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Nazneen Dewji

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0681
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Small molecule therapeutics for Alzheimer's Disease
    NIH/NIA R43AG055182Sep 30, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Progressing the Pre-clinical development of P8 for Alzheimer's Disease
    NIH/NIA R44AG043278Aug 1, 2012 - May 31, 2019
    Role: Principal Investigator
    Intranasal Delivery of Peptide Drugs to the Brain
    NIH/NIA R43AG043278Aug 1, 2012 - Nov 30, 2013
    Role: Principal Investigator
    The Presenilins as G-Protein Coupled Receptors
    NIH/NINDS R01NS055161Jun 15, 2007 - Mar 31, 2013
    Role: Principal Investigator
    Mechanisms of beta-Amyloid Precursor Protein Processing in the Brain
    NIH/NINDS R01NS044768Dec 1, 2003 - Nov 30, 2007
    Role: Principal Investigator
    CELLULAR FUNCTIONS OF ALZHEIMER'S DISEASE PROTEINS
    NIH/NIA R01AG017888May 15, 2000 - Apr 30, 2005
    Role: Principal Investigator
    BETA AMYLOID DERIVATION IN BRAIN IN ALZHEIMERS DISEASE
    NIH/NINDS R01NS027580Aug 1, 1989 - Mar 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dewji N, Singer SJ, Masliah E, Rockenstein E, Kim M, Harber M, Horwood T. Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease. PLoS One. 2015; 10(4):e0122451. PMID: 25923432; PMCID: PMC4414571.
    2. Dewji N. Presenilin structure in mechanisms leading to Alzheimer's disease. J Alzheimers Dis. 2006 Nov; 10(2-3):277-90. PMID: 17119293.
      View in: PubMed
    3. Singer SJ, Dewji N. Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1546-50. PMID: 16432204; PMCID: PMC1345708.
    4. Dewji N, Mukhopadhyay D, Singer SJ. An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1540-5. PMID: 16432203; PMCID: PMC1345709.
    5. Dewji N. The structure and functions of the presenilins. Cell Mol Life Sci. 2005 May; 62(10):1109-19. PMID: 15798893.
      View in: PubMed
    6. Dewji N, Valdez D, Singer SJ. The presenilins turned inside out: implications for their structures and functions. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1057-62. PMID: 14732691; PMCID: PMC327150.
    7. Dewji N, Singer SJ. Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: its significance for Alzheimer's disease. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15055-60. PMID: 9844014; PMCID: PMC24574.
    8. Dewji N, Do C, Singer SJ. On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14031-6. PMID: 9391147; PMCID: PMC28427.
    9. Dewji N, Singer SJ. The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14025-30. PMID: 9391146; PMCID: PMC28426.
    10. Dewji N, Singer SJ. Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9926-31. PMID: 9275228; PMCID: PMC23298.
    11. Dewji N, Singer SJ. Specific transcellular binding between membrane proteins crucial to Alzheimer disease. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12575-80. PMID: 8901624; PMCID: PMC38034.
    12. Dewji N, Singer SJ. Genetic clues to Alzheimer's disease. Science. 1996 Jan 12; 271(5246):159-60. PMID: 8539612.
      View in: PubMed
    13. Dewji N, Do C. Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Brain Res Mol Brain Res. 1996 Jan; 35(1-2):325-8. PMID: 8717371.
      View in: PubMed
    14. Dewji N, Do C, Bayney RM. Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress. Brain Res Mol Brain Res. 1995 Nov; 33(2):245-53. PMID: 8750883.
      View in: PubMed
    15. Trejo J, Massamiri T, Deng T, Dewji N, Bayney RM, Brown JH. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90. PMID: 8063812.
      View in: PubMed
    16. Adler MJ, Coronel C, Shelton E, Seegmiller JE, Dewji N. Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):16-20. PMID: 1702541; PMCID: PMC50738.
    17. Dewji N, Shelton ER, Adler MJ, Chan HW, Seegmiller JE, Coronel C. Processing of Alzheimer's disease-associated beta-amyloid precursor protein. J Mol Neurosci. 1990; 2(1):19-27. PMID: 2124135.
      View in: PubMed
    18. O'Brien JS, Kretz KA, Dewji N, Wenger DA, Esch F, Fluharty AL. Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus. Science. 1988 Aug 26; 241(4869):1098-101. PMID: 2842863.
      View in: PubMed
    19. Dewji N, Wenger DA, O'Brien JS. Nucleotide sequence of cloned cDNA for human sphingolipid activator protein 1 precursor. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8652-6. PMID: 2825202; PMCID: PMC299604.
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