John Alksne

Title(s)Recall Hcomp, Neurological Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dr. John F. Alksne, a distinguished neurosurgeon and highly respected researcher in neurological disease, joined the UC San Diego Neurosurgery faculty in 1971 as a Professor of Neurological Surgery. Dr. Alksne served as Chief of Neurological Surgery at UC San Diego until 1995. He was appointed dean of the UC San Diego School of Medicine in 1992 and appointed Vice Chancellor for Health Sciences in 1994.

    Dr. Alksne's clinical practice focuses on the care of patients suffering from trigeminal neuralgia (tic doloreux), facial tic, glossopharyngeal neuralgia, spasmodic torticollis, epilepsy, and acoustic neuroma.

    Throughout his career, Dr. Alksne has pioneered new surgical techniques and technologies to advance the treatment of diseases and disorders of the central nervous system. He established and directs the Epilepsy Surgery Program at UC San Diego, and in 1992 was honored with a Special Commendation by the Epilepsy society of San Diego County. As Dean, he has been instrumental in establishing the UC San Diego Program in Gene Therapy, which includes research, training and clinical trials in the promising new field of gene therapy.

    Dr. Alksne earned his medical degree at the University of Washington in Seattle, where he also completed his training. He was Chief of Neurosurgery at Harbor General Hospital at UCLA from 1964-67, and Professor and Chair of Neurological Surgery at the Medical College of Virginia from 1967-71.

    He is a member of numerous scientific and professional societies, including the American Association of Neurological Surgeons, the Latin American Federal of Neurosurgeons, the World Society of Stereotactic and Functional Neurosurgery, the Association of American Medical Colleges, and the Association of Academic Health Centers.

    Diseases/Research Topics
    Glioma, Malignant Glioma

    Research Interests
    Intra-tumoral infusion for malignant glioma, conducted in both clinical trials and in animal experimentation.

