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Mark Tuszynski
Title
Professor
School
University of California, San Diego
Department
Neurosciences
Address
9500 Gilman Drive #0626
CA La Jolla 92093
Phone
858-534-8857
vCard
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Research
Research Activities and Funding
ShEEP request for a Zeiss LSM 880 with Airyscan confocal system
VA
IS1BX004001
Jan 1, 2018 - Sep 30, 2018
Role: Principal Investigator
Embryonic stem cell therapy after cervical contusion SCI in NHPs
NIH/NINDS
R01NS105478
Sep 25, 2017 - Jun 30, 2022
Role: Co-Principal Investigator
3D Printed Scaffolds for Primate Spinal Cord Injury
NIH/NINDS
R03NS104972
Sep 22, 2017 - Aug 31, 2019
Role: Principal Investigator
The Primate Corticospinal Connectome
NIH/NINDS
R01NS104442
Sep 15, 2017 - May 31, 2021
Role: Principal Investigator
The VA Gordon Mansfield SCI Consortium
VA
I50RX001706
Jul 1, 2015 - Jun 30, 2020
Role: Principal Investigator
Acquisition of a Keyence BZ-X700 All-In-One Automated Imaging System
VA
IS1BX003125
Jan 1, 2015 - Sep 30, 2015
Role: Principal Investigator
A Translational Program of BDNF Gene Delivery in Alzheimer's Disease
NIH/NIA
U01AG043416
Jun 15, 2014 - May 31, 2019
Role: Principal Investigator
Bioengineered Scaffolds for Spinal Cord Injury
NIH/NIBIB
R01EB014986
May 15, 2012 - Apr 30, 2017
Role: Principal Investigator
Contusive Spinal Cord Injury Model Development
VA
I01RX000434
Oct 1, 2010 - Sep 30, 2012
Role: Principal Investigator
Combinatorial Approaches to SCI
NIH/NINDS
R01NS049881
Aug 3, 2004 - Apr 30, 2010
Role: Principal Investigator
Plasticity and Regeneration in the Primate Spinal Cord
NIH/NINDS
R56NS042291
Sep 1, 2001 - Mar 31, 2018
Role: Principal Investigator
Plasticity and Regeneration in the Primate Spinal Cord
NIH/NINDS
R01NS042291
Sep 1, 2001 - Mar 31, 2016
Role: Principal Investigator
Netrins and Gene Therapy After Spinal Cord Injury
NIH/NINDS
R21NS042038
Jul 15, 2001 - Jun 30, 2004
Role: Principal Investigator
Neurobiological Aspects of Aging
NIH/NIA
K12AG000975
Apr 1, 2000 - Mar 31, 2012
Role: Principal Investigator
EX VIVO SCHWANN CELL GENE THERAPY FOR CNS REPAIR
NIH/NINDS
R01NS037083
Dec 1, 1997 - Nov 30, 2001
Role: Principal Investigator
Gene Therapy for Alzheimer's Disease
NIH/NIA
P01AG010435
Sep 30, 1991 - Mar 31, 2015
Role: Principal Investigator
CHOLINERGIC NEURONAL REGENERATION IN THE CNS
NIH/NINDS
F32NS008200
Oct 21, 1987
Role: Principal Investigator
UCSD Alzheimer's Disease Research Center P50
NIH/NIA
P50AG005131
Sep 28, 1984 - Mar 31, 2019
Role: Co-Investigator
California National Primate Research Center
NIH
P51RR000169
Jun 1, 1975 - Apr 30, 2015
Role: Co-Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Lu P, Ceto S, Wang Y, Graham L, Wu D, Kumamaru H, Staufenberg E,
Tuszynski M
. Prolonged human neural stem cell maturation supports recovery in injured rodent CNS. J Clin Invest. 2017 Sep 01; 127(9):3287-3299. PMID: 28825600.
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PubMed
Hunt M, Lu P,
Tuszynski M
. Myelination of axons emerging from neural progenitor grafts after spinal cord injury. Exp Neurol. 2017 Oct; 296:69-73. PMID: 28698030.
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PubMed
Adler AF, Lee-Kubli C, Kumamaru H, Kadoya K,
Tuszynski M
. Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury. Stem Cell Reports. 2017 Jun 06; 8(6):1525-1533. PMID: 28479302.
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PubMed
Lu P,
Tuszynski M
. Introduction to neuroscience letters special issue: "Plasticity and regeneration after spinal cord injury". Neurosci Lett. 2017 Jun 23; 652:1-2. PMID: 28432027.
