Kevin Corbett

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-5854-2388 Additional info
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    Collapse Biography 
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    Harvard Medical SchoolPostdoctoral2011Biological Chemistry & Molecular Pharmacology
    University of California, BerkeleyPh.D.2005Molecular Cell Biology
    University of VirginiaB.S.2000Chemistry

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    Our lab is focused on the molecular mechanisms of chromosome segregation in meiosis. We use biochemistry, X-ray crystallography, and genetics in S. cerevisiae to probe the structure, function, and interactions between proteins involved in meiotic chromosome pairing, crossover initiation and maturation, and chromosome segregation. A new focus involves the structure and function of the first identified bacterial HORMA domain proteins, a family of signaling proteins previously thought to exist only in eukaryotes.
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    Molecular mechanisms of the first-identified bacterial HORMA and Pch2-like proteins in a novel second-messenger signaling pathway
    NIH R21AI148814Jan 17, 2020 - Dec 31, 2021
    Role: Principal Investigator
    Expanding the CRISPR/Cas toolbox for RNA modulation
    NIH R01GM128464May 21, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Molecular mechanisms of chromosome organization and recombination control by the meiotic chromosome axis
    NIH R01GM104141Dec 10, 2012 - Jan 31, 2022
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores. J Cell Biol. 2024 Jul 01; 223(7). Houston J, Vissotsky C, Deep A, Hakozaki H, Crews E, Oegema K, Corbett KD, Lara-Gonzalez P, Kim T, Desai A. PMID: 38578284; PMCID: PMC10996584.
      View in: PubMed   Mentions:    Fields:    
    2. Viral Receptor-Binding Protein Evolves New Function through Mutations That Cause Trimer Instability and Functional Heterogeneity. Mol Biol Evol. 2024 Apr 02; 41(4). Strobel HM, Labador SD, Basu D, Sane M, Corbett KD, Meyer JR. PMID: 38586942; PMCID: PMC10999833.
      View in: PubMed   Mentions:
    3. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. Nucleic Acids Res. 2024 Mar 30. Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Malukhina K, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Bintu B, Yeo GW, Pogliano J, Corbett KD. PMID: 38554115.
      View in: PubMed   Mentions:    Fields:    
    4. An essential and highly selective protein import pathway encoded by nucleus-forming phage. bioRxiv. 2024 Mar 21. Morgan CJ, Enustun E, Armbruster EG, Birkholz EA, Prichard A, Forman T, Aindow A, Wannasrichan W, Peters S, Inlow K, Shepherd IL, Razavilar A, Chaikeeratisak V, Adler BA, Cress BF, Doudna JA, Pogliano K, Villa E, Corbett KD, Pogliano J. PMID: 38562762; PMCID: PMC10983916.
      View in: PubMed   Mentions:
    5. Phosphorylation regulates tau's phase separation behavior and interactions with chromatin. Commun Biol. 2024 Mar 01; 7(1):251. Abasi LS, Elathram N, Movva M, Deep A, Corbett KD, Debelouchina GT. PMID: 38429335; PMCID: PMC10907630.
      View in: PubMed   Mentions: Translation:HumansCells
    6. Loop extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex. bioRxiv. 2024 Feb 17. Pradhan B, Deep A, König J, Baaske MD, Corbett KD, Kim E. PMID: 38405785; PMCID: PMC10889018.
      View in: PubMed   Mentions:
    7. Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores. bioRxiv. 2024 Feb 11. Houston J, Vissotsky C, Deep A, Hakozaki H, Crews E, Oegema K, Corbett KD, Lara-Gonzalez P, Kim T, Desai A. PMID: 38370671; PMCID: PMC10871365.
      View in: PubMed   Mentions:
    8. Chromatin binding by HORMAD proteins regulates meiotic recombination initiation. EMBO J. 2024 Mar; 43(5):836-867. Milano CR, Ur SN, Gu Y, Zhang J, Allison R, Brown G, Neale MJ, Tromer EC, Corbett KD, Hochwagen A. PMID: 38332377; PMCID: PMC10907721.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Architecture and infection-sensing mechanism of the bacterial PARIS defense system. bioRxiv. 2024 Jan 02. Deep A, Liang Q, Enustun E, Pogliano J, Corbett KD. PMID: 38260510; PMCID: PMC10802264.
