Kay Tye

Title(s)Adjunct Professor, Neurobiology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Multispectral, high speed, super-resolution confocal microscopy system to support research in complex neurobiology
    NIH S10MH124757Aug 11, 2021 - Aug 10, 2022
    Role: Principal Investigator
    Exploring neural circuit mechanisms of social contact and social isolation
    NIH R01MH115920Jun 26, 2018 - Mar 31, 2023
    Role: Principal Investigator
    2018 Optogenetic Approaches to Understanding Neural Circuits & Behavior GRC
    NIH R13DA046191May 1, 2018 - Apr 30, 2019
    Role: Principal Investigator
    Neural Circuit Mechanisms of Social Homeostasis in Individuals and Supraorganismal Social Groups
    NIH DP1AT009925Sep 30, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Examination of neural circuits underlying mood disorders in Alzheimer?s disease
    NIH RF1AG047661Jul 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Solving the Valence Assignment Problem
    NIH R37MH102441Jan 15, 2014 - Feb 28, 2026
    Role: Principal Investigator
    Dissecting the Neural Circuits Encoding Positive and Negative Valence
    NIH R01MH102441Jan 15, 2014 - Nov 30, 2019
    Role: Principal Investigator
    A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
    NIH DP2DK102256Sep 30, 2013 - Aug 31, 2020
    Role: Principal Investigator
    The effects of thalamoamygdalar synaptic potentiation on learning performance
    NIH F32MH088010Sep 25, 2009 - Sep 24, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Social isolation recruits amygdala-cortical circuitry to escalate alcohol drinking. Res Sq. 2024 Mar 21. Patel RR, Patarino M, Kim K, Pamintuan R, Taschbach FH, Li H, Lee CR, van Hoek A, Castro R, Cazares C, Miranda RL, Jia C, Delahanty J, Batra K, Keyes LR, Libster A, Wichmann R, Pereira TD, Benna MK, Tye KM. PMID: 38562728; PMCID: PMC10984017.
      View in: PubMed   Mentions:
    2. Reward contingency gates selective cholinergic suppression of amygdala neurons. Elife. 2024 Feb 20; 12. Kimchi EY, Burgos-Robles A, Matthews GA, Chakoma T, Patarino M, Weddington JC, Siciliano C, Yang W, Foutch S, Simons R, Fong MF, Jing M, Li Y, Polley DB, Tye KM. PMID: 38376907; PMCID: PMC10942609.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    3. AlphaTracker: a multi-animal tracking and behavioral analysis tool. Front Behav Neurosci. 2023; 17:1111908. Chen Z, Zhang R, Fang HS, Zhang YE, Bal A, Zhou H, Rock RR, Padilla-Coreano N, Keyes LR, Zhu H, Li YL, Komiyama T, Tye KM, Lu C. PMID: 37324523; PMCID: PMC10266280.
      View in: PubMed   Mentions: 8  
    4. Anxiety and depression: A top-down, bottom-up model of circuit function. Ann N Y Acad Sci. 2023 07; 1525(1):70-87. LeDuke DO, Borio M, Miranda R, Tye KM. PMID: 37129246; PMCID: PMC10695657.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Thalamus sends information about arousal but not valence to the amygdala. Psychopharmacology (Berl). 2023 Mar; 240(3):477-499. Leppla CA, Keyes LR, Glober G, Matthews GA, Batra K, Jay M, Feng Y, Chen HS, Mills F, Delahanty J, Olson JM, Nieh EH, Namburi P, Wildes C, Wichmann R, Beyeler A, Kimchi EY, Tye KM. PMID: 36522481; PMCID: PMC9928937.
      View in: PubMed   Mentions: 1     Fields:    
    6. Neurotensin orchestrates valence assignment in the amygdala. Nature. 2022 08; 608(7923):586-592. Li H, Namburi P, Olson JM, Borio M, Lemieux ME, Beyeler A, Calhoon GG, Hitora-Imamura N, Coley AA, Libster A, Bal A, Jin X, Wang H, Jia C, Choudhury SR, Shi X, Felix-Ortiz AC, de la Fuente V, Barth VP, King HO, Izadmehr EM, Revanna JS, Batra K, Fischer KB, Keyes LR, Padilla-Coreano N, Siciliano CA, McCullough KM, Wichmann R, Ressler KJ, Fiete IR, Zhang F, Li Y, Tye KM. PMID: 35859170; PMCID: PMC9583860.
