Jens Lykke-andersen

Title(s)Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Mechanisms of human RNA turnover and quality control
    NIH R35GM118069Jun 1, 2016 - May 31, 2026
    Role: Principal Investigator
    Mechanisms of mRNP remodeling in mRNA turnover
    NIH R01GM099717Feb 1, 2012 - Jan 31, 2016
    Role: Principal Investigator
    Mechanisms of activation of human mRNA decapping
    NIH R01GM077243Aug 13, 2007 - May 31, 2017
    Role: Principal Investigator
    Deadenylation in Mammalian mRNA Turnover
    NIH R01GM066811Apr 1, 2004 - Mar 31, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Assigning functionality to cysteines by base editing of cancer dependency genes. Nat Chem Biol. 2023 Nov; 19(11):1320-1330. Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF. PMID: 37783940; PMCID: PMC10698195.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. The 3' exonuclease TOE1 selectively processes snRNAs through recognition of Sm complex assembly and 5' cap trimethylation. bioRxiv. 2023 Aug 17. Ma T, Xiong ES, Lardelli RM, Lykke-Andersen J. PMID: 37645788; PMCID: PMC10462049.
      View in: PubMed   Mentions:
    3. The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway. Mol Cell Biol. 2022 09 15; 42(9):e0005522. Carreño A, Lykke-Andersen J. PMID: 35920669; PMCID: PMC9476947.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Tailer: a pipeline for sequencing-based analysis of nonpolyadenylated RNA 3' end processing. RNA. 2022 05; 28(5):645-656. Nicholson-Shaw T, Lykke-Andersen J. PMID: 35181644; PMCID: PMC9014879.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Competition between maturation and degradation drives human snRNA 3' end quality control. Genes Dev. 2020 07 01; 34(13-14):989-1001. Lardelli RM, Lykke-Andersen J. PMID: 32499401; PMCID: PMC7328512.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Dev Cell. 2018 02 05; 44(3):392-402.e7. Chousal J, Cho K, Ramaiah M, Skarbrevik D, Mora-Castilla S, Stumpo DJ, Lykke-Andersen J, Laurent LC, Blackshear PJ, Wilkinson MF, Cook-Andersen H. PMID: 29408237; PMCID: PMC5805474.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    7. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464. Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çaglayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG. PMID: 28092684; PMCID: PMC5325768.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    8. A human microprotein that interacts with the mRNA decapping complex. Nat Chem Biol. 2017 02; 13(2):174-180. D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA. PMID: 27918561; PMCID: PMC5247292.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    9. Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Neuron. 2016 Nov 23; 92(4):780-795. Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, Lardelli R, Sundararaman B, Donohue JP, Javaherian A, Lykke-Andersen J, Finkbeiner S, Bennett CF, Ares M, Burge CB, Taylor JP, Rigo F, Yeo GW. PMID: 27773581; PMCID: PMC5123850.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    10. The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation. Mol Cell Biol. 2016 09 01; 36(17):2226-35. Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J. PMID: 27247266; PMCID: PMC4985932.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    11. Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. Nat Commun. 2016 08 11; 7:12434. Durand S, Franks TM, Lykke-Andersen J. PMID: 27511142; PMCID: PMC4987530.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    12. Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements. RNA. 2016 Mar; 22(3):373-82. Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J. PMID: 26763119; PMCID: PMC4748815.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    13. DDX6 Orchestrates Mammalian Progenitor Function through the mRNA Degradation and Translation Pathways. Mol Cell. 2015 Oct 01; 60(1):118-30. Wang Y, Arribas-Layton M, Chen Y, Lykke-Andersen J, Sen GL. PMID: 26412305; PMCID: PMC4592480.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    14. Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. Mol Cell. 2015 Aug 06; 59(3):413-25. Lee SR, Pratt GA, Martinez FJ, Yeo GW, Lykke-Andersen J. PMID: 26253027; PMCID: PMC4673969.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    15. Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity. Mol Cell Biol. 2015 Jun; 35(12):2144-53. Erickson SL, Corpuz EO, Maloy JP, Fillman C, Webb K, Bennett EJ, Lykke-Andersen J. PMID: 25870104; PMCID: PMC4438239.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    16. Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. Elife. 2015 Mar 27; 4:e03390. Hausburg MA, Doles JD, Clement SL, Cadwallader AB, Hall MN, Blackshear PJ, Lykke-Andersen J, Olwin BB. PMID: 25815583; PMCID: PMC4415119.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    17. Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay. RNA. 2015 May; 21(5):887-97. Toma KG, Rebbapragada I, Durand S, Lykke-Andersen J. PMID: 25805855; PMCID: PMC4408796.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    18. hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay. PLoS One. 2014; 9(6):e100992. Reznik B, Clement SL, Lykke-Andersen J. PMID: 24978456; PMCID: PMC4076271.