      View in: PubMed   Mentions:
    10. Phosphorylation regulates tau's phase separation behavior and interactions with chromatin. bioRxiv. 2023 Dec 23. Abasi LS, Elathram N, Movva M, Deep A, Corbett KD, Debelouchina GT. PMID: 38187700; PMCID: PMC10769318.
      View in: PubMed   Mentions:
    11. A mobile intron facilitates interference competition between co-infecting viruses. bioRxiv. 2023 Sep 30. Birkholz EA, Morgan CJ, Laughlin TG, Lau RK, Prichard A, Rangarajan S, Meza GN, Lee J, Armbruster EG, Suslov S, Pogliano K, Meyer JR, Villa E, Corbett KD, Pogliano J. PMID: 37808663; PMCID: PMC10557746.
      View in: PubMed   Mentions:
    12. Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems. bioRxiv. 2023 Sep 26. Chambers LR, Ye Q, Cai J, Gong M, Ledvina HE, Zhou H, Whiteley AT, Suhandynata RT, Corbett KD. PMID: 37808811; PMCID: PMC10557695.
      View in: PubMed   Mentions:
    13. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. bioRxiv. 2023 Sep 22. Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Yeo GW, Pogliano J, Corbett KD. PMID: 37790334; PMCID: PMC10542519.
      View in: PubMed   Mentions:
    14. Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection. bioRxiv. 2023 Sep 21. Armbruster EG, Lee J, Hutchings J, VanderWal AR, Enustun E, Adler BA, Aindow A, Deep A, Rodriguez ZK, Morgan CJ, Ghassemian M, Charles E, Cress BF, Savage DF, Doudna JA, Pogliano K, Corbett KD, Villa E, Pogliano J. PMID: 37781618; PMCID: PMC10541120.
      View in: PubMed   Mentions:
    15. Identification of the bacteriophage nucleus protein interaction network. Nat Struct Mol Biol. 2023 Nov; 30(11):1653-1662. Enustun E, Deep A, Gu Y, Nguyen KT, Chaikeeratisak V, Armbruster E, Ghassemian M, Villa E, Pogliano J, Corbett KD. PMID: 37667030; PMCID: PMC10643120.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains. bioRxiv. 2023 Aug 10. Gu Y, Li H, Deep A, Enustun E, Zhang D, Corbett KD. PMID: 37609250; PMCID: PMC10441436.
      View in: PubMed   Mentions:
    17. Identification of the bacteriophage nucleus protein interaction network. bioRxiv. 2023 May 18. Enustun E, Deep A, Gu Y, Nguyen KT, Chaikeeratisak V, Armbruster E, Ghassemian M, Villa E, Pogliano J, Corbett KD. PMID: 37292858; PMCID: PMC10245766.
      View in: PubMed   Mentions:
    18. BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses. Curr Biol. 2023 06 05; 33(11):2291-2299.e10. Houston J, Ohta M, Gómez-Cavazos JS, Deep A, Corbett KD, Oegema K, Lara-Gonzalez P, Kim T, Desai A. PMID: 37137308; PMCID: PMC10270731.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY. Cell Rep. 2023 05 30; 42(5):112432. Prichard A, Lee J, Laughlin TG, Lee A, Thomas KP, Sy AE, Spencer T, Asavavimol A, Cafferata A, Cameron M, Chiu N, Davydov D, Desai I, Diaz G, Guereca M, Hearst K, Huang L, Jacobs E, Johnson A, Kahn S, Koch R, Martinez A, Norquist M, Pau T, Prasad G, Saam K, Sandhu M, Sarabia AJ, Schumaker S, Sonin A, Uyeno A, Zhao A, Corbett KD, Pogliano K, Meyer J, Grose JH, Villa E, Dutton R, Pogliano J. PMID: 37120812; PMCID: PMC10299810.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    20. The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans. PLoS Genet. 2023 04; 19(4):e1010708. Russo AE, Giacopazzi S, Deshong A, Menon M, Ortiz V, Ego KM, Corbett KD, Bhalla N. PMID: 37058535; PMCID: PMC10132761.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    21. Author Correction: An E1-E2 fusion protein primes antiviral immune signalling in bacteria. Nature. 2023 Mar; 615(7954):E25. Ledvina HE, Ye Q, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD, Whiteley AT. PMID: 36914867.
