Najla Kfoury-beaumont

Title(s)	ASST RES-FY-NON REP, Neurological Surgery
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

Washington University In Saint Louis, Saint Louis, MO	Postdoctoral Researcher		Neurodegeneration, Epigenetics & Brain Tumors
Wayne State University, Detroit, MI	Ph.D.	12/2009	Molecular Biology & Genetics/Neuroscience
Wayne State University, Detroit, MI	MS	05/2005	Clinical Laboratory Sciences
American University of Beirut, Beirut, Lebanon	BS	05/2002	Medical Laboratory Sciences

Overview

Najla Kfoury-Beaumont, PhD, is the co-principal investigator of the Brain Tumor Epigenomics Laboratory at UC San Diego. Her research centers on uncovering sex-specific epigenetic differences in brain tumors that impart males with increased risk and resistance to therapy and females with lower cancer incidence and enhanced responsiveness to therapy. Understanding the effects of sex differences on genetic and epigenetic alterations in tumorigenesis is fundamental to developing personalized, sex-specific therapeutic strategies. In addition, she co-chairs the Department of Neurological Surgery’s Grant Review Committee, which supports faculty and resident applications for extramural funding.

Dr. Kfoury-Beaumont is committed to creating a more inclusive future for biomedical research. She actively mentors and trains students who are women and/or members of historically underrepresented communities in science, including through UC San Diego's SURF and STARS programs. She is a member of the Society for Neuro-Oncology Women and Diversity Committee and a member of the Department of Neurological Surgery’s equity, diversity and inclusion (EDI) committee.

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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma. Commun Biol. 2022 08 02; 5(1):781. Broestl L, Warrington NM, Grandison L, Abou-Antoun T, Tung O, Shenoy S, Tallman MM, Rhee G, Yang W, Sponagel J, Yang L, Kfoury-Beaumont N, Hill CM, Qanni SA, Mao DD, Kim AH, Stewart SA, Venere M, Luo J, Rubin JB. PMID: 35918603; PMCID: PMC9345919.

View in: PubMed Mentions: 7 Translation:Humans Animals Cells
The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential. BMC Biol. 2022 05 30; 20(1):124. Kfoury-Beaumont N, Prakasam R, Pondugula S, Lagas JS, Matkovich S, Gontarz P, Yang L, Yano H, Kim AH, Rubin JB, Kroll KL. PMID: 35637482; PMCID: PMC9153095.

View in: PubMed Mentions: 12 Fields:
Bio Biology
Translation:Humans Cells
Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). Kfoury N, Qi Z, Prager BC, Wilkinson MN, Broestl L, Berrett KC, Moudgil A, Sankararaman S, Chen X, Gertz J, Rich JN, Mitra RD, Rubin JB. PMID: 33850013; PMCID: PMC8072233.

View in: PubMed Mentions: 16 Fields:
Sci Science
Translation:Humans Animals Cells
Cooperative p16 and p21 action protects female astrocytes from transformation. Acta Neuropathol Commun. 2018 02 20; 6(1):12. Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JB. PMID: 29458417; PMCID: PMC5819173.

View in: PubMed Mentions: 31 Fields:
Neu Neurology
Translation:Animals Cells
Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiol Dis. 2017 Oct; 106:222-234. Reilly P, Winston CN, Baron KR, Trejo M, Rockenstein EM, Akers JC, Kfoury N, Diamond M, Masliah E, Rissman RA, Yuan SH. PMID: 28610892; PMCID: PMC5593133.

View in: PubMed Mentions: 31 Fields:
Neu Neurology
Translation:Humans Animals Cells
Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma. J Biol Rhythms. 2017 04; 32(2):121-129. Slat EA, Sponagel J, Marpegan L, Simon T, Kfoury N, Kim A, Binz A, Herzog ED, Rubin JB. PMID: 28470120; PMCID: PMC6410359.

View in: PubMed Mentions: 31 Fields:
Phy Physiology
Translation:Humans Animals Cells
Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4. Cancer Res. 2017 03 15; 77(6):1416-1426. Ward SA, Warrington NM, Taylor S, Kfoury N, Luo J, Rubin JB. PMID: 28031228; PMCID: PMC5505622.

View in: PubMed Mentions: 7 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron. 2013 Oct 16; 80(2):402-414. Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM. PMID: 24075978; PMCID: PMC3924573.

View in: PubMed Mentions: 284 Fields:
Neu Neurology
Translation:Humans Animals Cells
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3138-47. Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI. PMID: 23898162; PMCID: PMC3746848.

View in: PubMed Mentions: 417 Fields:
Sci Science
Translation:Humans Animals Cells
Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem. 2012 Jun 01; 287(23):19440-51. Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI. PMID: 22461630; PMCID: PMC3365982.

View in: PubMed Mentions: 292 Fields:
Bio Biochemistry
Translation:Humans Cells
Identification of neuronal target genes for CCAAT/enhancer binding proteins. Mol Cell Neurosci. 2009 Mar; 40(3):313-27. Kfoury N, Kapatos G. PMID: 19103292; PMCID: PMC2703816.

View in: PubMed Mentions: 25 Fields:
Cel Cell Biology Mol Molecular Biology Neu Neurology
Translation:Humans Animals Cells
Quantification and assessment of viability of Cryptococcus neoformans by LightCycler amplification of capsule gene mRNA. J Med Microbiol. 2004 Dec; 53(Pt 12):1201-1206. Amjad M, Kfoury N, Cha R, Mobarak R. PMID: 15585498.

View in: PubMed Mentions: 1 Fields:
Mic Microbiology
Translation:Animals