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    Miguel Alejandro Lopez-Ramirez

    Address9500 Gilman Drive #0726
    CA La Jolla 92093
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      In the past years, our research has been focused on studying the molecular, genetic and cellular mechanism that regulates the vasculature in health and disease. Our research is using mouse and zebrafish genetics, cell biology and bioinformatics tools to increase our understanding of the biological components of cerebral cavernous malformations (CCM) and neuroinflammation. The ultimate goal of our research is to provide non-invasive, safe, and effective therapies to cardiovascular and neurological diseases.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Miguel Alejandro Lopez-Ramirez, Gregory Fonseca, Hussein A. Zeineddine, Romuald Girard, Thomas Moore, Angela Pham et al. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. Journal of Experimental Medicine. 2017; (In press).
      2. D. Roig-Carles*, C. Cerutti*, M. A. Lopez-Ramirez*, D. Wu, David K. Male, H.E. de Vries and I.A. Romero. In press. MicroRNAs in brain endothelium and inflammation. 2017.
      3. Cerutti C, Soblechero-Martin P, Wu D, Lopez-Ramirez MA, de Vries H, Sharrack B, Male DK, Romero IA. MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro. Fluids Barriers CNS. 2016; 13(1):8. PMID: 27246706.
        View in: PubMed
      4. Lopez-Ramirez MA, Reijerkerk A, de Vries HE, Romero IA. Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation. FASEB J. 2016 Apr 26. PMID: 27118674.
        View in: PubMed
      5. Lopez-Ramirez MA, Calvo CF, Ristori E, Thomas JL, Nicoli S. Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres. J Vis Exp. 2016; (108). PMID: 26967835.
        View in: PubMed
      6. Ristori E, Lopez-Ramirez MA, Narayanan A, Hill-Teran G, Moro A, Calvo CF, Thomas JL, Nicoli S. A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis. Dev Cell. 2015 Mar 9; 32(5):546-60. PMID: 25662174.
        View in: PubMed
      7. Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-?B activation. J Cereb Blood Flow Metab. 2015 Mar; 35(3):412-23. PMID: 25515214.
        View in: PubMed
      8. Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE, Hirst MC, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J. 2014 Jun; 28(6):2551-65. PMID: 24604078.
        View in: PubMed
      9. Lopez-Ramirez MA, Nicoli S. Role of miRNAs and epigenetics in neural stem cell fate determination. Epigenetics. 2014 Jan; 9(1):90-100. PMID: 24342893.
        View in: PubMed
      10. Lopez-Ramirez MA, Male DK, Wang C, Sharrack B, Wu D, Romero IA. Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3. Fluids Barriers CNS. 2013; 10(1):27. PMID: 24050303.
        View in: PubMed
      11. Reijerkerk A, Lopez-Ramirez MA, van Het Hof B, Drexhage JA, Kamphuis WW, Kooij G, Vos JB, van der Pouw Kraan TC, van Zonneveld AJ, Horrevoets AJ, Prat A, Romero IA, de Vries HE. MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. J Neurosci. 2013 Apr 17; 33(16):6857-63. PMID: 23595744.
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      12. Miguel Alejandro Lopez-Ramirez. Investigating the role of inflammation modulated microRNAs and signalling pathways in blood-brain barrier dysfunction. 2012.
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      13. Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, Davies HA, Logan K, Pfizenmaier K, Male DK, Sharrack B, Romero IA. Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. J Immunol. 2012 Sep 15; 189(6):3130-9. PMID: 22896632.
        View in: PubMed
      14. Fletcher NF, Wilson GK, Murray J, Hu K, Lewis A, Reynolds GM, Stamataki Z, Meredith LW, Rowe IA, Luo G, Lopez-Ramirez MA, Baumert TF, Weksler B, Couraud PO, Kim KS, Romero IA, Jopling C, Morgello S, Balfe P, McKeating JA. Hepatitis C virus infects the endothelial cells of the blood-brain barrier. Gastroenterology. 2012 Mar; 142(3):634-643.e6. PMID: 22138189.
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      15. Tai LM, Reddy PS, Lopez-Ramirez MA, Davies HA, Male DK, Male AD, Loughlin AJ, Romero IA. Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. Brain Res. 2009 Oct 6; 1292:14-24. PMID: 19631619.
        View in: PubMed
      16. López-Ramírez MA, Domínguez-Monzón G, Vergara P, Segovia J. Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling. Int J Dev Neurosci. 2008 Aug; 26(5):497-503. PMID: 18394855.
        View in: PubMed
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