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Kay Tye

Title(s)Adjunct Professor, Neurobiology
SchoolAcademic Aff
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    Collapse Research 
    Collapse Research Activities and Funding
    Exploring neural circuit mechanisms of social contact and social isolation
    NIH/NIMH R01MH115920Jun 26, 2018 - Mar 31, 2023
    Role: Principal Investigator
    2018 Optogenetic Approaches to Understanding Neural Circuits & Behavior GRC
    NIH/NIDA R13DA046191May 1, 2018 - Apr 30, 2019
    Role: Principal Investigator
    Neural Circuit Mechanisms of Social Homeostasis in Individuals and Supraorganismal Social Groups
    NIH/NCCIH DP1AT009925Sep 30, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Examination of neural circuits underlying mood disorders in Alzheimer?s disease
    NIH/NIA RF1AG047661Jul 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Dissecting the Neural Circuits Encoding Positive and Negative Valence
    NIH/NIMH R01MH102441Jan 15, 2014 - Nov 30, 2018
    Role: Principal Investigator
    A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
    NIH/NIDDK DP2DK102256Sep 30, 2013 - Jun 30, 2019
    Role: Principal Investigator
    The effects of thalamoamygdalar synaptic potentiation on learning performance
    NIH/NIMH F32MH088010Sep 25, 2009 - Sep 24, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Padilla-Coreano N, Canetta S, Mikofsky RM, Alway E, Passecker J, Myroshnychenko MV, Garcia-Garcia AL, Warren R, Teboul E, Blackman DR, Morton MP, Hupalo S, Tye KM, Kellendonk C, Kupferschmidt DA, Gordon JA. Hippocampal-Prefrontal Theta Transmission Regulates Avoidance Behavior. Neuron. 2019 Aug 23. PMID: 31521441.
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    2. Mobbs D, Adolphs R, Fanselow MS, Barrett LF, LeDoux JE, Ressler K, Tye KM. Viewpoints: Approaches to defining and investigating fear. Nat Neurosci. 2019 Aug; 22(8):1205-1216. PMID: 31332374.
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    3. Matthews GA, Tye KM. Neural mechanisms of social homeostasis. Ann N Y Acad Sci. 2019 Mar 15. PMID: 30875095.
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    4. Weele CMV, Siciliano CA, Tye KM. Dopamine tunes prefrontal outputs to orchestrate aversive processing. Brain Res. 2019 Jun 15; 1713:16-31. PMID: 30513287.
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    5. Vander Weele CM, Siciliano CA, Matthews GA, Namburi P, Izadmehr EM, Espinel IC, Nieh EH, Schut EHS, Padilla-Coreano N, Burgos-Robles A, Chang CJ, Kimchi EY, Beyeler A, Wichmann R, Wildes CP, Tye KM. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. Nature. 2018 11; 563(7731):397-401. PMID: 30405240.
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    6. Tye KM. Neural Circuit Motifs in Valence Processing. Neuron. 2018 Oct 24; 100(2):436-452. PMID: 30359607.
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    7. Siciliano CA, Mills F, Tye KM. Double threat in striatal dopamine signaling. Nat Neurosci. 2018 10; 21(10):1296-1297. PMID: 30258236.
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    8. Siciliano CA, Tye KM. Leveraging calcium imaging to illuminate circuit dysfunction in addiction. Alcohol. 2019 Feb; 74:47-63. PMID: 30470589.
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    9. Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell. 2018 05 31; 173(6):1329-1342.e18. PMID: 29731170.
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    10. Tye KM, Uchida N. Editorial overview: Neurobiology of behavior. Curr Opin Neurobiol. 2018 04; 49:iv-ix. PMID: 29526385.
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    11. Chatterjee S, Sullivan HA, MacLennan BJ, Xu R, Hou Y, Lavin TK, Lea NE, Michalski JE, Babcock KR, Dietrich S, Matthews GA, Beyeler A, Calhoon GG, Glober G, Whitesell JD, Yao S, Cetin A, Harris JA, Zeng H, Tye KM, Reid RC, Wickersham IR. Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons. Nat Neurosci. 2018 04; 21(4):638-646. PMID: 29507411.
