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Binhai Zheng

Title(s)Professor, Neurosciences
SchoolHealth Sciences
Phone858-534-5807
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    Collapse Research 
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    Harnessing Corticospinal Axon Sprouting for Functional Recovery in Chronic Injury
    VA I01RX002483Nov 1, 2018 - Oct 31, 2023
    Role: Principal Investigator
    Roles of a novel MAPKKK in axonal responses to injury in the mammalian CNS
    NIH/NINDS R01NS093055May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Exploring the role of microRNAs in injury-induced axonal growth in the CNS
    NIH/NINDS R21NS088536Jul 1, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Genetic analysis of myelin inhibitors and PTEN in injury-inducedCNS axon growth
    NIH/NINDS R01NS054734Apr 1, 2006 - May 31, 2016
    Role: Principal Investigator
    University of California San Diego Neuroscience Microscopy Imaging Core
    NIH/NINDS P30NS047101Sep 30, 2003 - Nov 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jin Y, Zheng B. Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management. Annu Rev Cell Dev Biol. 2019 Oct 06; 35:501-521. PMID: 31590586.
      View in: PubMed
    2. Zheng B, Nimmerjahn A. Editorial for "In vivo spinal cord imaging in health, injury and disease". Exp Neurol. 2019 Aug 20; 322:113038. PMID: 31698157.
      View in: PubMed
    3. Zheng B, Lorenzana AO, Ma L. Understanding the axonal response to injury by in vivo imaging in the mouse spinal cord: A tale of two branches. Exp Neurol. 2019 Aug; 318:277-285. PMID: 30986398.
      View in: PubMed
    4. Meves JM, Geoffroy CG, Kim ND, Kim JJ, Zheng B. Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury. Exp Neurol. 2018 11; 309:32-43. PMID: 30055160.
      View in: PubMed
    5. Poplawski GHD, Lie R, Hunt M, Kumamaru H, Kawaguchi R, Lu P, Schäfer MKE, Woodruff G, Robinson J, Canete P, Dulin JN, Geoffroy CG, Menzel L, Zheng B, Coppola G, Tuszynski MH. Adult rat myelin enhances axonal outgrowth from neural stem cells. Sci Transl Med. 2018 05 23; 10(442). PMID: 29794059.
      View in: PubMed
    6. Narang A, Zheng B. To Scar or Not to Scar. Trends Mol Med. 2018 06; 24(6):522-524. PMID: 29729835.
      View in: PubMed
    7. Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke CL, Carolino KI, Elzière L, Goldberg MP, Jin Y, Zheng B. Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep. 2018 03 27; 22(13):3587-3597. PMID: 29590625.
      View in: PubMed
    8. Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B. In Vivo Imaging of CNS Injury and Disease. J Neurosci. 2017 11 08; 37(45):10808-10816. PMID: 29118209.
      View in: PubMed
    9. Geoffroy CG, Meves JM, Zheng B. The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms. Neurosci Lett. 2017 Jun 23; 652:41-49. PMID: 27818358.
      View in: PubMed
    10. Meves JM, Zheng B. Synaptic Suppression of Axon Regeneration. Neuron. 2016 Oct 19; 92(2):267-269. PMID: 27764657.
      View in: PubMed
    11. Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B. Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Sci Rep. 2016 08 11; 6:31482. PMID: 27511108.
      View in: PubMed
    12. Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B. Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System. Cell Rep. 2016 Apr 12; 15(2):238-46. PMID: 27050519.
      View in: PubMed
    13. Lorenzana AO, Lee JK, Mui M, Chang A, Zheng B. A surviving intact branch stabilizes remaining axon architecture after injury as revealed by in vivo imaging in the mouse spinal cord. Neuron. 2015 May 20; 86(4):947-954. PMID: 25937174.
      View in: PubMed
    14. Chen M, Zheng B. Axon plasticity in the mammalian central nervous system after injury. Trends Neurosci. 2014 Oct; 37(10):583-93. PMID: 25218468.
      View in: PubMed
    15. Tuszynski MH, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cells in models of spinal cord injury. Exp Neurol. 2014 Nov; 261:494-500. PMID: 25079369.
      View in: PubMed
    16. Geoffroy CG, Zheng B. Myelin-associated inhibitors in axonal growth after CNS injury. Curr Opin Neurobiol. 2014 Aug; 27:31-8. PMID: 24608164.
      View in: PubMed
    17. Meves JM, Zheng B. Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury. Neural Regen Res. 2014 Mar 01; 9(5):460-1. PMID: 25206838.
      View in: PubMed
    18. Tuszynski MH, Wang Y, Graham L, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cell dissemination after grafting to CNS injury sites. Cell. 2014 Jan 30; 156(3):388-9. PMID: 24485445.
      View in: PubMed
    19. Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14; 150(6):1264-73. PMID: 22980985.
      View in: PubMed
    20. Lee JK, Zheng B. Role of myelin-associated inhibitors in axonal repair after spinal cord injury. Exp Neurol. 2012 May; 235(1):33-42. PMID: 21596039.
