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Hoi U

Photo of Hoi U
Title(s)Emeritus Professor, Neurological Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dr. Hoi Sang U joined the faculty of UCSD in 1978. Dr. U, serving as Professor of Neurological Surgery, was appointed the Vice-Chief of Academic Affairs for the division of Neurological Surgery in 1995. He has an extensive background in all aspects of neurosurgery, including neurovascular, skull base, and transsphenoidal surgery.

    Dr. U is an internationally recognized specialist in the treatment of the vascular anomalies known as AVMs. Patients have traveled to UCSD from as far away as Australia, Hong Kong, and the Sultanate of Brunei to take advantage of his expertise. His neurovascular practice also includes treatment of aneurysms and cavernous hemangiomas. He collaborates closely with interventional neuroradiologists Dr. Charles Kerber and Dr. Wade Wong to provide a complete program of diagnosis and treatment.

    Dr. U's other surgical interests include treatment of brain masses, including meningiomas, astrocytomas, craniopharyngiomas, and pituitary adenomas.

    Dr. U is a renowned expert in brain tumor research. Throughout his research career, he has been entrusted with millions of dollars worth of neurosurgical research grants. He has conducted studies on diseases ranging from human pituitary adenomas to glioblastomas and is pioneering work in gene therapy and brain tissue transplantation.

    Dr. U earned his undergraduate degree from Yale University and his medical degree from Tufts Medical School in Boston, Massachusetts. He completed his residency training at the University of California, San Francisco (UCSF) Medical Center under world-renowned neurosurgeon Dr. Charles B. Wilson. Dr. U has served as the Chief of Neurosurgical Services at the Veterans Administration Medical Center in San Diego since 1983.

    Dr. U has served on numerous scientific and professional committees. Dr. U has been invited as a distinguished lecturer or panelist at over 100 meetings and conferences. He is also a member of numerous scientific and professional societies, including the American Association of Neurological Surgeons, San Diego Academy of Neurological Surgeons, Congress of Neurological Surgeons, and the North American Skull Base Society.

