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    Jens Lykke-Andersen

    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0322
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Mechanisms of human RNA turnover and quality control
      NIH/NIGMS R35GM118069Jun 1, 2016 - May 31, 2021
      Role: Principal Investigator
      Mechanisms of mRNP remodeling in mRNA turnover
      NIH/NIGMS R01GM099717Feb 1, 2012 - Jan 31, 2016
      Role: Principal Investigator
      Mechanisms of activation of human mRNA decapping
      NIH/NIGMS R01GM077243Aug 13, 2007 - May 31, 2017
      Role: Principal Investigator
      Deadenylation in Mammalian mRNA Turnover
      NIH/NIGMS R01GM066811Apr 1, 2004 - Mar 31, 2010
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çaglayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464. PMID: 28092684.
        View in: PubMed
      2. D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA. A human microprotein that interacts with the mRNA decapping complex. Nat Chem Biol. 2017 Feb; 13(2):174-180. PMID: 27918561.
        View in: PubMed
      3. Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, Lardelli R, Sundararaman B, Donohue JP, Javaherian A, Lykke-Andersen J, Finkbeiner S, Bennett CF, Ares M, Burge CB, Taylor JP, Rigo F, Yeo GW. Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Neuron. 2016 Nov 23; 92(4):780-795. PMID: 27773581.
        View in: PubMed
      4. Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J. The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation. Mol Cell Biol. 2016 Sep 01; 36(17):2226-35. PMID: 27247266; PMCID: PMC4985932 [Available on 02/12/17].
      5. Durand S, Franks TM, Lykke-Andersen J. Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. Nat Commun. 2016 Aug 11; 7:12434. PMID: 27511142; PMCID: PMC4987530.
      6. Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J. Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements. RNA. 2016 Mar; 22(3):373-82. PMID: 26763119; PMCID: PMC4748815 [Available on 03/01/17].
      7. Wang Y, Arribas-Layton M, Chen Y, Lykke-Andersen J, Sen GL. DDX6 Orchestrates Mammalian Progenitor Function through the mRNA Degradation and Translation Pathways. Mol Cell. 2015 Oct 01; 60(1):118-30. PMID: 26412305; PMCID: PMC4592480 [Available on 10/01/16].
      8. Lee SR, Pratt GA, Martinez FJ, Yeo GW, Lykke-Andersen J. Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. Mol Cell. 2015 Aug 06; 59(3):413-25. PMID: 26253027; PMCID: PMC4673969.
      9. Erickson SL, Corpuz EO, Maloy JP, Fillman C, Webb K, Bennett EJ, Lykke-Andersen J. Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity. Mol Cell Biol. 2015 Jun; 35(12):2144-53. PMID: 25870104; PMCID: PMC4438239.
      10. Hausburg MA, Doles JD, Clement SL, Cadwallader AB, Hall MN, Blackshear PJ, Lykke-Andersen J, Olwin BB. Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. Elife. 2015 Mar 27; 4:e03390. PMID: 25815583; PMCID: PMC4415119.
      11. Toma KG, Rebbapragada I, Durand S, Lykke-Andersen J. Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay. RNA. 2015 May; 21(5):887-97. PMID: 25805855; PMCID: PMC4408796.
      12. Reznik B, Clement SL, Lykke-Andersen J. hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay. PLoS One. 2014; 9(6):e100992. PMID: 24978456; PMCID: PMC4076271.
      13. Lykke-Andersen J, Bennett EJ. Protecting the proteome: Eukaryotic cotranslational quality control pathways. J Cell Biol. 2014 Feb 17; 204(4):467-76. PMID: 24535822; PMCID: PMC3926952.
      14. Lee SR, Lykke-Andersen J. Emerging roles for ribonucleoprotein modification and remodeling in controlling RNA fate. Trends Cell Biol. 2013 Oct; 23(10):504-10. PMID: 23756094; PMCID: PMC3983964.
      15. Durand S, Lykke-Andersen J. Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells. Nat Struct Mol Biol. 2013 Jun; 20(6):702-9. PMID: 23665580.
