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    Nazneen Dewji

    TitleAssociate Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0681
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Small molecule therapeutics for Alzheimer's Disease
      NIH/NIA R43AG055182Sep 30, 2016 - Aug 31, 2017
      Role: Principal Investigator
      Progressing the Pre-clinical development of P8 for Alzheimer's Disease
      NIH/NIA R44AG043278Aug 1, 2012 - May 31, 2019
      Role: Principal Investigator
      Intranasal Delivery of Peptide Drugs to the Brain
      NIH/NIA R43AG043278Aug 1, 2012 - Nov 30, 2013
      Role: Principal Investigator
      The Presenilins as G-Protein Coupled Receptors
      NIH/NINDS R01NS055161Jun 15, 2007 - Mar 31, 2013
      Role: Principal Investigator
      Mechanisms of beta-Amyloid Precursor Protein Processing in the Brain
      NIH/NINDS R01NS044768Dec 1, 2003 - Nov 30, 2007
      Role: Principal Investigator
      CELLULAR FUNCTIONS OF ALZHEIMER'S DISEASE PROTEINS
      NIH/NIA R01AG017888May 15, 2000 - Apr 30, 2005
      Role: Principal Investigator
      BETA AMYLOID DERIVATION IN BRAIN IN ALZHEIMERS DISEASE
      NIH/NINDS R01NS027580Aug 1, 1989 - Mar 31, 2003
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Dewji N, Singer SJ, Masliah E, Rockenstein E, Kim M, Harber M, Horwood T. Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease. PLoS One. 2015; 10(4):e0122451. PMID: 25923432; PMCID: PMC4414571.
        View in: PubMed, PubMed Central
      2. Dewji N. Presenilin structure in mechanisms leading to Alzheimer's disease. J Alzheimers Dis. 2006 Nov; 10(2-3):277-90. PMID: 17119293.
        View in: PubMed
      3. Dewji N, Mukhopadhyay D, Singer SJ. An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1540-5. PMID: 16432203; PMCID: PMC1345709.
        View in: PubMed, PubMed Central
      4. Singer SJ, Dewji N. Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1546-50. PMID: 16432204; PMCID: PMC1345708.
        View in: PubMed, PubMed Central
      5. Dewji N. The structure and functions of the presenilins. Cell Mol Life Sci. 2005 May; 62(10):1109-19. PMID: 15798893.
        View in: PubMed
      6. Dewji N, Valdez D, Singer SJ. The presenilins turned inside out: implications for their structures and functions. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1057-62. PMID: 14732691; PMCID: PMC327150.
        View in: PubMed, PubMed Central
      7. Dewji N, Singer SJ. Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: its significance for Alzheimer's disease. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15055-60. PMID: 9844014; PMCID: PMC24574.
        View in: PubMed, PubMed Central
      8. Dewji N, Singer SJ. The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14025-30. PMID: 9391146; PMCID: PMC28426.
        View in: PubMed, PubMed Central
      9. Dewji N, Do C, Singer SJ. On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14031-6. PMID: 9391147; PMCID: PMC28427.
        View in: PubMed, PubMed Central
      10. Dewji N, Singer SJ. Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9926-31. PMID: 9275228; PMCID: PMC23298.
        View in: PubMed, PubMed Central
      11. Dewji N, Singer SJ. Specific transcellular binding between membrane proteins crucial to Alzheimer disease. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12575-80. PMID: 8901624; PMCID: PMC38034.
        View in: PubMed, PubMed Central
      12. Dewji N, Singer SJ. Genetic clues to Alzheimer's disease. Science. 1996 Jan 12; 271(5246):159-60. PMID: 8539612.
        View in: PubMed
      13. Dewji N, Do C. Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Brain Res Mol Brain Res. 1996 Jan; 35(1-2):325-8. PMID: 8717371.
        View in: PubMed
      14. Dewji N, Do C, Bayney RM. Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress. Brain Res Mol Brain Res. 1995 Nov; 33(2):245-53. PMID: 8750883.
        View in: PubMed
      15. Trejo J, Massamiri T, Deng T, Dewji N, Bayney RM, Brown JH. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90. PMID: 8063812.
        View in: PubMed
      16. Hall NA, Lake BD, Dewji N, Patrick AD. Lysosomal storage of subunit c of mitochondrial ATP synthase in Batten's disease (ceroid-lipofuscinosis). Biochem J. 1991 Apr 01; 275 ( Pt 1):269-72. PMID: 1826833; PMCID: PMC1150044.
        View in: PubMed, PubMed Central
      17. Adler MJ, Coronel C, Shelton E, Seegmiller JE, Dewji N. Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):16-20. PMID: 1702541; PMCID: PMC50738.
        View in: PubMed, PubMed Central
      18. Dewji N, Shelton ER, Adler MJ, Chan HW, Seegmiller JE, Coronel C. Processing of Alzheimer's disease-associated beta-amyloid precursor protein. J Mol Neurosci. 1990; 2(1):19-27. PMID: 2124135.
        View in: PubMed
      19. O'Brien JS, Kretz KA, Dewji N, Wenger DA, Esch F, Fluharty AL. Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus. Science. 1988 Aug 26; 241(4869):1098-101. PMID: 2842863.
        View in: PubMed
      20. Dewji N, Wenger DA, O'Brien JS. Nucleotide sequence of cloned cDNA for human sphingolipid activator protein 1 precursor. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8652-6. PMID: 2825202; PMCID: PMC299604.
        View in: PubMed, PubMed Central
      21. Kao FT, Law ML, Hartz J, Jones C, Zhang XL, Dewji N, O'Brien JS, Wenger DA. Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10. Somat Cell Mol Genet. 1987 Nov; 13(6):685-8. PMID: 3478817.
        View in: PubMed
      22. Dewji N, De-Keyzer DR, Stirling JL. Purification and characterization of beta-N-acetylhexosaminidase I2 from human liver. Biochem J. 1986 Feb 15; 234(1):157-62. PMID: 2423070; PMCID: PMC1146539.
        View in: PubMed, PubMed Central
      23. Dewji N, Wenger D, Fujibayashi S, Donoviel M, Esch F, Hill F, O'Brien JS. Molecular cloning of the sphingolipid activator protein-1 (SAP-1), the sulfatide sulfatase activator. Biochem Biophys Res Commun. 1986 Jan 29; 134(2):989-94. PMID: 2868718.
        View in: PubMed
      24. de Wet JR, Fukushima H, Dewji N, Wilcox E, O'Brien JS, Helinski DR. Chromogenic immunodetection of human serum albumin and alpha-L-fucosidase clones in a human hepatoma cDNA expression library. DNA. 1984 Dec; 3(6):437-47. PMID: 6096099.
        View in: PubMed
      25. Wood KV, de Wet JR, Dewji N, DeLuca M. Synthesis of active firefly luciferase by in vitro translation of RNA obtained from adult lanterns. Biochem Biophys Res Commun. 1984 Oct 30; 124(2):592-6. PMID: 6208909.
        View in: PubMed
      26. Dewji N, Rapson N, Greaves M, Ellis R. Isoenzyme profiles of lysosomal hydrolases in leukaemic cells. Leuk Res. 1981; 5(1):19-27. PMID: 6262581.
        View in: PubMed
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