      View in: PubMed   Mentions:    Fields:    
    22. Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY. bioRxiv. 2023 Feb 25. Prichard A, Lee J, Laughlin TG, Lee A, Thomas KP, Sy A, Spencer T, Asavavimol A, Cafferata A, Cameron M, Chiu N, Davydov D, Desai I, Diaz G, Guereca M, Hearst K, Huang L, Jacobs E, Johnson A, Kahn S, Koch R, Martinez A, Norquist M, Pau T, Prasad G, Saam K, Sandhu M, Sarabia AJ, Schumaker S, Sonin A, Uyeno A, Zhao A, Corbett K, Pogliano K, Meyer J, Grose JH, Villa E, Dutton R, Pogliano J. PMID: 36865095; PMCID: PMC9980170.
      View in: PubMed   Mentions:
    23. An E1-E2 fusion protein primes antiviral immune signalling in bacteria. Nature. 2023 04; 616(7956):319-325. Ledvina HE, Ye Q, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD, Whiteley AT. PMID: 36755092; PMCID: PMC10292035.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    24. The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA. Mol Cell. 2022 11 03; 82(21):4145-4159.e7. Deep A, Gu Y, Gao YQ, Ego KM, Herzik MA, Zhou H, Corbett KD. PMID: 36206765; PMCID: PMC9637719.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    25. A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage. EMBO J. 2022 11 17; 41(22):e111540. Lau RK, Enustun E, Gu Y, Nguyen JV, Corbett KD. PMID: 36156805; PMCID: PMC9670203.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    26. A cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E. coli. Cell Rep. 2022 08 16; 40(7):111179. Birkholz EA, Laughlin TG, Armbruster E, Suslov S, Lee J, Wittmann J, Corbett KD, Villa E, Pogliano J. PMID: 35977483; PMCID: PMC9891218.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    27. Architecture and self-assembly of the jumbo bacteriophage nuclear shell. Nature. 2022 08; 608(7922):429-435. Laughlin TG, Deep A, Prichard AM, Seitz C, Gu Y, Enustun E, Suslov S, Khanna K, Birkholz EA, Armbruster E, McCammon JA, Amaro RE, Pogliano J, Corbett KD, Villa E. PMID: 35922510; PMCID: PMC9365700.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    28. Structure and activity of a bacterial defense-associated 3'-5' exonuclease. Protein Sci. 2022 07; 31(7):e4374. Liang Q, Richey ST, Ur SN, Ye Q, Lau RK, Corbett KD. PMID: 35762727; PMCID: PMC9214754.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. Electron counting takes microED to the next level. Nat Methods. 2022 06; 19(6):652-653. Corbett KD, Herzik MA. PMID: 35637309.