      View in: PubMed
    21. Lee JK, Chow R, Xie F, Chow SY, Tolentino KE, Zheng B. Combined genetic attenuation of myelin and semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration. J Neurosci. 2010 Aug 11; 30(32):10899-904. PMID: 20702718.
      View in: PubMed
    22. Lee JK, Geoffroy CG, Chan AF, Tolentino KE, Crawford MJ, Leal MA, Kang B, Zheng B. Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron. 2010 Jun 10; 66(5):663-70. PMID: 20547125.
      View in: PubMed
    23. Hollis ER, Jamshidi P, Lorenzana AO, Lee JK, Gray SJ, Samulski RJ, Zheng B, Tuszynski MH. Transient demyelination increases the efficiency of retrograde AAV transduction. Mol Ther. 2010 Aug; 18(8):1496-500. PMID: 20502445.
      View in: PubMed
    24. Masliah E, Xie F, Dayan S, Rockenstein E, Mante M, Adame A, Patrick CM, Chan AF, Zheng B. Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice. Neuroscience. 2010 Aug 11; 169(1):488-94. PMID: 20433905.
      View in: PubMed
    25. Herrmann JE, Shah RR, Chan AF, Zheng B. EphA4 deficient mice maintain astroglial-fibrotic scar formation after spinal cord injury. Exp Neurol. 2010 Jun; 223(2):582-98. PMID: 20170651.
      View in: PubMed
    26. Herrmann JE, Pence MA, Shapera EA, Shah RR, Geoffroy CG, Zheng B. Generation of an EphA4 conditional allele in mice. Genesis. 2010 Feb; 48(2):101-5. PMID: 20014422.
      View in: PubMed
    27. Lee JK, Case LC, Chan AF, Zhu Y, Tessier-Lavigne M, Zheng B. Generation of an OMgp allelic series in mice. Genesis. 2009 Nov; 47(11):751-6. PMID: 19672953.
      View in: PubMed
    28. Lee JK, Chan AF, Luu SM, Zhu Y, Ho C, Tessier-Lavigne M, Zheng B. Reassessment of corticospinal tract regeneration in Nogo-deficient mice. J Neurosci. 2009 Jul 08; 29(27):8649-54. PMID: 19587271.
      View in: PubMed
    29. Ruby KM, Zheng B. Gene targeting in a HUES line of human embryonic stem cells via electroporation. Stem Cells. 2009 Jul; 27(7):1496-506. PMID: 19544466.
      View in: PubMed
    30. Tang T, Zheng B, Chen SH, Murphy AN, Kudlicka K, Zhou H, Farquhar MG. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. J Biol Chem. 2009 Feb 20; 284(8):5414-24. PMID: 19103604.
      View in: PubMed
    31. Lee JK, Zheng B. Axon regeneration after spinal cord injury: insight from genetically modified mouse models. Restor Neurol Neurosci. 2008; 26(2-3):175-82. PMID: 18820409.
      View in: PubMed
    32. Davalos D, Lee JK, Smith WB, Brinkman B, Ellisman MH, Zheng B, Akassoglou K. Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods. 2008 Mar 30; 169(1):1-7. PMID: 18192022.
      View in: PubMed
    33. Xie F, Zheng B. White matter inhibitors in CNS axon regeneration failure. Exp Neurol. 2008 Feb; 209(2):302-12. PMID: 17706966.
      View in: PubMed
    34. Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, Zheng B, Akassoglou K. Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11814-9. PMID: 17606926.
      View in: PubMed
    35. Zheng B, Tang T, Tang N, Kudlicka K, Ohtsubo K, Ma P, Marth JD, Farquhar MG, Lehtonen E. Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16776-81. PMID: 17077144.
      View in: PubMed
    36. Zheng B, Lee JK, Xie F. Genetic mouse models for studying inhibitors of spinal axon regeneration. Trends Neurosci. 2006 Nov; 29(11):640-6. PMID: 17030430.
      View in: PubMed
    37. Zheng B, Lavoie C, Tang TD, Ma P, Meerloo T, Beas A, Farquhar MG. Regulation of epidermal growth factor receptor degradation by heterotrimeric Galphas protein. Mol Biol Cell. 2004 Dec; 15(12):5538-50. PMID: 15469987.
      View in: PubMed
    38. Zheng B, Berrie CP, Corda D, Farquhar MG. GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1745-50. PMID: 12576545.
      View in: PubMed
    39. Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science. 2001 Nov 30; 294(5548):1939-42. PMID: 11729322.
      View in: PubMed
    40. Zheng B, Chen D, Farquhar MG. MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):3999-4004. PMID: 10760272.
      View in: PubMed
    41. De Vries L, Zheng B, Fischer T, Elenko E, Farquhar MG. The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol. 2000; 40:235-71. PMID: 10836135.
      View in: PubMed
    42. Zheng B, De Vries L, Gist Farquhar M. Divergence of RGS proteins: evidence for the existence of six mammalian RGS subfamilies. Trends Biochem Sci. 1999 Nov; 24(11):411-4. PMID: 10542401.
      View in: PubMed
    43. De Vries L, Lou X, Zhao G, Zheng B, Farquhar MG. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12340-5. PMID: 9770488.
      View in: PubMed