Binhai Zheng

Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-3906-3722 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Fudan University, Shanghai, ChinaUG02/1992Genetics
    University of Kentucky, Lexington, KentuckyMS05/1995Biology
    Baylor College of Medicine, Houston, TexasPhD09/1999Genetics
    UCSF/Stanford/Genentech, Bay Area, CaliforniaPostdoc12/2004Neuroscience
    University of California San Diego, La Jolla, California11/2021Senior Faculty Mentor Training
    Collapse Awards and Honors
    UCSF/Stanford2001  - 2004Helen Hay Whitney Foundation Postdoctoral Fellowship

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Harnessing Corticospinal Axon Sprouting for Functional Recovery in Chronic Injury
    NIH I01RX002483Nov 1, 2018 - Oct 31, 2023
    Role: Principal Investigator
    The role of a pair of MAP3Ks in the multicellular response to spinal cord injury
    NIH R01NS093055May 1, 2015 - Apr 30, 2025
    Role: Principal Investigator
    Exploring the role of microRNAs in injury-induced axonal growth in the CNS
    NIH R21NS088536Jul 1, 2014 - Mar 31, 2017
    Role: Principal Investigator
    Genetic analysis of myelin inhibitors and PTEN in injury-inducedCNS axon growth
    NIH R01NS054734Apr 1, 2006 - May 31, 2017
    Role: Principal Investigator
    University of California San Diego Neuroscience Microscopy Imaging Core
    NIH P30NS047101Sep 30, 2003 - Nov 30, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration. Neuron. 2023 Dec 20; 111(24):3953-3969.e5. Kim HJ, Saikia JM, Monte KMA, Ha E, Romaus-Sanjurjo D, Sanchez JJ, Moore AX, Hernaiz-Llorens M, Chavez-Martinez CL, Agba CK, Li H, Zhang J, Lusk DT, Cervantes KM, Zheng B. PMID: 37848024; PMCID: PMC10843387.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    2. Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq. Res Sq. 2023 Feb 21. Kim H, Saikia J, Monte K, Ha E, Romaus-Sanjurjo D, Sanchez J, Moore A, Hernaiz-Llorens M, Chavez-Martinez C, Agba C, Li H, Lusk D, Cervantes K, Zheng B. PMID: 36865182; PMCID: PMC9980198.
      View in: PubMed   Mentions:
    3. Regulation of axonal regeneration after mammalian spinal cord injury. Nat Rev Mol Cell Biol. 2023 06; 24(6):396-413. Zheng B, Tuszynski MH. PMID: 36604586.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    4. Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting. iScience. 2022 Nov 18; 25(11):105383. Geoffroy CG, Meves JM, Kim HJM, Romaus-Sanjurjo D, Sutherland TC, Li JJ, Suen J, Sanchez JJ, Zheng B. PMID: 36339257; PMCID: PMC9626739.
      View in: PubMed   Mentions: 2  
    5. Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury. Cell Death Discov. 2022 Sep 20; 8(1):390. Romaus-Sanjurjo D, Saikia JM, Kim HJ, Tsai KM, Le GQ, Zheng B. PMID: 36123349; PMCID: PMC9485247.
      View in: PubMed   Mentions: 6  
    6. Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. Elife. 2021 01 21; 10. Li Y, Ritchie EM, Steinke CL, Qi C, Chen L, Zheng B, Jin Y. PMID: 33475086; PMCID: PMC7870138.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Injured adult neurons regress to an embryonic transcriptional growth state. Nature. 2020 05; 581(7806):77-82. Poplawski GHD, Kawaguchi R, Van Niekerk E, Lu P, Mehta N, Canete P, Lie R, Dragatsis I, Meves JM, Zheng B, Coppola G, Tuszynski MH. PMID: 32376949.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    8. Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management. Annu Rev Cell Dev Biol. 2019 10 06; 35:501-521. Jin Y, Zheng B. PMID: 31590586; PMCID: PMC7015696.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    9. Editorial for "In vivo spinal cord imaging in health, injury and disease". Exp Neurol. 2019 12; 322:113038. Zheng B, Nimmerjahn A. PMID: 31698157.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Understanding the axonal response to injury by in vivo imaging in the mouse spinal cord: A tale of two branches. Exp Neurol. 2019 08; 318:277-285. Zheng B, Lorenzana AO, Ma L. PMID: 30986398; PMCID: PMC6588497.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury. Exp Neurol. 2018 11; 309:32-43. Meves JM, Geoffroy CG, Kim ND, Kim JJ, Zheng B. PMID: 30055160; PMCID: PMC6139267.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. Adult rat myelin enhances axonal outgrowth from neural stem cells. Sci Transl Med. 2018 05 23; 10(442). Poplawski GHD, Lie R, Hunt M, Kumamaru H, Kawaguchi R, Lu P, Schäfer MKE, Woodruff G, Robinson J, Canete P, Dulin JN, Geoffroy CG, Menzel L, Zheng B, Coppola G, Tuszynski MH. PMID: 29794059; PMCID: PMC8377986.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    13. To Scar or Not to Scar. Trends Mol Med. 2018 06; 24(6):522-524. Narang A, Zheng B. PMID: 29729835; PMCID: PMC5975241.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep. 2018 03 27; 22(13):3587-3597. Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke CL, Carolino KI, Elzière L, Goldberg MP, Jin Y, Zheng B. PMID: 29590625; PMCID: PMC5905706.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    15. In Vivo Imaging of CNS Injury and Disease. J Neurosci. 2017 11 08; 37(45):10808-10816. Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B. PMID: 29118209; PMCID: PMC5678013.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    16. The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms. Neurosci Lett. 2017 Jun 23; 652:41-49. Geoffroy CG, Meves JM, Zheng B. PMID: 27818358; PMCID: PMC5415436.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    17. Synaptic Suppression of Axon Regeneration. Neuron. 2016 Oct 19; 92(2):267-269. Meves JM, Zheng B. PMID: 27764657.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Sci Rep. 2016 08 11; 6:31482. Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B. PMID: 27511108; PMCID: PMC4980599.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    19. Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System. Cell Rep. 2016 Apr 12; 15(2):238-46. Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B. PMID: 27050519; PMCID: PMC5050004.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    20. A surviving intact branch stabilizes remaining axon architecture after injury as revealed by in vivo imaging in the mouse spinal cord. Neuron. 2015 May 20; 86(4):947-954. Lorenzana AO, Lee JK, Mui M, Chang A, Zheng B. PMID: 25937174; PMCID: PMC4441580.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    21. Axon plasticity in the mammalian central nervous system after injury. Trends Neurosci. 2014 Oct; 37(10):583-93. Chen M, Zheng B. PMID: 25218468; PMCID: PMC4190162.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    22. Neural stem cells in models of spinal cord injury. Exp Neurol. 2014 Nov; 261:494-500. Tuszynski MH, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. PMID: 25079369.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Myelin-associated inhibitors in axonal growth after CNS injury. Curr Opin Neurobiol. 2014 Aug; 27:31-8. Geoffroy CG, Zheng B. PMID: 24608164; PMCID: PMC4122599.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    24. Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury. Neural Regen Res. 2014 Mar 01; 9(5):460-1. Meves JM, Zheng B. PMID: 25206838; PMCID: PMC4153497.