      View in: PubMed   Mentions:    Fields:    
    30. Control of bacterial immune signaling by a WYL domain transcription factor. Nucleic Acids Res. 2022 05 20; 50(9):5239-5250. Blankenchip CL, Nguyen JV, Lau RK, Ye Q, Gu Y, Corbett KD. PMID: 35536256; PMCID: PMC9122588.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    31. Two pathways drive meiotic chromosome axis assembly in Saccharomyces cerevisiae. Nucleic Acids Res. 2022 05 06; 50(8):4545-4556. Heldrich J, Milano CR, Markowitz TE, Ur SN, Vale-Silva LA, Corbett KD, Hochwagen A. PMID: 35412621; PMCID: PMC9071447.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Evolutionary Dynamics and Molecular Mechanisms of HORMA Domain Protein Signaling. Annu Rev Biochem. 2022 06 21; 91:541-569. Gu Y, Desai A, Corbett KD. PMID: 35041460.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Architecture and Dynamics of Meiotic Chromosomes. Annu Rev Genet. 2021 11 23; 55:497-526. Ur SN, Corbett KD. PMID: 34530636.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    34. Structural Basis for SARS-CoV-2 Nucleocapsid Protein Recognition by Single-Domain Antibodies. Front Immunol. 2021; 12:719037. Ye Q, Lu S, Corbett KD. PMID: 34381460; PMCID: PMC8351461.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    35. Responses to 10 common criticisms of anti-racism action in STEMM. PLoS Comput Biol. 2021 07; 17(7):e1009141. Gosztyla ML, Kwong L, Murray NA, Williams CE, Behnke N, Curry P, Corbett KD, DSouza KN, Gala de Pablo J, Gicobi J, Javidnia M, Lotay N, Prescott SM, Quinn JP, Rivera ZMG, Smith MA, Tang KTY, Venkat A, Yamoah MA. PMID: 34264941; PMCID: PMC8282043.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Structural basis for SARS-CoV-2 Nucleocapsid protein recognition by single-domain antibodies. bioRxiv. 2021 Jun 01. Ye Q, Lu S, Corbett KD. PMID: 34100017; PMCID: PMC8183014.
      View in: PubMed   Mentions:
    37. A new phase in meiotic cell division. Nature. 2021 04; 592(7852):32-33. Corbett KD. PMID: 33731900.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    38. The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nat Commun. 2021 01 21; 12(1):502. Lu S, Ye Q, Singh D, Cao Y, Diedrich JK, Yates JR, Villa E, Cleveland DW, Corbett KD. PMID: 33479198; PMCID: PMC7820290.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansCells
    39. A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores. Science. 2021 01 01; 371(6524):64-67. Lara-Gonzalez P, Kim T, Oegema K, Corbett K, Desai A. PMID: 33384372; PMCID: PMC8191211.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    40. Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans. PLoS Genet. 2020 11; 16(11):e1008968. Sato-Carlton A, Nakamura-Tabuchi C, Li X, Boog H, Lehmer MK, Rosenberg SC, Barroso C, Martinez-Perez E, Corbett KD, Carlton PM. PMID: 33175901; PMCID: PMC7717579.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. p31comet and TRIP13 recycle Rev7 to regulate DNA repair. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):27761-27763. Corbett KD. PMID: 33122436; PMCID: PMC7668161.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    42. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell. 2020 11 12; 183(4):1043-1057.e15. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32970989; PMCID: PMC7489987.
      View in: PubMed   Mentions: 579     Fields:    Translation:HumansCellsPHPublic Health
    43. Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein. Protein Sci. 2020 09; 29(9):1890-1901. Ye Q, West AMV, Silletti S, Corbett KD. PMID: 32654247; PMCID: PMC7405475.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    44. The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. bioRxiv. 2020 Jul 31. Lu S, Ye Q, Singh D, Villa E, Cleveland DW, Corbett KD. PMID: 32766587; PMCID: PMC7402048.
      View in: PubMed   Mentions:
    45. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. bioRxiv. 2020 Jul 14. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32699853; PMCID: PMC7373134.
      View in: PubMed   Mentions: 1  
    46. The odds and implications of coinheritance of hemophilia A and B. Res Pract Thromb Haemost. 2020 Jul; 4(5):931-935. Karch C, Masser-Frye D, Limjoco J, Ryan SE, Fletcher SN, Corbett KD, Johnsen JM, Thornburg CD. PMID: 32685904; PMCID: PMC7354394.
      View in: PubMed   Mentions: 2  
    47. Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein. bioRxiv. 2020 Jun 08. Ye Q, West AMV, Silletti S, Corbett KD. PMID: 32511359; PMCID: PMC7263487.
      View in: PubMed   Mentions:
    48. Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein. J Biol Chem. 2020 02 28; 295(9):2804-2821. Sandoval DR, Gomez Toledo A, Painter CD, Tota EM, Sheikh MO, West AMV, Frank MM, Wells L, Xu D, Bicknell R, Corbett KD, Esko JD. PMID: 31964714; PMCID: PMC7049958.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    49. HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):709-722.e7. Ye Q, Lau RK, Mathews IT, Birkholz EA, Watrous JD, Azimi CS, Pogliano J, Jain M, Corbett KD. PMID: 31932165; PMCID: PMC7036143.
