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John Alksne

TitleRecall Hcomp
InstitutionUniversity of California San Diego
DepartmentSurgery
Address9500 Gilman Drive #0973
La Jolla CA 92093
Phone858-657-7920
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    Collapse Overview 
    Collapse Overview
    Dr. John F. Alksne, a distinguished neurosurgeon and highly respected researcher in neurological disease, joined the UC San Diego Neurosurgery faculty in 1971 as a Professor of Neurological Surgery. Dr. Alksne served as Chief of Neurological Surgery at UC San Diego until 1995. He was appointed dean of the UC San Diego School of Medicine in 1992 and appointed Vice Chancellor for Health Sciences in 1994.

    Dr. Alksne's clinical practice focuses on the care of patients suffering from trigeminal neuralgia (tic doloreux), facial tic, glossopharyngeal neuralgia, spasmodic torticollis, epilepsy, and acoustic neuroma.

    Throughout his career, Dr. Alksne has pioneered new surgical techniques and technologies to advance the treatment of diseases and disorders of the central nervous system. He established and directs the Epilepsy Surgery Program at UC San Diego, and in 1992 was honored with a Special Commendation by the Epilepsy society of San Diego County. As Dean, he has been instrumental in establishing the UC San Diego Program in Gene Therapy, which includes research, training and clinical trials in the promising new field of gene therapy.

    Dr. Alksne earned his medical degree at the University of Washington in Seattle, where he also completed his training. He was Chief of Neurosurgery at Harbor General Hospital at UCLA from 1964-67, and Professor and Chair of Neurological Surgery at the Medical College of Virginia from 1967-71.

    He is a member of numerous scientific and professional societies, including the American Association of Neurological Surgeons, the Latin American Federal of Neurosurgeons, the World Society of Stereotactic and Functional Neurosurgery, the Association of American Medical Colleges, and the Association of Academic Health Centers.

    Diseases/Research Topics
    Glioma, Malignant Glioma

    Research Interests
    Intra-tumoral infusion for malignant glioma, conducted in both clinical trials and in animal experimentation.


