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Sm complex assembly and 5' cap trimethylation promote selective processing of snRNAs by the 3' exonuclease TOE1. Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3):e2315259121.
Ma T, Xiong ES, Lardelli RM, Lykke-Andersen J. PMID: 38194449; PMCID: PMC10801842.
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PubMed Mentions: Fields:
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Assigning functionality to cysteines by base editing of cancer dependency genes. Nat Chem Biol. 2023 Nov; 19(11):1320-1330.
Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF. PMID: 37783940; PMCID: PMC10698195.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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The 3' exonuclease TOE1 selectively processes snRNAs through recognition of Sm complex assembly and 5' cap trimethylation. bioRxiv. 2023 Aug 17.
Ma T, Xiong ES, Lardelli RM, Lykke-Andersen J. PMID: 37645788; PMCID: PMC10462049.
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The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway. Mol Cell Biol. 2022 09 15; 42(9):e0005522.
Carreño A, Lykke-Andersen J. PMID: 35920669; PMCID: PMC9476947.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Tailer: a pipeline for sequencing-based analysis of nonpolyadenylated RNA 3' end processing. RNA. 2022 05; 28(5):645-656.
Nicholson-Shaw T, Lykke-Andersen J. PMID: 35181644; PMCID: PMC9014879.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Competition between maturation and degradation drives human snRNA 3' end quality control. Genes Dev. 2020 07 01; 34(13-14):989-1001.
Lardelli RM, Lykke-Andersen J. PMID: 32499401; PMCID: PMC7328512.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Dev Cell. 2018 02 05; 44(3):392-402.e7.
Chousal J, Cho K, Ramaiah M, Skarbrevik D, Mora-Castilla S, Stumpo DJ, Lykke-Andersen J, Laurent LC, Blackshear PJ, Wilkinson MF, Cook-Andersen H. PMID: 29408237; PMCID: PMC5805474.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464.
Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çaglayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG. PMID: 28092684; PMCID: PMC5325768.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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A human microprotein that interacts with the mRNA decapping complex. Nat Chem Biol. 2017 02; 13(2):174-180.
D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA. PMID: 27918561; PMCID: PMC5247292.
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PubMed Mentions:
132 Fields:
Translation:
HumansAnimalsCells
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Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Neuron. 2016 Nov 23; 92(4):780-795.
Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, Lardelli R, Sundararaman B, Donohue JP, Javaherian A, Lykke-Andersen J, Finkbeiner S, Bennett CF, Ares M, Burge CB, Taylor JP, Rigo F, Yeo GW. PMID: 27773581; PMCID: PMC5123850.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
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The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation. Mol Cell Biol. 2016 09 01; 36(17):2226-35.
Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J. PMID: 27247266; PMCID: PMC4985932.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. Nat Commun. 2016 08 11; 7:12434.
Durand S, Franks TM, Lykke-Andersen J. PMID: 27511142; PMCID: PMC4987530.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements. RNA. 2016 Mar; 22(3):373-82.
Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J. PMID: 26763119; PMCID: PMC4748815.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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DDX6 Orchestrates Mammalian Progenitor Function through the mRNA Degradation and Translation Pathways. Mol Cell. 2015 Oct 01; 60(1):118-30.
Wang Y, Arribas-Layton M, Chen Y, Lykke-Andersen J, Sen GL. PMID: 26412305; PMCID: PMC4592480.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. Mol Cell. 2015 Aug 06; 59(3):413-25.
Lee SR, Pratt GA, Martinez FJ, Yeo GW, Lykke-Andersen J. PMID: 26253027; PMCID: PMC4673969.
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PubMed Mentions:
68 Fields:
Translation:
HumansCells
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Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity. Mol Cell Biol. 2015 Jun; 35(12):2144-53.
Erickson SL, Corpuz EO, Maloy JP, Fillman C, Webb K, Bennett EJ, Lykke-Andersen J. PMID: 25870104; PMCID: PMC4438239.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. Elife. 2015 Mar 27; 4:e03390.
Hausburg MA, Doles JD, Clement SL, Cadwallader AB, Hall MN, Blackshear PJ, Lykke-Andersen J, Olwin BB. PMID: 25815583; PMCID: PMC4415119.
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PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay. RNA. 2015 May; 21(5):887-97.
Toma KG, Rebbapragada I, Durand S, Lykke-Andersen J. PMID: 25805855; PMCID: PMC4408796.
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PubMed Mentions:
53 Fields:
Translation:
HumansCells
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hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay. PLoS One. 2014; 9(6):e100992.
Reznik B, Clement SL, Lykke-Andersen J. PMID: 24978456; PMCID: PMC4076271.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Protecting the proteome: Eukaryotic cotranslational quality control pathways. J Cell Biol. 2014 Feb 17; 204(4):467-76.
Lykke-Andersen J, Bennett EJ. PMID: 24535822; PMCID: PMC3926952.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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Emerging roles for ribonucleoprotein modification and remodeling in controlling RNA fate. Trends Cell Biol. 2013 Oct; 23(10):504-10.
