Loading...

Miguel Alejandro Lopez-Ramirez

Title(s)Assistant Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0726
La Jolla CA 92093
Phone000-000-NULL
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    In the past years, our research has been focused on studying the molecular, genetic and cellular mechanism that regulates the vasculature in health and disease. Our research is using mouse and zebrafish genetics, cell biology and bioinformatics tools to increase our understanding of the biological components of cerebral cavernous malformations (CCM) and neuroinflammation. The ultimate goal of our research is to provide non-invasive, safe, and effective therapies to cardiovascular and neurological diseases.

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation. Blood. 2020 Jun 09. Lagarrigue F, Paul DS, Gingras AR, Valadez AJ, Sun H, Lin J, Cuevas MN, Ablack JNG, Lopez Ramirez MA, Bergmeier W, Ginsberg MH. PMID: 32518959.
      View in: PubMed   Mentions: 1     Fields:    
    2. Isolation and Purification of Mouse Brain Endothelial Cells to Study Cerebral Cavernous Malformation Disease. Methods Mol Biol. 2020; 2152:139-150. Hale P, Soliman SI, Sun H, Lopez-Ramirez MA. PMID: 32524550.
      View in: PubMed   Mentions:    Fields:    
    3. ß7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells. Cell Mol Gastroenterol Hepatol. 2020; 9(3):369-385. Sun H, Kuk W, Rivera-Nieves J, Lopez-Ramirez MA, Eckmann L, Ginsberg MH. PMID: 31707128.
      View in: PubMed   Mentions: 2     Fields:    
    4. Cerebral Cavernous Malformations (CCM): Methods and Protocols. Isolation and purification of mouse brain endothelial cells to study Cerebral Cavernous Malformation disease. 2019. Preston Hale, Shady Ibrahim Soliman, Hao Sun, Miguel Alejandro Lopez-Ramirez.
    5. Frontline Science: A flexible kink in the transmembrane domain impairs ß2 integrin extension and cell arrest from rolling. J Leukoc Biol. 2020 02; 107(2):175-183. Sun H, Fan Z, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. PMID: 31475386.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. bioRxiv. Pharmacological inhibition of the heart of glass (HEG1)-Krev interaction trapped protein 1 (KRIT1) protein complex increases Krüppel-like Factors 4 and 2 (KLF4/2) expression in endothelial cells. 2019. Miguel Alejandro Lopez-Ramirez, Mark K. Haynes, Preston Hale, Killian Oukoloff, Matthew Bautista, Brendan Gongol, John Y. Shyy, Carlo Ballatore, Larry A. Sklar, Alexandre R. Gingras.
    7. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 08 19; 7(1):132. Koskimäki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrión-Penagos J, Lyne SB, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IA. PMID: 31426861.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Biomarkers of cavernous angioma with symptomatic hemorrhage. JCI Insight. 2019 06 20; 4(12). Lyne SB, Girard R, Koskimäki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrión-Penagos J, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IA. PMID: 31217347.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. J Cell Biol. 2019 06 03; 218(6):1799-1809. Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH. PMID: 30988001.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. JCI Insight. 2019 Feb 07; 4(3). Koskimäki J, Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Lyne S, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Carrión-Penagos J, Romanos S, Fonseca G, Lopez-Ramirez MA, Chapman EM, Popiel E, Tang AT, Akers A, Faber P, Andrade J, Ginsberg M, Derry WB, Kahn ML, Marchuk DA, Awad IA. PMID: 30728328.
      View in: PubMed   Mentions: 5     Fields:    
    11. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood. 2019 01 17; 133(3):193-204. Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. PMID: 30442679.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018 09 25; 2(18):2358-2368. Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. PMID: 30242097.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330. Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA. PMID: 29946133.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346. Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH. PMID: 28970240.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. In press. MicroRNAs in brain endothelium and inflammation. 2017. D. Roig-Carles*, C. Cerutti*, M. A. Lopez-Ramirez*, D. Wu, David K. Male, H.E. de Vries and I.A. Romero.
    16. MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro. Fluids Barriers CNS. 2016 May 31; 13(1):8. Cerutti C, Soblechero-Martin P, Wu D, Lopez-Ramirez MA, de Vries H, Sharrack B, Male DK, Romero IA. PMID: 27246706.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    17. Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation. FASEB J. 2016 08; 30(8):2662-72. Lopez-Ramirez MA, Reijerkerk A, de Vries HE, Romero IA. PMID: 27118674.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    18. Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres. J Vis Exp. 2016 Feb 29; (108):53617. Lopez-Ramirez MA, Calvo CF, Ristori E, Thomas JL, Nicoli S. PMID: 26967835.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis. Dev Cell. 2015 Mar 09; 32(5):546-60. Ristori E, Lopez-Ramirez MA, Narayanan A, Hill-Teran G, Moro A, Calvo CF, Thomas JL, Nicoli S. PMID: 25662174.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-?B activation. J Cereb Blood Flow Metab. 2015 Mar; 35(3):412-23. Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. PMID: 25515214.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    21. MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J. 2014 Jun; 28(6):2551-65. Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE, Hirst MC, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. PMID: 24604078.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    22. Role of miRNAs and epigenetics in neural stem cell fate determination. Epigenetics. 2014 Jan; 9(1):90-100. Lopez-Ramirez MA, Nicoli S. PMID: 24342893.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    23. Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3. Fluids Barriers CNS. 2013 Sep 19; 10(1):27. Lopez-Ramirez MA, Male DK, Wang C, Sharrack B, Wu D, Romero IA. PMID: 24050303.
      View in: PubMed   Mentions: 15     Fields:    
    24. MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. J Neurosci. 2013 Apr 17; 33(16):6857-63. Reijerkerk A, Lopez-Ramirez MA, van Het Hof B, Drexhage JA, Kamphuis WW, Kooij G, Vos JB, van der Pouw Kraan TC, van Zonneveld AJ, Horrevoets AJ, Prat A, Romero IA, de Vries HE. PMID: 23595744.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    25. Investigating the role of inflammation modulated microRNAs and signalling pathways in blood-brain barrier dysfunction. 2012. Miguel Alejandro Lopez-Ramirez.View Publication.
    26. Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. J Immunol. 2012 Sep 15; 189(6):3130-9. Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, Davies HA, Logan K, Pfizenmaier K, Male DK, Sharrack B, Romero IA. PMID: 22896632.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    27. Hepatitis C virus infects the endothelial cells of the blood-brain barrier. Gastroenterology. 2012 Mar; 142(3):634-643.e6. Fletcher NF, Wilson GK, Murray J, Hu K, Lewis A, Reynolds GM, Stamataki Z, Meredith LW, Rowe IA, Luo G, Lopez-Ramirez MA, Baumert TF, Weksler B, Couraud PO, Kim KS, Romero IA, Jopling C, Morgello S, Balfe P, McKeating JA. PMID: 22138189.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    28. Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. Brain Res. 2009 Oct 06; 1292:14-24. Tai LM, Reddy PS, Lopez-Ramirez MA, Davies HA, Male DK, Male AD, Loughlin AJ, Romero IA. PMID: 19631619.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    29. Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling. Int J Dev Neurosci. 2008 Aug; 26(5):497-503. López-Ramírez MA, Domínguez-Monzón G, Vergara P, Segovia J. PMID: 18394855.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    Miguel's Networks
    Concepts (180)
    Derived automatically from this person's publications.
    _
    Co-Authors (6)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _