Jerold Chun

Title(s)Adjunct Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-3964-092 Additional info
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    New Down syndrome brain organization revealed by single-cell genomics
    NIH R56AG073965Sep 15, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Transformative research on somatic gene recombination in the normal and Alzheimer's disease-related dementia brain
    NIH R01AG071465Sep 11, 2020 - May 31, 2025
    Role: Principal Investigator
    Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains
    NIH R01AG065541Apr 1, 2020 - Jan 31, 2025
    Role: Principal Investigator
    Transformative research on the normal and Alzheimer's disease brain through studies of neuronal gene recombination
    NIH R56AG067489Sep 1, 2019 - Aug 31, 2020
    Role: Principal Investigator
    Toward a human adult brain cell atlas with single-cell technologies
    NIH U01MH114828Aug 22, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Prenatal blood-borne lipids in post-hemorrhagic hydrocephalus
    NIH R01NS084398Jul 1, 2014 - Aug 31, 2018
    Role: Principal Investigator
    Mechanisms and consequences of CNS aneuploidies altered by fetal ethanol exposure
    NIH R01AA021402Jul 15, 2013 - Sep 30, 2018
    Role: Principal Investigator
    Lysophospholipid mechanisms in congenital hydrocephalus
    NIH R56NS082092Sep 30, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Targeting S1P receptors to prevent hearing loss
    NIH R21DC009505Feb 18, 2009 - Jan 31, 2011
    Role: Principal Investigator
    Receptor-mediated S1P signaling in the embryonic brain
    NIH R01DA019674Aug 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Interactions of LPA and prostaglandins in implantation
    NIH R01HD050685May 1, 2006 - Feb 28, 2011
    Role: Principal Investigator
    Functional studies on normal neural aneuploidy
    NIH R21MH076145Dec 15, 2005 - Nov 30, 2007
    Role: Principal Investigator
    Lysophospholipids roles for Schwann cell &myelination
    NIH R01NS048478Sep 15, 2004 - Apr 30, 2010
    Role: Principal Investigator
    ROLES FOR LPA SIGNALING IN CEREBRAL CORTICAL DEVELOPMENT
    NIH K02MH001723Aug 1, 1999 - Jul 31, 2007
    Role: Principal Investigator
    EMBRYONIC CORTICAL APOPTOSIS ROLES AND REGULATIONS
    NIH R01NS036949Jul 8, 1998 - Jun 30, 2002
    Role: Principal Investigator
    7-TRANSMEMBRANE RECEPTOR CONTROL OF CORTEX NEUROGENESIS
    NIH R01MH056158Apr 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    Receptor-mediated LPA signaling in cortical development
    NIH R01MH051699May 1, 1994 - Mar 31, 2010
    Role: Principal Investigator
    CELL LINES FOR FINDING DEVELOPMENTAL NEOCORTICAL GENES
    NIH R29MH051699May 1, 1994 - Apr 30, 1999
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH P50AG005131Sep 28, 1984 - Mar 31, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human brain small extracellular vesicles contain selectively packaged, full-length mRNA. Cell Rep. 2024 Apr 04; 43(4):114061. Ransom LS, Liu CS, Dunsmore E, Palmer CR, Nicodemus J, Ziomek D, Williams N, Chun J. PMID: 38578831.
      View in: PubMed   Mentions:    Fields:    
    2. Mapping human tissues with highly multiplexed RNA in situ hybridization. Nat Commun. 2024 Mar 20; 15(1):2511. Kalhor K, Chen CJ, Lee HS, Cai M, Nafisi M, Que R, Palmer CR, Yuan Y, Zhang Y, Li X, Song J, Knoten A, Lake BB, Gaut JP, Keene CD, Lein E, Kharchenko PV, Chun J, Jain S, Fan JB, Zhang K. PMID: 38509069; PMCID: PMC10954689.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Mapping Human Tissues with Highly Multiplexed RNA in situ Hybridization. bioRxiv. 2023 Aug 19. Kalhor K, Chen CJ, Lee HS, Cai M, Nafisi M, Que R, Palmer C, Yuan Y, Zhang Y, Song J, Knoten A, Lake BB, Gaut JP, Keene D, Lein E, Kharchenko PV, Chun J, Jain S, Fan JB, Zhang K. PMID: 37645998; PMCID: PMC10462101.
      View in: PubMed   Mentions:
    4. Genomic mosaicism in the developing and adult brain. Dev Neurobiol. 2018 11; 78(11):1026-1048. Rohrback S, Siddoway B, Liu CS, Chun J. PMID: 30027562; PMCID: PMC6214721.
      View in: PubMed   Mentions: 48     Fields:    
    5. Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. Nat Biotechnol. 2018 01; 36(1):70-80. Lake BB, Chen S, Sos BC, Fan J, Kaeser GE, Yung YC, Duong TE, Gao D, Chun J, Kharchenko PV, Zhang K. PMID: 29227469; PMCID: PMC5951394.