Lee SR, Lykke-Andersen J. PMID: 23756094; PMCID: PMC3983964.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells. Nat Struct Mol Biol. 2013 Jun; 20(6):702-9.
Durand S, Lykke-Andersen J. PMID: 23665580.
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PubMed Mentions:
53 Fields:
Translation:
HumansCells
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Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer. Cancer Treat Res. 2013; 158:153-80.
Damgaard CK, Lykke-Andersen J. PMID: 24222358.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Structural and functional control of the eukaryotic mRNA decapping machinery. Biochim Biophys Acta. 2013 Jun-Jul; 1829(6-7):580-9.
Arribas-Layton M, Wu D, Lykke-Andersen J, Song H. PMID: 23287066; PMCID: PMC3660425.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription. Mol Cell. 2012 May 11; 46(3):311-24.
Brannan K, Kim H, Erickson B, Glover-Cutter K, Kim S, Fong N, Kiemele L, Hansen K, Davis R, Lykke-Andersen J, Bentley DL. PMID: 22483619; PMCID: PMC3806456.
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PubMed Mentions:
131 Fields:
Translation:
HumansCells
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Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev. 2011 Oct 01; 25(19):2057-68.
Damgaard CK, Lykke-Andersen J. PMID: 21979918; PMCID: PMC3197204.
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PubMed Mentions:
132 Fields:
Translation:
HumansCells
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SnapShot: Nonsense-mediated mRNA decay. Cell. 2011 Apr 15; 145(2):324-324.e2.
Durand S, Lykke-Andersen J. PMID: 21496649.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Cytoplasmic mRNP granules at a glance. J Cell Sci. 2011 Feb 01; 124(Pt 3):293-7.
Erickson SL, Lykke-Andersen J. PMID: 21242308; PMCID: PMC3021993.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell. 2010 Dec 10; 143(6):938-50.
Franks TM, Singh G, Lykke-Andersen J. PMID: 21145460; PMCID: PMC3357093.
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PubMed Mentions:
139 Fields:
Translation:
HumansCells
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Regulated and quality-control mRNA turnover pathways in eukaryotes. Biochem Soc Trans. 2010 Dec; 38(6):1506-10.
Reznik B, Lykke-Andersen J. PMID: 21118116.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment. Mol Cell Biol. 2011 Jan; 31(2):256-66.
Clement SL, Scheckel C, Stoecklin G, Lykke-Andersen J. PMID: 21078877; PMCID: PMC3019984.
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PubMed Mentions:
107 Fields:
Translation:
HumansCells
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How and where are nonsense mRNAs degraded in mammalian cells? RNA Biol. 2010 Jan-Feb; 7(1):28-32.
Mühlemann O, Lykke-Andersen J. PMID: 20023408; PMCID: PMC4049745.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol. 2009 Jun; 21(3):394-402.
Rebbapragada I, Lykke-Andersen J. PMID: 19359157.
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PubMed Mentions:
145 Fields:
Translation:
HumansAnimalsCells
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The control of mRNA decapping and P-body formation. Mol Cell. 2008 Dec 05; 32(5):605-15.
Franks TM, Lykke-Andersen J. PMID: 19061636; PMCID: PMC2630519.
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PubMed Mentions:
210 Fields:
Translation:
HumansAnimalsCells
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A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol. 2008 Apr 29; 6(4):e111.
Singh G, Rebbapragada I, Lykke-Andersen J. PMID: 18447585; PMCID: PMC2689706.
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PubMed Mentions:
198 Fields:
Translation:
HumansCells
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A tethering approach to study proteins that activate mRNA turnover in human cells. Methods Mol Biol. 2008; 419:121-33.
Clement SL, Lykke-Andersen J. PMID: 18369979.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Mol Cell. 2007 Sep 07; 27(5):780-92.
Singh G, Jakob S, Kleedehn MG, Lykke-Andersen J. PMID: 17803942.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev. 2007 Mar 15; 21(6):719-35.
Franks TM, Lykke-Andersen J. PMID: 17369404; PMCID: PMC1820945.
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PubMed Mentions:
137 Fields:
Translation:
HumansCells
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An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Mol Cell Biol. 2007 Mar; 27(5):1686-95.
Wagner E, Clement SL, Lykke-Andersen J. PMID: 17178830; PMCID: PMC1820451.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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No mercy for messages that mess with the ribosome. Nat Struct Mol Biol. 2006 Apr; 13(4):299-301.
Clement SL, Lykke-Andersen J. PMID: 16715045.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell. 2005 Dec 22; 20(6):905-15.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J. PMID: 16364915.
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PubMed Mentions:
262 Fields:
Translation:
HumansCells
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Messenger RNA surveillance: neutralizing natural nonsense. Curr Biol. 2005 Jul 26; 15(14):R559-62.
Weischenfeldt J, Lykke-Andersen J, Porse B. PMID: 16051166.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol. 2005 Jun 20; 169(6):871-84.
Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P. PMID: 15967811; PMCID: PMC2171635.
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PubMed Mentions:
729 Fields:
Translation:
HumansAnimalsCells
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RNA decapping inside and outside of processing bodies. Curr Opin Cell Biol. 2005 Jun; 17(3):326-31.
Fillman C, Lykke-Andersen J. PMID: 15901504.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev. 2005 Feb 01; 19(3):351-61.
Lykke-Andersen J, Wagner E. PMID: 15687258; PMCID: PMC546513.
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PubMed Mentions:
261 Fields:
Translation:
HumansCells
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Making structural sense of nonsense-mediated decay. Nat Struct Mol Biol. 2004 Apr; 11(4):305-6.
Lykke-Andersen J. PMID: 15048104.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Nuclear transit of human zipcode-binding protein IMP1. Biochem J. 2003 Dec 01; 376(Pt 2):383-91.
Nielsen J, Adolph SK, Rajpert-De Meyts E, Lykke-Andersen J, Koch G, Christiansen J, Nielsen FC. PMID: 12921532; PMCID: PMC1223771.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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New insights into the formation of active nonsense-mediated decay complexes. Trends Biochem Sci. 2003 Sep; 28(9):464-6.
Singh G, Lykke-Andersen J. PMID: 13678954.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol. 2002 Dec; 22(23):8114-21.
Lykke-Andersen J. PMID: 12417715; PMCID: PMC134073.
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PubMed Mentions:
180 Fields:
Translation:
HumansCells
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mRNA surveillance: the perfect persist. J Cell Sci. 2002 Aug 01; 115(Pt 15):3033-8.
Wagner E, Lykke-Andersen J. PMID: 12118059.
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PubMed Mentions:
77 Fields:
Translation:
HumansAnimalsCells
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Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science. 2001 Sep 07; 293(5536):1836-9.
Lykke-Andersen J, Shu MD, Steitz JA. PMID: 11546874.
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PubMed Mentions:
170 Fields:
Translation:
HumansAnimalsCells
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mRNA quality control: Marking the message for life or death. Curr Biol. 2001 Feb 06; 11(3):R88-91.
Lykke-Andersen J. PMID: 11231165.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell. 2000 Dec 22; 103(7):1121-31.
Lykke-Andersen J, Shu MD, Steitz JA. PMID: 11163187.
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PubMed Mentions:
272 Fields:
Translation:
HumansAnimalsCells
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H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. J Biol Chem. 2000 Sep 22; 275(38):29562-9.
Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J. PMID: 10875929.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol. 1999 Feb; 19(2):1262-70.
Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC. PMID: 9891060; PMCID: PMC116055.
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PubMed Mentions:
293 Fields:
Translation:
HumansAnimalsCells
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The C-terminal carboxy group of T7 RNA polymerase ensures efficient magnesium ion-dependent catalysis. Nucleic Acids Res. 1998 Dec 15; 26(24):5630-5.
Lykke-Andersen J, Christiansen J. PMID: 9837993; PMCID: PMC148041.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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RNA-protein interactions of an archaeal homotetrameric splicing endoribonuclease with an exceptional evolutionary history. EMBO J. 1997 Oct 15; 16(20):6290-300.
Lykke-Andersen J, Garrett RA. PMID: 9321408; PMCID: PMC1326313.
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PubMed Mentions:
30 Fields:
Translation:
Cells
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Archaeal introns: splicing, intercellular mobility and evolution. Trends Biochem Sci. 1997 Sep; 22(9):326-31.
Lykke-Andersen J, Aagaard C, Semionenkov M, Garrett RA. PMID: 9301331.
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PubMed Mentions:
41 Fields:
Translation:
Cells
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Mapping metal ions at the catalytic centres of two intron-encoded endonucleases. EMBO J. 1997 Jun 02; 16(11):3272-81.
Lykke-Andersen J, Garrett RA, Kjems J. PMID: 9214642; PMCID: PMC1169943.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Protein footprinting approach to mapping DNA binding sites of two archaeal homing enzymes: evidence for a two-domain protein structure. Nucleic Acids Res. 1996 Oct 15; 24(20):3982-9.
Lykke-Andersen J, Garrett RA, Kjems J. PMID: 8918801; PMCID: PMC146195.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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DNA substrate specificity and cleavage kinetics of an archaeal homing-type endonuclease from Pyrobaculum organotrophum. Nucleic Acids Res. 1994 Nov 11; 22(22):4583-90.
Lykke-Andersen J, Thi-Ngoc HP, Garrett RA. PMID: 7984405; PMCID: PMC308504.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Structural characteristics of the stable RNA introns of archaeal hyperthermophiles and their splicing junctions. J Mol Biol. 1994 Nov 11; 243(5):846-55.
Lykke-Andersen J, Garrett RA. PMID: 7966305.
View in:
PubMed Mentions:
17 Fields:
Translation:
Cells