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Jerold Chun

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #
La Jolla CA 92093
Phone858-784-8410
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    Collapse Research 
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    Prenatal blood-borne lipids in post-hemorrhagic hydrocephalus
    NIH/NINDS R01NS084398Jul 1, 2014 - Jun 30, 2018
    Role: Principal Investigator
    Mechanisms and consequences of CNS aneuploidies altered by fetal ethanol exposure
    NIH/NIAAA R01AA021402Jul 15, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Lysophospholipid mechanisms in congenital hydrocephalus
    NIH/NINDS R56NS082092Sep 30, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Targeting S1P receptors to prevent hearing loss
    NIH/NIDCD R21DC009505Feb 18, 2009 - Jan 31, 2011
    Role: Principal Investigator
    Receptor-mediated S1P signaling in the embryonic brain
    NIH/NIDA R01DA019674Aug 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Interactions of LPA and prostaglandins in implantation
    NIH/NICHD R01HD050685May 1, 2006 - Feb 28, 2011
    Role: Principal Investigator
    Functional studies on normal neural aneuploidy
    NIH/NIMH R21MH076145Dec 15, 2005 - Nov 30, 2007
    Role: Principal Investigator
    Lysophospholipids roles for Schwann cell &myelination
    NIH/NINDS R01NS048478Sep 15, 2004 - Apr 30, 2010
    Role: Principal Investigator
    ROLES FOR LPA SIGNALING IN CEREBRAL CORTICAL DEVELOPMENT
    NIH/NIMH K02MH001723Aug 1, 1999 - Jul 31, 2007
    Role: Principal Investigator
    EMBRYONIC CORTICAL APOPTOSIS ROLES AND REGULATIONS
    NIH/NINDS R01NS036949Jul 8, 1998 - Jun 30, 2002
    Role: Principal Investigator
    7-TRANSMEMBRANE RECEPTOR CONTROL OF CORTEX NEUROGENESIS
    NIH/NIMH R01MH056158Apr 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    Receptor-mediated LPA signaling in cortical development
    NIH/NIMH R01MH051699May 1, 1994 - Mar 31, 2010
    Role: Principal Investigator
    CELL LINES FOR FINDING DEVELOPMENTAL NEOCORTICAL GENES
    NIH/NIMH R29MH051699May 1, 1994 - Apr 30, 1999
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lake BB, Chen S, Sos BC, Fan J, Kaeser GE, Yung YC, Duong TE, Gao D, Chun J, Kharchenko PV, Zhang K. Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. Nat Biotechnol. 2018 Jan; 36(1):70-80. PMID: 29227469.
      View in: PubMed
    2. Lake BB, Codeluppi S, Yung YC, Gao D, Chun J, Kharchenko PV, Linnarsson S, Zhang K. A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA. Sci Rep. 2017 Jul 20; 7(1):6031. PMID: 28729663.
      View in: PubMed
    3. Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. J Neuroinflammation. 2017 Jun 02; 14(1):111. PMID: 28577576.
      View in: PubMed
    4. Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol. 2017 02; 103:1-10. PMID: 28017639.
      View in: PubMed
    5. Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. Science. 2016 Jun 24; 352(6293):1586-90. PMID: 27339989; PMCID: PMC5038589.
    6. Stoddard NC, Chun J. Promising pharmacological directions in the world of lysophosphatidic Acid signaling. Biomol Ther (Seoul). 2015 Jan; 23(1):1-11. PMID: 25593637; PMCID: PMC4286743.
    7. Gole J, Gore A, Richards A, Chiu YJ, Fung HL, Bushman D, Chiang HI, Chun J, Lo YH, Zhang K. Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells. Nat Biotechnol. 2013 Dec; 31(12):1126-32. PMID: 24213699; PMCID: PMC3875318.
    8. Means CK, Miyamoto S, Chun J, Brown JH. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem. 2008 May 02; 283(18):11954-63. PMID: 18296752; PMCID: PMC2335351.
    9. Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown JH. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2944-51. PMID: 17293497.
      View in: PubMed
    10. Chao C, Herr D, Chun J, Xu Y. Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J. 2006 Jun 07; 25(11):2615-22. PMID: 16757976; PMCID: PMC1478190.
    11. Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J. Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J Neurosci. 2003 Nov 12; 23(32):10454-62. PMID: 14614104.
      View in: PubMed
    12. Kaushal D, Contos JJ, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J. Alteration of gene expression by chromosome loss in the postnatal mouse brain. J Neurosci. 2003 Jul 02; 23(13):5599-606. PMID: 12843262.
      View in: PubMed
    13. Ye X, Ishii I, Kingsbury MA, Chun J. Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):108-13. PMID: 12531543.
      View in: PubMed
    14. Ye X, Fukushima N, Kingsbury MA, Chun J. Lysophosphatidic acid in neural signaling. Neuroreport. 2002 Dec 03; 13(17):2169-75. PMID: 12488791.
      View in: PubMed
    15. McGiffert C, Contos JJ, Friedman B, Chun J. Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. FEBS Lett. 2002 Oct 30; 531(1):103-8. PMID: 12401212.
      View in: PubMed
    16. Contos JJ, Ye X, Sah VP, Chun J. Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene. FEBS Lett. 2002 Oct 30; 531(1):99-102. PMID: 12401211.
      View in: PubMed
    17. Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol. 2002 Oct; 22(19):6921-9. PMID: 12215548; PMCID: PMC134025.
    18. Fukushima N, Weiner JA, Kaushal D, Contos JJ, Rehen SK, Kingsbury MA, Kim KY, Chun J. Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol Cell Neurosci. 2002 Jun; 20(2):271-82. PMID: 12093159.
      View in: PubMed
    19. Yang AH, Ishii I, Chun J. In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim Biophys Acta. 2002 May 23; 1582(1-3):197-203. PMID: 12069829.
      View in: PubMed
    20. Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem. 2002 Jul 12; 277(28):25152-9. PMID: 12006579.
      View in: PubMed
    21. Chun J, Weiner JA, Fukushima N, Contos JJ, Zhang G, Kimura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D. Neurobiology of receptor-mediated lysophospholipid signaling. From the first lysophospholipid receptor to roles in nervous system function and development. Ann N Y Acad Sci. 2000 Apr; 905:110-7. PMID: 10818447.
      View in: PubMed
    22. Chun J. Developmental neurobiology: a genetic Cheshire cat? Curr Biol. 1999 Sep 09; 9(17):R651-4. PMID: 10508574.
      View in: PubMed
    23. Chun J, Schatz DG. Developmental neurobiology: Alternative ends for a familiar story? Curr Biol. 1999 Apr 08; 9(7):R251-3. PMID: 10209111.
      View in: PubMed
    24. Chun J, Contos JJ, Munroe D. A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem Biophys. 1999; 30(2):213-42. PMID: 10356643.
      View in: PubMed
    25. Chun J, Schatz DG. Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins. Neuron. 1999 Jan; 22(1):7-10. PMID: 10027282.
      View in: PubMed
    26. Chun J, Jaenisch R. Clonal cell lines produced by infection of neocortical neuroblasts using multiple oncogenes transduced by retroviruses. Mol Cell Neurosci. 1996 Apr; 7(4):304-21. PMID: 8793865.
      View in: PubMed