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Michael Castle

Title(s)Assistant Professor In Residence, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell transplantation. Nat Biotechnol. 2025 Nov 17. Sinopoulou E, Rosenzweig ES, Brock JH, Kumamaru H, Salegio EA, Castle MJ, Weber JL, Wurr R, Macon R, Chow MW, Huie JR, Kyritsis N, Havton LA, Nout-Lomas YS, Sparrey CJ, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH. PMID: 41249838; PMCID: PMC12802577.
      View in: PubMed   Mentions:    Fields:    
    2. Thiorphan reprograms neurons to promote functional recovery after spinal cord injury. Nature. 2025 12; 648(8093):402-408. van Niekerk EA, de Freria CM, Mancarci BO, Groeniger K, Kulinich D, Riley T, Kawaguchi R, Okawa S, Vokes T, Rosenzweig ES, Sinopoulou E, Castle MJ, Huie R, Ferguson AR, Kfoury-Beaumont N, Khalessi A, Pavlidis P, Tuszynski MH. PMID: 41162703; PMCID: PMC12695623.
      View in: PubMed   Mentions:
    3. AAV2retro Enters Axons of Passage and Extensively Transduces Corticospinal Neurons After Injection into Spinal White Matter. Brain Sci. 2025 Sep 28; 15(10). Nakashima KT, Wang S, Castle MJ. PMID: 41154154; PMCID: PMC12564753.
      View in: PubMed   Mentions:
    4. Intersectional targeting of defined neural circuits by adeno-associated virus vectors. J Neurosci Res. 2021 04; 99(4):981-990. Weinholtz CA, Castle MJ. PMID: 33341969; PMCID: PMC8786212.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    5. Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery. Hum Gene Ther. 2020 04; 31(7-8):415-422. Castle MJ, Baltanás FC, Kovacs I, Nagahara AH, Barba D, Tuszynski MH. PMID: 32126838; PMCID: PMC7194314.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCellsCTClinical Trials
    6. In Situ Hybridization for Detection of AAV-Mediated Gene Expression. Methods Mol Biol. 2019; 1950:107-122. Hunter JE, Gurda BL, Yoon SY, Castle MJ, Wolfe JH. PMID: 30783970; PMCID: PMC7029785.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion. Sci Adv. 2018 11; 4(11):eaau9859. Castle MJ, Cheng Y, Asokan A, Tuszynski MH. PMID: 30443600; PMCID: PMC6235539.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    8. Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids. Methods Mol Biol. 2016; 1382:133-49. Castle MJ, Turunen HT, Vandenberghe LH, Wolfe JH. PMID: 26611584; PMCID: PMC4993104.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    9. Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport. Hum Gene Ther. 2014 Aug; 25(8):705-20. Castle MJ, Gershenson ZT, Giles AR, Holzbaur EL, Wolfe JH. PMID: 24694006; PMCID: PMC4137353.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    10. Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment. Mol Ther. 2014 Mar; 22(3):554-566. Castle MJ, Perlson E, Holzbaur EL, Wolfe JH. PMID: 24100640; PMCID: PMC3944332.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    11. Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med. 2011 Jun 22; 3(88):88ra54. Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle MJ, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J. PMID: 21697530; PMCID: PMC5027886.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
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