        View in: PubMed
      16. Damgaard CK, Lykke-Andersen J. Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer. Cancer Treat Res. 2013; 158:153-80. PMID: 24222358.
        View in: PubMed
      17. Brannan K, Kim H, Erickson B, Glover-Cutter K, Kim S, Fong N, Kiemele L, Hansen K, Davis R, Lykke-Andersen J, Bentley DL. mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription. Mol Cell. 2012 May 11; 46(3):311-24. PMID: 22483619; PMCID: PMC3806456.
      18. Damgaard CK, Lykke-Andersen J. Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev. 2011 Oct 01; 25(19):2057-68. PMID: 21979918; PMCID: PMC3197204.
      19. Durand S, Lykke-Andersen J. SnapShot: Nonsense-mediated mRNA decay. Cell. 2011 Apr 15; 145(2):324-324.e2. PMID: 21496649.
        View in: PubMed
      20. Erickson SL, Lykke-Andersen J. Cytoplasmic mRNP granules at a glance. J Cell Sci. 2011 Feb 01; 124(Pt 3):293-7. PMID: 21242308; PMCID: PMC3021993.
      21. Franks TM, Singh G, Lykke-Andersen J. Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell. 2010 Dec 10; 143(6):938-50. PMID: 21145460; PMCID: PMC3357093.
      22. Reznik B, Lykke-Andersen J. Regulated and quality-control mRNA turnover pathways in eukaryotes. Biochem Soc Trans. 2010 Dec; 38(6):1506-10. PMID: 21118116.
        View in: PubMed
      23. Clement SL, Scheckel C, Stoecklin G, Lykke-Andersen J. Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment. Mol Cell Biol. 2011 Jan; 31(2):256-66. PMID: 21078877; PMCID: PMC3019984.
      24. Mühlemann O, Lykke-Andersen J. How and where are nonsense mRNAs degraded in mammalian cells? RNA Biol. 2010 Jan-Feb; 7(1):28-32. PMID: 20023408; PMCID: PMC4049745.
      25. Rebbapragada I, Lykke-Andersen J. Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol. 2009 Jun; 21(3):394-402. PMID: 19359157.
        View in: PubMed
      26. Franks TM, Lykke-Andersen J. The control of mRNA decapping and P-body formation. Mol Cell. 2008 Dec 05; 32(5):605-15. PMID: 19061636; PMCID: PMC2630519.
      27. Singh G, Rebbapragada I, Lykke-Andersen J. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol. 2008 Apr 29; 6(4):e111. PMID: 18447585; PMCID: PMC2689706.
      28. Clement SL, Lykke-Andersen J. A tethering approach to study proteins that activate mRNA turnover in human cells. Methods Mol Biol. 2008; 419:121-33. PMID: 18369979.
        View in: PubMed
      29. Singh G, Jakob S, Kleedehn MG, Lykke-Andersen J. Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Mol Cell. 2007 Sep 07; 27(5):780-92. PMID: 17803942.
        View in: PubMed
      30. Franks TM, Lykke-Andersen J. TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev. 2007 Mar 15; 21(6):719-35. PMID: 17369404; PMCID: PMC1820945.
      31. Wagner E, Clement SL, Lykke-Andersen J. An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Mol Cell Biol. 2007 Mar; 27(5):1686-95. PMID: 17178830; PMCID: PMC1820451.
      32. Clement SL, Lykke-Andersen J. No mercy for messages that mess with the ribosome. Nat Struct Mol Biol. 2006 Apr; 13(4):299-301. PMID: 16715045.
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      33. Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell. 2005 Dec 22; 20(6):905-15. PMID: 16364915.
        View in: PubMed
      34. Weischenfeldt J, Lykke-Andersen J, Porse B. Messenger RNA surveillance: neutralizing natural nonsense. Curr Biol. 2005 Jul 26; 15(14):R559-62. PMID: 16051166.
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      35. Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol. 2005 Jun 20; 169(6):871-84. PMID: 15967811; PMCID: PMC2171635.
      36. Fillman C, Lykke-Andersen J. RNA decapping inside and outside of processing bodies. Curr Opin Cell Biol. 2005 Jun; 17(3):326-31. PMID: 15901504.