      View in: PubMed   Mentions: 62     Fields:    Translation:Cells
    50. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6. Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. PMID: 31932164; PMCID: PMC7065454.
      View in: PubMed   Mentions: 73     Fields:    Translation:Cells
    51. Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18423-18428. Xu H, Tong Z, Ye Q, Sun T, Hong Z, Zhang L, Bortnick A, Cho S, Beuzer P, Axelrod J, Hu Q, Wang M, Evans SM, Murre C, Lu LF, Sun S, Corbett KD, Cang H. PMID: 31444302; PMCID: PMC6744910.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    52. The molecular basis of monopolin recruitment to the kinetochore. Chromosoma. 2019 09; 128(3):331-354. Plowman R, Singh N, Tromer EC, Payan A, Duro E, Spanos C, Rappsilber J, Snel B, Kops GJPL, Corbett KD, Marston AL. PMID: 31037469; PMCID: PMC6823300.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    53. The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding. Nucleic Acids Res. 2019 03 18; 47(5):2365-2376. Arora K, Corbett KD. PMID: 30566683; PMCID: PMC6411835.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    54. Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase. Nat Struct Mol Biol. 2019 03; 26(3):164-174. Patel L, Kang R, Rosenberg SC, Qiu Y, Raviram R, Chee S, Hu R, Ren B, Cole F, Corbett KD. PMID: 30778236; PMCID: PMC6403010.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    55. A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. Elife. 2019 01 18; 8. West AM, Rosenberg SC, Ur SN, Lehmer MK, Ye Q, Hagemann G, Caballero I, Usón I, MacQueen AJ, Herzog F, Corbett KD. PMID: 30657449; PMCID: PMC6349405.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    56. The budding-yeast RWD protein Csm1 scaffolds diverse protein complexes through a conserved structural mechanism. Protein Sci. 2018 12; 27(12):2094-2100. Singh N, Corbett KD. PMID: 30252178; PMCID: PMC6237700.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    57. TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC. Nat Commun. 2018 10 19; 9(1):4354. Kim DH, Han JS, Ly P, Ye Q, McMahon MA, Myung K, Corbett KD, Cleveland DW. PMID: 30341343; PMCID: PMC6195577.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    58. Author Correction: Blocking Zika virus vertical transmission. Sci Rep. 2018 Jun 05; 8(1):8794. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. PMID: 29867187; PMCID: PMC5986756.
      View in: PubMed   Mentions: 3     Fields:    
    59. Blocking Zika virus vertical transmission. Sci Rep. 2018 01 19; 8(1):1218. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. PMID: 29352135; PMCID: PMC5775359.
      View in: PubMed   Mentions: 24     Fields:    
    60. Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. Nucleic Acids Res. 2018 01 09; 46(1):279-292. West AMV, Komives EA, Corbett KD. PMID: 29186573; PMCID: PMC5758881.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    61. Identification of H3K4me1-associated proteins at mammalian enhancers. Nat Genet. 2018 01; 50(1):73-82. Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B. PMID: 29255264; PMCID: PMC6007000.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    62. Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9. Cell. 2017 Aug 24; 170(5):899-912.e10. Batra R, Nelles DA, Pirie E, Blue SM, Marina RJ, Wang H, Chaim IA, Thomas JD, Zhang N, Nguyen V, Aigner S, Markmiller S, Xia G, Corbett KD, Swanson MS, Yeo GW. PMID: 28803727; PMCID: PMC5873302.
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    63. The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. EMBO J. 2017 08 15; 36(16):2419-2434. Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A, Cleveland DW, Corbett KD. PMID: 28659378; PMCID: PMC5556265.
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    64. Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex. Dev Cell. 2017 05 22; 41(4):424-437.e4. Cheerambathur DK, Prevo B, Hattersley N, Lewellyn L, Corbett KD, Oegema K, Desai A. PMID: 28535376; PMCID: PMC5572820.
