Nazneen Dewji

Title(s)Associate Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Small molecule therapeutics for Alzheimer's Disease
    NIH R44AG055182Sep 30, 2016 - May 31, 2020
    Role: Principal Investigator
    Small molecule therapeutics for Alzheimer's Disease
    NIH R43AG055182Sep 30, 2016 - Aug 31, 2018
    Role: Principal Investigator
    IND-Enabling Pre-clinical Development of Modified P8 for the Treatment of Alzheimer's Disease
    NIH R44AG043278Aug 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Intranasal Delivery of Peptide Drugs to the Brain
    NIH R43AG043278Aug 1, 2012 - Nov 30, 2013
    Role: Principal Investigator
    The Presenilins as G-Protein Coupled Receptors
    NIH R01NS055161Jun 15, 2007 - Mar 31, 2013
    Role: Principal Investigator
    Mechanisms of beta-Amyloid Precursor Protein Processing in the Brain
    NIH R01NS044768Dec 1, 2003 - Nov 30, 2007
    Role: Principal Investigator
    CELLULAR FUNCTIONS OF ALZHEIMER'S DISEASE PROTEINS
    NIH R01AG017888May 15, 2000 - Apr 30, 2005
    Role: Principal Investigator
    BETA AMYLOID DERIVATION IN BRAIN IN ALZHEIMERS DISEASE
    NIH R01NS027580Aug 1, 1989 - Mar 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pharmacokinetics in Rat of P8, a Peptide Drug Candidate for the Treatment of Alzheimer's Disease: Stability and Delivery to the Brain. J Alzheimers Dis Rep. 2018 Oct 24; 2(1):169-179. Dewji NN, Azar MR, Hanson LR, Frey Ii WH, Morimoto BH, Johnson D. PMID: 30480260; PMCID: PMC6218153.
      View in: PubMed   Mentions: 2  
    2. Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease. PLoS One. 2015; 10(4):e0122451. Dewji NN, Singer SJ, Masliah E, Rockenstein E, Kim M, Harber M, Horwood T. PMID: 25923432; PMCID: PMC4414571.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Presenilin structure in mechanisms leading to Alzheimer's disease. J Alzheimers Dis. 2006 Nov; 10(2-3):277-90. Dewji NN. PMID: 17119293.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1540-5. Dewji NN, Mukhopadhyay D, Singer SJ. PMID: 16432203; PMCID: PMC1345709.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1546-50. Singer SJ, Dewji NN. PMID: 16432204; PMCID: PMC1345708.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    6. The structure and functions of the presenilins. Cell Mol Life Sci. 2005 May; 62(10):1109-19. Dewji NN. PMID: 15798893.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. The presenilins turned inside out: implications for their structures and functions. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1057-62. Dewji NN, Valdez D, Singer SJ. PMID: 14732691; PMCID: PMC327150.
      View in: PubMed   Mentions: 11     Fields:    
    8. Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: its significance for Alzheimer's disease. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15055-60. Dewji NN, Singer SJ. PMID: 9844014; PMCID: PMC24574.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14025-30. Dewji NN, Singer SJ. PMID: 9391146; PMCID: PMC28426.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    10. On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14031-6. Dewji NN, Do C, Singer SJ. PMID: 9391147; PMCID: PMC28427.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9926-31. Dewji NN, Singer SJ. PMID: 9275228; PMCID: PMC23298.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    12. Specific transcellular binding between membrane proteins crucial to Alzheimer disease. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12575-80. Dewji NN, Singer SJ. PMID: 8901624; PMCID: PMC38034.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    13. Genetic clues to Alzheimer's disease. Science. 1996 Jan 12; 271(5246):159-60. Dewji NN, Singer SJ. PMID: 8539612.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    14. Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Brain Res Mol Brain Res. 1996 Jan; 35(1-2):325-8. Dewji NN, Do C. PMID: 8717371.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress. Brain Res Mol Brain Res. 1995 Nov; 33(2):245-53. Dewji NN, Do C, Bayney RM. PMID: 8750883.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    16. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90. Trejo J, Massamiri T, Deng T, Dewji NN, Bayney RM, Brown JH. PMID: 8063812.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    17. Lysosomal storage of subunit c of mitochondrial ATP synthase in Batten's disease (ceroid-lipofuscinosis). Biochem J. 1991 Apr 01; 275 ( Pt 1):269-72. Hall NA, Lake BD, Dewji NN, Patrick AD. PMID: 1826833; PMCID: PMC1150044.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    18. Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):16-20. Adler MJ, Coronel C, Shelton E, Seegmiller JE, Dewji NN. PMID: 1702541; PMCID: PMC50738.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    19. Processing of Alzheimer's disease-associated beta-amyloid precursor protein. J Mol Neurosci. 1990; 2(1):19-27. Dewji NN, Shelton ER, Adler MJ, Chan HW, Seegmiller JE, Coronel C. PMID: 2124135.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus. Science. 1988 Aug 26; 241(4869):1098-101. O'Brien JS, Kretz KA, Dewji N, Wenger DA, Esch F, Fluharty AL. PMID: 2842863.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    21. Nucleotide sequence of cloned cDNA for human sphingolipid activator protein 1 precursor. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8652-6. Dewji NN, Wenger DA, O'Brien JS. PMID: 2825202; PMCID: PMC299604.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    22. Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10. Somat Cell Mol Genet. 1987 Nov; 13(6):685-8. Kao FT, Law ML, Hartz J, Jones C, Zhang XL, Dewji N, O'Brien JS, Wenger DA. PMID: 3478817.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Purification and characterization of beta-N-acetylhexosaminidase I2 from human liver. Biochem J. 1986 Feb 15; 234(1):157-62. Dewji NN, De-Keyzer DR, Stirling JL. PMID: 2423070; PMCID: PMC1146539.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Molecular cloning of the sphingolipid activator protein-1 (SAP-1), the sulfatide sulfatase activator. Biochem Biophys Res Commun. 1986 Jan 29; 134(2):989-94. Dewji N, Wenger D, Fujibayashi S, Donoviel M, Esch F, Hill F, O'Brien JS. PMID: 2868718.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. Chromogenic immunodetection of human serum albumin and alpha-L-fucosidase clones in a human hepatoma cDNA expression library. DNA. 1984 Dec; 3(6):437-47. de Wet JR, Fukushima H, Dewji NN, Wilcox E, O'Brien JS, Helinski DR. PMID: 6096099.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    26. Synthesis of active firefly luciferase by in vitro translation of RNA obtained from adult lanterns. Biochem Biophys Res Commun. 1984 Oct 30; 124(2):592-6. Wood KV, de Wet JR, Dewji N, DeLuca M. PMID: 6208909.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    27. Isoenzyme profiles of lysosomal hydrolases in leukaemic cells. Leuk Res. 1981; 5(1):19-27. Dewji N, Rapson N, Greaves M, Ellis R. PMID: 6262581.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
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