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Dong Wang

Photo of Dong Wang
Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-2829-1546 Additional info
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    Collapse Biography 
    Collapse education and training
    Peking University B.S.1998Dept. of Chemistry
    Massachusetts Institute of TechnologyPh. D.2004Dept. of Chemistry
    Stanford University Postdoc2009School of Medicine, Dept. of Structural Biology
    Collapse awards and honors
    MIT2002  - 2003Anna Fuller Fund Graduate Fellowship Award
    Leukemia & Lymphoma Society 2007  - 2008Special Fellow Award
    NIH2008  - 2012NIH Pathway to Independence Award
    The Sidney Kimmel Foundation for Cancer Research 2012  - 2014Kimmel Scholar Award
    CAPA2015OKeanos-CAPA Young Investigator Award at the Chemical and Biology Interface

    Collapse Overview 
    Collapse overview
    Dr. Wang's research focuses on understanding the mechanisms of transcription regulation and cellular responses to DNA damage, particularly the functional interplay between transcription and DNA repair. His group takes a multidisciplinary approach, combining structural biology, chemical biology, computational biology, biochemical, and genetic methods, to study key protein complexes involved in these fundamental pathways. Moreover, understanding how cell process these DNA lesions will help us to decipher the mechanisms of drug action and resistance and pave the way for rational improvement of novel anticancer drugs.
    Collapse webpage

    Collapse Research 
    Collapse research activities and funding
    Molecular Mechanisms for DNA Damage Processing by Transcription Machinery
    NIH R01GM102362Jan 1, 2013 - Jan 31, 2022
    Role: Principal Investigator
    Structural Basis of Transcriptional Mutagenesis and Arrest of RNA Polymerase II
    NIH R00GM085136Jul 1, 2008 - Dec 31, 2012
    Role: Principal Investigator
    Structural Basis of Transcriptional Mutagenesis and Arrest of RNA Polymerase II
    NIH K99GM085136Jul 1, 2008 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mechanisms of transcription-coupled repair and DNA damage surveillance in health and disease. Nat Rev Mol Cell Biol. 2026 Mar; 27(3):234-251. van Sluis M, Gonzalo-Hansen C, Li Q, Lans H, Wang D, Marteijn JA. PMID: 41254380.
      View in: PubMed   Mentions:
    2. New Quantitative Cost-Impact Effectiveness Indexes to Assist in Publication Decisions by Researchers in the Open Access Era. bioRxiv. 2025 Oct 14. Hardy JC, Vu CK, Wang D. PMID: 41278829; PMCID: PMC12632794.
      View in: PubMed   Mentions:
    3. RNA polymerase II is a polar roadblock to a progressing DNA fork. Nat Commun. 2025 Sep 29; 16(1):8631. Kay TM, Inman JT, Lubkowska L, Le TT, Qian J, Hall PM, Batra S, Remus D, Wang D, Kashlev M, Wang MD. PMID: 41022786; PMCID: PMC12479915.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    4. Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing. Science. 2025 Sep 25; 389(6767):eadj9141. Shao C, Hao Y, Jiang L, Wang D, Wang R, Li Y, Wang H, Ge Y, Bai R, Du X, Chen X, Wu T, Gou LT, Wan R, Xu Y, Ji X, Fu XD. PMID: 40997183.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Transcription-Coupled Template Reconfiguration of 8-Oxoguanine for Error-Prone Transcription Revealed by Time-Resolved X-ray Crystallography and Molecular Dynamics. J Am Chem Soc. 2025 May 14; 147(19):16396-16403. Oh J, Konovalov KA, Hou P, Chong J, Huang X, Wang D. PMID: 40305462; PMCID: PMC12122184.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. ATM priming and end resection-coupled phosphorylation of MRE11 is important for fork protection and replication restart. Proc Natl Acad Sci U S A. 2025 Apr 22; 122(16):e2422720122. Zhang H, Li Y, Shah SB, Li S, Li Q, Oaks J, Lv T, Shi LZ, Wang H, Wang D, Wu X. PMID: 40249789; PMCID: PMC12037065.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Lysosomal PIP3 revealed by genetically encoded lipid biosensors. Proc Natl Acad Sci U S A. 2025 Apr; 122(13):e2426929122. Sahan AZ, Chen M, Su Q, Li Q, Wang D, Zhang J. PMID: 40127277; PMCID: PMC12002240.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Open architecture of archaea MCM and dsDNA complexes resolved using monodispersed streptavidin affinity CryoEM. Nat Commun. 2024 11 27; 15(1):10304. Ma J, Yi G, Ye M, MacGregor-Chatwin C, Sheng Y, Lu Y, Li M, Li Q, Wang D, Gilbert RJC, Zhang P. PMID: 39604363; PMCID: PMC11603195.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. RNA Polymerase II is a Polar Roadblock to a Progressing DNA Fork. bioRxiv. 2024 Oct 13. Kay TM, Inman JT, Lubkowska L, Le TT, Qian J, Hall PM, Wang D, Kashlev M, Wang MD. PMID: 39416093; PMCID: PMC11482878.