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    12. Beyeler A, Chang CJ, Silvestre M, Lévêque C, Namburi P, Wildes CP, Tye KM. Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala. Cell Rep. 2018 01 23; 22(4):905-918. PMID: 29386133.
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    13. Wang W, Wildes CP, Pattarabanjird T, Sanchez MI, Glober GF, Matthews GA, Tye KM, Ting AY. A light- and calcium-gated transcription factor for imaging and manipulating activated neurons. Nat Biotechnol. 2017 Sep; 35(9):864-871. PMID: 28650461.
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    14. Wei D, Allsop S, Tye K, Piomelli D. Endocannabinoid Signaling in the Control of Social Behavior. Trends Neurosci. 2017 07; 40(7):385-396. PMID: 28554687.
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    15. Burgos-Robles A, Kimchi EY, Izadmehr EM, Porzenheim MJ, Ramos-Guasp WA, Nieh EH, Felix-Ortiz AC, Namburi P, Leppla CA, Presbrey KN, Anandalingam KK, Pagan-Rivera PA, Anahtar M, Beyeler A, Tye KM. Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment. Nat Neurosci. 2017 Jun; 20(6):824-835. PMID: 28436980.
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    16. Matthews GA, Tye KM. A New Handle for a Hot Topic: Genetic Markers for Warm-Sensing. Cell. 2016 Sep 22; 167(1):43-44. PMID: 27662082.
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    17. Nieh EH, Vander Weele CM, Matthews GA, Presbrey KN, Wichmann R, Leppla CA, Izadmehr EM, Tye KM. Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation. Neuron. 2016 06 15; 90(6):1286-1298. PMID: 27238864.
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    18. Beyeler A, Namburi P, Glober GF, Simonnet C, Calhoon GG, Conyers GF, Luck R, Wildes CP, Tye KM. Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval. Neuron. 2016 04 20; 90(2):348-361. PMID: 27041499.
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    19. Matthews GA, Nieh EH, Vander Weele CM, Halbert SA, Pradhan RV, Yosafat AS, Glober GF, Izadmehr EM, Thomas RE, Lacy GD, Wildes CP, Ungless MA, Tye KM. Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation. Cell. 2016 Feb 11; 164(4):617-31. PMID: 26871628.
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    20. Namburi P, Al-Hasani R, Calhoon GG, Bruchas MR, Tye KM. Architectural Representation of Valence in the Limbic System. Neuropsychopharmacology. 2016 06; 41(7):1697-715. PMID: 26647973.
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    21. Calhoon GG, Tye KM. Resolving the neural circuits of anxiety. Nat Neurosci. 2015 Oct; 18(10):1394-404. PMID: 26404714.
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    22. Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat Neurosci. 2015 Sep; 18(9):1202-12. PMID: 26308981.
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    23. Felix-Ortiz AC, Burgos-Robles A, Bhagat ND, Leppla CA, Tye KM. Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex. Neuroscience. 2016 May 03; 321:197-209. PMID: 26204817.
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    24. Namburi P, Beyeler A, Yorozu S, Calhoon GG, Halbert SA, Wichmann R, Holden SS, Mertens KL, Anahtar M, Felix-Ortiz AC, Wickersham IR, Gray JM, Tye KM. A circuit mechanism for differentiating positive and negative associations. Nature. 2015 Apr 30; 520(7549):675-8. PMID: 25925480.
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    25. Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Mol Psychiatry. 2015 Nov; 20(11):1479-80. PMID: 25687774.
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    26. Nieh EH, Matthews GA, Allsop SA, Presbrey KN, Leppla CA, Wichmann R, Neve R, Wildes CP, Tye KM. Decoding neural circuits that control compulsive sucrose seeking. Cell. 2015 Jan 29; 160(3):528-41. PMID: 25635460.
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    27. Janak PH, Tye KM. From circuits to behaviour in the amygdala. Nature. 2015 Jan 15; 517(7534):284-92. PMID: 25592533.
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    28. Sidor MM, Davidson TJ, Tye KM, Warden MR, Diesseroth K, McClung CA. In vivo optogenetic stimulation of the rodent central nervous system. J Vis Exp. 2015 Jan 15; (95):51483. PMID: 25651158.
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    29. Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Mol Psychiatry. 2015 Nov; 20(11):1406-19. PMID: 25560763.