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    Collapse Research Activities and Funding
    NIH R01NS028450Aug 1, 1992 - Jul 31, 1996
    Role: Principal Investigator
    NIH T32NS007342Jul 1, 1991 - Jun 30, 1997
    Role: Principal Investigator
    NIH R01NS018522Sep 1, 1982 - Nov 30, 1988
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tentorial sling for microvascular decompression in patients with trigeminal neuralgia: a description of operative technique and clinical outcomes. J Neurosurg. 2018 Apr 01; 1-6. Steinberg JA, Sack J, Wilson B, Weingarten D, Carter B, Khalessi A, Ben-Haim S, Alksne J. PMID: 29676696.
      View in: PubMed   Mentions: 1     Fields:    
    2. Improving the Prognostic Value of Disease-Specific Graded Prognostic Assessment Model for Renal Cell Carcinoma by Incorporation of Cumulative Intracranial Tumor Volume. World Neurosurg. 2017 Dec; 108:151-156. Ali MA, Hirshman BR, Wilson B, Schupper AJ, Joshi R, Proudfoot JA, Goetsch SJ, Alksne JF, Ott K, Aiyama H, Nagano O, Carter BS, Chiang V, Serizawa T, Yamamoto M, Chen CC. PMID: 28754641.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    3. Survival Patterns of 5750 Stereotactic Radiosurgery-Treated Patients with Brain Metastasis as a Function of the Number of Lesions. World Neurosurg. 2017 Nov; 107:944-951.e1. Ali MA, Hirshman BR, Wilson B, Carroll KT, Proudfoot JA, Goetsch SJ, Alksne JF, Ott K, Aiyama H, Nagano O, Carter BS, Fogarty G, Hong A, Serizawa T, Yamamoto M, Chen CC. PMID: 28735121.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries. J Neurooncol. 2016 05; 128(1):119-128. Marshall DC, Marcus LP, Kim TE, McCutcheon BA, Goetsch SJ, Koiso T, Alksne JF, Ott K, Carter BS, Hattangadi-Gluth JA, Yamamoto M, Chen CC. PMID: 26948673.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Stereotactic Radiosurgery Treatment of Trigeminal Neuralgia: Clinical Outcomes and Prognostic Factors. World Neurosurg. 2016 Jun; 90:604-612.e11. Taich ZJ, Goetsch SJ, Monaco E, Carter BS, Ott K, Alksne JF, Chen CC. PMID: 26915701.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    6. Prognostic factors for stereotactic radiosurgery-treated patients with cerebral metastasis: implications on randomised control trial design and inter-institutional collaboration. Eur J Cancer. 2014 Apr; 50(6):1148-58. Gonda DD, Kim TE, Goetsch SJ, Kawabe T, Watanabe S, Alksne JF, Hattangadi JA, Nitta M, Ott K, Hodgens DW, Carter BS, Yamamoto M, Chen CC. PMID: 24529832.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    7. Immediate post-operative brachytherapy prior to irradiation and temozolomide for newly diagnosed glioblastoma. J Neurooncol. 2013 Jul; 113(3):467-77. Waters JD, Rose B, Gonda DD, Scanderbeg DJ, Russell M, Alksne JF, Murphy K, Carter BS, Lawson J, Chen CC. PMID: 23673513.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    8. Frameless, real-time, surface imaging-guided radiosurgery: clinical outcomes for brain metastases. Neurosurgery. 2012 Oct; 71(4):844-51. Pan H, Cerviño LI, Pawlicki T, Jiang SB, Alksne J, Detorie N, Russell M, Carter BS, Murphy KT, Mundt AJ, Chen C, Lawson JD. PMID: 22989959.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    9. Patterns of imaging failures in glioblastoma patients treated with chemoradiation: a retrospective study. Med Oncol. 2012 Sep; 29(3):2040-5. Pan H, Alksne J, Mundt AJ, Murphy KT, Cornell M, Kesari S, Lawson JD. PMID: 22108847.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    10. Novel use of the Contura for high dose rate cranial brachytherapy. Med Dosim. 2011; 36(4):344-6. Scanderbeg DJ, Alksne JF, Lawson JD, Murphy KT. PMID: 21144735.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Single-isocenter frameless intensity-modulated stereotactic radiosurgery for simultaneous treatment of multiple brain metastases: clinical experience. Int J Radiat Oncol Biol Phys. 2010 Sep 01; 78(1):91-7. Nath SK, Lawson JD, Simpson DR, Vanderspek L, Wang JZ, Alksne JF, Ciacci J, Mundt AJ, Murphy KT. PMID: 20096509.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    12. Optically-guided frameless linac-based radiosurgery for brain metastases: clinical experience. J Neurooncol. 2010 Mar; 97(1):67-72. Nath SK, Lawson JD, Wang JZ, Simpson DR, Newman CB, Alksne JF, Mundt AJ, Murphy KT. PMID: 19701719.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    13. Cerebellopontine angle cyst compressing the vagus nerve: case report. Neurosurgery. 2007 Jun; 60(6):E1150; discussion 1150. Hayden MG, Tornabene SV, Nguyen A, Thekdi A, Alksne JF. PMID: 17538363.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Idiopathic normal pressure hydrocephalus may be a "two hit" disease: benign external hydrocephalus in infancy followed by deep white matter ischemia in late adulthood. J Magn Reson Imaging. 2006 Oct; 24(4):747-55. Bradley WG, Bahl G, Alksne JF. PMID: 16958056.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    15. Multimodality treatment of trigeminal neuralgia: impact of radiosurgery and high resolution magnetic resonance imaging. J Clin Neurosci. 