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Protecting the proteome: Eukaryotic cotranslational quality control pathways. J Cell Biol. 2014 Feb 17; 204(4):467-76. Lykke-Andersen J, Bennett EJ. PMID: 24535822; PMCID: PMC3926952.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    20. Emerging roles for ribonucleoprotein modification and remodeling in controlling RNA fate. Trends Cell Biol. 2013 Oct; 23(10):504-10. Lee SR, Lykke-Andersen J. PMID: 23756094; PMCID: PMC3983964.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    21. Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells. Nat Struct Mol Biol. 2013 Jun; 20(6):702-9. Durand S, Lykke-Andersen J. PMID: 23665580.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    22. Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer. Cancer Treat Res. 2013; 158:153-80. Damgaard CK, Lykke-Andersen J. PMID: 24222358.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. Structural and functional control of the eukaryotic mRNA decapping machinery. Biochim Biophys Acta. 2013 Jun-Jul; 1829(6-7):580-9. Arribas-Layton M, Wu D, Lykke-Andersen J, Song H. PMID: 23287066; PMCID: PMC3660425.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    24. mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription. Mol Cell. 2012 May 11; 46(3):311-24. Brannan K, Kim H, Erickson B, Glover-Cutter K, Kim S, Fong N, Kiemele L, Hansen K, Davis R, Lykke-Andersen J, Bentley DL. PMID: 22483619; PMCID: PMC3806456.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansCells
    25. Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev. 2011 Oct 01; 25(19):2057-68. Damgaard CK, Lykke-Andersen J. PMID: 21979918; PMCID: PMC3197204.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    26. SnapShot: Nonsense-mediated mRNA decay. Cell. 2011 Apr 15; 145(2):324-324.e2. Durand S, Lykke-Andersen J. PMID: 21496649.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. Cytoplasmic mRNP granules at a glance. J Cell Sci. 2011 Feb 01; 124(Pt 3):293-7. Erickson SL, Lykke-Andersen J. PMID: 21242308; PMCID: PMC3021993.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    28. Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell. 2010 Dec 10; 143(6):938-50. Franks TM, Singh G, Lykke-Andersen J. PMID: 21145460; PMCID: PMC3357093.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    29. Regulated and quality-control mRNA turnover pathways in eukaryotes. Biochem Soc Trans. 2010 Dec; 38(6):1506-10. Reznik B, Lykke-Andersen J. PMID: 21118116.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment. Mol Cell Biol. 2011 Jan; 31(2):256-66. Clement SL, Scheckel C, Stoecklin G, Lykke-Andersen J. PMID: 21078877; PMCID: PMC3019984.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    31. How and where are nonsense mRNAs degraded in mammalian cells? RNA Biol. 2010 Jan-Feb; 7(1):28-32. Mühlemann O, Lykke-Andersen J. PMID: 20023408; PMCID: PMC4049745.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    32. Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol. 2009 Jun; 21(3):394-402. Rebbapragada I, Lykke-Andersen J. PMID: 19359157.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    33. The control of mRNA decapping and P-body formation. Mol Cell. 2008 Dec 05; 32(5):605-15. Franks TM, Lykke-Andersen J. PMID: 19061636; PMCID: PMC2630519.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    34. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol. 2008 Apr 29; 6(4):e111. Singh G, Rebbapragada I, Lykke-Andersen J. PMID: 18447585; PMCID: PMC2689706.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansCells
    35. A tethering approach to study proteins that activate mRNA turnover in human cells. Methods Mol Biol. 2008; 419:121-33. Clement SL, Lykke-Andersen J. PMID: 18369979.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    36. Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Mol Cell. 2007 Sep 07; 27(5):780-92. Singh G, Jakob S, Kleedehn MG, Lykke-Andersen J. PMID: 17803942.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    37. TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev. 2007 Mar 15; 21(6):719-35. Franks TM, Lykke-Andersen J. PMID: 17369404; PMCID: PMC1820945.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansCells
    38. An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Mol Cell Biol. 2007 Mar; 27(5):1686-95. Wagner E, Clement SL, Lykke-Andersen J. PMID: 17178830; PMCID: PMC1820451.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    39. No mercy for messages that mess with the ribosome. Nat Struct Mol Biol. 2006 Apr; 13(4):299-301. Clement SL, Lykke-Andersen J. PMID: 16715045.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    40. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell. 2005 Dec 22; 20(6):905-15. Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J. PMID: 16364915.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansCells
    41. Messenger RNA surveillance: neutralizing natural nonsense. Curr Biol. 2005 Jul 26; 15(14):R559-62. Weischenfeldt J, Lykke-Andersen J, Porse B. PMID: 16051166.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    42. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol. 2005 Jun 20; 169(6):871-84. Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P. PMID: 15967811; PMCID: PMC2171635.