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    30. Tye KM. Neural circuit reprogramming: a new paradigm for treating neuropsychiatric disease? Neuron. 2014 Sep 17; 83(6):1259-61. PMID: 25233309.
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    31. Allsop SA, Vander Weele CM, Wichmann R, Tye KM. Optogenetic insights on the relationship between anxiety-related behaviors and social deficits. Front Behav Neurosci. 2014; 8:241. PMID: 25076878.
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    32. Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014 Aug; 17(8):1123-9. PMID: 24997763.
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    33. Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K. Natural neural projection dynamics underlying social behavior. Cell. 2014 Jun 19; 157(7):1535-51. PMID: 24949967.
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    34. Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM. PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol. 2014 Apr 01; 522(5):1171-90. PMID: 24264880.
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    35. Felix-Ortiz AC, Tye KM. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J Neurosci. 2014 Jan 08; 34(2):586-95. PMID: 24403157.
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    36. Beyeler A, Eckhardt CA, Tye KM. Deciphering memory function with optogenetics. Prog Mol Biol Transl Sci. 2014; 122:341-90. PMID: 24484707.
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    37. Felix-Ortiz AC, Beyeler A, Seo C, Leppla CA, Wildes CP, Tye KM. BLA to vHPC inputs modulate anxiety-related behaviors. Neuron. 2013 Aug 21; 79(4):658-64. PMID: 23972595.
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    38. Lammel S, Tye KM, Warden MR. Progress in understanding mood disorders: optogenetic dissection of neural circuits. Genes Brain Behav. 2014 Jan; 13(1):38-51. PMID: 23682971.
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    39. Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature. 2013 Apr 11; 496(7444):219-23. PMID: 23515158.
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    40. Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature. 2012 Dec 20; 492(7429):428-32. PMID: 23160494.
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    41. Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. 2013 Jan 24; 493(7433):537-541. PMID: 23235822.
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    42. Tye KM. Glutamate inputs to the nucleus accumbens: does source matter? Neuron. 2012 Nov 21; 76(4):671-3. PMID: 23177953.
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    43. Nieh EH, Kim SY, Namburi P, Tye KM. Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors. Brain Res. 2013 May 20; 1511:73-92. PMID: 23142759.
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    44. Lammel S, Lim BK, Ran C, Huang KW, Betley MJ, Tye KM, Deisseroth K, Malenka RC. Input-specific control of reward and aversion in the ventral tegmental area. Nature. 2012 Nov 08; 491(7423):212-7. PMID: 23064228.
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    45. Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouèbe G, Deisseroth K, Tye KM, Lüscher C. GABA neurons of the VTA drive conditioned place aversion. Neuron. 2012 Mar 22; 73(6):1173-83. PMID: 22445344.
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    46. Tye KM, Deisseroth K. Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci. 2012 Mar 20; 13(4):251-66. PMID: 22430017.
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    47. Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O'Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods. 2011 Dec 18; 9(2):159-72. PMID: 22179551.
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    48. Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 2011 Dec 08; 72(5):721-33. PMID: 22153370.
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    49. Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature. 2011 Jun 29; 475(7356):377-80. PMID: 21716290.
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    50. Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG. High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A. 2011 May 03; 108(18):7595-600. PMID: 21504945.
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    51. Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature. 2011 Mar 17; 471(7338):358-62. PMID: 21389985.
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    52. Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye K, Bonci A. Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. Neuron. 2010 Mar 11; 65(5):682-94. PMID: 20223203.
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    53. Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A. Methylphenidate facilitates learning-induced amygdala plasticity. Nat Neurosci. 2010 Apr; 13(4):475-81. PMID: 20208527.
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    54. Tye KM, Cone JJ, Schairer WW, Janak PH. Amygdala neural encoding of the absence of reward during extinction. J Neurosci. 2010 Jan 06; 30(1):116-25. PMID: 20053894.
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    55. Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Curr Top Behav Neurosci. 2010; 3:3-27. PMID: 21161748.
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    56. Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH. Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature. 2008 Jun 26; 453(7199):1253-7. PMID: 18469802.
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    57. Tye KM, Janak PH. Amygdala neurons differentially encode motivation and reinforcement. J Neurosci. 2007 Apr 11; 27(15):3937-45. PMID: 17428967.
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