      View in: PubMed   Mentions: 16     Fields:    
    7. Dynamic influences on the neural encoding of social valence. Nat Rev Neurosci. 2022 09; 23(9):535-550. Padilla-Coreano N, Tye KM, Zelikowsky M. PMID: 35831442; PMCID: PMC9997616.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    8. Cortical ensembles orchestrate social competition through hypothalamic outputs. Nature. 2022 03; 603(7902):667-671. Padilla-Coreano N, Batra K, Patarino M, Chen Z, Rock RR, Zhang R, Hausmann SB, Weddington JC, Patel R, Zhang YE, Fang HS, Mishra S, LeDuke DO, Revanna J, Li H, Borio M, Pamintuan R, Bal A, Keyes LR, Libster A, Wichmann R, Mills F, Taschbach FH, Matthews GA, Curley JP, Fiete IR, Lu C, Tye KM. PMID: 35296862; PMCID: PMC9576144.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    9. Author Correction: Acute social isolation evokes midbrain craving responses similar to hunger. Nat Neurosci. 2022 Mar; 25(3):399. Tomova L, Wang KL, Thompson T, Matthews GA, Takahashi A, Tye KM, Saxe R. PMID: 34992257.
      View in: PubMed   Mentions: 2     Fields:    
    10. Neural systems that facilitate the representation of social rank. Philos Trans R Soc Lond B Biol Sci. 2022 02 28; 377(1845):20200444. Dwortz MF, Curley JP, Tye KM, Padilla-Coreano N. PMID: 35000438; PMCID: PMC8743891.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    11. The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation. Cell. 2021 May 13; 184(10):2794-2795. Lee CR, Chen A, Tye KM. PMID: 33989550.
      View in: PubMed   Mentions: 5     Fields:    
    12. The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation. Cell. 2021 03 18; 184(6):1500-1516. Lee CR, Chen A, Tye KM. PMID: 33691140; PMCID: PMC8580010.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    13. Valence processing in the PFC: Reconciling circuit-level and systems-level views. Int Rev Neurobiol. 2021; 158:171-212. Coley AA, Padilla-Coreano N, Patel R, Tye KM. PMID: 33785145.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    14. Acute social isolation evokes midbrain craving responses similar to hunger. Nat Neurosci. 2020 12; 23(12):1597-1605. Tomova L, Wang KL, Thompson T, Matthews GA, Takahashi A, Tye KM, Saxe R. PMID: 33230328; PMCID: PMC8580014.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    15. A modeling framework for adaptive lifelong learning with transfer and savings through gating in the prefrontal cortex. Proc Natl Acad Sci U S A. 2020 11 24; 117(47):29872-29882. Tsuda B, Tye KM, Siegelmann HT, Sejnowski TJ. PMID: 33154155; PMCID: PMC7703668.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    16. Context-dependent plasticity of adult-born neurons regulated by cortical feedback. Sci Adv. 2020 10; 6(42). Wu A, Yu B, Chen Q, Matthews GA, Lu C, Campbell E, Tye KM, Komiyama T. PMID: 33067236; PMCID: PMC7567600.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    17. Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator. Neuron. 2020 08 05; 107(3):470-486.e11. Shemesh OA, Linghu C, Piatkevich KD, Goodwin D, Celiker OT, Gritton HJ, Romano MF, Gao R, Yu CJ, Tseng HA, Bensussen S, Narayan S, Yang CT, Freifeld L, Siciliano CA, Gupta I, Wang J, Pak N, Yoon YG, Ullmann JFP, Guner-Ataman B, Noamany H, Sheinkopf ZR, Park WM, Asano S, Keating AE, Trimmer JS, Reimer J, Tolias AS, Bear MF, Tye KM, Han X, Ahrens MB, Boyden ES. PMID: 32592656; PMCID: PMC7415598.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    18. A cortical-brainstem circuit predicts and governs compulsive alcohol drinking. Science. 2019 11 22; 366(6468):1008-1012. Siciliano CA, Noamany H, Chang CJ, Brown AR, Chen X, Leible D, Lee JJ, Wang J, Vernon AN, Vander Weele CM, Kimchi EY, Heiman M, Tye KM. PMID: 31754002; PMCID: PMC6989100.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    19. The neuroscience of unmet social needs. Soc Neurosci. 2021 06; 16(3):221-231. Tomova L, Tye K, Saxe R. PMID: 31729923.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    20. Hippocampal-Prefrontal Theta Transmission Regulates Avoidance Behavior. Neuron. 2019 11 06; 104(3):601-610.e4. Padilla-Coreano N, Canetta S, Mikofsky RM, Alway E, Passecker J, Myroshnychenko MV, Garcia-Garcia AL, Warren R, Teboul E, Blackman DR, Morton MP, Hupalo S, Tye KM, Kellendonk C, Kupferschmidt DA, Gordon JA. PMID: 31521441; PMCID: PMC6842114.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    21. Viewpoints: Approaches to defining and investigating fear. Nat Neurosci. 