      View in: PubMed   Mentions: 410     Fields:    Translation:HumansCells
    6. A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA. Sci Rep. 2017 07 20; 7(1):6031. Lake BB, Codeluppi S, Yung YC, Gao D, Chun J, Kharchenko PV, Linnarsson S, Zhang K. PMID: 28729663; PMCID: PMC5519641.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    7. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. J Neuroinflammation. 2017 06 02; 14(1):111. Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH. PMID: 28577576; PMCID: PMC5455202.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    8. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol. 2017 02; 103:1-10. Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S. PMID: 28017639; PMCID: PMC5410967.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    9. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. Science. 2016 Jun 24; 352(6293):1586-90. Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K. PMID: 27339989; PMCID: PMC5038589.
      View in: PubMed   Mentions: 422     Fields:    Translation:HumansCells
    10. Promising pharmacological directions in the world of lysophosphatidic Acid signaling. Biomol Ther (Seoul). 2015 Jan; 23(1):1-11. Stoddard NC, Chun J. PMID: 25593637; PMCID: PMC4286743.
      View in: PubMed   Mentions: 42  
    11. Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells. Nat Biotechnol. 2013 Dec; 31(12):1126-32. Gole J, Gore A, Richards A, Chiu YJ, Fung HL, Bushman D, Chiang HI, Chun J, Lo YH, Zhang K. PMID: 24213699; PMCID: PMC3875318.
      View in: PubMed   Mentions: 102     Fields:    
    12. Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain. J Biol Chem. 2012 May 18; 287(21):17608-17617. Lin ME, Rivera RR, Chun J. PMID: 22461625; PMCID: PMC3366844.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    13. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem. 2008 May 02; 283(18):11954-63. Means CK, Miyamoto S, Chun J, Brown JH. PMID: 18296752; PMCID: PMC2335351.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    14. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2944-51. Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown JH. PMID: 17293497.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    15. Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J. 2006 Jun 07; 25(11):2615-22. Chao C, Herr D, Chun J, Xu Y. PMID: 16757976; PMCID: PMC1478190.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    16. Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J Neurosci. 2003 Nov 12; 23(32):10454-62. Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J. PMID: 14614104; PMCID: PMC6740997.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    17. Alteration of gene expression by chromosome loss in the postnatal mouse brain. J Neurosci. 2003 Jul 02; 23(13):5599-606. Kaushal D, Contos JJ, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J. PMID: 12843262; PMCID: PMC6741244.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    18. Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):108-13. Ye X, Ishii I, Kingsbury MA, Chun J. PMID: 12531543.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    19. Lysophosphatidic acid in neural signaling. Neuroreport. 2002 Dec 03; 13(17):2169-75. Ye X, Fukushima N, Kingsbury MA, Chun J. PMID: 12488791.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    20. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol. 2002 Oct; 22(19):6921-9. Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. PMID: 12215548; PMCID: PMC134025.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    21. Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol Cell Neurosci. 2002 Jun; 20(2):271-82. Fukushima N, Weiner JA, Kaushal D, Contos JJ, Rehen SK, Kingsbury MA, Kim KY, Chun J. PMID: 12093159.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    22. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem. 2002 Jul 12; 277(28):25152-9. Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J. PMID: 12006579.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    23. Neurobiology of receptor-mediated lysophospholipid signaling. From the first lysophospholipid receptor to roles in nervous system function and development. Ann N Y Acad Sci. 2000 Apr; 905:110-7. Chun J, Weiner JA, Fukushima N, Contos JJ, Zhang G, Kimura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D. PMID: 10818447.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    24. Developmental neurobiology: a genetic Cheshire cat? Curr Biol. 1999 Sep 09; 9(17):R651-4. Chun J. PMID: 10508574.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Developmental neurobiology: Alternative ends for a familiar story? Curr Biol. 1999 Apr 08; 9(7):R251-3. Chun J, Schatz DG. PMID: 10209111.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    26. A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem Biophys. 1999; 30(2):213-42. Chun J, Contos JJ, Munroe D. PMID: 10356643.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins. Neuron. 1999 Jan; 22(1):7-10. Chun J, Schatz DG. PMID: 10027282.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. Clonal cell lines produced by infection of neocortical neuroblasts using multiple oncogenes transduced by retroviruses. Mol Cell Neurosci. 1996 Apr; 7(4):304-21. Chun J, Jaenisch R. PMID: 8793865.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    29. V(D)J recombination and the transgenic brain blues. New Biol. 1992 Mar; 4(3):188-96. Schatz DG, Chun JJ. PMID: 1581289.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science. 1991 Aug 16; 253(5021):778-81. Turka LA, Schatz DG, Oettinger MA, Chun JJ, Gorka C, Lee K, McCormack WT, Thompson CB. PMID: 1831564.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    31. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell. 1991 Jan 11; 64(1):189-200. Chun JJ, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D. PMID: 1986864.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    32. The earliest-generated neurons of the cat cerebral cortex: characterization by MAP2 and neurotransmitter immunohistochemistry during fetal life. J Neurosci. 1989 May; 9(5):1648-67. Chun JJ, Shatz CJ. PMID: 2566660; PMCID: PMC6569841.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    33. Redistribution of synaptic vesicle antigens is correlated with the disappearance of a transient synaptic zone in the developing cerebral cortex. Neuron. 1988 Jun; 1(4):297-310. Chun JJ, Shatz CJ. PMID: 3152420.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
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