Judith Varner

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailjvarner@ucsd.edu
ORCID ORCID Icon0000-0002-9251-0600 Additional info
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    Collapse Overview 
    Collapse Overview
    Research Interests
    Mechanisms regulating tumor angiogenesis, lymphangiogenesis, inflammation and metastasis.

    Education and Training
    AB - Chemistry, Duke University, Durham, NC - 1976-1980
    Fulbright Fellowship - University of Basel, Basel, Switzerland - 1980-1981
    PhD - University of Basel, Basel, Switzerland - 1981-1988
    Postdoctoral fellow - Dept. Molecular Genetics, Tampa Bay Research Institute - 1988-1990
    Postdoctoral fellow - Dept. Pharmacology, University of North Carolina, Chapel Hill - 1991-1993

    Collapse Research 
    Collapse Research Activities and Funding
    Therapeutic Targeting of Macrophage PI3Kgamma in HNSCC
    NIH R01CA226909Apr 17, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Targeting the innate immune response in HNSCC
    NIH R01DE027325Sep 15, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Role of PI3Kinase in Tumor Progression and Metastasis
    NIH R01CA167426Apr 1, 2012 - Mar 31, 2023
    Role: Principal Investigator
    The lymph node microenvionment in tumor metastasis
    NIH R01CA126820Jan 7, 2008 - Dec 31, 2014
    Role: Principal Investigator
    Negative Regulation of Cell Migration by PKA
    NIH R01CA098048Jun 25, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Fibronectin-binding integrins in angiogenesis
    NIH R01CA083133Sep 1, 1999 - Jun 30, 2011
    Role: Principal Investigator
    INTEGRIN A5B1 AND TUMOR CELL GROWTH
    NIH R01CA071619Apr 1, 1997 - Jan 31, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway. Blood. 2024 Jan 25. Gu H, Chen C, Hou ZS, He XD, Xie S, Ni J, Qian C, Cheng X, Jiang T, Yang C, Roberts TM, Zheng J, Varner JA, Armstrong SA, Zhao JJ. PMID: 38271660.
      View in: PubMed   Mentions:    Fields:    
    2. Enzyme lights dual fires to promote cancer. Nature. 2023 05; 617(7959):42-43. Ghebremedhin A, Varner JA. PMID: 37076711.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation. Nat Commun. 2022 04 01; 13(1):1768. Schmid MC, Kang SW, Chen H, Paradise M, Ghebremedhin A, Kaneda MM, Chin SM, Do A, Watterson DM, Varner JA. PMID: 35365657; PMCID: PMC8975949.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). Li J, Kaneda MM, Ma J, Li M, Shepard RM, Patel K, Koga T, Sarver A, Furnari F, Xu B, Dhawan S, Ning J, Zhu H, Wu A, You G, Jiang T, Venteicher AS, Rich JN, Glass CK, Varner JA, Chen CC. PMID: 33846242; PMCID: PMC8072253.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    5. Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression. Cancer Res. 2019 10 01; 79(19):5048-5059. Wettersten HI, Weis SM, Pathria P, Von Schalscha T, Minami T, Varner JA, Cheresh DA. PMID: 31416839; PMCID: PMC6774806.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA. Adv Mater. 2019 Aug; 31(35):e1902952. Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ. PMID: 31267590; PMCID: PMC6710136.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    7. MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages. Oncogene. 2019 07; 38(28):5599-5611. Babicky ML, Harper MM, Chakedis J, Cazes A, Mose ES, Jaquish DV, French RP, Childers B, Alakus H, Schmid MC, Foubert P, Miyamoto J, Holman PJ, Walterscheid ZJ, Tang CM, Varki N, Sicklick JK, Messer K, Varner JA, Waltz SE, Lowy AM. PMID: 30967626; PMCID: PMC6625868.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    8. Targeting Tumor-Associated Macrophages in Cancer. Trends Immunol. 2019 04; 40(4):310-327. Pathria P, Louis TL, Varner JA. PMID: 30890304.