2019 08; 22(8):1205-1216. Mobbs D, Adolphs R, Fanselow MS, Barrett LF, LeDoux JE, Ressler K, Tye KM. PMID: 31332374; PMCID: PMC6943931.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    22. Neural mechanisms of social homeostasis. Ann N Y Acad Sci. 2019 12; 1457(1):5-25. Matthews GA, Tye KM. PMID: 30875095; PMCID: PMC7593988.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    23. Dopamine tunes prefrontal outputs to orchestrate aversive processing. Brain Res. 2019 06 15; 1713:16-31. Weele CMV, Siciliano CA, Tye KM. PMID: 30513287; PMCID: PMC7575248.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    24. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. Nature. 2018 11; 563(7731):397-401. Vander Weele CM, Siciliano CA, Matthews GA, Namburi P, Izadmehr EM, Espinel IC, Nieh EH, Schut EHS, Padilla-Coreano N, Burgos-Robles A, Chang CJ, Kimchi EY, Beyeler A, Wichmann R, Wildes CP, Tye KM. PMID: 30405240; PMCID: PMC6645392.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    25. Neural Circuit Motifs in Valence Processing. Neuron. 2018 10 24; 100(2):436-452. Tye KM. PMID: 30359607; PMCID: PMC6590698.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimals
    26. Double threat in striatal dopamine signaling. Nat Neurosci. 2018 10; 21(10):1296-1297. Siciliano CA, Mills F, Tye KM. PMID: 30258236; PMCID: PMC7683097.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    27. Leveraging calcium imaging to illuminate circuit dysfunction in addiction. Alcohol. 2019 02; 74:47-63. Siciliano CA, Tye KM. PMID: 30470589; PMCID: PMC7575247.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    28. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell. 2018 05 31; 173(6):1329-1342.e18. Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM. PMID: 29731170; PMCID: PMC6345560.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    29. Editorial overview: Neurobiology of behavior. Curr Opin Neurobiol. 2018 04; 49:iv-ix. Tye KM, Uchida N. PMID: 29526385.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    30. Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons. Nat Neurosci. 2018 04; 21(4):638-646. Chatterjee S, Sullivan HA, MacLennan BJ, Xu R, Hou Y, Lavin TK, Lea NE, Michalski JE, Babcock KR, Dietrich S, Matthews GA, Beyeler A, Calhoon GG, Glober G, Whitesell JD, Yao S, Cetin A, Harris JA, Zeng H, Tye KM, Reid RC, Wickersham IR. PMID: 29507411; PMCID: PMC6503322.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    31. Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala. Cell Rep. 2018 01 23; 22(4):905-918. Beyeler A, Chang CJ, Silvestre M, Lévêque C, Namburi P, Wildes CP, Tye KM. PMID: 29386133; PMCID: PMC5891824.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    32. A light- and calcium-gated transcription factor for imaging and manipulating activated neurons. Nat Biotechnol. 2017 Sep; 35(9):864-871. Wang W, Wildes CP, Pattarabanjird T, Sanchez MI, Glober GF, Matthews GA, Tye KM, Ting AY. PMID: 28650461; PMCID: PMC5595644.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    33. Endocannabinoid Signaling in the Control of Social Behavior. Trends Neurosci. 2017 07; 40(7):385-396. Wei D, Allsop S, Tye K, Piomelli D. PMID: 28554687; PMCID: PMC5699224.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    34. Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment. Nat Neurosci. 2017 Jun; 20(6):824-835. Burgos-Robles A, Kimchi EY, Izadmehr EM, Porzenheim MJ, Ramos-Guasp WA, Nieh EH, Felix-Ortiz AC, Namburi P, Leppla CA, Presbrey KN, Anandalingam KK, Pagan-Rivera PA, Anahtar M, Beyeler A, Tye KM. PMID: 28436980; PMCID: PMC5448704.
      View in: PubMed   Mentions: 138     Fields:    Translation:Animals
    35. A New Handle for a Hot Topic: Genetic Markers for Warm-Sensing. Cell. 2016 Sep 22; 167(1):43-44. Matthews GA, Tye KM. PMID: 27662082.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation. Neuron. 2016 06 15; 90(6):1286-1298. Nieh EH, Vander Weele CM, Matthews GA, Presbrey KN, Wichmann R, Leppla CA, Izadmehr EM, Tye KM. PMID: 27238864; PMCID: PMC4961212.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    37. Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval. Neuron. 2016 04 20; 90(2):348-361. Beyeler A, Namburi P, Glober GF, Simonnet C, Calhoon GG, Conyers GF, Luck R, Wildes CP, Tye KM. PMID: 27041499; PMCID: PMC4854303.
