Dong Wang

Title(s)Associate Professor, School of Pharmacy and Pharmaceutical Science
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    Peking University B.S.1998Dept. of Chemistry
    Massachusetts Institute of TechnologyPh. D.2004Dept. of Chemistry
    Stanford University Postdoc2009School of Medicine, Dept. of Structural Biology
    Collapse Awards and Honors
    MIT2002  - 2003Anna Fuller Fund Graduate Fellowship Award
    Leukemia & Lymphoma Society 2007  - 2008Special Fellow Award
    NIH2008  - 2012NIH Pathway to Independence Award
    The Sidney Kimmel Foundation for Cancer Research 2012  - 2014Kimmel Scholar Award
    CAPA2015OKeanos-CAPA Young Investigator Award at the Chemical and Biology Interface

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanisms for DNA Damage Processing by Transcription Machinery
    NIH/NIGMS R01GM102362Jan 1, 2013 - Jan 31, 2022
    Role: Principal Investigator
    Structural Basis of Transcriptional Mutagenesis and Arrest of RNA Polymerase II
    NIH/NIGMS R00GM085136Jul 1, 2008 - Dec 31, 2012
    Role: Principal Investigator
    Structural Basis of Transcriptional Mutagenesis and Arrest of RNA Polymerase II
    NIH/NIGMS K99GM085136Jul 1, 2008 - Jun 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zhang L, Silva DA, Pardo-Avila F, Wang D, Huang X. Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes. PLoS Comput Biol. 2015 Jul; 11(7):e1004354. PMID: 26134169; PMCID: PMC4489626.
    2. Wang L, Zhou Y, Xu L, Xiao R, Lu X, Chen L, Chong J, Li H, He C, Fu XD, Wang D. Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 2015 Jul 30; 523(7562):621-5. PMID: 26123024.
      View in: PubMed
    3. Xu L, Wang W, Zhang L, Chong J, Huang X, Wang D. Impact of template backbone heterogeneity on RNA polymerase II transcription. Nucleic Acids Res. 2015 Feb 27; 43(4):2232-41. PMID: 25662224; PMCID: PMC4344504.
    4. Walmacq C, Wang L, Chong J, Scibelli K, Lubkowska L, Gnatt A, Brooks PJ, Wang D, Kashlev M. Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):E410-9. PMID: 25605892; PMCID: PMC4321233.
    5. Wang L, Limbo O, Fei J, Chen L, Kim B, Luo J, Chong J, Conaway RC, Conaway JW, Ranish JA, Kadonaga JT, Russell P, Wang D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18566-71. PMID: 25512493; PMCID: PMC4284531.
    6. Xu L, Chen YC, Chong J, Fin A, McCoy LS, Xu J, Zhang C, Wang D. Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation. Angew Chem Int Ed Engl. 2014 Oct 13; 53(42):11223-7. PMID: 25159856; PMCID: PMC4227401.
    7. Xu L, Zhang L, Chong J, Xu J, Huang X, Wang D. Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3269-76. PMID: 25074911; PMCID: PMC4136571.
    8. Eun C, Ortiz-Sánchez JM, Da L, Wang D, McCammon JA. Molecular dynamics simulation study of conformational changes of transcription factor TFIIS during RNA polymerase II transcriptional arrest and reactivation. PLoS One. 2014; 9(5):e97975. PMID: 24842057; PMCID: PMC4026522.
    9. Xu L, Da L, Plouffe SW, Chong J, Kool E, Wang D. Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis. DNA Repair (Amst). 2014 Jul; 19:71-83. PMID: 24767259; PMCID: PMC4051827.
    10. Silva DA, Weiss DR, Pardo Avila F, Da LT, Levitt M, Wang D, Huang X. Millisecond dynamics of RNA polymerase II translocation at atomic resolution. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7665-70. PMID: 24753580; PMCID: PMC4040580.
    11. Xu L, Butler KV, Chong J, Wengel J, Kool ET, Wang D. Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues. Nucleic Acids Res. 2014 May; 42(9):5863-70. PMID: 24692664; PMCID: PMC4027217.
    12. Xu L, Chen YC, Nakajima S, Chong J, Wang L, Lan L, Zhang C, Wang D. A Chemical Probe Targets DNA 5-Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. Chem Sci. 2014 Feb 01; 5(2):567-574. PMID: 24883182.
      View in: PubMed
    13. Xu L, Plouffe SW, Chong J, Wengel J, Wang D. A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids. Angew Chem Int Ed Engl. 2013 Nov 18; 52(47):12341-5. PMID: 24167045; PMCID: PMC3866818.
    14. Kellinger MW, Park GY, Chong J, Lippard SJ, Wang D. Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis. J Am Chem Soc. 2013 Sep 04; 135(35):13054-61. PMID: 23927577; PMCID: PMC3791135.
    15. Zhang S, Wang D. Understanding the Molecular Basis of RNA Polymerase II Transcription. Isr J Chem. 2013 Jun; 53(6-7). PMID: 24403644.
      View in: PubMed
    16. Kellinger MW, Song CX, Chong J, Lu XY, He C, Wang D. 5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. Nat Struct Mol Biol. 2012 Aug; 19(8):831-3. PMID: 22820989; PMCID: PMC3414690.
    17. Kellinger MW, Ulrich S, Chong J, Kool ET, Wang D. Dissecting chemical interactions governing RNA polymerase II transcriptional fidelity. J Am Chem Soc. 2012 May 16; 134(19):8231-40. PMID: 22509745; PMCID: PMC3367139.
    18. Wang D, Zhu G, Huang X, Lippard SJ. X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9584-9. PMID: 20448203.
      View in: PubMed
    19. Liu X, Bushnell DA, Wang D, Calero G, Kornberg RD. Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism. Science. 2010 Jan 08; 327(5962):206-9. PMID: 19965383; PMCID: PMC2813267.
    20. Wang D, Bushnell DA, Huang X, Westover KD, Levitt M, Kornberg RD. Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science. 2009 May 29; 324(5931):1203-6. PMID: 19478184; PMCID: PMC2718261.
    21. Wang D, Bushnell DA, Westover KD, Kaplan CD, Kornberg RD. Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis. Cell. 2006 Dec 01; 127(5):941-54. PMID: 17129781.
      View in: PubMed
    22. Danford AJ, Wang D, Wang Q, Tullius TD, Lippard SJ. Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12311-6. PMID: 16116097; PMCID: PMC1194956.
    23. Takagi Y, Masuda CA, Chang WH, Komori H, Wang D, Hunter T, Joazeiro CA, Kornberg RD. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Mol Cell. 2005 Apr 15; 18(2):237-43. PMID: 15837426.
      View in: PubMed
    24. Wang D, Lippard SJ. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov. 2005 Apr; 4(4):307-20. PMID: 15789122.
      View in: PubMed
    25. Wang D, Lippard SJ. Cisplatin-induced post-translational modification of histones H3 and H4. J Biol Chem. 2004 May 14; 279(20):20622-5. PMID: 15010460.
      View in: PubMed
    26. Wang D, Hara R, Singh G, Sancar A, Lippard SJ. Nucleotide excision repair from site-specifically platinum-modified nucleosomes. Biochemistry. 2003 Jun 10; 42(22):6747-53. PMID: 12779329.
      View in: PubMed
    27. Lee KB, Wang D, Lippard SJ, Sharp PA. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4239-44. PMID: 11904382; PMCID: PMC123632.