2006 Feb; 13(2):239-44. Aryan HE, Nakaji P, Lu DC, Alksne JF. PMID: 16439132.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Focal radiation therapy of brain metastases after complete surgical resection. Med Oncol. 2006; 23(3):317-24. Bahl G, White G, Alksne J, Vemuri L, Spear MA. PMID: 17018888.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Neuropsychological change following gamma knife surgery in patients with left temporal lobe epilepsy: a review of three cases. Epilepsy Behav. 2004 Dec; 5(6):949-57. McDonald CR, Norman MA, Tecoma E, Alksne J, Iragui V. PMID: 15582844.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Is a large hat size hazardous to your health? AJNR Am J Neuroradiol. 2004 Oct; 25(9):1454-5; author reply 1455. McComb JG, Bradley WG, Safar FG, Furtado C, Hurtado C, Ord J, Alksne JF. PMID: 15502119.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Increased intracranial volume: a clue to the etiology of idiopathic normal-pressure hydrocephalus? AJNR Am J Neuroradiol. 2004 Oct; 25(9):1479-84. Bradley WG, Safar FG, Furtado C, Hurtado C, Ord J, Alksne JF. PMID: 15502125.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. Role of proton magnetic resonance spectroscopy in the diagnosis of gliomatosis cerebri: a unique pattern of normal choline but elevated Myo-inositol metabolite levels. J Comput Assist Tomogr. 2004 Jan-Feb; 28(1):103-5. Mohana-Borges AV, Imbesi SG, Dietrich R, Alksne J, Amjadi DK. PMID: 14716242.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Improvement of aggressive and antisocial behavior after resection of temporal lobe tumors. Pediatrics. 2003 Nov; 112(5):e430. Nakaji P, Meltzer HS, Singel SA, Alksne JF. PMID: 14595088.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. Thalamic hypometabolism in a patient undergoing vagal nerve stimulation seen on F-18 FDG PET imaging. Clin Nucl Med. 2003 Sep; 28(9):784-5. Petrucci M, Hoh C, Alksne JF. PMID: 12973011.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Growth factor gene therapy for Alzheimer disease. Neurosurg Focus. 2002 Nov 15; 13(5):e5. Tuszynski MH, U HS, Alksne J, Bakay RA, Pay MM, Merrill D, Thal LJ. PMID: 15769074.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    24. Pilocytic astrocytoma presenting as an extra-axial tumor in the cerebellopontine angle: case report. Neurosurgery. 1995 Jul; 37(1):125-8. Beutler AS, Hsiang JK, Moorhouse DF, Hansen LA, Alksne JF. PMID: 8587672.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    25. Intraoperative assessment of aneurysm clip placement by intravenous fluorescein angiography. Neurosurgery. 1994 Nov; 35(5):970-3; discussion 973. Wrobel CJ, Meltzer H, Lamond R, Alksne JF. PMID: 7838352.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    26. A comparison of the effects on neuronal Golgi morphology, assessed with electron microscopy, of cardiopulmonary bypass, low-flow bypass, and circulatory arrest during profound hypothermia. J Thorac Cardiovasc Surg. 1992 Nov; 104(5):1396-404. Scheller MS, Branson PJ, Cornacchia LG, Alksne JF. PMID: 1434722.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    27. Retromastoid cisternal Ommaya reservoir for intrathecal therapy of coccidioidomycosis meningitis. Technical note. J Neurosurg. 1992 Sep; 77(3):476-7. Wrobel CJ, Alksne JF. PMID: 1506899.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Masking of epileptiform activity by propofol during seizure surgery. Anesthesiology. 1992 Apr; 76(4):652-4. Drummond JC, Iragui-Madoz VJ, Alksne JF, Kalkman CJ. PMID: 1550293.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Diagnosis and treatment of an odontoid fracture in a patient with polyostotic fibrous dysplasia: case report. Neurosurgery. 1989 Jun; 24(6):905-9. Stompro BE, Alksne JF, Press GA. PMID: 2747866.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Modification of experimental post-subarachnoid hemorrhage vasculopathy with intracisternal plasmin. Neurosurgery. 1988 Sep; 23(3):335-7. Alksne JF, Branson PJ, Bailey M. PMID: 2976126.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    31. Demonstration by magnetic resonance of symptomatic spinal epidural lipomatosis. Neurosurgery. 1987 Sep; 21(3):414-5. Healy ME, Hesselink JR, Ostrup RC, Alksne JF. PMID: 3670587.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. Success of microvascular decompression with and without prior surgical therapy for trigeminal neuralgia. J Neurosurg. 1984 Jan; 60(1):104-7. Barba D, Alksne JF. PMID: 6689703.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    33. Needle biopsy under computerized tomographic control: a method for tissue diagnosis in intracranial lesions. Neurosurgery. 1979 Dec; 5(6):671-4. James HE, Wells M, Alksne JF, Wickbom I, Siemers P, Brahme F, Rosenberg J. PMID: 534075.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Electron-microscope study of the effect of increased intracranial pressure on the arachnoid villus. J Neurosurg. 1965 May; 22(5):481-8. Alksne JF, White LE. PMID: 5825610.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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