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Derek Welsbie

Title(s)Associate Professor, Ophthalmology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Kinase Multitargeting for Glaucoma Neuroprotection
    NIH R01EY029342Sep 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    An RNAi Screen for Genes that Modulate Retinal Ganglion Cell Survival
    NIH R21EY022769Sep 1, 2012 - Aug 31, 2014
    Role: Co-Principal Investigator
    High-content high-throughput functional genomics in retinal ganglion cells
    NIH K08EY022078Dec 1, 2011 - Nov 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Progressive Thinning of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in Glaucoma Eyes with Disc Hemorrhage. Ophthalmol Glaucoma. 2021 Jan 30. Liu X, Lau A, Hou H, Moghimi S, Proudfoot JA, Chan E, Do J, Camp A, Welsbie D, de Moraes CG, Girkin CA, Liebmann JM, Weinreb RN. PMID: 33529795.
      View in: PubMed   Mentions:
    2. Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Proc Natl Acad Sci U S A. 2020 Dec 14. Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS. PMID: 33318207.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Sheath-Preserving Optic Nerve Transection in Rats to Assess Axon Regeneration and Interventions Targeting the Retinal Ganglion Cell Axon. J Vis Exp. 2020 09 06; (163). Do JL, Allahwerdy S, David RC, Weinreb RN, Welsbie DS. PMID: 32955495.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Potential of Ocular Transmission of SARS-CoV-2: A Review. Vision (Basel). 2020 Sep 01; 4(3). Barnett BP, Wahlin K, Krawczyk M, Spencer D, Welsbie D, Afshari N, Chao D. PMID: 32883010.
      View in: PubMed   Mentions:
    5. A Randomized Controlled Trial Comparing Subconjunctival Injection to Direct Scleral Application of Mitomycin C in Trabeculectomy. Am J Ophthalmol. 2020 12; 220:45-52. Do JL, Xu BY, Wong B, Camp A, Ngai P, Long C, Proudfoot J, Moghimi S, Yan D, Welsbie DS, Weinreb RN. PMID: 32645310.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Genetically Encodable Contrast Agents for Optical Coherence Tomography. ACS Nano. 2020 07 28; 14(7):7823-7831. Lu GJ, Chou LD, Malounda D, Patel AK, Welsbie DS, Chao DL, Ramalingam T, Shapiro MG. PMID: 32023037.
      View in: PubMed   Mentions: 2     Fields:    
    7. Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury. Mol Neurodegener. 2019 11 27; 14(1):44. Welsbie DS, Ziogas NK, Xu L, Kim BJ, Ge Y, Patel AK, Ryu J, Lehar M, Alexandris AS, Stewart N, Zack DJ, Koliatsos VE. PMID: 31775817.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma. Cochrane Database Syst Rev. 2019 04 19; 4:CD011875. Foo VHX, Htoon HM, Welsbie DS, Perera SA. PMID: 30999387.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Thyroid hormone signaling specifies cone subtypes in human retinal organoids. Science. 2018 10 12; 362(6411). Eldred KC, Hadyniak SE, Hussey KA, Brenerman B, Zhang PW, Chamling X, Sluch VM, Welsbie DS, Hattar S, Taylor J, Wahlin K, Zack DJ, Johnston RJ. PMID: 30309916.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    10. Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury. Exp Eye Res. 2018 06; 171:54-61. Fernandes KA, Mitchell KL, Patel A, Marola OJ, Shrager P, Zack DJ, Libby RT, Welsbie DS. PMID: 29526794.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells. Stem Cells Transl Med. 2017 11; 6(11):1972-1986. Sluch VM, Chamling X, Liu MM, Berlinicke CA, Cheng J, Mitchell KL, Welsbie DS, Zack DJ. PMID: 29024560.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron. 2017 Jun 21; 94(6):1142-1154.e6. Welsbie DS, Mitchell KL, Jaskula-Ranga V, Sluch VM, Yang Z, Kim J, Buehler E, Patel A, Martin SE, Zhang PW, Ge Y, Duan Y, Fuller J, Kim BJ, Hamed E, Chamling X, Lei L, Fraser IDC, Ronai ZA, Berlinicke CA, Zack DJ. PMID: 28641113.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    13. Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells. Exp Eye Res. 2016 10; 151:61-7. Langouet-Astrie CJ, Yang Z, Polisetti SM, Welsbie DS, Hauswirth WW, Zack DJ, Merbs SL, Enke RA. PMID: 27481653.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6927-36. Wei Y, Gong J, Xu Z, Thimmulappa RK, Mitchell KL, Welsbie DS, Biswal S, Duh EJ. PMID: 26621751.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS One. 2015; 10(10):e0141137. Quigley HA, Pitha IF, Welsbie DS, Nguyen C, Steinhart MR, Nguyen TD, Pease ME, Oglesby EN, Berlinicke CA, Mitchell KL, Kim J, Jefferys JJ, Kimball EC. PMID: 26505191.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    16. Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion. J Neurochem. 2015 Apr; 133(2):233-41. Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ. PMID: 25683606.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. More than just optic disc swelling. JAMA Ophthalmol. 2013 Nov; 131(11):1477-8. PMID: 24232085.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions. Future Med Chem. 2013 Oct; 5(16):1923-34. PMID: 24175744.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):E3425-34. PMID: 23959876.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    20. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4045-50. PMID: 23431148.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    21. Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 02; 479(7371):67-73. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. PMID: 22051675.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    22. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009 May 08; 324(5928):787-90. Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL. PMID: 19359544.
      View in: PubMed   Mentions: 649     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    23. Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer Res. 2009 Feb 01; 69(3):958-66. Welsbie DS, Xu J, Chen Y, Borsu L, Scher HI, Rosen N, Sawyers CL. PMID: 19176386.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    24. Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3100-5. Baek SH, Ohgi KA, Nelson CA, Welsbie D, Chen C, Sawyers CL, Rose DW, Rosenfeld MG. PMID: 16492776.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    25. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006 Jan; 12(1):122-7. Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL. PMID: 16341243.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    26. Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. J Neurosci. 2004 Nov 24; 24(47):10603-15. Khan AM, Cheung HH, Gillard ER, Palarca JA, Welsbie DS, Gurd JW, Stanley BG. PMID: 15564576.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    27. Molecular determinants of resistance to antiandrogen therapy. Nat Med. 2004 Jan; 10(1):33-9. Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, Rosenfeld MG, Sawyers CL. PMID: 14702632.
      View in: PubMed   Mentions: 809     Fields:    Translation:HumansCells
    28. Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein. J Biol Chem. 1999 Aug 27; 274(35):24787-98. Watson AD, Subbanagounder G, Welsbie DS, Faull KF, Navab M, Jung ME, Fogelman AM, Berliner JA. PMID: 10455151.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
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