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    Joan Heller Brown

    TitleDistinguished Professor and Department Chair
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0636
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      Ph.D.Albert Einstein College of Medicine

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      RhoA and GPCR mediated transcriptional activation regulates glioblastoma
      NIH/NCI R01CA218859Feb 9, 2018 - Jan 31, 2023
      Role: Principal Investigator
      Restoring Mycocardial Healing
      NIH P01HL085577Jul 1, 2006 - Jul 31, 2018
      Role: Co-Investigator
      NIH/NHLBI R01HL061505Sep 30, 1998 - Aug 31, 2003
      Role: Principal Investigator
      Molecular Pathways for Hypertrophy and Cardiomyopathy
      NIH/NHLBI P01HL046345Feb 1, 1992 - Jun 30, 2014
      Role: Co-Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      RhoA mediated survival signals in cardiomyocytes
      NIH/NHLBI R37HL028143Aug 1, 1982 - Jan 31, 2020
      Role: Principal Investigator
      Rho- and GPCR-mediated signaling through novel cellular effectors
      NIH/NIGMS R01GM036927Aug 1, 1982 - Aug 31, 2013
      Role: Principal Investigator
      S1P, Rho and Akt signaling in cardiomyocyte survival
      NIH/NHLBI R01HL028143Aug 1, 1982 - Mar 31, 2010
      Role: Principal Investigator
      Rho- and GPCR-mediated signaling through novel cellular effectors
      NIH/NIGMS R56GM036927Aug 1, 1982 - Aug 31, 2009
      Role: Principal Investigator
      Graduate Training in Cellular and Molecular Pharmacology
      NIH/NIGMS T32GM007752Jul 1, 1979 - Jun 30, 2019
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Dusaban SS, Chun J, Rosen H, Purcell NH, Brown J. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. J Neuroinflammation. 2017 Jun 02; 14(1):111. PMID: 28577576.
        View in: PubMed
      2. Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown J. CaMKIId subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-?B and TNF-a. J Mol Cell Cardiol. 2017 Feb; 103:48-55. PMID: 28077321.
        View in: PubMed
      3. Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown J, Miyamoto S. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol. 2017 Feb; 103:1-10. PMID: 28017639.
        View in: PubMed
      4. Høydal MA, Stølen TO, Kettlewell S, Maier LS, Brown J, Sowa T, Catalucci D, Condorelli G, Kemi OJ, Smith GL, Wisløff U. Exercise training reverses myocardial dysfunction induced by CaMKIIdC overexpression by restoring Ca2+ homeostasis. J Appl Physiol (1985). 2016 Jul 01; 121(1):212-20. PMID: 27231311; PMCID: PMC4967256 [Available on 07/01/17].
      5. Castaldi A, Chesini GP, Taylor AE, Sussman MA, Brown J, Purcell NH. Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. Cell Signal. 2016 08; 28(8):871-9. PMID: 27094722; PMCID: PMC5004781 [Available on 08/01/17].
      6. Miyamoto S, Brown J. Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload. Circulation. 2016 Mar 29; 133(13):1225-7. PMID: 26915632.
        View in: PubMed
      7. Panama BK, Korogyi AS, Aschar-Sobbi R, Oh Y, Gray CB, Gang H, Brown J, Kirshenbaum LA, Backx PH. Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic ß-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor ?B. J Biol Chem. 2016 Feb 19; 291(8):4156-65. PMID: 26742842; PMCID: PMC4759190 [Available on 02/19/17].
      8. Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown J, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ. Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Mol Pharmacol. 2016 Jan; 89(1):176-86. PMID: 26494861; PMCID: PMC4702096 [Available on 01/01/17].
      9. Yu OM, Miyamoto S, Brown J. Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation. Mol Cell Biol. 2016 Jan 01; 36(1):39-49. PMID: 26459764; PMCID: PMC4702594.
      10. Dusaban SS, Kunkel MT, Smrcka AV, Brown J. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C?. J Biol Chem. 2015 Oct 30; 290(44):26776-83. PMID: 26350460; PMCID: PMC4646330 [Available on 10/30/16].
      11. Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown J. CaMKIId mediates ß-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ß-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91. PMID: 26080362; PMCID: PMC4530053.
      12. Brown J, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. The First 50 Years of Molecular Pharmacology. Mol Pharmacol. 2015 Jul; 88(1):139-40. PMID: 25943115.