      View in: PubMed   Mentions: 709     Fields:    Translation:HumansAnimalsCells
    43. RNA decapping inside and outside of processing bodies. Curr Opin Cell Biol. 2005 Jun; 17(3):326-31. Fillman C, Lykke-Andersen J. PMID: 15901504.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    44. Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev. 2005 Feb 01; 19(3):351-61. Lykke-Andersen J, Wagner E. PMID: 15687258; PMCID: PMC546513.
      View in: PubMed   Mentions: 260     Fields:    Translation:HumansCells
    45. Making structural sense of nonsense-mediated decay. Nat Struct Mol Biol. 2004 Apr; 11(4):305-6. Lykke-Andersen J. PMID: 15048104.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    46. Nuclear transit of human zipcode-binding protein IMP1. Biochem J. 2003 Dec 01; 376(Pt 2):383-91. Nielsen J, Adolph SK, Rajpert-De Meyts E, Lykke-Andersen J, Koch G, Christiansen J, Nielsen FC. PMID: 12921532; PMCID: PMC1223771.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    47. New insights into the formation of active nonsense-mediated decay complexes. Trends Biochem Sci. 2003 Sep; 28(9):464-6. Singh G, Lykke-Andersen J. PMID: 13678954.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    48. mRNA surveillance: the perfect persist. J Cell Sci. 2002 Aug 01; 115(Pt 15):3033-8. Wagner E, Lykke-Andersen J. PMID: 12118059.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    49. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science. 2001 Sep 07; 293(5536):1836-9. Lykke-Andersen J, Shu MD, Steitz JA. PMID: 11546874.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    50. mRNA quality control: Marking the message for life or death. Curr Biol. 2001 Feb 06; 11(3):R88-91. Lykke-Andersen J. PMID: 11231165.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    51. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell. 2000 Dec 22; 103(7):1121-31. Lykke-Andersen J, Shu MD, Steitz JA. PMID: 11163187.
      View in: PubMed   Mentions: 271     Fields:    Translation:HumansAnimalsCells
    52. H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. J Biol Chem. 2000 Sep 22; 275(38):29562-9. Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J. PMID: 10875929.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    53. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol. 1999 Feb; 19(2):1262-70. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC. PMID: 9891060; PMCID: PMC116055.
      View in: PubMed   Mentions: 285     Fields:    Translation:HumansAnimalsCells
    54. The C-terminal carboxy group of T7 RNA polymerase ensures efficient magnesium ion-dependent catalysis. Nucleic Acids Res. 1998 Dec 15; 26(24):5630-5. Lykke-Andersen J, Christiansen J. PMID: 9837993; PMCID: PMC148041.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    55. RNA-protein interactions of an archaeal homotetrameric splicing endoribonuclease with an exceptional evolutionary history. EMBO J. 1997 Oct 15; 16(20):6290-300. Lykke-Andersen J, Garrett RA. PMID: 9321408; PMCID: PMC1326313.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    56. Archaeal introns: splicing, intercellular mobility and evolution. Trends Biochem Sci. 1997 Sep; 22(9):326-31. Lykke-Andersen J, Aagaard C, Semionenkov M, Garrett RA. PMID: 9301331.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    57. Mapping metal ions at the catalytic centres of two intron-encoded endonucleases. EMBO J. 1997 Jun 02; 16(11):3272-81. Lykke-Andersen J, Garrett RA, Kjems J. PMID: 9214642; PMCID: PMC1169943.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    58. Protein footprinting approach to mapping DNA binding sites of two archaeal homing enzymes: evidence for a two-domain protein structure. Nucleic Acids Res. 1996 Oct 15; 24(20):3982-9. Lykke-Andersen J, Garrett RA, Kjems J. PMID: 8918801; PMCID: PMC146195.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    59. DNA substrate specificity and cleavage kinetics of an archaeal homing-type endonuclease from Pyrobaculum organotrophum. Nucleic Acids Res. 1994 Nov 11; 22(22):4583-90. Lykke-Andersen J, Thi-Ngoc HP, Garrett RA. PMID: 7984405; PMCID: PMC308504.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    60. Structural characteristics of the stable RNA introns of archaeal hyperthermophiles and their splicing junctions. J Mol Biol. 1994 Nov 11; 243(5):846-55. Lykke-Andersen J, Garrett RA. PMID: 7966305.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
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