    Collapse Research 
    Collapse Research Activities and Funding
    BRAIN PROTECTION DURING HYPOTHERMIC CIRCULATORY ARREST
    NIH/NINDS R01NS028450Aug 1, 1992 - Jul 31, 1996
    Role: Principal Investigator
    NEUROSURGERY RESEARCH TRAINING GRANT
    NIH/NINDS T32NS007342Jul 1, 1991 - Jun 30, 1997
    Role: Principal Investigator
    PREVENTION OF INTRACRANIAL ARTERIAL REACTION TO SAH
    NIH/NINDS R01NS018522Sep 1, 1982 - Nov 30, 1988
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Steinberg JA, Sack J, Wilson B, Weingarten D, Carter B, Khalessi A, Ben-Haim S, Alksne J. Tentorial sling for microvascular decompression in patients with trigeminal neuralgia: a description of operative technique and clinical outcomes. J Neurosurg. 2018 Apr 20; 1-6. PMID: 29676696.
      View in: PubMed
    2. Ali MA, Hirshman BR, Wilson B, Schupper AJ, Joshi R, Proudfoot JA, Goetsch SJ, Alksne JF, Ott K, Aiyama H, Nagano O, Carter BS, Chiang V, Serizawa T, Yamamoto M, Chen CC. Improving the Prognostic Value of Disease-Specific Graded Prognostic Assessment Model for Renal Cell Carcinoma by Incorporation of Cumulative Intracranial Tumor Volume. World Neurosurg. 2017 Dec; 108:151-156. PMID: 28754641.
      View in: PubMed
    3. Ali MA, Hirshman BR, Wilson B, Carroll KT, Proudfoot JA, Goetsch SJ, Alksne JF, Ott K, Aiyama H, Nagano O, Carter BS, Fogarty G, Hong A, Serizawa T, Yamamoto M, Chen CC. Survival Patterns of 5750 Stereotactic Radiosurgery-Treated Patients with Brain Metastasis as a Function of the Number of Lesions. World Neurosurg. 2017 Nov; 107:944-951.e1. PMID: 28735121.
      View in: PubMed
    4. Marshall DC, Marcus LP, Kim TE, McCutcheon BA, Goetsch SJ, Koiso T, Alksne JF, Ott K, Carter BS, Hattangadi-Gluth JA, Yamamoto M, Chen CC. Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries. J Neurooncol. 2016 05; 128(1):119-128. PMID: 26948673.
      View in: PubMed
    5. Taich ZJ, Goetsch SJ, Monaco E, Carter BS, Ott K, Alksne JF, Chen CC. Stereotactic Radiosurgery Treatment of Trigeminal Neuralgia: Clinical Outcomes and Prognostic Factors. World Neurosurg. 2016 Jun; 90:604-612.e11. PMID: 26915701.
      View in: PubMed
    6. Gonda DD, Kim TE, Goetsch SJ, Kawabe T, Watanabe S, Alksne JF, Hattangadi JA, Nitta M, Ott K, Hodgens DW, Carter BS, Yamamoto M, Chen CC. Prognostic factors for stereotactic radiosurgery-treated patients with cerebral metastasis: implications on randomised control trial design and inter-institutional collaboration. Eur J Cancer. 2014 Apr; 50(6):1148-58. PMID: 24529832.
      View in: PubMed
    7. Waters JD, Rose B, Gonda DD, Scanderbeg DJ, Russell M, Alksne JF, Murphy K, Carter BS, Lawson J, Chen CC. Immediate post-operative brachytherapy prior to irradiation and temozolomide for newly diagnosed glioblastoma. J Neurooncol. 2013 Jul; 113(3):467-77. PMID: 23673513.
      View in: PubMed
    8. Pan H, Cerviño LI, Pawlicki T, Jiang SB, Alksne J, Detorie N, Russell M, Carter BS, Murphy KT, Mundt AJ, Chen C, Lawson JD. Frameless, real-time, surface imaging-guided radiosurgery: clinical outcomes for brain metastases. Neurosurgery. 2012 Oct; 71(4):844-51. PMID: 22989959.
      View in: PubMed
    9. Pan H, Alksne J, Mundt AJ, Murphy KT, Cornell M, Kesari S, Lawson JD. Patterns of imaging failures in glioblastoma patients treated with chemoradiation: a retrospective study. Med Oncol. 2012 Sep; 29(3):2040-5. PMID: 22108847.
      View in: PubMed
    10. Scanderbeg DJ, Alksne JF, Lawson JD, Murphy KT. Novel use of the Contura for high dose rate cranial brachytherapy. Med Dosim. 2011; 36(4):344-6. PMID: 21144735.
      View in: PubMed
    11. Nath SK, Lawson JD, Simpson DR, Vanderspek L, Wang JZ, Alksne JF, Ciacci J, Mundt AJ, Murphy KT. Single-isocenter frameless intensity-modulated stereotactic radiosurgery for simultaneous treatment of multiple brain metastases: clinical experience. Int J Radiat Oncol Biol Phys. 2010 Sep 01; 78(1):91-7. PMID: 20096509.
      View in: PubMed
    12. Nath SK, Lawson JD, Wang JZ, Simpson DR, Newman CB, Alksne JF, Mundt AJ, Murphy KT. Optically-guided frameless linac-based radiosurgery for brain metastases: clinical experience. J Neurooncol. 2010 Mar; 97(1):67-72. PMID: 19701719; PMCID: PMC2814046.
    13. Hayden MG, Tornabene SV, Nguyen A, Thekdi A, Alksne JF. Cerebellopontine angle cyst compressing the vagus nerve: case report. Neurosurgery. 2007 Jun; 60(6):E1150; discussion 1150. PMID: 17538363.
      View in: PubMed
    14. Bradley WG, Bahl G, Alksne JF. Idiopathic normal pressure hydrocephalus may be a "two hit" disease: benign external hydrocephalus in infancy followed by deep white matter ischemia in late adulthood. J Magn Reson Imaging. 2006 Oct; 24(4):747-55. PMID: 16958056.
      View in: PubMed
