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Nazneen Dewji

Title(s)Associate Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    Small molecule therapeutics for Alzheimer's Disease
    NIH R44AG055182Sep 30, 2016 - May 31, 2020
    Role: Principal Investigator
    Small molecule therapeutics for Alzheimer's Disease
    NIH R43AG055182Sep 30, 2016 - Aug 31, 2018
    Role: Principal Investigator
    IND-Enabling Pre-clinical Development of Modified P8 for the Treatment of Alzheimer's Disease
    NIH R44AG043278Aug 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Intranasal Delivery of Peptide Drugs to the Brain
    NIH R43AG043278Aug 1, 2012 - Nov 30, 2013
    Role: Principal Investigator
    The Presenilins as G-Protein Coupled Receptors
    NIH R01NS055161Jun 15, 2007 - Mar 31, 2013
    Role: Principal Investigator
    Mechanisms of beta-Amyloid Precursor Protein Processing in the Brain
    NIH R01NS044768Dec 1, 2003 - Nov 30, 2007
    Role: Principal Investigator
    CELLULAR FUNCTIONS OF ALZHEIMER'S DISEASE PROTEINS
    NIH R01AG017888May 15, 2000 - Apr 30, 2005
    Role: Principal Investigator
    BETA AMYLOID DERIVATION IN BRAIN IN ALZHEIMERS DISEASE
    NIH R01NS027580Aug 1, 1989 - Mar 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Diabetes knowledge, risk and severity perceptions, lifestyle behaviours and management barriers among Sub-Saharan African immigrants living in the UK: an ethnographic study. BMC Public Health. 2025 Aug 22; 25(1):2883. Onuorah L, Santy-Tomlinson J, Draper P. PMID: 40846934; PMCID: PMC12372270.
      View in: PubMed   Mentions:    Fields:    
    2. Graduate Students' Perspectives on Obtaining a Master's of Science in Respiratory Care. Respir Care. 2025 04; 70(4):384-392. Koster MS, McHenry KL, Caldwell-Chadwick BG, Null MM. PMID: 40193534.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Comparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system. BJPsych Open. 2025 Mar 10; 11(2):e42. He L, Yu W, Song H, Li L, Shen Y, Zhang L, Li H. PMID: 40059385; PMCID: PMC12001931.
      View in: PubMed   Mentions:
    4. Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects. Am J Psychiatry. 2024 Jul 01; 181(7):639-650. Ironside M, Duda JM, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Chen X, Chen X, Nickerson LD, Null KE, Esfand SM, Alexander MM, Crowley DJ, Lauze M, Misra M, Goldstein JM, Pizzagalli DA. PMID: 38685857; PMCID: PMC11216878.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. [Determination of trace anions in battery-grade lithium carbonate by double-inhibition on-line matrix-removal ion chromatography]. Se Pu. 2024 Mar 08; 42(3):291-295. Wu G, Wu GQ. PMID: 38503706; PMCID: PMC10951807.
      View in: PubMed   Mentions:    Fields:    
    6. Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity. Autophagy. 2023 08; 19(8):2257-2274. Li J, Li J, Zhou Y, Zhao W, Zhao W, Liu J, Ullah R, Fang P, Fang L, Xiao S. PMID: 36779599; PMCID: PMC10351467.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    7. [Determination of organophosphate diesters in facility vegetable soils using ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2023 Jan; 41(1):58-65. Liu M, Wang M, Zhao A, Zhao A, Zhu L, Wang C, Wei C, Liu W, Xu J. PMID: 36633077; PMCID: PMC9837671.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. [Simultaneous determination of 28 fragrance components in cosmetics by gas chromatography-tandem mass spectrometry]. Se Pu. 2023 Jan; 41(1):76-86. Xu D, Wu Y, Wang Y, Chen F, Chen F, Zhang S, Lai G. PMID: 36633079; PMCID: PMC9841437.
      View in: PubMed   Mentions: 1     Fields:    
    9. DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease. Autophagy. 2023 07; 19(7):2166-2169. Montégut L, Joseph A, Chen H, Chen H, Abdellatif M, Ruckenstuhl C, Martins I, Madeo F, Kroemer G. PMID: 36579946; PMCID: PMC10283417.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    10. Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol. 2022 Sep; 24(9):1445. Gil J, Bernard D, Martínez D, Beach D. PMID: 35941232.
      View in: PubMed   Mentions: 1     Fields:    
    11. [Plasma metabolomics in a deep vein thrombosis rat model based on ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2022 Aug; 40(8):736-745. Gu Y, Zang P, Li J, Li J, Yan Y, Wang J. PMID: 35903841; PMCID: PMC9404070.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    12. Autophagy and its mediated mitochondrial quality control maintain pollen tube growth and male fertility in Arabidopsis. Autophagy. 2023 03; 19(3):768-783. Yan H, Zhuang M, Xu X, Li S, Li S, Yang M, Li N, Du X, Hu K, Peng X, Huang W, Wu H, Tse YC, Zhao L, Wang H. PMID: 35786359; PMCID: PMC9980518.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Uniform criteria for total hip replacement surgery in patients with hip osteoarthritis: a decision tool to guide treatment decisions. Int J Qual Health Care. 2021 Mar 04; 33(1). Atsma F, Molenkamp O, Bouma H, Bolder SB, Groenewoud AS, Westert GP. PMID: 33616656; PMCID: PMC7941208.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Injury, Illness, and Mental Health Risks in United States Domestic Mariners. J Occup Environ Med. 2020 10; 62(10):839-841. Lefkowitz RY, Null DB, Slade MD, Redlich CA. PMID: 32769797.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Imaging examination, diagnosis, and control and prevention of nosocomial infection for coronavirus disease 2019: Expert consensus of Hunan radiologist. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28; 45(3):221-228. Liu J, Liu J, Wang W. PMID: 32386011.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    16. Pharmacokinetics in Rat of P8, a Peptide Drug Candidate for the Treatment of Alzheimer's Disease: Stability and Delivery to the Brain. J Alzheimers Dis Rep. 2018 Oct 24; 2(1):169-179. Dewji NN, Azar MR, Hanson LR, Frey Ii WH, Morimoto BH, Johnson D. PMID: 30480260; PMCID: PMC6218153.