      View in: PubMed   Mentions: 398     Fields:    Translation:HumansAnimalsCells
    9. Integrin CD11b activation drives anti-tumor innate immunity. Nat Commun. 2018 12 19; 9(1):5379. Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, Anand S, Woo G, Leem C, Faridi MH, Geraghty T, Rajagopalan A, Gupta S, Ahmed M, Vazquez-Padron RI, Cheresh DA, Gupta V, Varner JA. PMID: 30568188; PMCID: PMC6300665.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    10. PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression. Cancer Immunol Res. 2017 11; 5(11):957-968. Foubert P, Kaneda MM, Varner JA. PMID: 28963139; PMCID: PMC6422969.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    11. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 09 21; 2(18). Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. PMID: 28931759; PMCID: PMC5621908.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    12. Corrigendum: PI3Kγ is a molecular switch that controls immune suppression. Nature. 2017 02 02; 542(7639):124. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27974794.
      View in: PubMed   Mentions: 17     Fields:    
    13. PI3Kγ is a molecular switch that controls immune suppression. Nature | Article Accelerated Article Preview . 2016. Megan M. Kaneda, Karen S. Messer, Natacha Ralainirina, Hongying Li, Chris Leem, Sara Gorjestani, Gyunghwi Woo, Abraham V. Nguyen, Camila C. Figueiredo, Philippe Foubert, Michael C. Schmid, Melissa Pink, David G. Winkler, Matthew Rausch, Vito J. Palombella, Jeffery Kutok, Karen McGovern, Kelly A. Frazer, Xuefeng Wu, Michael Karin, Roman Sasik, Ezra E. W. Cohen & Judith A. Varner. . View Publication.
    14. PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27642729; PMCID: PMC5479689.
      View in: PubMed   Mentions: 530     Fields:    Translation:HumansAnimalsCells
    15. Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 08; 6(8):870-85. Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. PMID: 27179037; PMCID: PMC5091937.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    16. Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer. Cancer Discov. 2016 Mar; 6(3):270-85. Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM. PMID: 26715645; PMCID: PMC4783268.
      View in: PubMed   Mentions: 241     Fields:    Translation:HumansAnimalsCells
    17. Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. PLoS One. 2015; 10(5):e0120815. Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG. PMID: 25973900; PMCID: PMC4431816.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    18. PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PMID: 23671068; PMCID: PMC3670313.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    19. PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth. PLoS One. 2013; 8(4):e60226. Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA. PMID: 23565202; PMCID: PMC3614555.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    20. The primacy of β1 integrin activation in the metastatic cascade. PLoS One. 2012; 7(10):e46576. Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ. PMID: 23056350; PMCID: PMC3463578.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    21. Myeloid cells in tumor inflammation. Vasc Cell. 2012 Sep 03; 4(1):14. Schmid MC, Varner JA. PMID: 22938502; PMCID: PMC3479419.
      View in: PubMed   Mentions: 31  
    22. Integrins in tumor angiogenesis and lymphangiogenesis. Methods Mol Biol. 2012; 757:471-86. Foubert P, Varner JA. PMID: 21909928; PMCID: PMC5433623.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    23. Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth. Cancer Res. 2011 Nov 15; 71(22):6965-75. Schmid MC, Avraamides CJ, Foubert P, Shaked Y, Kang SW, Kerbel RS, Varner JA. PMID: 21948958; PMCID: PMC3249446.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    24. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. PMID: 21665146; PMCID: PMC3144144.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimals
    25. Lymphatic endothelial heparan sulfate deficiency results in altered growth responses to vascular endothelial growth factor-C (VEGF-C). J Biol Chem. 2011 Apr 29; 286(17):14952-62. Yin X, Johns SC, Lawrence R, Xu D, Reddi K, Bishop JR, Varner JA, Fuster MM. PMID: 21343305; PMCID: PMC3083229.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    26. A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 2010 Dec 16; 116(25):5773-83. Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA. PMID: 20826718; PMCID: PMC3031419.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    27. Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J Oncol. 2010; 2010:201026. Schmid MC, Varner JA. PMID: 20490273; PMCID: PMC2871549.
