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Richard Firtel

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0380
La Jolla CA 92093
Phone858-534-2788
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    Collapse Research 
    Collapse Research Activities and Funding
    Bio-Mechanics of Directional Migration of Leukocytes
    NIH/NIGMS R01GM084227Sep 30, 2010 - Jun 30, 2019
    Role: Principal Investigator
    CHEMOTAXIS IN DICTYOSTELIUM DISCOIDEUM: AN INTEGRATIVE APPROACH
    NIH P01GM078586Jul 1, 2006 - Jul 31, 2017
    Role: Co-Investigator
    Role of Rac and Rac Effectors in Controlling Chemotaxis
    NIH/NIGMS R01GM062847Jan 1, 2002 - Dec 31, 2006
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    Signalling Processes in Dictyostelium
    NIH/NIGMS R01GM037830Jul 1, 1986 - Jan 31, 2016
    Role: Principal Investigator
    ANALYSIS OF DEVELOPMENTALLY REGULATED GENES
    NIH/NIGMS R01GM030693Apr 1, 1982 - Mar 31, 1992
    Role: Principal Investigator
    Gene Structure and Transciptional Regulation
    NIH/NIGMS R01GM024279Sep 1, 1977 - Feb 28, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baumgardner K, Lin C, Firtel R, Lacal J. Phosphodiesterase PdeD, dynacortin, and a Kelch repeat-containing protein are direct GSK3 substrates in Dictyostelium that contribute to chemotaxis towards cAMP. Environ Microbiol. 2018 May; 20(5):1888-1903. PMID: 29626371.
      View in: PubMed
    2. Lacal Romero J, Shen Z, Baumgardner K, Wei J, Briggs SP, Firtel R. The Dictyostelium GSK3 kinase GlkA coordinates signal relay and chemotaxis in response to growth conditions. Dev Biol. 2018 03 01; 435(1):56-72. PMID: 29355521.
      View in: PubMed
    3. Álvarez-González B, Zhang S, Gómez-González M, Meili R, Firtel R, Lasheras JC, Del Álamo JC. Two-Layer Elastographic 3-D Traction Force Microscopy. Sci Rep. 2017 Jan 11; 7:39315. PMID: 28074837.
      View in: PubMed
    4. Liu Y, Lacal J, Firtel R, Kortholt A. Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization. Small GTPases. 2016 Oct 07; 1-5. PMID: 27715492.
      View in: PubMed
    5. Liu Y, Lacal J, Veltman DM, Fusetti F, van Haastert PJ, Firtel R, Kortholt A. A Ga-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis. Dev Cell. 2016 Jun 06; 37(5):458-72. PMID: 27237792.
      View in: PubMed
    6. Bastounis E, Álvarez-González B, del Álamo JC, Lasheras JC, Firtel R. Cooperative cell motility during tandem locomotion of amoeboid cells. Mol Biol Cell. 2016 Apr 15; 27(8):1262-71. PMID: 26912787; PMCID: PMC4831880.
    7. Álvarez-González B, Meili R, Bastounis E, Firtel R, Lasheras JC, Del Álamo JC. Three-dimensional balance of cortical tension and axial contractility enables fast amoeboid migration. Biophys J. 2015 Feb 17; 108(4):821-832. PMID: 25692587.
      View in: PubMed
    8. Alvarez-González B, Meili R, Firtel R, Bastounis E, Del Álamo JC, Lasheras JC. Cytoskeletal Mechanics Regulating Amoeboid Cell Locomotion. Appl Mech Rev. 2014 Jun 05; 66(5). PMID: 25328163.
      View in: PubMed
    9. Bastounis E, Meili R, Álvarez-González B, Francois J, del Álamo JC, Firtel R, Lasheras JC. Both contractile axial and lateral traction force dynamics drive amoeboid cell motility. J Cell Biol. 2014 Mar 17; 204(6):1045-61. PMID: 24637328; PMCID: PMC3998796.
    10. Sumita K, Yoshino H, Sasaki M, Majd N, Kahoud ER, Takahashi H, Takeuchi K, Kuroda T, Lee S, Charest PG, Takeda K, Asara JM, Firtel R, Anastasiou D, Sasaki AT. Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis. J Biol Chem. 2014 Feb 14; 289(7):3950-9. PMID: 24338482; PMCID: PMC3924263.