        View in: PubMed
      37. Lykke-Andersen J, Wagner E. Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev. 2005 Feb 01; 19(3):351-61. PMID: 15687258; PMCID: PMC546513.
      38. Lykke-Andersen J. Making structural sense of nonsense-mediated decay. Nat Struct Mol Biol. 2004 Apr; 11(4):305-6. PMID: 15048104.
        View in: PubMed
      39. Nielsen J, Adolph SK, Rajpert-De Meyts E, Lykke-Andersen J, Koch G, Christiansen J, Nielsen FC. Nuclear transit of human zipcode-binding protein IMP1. Biochem J. 2003 Dec 01; 376(Pt 2):383-91. PMID: 12921532; PMCID: PMC1223771.
      40. Singh G, Lykke-Andersen J. New insights into the formation of active nonsense-mediated decay complexes. Trends Biochem Sci. 2003 Sep; 28(9):464-6. PMID: 13678954.
        View in: PubMed
      41. Lykke-Andersen J. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol. 2002 Dec; 22(23):8114-21. PMID: 12417715; PMCID: PMC134073.
      42. Wagner E, Lykke-Andersen J. mRNA surveillance: the perfect persist. J Cell Sci. 2002 Aug 01; 115(Pt 15):3033-8. PMID: 12118059.
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      43. Lykke-Andersen J, Shu MD, Steitz JA. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science. 2001 Sep 07; 293(5536):1836-9. PMID: 11546874.
        View in: PubMed
      44. Lykke-Andersen J. mRNA quality control: Marking the message for life or death. Curr Biol. 2001 Feb 06; 11(3):R88-91. PMID: 11231165.
        View in: PubMed
      45. Lykke-Andersen J, Shu MD, Steitz JA. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell. 2000 Dec 22; 103(7):1121-31. PMID: 11163187.
        View in: PubMed
      46. Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J. H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. J Biol Chem. 2000 Sep 22; 275(38):29562-9. PMID: 10875929.
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      47. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol. 1999 Feb; 19(2):1262-70. PMID: 9891060; PMCID: PMC116055.
      48. Lykke-Andersen J, Christiansen J. The C-terminal carboxy group of T7 RNA polymerase ensures efficient magnesium ion-dependent catalysis. Nucleic Acids Res. 1998 Dec 15; 26(24):5630-5. PMID: 9837993; PMCID: PMC148041.
      49. Lykke-Andersen J, Garrett RA. RNA-protein interactions of an archaeal homotetrameric splicing endoribonuclease with an exceptional evolutionary history. EMBO J. 1997 Oct 15; 16(20):6290-300. PMID: 9321408; PMCID: PMC1326313.
      50. Lykke-Andersen J, Aagaard C, Semionenkov M, Garrett RA. Archaeal introns: splicing, intercellular mobility and evolution. Trends Biochem Sci. 1997 Sep; 22(9):326-31. PMID: 9301331.
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      51. Lykke-Andersen J, Garrett RA, Kjems J. Mapping metal ions at the catalytic centres of two intron-encoded endonucleases. EMBO J. 1997 Jun 02; 16(11):3272-81. PMID: 9214642; PMCID: PMC1169943.
      52. Lykke-Andersen J, Garrett RA, Kjems J. Protein footprinting approach to mapping DNA binding sites of two archaeal homing enzymes: evidence for a two-domain protein structure. Nucleic Acids Res. 1996 Oct 15; 24(20):3982-9. PMID: 8918801; PMCID: PMC146195.
      53. Lykke-Andersen J, Garrett RA. Structural characteristics of the stable RNA introns of archaeal hyperthermophiles and their splicing junctions. J Mol Biol. 1994 Nov 11; 243(5):846-55. PMID: 7966305.
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      54. Lykke-Andersen J, Thi-Ngoc HP, Garrett RA. DNA substrate specificity and cleavage kinetics of an archaeal homing-type endonuclease from Pyrobaculum organotrophum. Nucleic Acids Res. 1994 Nov 11; 22(22):4583-90. PMID: 7984405; PMCID: PMC308504.
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