      View in: PubMed   Mentions: 178     Fields:    Translation:Animals
    38. Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation. Cell. 2016 Feb 11; 164(4):617-31. Matthews GA, Nieh EH, Vander Weele CM, Halbert SA, Pradhan RV, Yosafat AS, Glober GF, Izadmehr EM, Thomas RE, Lacy GD, Wildes CP, Ungless MA, Tye KM. PMID: 26871628; PMCID: PMC4752823.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    39. Architectural Representation of Valence in the Limbic System. Neuropsychopharmacology. 2016 06; 41(7):1697-715. Namburi P, Al-Hasani R, Calhoon GG, Bruchas MR, Tye KM. PMID: 26647973; PMCID: PMC4869057.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    40. Resolving the neural circuits of anxiety. Nat Neurosci. 2015 Oct; 18(10):1394-404. Calhoon GG, Tye KM. PMID: 26404714; PMCID: PMC7575249.
      View in: PubMed   Mentions: 270     Fields:    Translation:HumansAnimals
    41. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nat Neurosci. 2015 Sep; 18(9):1202-12. Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI. PMID: 26308981.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    42. Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex. Neuroscience. 2016 May 03; 321:197-209. Felix-Ortiz AC, Burgos-Robles A, Bhagat ND, Leppla CA, Tye KM. PMID: 26204817; PMCID: PMC4721937.
      View in: PubMed   Mentions: 174     Fields:    Translation:Animals
    43. A circuit mechanism for differentiating positive and negative associations. Nature. 2015 Apr 30; 520(7549):675-8. Namburi P, Beyeler A, Yorozu S, Calhoon GG, Halbert SA, Wichmann R, Holden SS, Mertens KL, Anahtar M, Felix-Ortiz AC, Wickersham IR, Gray JM, Tye KM. PMID: 25925480; PMCID: PMC4418228.
      View in: PubMed   Mentions: 268     Fields:    Translation:AnimalsCells
    44. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Mol Psychiatry. 2015 Nov; 20(11):1479-80. Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA. PMID: 25687774; PMCID: PMC5152674.
      View in: PubMed   Mentions: 12     Fields:    
    45. Decoding neural circuits that control compulsive sucrose seeking. Cell. 2015 Jan 29; 160(3):528-41. Nieh EH, Matthews GA, Allsop SA, Presbrey KN, Leppla CA, Wichmann R, Neve R, Wildes CP, Tye KM. PMID: 25635460; PMCID: PMC4312417.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    46. In vivo optogenetic stimulation of the rodent central nervous system. J Vis Exp. 2015 Jan 15; (95):51483. Sidor MM, Davidson TJ, Tye KM, Warden MR, Diesseroth K, McClung CA. PMID: 25651158; PMCID: PMC4354526.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    47. From circuits to behaviour in the amygdala. Nature. 2015 Jan 15; 517(7534):284-92. Janak PH, Tye KM. PMID: 25592533; PMCID: PMC4565157.
      View in: PubMed   Mentions: 757     Fields:    Translation:HumansAnimals
    48. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Mol Psychiatry. 2015 Nov; 20(11):1406-19. Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA. PMID: 25560763; PMCID: PMC4492925.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    49. Neural circuit reprogramming: a new paradigm for treating neuropsychiatric disease? Neuron. 2014 Sep 17; 83(6):1259-61. Tye KM. PMID: 25233309; PMCID: PMC4565154.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    50. Optogenetic insights on the relationship between anxiety-related behaviors and social deficits. Front Behav Neurosci. 2014; 8:241. Allsop SA, Vander Weele CM, Wichmann R, Tye KM. PMID: 25076878; PMCID: PMC4099964.
      View in: PubMed   Mentions: 77  
    51. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014 Aug; 17(8):1123-9. Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES. PMID: 24997763; PMCID: PMC4184214.
      View in: PubMed   Mentions: 233     Fields:    Translation:AnimalsCells
    52. Natural neural projection dynamics underlying social behavior. Cell. 2014 Jun 19; 157(7):1535-51. Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K. PMID: 24949967; PMCID: PMC4123133.