    11. del Álamo JC, Meili R, Álvarez-González B, Alonso-Latorre B, Bastounis E, Firtel R, Lasheras JC. Three-dimensional quantification of cellular traction forces and mechanosensing of thin substrata by fourier traction force microscopy. PLoS One. 2013; 8(9):e69850. PMID: 24023712; PMCID: PMC3762859.
    12. Kölsch V, Shen Z, Lee S, Plak K, Lotfi P, Chang J, Charest PG, Romero JL, Jeon TJ, Kortholt A, Briggs SP, Firtel R. Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Mol Biol Cell. 2013 Jan; 24(2):100-14. PMID: 23135995; PMCID: PMC3541958.
    13. Rappel WJ, Firtel R. Adaptation in a eukaryotic pathway: combining experiments with modeling. Cell Cycle. 2012 Mar 15; 11(6):1051-2. PMID: 22391206; PMCID: PMC3335914.
    14. Kee YS, Ren Y, Dorfman D, Iijima M, Firtel R, Iglesias PA, Robinson DN. A mechanosensory system governs myosin II accumulation in dividing cells. Mol Biol Cell. 2012 Apr; 23(8):1510-23. PMID: 22379107; PMCID: PMC3327329.
    15. Takeda K, Shao D, Adler M, Charest PG, Loomis WF, Levine H, Groisman A, Rappel WJ, Firtel R. Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal. 2012 Jan 03; 5(205):ra2. PMID: 22215733; PMCID: PMC3928814.
    16. Bastounis E, Meili R, Alonso-Latorre B, del Álamo JC, Lasheras JC, Firtel R. The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility. Mol Biol Cell. 2011 Nov; 22(21):3995-4003. PMID: 21900496; PMCID: PMC3204062.
    17. Hecht I, Skoge ML, Charest PG, Ben-Jacob E, Firtel R, Loomis WF, Levine H, Rappel WJ. Activated membrane patches guide chemotactic cell motility. PLoS Comput Biol. 2011 Jun; 7(6):e1002044. PMID: 21738453; PMCID: PMC3127810.
    18. Alonso-Latorre B, Del Álamo JC, Meili R, Firtel R, Lasheras JC. An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells. Cell Mol Bioeng. 2011 Dec; 4(4):603-615. PMID: 22207880.
      View in: PubMed
    19. Kicka S, Shen Z, Annesley SJ, Fisher PR, Lee S, Briggs S, Firtel R. The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton. Mol Biol Cell. 2011 Jul 01; 22(13):2198-211. PMID: 21551065; PMCID: PMC3128523.
    20. Charest PG, Firtel R. "TORCing" neutrophil chemotaxis. Dev Cell. 2010 Dec 14; 19(6):795-6. PMID: 21145496; PMCID: PMC3033560.
    21. Charest PG, Shen Z, Lakoduk A, Sasaki AT, Briggs SP, Firtel R. A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev Cell. 2010 May 18; 18(5):737-49. PMID: 20493808; PMCID: PMC2893887.
    22. Lee S, Shen Z, Robinson DN, Briggs S, Firtel R. Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis. Mol Biol Cell. 2010 Jun 01; 21(11):1810-24. PMID: 20375144; PMCID: PMC2877640.
    23. Meili R, Alonso-Latorre B, del Alamo JC, Firtel R, Lasheras JC. Myosin II is essential for the spatiotemporal organization of traction forces during cell motility. Mol Biol Cell. 2010 Feb 01; 21(3):405-17. PMID: 19955212; PMCID: PMC2814786.
    24. Ren Y, Effler JC, Norstrom M, Luo T, Firtel R, Iglesias PA, Rock RS, Robinson DN. Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I. Curr Biol. 2009 Sep 15; 19(17):1421-8. PMID: 19646871; PMCID: PMC2763054.
    25. Jeon TJ, Lee S, Weeks G, Firtel R. Regulation of Dictyostelium morphogenesis by RapGAP3. Dev Biol. 2009 Apr 15; 328(2):210-20. PMID: 19284976.
      View in: PubMed
    26. Sasaki AT, Firtel R. Spatiotemporal regulation of Ras-GTPases during chemotaxis. Methods Mol Biol. 2009; 571:333-48. PMID: 19763978.
      View in: PubMed
    27. Para A, Krischke M, Merlot S, Shen Z, Oberholzer M, Lee S, Briggs S, Firtel R. Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility. Mol Biol Cell. 2009 Jan; 20(2):699-707. PMID: 19037099; PMCID: PMC2626555.
