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Miguel Alejandro Lopez-Ramirez

Title(s)Assistant Professor, Medicine
SchoolHealth Sciences
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    In the past years, our research has been focused on studying the molecular, genetic and cellular mechanism that regulates the vasculature in health and disease. Our research is using mouse and zebrafish genetics, cell biology and bioinformatics tools to increase our understanding of the biological components of cerebral cavernous malformations (CCM) and neuroinflammation. The ultimate goal of our research is to provide non-invasive, safe, and effective therapies to cardiovascular and neurological diseases.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Preston Hale, Shady Ibrahim Soliman, Hao Sun, Miguel Alejandro Lopez-Ramirez.Cerebral Cavernous Malformations (CCM): Methods and Protocols. Isolation and purification of mouse brain endothelial cells to study Cerebral Cavernous Malformation disease. 2019.
    2. Miguel Alejandro Lopez-Ramirez, Mark K. Haynes, Preston Hale, Killian Oukoloff, Matthew Bautista, Brendan Gongol, John Y. Shyy, Carlo Ballatore, Larry A. Sklar, Alexandre R. Gingras.bioRxiv. Pharmacological inhibition of the heart of glass (HEG1)-Krev interaction trapped protein 1 (KRIT1) protein complex increases Krüppel-like Factors 4 and 2 (KLF4/2) expression in endothelial cells. 2019.
    3. Koskimäki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrión-Penagos J, Lyne SB, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IA. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 Aug 19; 7(1):132. PMID: 31426861.
      View in: PubMed
    4. Lyne SB, Girard R, Koskimäki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrión-Penagos J, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IA. Biomarkers of cavernous angioma with symptomatic hemorrhage. JCI Insight. 2019 Jun 20; 4(12). PMID: 31217347.
      View in: PubMed
    5. Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH. Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. J Cell Biol. 2019 Jun 03; 218(6):1799-1809. PMID: 30988001.
      View in: PubMed
    6. Koskimäki J, Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Lyne S, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Carrión-Penagos J, Romanos S, Fonseca G, Lopez-Ramirez MA, Chapman EM, Popiel E, Tang AT, Akers A, Faber P, Andrade J, Ginsberg M, Derry WB, Kahn ML, Marchuk DA, Awad IA. Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728328.
      View in: PubMed
    7. Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood. 2019 Jan 17; 133(3):193-204. PMID: 30442679.
      View in: PubMed
    8. Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018 Sep 25; 2(18):2358-2368. PMID: 30242097.
      View in: PubMed
    9. Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA. Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330. PMID: 29946133.
      View in: PubMed
    10. Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346. PMID: 28970240.
      View in: PubMed
    11. D. Roig-Carles*, C. Cerutti*, M. A. Lopez-Ramirez*, D. Wu, David K. Male, H.E. de Vries and I.A. Romero.In press. MicroRNAs in brain endothelium and inflammation. 2017.
    12. Cerutti C, Soblechero-Martin P, Wu D, Lopez-Ramirez MA, de Vries H, Sharrack B, Male DK, Romero IA. MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro. Fluids Barriers CNS. 2016 May 31; 13(1):8. PMID: 27246706.
      View in: PubMed
    13. Lopez-Ramirez MA, Reijerkerk A, de Vries HE, Romero IA. Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation. FASEB J. 2016 08; 30(8):2662-72. PMID: 27118674.
      View in: PubMed
    14. Lopez-Ramirez MA, Calvo CF, Ristori E, Thomas JL, Nicoli S. Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres. J Vis Exp. 2016 Feb 29; (108):53617. PMID: 26967835.
      View in: PubMed
    15. Ristori E, Lopez-Ramirez MA, Narayanan A, Hill-Teran G, Moro A, Calvo CF, Thomas JL, Nicoli S. A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis. Dev Cell. 2015 Mar 09; 32(5):546-60. PMID: 25662174.
      View in: PubMed
    16. Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-?B activation. J Cereb Blood Flow Metab. 2015 Mar; 35(3):412-23. PMID: 25515214.
      View in: PubMed
    17. Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE, Hirst MC, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J. 2014 Jun; 28(6):2551-65. PMID: 24604078.
      View in: PubMed
    18. Lopez-Ramirez MA, Nicoli S. Role of miRNAs and epigenetics in neural stem cell fate determination. Epigenetics. 2014 Jan; 9(1):90-100. PMID: 24342893.
      View in: PubMed
    19. Lopez-Ramirez MA, Male DK, Wang C, Sharrack B, Wu D, Romero IA. Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3. Fluids Barriers CNS. 2013 Sep 19; 10(1):27. PMID: 24050303.
      View in: PubMed
    20. Reijerkerk A, Lopez-Ramirez MA, van Het Hof B, Drexhage JA, Kamphuis WW, Kooij G, Vos JB, van der Pouw Kraan TC, van Zonneveld AJ, Horrevoets AJ, Prat A, Romero IA, de Vries HE. MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. J Neurosci. 2013 Apr 17; 33(16):6857-63. PMID: 23595744.
      View in: PubMed
    21. Miguel Alejandro Lopez-Ramirez.Investigating the role of inflammation modulated microRNAs and signalling pathways in blood-brain barrier dysfunction. 2012.
    22. Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, Davies HA, Logan K, Pfizenmaier K, Male DK, Sharrack B, Romero IA. Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. J Immunol. 2012 Sep 15; 189(6):3130-9. PMID: 22896632.
      View in: PubMed
    23. Fletcher NF, Wilson GK, Murray J, Hu K, Lewis A, Reynolds GM, Stamataki Z, Meredith LW, Rowe IA, Luo G, Lopez-Ramirez MA, Baumert TF, Weksler B, Couraud PO, Kim KS, Romero IA, Jopling C, Morgello S, Balfe P, McKeating JA. Hepatitis C virus infects the endothelial cells of the blood-brain barrier. Gastroenterology. 2012 Mar; 142(3):634-643.e6. PMID: 22138189.
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    24. Tai LM, Reddy PS, Lopez-Ramirez MA, Davies HA, Male DK, Male AD, Loughlin AJ, Romero IA. Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. Brain Res. 2009 Oct 06; 1292:14-24. PMID: 19631619.
      View in: PubMed
    25. López-Ramírez MA, Domínguez-Monzón G, Vergara P, Segovia J. Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling. Int J Dev Neurosci. 2008 Aug; 26(5):497-503. PMID: 18394855.
      View in: PubMed