Dong Wang

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Peking University B.S.1998Dept. of Chemistry
    Massachusetts Institute of TechnologyPh. D.2004Dept. of Chemistry
    Stanford University Postdoc2009School of Medicine, Dept. of Structural Biology
    Collapse Awards and Honors
    MIT2002  - 2003Anna Fuller Fund Graduate Fellowship Award
    Leukemia & Lymphoma Society 2007  - 2008Special Fellow Award
    NIH2008  - 2012NIH Pathway to Independence Award
    The Sidney Kimmel Foundation for Cancer Research 2012  - 2014Kimmel Scholar Award
    CAPA2015OKeanos-CAPA Young Investigator Award at the Chemical and Biology Interface

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanisms for DNA Damage Processing by Transcription Machinery
    NIH R01GM102362Jan 1, 2013 - Jan 31, 2022
    Role: Principal Investigator
    Structural Basis of Transcriptional Mutagenesis and Arrest of RNA Polymerase II
    NIH R00GM085136Jul 1, 2008 - Dec 31, 2012
    Role: Principal Investigator
    Structural Basis of Transcriptional Mutagenesis and Arrest of RNA Polymerase II
    NIH K99GM085136Jul 1, 2008 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes. PLoS Comput Biol. 2015 Jul; 11(7):e1004354. Zhang L, Silva DA, Pardo-Avila F, Wang D, Huang X. PMID: 26134169; PMCID: PMC4489626.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    2. Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 2015 Jul 30; 523(7562):621-5. Wang L, Zhou Y, Xu L, Xiao R, Lu X, Chen L, Chong J, Li H, He C, Fu XD, Wang D. PMID: 26123024; PMCID: PMC4521995.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    3. Impact of template backbone heterogeneity on RNA polymerase II transcription. Nucleic Acids Res. 2015 Feb 27; 43(4):2232-41. Xu L, Wang W, Zhang L, Chong J, Huang X, Wang D. PMID: 25662224; PMCID: PMC4344504.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    4. Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):E410-9. Walmacq C, Wang L, Chong J, Scibelli K, Lubkowska L, Gnatt A, Brooks PJ, Wang D, Kashlev M. PMID: 25605892; PMCID: PMC4321233.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    5. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18566-71. Wang L, Limbo O, Fei J, Chen L, Kim B, Luo J, Chong J, Conaway RC, Conaway JW, Ranish JA, Kadonaga JT, Russell P, Wang D. PMID: 25512493; PMCID: PMC4284531.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    6. Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation. Angew Chem Int Ed Engl. 2014 Oct 13; 53(42):11223-7. Xu L, Chen YC, Chong J, Fin A, McCoy LS, Xu J, Zhang C, Wang D. PMID: 25159856; PMCID: PMC4227401.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    7. Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3269-76. Xu L, Zhang L, Chong J, Xu J, Huang X, Wang D. PMID: 25074911; PMCID: PMC4136571.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    8. Molecular dynamics simulation study of conformational changes of transcription factor TFIIS during RNA polymerase II transcriptional arrest and reactivation. PLoS One. 2014; 9(5):e97975. Eun C, Ortiz-Sánchez JM, Da L, Wang D, McCammon JA. PMID: 24842057; PMCID: PMC4026522.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    9. Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis. DNA Repair (Amst). 2014 Jul; 19:71-83. Xu L, Da L, Plouffe SW, Chong J, Kool E, Wang D. PMID: 24767259; PMCID: PMC4051827.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    10. Millisecond dynamics of RNA polymerase II translocation at atomic resolution. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7665-70. Silva DA, Weiss DR, Pardo Avila F, Da LT, Levitt M, Wang D, Huang X. PMID: 24753580; PMCID: PMC4040580.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    11. Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues. Nucleic Acids Res. 2014 May; 42(9):5863-70. Xu L, Butler KV, Chong J, Wengel J, Kool ET, Wang D. PMID: 24692664; PMCID: PMC4027217.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    12. A Chemical Probe Targets DNA 5-Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. Chem Sci. 2014 Feb 01; 5(2):567-574. Xu L, Chen YC, Nakajima S, Chong J, Wang L, Lan L, Zhang C, Wang D. PMID: 24883182; PMCID: PMC4038700.
      View in: PubMed   Mentions: 6  
    13. A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids. Angew Chem Int Ed Engl. 2013 Nov 18; 52(47):12341-5. Xu L, Plouffe SW, Chong J, Wengel J, Wang D. PMID: 24167045; PMCID: PMC3866818.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    14. Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis. J Am Chem Soc. 2013 Sep 04; 135(35):13054-61. Kellinger MW, Park GY, Chong J, Lippard SJ, Wang D. PMID: 23927577; PMCID: PMC3791135.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    15. Understanding the Molecular Basis of RNA Polymerase II Transcription. Isr J Chem. 2013 Jun; 53(6-7). Zhang S, Wang D. PMID: 24403644; PMCID: PMC3881536.
      View in: PubMed   Mentions: 8  
    16. 5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. Nat Struct Mol Biol. 2012 Aug; 19(8):831-3. Kellinger MW, Song CX, Chong J, Lu XY, He C, Wang D. PMID: 22820989; PMCID: PMC3414690.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    17. Dissecting chemical interactions governing RNA polymerase II transcriptional fidelity. J Am Chem Soc. 2012 May 16; 134(19):8231-40. Kellinger MW, Ulrich S, Chong J, Kool ET, Wang D. PMID: 22509745; PMCID: PMC3367139.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    18. X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9584-9. Wang D, Zhu G, Huang X, Lippard SJ. PMID: 20448203; PMCID: PMC2906855.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    19. Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism. Science. 2010 Jan 08; 327(5962):206-9. Liu X, Bushnell DA, Wang D, Calero G, Kornberg RD. PMID: 19965383; PMCID: PMC2813267.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    20. Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science. 2009 May 29; 324(5931):1203-6. Wang D, Bushnell DA, Huang X, Westover KD, Levitt M, Kornberg RD. PMID: 19478184; PMCID: PMC2718261.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    21. Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis. Cell. 2006 Dec 01; 127(5):941-54. Wang D, Bushnell DA, Westover KD, Kaplan CD, Kornberg RD. PMID: 17129781; PMCID: PMC1876690.
      View in: PubMed   Mentions: 255     Fields:    Translation:AnimalsCells
    22. Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12311-6. Danford AJ, Wang D, Wang Q, Tullius TD, Lippard SJ. PMID: 16116097; PMCID: PMC1194956.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    23. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Mol Cell. 2005 Apr 15; 18(2):237-43. Takagi Y, Masuda CA, Chang WH, Komori H, Wang D, Hunter T, Joazeiro CA, Kornberg RD. PMID: 15837426.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    24. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov. 2005 Apr; 4(4):307-20. Wang D, Lippard SJ. PMID: 15789122.
      View in: PubMed   Mentions: 1033     Fields:    Translation:HumansAnimalsCells
    25. Cisplatin-induced post-translational modification of histones H3 and H4. J Biol Chem. 2004 May 14; 279(20):20622-5. Wang D, Lippard SJ. PMID: 15010460.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    26. Nucleotide excision repair from site-specifically platinum-modified nucleosomes. Biochemistry. 2003 Jun 10; 42(22):6747-53. Wang D, Hara R, Singh G, Sancar A, Lippard SJ. PMID: 12779329.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    27. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4239-44. Lee KB, Wang D, Lippard SJ, Sharp PA. PMID: 11904382; PMCID: PMC123632.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
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