    28. Zhang S, Charest PG, Firtel R. Spatiotemporal regulation of Ras activity provides directional sensing. Curr Biol. 2008 Oct 28; 18(20):1587-1593. PMID: 18948008; PMCID: PMC2590931.
    29. Du F, Edwards K, Shen Z, Sun B, De Lozanne A, Briggs S, Firtel R. Regulation of contractile vacuole formation and activity in Dictyostelium. EMBO J. 2008 Aug 06; 27(15):2064-76. PMID: 18636095; PMCID: PMC2516880.
    30. Janetopoulos C, Firtel R. Directional sensing during chemotaxis. FEBS Lett. 2008 Jun 18; 582(14):2075-85. PMID: 18452713; PMCID: PMC2519798.
    31. Kölsch V, Charest PG, Firtel R. The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci. 2008 Mar 01; 121(Pt 5):551-9. PMID: 18287584; PMCID: PMC2671295.
    32. Araki T, Langenick J, Gamper M, Firtel R, Williams JG. Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase. Development. 2008 Apr; 135(7):1347-53. PMID: 18305004; PMCID: PMC2671291.
    33. Jeon TJ, Lee DJ, Lee S, Weeks G, Firtel R. Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells. J Cell Biol. 2007 Dec 03; 179(5):833-43. PMID: 18039932; PMCID: PMC2099181.
    34. Del Alamo JC, Meili R, Alonso-Latorre B, Rodríguez-Rodríguez J, Aliseda A, Firtel R, Lasheras JC. Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13343-8. PMID: 17684097; PMCID: PMC1940228.
    35. Sasaki AT, Janetopoulos C, Lee S, Charest PG, Takeda K, Sundheimer LW, Meili R, Devreotes PN, Firtel R. G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol. 2007 Jul 16; 178(2):185-91. PMID: 17635933; PMCID: PMC2064438.
    36. Jeon TJ, Lee DJ, Merlot S, Weeks G, Firtel R. Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J Cell Biol. 2007 Mar 26; 176(7):1021-33. PMID: 17371831; PMCID: PMC2064086.
    37. Mendoza MC, Booth EO, Shaulsky G, Firtel R. MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis. Mol Cell Biol. 2007 May; 27(10):3817-27. PMID: 17353263; PMCID: PMC1899987.
    38. Takeda K, Sasaki AT, Ha H, Seung HA, Firtel R. Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium. J Biol Chem. 2007 Apr 20; 282(16):11874-84. PMID: 17331950.
      View in: PubMed
    39. Charest PG, Firtel R. Big roles for small GTPases in the control of directed cell movement. Biochem J. 2007 Jan 15; 401(2):377-90. PMID: 17173542; PMCID: PMC1820805.
    40. Charest PG, Firtel R. Feedback signaling controls leading-edge formation during chemotaxis. Curr Opin Genet Dev. 2006 Aug; 16(4):339-47. PMID: 16806895.
      View in: PubMed
    41. Sasaki AT, Firtel R. Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur J Cell Biol. 2006 Sep; 85(9-10):873-95. PMID: 16740339.
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    42. Mendoza MC, Firtel R. Assaying chemotaxis of Dictyostelium cells. Methods Mol Biol. 2006; 346:393-405. PMID: 16957303.
      View in: PubMed
    43. Mendoza MC, Du F, Iranfar N, Tang N, Ma H, Loomis WF, Firtel R. Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Mol Cell Biol. 2005 Sep; 25(17):7839-53. PMID: 16107728; PMCID: PMC1190274.
    44. Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR, Parent CA, Firtel R. TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell. 2005 Oct; 16(10):4572-83. PMID: 16079174; PMCID: PMC1237065.
    45. Meili R, Sasaki AT, Firtel R. Rho Rocks PTEN. Nat Cell Biol. 2005 Apr; 7(4):334-5. PMID: 15803130.
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    46. Myers SA, Han JW, Lee Y, Firtel R, Chung CY. A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol Biol Cell. 2005 May; 16(5):2191-206. PMID: 15728724; PMCID: PMC1087228.
    47. Sasaki AT, Firtel R. Finding the way: directional sensing and cell polarization through Ras signalling. Novartis Found Symp. 2005; 269:73-87; discussion 87-91, 223-30. PMID: 16355536.
      View in: PubMed
    48. Sasaki AT, Chun C, Takeda K, Firtel R. Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol. 2004 Nov 08; 167(3):505-18. PMID: 15534002; PMCID: PMC2172490.