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    65. Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity. Genes Dev. 2017 04 15; 31(8):802-815. Liang J, Singh N, Carlson CR, Albuquerque CP, Corbett KD, Zhou H. PMID: 28487408; PMCID: PMC5435892.
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    66. Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing. Prog Mol Subcell Biol. 2017; 56:429-455. Corbett KD. PMID: 28840248.
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    67. Molecular Architecture of the Yeast Monopolin Complex. Cell Rep. 2016 10 11; 17(3):929. Corbett KD, Harrison SC. PMID: 27732865.
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    68. Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. EMBO J. 2016 10 04; 35(19):2139-2151. Ye Q, Ur SN, Su TY, Corbett KD. PMID: 27491543; PMCID: PMC5048352.
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    69. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. PMID: 26947396; PMCID: PMC4786681.
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    70. A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. PLoS One. 2015; 10(12):e0143810. Albuquerque CP, Yeung E, Ma S, Fu T, Corbett KD, Zhou H. PMID: 26633173; PMCID: PMC4669148.
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    71. The multifaceted roles of the HORMA domain in cellular signaling. J Cell Biol. 2015 Nov 23; 211(4):745-55. Rosenberg SC, Corbett KD. PMID: 26598612; PMCID: PMC4657174.
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    72. Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. Elife. 2015 Jul 24; 4. Nithianantham S, Le S, Seto E, Jia W, Leary J, Corbett KD, Moore JK, Al-Bassam J. PMID: 26208336; PMCID: PMC4574351.
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    73. TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. Elife. 2015 Apr 28; 4. Ye Q, Rosenberg SC, Moeller A, Speir JA, Su TY, Corbett KD. PMID: 25918846; PMCID: PMC4439613.
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    74. The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins. Dev Cell. 2014 Nov 24; 31(4):487-502. Kim Y, Rosenberg SC, Kugel CL, Kostow N, Rog O, Davydov V, Su TY, Dernburg AF, Corbett KD. PMID: 25446517; PMCID: PMC4254552.
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    75. Sister kinetochores are mechanically fused during meiosis I in yeast. Science. 2014 Oct 10; 346(6206):248-51. Sarangapani KK, Duro E, Deng Y, Alves Fde L, Ye Q, Opoku KN, Ceto S, Rappsilber J, Corbett KD, Biggins S, Marston AL, Asbury CL. PMID: 25213378; PMCID: PMC4226495.
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    76. A new piece in the kinetochore jigsaw puzzle. J Cell Biol. 2014 Aug 18; 206(4):457-9. Corbett KD, Desai A. PMID: 25135931; PMCID: PMC4137055.
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    77. Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits. Mol Biol Cell. 2013 Sep; 24(17):2727-38. Bhandari D, Zhang J, Menon S, Lord C, Chen S, Helm JR, Thorsen K, Corbett KD, Hay JC, Ferro-Novick S. PMID: 23864707; PMCID: PMC3756924.
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    78. Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. 2013 Jul 19; 8(7):1611-20. Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko JD. PMID: 23679870; PMCID: PMC3806902.
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    79. α-Tubulin acetylation from the inside out. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19515-6. Al-Bassam J, Corbett KD. PMID: 23150594; PMCID: PMC3511746.
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    80. Molecular architecture of the yeast monopolin complex. Cell Rep. 2012 Jun 28; 1(6):583-9. Corbett KD, Harrison SC. PMID: 22813733; PMCID: PMC3494995.
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    81. Structure, assembly and reading of centromeric chromatin. Curr Opin Genet Dev. 2012 Apr; 22(2):139-47. Maddox PS, Corbett KD, Desai A. PMID: 22178421; PMCID: PMC3319190.
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    82. Molecular structures and interactions in the yeast kinetochore. Cold Spring Harb Symp Quant Biol. 2010; 75:395-401. Cho US, Corbett KD, Al-Bassam J, Bellizzi JJ, De Wulf P, Espelin CW, Miranda JJ, Simons K, Wei RR, Sorger PK, Harrison SC. PMID: 21467141; PMCID: PMC3207249.