    15. Aryan HE, Nakaji P, Lu DC, Alksne JF. Multimodality treatment of trigeminal neuralgia: impact of radiosurgery and high resolution magnetic resonance imaging. J Clin Neurosci. 2006 Feb; 13(2):239-44. PMID: 16439132.
      View in: PubMed
    16. Bahl G, White G, Alksne J, Vemuri L, Spear MA. Focal radiation therapy of brain metastases after complete surgical resection. Med Oncol. 2006; 23(3):317-24. PMID: 17018888.
      View in: PubMed
    17. McDonald CR, Norman MA, Tecoma E, Alksne J, Iragui V. Neuropsychological change following gamma knife surgery in patients with left temporal lobe epilepsy: a review of three cases. Epilepsy Behav. 2004 Dec; 5(6):949-57. PMID: 15582844.
      View in: PubMed
    18. McComb JG, Bradley WG, Safar FG, Furtado C, Hurtado C, Ord J, Alksne JF. Is a large hat size hazardous to your health? AJNR Am J Neuroradiol. 2004 Oct; 25(9):1454-5; author reply 1455. PMID: 15502119.
      View in: PubMed
    19. Bradley WG, Safar FG, Furtado C, Hurtado C, Ord J, Alksne JF. Increased intracranial volume: a clue to the etiology of idiopathic normal-pressure hydrocephalus? AJNR Am J Neuroradiol. 2004 Oct; 25(9):1479-84. PMID: 15502125.
      View in: PubMed
    20. Mohana-Borges AV, Imbesi SG, Dietrich R, Alksne J, Amjadi DK. Role of proton magnetic resonance spectroscopy in the diagnosis of gliomatosis cerebri: a unique pattern of normal choline but elevated Myo-inositol metabolite levels. J Comput Assist Tomogr. 2004 Jan-Feb; 28(1):103-5. PMID: 14716242.
      View in: PubMed
    21. Nakaji P, Meltzer HS, Singel SA, Alksne JF. Improvement of aggressive and antisocial behavior after resection of temporal lobe tumors. Pediatrics. 2003 Nov; 112(5):e430. PMID: 14595088.
      View in: PubMed
    22. Petrucci M, Hoh C, Alksne JF. Thalamic hypometabolism in a patient undergoing vagal nerve stimulation seen on F-18 FDG PET imaging. Clin Nucl Med. 2003 Sep; 28(9):784-5. PMID: 12973011.
      View in: PubMed
    23. Tuszynski MH, U HS, Alksne J, Bakay RA, Pay MM, Merrill D, Thal LJ. Growth factor gene therapy for Alzheimer disease. Neurosurg Focus. 2002 Nov 15; 13(5):e5. PMID: 15769074.
      View in: PubMed
    24. Beutler AS, Hsiang JK, Moorhouse DF, Hansen LA, Alksne JF. Pilocytic astrocytoma presenting as an extra-axial tumor in the cerebellopontine angle: case report. Neurosurgery. 1995 Jul; 37(1):125-8. PMID: 8587672.
      View in: PubMed
    25. Wrobel CJ, Meltzer H, Lamond R, Alksne JF. Intraoperative assessment of aneurysm clip placement by intravenous fluorescein angiography. Neurosurgery. 1994 Nov; 35(5):970-3; discussion 973. PMID: 7838352.
      View in: PubMed
    26. Scheller MS, Branson PJ, Cornacchia LG, Alksne JF. A comparison of the effects on neuronal Golgi morphology, assessed with electron microscopy, of cardiopulmonary bypass, low-flow bypass, and circulatory arrest during profound hypothermia. J Thorac Cardiovasc Surg. 1992 Nov; 104(5):1396-404. PMID: 1434722.
      View in: PubMed
    27. Wrobel CJ, Alksne JF. Retromastoid cisternal Ommaya reservoir for intrathecal therapy of coccidioidomycosis meningitis. Technical note. J Neurosurg. 1992 Sep; 77(3):476-7. PMID: 1506899.
      View in: PubMed
    28. Drummond JC, Iragui-Madoz VJ, Alksne JF, Kalkman CJ. Masking of epileptiform activity by propofol during seizure surgery. Anesthesiology. 1992 Apr; 76(4):652-4. PMID: 1550293.
      View in: PubMed
    29. Stompro BE, Alksne JF, Press GA. Diagnosis and treatment of an odontoid fracture in a patient with polyostotic fibrous dysplasia: case report. Neurosurgery. 1989 Jun; 24(6):905-9. PMID: 2747866.
      View in: PubMed
    30. Harris JP, Godin MS, Krekorian TD, Alksne JF. The transoropalatal approach to the atlantoaxial-clival region: considerations for the head and neck surgeon. Laryngoscope. 1989 May; 99(5):467-74. PMID: 2709933.
      View in: PubMed
    31. Alksne JF, Branson PJ, Bailey M. Modification of experimental post-subarachnoid hemorrhage vasculopathy with intracisternal plasmin. Neurosurgery. 1988 Sep; 23(3):335-7. PMID: 2976126.
      View in: PubMed
    32. Healy ME, Hesselink JR, Ostrup RC, Alksne JF. Demonstration by magnetic resonance of symptomatic spinal epidural lipomatosis. Neurosurgery. 1987 Sep; 21(3):414-5. PMID: 3670587.
      View in: PubMed
    33. Barba D, Alksne JF. Success of microvascular decompression with and without prior surgical therapy for trigeminal neuralgia. J Neurosurg. 1984 Jan; 60(1):104-7. PMID: 6689703.
      View in: PubMed
    34. James HE, Wells M, Alksne JF, Wickbom I, Siemers P, Brahme F, Rosenberg J. Needle biopsy under computerized tomographic control: a method for tissue diagnosis in intracranial lesions. Neurosurgery. 1979 Dec; 5(6):671-4. PMID: 534075.
      View in: PubMed
    35. Alksne JF, White LE. Electron-microscope study of the effect of increased intracranial pressure on the arachnoid villus. J Neurosurg. 1965 May; 22(5):481-8. PMID: 5825610.
      View in: PubMed