Derek Welsbie

Title(s)Associate Professor, Ophthalmology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Kinase Multitargeting for Glaucoma Neuroprotection
    NIH R01EY029342Sep 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    An RNAi Screen for Genes that Modulate Retinal Ganglion Cell Survival
    NIH R21EY022769Sep 1, 2012 - Aug 31, 2014
    Role: Co-Principal Investigator
    High-content high-throughput functional genomics in retinal ganglion cells
    NIH K08EY022078Dec 1, 2011 - Nov 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration. Nat Commun. 2025 Feb 20; 16(1):1789. Liu D, Webber HC, Bian F, Xu Y, Prakash M, Feng X, Yang M, Yang H, You IJ, Li L, Liu L, Liu P, Huang H, Chang CY, Liu L, Shah SH, La Torre A, Welsbie DS, Sun Y, Duan X, Goldberg JL, Braun M, Lansky Z, Hu Y. PMID: 39979261; PMCID: PMC11842812.
      View in: PubMed   Mentions:    Fields:    
    2. Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers. bioRxiv. 2024 Dec 25. Lum MR, Patel SH, Graham HK, Zhao M, Yi Y, Li L, Yao M, La Torre A, Santina LD, Han Y, Hu Y, Welsbie DS, Duan X. PMID: 39763956; PMCID: PMC11703203.
      View in: PubMed   Mentions:
    3. Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration. bioRxiv. 2024 Apr 03. Liu D, Webber HC, Bian F, Xu Y, Prakash M, Feng X, Yang M, Yang H, You IJ, Li L, Liu L, Liu P, Huang H, Chang CY, Liu L, Shah SH, Torre A, Welsbie DS, Sun Y, Duan X, Goldberg JL, Braun M, Lansky Z, Hu Y. PMID: 38617277; PMCID: PMC11014509.
      View in: PubMed   Mentions:
    4. Mechanical Disruption of the Inner Limiting Membrane In Vivo Enhances Targeting to the Inner Retina. Invest Ophthalmol Vis Sci. 2023 Dec 01; 64(15):25. Do JL, Pedroarena-Leal N, Louie M, Avila Garcia P, Alnihmy A, Patel A, Weinreb RN, Wahlin KJ, La Torre Vila A, Welsbie DS. PMID: 38117244; PMCID: PMC10741092.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming. NPJ Regen Med. 2023 Sep 29; 8(1):55. Agarwal D, Dash N, Mazo KW, Chopra M, Avila MP, Patel A, Wong RM, Jia C, Do H, Cheng J, Chiang C, Jurlina SL, Roshan M, Perry MW, Rho JM, Broyer R, Lee CD, Weinreb RN, Gavrilovici C, Oesch NW, Welsbie DS, Wahlin KJ. PMID: 37773257; PMCID: PMC10541876.
      View in: PubMed   Mentions: 3  
    6. Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Mol Neurodegener. 2023 09 21; 18(1):64. Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J, RReSTORe Consortium, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV. PMID: 37735444; PMCID: PMC10514988.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy. Cell Rep. 2023 09 26; 42(9):113038. Zhao M, Toma K, Kinde B, Li L, Patel AK, Wu KY, Lum MR, Tan C, Hooper JE, Kriegstein AR, La Torre A, Liao YJ, Welsbie DS, Hu Y, Han Y, Duan X. PMID: 37624696; PMCID: PMC10591811.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. Traumatic Axonal Injury in the Optic Nerve: The Selective Role of SARM1 in the Evolution of Distal Axonopathy. J Neurotrauma. 2023 08; 40(15-16):1743-1761. Alexandris AS, Lee Y, Lehar M, Alam Z, McKenney J, Perdomo D, Ryu J, Welsbie D, Zack DJ, Koliatsos VE. PMID: 36680758; PMCID: PMC10460965.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. Usability and Clinician Acceptance of a Deep Learning-Based Clinical Decision Support Tool for Predicting Glaucomatous Visual Field Progression. J Glaucoma. 2023 03 01; 32(3):151-158. Chen JS, Baxter SL, van den Brandt A, Lieu A, Camp AS, Do JL, Welsbie DS, Moghimi S, Christopher M, Weinreb RN, Zangwill LM. PMID: 36877820; PMCID: PMC9996451.
