Miguel Alejandro Lopez-Ramirez
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Title(s) | Assistant Professor, Medicine |
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School | Health Sciences |
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Address | 9500 Gilman Drive #0726 La Jolla CA 92093
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vCard | Download vCard |
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Overview In the past years, our research has been focused on studying the molecular, genetic and cellular mechanism that regulates the vasculature in health and disease. Our research is using mouse and zebrafish genetics, cell biology and bioinformatics tools to increase our understanding of the biological components of cerebral cavernous malformations (CCM) and neuroinflammation. The ultimate goal of our research is to provide non-invasive, safe, and effective therapies to cardiovascular and neurological diseases.
ORNG Applications Bibliographic
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Talin-1 is the principal platelet Rap1 effector of integrin activation. Blood. 2020 Sep 03; 136(10):1180-1190.
Lagarrigue F, Paul DS, Gingras AR, Valadez AJ, Sun H, Lin J, Cuevas MN, Ablack JN, Lopez-Ramirez MA, Bergmeier W, Ginsberg MH. PMID: 32518959.
View in: PubMed Mentions: 1 Fields:
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Isolation and Purification of Mouse Brain Endothelial Cells to Study Cerebral Cavernous Malformation Disease. Methods Mol Biol. 2020; 2152:139-150.
Hale P, Soliman SI, Sun H, Lopez-Ramirez MA. PMID: 32524550.
View in: PubMed Mentions: Fields:
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ß7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells. Cell Mol Gastroenterol Hepatol. 2020; 9(3):369-385.
Sun H, Kuk W, Rivera-Nieves J, Lopez-Ramirez MA, Eckmann L, Ginsberg MH. PMID: 31707128.
View in: PubMed Mentions: 4 Fields:
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Cerebral Cavernous Malformations (CCM): Methods and Protocols. Isolation and purification of mouse brain endothelial cells to study Cerebral Cavernous Malformation disease. 2019.
Preston Hale, Shady Ibrahim Soliman, Hao Sun, Miguel Alejandro Lopez-Ramirez.
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Frontline Science: A flexible kink in the transmembrane domain impairs ß2 integrin extension and cell arrest from rolling. J Leukoc Biol. 2020 02; 107(2):175-183.
Sun H, Fan Z, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. PMID: 31475386.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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bioRxiv. Pharmacological inhibition of the heart of glass (HEG1)-Krev interaction trapped protein 1 (KRIT1) protein complex increases Krüppel-like Factors 4 and 2 (KLF4/2) expression in endothelial cells. 2019.
Miguel Alejandro Lopez-Ramirez, Mark K. Haynes, Preston Hale, Killian Oukoloff, Matthew Bautista, Brendan Gongol, John Y. Shyy, Carlo Ballatore, Larry A. Sklar, Alexandre R. Gingras.
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Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 08 19; 7(1):132.
Koskimäki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrión-Penagos J, Lyne SB, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IA. PMID: 31426861.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Biomarkers of cavernous angioma with symptomatic hemorrhage. JCI Insight. 2019 06 20; 4(12).
Lyne SB, Girard R, Koskimäki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrión-Penagos J, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IA. PMID: 31217347.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. J Cell Biol. 2019 06 03; 218(6):1799-1809.
Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH. PMID: 30988001.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. JCI Insight. 2019 Feb 07; 4(3).
Koskimäki J, Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Lyne S, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Carrión-Penagos J, Romanos S, Fonseca G, Lopez-Ramirez MA, Chapman EM, Popiel E, Tang AT, Akers A, Faber P, Andrade J, Ginsberg M, Derry WB, Kahn ML, Marchuk DA, Awad IA. PMID: 30728328.
View in: PubMed Mentions: 6 Fields:
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Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood. 2019 01 17; 133(3):193-204.
Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. PMID: 30442679.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018 09 25; 2(18):2358-2368.
Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. PMID: 30242097.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330.
Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA. PMID: 29946133.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346.
PMID: 28970240.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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In press. MicroRNAs in brain endothelium and inflammation. 2017.
D. Roig-Carles*, C. Cerutti*, M. A. Lopez-Ramirez*, D. Wu, David K. Male, H.E. de Vries and I.A. Romero.
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MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro. Fluids Barriers CNS. 2016 May 31; 13(1):8.
PMID: 27246706.
View in: PubMed Mentions: 10 Fields: Translation: HumansCells
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Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation. FASEB J. 2016 08; 30(8):2662-72.
PMID: 27118674.
View in: PubMed Mentions: 16 Fields: Translation: Humans
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Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres. J Vis Exp. 2016 Feb 29; (108):53617.
PMID: 26967835.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis. Dev Cell. 2015 Mar 09; 32(5):546-60.
PMID: 25662174.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J Cereb Blood Flow Metab. 2015 Mar; 35(3):412-23.
Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. PMID: 25515214.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimalsCells
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MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J. 2014 Jun; 28(6):2551-65.
PMID: 24604078.
View in: PubMed Mentions: 72 Fields: Translation: HumansAnimalsCells
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Role of miRNAs and epigenetics in neural stem cell fate determination. Epigenetics. 2014 Jan; 9(1):90-100.
PMID: 24342893.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
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Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3. Fluids Barriers CNS. 2013 Sep 19; 10(1):27.
PMID: 24050303.
View in: PubMed Mentions: 14 Fields:
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MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. J Neurosci. 2013 Apr 17; 33(16):6857-63.
PMID: 23595744.
View in: PubMed Mentions: 45 Fields: Translation: HumansCells
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Investigating the role of inflammation modulated microRNAs and signalling pathways in blood-brain barrier dysfunction. 2012.
Miguel Alejandro Lopez-Ramirez. View Publication.
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Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. J Immunol. 2012 Sep 15; 189(6):3130-9.
PMID: 22896632.
View in: PubMed Mentions: 36 Fields: Translation: HumansCells
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Hepatitis C virus infects the endothelial cells of the blood-brain barrier. Gastroenterology. 2012 Mar; 142(3):634-643.e6.
PMID: 22138189.
View in: PubMed Mentions: 63 Fields: Translation: HumansCells
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Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. Brain Res. 2009 Oct 06; 1292:14-24.
Tai LM, Reddy PS, Lopez-Ramirez MA, Davies HA, Male DK, Male AD, Loughlin AJ, Romero IA. PMID: 19631619.
View in: PubMed Mentions: 23 Fields: Translation: HumansCells
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Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling. Int J Dev Neurosci. 2008 Aug; 26(5):497-503.
López-Ramírez MA, Domínguez-Monzón G, Vergara P, Segovia J. PMID: 18394855.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Year | Publications |
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2008 | 1 | 2009 | 1 | 2011 | 1 | 2012 | 2 | 2013 | 3 | 2014 | 2 | 2015 | 1 | 2016 | 3 | 2017 | 2 | 2018 | 3 | 2019 | 8 | 2020 | 2 |
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Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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