov 16; 212(12):2077-94. Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, Seifert L, Daley D, Greco SH, Deutsch M, Jonnadula S, Torres-Hernandez A, Tippens D, Pushalkar S, Eisenthal A, Saxena D, Ahn J, Hajdu C, Engle DD, Tuveson D, Miller G. PMID: 26481685; PMCID: PMC4647258.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    23. Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. Cancer Res. 2015 Sep 01; 75(17):3529-42. Roy I, McAllister DM, Gorse E, Dixon K, Piper CT, Zimmerman NP, Getschman AE, Tsai S, Engle DD, Evans DB, Volkman BF, Kalyanaraman B, Dwinell MB. PMID: 26330165; PMCID: PMC4560104.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    24. Model organoids provide new research opportunities for ductal pancreatic cancer. Mol Cell Oncol. 2016 Jan; 3(1):e1014757. Boj SF, Hwang CI, Baker LA, Engle DD, Tuveson DA, Clevers H. PMID: 27308531; PMCID: PMC4845167.
      View in: PubMed   Mentions: 33  
    25. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015 Jan 15; 160(1-2):324-38. Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA. PMID: 25557080; PMCID: PMC4334572.
      View in: PubMed   Mentions: 996     Fields:    Translation:HumansAnimals
    26. p53 mutations change phosphatidylinositol acyl chain composition. Cell Rep. 2015 Jan 06; 10(1):8-19. Naguib A, Bencze G, Engle DD, Chio II, Herzka T, Watrud K, Bencze S, Tuveson DA, Pappin DJ, Trotman LC. PMID: 25543136; PMCID: PMC4287966.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    27. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. PMID: 25259922; PMCID: PMC4177038.
      View in: PubMed   Mentions: 531     Fields:    Translation:HumansAnimalsCells
    28. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell. 2012 Feb 03; 10(2):183-97. Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM. PMID: 22305568; PMCID: PMC3277444.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    29. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. PMID: 21724834; PMCID: PMC3134085.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
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