      View in: PubMed   Mentions: 3  
    17. Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease. PLoS One. 2015; 10(4):e0122451. Dewji NN, Singer SJ, Masliah E, Rockenstein E, Kim M, Harber M, Horwood T. PMID: 25923432; PMCID: PMC4414571.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Presenilin structure in mechanisms leading to Alzheimer's disease. J Alzheimers Dis. 2006 Nov; 10(2-3):277-90. Dewji NN. PMID: 17119293.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1546-50. Singer SJ, Dewji NN. PMID: 16432204; PMCID: PMC1345708.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    20. An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1540-5. Dewji NN, Mukhopadhyay D, Singer SJ. PMID: 16432203; PMCID: PMC1345709.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. The structure and functions of the presenilins. Cell Mol Life Sci. 2005 May; 62(10):1109-19. Dewji NN. PMID: 15798893; PMCID: PMC11138377.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. The presenilins turned inside out: implications for their structures and functions. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1057-62. Dewji NN, Valdez D, Singer SJ. PMID: 14732691; PMCID: PMC327150.
      View in: PubMed   Mentions: 11     Fields:    
    23. Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: its significance for Alzheimer's disease. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15055-60. Dewji NN, Singer SJ. PMID: 9844014; PMCID: PMC24574.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14031-6. Dewji NN, Do C, Singer SJ. PMID: 9391147; PMCID: PMC28427.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14025-30. Dewji NN, Singer SJ. PMID: 9391146; PMCID: PMC28426.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    26. Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9926-31. Dewji NN, Singer SJ. PMID: 9275228; PMCID: PMC23298.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    27. Specific transcellular binding between membrane proteins crucial to Alzheimer disease. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12575-80. Dewji NN, Singer SJ. PMID: 8901624; PMCID: PMC38034.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    28. Genetic clues to Alzheimer's disease. Science. 1996 Jan 12; 271(5246):159-60. Dewji NN, Singer SJ. PMID: 8539612.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Brain Res Mol Brain Res. 1996 Jan; 35(1-2):325-8. Dewji NN, Do C. PMID: 8717371.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    30. Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress. Brain Res Mol Brain Res. 1995 Nov; 33(2):245-53. Dewji NN, Do C, Bayney RM. PMID: 8750883.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    31. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90. Trejo J, Massamiri T, Deng T, Dewji NN, Bayney RM, Brown JH. PMID: 8063812.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    32. Lysosomal storage of subunit c of mitochondrial ATP synthase in Batten's disease (ceroid-lipofuscinosis). Biochem J. 1991 Apr 01; 275 ( Pt 1):269-72. Hall NA, Lake BD, Dewji NN, Patrick AD. PMID: 1826833; PMCID: PMC1150044.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    33. Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):16-20. Adler MJ, Coronel C, Shelton E, Seegmiller JE, Dewji NN. PMID: 1702541; PMCID: PMC50738.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    34. Processing of Alzheimer's disease-associated beta-amyloid precursor protein. J Mol Neurosci. 1990; 2(1):19-27. Dewji NN, Shelton ER, Adler MJ, Chan HW, Seegmiller JE, Coronel C. PMID: 2124135.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus. Science. 1988 Aug 26; 241(4869):1098-101. O'Brien JS, Kretz KA, Dewji N, Wenger DA, Esch F, Fluharty AL. PMID: 2842863.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    36. Nucleotide sequence of cloned cDNA for human sphingolipid activator protein 1 precursor. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8652-6. Dewji NN, Wenger DA, O'Brien JS. PMID: 2825202; PMCID: PMC299604.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10. Somat Cell Mol Genet. 1987 Nov; 13(6):685-8. Kao FT, Law ML, Hartz J, Jones C, Zhang XL, Dewji N, O'Brien JS, Wenger DA. PMID: 3478817.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    38. Purification and characterization of beta-N-acetylhexosaminidase I2 from human liver. Biochem J. 1986 Feb 15; 234(1):157-62. Dewji NN, De-Keyzer DR, Stirling JL. PMID: 2423070; PMCID: PMC1146539.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Molecular cloning of the sphingolipid activator protein-1 (SAP-1), the sulfatide sulfatase activator. Biochem Biophys Res Commun. 1986 Jan 29; 134(2):989-94. Dewji N, Wenger D, Fujibayashi S, Donoviel M, Esch F, Hill F, O'Brien JS. PMID: 2868718.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    40. Chromogenic immunodetection of human serum albumin and alpha-L-fucosidase clones in a human hepatoma cDNA expression library. DNA. 1984 Dec; 3(6):437-47. de Wet JR, Fukushima H, Dewji NN, Wilcox E, O'Brien JS, Helinski DR. PMID: 6096099.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    41. Synthesis of active firefly luciferase by in vitro translation of RNA obtained from adult lanterns. Biochem Biophys Res Commun. 1984 Oct 30; 124(2):592-6. Wood KV, de Wet JR, Dewji N, DeLuca M. PMID: 6208909.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    42. Isoenzyme profiles of lysosomal hydrolases in leukaemic cells. Leuk Res. 1981; 5(1):19-27. Dewji N, Rapson N, Greaves M, Ellis R. PMID: 6262581.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
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