        View in: PubMed
      13. Yu OM, Brown J. G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation. Mol Pharmacol. 2015 Jul; 88(1):171-80. PMID: 25904553; PMCID: PMC4468647.
      14. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. PMID: 25605649; PMCID: PMC4344921.
      15. van Oort RJ, Brown J, Westenbrink BD. CaMKII confirms its promise in ischaemic heart disease. Eur J Heart Fail. 2014 Dec; 16(12):1268-9. PMID: 25452163.
        View in: PubMed
      16. Dusaban SS, Brown J. PLCe mediated sustained signaling pathways. Adv Biol Regul. 2015 Jan; 57:17-23. PMID: 25453218; PMCID: PMC4314097.
      17. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. PMID: 25236710; PMCID: PMC4301603.
      18. Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown J, Miyamoto S. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. J Mol Cell Cardiol. 2014 Oct; 75:152-61. PMID: 25106095; PMCID: PMC4157956.
      19. Di Carlo MN, Said M, Ling H, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Skapura DG, Rinaldi G, Respress JL, Brown J, Wehrens XH, Salas MA, Mattiazzi A. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83. PMID: 24949568; PMCID: PMC4131282.
      20. Suarez J, Wang H, Scott BT, Ling H, Makino A, Swanson E, Brown J, Suarez JA, Feinstein S, Diaz-Juarez J, Dillmann WH. In vivo selective expression of thyroid hormone receptor a1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 01; 307(3):R340-6. PMID: 24848360; PMCID: PMC4121632.
      21. Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown J. The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem. 2014 Jun 20; 289(25):17689-98. PMID: 24790104; PMCID: PMC4067203.
      22. Gray CB, Heller Brown J. CaMKIIdelta subtypes: localization and function. Front Pharmacol. 2014; 5:15. PMID: 24575042; PMCID: PMC3920101.
      23. Benincá C, Planagumà J, de Freitas Shuck A, Acín-Perez R, Muñoz JP, de Almeida MM, Brown J, Murphy AN, Zorzano A, Enríquez JA, Aragay AM. A new non-canonical pathway of Ga(q) protein regulating mitochondrial dynamics and bioenergetics. Cell Signal. 2014 May; 26(5):1135-46. PMID: 24444709; PMCID: PMC4745894.
      24. Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J. PLCe, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal. 2013 Dec 17; 6(306):ra108. PMID: 24345679; PMCID: PMC4035240.
      25. Zhang DM, Chai Y, Erickson JR, Brown J, Bers DM, Lin YF. Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J Physiol. 2014 Mar 01; 592(5):971-90. PMID: 24277866; PMCID: PMC3948558.
      26. Westenbrink BD, Edwards AG, McCulloch AD, Brown J. The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias. Expert Opin Ther Targets. 2013 Aug; 17(8):889-903. PMID: 23789646.
        View in: PubMed
      27. Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown J. Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3609-14. PMID: 23401561; PMCID: PMC3587233.
      28. Ling H, Gray CB, Zambon AC, Grimm M, Gu Y, Dalton N, Purcell NH, Peterson K, Brown J. Ca2+/Calmodulin-dependent protein kinase II d mediates myocardial ischemia/reperfusion injury through nuclear factor-?B. Circ Res. 2013 Mar 15; 112(6):935-44. PMID: 23388157; PMCID: PMC3673710.
      29. Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown J, Wehrens XH, Chen J, Bers DM. Epac2 mediates cardiac ß1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22. PMID: 23363625; PMCID: PMC3690126.
      30. Chen B, Van Winkle JA, Lyden PD, Brown J, Purcell NH. PHLPP1 gene deletion protects the brain from ischemic injury. J Cereb Blood Flow Metab. 2013 Feb; 33(2):196-204. PMID: 23072745; PMCID: PMC3564187.
      31. Xiang SY, Dusaban SS, Brown J. Lysophospholipid receptor activation of RhoA and lipid signaling pathways. Biochim Biophys Acta. 2013 Jan; 1831(1):213-22. PMID: 22986288; PMCID: PMC4076288.
      32. Mo JS, Yu FX, Gong R, Brown J, Guan KL. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev. 2012 Oct 01; 26(19):2138-43. PMID: 22972936; PMCID: PMC3465735.
      33. Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown J, Ruiz-Lozano P. APJ acts as a dual receptor in cardiac hypertrophy. Nature. 2012 Aug 16; 488(7411):394-8. PMID: 22810587; PMCID: PMC3422434.