      View in: PubMed   Mentions: 621     Fields:    Translation:AnimalsCells
    53. PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol. 2014 Apr 01; 522(5):1171-90. Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM. PMID: 24264880; PMCID: PMC3945606.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    54. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J Neurosci. 2014 Jan 08; 34(2):586-95. Felix-Ortiz AC, Tye KM. PMID: 24403157; PMCID: PMC3870937.
      View in: PubMed   Mentions: 224     Fields:    Translation:Animals
    55. Deciphering memory function with optogenetics. Prog Mol Biol Transl Sci. 2014; 122:341-90. Beyeler A, Eckhardt CA, Tye KM. PMID: 24484707.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    56. BLA to vHPC inputs modulate anxiety-related behaviors. Neuron. 2013 Aug 21; 79(4):658-64. Felix-Ortiz AC, Beyeler A, Seo C, Leppla CA, Wildes CP, Tye KM. PMID: 23972595; PMCID: PMC4205569.
      View in: PubMed   Mentions: 261     Fields:    Translation:AnimalsCells
    57. Progress in understanding mood disorders: optogenetic dissection of neural circuits. Genes Brain Behav. 2014 Jan; 13(1):38-51. Lammel S, Tye KM, Warden MR. PMID: 23682971.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    58. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature. 2013 Apr 11; 496(7444):219-23. Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K. PMID: 23515158; PMCID: PMC6690364.
      View in: PubMed   Mentions: 328     Fields:    Translation:Animals
    59. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature. 2012 Dec 20; 492(7429):428-32. Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K. PMID: 23160494; PMCID: PMC5929119.
      View in: PubMed   Mentions: 288     Fields:    Translation:AnimalsCells
    60. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. 2013 Jan 24; 493(7433):537-541. Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. PMID: 23235822; PMCID: PMC4160519.
      View in: PubMed   Mentions: 465     Fields:    Translation:AnimalsCells
    61. Glutamate inputs to the nucleus accumbens: does source matter? Neuron. 2012 Nov 21; 76(4):671-3. Tye KM. PMID: 23177953.
      View in: PubMed   Mentions: 10     Fields:    
    62. Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors. Brain Res. 2013 May 20; 1511:73-92. Nieh EH, Kim SY, Namburi P, Tye KM. PMID: 23142759; PMCID: PMC4099056.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    63. Input-specific control of reward and aversion in the ventral tegmental area. Nature. 2012 Nov 08; 491(7423):212-7. Lammel S, Lim BK, Ran C, Huang KW, Betley MJ, Tye KM, Deisseroth K, Malenka RC. PMID: 23064228; PMCID: PMC3493743.
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    64. GABA neurons of the VTA drive conditioned place aversion. Neuron. 2012 Mar 22; 73(6):1173-83. Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouèbe G, Deisseroth K, Tye KM, Lüscher C. PMID: 22445344; PMCID: PMC6690362.
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    65. Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci. 2012 Mar 20; 13(4):251-66. Tye KM, Deisseroth K. PMID: 22430017; PMCID: PMC6682316.
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    66. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Methods. 2011 Dec 18; 9(2):159-72. Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O'Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K. PMID: 22179551; PMCID: PMC4165888.
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    67. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 2011 Dec 08; 72(5):721-33. Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K. PMID: 22153370; PMCID: PMC3282061.
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    68. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature. 2011 Jun 29; 475(7356):377-80. Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A. PMID: 21716290; PMCID: PMC3775282.
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    69. High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci U S A. 2011 May 03; 108(18):7595-600. Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG. PMID: 21504945; PMCID: PMC3088623.
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    70. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature. 2011 Mar 17; 471(7338):358-62. Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K. PMID: 21389985; PMCID: PMC3154022.
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    71. Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. Neuron. 2010 Mar 11; 65(5):682-94. Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye K, Bonci A. PMID: 20223203; PMCID: PMC2847608.
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    72. Methylphenidate facilitates learning-induced amygdala plasticity. Nat Neurosci. 2010 Apr; 13(4):475-81. Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A. PMID: 20208527; PMCID: PMC2988577.
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    73. Amygdala neural encoding of the absence of reward during extinction. J Neurosci. 2010 Jan 06; 30(1):116-25. Tye KM, Cone JJ, Schairer WW, Janak PH. PMID: 20053894; PMCID: PMC6632518.
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    74. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Curr Top Behav Neurosci. 2010; 3:3-27. Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A. PMID: 21161748.
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    75. Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature. 2008 Jun 26; 453(7199):1253-7. Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH. PMID: 18469802; PMCID: PMC2759353.
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    76. Amygdala neurons differentially encode motivation and reinforcement. J Neurosci. 2007 Apr 11; 27(15):3937-45. Tye KM, Janak PH. PMID: 17428967; PMCID: PMC6672525.
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