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Optic Nerve Engraftment of Neural Stem Cells. Invest Ophthalmol Vis Sci. 2021 Jul 01; 62(9):30.
Do JL, Allahwerdy S, David RCC, Weinreb RN, Tuszynski MH, Welsbie DS. PMID: 34283208.
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Qualitative Evaluation of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma. Am J Ophthalmol. 2021 Feb 21; 229:26-33.
Orbach A, Ang GS, Camp AS, Welsbie DS, Medeiros FA, Girkin CA, Fazio MA, Oh WH, Weinreb RN, Zangwill LM, Wu Z. PMID: 33626360.
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Progressive Thinning of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in Glaucoma Eyes with Disc Hemorrhage. Ophthalmol Glaucoma. 2021 Jan 30.
Liu X, Lau A, Hou H, Moghimi S, Proudfoot JA, Chan E, Do J, Camp A, Welsbie D, Gustavo de Moraes C, Girkin CA, Liebmann JM, Weinreb RN. PMID: 33529795.
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Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33597-33607.
Patel AK, Broyer RM, Lee CD, Lu T, Louie MJ, La Torre A, Al-Ali H, Vu MT, Mitchell KL, Wahlin KJ, Berlinicke CA, Jaskula-Ranga V, Hu Y, Duan X, Vilar S, Bixby JL, Weinreb RN, Lemmon VP, Zack DJ, Welsbie DS. PMID: 33318207.
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4 Fields:
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HumansAnimalsCells
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Sheath-Preserving Optic Nerve Transection in Rats to Assess Axon Regeneration and Interventions Targeting the Retinal Ganglion Cell Axon. J Vis Exp. 2020 09 06; (163).
Do JL, Allahwerdy S, David RC, Weinreb RN, Welsbie DS. PMID: 32955495.
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1 Fields:
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AnimalsCells
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Potential of Ocular Transmission of SARS-CoV-2: A Review. Vision (Basel). 2020 Sep 01; 4(3).
Barnett BP, Wahlin K, Krawczyk M, Spencer D, Welsbie D, Afshari N, Chao D. PMID: 32883010.
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A Randomized Controlled Trial Comparing Subconjunctival Injection to Direct Scleral Application of Mitomycin C in Trabeculectomy. Am J Ophthalmol. 2020 12; 220:45-52.
Do JL, Xu BY, Wong B, Camp A, Ngai P, Long C, Proudfoot J, Moghimi S, Yan D, Welsbie DS, Weinreb RN. PMID: 32645310.
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1 Fields:
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Humans
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Genetically Encodable Contrast Agents for Optical Coherence Tomography. ACS Nano. 2020 07 28; 14(7):7823-7831.
Lu GJ, Chou LD, Malounda D, Patel AK, Welsbie DS, Chao DL, Ramalingam T, Shapiro MG. PMID: 32023037.
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4 Fields:
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Animals
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Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury. Mol Neurodegener. 2019 11 27; 14(1):44.
Welsbie DS, Ziogas NK, Xu L, Kim BJ, Ge Y, Patel AK, Ryu J, Lehar M, Alexandris AS, Stewart N, Zack DJ, Koliatsos VE. PMID: 31775817.
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PubMed Mentions:
2 Fields:
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AnimalsCells
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Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma. Cochrane Database Syst Rev. 2019 04 19; 4:CD011875.
Foo VHX, Htoon HM, Welsbie DS, Perera SA. PMID: 30999387.
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PubMed Mentions:
5 Fields:
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Humans
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Thyroid hormone signaling specifies cone subtypes in human retinal organoids. Science. 2018 10 12; 362(6411).
Eldred KC, Hadyniak SE, Hussey KA, Brenerman B, Zhang PW, Chamling X, Sluch VM, Welsbie DS, Hattar S, Taylor J, Wahlin K, Zack DJ, Johnston RJ. PMID: 30309916.
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43 Fields:
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HumansCells
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Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury. Exp Eye Res. 2018 06; 171:54-61.
Fernandes KA, Mitchell KL, Patel A, Marola OJ, Shrager P, Zack DJ, Libby RT, Welsbie DS. PMID: 29526794.