    49. Lee S, Rivero F, Park KC, Huang E, Funamoto S, Firtel R. Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell. 2004 Dec; 15(12):5456-69. PMID: 15483055; PMCID: PMC532025.
    50. Park KC, Rivero F, Meili R, Lee S, Apone F, Firtel R. Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J. 2004 Oct 27; 23(21):4177-89. PMID: 15470506; PMCID: PMC524383.
    51. Kimmel AR, Firtel R. Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response. Curr Opin Genet Dev. 2004 Oct; 14(5):540-9. PMID: 15380246.
      View in: PubMed
    52. Chisholm RL, Firtel R. Insights into morphogenesis from a simple developmental system. Nat Rev Mol Cell Biol. 2004 Jul; 5(7):531-41. PMID: 15232571.
      View in: PubMed
    53. Ridley AJ, Schwartz MA, Burridge K, Firtel R, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. Cell migration: integrating signals from front to back. Science. 2003 Dec 05; 302(5651):1704-9. PMID: 14657486.
      View in: PubMed
    54. Aubry L, Lee S, Ravanel K, Firtel R. The novel ankyrin-repeat containing kinase ARCK-1 acts as a suppressor of the Spalten signaling pathway during Dictyostelium development. Dev Biol. 2003 Nov 15; 263(2):308-22. PMID: 14597204.
      View in: PubMed
    55. Sun B, Ma H, Firtel R. Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton. Mol Biol Cell. 2003 Nov; 14(11):4526-40. PMID: 14593072; PMCID: PMC266770.
    56. Merlot S, Firtel R. Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci. 2003 Sep 01; 116(Pt 17):3471-8. PMID: 12893811.
      View in: PubMed
    57. Meili R, Firtel R. Two poles and a compass. Cell. 2003 Jul 25; 114(2):153-6. PMID: 12887916.
      View in: PubMed
    58. Merlot S, Meili R, Pagliarini DJ, Maehama T, Dixon JE, Firtel R. A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem. 2003 Oct 10; 278(41):39866-73. PMID: 12878591.
      View in: PubMed
    59. Sun B, Firtel R. A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in dictyostelium. Mol Biol Cell. 2003 Apr; 14(4):1727-43. PMID: 12686622; PMCID: PMC153135.
    60. Meili R, Firtel R. Follow the leader. Dev Cell. 2003 Mar; 4(3):291-3. PMID: 12636911.
      View in: PubMed
    61. Huang YE, Iijima M, Parent CA, Funamoto S, Firtel R, Devreotes P. Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell. 2003 May; 14(5):1913-22. PMID: 12802064; PMCID: PMC165086.
    62. Han YH, Chung CY, Wessels D, Stephens S, Titus MA, Soll DR, Firtel R. Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium. J Biol Chem. 2002 Dec 20; 277(51):49877-87. PMID: 12388544.
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    63. Meili R, Firtel R. Leading the way. Nat Cell Biol. 2002 Jul; 4(7):E171. PMID: 12105427.
      View in: PubMed
    64. Sobko A, Ma H, Firtel R. Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev Cell. 2002 Jun; 2(6):745-56. PMID: 12062087.
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    65. Funamoto S, Meili R, Lee S, Parry L, Firtel R. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell. 2002 May 31; 109(5):611-23. PMID: 12062104.
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    66. Chung CY, Firtel R. Signaling pathways at the leading edge of chemotaxing cells. J Muscle Res Cell Motil. 2002; 23(7-8):773-9. PMID: 12952075.
      View in: PubMed
    67. Firtel R, Meili R. Dictyostelium: a model for regulated cell movement during morphogenesis. Curr Opin Genet Dev. 2000 Aug; 10(4):421-7. PMID: 10889066.
      View in: PubMed
    68. Firtel R, Chung CY. The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. Bioessays. 2000 Jul; 22(7):603-15. PMID: 10878573.
      View in: PubMed
    69. Aubry L, Firtel R. Spalten, a protein containing Galpha-protein-like and PP2C domains, is essential for cell-type differentiation in Dictyostelium. Genes Dev. 1998 May 15; 12(10):1525-38. PMID: 9585512; PMCID: PMC316834.
    70. Firtel R. Interacting signaling pathways controlling multicellular development in Dictyostelium. Curr Opin Genet Dev. 1996 Oct; 6(5):545-54. PMID: 8939724.
      View in: PubMed
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