      View in: PubMed   Mentions:
    10. T7 RNA polymerase catalyzed transcription of the epimerizable DNA lesion, Fapy•dG and 8-oxo-2'-deoxyguanosine. J Biol Chem. 2024 09; 300(9):107719. Gao S, Hou P, Wang D, Greenberg MM. PMID: 39214306; PMCID: PMC11447338.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    11. Elf1 promotes transcription-coupled repair in yeast by using its C-terminal domain to bind TFIIH. Nat Commun. 2024 Jul 23; 15(1):6223. Selvam K, Xu J, Wilson HE, Oh J, Li Q, Wang D, Wyrick JJ. PMID: 39043658; PMCID: PMC11266705.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation. Nat Commun. 2024 Jul 17; 15(1):6031. Zhang X, Xu J, Hu J, Zhang S, Hao Y, Zhang D, Qian H, Wang D, Fu XD. PMID: 39019869; PMCID: PMC11255242.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. The Rapid Evolution of De Novo Proteins in Structure and Complex. Genome Biol Evol. 2024 06 04; 16(6). Chen J, Li Q, Xia S, Arsala D, Sosa D, Wang D, Long M. PMID: 38753069; PMCID: PMC11149777.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    14. Molecular determinants and signaling effects of PKA RIα phase separation. Mol Cell. 2024 Apr 18; 84(8):1570-1584.e7. Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, Zhang J. PMID: 38537638; PMCID: PMC11031308.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG. J Am Chem Soc. 2024 03 06; 146(9):6274-6282. Gao S, Hou P, Oh J, Wang D, Greenberg MM. PMID: 38393762; PMCID: PMC10932878.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Overcoming resolution attenuation during tilted cryo-EM data collection. Nat Commun. 2024 01 09; 15(1):389. Aiyer S, Baldwin PR, Tan SM, Shan Z, Oh J, Mehrani A, Bowman ME, Louie G, Passos DO, Ðordevic-Marquardt S, Mietzsch M, Hull JA, Hoshika S, Barad BA, Grotjahn DA, McKenna R, Agbandje-McKenna M, Benner SA, Noel JAP, Wang D, Tan YZ, Lyumkis D. PMID: 38195598; PMCID: PMC10776679.
      View in: PubMed   Mentions: 7     Fields:    
    17. Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3):e2314245121. Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE. PMID: 38194460; PMCID: PMC10801861.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase. Nat Commun. 2023 12 12; 14(1):8219. Oh J, Shan Z, Hoshika S, Xu J, Chong J, Benner SA, Lyumkis D, Wang D. PMID: 38086811; PMCID: PMC10716388.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    19. RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder. Proc Natl Acad Sci U S A. 2022 01 18; 119(3). Oh J, Jia T, Xu J, Chong J, Dervan PB, Wang D. PMID: 35022237; PMCID: PMC8784135.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    20. Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair. Nat Commun. 2021 12 01; 12(1):7001. Yan C, Dodd T, Yu J, Leung B, Xu J, Oh J, Wang D, Ivanov I. PMID: 34853308; PMCID: PMC8636621.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    21. A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models. J Biol Chem. 2021 Jan-Jun; 296:100735. Konovalov KA, Wang W, Wang G, Goonetilleke EC, Gao X, Wang D, Huang X. PMID: 33991521; PMCID: PMC8191312.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 05; 593(7859):418-423. Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. PMID: 33727703.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    23. FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis. J Immunol. 2021 03 15; 206(6):1228-1239. Milanovic M, Shao Z, Estes VM, Wang XS, Menolfi D, Lin X, Lee BJ, Xu J, Cupo OM, Wang D, Zha S. PMID: 33536256; PMCID: PMC9305077.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    24. The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange. Cancer Res. 2021 01 15; 81(2):426-437. Milanovic M, Sprinzen L, Menolfi D, Lee JH, Yamamoto K, Li Y, Lee BJ, Xu J, Estes VM, Wang D, Mckinnon PJ, Paull TT, Zha S. PMID: 33239428; PMCID: PMC8137556.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25486-25493. Xu J, Wang W, Xu L, Chen JY, Chong J, Oh J, Leschziner AE, Fu XD, Wang D. PMID: 32989164; PMCID: PMC7568279.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    26. A panorama of transcription-coupled repair in yeast chromatin. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):20991-20993. Wang D. PMID: 32817470; PMCID: PMC7474659.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-π and CH-π interactions. Proc Natl Acad Sci U S A. 2020 04 28; 117(17):9338-9348. Oh J, Fleming AM, Xu J, Chong J, Burrows CJ, Wang D. PMID: 32284409; PMCID: PMC7196775.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    28. RNA sequencing by direct tagmentation of RNA/DNA hybrids. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):2886-2893. Di L, Fu Y, Sun Y, Li J, Liu L, Yao J, Wang G, Wu Y, Lao K, Lee RW, Zheng G, Xu J, Oh J, Wang D, Xie XS, Huang Y, Wang J. PMID: 31988135; PMCID: PMC7022195.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    29. 