      34. Ortiz-Sanchez JM, Nichols SE, Sayyah J, Brown J, McCammon JA, Grant BJ. Identification of potential small molecule binding pockets on Rho family GTPases. PLoS One. 2012; 7(7):e40809. PMID: 22815826; PMCID: PMC3397943.
      35. Guo T, Zhang T, Ginsburg KS, Mishra S, Brown J, Bers DM. CaMKIIdC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks. Biophys J. 2012 Jun 06; 102(11):2461-70. PMID: 22713561; PMCID: PMC3368151.
      36. Smrcka AV, Brown J, Holz GG. Role of phospholipase Ce in physiological phosphoinositide signaling networks. Cell Signal. 2012 Jun; 24(6):1333-43. PMID: 22286105; PMCID: PMC3325758.
      37. Grant BJ, Lukman S, Hocker HJ, Sayyah J, Brown J, McCammon JA, Gorfe AA. Novel allosteric sites on Ras for lead generation. PLoS One. 2011; 6(10):e25711. PMID: 22046245; PMCID: PMC3201956.
      38. Mishra S, Gray CB, Miyamoto S, Bers DM, Brown J. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011 Dec 09; 109(12):1354-62. PMID: 21998325; PMCID: PMC3241507.
      39. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown J. RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest. 2011 Aug; 121(8):3269-76. PMID: 21747165; PMCID: PMC3148727.
      40. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown J, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 2011 Jul 08; 109(2):141-50. PMID: 21597010; PMCID: PMC3132348.
      41. Grimm M, Ling H, Brown J. Crossing signals: relationships between ß-adrenergic stimulation and CaMKII activation. Heart Rhythm. 2011 Aug; 8(8):1296-8. PMID: 21354330; PMCID: PMC3153445.
      42. Anderson ME, Brown J, Bers DM. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):468-73. PMID: 21276796; PMCID: PMC3158288.
      43. Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown J, Kockskämper J, Priori SG, Pieske B, Maier LS. Overexpression of CaMKIIdc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality. J Am Coll Cardiol. 2011 Jan 25; 57(4):469-79. PMID: 21251589.
        View in: PubMed
      44. Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Eur Heart J. 2011 Sep; 32(17):2179-88. PMID: 21228009; PMCID: PMC3164102.
      45. Mishra S, Ling H, Grimm M, Zhang T, Bers DM, Brown J. Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. J Cardiovasc Pharmacol. 2010 Dec; 56(6):598-603. PMID: 20531218; PMCID: PMC2947575.
      46. Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown J, Dedman JR, Bers DM. SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIdC. J Mol Cell Cardiol. 2011 Jan; 50(1):230-8. PMID: 20971119; PMCID: PMC3018844.
      47. Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown J, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 2010 Oct; 120(10):3680-7. PMID: 20890047; PMCID: PMC2947235.
      48. Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown J, Chen J, Sonenberg N, Condorelli G. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16. PMID: 20644257; PMCID: PMC2912201.
      49. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown J. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. PMID: 20576936; PMCID: PMC2957297.
      50. Miyamoto S, Del Re DP, Xiang SY, Zhao X, Florholmen G, Brown J. Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res. 2010 Aug; 3(4):330-43. PMID: 20559774; PMCID: PMC3005405.
      51. Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown J, Sussman MA. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010 Apr 16; 106(7):1265-74. PMID: 20203306; PMCID: PMC2864233.
      52. Carretero-Ortega J, Walsh CT, Hernández-García R, Reyes-Cruz G, Brown J, Vázquez-Prado J. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. Mol Pharmacol. 2010 Mar; 77(3):435-42. PMID: 20018810; PMCID: PMC3202486.
      53. Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown J. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010 Feb 05; 106(2):354-62. PMID: 19959778; PMCID: PMC2818826.
      54. Mani SK, Egan EA, Addy BK, Grimm M, Kasiganesan H, Thiyagarajan T, Renaud L, Brown J, Kern CB, Menick DR. beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J Mol Cell Cardiol. 2010 Feb; 48(2):342-51. PMID: 19945464; PMCID: PMC3624970.
      55. Grimm M, Brown J. Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol. 2010 Feb; 48(2):322-30. PMID: 19883653; PMCID: PMC2896283.