      View in: PubMed   Mentions: 86  
    28. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. PMID: 20388801; PMCID: PMC2856096.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    29. Circulating endothelial progenitor cells. Methods Mol Biol. 2009; 467:139-55. Schmid MC, Varner JA. PMID: 19301669.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    30. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008 Aug; 8(8):604-17. Avraamides CJ, Garmy-Susini B, Varner JA. PMID: 18497750; PMCID: PMC2577722.
      View in: PubMed   Mentions: 439     Fields:    Translation:HumansAnimals
    31. Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. J Surg Res. 2009 Jan; 151(1):68-73. McElroy M, Hayashi K, Garmy-Susini B, Kaushal S, Varner JA, Moossa AR, Hoffman RM, Bouvet M. PMID: 18599080; PMCID: PMC2628480.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    32. Chapter 15. Methods to study myeloid cell roles in angiogenesis. Methods Enzymol. 2008; 445:343-71. Schmid MC, Varner JA. PMID: 19022067.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    33. Roles of integrins in tumor angiogenesis and lymphangiogenesis. Lymphat Res Biol. 2008; 6(3-4):155-63. Garmy-Susini B, Varner JA. PMID: 19093788; PMCID: PMC2837754.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    34. Stem cells and neurogenesis in tumors. Prog Exp Tumor Res. 2007; 39:122-129. Varner JA. PMID: 17314505.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    35. Methods to study lymphatic vessel integrins. Methods Enzymol. 2007; 426:415-38. Garmy-Susini B, Makale M, Fuster M, Varner JA. PMID: 17697894.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    36. The sticky truth about angiogenesis and thrombospondins. J Clin Invest. 2006 Dec; 116(12):3111-3. Varner JA. PMID: 17143327; PMCID: PMC1678819.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 2007 May 18; 250(1):1-8. Schmid MC, Varner JA. PMID: 17049723; PMCID: PMC3167210.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    38. Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. Radiology. 2006 Jun; 239(3):730-9. Lucidarme O, Kono Y, Corbeil J, Choi SH, Golmard JL, Varner J, Mattrey RF. PMID: 16714458.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    39. Circulating endothelial progenitor cells. Br J Cancer. 2005 Oct 17; 93(8):855-8. Garmy-Susini B, Varner JA. PMID: 16189517; PMCID: PMC2361665.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    40. Integrins: roles in cancer development and as treatment targets. Br J Cancer. 2004 Feb 09; 90(3):561-5. Jin H, Varner J. PMID: 14760364; PMCID: PMC2410157.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansCells
    41. Angiogenesis model for ultrasound contrast research: exploratory study. Acad Radiol. 2004 Jan; 11(1):4-12. Lucidarme O, Nguyen T, Kono Y, Corbeil J, Choi SH, Varner J, Mattrey RF. PMID: 14746396.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    42. The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis. J Biol Chem. 2004 Feb 06; 279(6):4862-8. Boudreau NJ, Varner JA. PMID: 14610084.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    43. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003 Jul; 112(1):30-41. Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. PMID: 12840057; PMCID: PMC162283.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    44. Inhibition of endothelial cell survival and angiogenesis by protein kinase A. J Clin Invest. 2002 Oct; 110(7):933-41. Kim S, Bakre M, Yin H, Varner JA. PMID: 12370271; PMCID: PMC151143.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    45. Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Res. 2002 Jul 15; 62(14):4007-14. Ojo-Amaize EA, Nchekwube EJ, Cottam HB, Bai R, Verdier-Pinard P, Kakkanaiah VN, Varner JA, Leoni L, Okogun JI, Adesomoju AA, Oyemade OA, Hamel E. PMID: 12124334.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    46. Inhibition of angiogenesis and tumor growth by SCH221153, a dual alpha(v)beta3 and alpha(v)beta5 integrin receptor antagonist. Cancer Res. 2001 Mar 01; 61(5):2232-8. Kumar CC, Malkowski M, Yin Z, Tanghetti E, Yaremko B, Nechuta T, Varner J, Liu M, Smith EM, Neustadt B, Presta M, Armstrong L. PMID: 11280792.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    47. Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem. 2000 Oct 27; 275(43):33920-8. Kim S, Harris M, Varner JA. PMID: 10944524.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    48. A mathematical model of caspase function in apoptosis. Nat Biotechnol. 2000 Jul; 18(7):768-74. Fussenegger M, Bailey JE, Varner J. PMID: 10888847.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    49. Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. Am J Pathol. 2000 Apr; 156(4):1345-62. Kim S, Bell K, Mousa SA, Varner JA. PMID: 10751360; PMCID: PMC1876892.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    50. Targeting integrins alpha v beta 3 and alpha v beta 5 for blocking tumor-induced angiogenesis. Adv Exp Med Biol. 2000; 476:169-80. Kumar CC, Armstrong L, Yin Z, Malkowski M, Maxwell E, Ling H, Yaremko B, Liu M, Varner J, Smith EM, Neustadt B, Nechuta T. PMID: 10949664.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    51. Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. J Biol Chem. 1999 Apr 16; 274(16):11101-9. Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T. PMID: 10196194.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    52. Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro). Angiogenesis. 1999; 3(1):53-60. Varner JA, Nakada MT, Jordan RE, Coller BS. PMID: 14517444.