3.1 Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids. J Struct Biol. 2019 09 01; 207(3):270-278. Lahiri I, Xu J, Han BG, Oh J, Wang D, DiMaio F, Leschziner AE. PMID: 31200019; PMCID: PMC6711803.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    30. Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair. DNA Repair (Amst). 2018 11; 71:43-55. Wang W, Xu J, Chong J, Wang D. PMID: 30174298; PMCID: PMC6340766.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    31. Structural basis of RNA polymerase I stalling at UV light-induced DNA damage. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):8972-8977. Sanz-Murillo M, Xu J, Belogurov GA, Calvo O, Gil-Carton D, Moreno-Morcillo M, Wang D, Fernández-Tornero C. PMID: 30127008; PMCID: PMC6130403.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    32. Identification of H3K4me1-associated proteins at mammalian enhancers. Nat Genet. 2018 01; 50(1):73-82. Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B. PMID: 29255264; PMCID: PMC6007000.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    33. Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 2017 11 30; 551(7682):653-657. Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. PMID: 29168508; PMCID: PMC5907806.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    34. Mechanism of transcription-coupled DNA modification recognition. Cell Biosci. 2017; 7:9. Shin JH, Xu L, Wang D. PMID: 28239446; PMCID: PMC5320713.
      View in: PubMed   Mentions: 10  
    35. Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors. Elife. 2016 06 15; 5. Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S. PMID: 27304073; PMCID: PMC4957979.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    36. Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue. Nat Commun. 2016 Apr 19; 7:11244. Da LT, Pardo-Avila F, Xu L, Silva DA, Zhang L, Gao X, Wang D, Huang X. PMID: 27091704; PMCID: PMC4838855.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    37. RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications. Crit Rev Biochem Mol Biol. 2015; 50(6):503-19. Xu L, Wang W, Chong J, Shin JH, Xu J, Wang D. PMID: 26392149; PMCID: PMC4891981.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    38. Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes. PLoS Comput Biol. 2015 Jul; 11(7):e1004354. Zhang L, Silva DA, Pardo-Avila F, Wang D, Huang X. PMID: 26134169; PMCID: PMC4489626.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    39. Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 2015 Jul 30; 523(7562):621-5. Wang L, Zhou Y, Xu L, Xiao R, Lu X, Chen L, Chong J, Li H, He C, Fu XD, Wang D. PMID: 26123024; PMCID: PMC4521995.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    40. Impact of template backbone heterogeneity on RNA polymerase II transcription. Nucleic Acids Res. 2015 Feb 27; 43(4):2232-41. Xu L, Wang W, Zhang L, Chong J, Huang X, Wang D. PMID: 25662224; PMCID: PMC4344504.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    41. Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):E410-9. Walmacq C, Wang L, Chong J, Scibelli K, Lubkowska L, Gnatt A, Brooks PJ, Wang D, Kashlev M. PMID: 25605892; PMCID: PMC4321233.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    42. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18566-71. Wang L, Limbo O, Fei J, Chen L, Kim B, Luo J, Chong J, Conaway RC, Conaway JW, Ranish JA, Kadonaga JT, Russell P, Wang D. PMID: 25512493; PMCID: PMC4284531.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    43. Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation. Angew Chem Int Ed Engl. 2014 Oct 13; 53(42):11223-7. Xu L, Chen YC, Chong J, Fin A, McCoy LS, Xu J, Zhang C, Wang D. PMID: 25159856; PMCID: PMC4227401.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    44. Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3269-76. Xu L, Zhang L, Chong J, Xu J, Huang X, Wang D. PMID: 25074911; PMCID: PMC4136571.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    45. Molecular dynamics simulation study of conformational changes of transcription factor TFIIS during RNA polymerase II transcriptional arrest and reactivation. PLoS One. 2014; 9(5):e97975. Eun C, Ortiz-Sánchez JM, Da L, Wang D, McCammon JA. PMID: 24842057; PMCID: PMC4026522.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    46. Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis. DNA Repair (Amst). 2014 Jul; 19:71-83. Xu L, Da L, Plouffe SW, Chong J, Kool E, Wang D. PMID: 24767259; PMCID: PMC4051827.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    47. Millisecond dynamics of RNA polymerase II translocation at atomic resolution. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7665-70. Silva DA, Weiss DR, Pardo Avila F, Da LT, Levitt M, Wang D, Huang X. PMID: 24753580; PMCID: PMC4040580.