      View in: PubMed   Mentions: 1     Fields:    
    10. A Deep Learning Approach to Improve Retinal Structural Predictions and Aid Glaucoma Neuroprotective Clinical Trial Design. Ophthalmol Glaucoma. 2023 Mar-Apr; 6(2):147-159. Christopher M, Hoseini P, Walker E, Proudfoot JA, Bowd C, Fazio MA, Girkin CA, De Moraes CG, Liebmann JM, Weinreb RN, Schwartzman A, Zangwill LM, Welsbie DS. PMID: 36038107.
      View in: PubMed   Mentions: 4     Fields:    
    11. Live, die, or regenerate? New insights from multi-omic analyses. Neuron. 2022 08 17; 110(16):2516-2519. Tsai NY, Welsbie DS, Duan X. PMID: 35981522; PMCID: PMC9521179.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Polymorphous low-grade adenocarcinoma with cavernous sinus involvement presenting as third nerve palsy. Am J Ophthalmol Case Rep. 2022 Jun; 26:101460. Chan AX, Chang A, Do JL, Koo SJ, Lin G, Welsbie DS. PMID: 35313474; PMCID: PMC8933825.
      View in: PubMed   Mentions:
    13. Superior segmental optic nerve hypoplasia: A review. Surv Ophthalmol. 2022 Sep-Oct; 67(5):1467-1475. Wu JH, Lin CW, Liu CH, Weinreb RN, Welsbie DS. PMID: 35189184.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Optic Nerve Engraftment of Neural Stem Cells. Invest Ophthalmol Vis Sci. 2021 07 01; 62(9):30. Do JL, Allahwerdy S, David RCC, Weinreb RN, Tuszynski MH, Welsbie DS. PMID: 34283208; PMCID: PMC8300061.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Qualitative Evaluation of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma. Am J Ophthalmol. 2021 09; 229:26-33. Orbach A, Ang GS, Camp AS, Welsbie DS, Medeiros FA, Girkin CA, Fazio MA, Oh WH, Weinreb RN, Zangwill LM, Wu Z. PMID: 33626360; PMCID: PMC8379296.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Progressive Thinning of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in Glaucoma Eyes with Disc Hemorrhage. Ophthalmol Glaucoma. 2021 Sep-Oct; 4(5):541-549. Liu X, Lau A, Hou H, Moghimi S, Proudfoot JA, Chan E, Do J, Camp A, Welsbie D, Gustavo de Moraes C, Girkin CA, Liebmann JM, Weinreb RN. PMID: 33529795; PMCID: PMC8322143.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33597-33607. Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS. PMID: 33318207; PMCID: PMC7777023.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. Sheath-Preserving Optic Nerve Transection in Rats to Assess Axon Regeneration and Interventions Targeting the Retinal Ganglion Cell Axon. J Vis Exp. 2020 09 06; (163). Do JL, Allahwerdy S, David RC, Weinreb RN, Welsbie DS. PMID: 32955495; PMCID: PMC9283713.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Potential of Ocular Transmission of SARS-CoV-2: A Review. Vision (Basel). 2020 Sep 01; 4(3). Barnett BP, Wahlin K, Krawczyk M, Spencer D, Welsbie D, Afshari N, Chao D. PMID: 32883010; PMCID: PMC7559808.
      View in: PubMed   Mentions: 24  
    20. A Randomized Controlled Trial Comparing Subconjunctival Injection to Direct Scleral Application of Mitomycin C in Trabeculectomy. Am J Ophthalmol. 2020 12; 220:45-52. Do JL, Xu BY, Wong B, Camp A, Ngai P, Long C, Proudfoot J, Moghimi S, Yan D, Welsbie DS, Weinreb RN. PMID: 32645310; PMCID: PMC7717496.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Genetically Encodable Contrast Agents for Optical Coherence Tomography. ACS Nano. 2020 07 28; 14(7):7823-7831. Lu GJ, Chou LD, Malounda D, Patel AK, Welsbie DS, Chao DL, Ramalingam T, Shapiro MG. PMID: 32023037; PMCID: PMC7685218.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    22. Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury. Mol Neurodegener. 2019 11 27; 14(1):44. Welsbie DS, Ziogas NK, Xu L, Kim BJ, Ge Y, Patel AK, Ryu J, Lehar M, Alexandris AS, Stewart N, Zack DJ, Koliatsos VE. PMID: 31775817; PMCID: PMC6882250.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma. Cochrane Database Syst Rev. 2019 04 19; 4:CD011875. Foo VHX, Htoon HM, Welsbie DS, Perera SA. PMID: 30999387; PMCID: PMC6472957.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    24. Thyroid hormone signaling specifies cone subtypes in human retinal organoids. Science. 2018 10 12; 362(6411). Eldred KC, Hadyniak SE, Hussey KA, Brenerman B, Zhang PW, Chamling X, Sluch VM, Welsbie DS, Hattar S, Taylor J, Wahlin K, Zack DJ, Johnston RJ. PMID: 30309916; PMCID: PMC6249681.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    25. Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury. Exp Eye Res. 2018 06; 171:54-61. Fernandes KA, Mitchell KL, Patel A, Marola OJ, Shrager P, Zack DJ, Libby RT, Welsbie DS. PMID: 29526794; PMCID: PMC5964014.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    26. Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells. Stem Cells Transl Med. 2017 11; 6(11):1972-1986. Sluch VM, Chamling X, Liu MM, Berlinicke CA, Cheng J, Mitchell KL, Welsbie DS, Zack DJ. PMID: 29024560; PMCID: PMC6430043.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    27. Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron. 2017 Jun 21; 94(6):1142-1154.e6. Welsbie DS, Mitchell KL, Jaskula-Ranga V, Sluch VM, Yang Z, Kim J, Buehler E, Patel A, Martin SE, Zhang PW, Ge Y, Duan Y, Fuller J, Kim BJ, Hamed E, Chamling X, Lei L, Fraser IDC, Ronai ZA, Berlinicke CA, Zack DJ. PMID: 28641113; PMCID: PMC5553555.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    28. Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells. Exp Eye Res. 2016 10; 151:61-7. Langouet-Astrie CJ, Yang Z, Polisetti SM, Welsbie DS, Hauswirth WW, Zack DJ, Merbs SL, Enke RA. PMID: 27481653.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    29. Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6927-36. Wei Y, Gong J, Xu Z, Thimmulappa RK, Mitchell KL, Welsbie DS, Biswal S, Duh EJ. PMID: 26621751; PMCID: PMC4687549.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    30. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS One. 2015; 10(10):e0141137. Quigley HA, Pitha IF, Welsbie DS, Nguyen C, Steinhart MR, Nguyen TD, Pease ME, Oglesby EN, Berlinicke CA, Mitchell KL, Kim J, Jefferys JJ, Kimball EC. PMID: 26505191; PMCID: PMC4624713.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    31. Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion. J Neurochem. 2015 Apr; 133(2):233-41. Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ. PMID: 25683606; PMCID: PMC4413918.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    32. More than just optic disc swelling. JAMA Ophthalmol. 2013 Nov; 131(11):1477-8. Channa R, Welsbie DS, Patel VR. PMID: 24232085.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions. Future Med Chem. 2013 Oct; 5(16):1923-34. Ferraris D, Yang Z, Welsbie D. PMID: 24175744.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    34. Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):E3425-34. Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A. PMID: 23959876; PMCID: PMC3767527.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    35. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4045-50. Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ. PMID: 23431148; PMCID: PMC3593842.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    36. Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 02; 479(7371):67-73. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. PMID: 22051675; PMCID: PMC3270891.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    37. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009 May 08; 324(5928):787-90. Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL. PMID: 19359544; PMCID: PMC2981508.
      View in: PubMed   Mentions: 979     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    38. Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer Res. 2009 Feb 01; 69(3):958-66. Welsbie DS, Xu J, Chen Y, Borsu L, Scher HI, Rosen N, Sawyers CL. PMID: 19176386; PMCID: PMC3219545.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimals
    39. Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3100-5. Baek SH, Ohgi KA, Nelson CA, Welsbie D, Chen C, Sawyers CL, Rose DW, Rosenfeld MG. PMID: 16492776; PMCID: PMC1413901.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    40. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006 Jan; 12(1):122-7. Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL. PMID: 16341243.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    41. Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. J Neurosci. 2004 Nov 24; 24(47):10603-15. Khan AM, Cheung HH, Gillard ER, Palarca JA, Welsbie DS, Gurd JW, Stanley BG. PMID: 15564576; PMCID: PMC6730118.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    42. Molecular determinants of resistance to antiandrogen therapy. Nat Med. 2004 Jan; 10(1):33-9. Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, Rosenfeld MG, Sawyers CL. PMID: 14702632.
      View in: PubMed   Mentions: 998     Fields:    Translation:HumansCells
    43. Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein. J Biol Chem. 1999 Aug 27; 274(35):24787-98. Watson AD, Subbanagounder G, Welsbie DS, Faull KF, Navab M, Jung ME, Fogelman AM, Berliner JA. PMID: 10455151.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
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