      View in: PubMed   Mentions: 5  
    25. Neural stem cell dissemination after grafting to CNS injury sites. Cell. 2014 Jan 30; 156(3):388-9. Tuszynski MH, Wang Y, Graham L, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. PMID: 24485445.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    26. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14; 150(6):1264-73. Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. PMID: 22980985; PMCID: PMC3445432.
      View in: PubMed   Mentions: 390     Fields:    Translation:HumansAnimalsCells
    27. Role of myelin-associated inhibitors in axonal repair after spinal cord injury. Exp Neurol. 2012 May; 235(1):33-42. Lee JK, Zheng B. PMID: 21596039; PMCID: PMC3170678.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    28. Combined genetic attenuation of myelin and semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration. J Neurosci. 2010 Aug 11; 30(32):10899-904. Lee JK, Chow R, Xie F, Chow SY, Tolentino KE, Zheng B. PMID: 20702718; PMCID: PMC2974627.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    29. Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron. 2010 Jun 10; 66(5):663-70. Lee JK, Geoffroy CG, Chan AF, Tolentino KE, Crawford MJ, Leal MA, Kang B, Zheng B. PMID: 20547125; PMCID: PMC2896331.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    30. Transient demyelination increases the efficiency of retrograde AAV transduction. Mol Ther. 2010 Aug; 18(8):1496-500. Hollis ER, Jamshidi P, Lorenzana AO, Lee JK, Gray SJ, Samulski RJ, Zheng B, Tuszynski MH. PMID: 20502445; PMCID: PMC2927074.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice. Neuroscience. 2010 Aug 11; 169(1):488-94. Masliah E, Xie F, Dayan S, Rockenstein E, Mante M, Adame A, Patrick CM, Chan AF, Zheng B. PMID: 20433905; PMCID: PMC2900402.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    32. EphA4 deficient mice maintain astroglial-fibrotic scar formation after spinal cord injury. Exp Neurol. 2010 Jun; 223(2):582-98. Herrmann JE, Shah RR, Chan AF, Zheng B. PMID: 20170651; PMCID: PMC2864333.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    33. Generation of an EphA4 conditional allele in mice. Genesis. 2010 Feb; 48(2):101-5. Herrmann JE, Pence MA, Shapera EA, Shah RR, Geoffroy CG, Zheng B. PMID: 20014422; PMCID: PMC2819605.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    34. Generation of an OMgp allelic series in mice. Genesis. 2009 Nov; 47(11):751-6. Lee JK, Case LC, Chan AF, Zhu Y, Tessier-Lavigne M, Zheng B. PMID: 19672953; PMCID: PMC2788017.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    35. Reassessment of corticospinal tract regeneration in Nogo-deficient mice. J Neurosci. 2009 Jul 08; 29(27):8649-54. Lee JK, Chan AF, Luu SM, Zhu Y, Ho C, Tessier-Lavigne M, Zheng B. PMID: 19587271; PMCID: PMC2747754.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    36. Gene targeting in a HUES line of human embryonic stem cells via electroporation. Stem Cells. 2009 Jul; 27(7):1496-506. Ruby KM, Zheng B. PMID: 19544466.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    37. Axon regeneration after spinal cord injury: insight from genetically modified mouse models. Restor Neurol Neurosci. 2008; 26(2-3):175-82. Lee JK, Zheng B. PMID: 18820409; PMCID: PMC2646464.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    38. Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods. 2008 Mar 30; 169(1):1-7. Davalos D, Lee JK, Smith WB, Brinkman B, Ellisman MH, Zheng B, Akassoglou K. PMID: 18192022; PMCID: PMC2647134.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    39. White matter inhibitors in CNS axon regeneration failure. Exp Neurol. 2008 Feb; 209(2):302-12. Xie F, Zheng B. PMID: 17706966; PMCID: PMC2259386.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    40. Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11814-9. Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, Zheng B, Akassoglou K. PMID: 17606926; PMCID: PMC1913857.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    41. Genetic mouse models for studying inhibitors of spinal axon regeneration. Trends Neurosci. 2006 Nov; 29(11):640-6. Zheng B, Lee JK, Xie F. PMID: 17030430.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
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