      View in: PubMed   Mentions: 75     Fields:    Translation:Cells
    48. Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues. Nucleic Acids Res. 2014 May; 42(9):5863-70. Xu L, Butler KV, Chong J, Wengel J, Kool ET, Wang D. PMID: 24692664; PMCID: PMC4027217.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    49. A Chemical Probe Targets DNA 5-Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. Chem Sci. 2014 Feb 01; 5(2):567-574. Xu L, Chen YC, Nakajima S, Chong J, Wang L, Lan L, Zhang C, Wang D. PMID: 24883182; PMCID: PMC4038700.
      View in: PubMed   Mentions: 8  
    50. A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids. Angew Chem Int Ed Engl. 2013 Nov 18; 52(47):12341-5. Xu L, Plouffe SW, Chong J, Wengel J, Wang D. PMID: 24167045; PMCID: PMC3866818.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    51. Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis. J Am Chem Soc. 2013 Sep 04; 135(35):13054-61. Kellinger MW, Park GY, Chong J, Lippard SJ, Wang D. PMID: 23927577; PMCID: PMC3791135.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    52. Understanding the Molecular Basis of RNA Polymerase II Transcription. Isr J Chem. 2013 Jun; 53(6-7). Zhang S, Wang D. PMID: 24403644; PMCID: PMC3881536.
      View in: PubMed   Mentions: 8  
    53. 5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. Nat Struct Mol Biol. 2012 Aug; 19(8):831-3. Kellinger MW, Song CX, Chong J, Lu XY, He C, Wang D. PMID: 22820989; PMCID: PMC3414690.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    54. Dissecting chemical interactions governing RNA polymerase II transcriptional fidelity. J Am Chem Soc. 2012 May 16; 134(19):8231-40. Kellinger MW, Ulrich S, Chong J, Kool ET, Wang D. PMID: 22509745; PMCID: PMC3367139.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    55. X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9584-9. Wang D, Zhu G, Huang X, Lippard SJ. PMID: 20448203; PMCID: PMC2906855.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    56. Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism. Science. 2010 Jan 08; 327(5962):206-9. Liu X, Bushnell DA, Wang D, Calero G, Kornberg RD. PMID: 19965383; PMCID: PMC2813267.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    57. Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution. Science. 2009 May 29; 324(5931):1203-6. Wang D, Bushnell DA, Huang X, Westover KD, Levitt M, Kornberg RD. PMID: 19478184; PMCID: PMC2718261.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    58. Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis. Cell. 2006 Dec 01; 127(5):941-54. Wang D, Bushnell DA, Westover KD, Kaplan CD, Kornberg RD. PMID: 17129781; PMCID: PMC1876690.
      View in: PubMed   Mentions: 276     Fields:    Translation:AnimalsCells
    59. Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12311-6. Danford AJ, Wang D, Wang Q, Tullius TD, Lippard SJ. PMID: 16116097; PMCID: PMC1194956.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    60. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Mol Cell. 2005 Apr 15; 18(2):237-43. Takagi Y, Masuda CA, Chang WH, Komori H, Wang D, Hunter T, Joazeiro CA, Kornberg RD. PMID: 15837426.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    61. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov. 2005 Apr; 4(4):307-20. Wang D, Lippard SJ. PMID: 15789122.
      View in: PubMed   Mentions: 1114     Fields:    Translation:HumansAnimalsCells
    62. Cisplatin-induced post-translational modification of histones H3 and H4. J Biol Chem. 2004 May 14; 279(20):20622-5. Wang D, Lippard SJ. PMID: 15010460.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    63. Nucleotide excision repair from site-specifically platinum-modified nucleosomes. Biochemistry. 2003 Jun 10; 42(22):6747-53. Wang D, Hara R, Singh G, Sancar A, Lippard SJ. PMID: 12779329.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    64. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4239-44. Lee KB, Wang D, Lippard SJ, Sharp PA. PMID: 11904382; PMCID: PMC123632.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
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