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18 Fields:
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AnimalsCells
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Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells. Stem Cells Transl Med. 2017 11; 6(11):1972-1986.
Sluch VM, Chamling X, Liu MM, Berlinicke CA, Cheng J, Mitchell KL, Welsbie DS, Zack DJ. PMID: 29024560.
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23 Fields:
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HumansCells
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Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron. 2017 Jun 21; 94(6):1142-1154.e6.
Welsbie DS, Mitchell KL, Jaskula-Ranga V, Sluch VM, Yang Z, Kim J, Buehler E, Patel A, Martin SE, Zhang PW, Ge Y, Duan Y, Fuller J, Kim BJ, Hamed E, Chamling X, Lei L, Fraser IDC, Ronai ZA, Berlinicke CA, Zack DJ. PMID: 28641113.
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40 Fields:
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HumansAnimalsCells
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Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells. Exp Eye Res. 2016 10; 151:61-7.
Langouet-Astrie CJ, Yang Z, Polisetti SM, Welsbie DS, Hauswirth WW, Zack DJ, Merbs SL, Enke RA. PMID: 27481653.
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AnimalsCells
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Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):E6927-36.
Wei Y, Gong J, Xu Z, Thimmulappa RK, Mitchell KL, Welsbie DS, Biswal S, Duh EJ. PMID: 26621751.
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21 Fields:
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AnimalsCells
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Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS One. 2015; 10(10):e0141137.
Quigley HA, Pitha IF, Welsbie DS, Nguyen C, Steinhart MR, Nguyen TD, Pease ME, Oglesby EN, Berlinicke CA, Mitchell KL, Kim J, Jefferys JJ, Kimball EC. PMID: 26505191.
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PubMed Mentions:
23 Fields:
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HumansAnimalsCells
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Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion. J Neurochem. 2015 Apr; 133(2):233-41.
Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ. PMID: 25683606.
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27 Fields:
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AnimalsCells
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More than just optic disc swelling. JAMA Ophthalmol. 2013 Nov; 131(11):1477-8.
Channa R, Welsbie DS, Patel VR. PMID: 24232085.
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HumansCells
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Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions. Future Med Chem. 2013 Oct; 5(16):1923-34.
Ferraris D, Yang Z, Welsbie D. PMID: 24175744.
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7 Fields:
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HumansAnimalsCells
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Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):E3425-34.
Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A. PMID: 23959876.
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49 Fields:
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HumansAnimalsCells
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Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):4045-50.
Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ. PMID: 23431148.
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107 Fields:
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HumansAnimalsCells
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Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 02; 479(7371):67-73.
Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. PMID: 22051675.
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103 Fields:
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AnimalsCells
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Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009 May 08; 324(5928):787-90.
Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL. PMID: 19359544.
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Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer Res. 2009 Feb 01; 69(3):958-66.
Welsbie DS, Xu J, Chen Y, Borsu L, Scher HI, Rosen N, Sawyers CL. PMID: 19176386.
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65 Fields:
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HumansAnimals
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Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3100-5.
Baek SH, Ohgi KA, Nelson CA, Welsbie D, Chen C, Sawyers CL, Rose DW, Rosenfeld MG. PMID: 16492776.
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PubMed Mentions:
34 Fields:
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HumansAnimalsCells
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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006 Jan; 12(1):122-7.
Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL. PMID: 16341243.
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PubMed Mentions:
209 Fields:
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HumansAnimalsCells
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Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. J Neurosci. 2004 Nov 24; 24(47):10603-15.
Khan AM, Cheung HH, Gillard ER, Palarca JA, Welsbie DS, Gurd JW, Stanley BG. PMID: 15564576.
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PubMed Mentions:
9 Fields:
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AnimalsCells
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Molecular determinants of resistance to antiandrogen therapy. Nat Med. 2004 Jan; 10(1):33-9.
Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, Rosenfeld MG, Sawyers CL. PMID: 14702632.
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PubMed Mentions:
878 Fields:
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HumansCells
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Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein. J Biol Chem. 1999 Aug 27; 274(35):24787-98.
Watson AD, Subbanagounder G, Welsbie DS, Faull KF, Navab M, Jung ME, Fogelman AM, Berliner JA. PMID: 10455151.
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PubMed Mentions:
52 Fields:
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HumansCells