      56. Catalucci D, Latronico MV, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown J, Condorelli G. Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17. J Biol Chem. 2009 Oct 09; 284(41):28180-7. PMID: 19696029; PMCID: PMC2788869.
      57. Sag CM, Wadsack DP, Khabbazzadeh S, Abesser M, Grefe C, Neumann K, Opiela MK, Backs J, Olson EN, Brown J, Neef S, Maier SK, Maier LS. Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail. 2009 Nov; 2(6):664-75. PMID: 19919992; PMCID: PMC2835502.
      58. MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown J, Sabri AK, Molkentin JD, Houser SR. CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circ Res. 2009 Aug 14; 105(4):316-25. PMID: 19608982; PMCID: PMC2765687.
      59. Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH, Heller Brown J. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009 May; 119(5):1230-40. PMID: 19381018; PMCID: PMC2673879.
      60. Miyamoto S, Murphy AN, Brown J. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009 Apr; 41(2):169-80. PMID: 19377835; PMCID: PMC2732429.
      61. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown J, Condorelli G. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol. 2009 Mar 23; 184(6):923-33. PMID: 19307602; PMCID: PMC2699149.
      62. Karliner JS, Brown J. Lipid signalling in cardiovascular pathophysiology. Cardiovasc Res. 2009 May 01; 82(2):171-4. PMID: 19297369.
        View in: PubMed
      63. Means CK, Brown J. Sphingosine-1-phosphate receptor signalling in the heart. Cardiovasc Res. 2009 May 01; 82(2):193-200. PMID: 19282351; PMCID: PMC2721649.
      64. Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown J, Sussman MA. Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. J Mol Cell Cardiol. 2009 Jul; 47(1):96-103. PMID: 19269295; PMCID: PMC2692628.
      65. Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown J, Molkentin JD, Kranias EG, Dorn GW. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. J Clin Invest. 2009 Jan; 119(1):203-12. PMID: 19065046.
        View in: PubMed
      66. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. PMID: 19033658; PMCID: PMC2575833.
      67. Del Re DP, Miyamoto S, Brown J. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem. 2008 Dec 19; 283(51):35622-9. PMID: 18854312; PMCID: PMC2602897.
      68. Walsh CT, Radeff-Huang J, Matteo R, Hsiao A, Subramaniam S, Stupack D, Brown J. Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61. FASEB J. 2008 Nov; 22(11):4011-21. PMID: 18687805; PMCID: PMC3980657.
      69. Walsh CT, Stupack D, Brown J. G protein-coupled receptors go extracellular: RhoA integrates the integrins. Mol Interv. 2008 Aug; 8(4):165-73. PMID: 18829842; PMCID: PMC2637220.
      70. Haga JH, Kaunas R, Radeff-Huang J, Weems JM, Estrada KD, Chien S, Brown J, Seasholtz TM. Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008 Jul 18; 372(1):216-20. PMID: 18474218; PMCID: PMC2587448.
      71. Means CK, Miyamoto S, Chun J, Brown J. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem. 2008 May 02; 283(18):11954-63. PMID: 18296752; PMCID: PMC2335351.
      72. Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W, Dybkova N, Chang S, Ling H, Bers DM, Maier LS, Olson EN, Brown J. CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem. 2007 Nov 30; 282(48):35078-87. PMID: 17923476.
        View in: PubMed
      73. Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV, Brown J. Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15543-8. PMID: 17878312; PMCID: PMC2000505.
      74. Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown J. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2944-51. PMID: 17293497.
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      75. Del Re DP, Miyamoto S, Brown J. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem. 2007 Mar 16; 282(11):8069-78. PMID: 17234627.
        View in: PubMed
      76. Maier LS, Bers DM, Brown J. Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology. Cardiovasc Res. 2007 Mar 01; 73(4):629-30. PMID: 17258179.
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      77. Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown J, Bers DM, Maier LS. Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest. 2006 Dec; 116(12):3127-38. PMID: 17124532; PMCID: PMC1654201.
      78. Radeff-Huang J, Seasholtz TM, Chang JW, Smith JM, Walsh CT, Brown J. Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. J Biol Chem. 2007 Jan 12; 282(2):863-70. PMID: 17114809.
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      79. Seasholtz TM, Wessel J, Rao F, Rana BK, Khandrika S, Kennedy BP, Lillie EO, Ziegler MG, Smith DW, Schork NJ, Brown J, O'Connor DT. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity. Hypertension. 2006 May; 47(5):937-47. PMID: 16585408.
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