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Michael Castle

TitlePostdoctoral Scholar
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0626
La Jolla CA 92093
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    1. Castle M, Turunen HT, Vandenberghe LH, Wolfe JH. Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids. Methods Mol Biol. 2016; 1382:133-49. PMID: 26611584; PMCID: PMC4993104.
    2. Castle M, Gershenson ZT, Giles AR, Holzbaur EL, Wolfe JH. Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport. Hum Gene Ther. 2014 Aug; 25(8):705-20. PMID: 24694006; PMCID: PMC4137353.
    3. Castle M, Perlson E, Holzbaur EL, Wolfe JH. Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment. Mol Ther. 2014 Mar; 22(3):554-566. PMID: 24100640; PMCID: PMC3944332.
    4. Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle M, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J. Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med. 2011 Jun 22; 3(88):88ra54. PMID: 21697530.
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