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    HUMAN PITUITARY ADENOMAS: ISOLATION AND CHARACTERIZATION
    NIH K07NS000694Jul 1, 1983 - Jun 30, 1988
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Scalable Fishbone Nanowire Array (FINE) for 3D Quasi-Intracellular Recording in Intact Brains. Adv Mater. 2025 Oct; 37(41):e04171. Tchoe Y, Lee J, Tonsfeldt KJ, Wu T, Cleary DR, U HS, Liu R, Bouvier G, Vatsyayan R, Bourhis AM, Lee SH, Halgren E, Galton I, Scanziani M, Dayeh SA. PMID: 40697101.
      View in: PubMed   Mentions:    Fields:    
    2. The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma. bioRxiv. 2025 May 19. Tharp ME, Han CZ, Talukdar M, Balak CD, Fitzpatrick C, Connor CO, Preissl S, Buchanan J, Nott A, Escoubet L, Mavrommatis K, Gupta M, Schwartz MS, U HS, Jones PS, Levy ML, Gonda DD, Ben-Haim S, Ciacci J, Barba D, Khalessi A, Coufal NG, Chen CC, Glass CK, Page DC. PMID: 38895459; PMCID: PMC11185629.
      View in: PubMed   Mentions:
    3. An electroencephalogram microdisplay to visualize neuronal activity on the brain surface. Sci Transl Med. 2024 04 24; 16(744):eadj7257. Tchoe Y, Wu T, U HS, Roth DM, Kim D, Lee J, Cleary DR, Pizarro P, Tonsfeldt KJ, Lee K, Chen PC, Bourhis AM, Galton I, Coughlin B, Yang JC, Paulk AC, Halgren E, Cash SS, Dayeh SA. PMID: 38657026; PMCID: PMC11093107.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. The Brain Electroencephalogram Microdisplay for Precision Neurosurgery. bioRxiv. 2023 Jul 21. Tchoe Y, Wu T, U HS, Roth DM, Kim D, Lee J, Cleary DR, Pizarro P, Tonsfeldt KJ, Lee K, Chen PC, Bourhis AM, Galton I, Coughlin B, Yang JC, Paulk AC, Halgren E, Cash SS, Dayeh SA. PMID: 37503216; PMCID: PMC10370209.
      View in: PubMed   Mentions:
    5. Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces. MRS Bull. 2023 May; 48(5):531-546. Vatsyayan R, Lee J, Bourhis AM, Tchoe Y, Cleary DR, Tonsfeldt KJ, Lee K, Montgomery-Walsh R, Paulk AC, U HS, Cash SS, Dayeh SA. PMID: 37476355; PMCID: PMC10357958.
      View in: PubMed   Mentions: 5  
    6. Role of SOCS and VHL Proteins in Neuronal Differentiation and Development. Int J Mol Sci. 2023 Feb 15; 24(4). Kanno H, Matsumoto S, Yoshizumi T, Nakahara K, Kubo A, Murata H, Shuin T, U HS. PMID: 36835292; PMCID: PMC9960776.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Inguinal Extrusion of a Ventriculoperitoneal Shunt. World Neurosurg. 2020 06; 138:242-245. Mazza J, Brandel MG, Steinberg JA, U HS. PMID: 32179187.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Transient Aphasia Following Resection of a Thalamic Cavernous Malformation. World Neurosurg. 2020 Apr; 136:390-393.e3. Brandel MG, Lee RR, U HS. PMID: 32004743.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Strongyloides stercoralis Hyperinfection Syndrome Presenting as Severe, Recurrent Gastrointestinal Bleeding, Leading to a Diagnosis of Cushing Disease. Am J Trop Med Hyg. 2015 Oct; 93(4):822-7. Yee B, Chi NW, Hansen LA, Lee RR, U HS, Savides TJ, Vinetz JM. PMID: 26195463; PMCID: PMC4596606.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    10. Transdifferentiation of rat fetal brain stem cells into penile smooth muscle cells. BJU Int. 2009 Jul; 104(2):257-62. Song Y, Mehta N, Sheh B, Saljooque F, U HS, Rajasekaran M. PMID: 19220248.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Brain tumor stem cells and the tumor microenvironmen. Neurosurg Focus. 2008; 24(3-4):E27. Jandial R, U H, Levy ML, Snyder EY. PMID: 18341404.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Selective differentiation of central nervous system-derived stem cells in response to cues from specific regions of the developing brain. J Neurosurg. 2007 Jul; 107(1):145-54. Vorasubin B, Weedin J, Saljooque F, Wilkes N, Eng M, U HS. PMID: 17639884.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. Brain stem cells adopt a pituitary fate after implantation into the adult rodent pituitary gland. Neuroendocrinology. 2007; 86(1):58-68. U HS, Wu B, Wilkes N, Ho A, Saljooque F. PMID: 17587785.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Evolution of the human brain: changing brain size and the fossil record. Neurosurgery. 2007 Mar; 60(3):555-62; discussion 562. Park MS, Nguyen AD, Aryan HE, U HS, Levy ML, Semendeferi K. PMID: 17327801.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Intraoperative brain ultrasound: a new approach to study flow dynamics in intracranial aneurysms. Ultrasound Med Biol. 2006 Sep; 32(9):1307-13. Hölscher T, Rodriguez-Rodriguez J, Wilkening WG, Lasheras JC, U HS. PMID: 16965970.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Growth factor gene therapy for Alzheimer disease. Neurosurg Focus. 2002 Nov 15; 13(5):e5. Tuszynski MH, U HS, Alksne J, Bakay RA, Pay MM, Merrill D, Thal LJ. PMID: 15769074.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    17. Fetal brain progenitor cells transdifferentiate to fates outside the nervous system. Mol Endocrinol. 2002 Nov; 16(11):2645-56. U HS, Alilain W, Saljooque F. PMID: 12403852.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Alteration in p53 modulates glial proteins in human glial tumour cells. J Neurooncol. 2000 Jul; 48(3):191-206. U HS, Banaie A, Rigby L, Chen J, Meltzer H. PMID: 11100817.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
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