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    83. Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. Proteins. 2010 Oct; 78(13):2738-44. Corbett KD, Berger JM. PMID: 20635416; PMCID: PMC2927708.
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    84. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010 Aug 20; 142(4):556-67. Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC. PMID: 20723757; PMCID: PMC2955198.
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    85. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010 Apr; 17(4):438-44. Abraham J, Corbett KD, Farzan M, Choe H, Harrison SC. PMID: 20208545; PMCID: PMC2920743.
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    86. How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. J Mol Biol. 2009 Feb 06; 385(5):1397-408. Stuchinskaya T, Mitchenall LA, Schoeffler AJ, Corbett KD, Berger JM, Bates AD, Maxwell A. PMID: 19094994; PMCID: PMC4343537.
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    87. Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI. Nat Struct Mol Biol. 2007 Jul; 14(7):611-9. Corbett KD, Benedetti P, Berger JM. PMID: 17603498.
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    88. Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci. 2007 Apr; 16(4):695-703. Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM. PMID: 17384234; PMCID: PMC2203349.
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    89. Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol. Nucleic Acids Res. 2006; 34(15):4269-77. Corbett KD, Berger JM. PMID: 16920739; PMCID: PMC1616964.
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    90. Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem. 2006 Sep 08; 281(36):26745-53. Reynolds KA, Thomson JM, Corbett KD, Bethel CR, Berger JM, Kirsch JF, Bonomo RA, Handel TM. PMID: 16809340.
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    91. The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol. 2005 Aug 19; 351(3):545-61. Corbett KD, Schoeffler AJ, Thomsen ND, Berger JM. PMID: 16023670.
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    92. Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI. Structure. 2005 Jun; 13(6):873-82. Corbett KD, Berger JM. PMID: 15939019.
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    93. Developing promiscuous glycosidases for glycoside synthesis: residues W433 and E432 in Sulfolobus solfataricus beta-glycosidase are important glucoside- and galactoside-specificity determinants. Chembiochem. 2005 May; 6(5):866-75. Hancock SM, Corbett K, Fordham-Skelton AP, Gatehouse JA, Davis BG. PMID: 15846595.
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    94. Narrowing substrate specificity in a directly evolved enzyme: the A293D mutant of aspartate aminotransferase. Biochemistry. 2004 Oct 12; 43(40):12780-7. Chow MA, McElroy KE, Corbett KD, Berger JM, Kirsch JF. PMID: 15461450.
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    95. The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7293-8. Corbett KD, Shultzaberger RK, Berger JM. PMID: 15123801; PMCID: PMC409912.
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    96. Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct. 2004; 33:95-118. Corbett KD, Berger JM. PMID: 15139806.
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    97. Emerging roles for plant topoisomerase VI. Chem Biol. 2003 Feb; 10(2):107-11. Corbett KD, Berger JM. PMID: 12618182.
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    98. Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution. EMBO J. 2003 Jan 02; 22(1):151-63. Corbett KD, Berger JM. PMID: 12505993; PMCID: PMC140052.
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    99. Tailoring the substrate specificity of the beta-glycosidase from the thermophilic archaeon Sulfolobus solfataricus. FEBS Lett. 2001 Dec 14; 509(3):355-60. Corbett K, Fordham-Skelton AP, Gatehouse JA, Davis BG. PMID: 11749955.
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    100. The many faces of Ras: recognition of small GTP-binding proteins. Trends Biochem Sci. 2001 Dec; 26(12):710-6. Corbett KD, Alber T. PMID: 11738594.
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    101. Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences. Clin Pharmacol Ther. 1998 Sep; 64(3):237-47. Greenblatt DJ, Wright CE, von Moltke LL, Harmatz JS, Ehrenberg BL, Harrel LM, Corbett K, Counihan M, Tobias S, Shader RI. PMID: 9757147.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    102. Metabolism of 5-chloro-2-cyclohexyl-1-oxo-6-sulphamoyl isoindoline, clorexolone (M and B 8430). Nature. 1965 Oct 16; 208(5007):286-7. Corbett K, Edwards SA, Lee GE, Threlfall TL. PMID: 5882456.
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