      View in: PubMed   Mentions: 18     Fields:    
    53. The role of vascular cell integrins alpha v beta 3 and alpha v beta 5 in angiogenesis. EXS. 1997; 79:361-90. Varner JA. PMID: 9002227.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    54. Integrins and cancer. Curr Opin Cell Biol. 1996 Oct; 8(5):724-30. Varner JA, Cheresh DA. PMID: 8939661.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    55. Isolation of a sponge-derived extracellular matrix adhesion protein. J Biol Chem. 1996 Jul 05; 271(27):16119-25. Varner JA. PMID: 8663195.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    56. Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol. 1996; 69-87. Varner JA, Cheresh DA. PMID: 8791129.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    57. Definition of two angiogenic pathways by distinct alpha v integrins. Science. 1995 Dec 01; 270(5241):1500-2. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA. PMID: 7491498.
      View in: PubMed   Mentions: 300     Fields:    Translation:Animals
    58. REVIEW: the integrin alpha V beta 3: angiogenesis and apoptosis. Cell Adhes Commun. 1995 Nov; 3(4):367-74. Varner JA, Brooks PC, Cheresh DA. PMID: 8821037.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    59. Cell adhesion in sponges: potentiation by a cell surface 68 kDa proteoglycan-binding protein. J Cell Sci. 1995 Sep; 108 ( Pt 9):3119-26. Varner JA. PMID: 8537451.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    60. Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol Biol Cell. 1995 Jun; 6(6):725-40. Varner JA, Emerson DA, Juliano RL. PMID: 7579691; PMCID: PMC301232.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    61. Adhesion molecules in cancer: the role of integrins. Curr Opin Cell Biol. 1993 Oct; 5(5):812-8. Juliano RL, Varner JA. PMID: 8240825.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    62. Functional role of the cytoplasmic domain of the integrin alpha 5 subunit. J Cell Biol. 1993 Jul; 122(1):209-21. Bauer JS, Varner J, Schreiner C, Kornberg L, Nicholas R, Juliano RL. PMID: 7686163; PMCID: PMC2119610.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    63. A serum heterodimer from hagfish (Eptatretus stoutii) exhibits structural similarity and partial sequence identity with immunoglobulin. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):1746-50. Varner J, Neame P, Litman GW. PMID: 2000382; PMCID: PMC51101.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    64. Evolutionary development of immunoglobulin gene diversity. Adv Exp Med Biol. 1991; 292:11-7. Litman GW, Amemiya CT, Harding FA, Haire RN, Hinds KR, Litman RT, Ohta Y, Shamblott MJ, Varner JA. PMID: 1950762.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    65. Two cell surface proteins bind the sponge Microciona prolifera aggregation factor. J Biol Chem. 1988 Jun 15; 263(17):8498-508. Varner JA, Burger MM, Kaufman JF. PMID: 3372540.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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