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PubMed
Hollis Ii ER, Kadoya K, Hirsch M, Samulski RJ,
Tuszynski M
. Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1. Mol Ther. 2008 Feb; 16(2):296-301. PMID: 28178539.
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PubMed
Gao M, Lu P, Lynam D, Bednark B, Campana WM, Sakamoto J,
Tuszynski M
. BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration. J Neural Eng. 2016 Dec; 13(6):066011. PMID: 27762235.
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PubMed
Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M,
Tuszynski M
, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 06 02; 534(7605):115-8. PMID: 27251287.
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PubMed
Kadoya K, Lu P, Nguyen K, Lee-Kubli C, Kumamaru H, Yao L, Knackert J, Poplawski G, Dulin JN, Strobl H, Takashima Y, Biane J, Conner J, Zhang SC,
Tuszynski M
. Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nat Med. 2016 May; 22(5):479-87. PMID: 27019328; PMCID: PMC4860037.
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PubMed
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PubMed Central
Biane JS, Takashima Y, Scanziani M, Conner JM,
Tuszynski M
. Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning. Neuron. 2016 Mar 16; 89(6):1173-1179. PMID: 26948893; PMCID: PMC4795975 [Available on 03/16/17].
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PubMed
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PubMed Central
Wang L, Conner JM, Nagahara AH,
Tuszynski M
. Rehabilitation drives enhancement of neuronal structure in functionally relevant neuronal subsets. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2750-5. PMID: 26903653; PMCID: PMC4790976.
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PubMed
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PubMed Central
Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M,
Tuszynski M
, Woolf CJ, Geschwind DH. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 02; 89(5):956-70. PMID: 26898779; PMCID: PMC4790095 [Available on 03/02/17].
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PubMed
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PubMed Central
Lee-Kubli CA, Ingves M, Henry KW, Shiao R, Collyer E,
Tuszynski M
, Campana WM. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016 Apr; 278:91-104. PMID: 26808661.
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PubMed
Salegio EA, Bresnahan JC, Sparrey CJ, Camisa W, Fischer J, Leasure J, Buckley J, Nout-Lomas YS, Rosenzweig ES, Moseanko R, Strand S, Hawbecker S, Lemoy MJ, Haefeli J, Ma X, Nielson JL, Edgerton VR, Ferguson AR,
Tuszynski M
, Beattie MS. A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta). J Neurotrauma. 2016 Mar 01; 33(5):439-59. PMID: 26788611; PMCID: PMC4799702.
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PubMed
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PubMed Central
van Niekerk EA,
Tuszynski M
, Lu P, Dulin JN. Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury. Mol Cell Proteomics. 2016 Feb; 15(2):394-408. PMID: 26695766; PMCID: PMC4739663 [Available on 02/01/17].
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PubMed
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PubMed Central
Brock JH, Graham L, Staufenberg E, Collyer E, Koffler J,
Tuszynski M
. Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury. J Neurotrauma. 2016 Jun 15; 33(12):1103-14. PMID: 26414795; PMCID: PMC4904236 [Available on 06/15/17].
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PubMed
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PubMed Central
Dulin JN, Antunes-Martins A, Chandran V, Costigan M, Lerch JK, Willis DE,
Tuszynski M
. Transcriptomic Approaches to Neural Repair. J Neurosci. 2015 Oct 14; 35(41):13860-7. PMID: 26468186; PMCID: PMC4604224.
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PubMed
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PubMed Central
Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC, Bézard E, Bloch J, Edgerton VR, Ferguson AR, Curt A,
Tuszynski M
, Courtine G. Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates. Sci Transl Med. 2015 Aug 26; 7(302):302ra134. PMID: 26311729.
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PubMed
Biane JS, Scanziani M,
Tuszynski M
, Conner JM. Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability. J Neurosci. 2015 Mar 18; 35(11):4719-28. PMID: 25788688; PMCID: PMC4363396.
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PubMed
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PubMed Central
Ramanathan DS, Conner JM, Anilkumar AA,
Tuszynski M
. Cholinergic systems are essential for late-stage maturation and refinement of motor cortical circuits. J Neurophysiol. 2015 Mar 01; 113(5):1585-97. PMID: 25505106; PMCID: PMC4346727.
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PubMed
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PubMed Central
Nielson JL, Haefeli J, Salegio EA, Liu AW, Guandique CF, Stück ED, Hawbecker S, Moseanko R, Strand SC, Zdunowski S, Brock JH, Roy RR, Rosenzweig ES, Nout-Lomas YS, Courtine G, Havton LA, Steward O, Reggie Edgerton V,
Tuszynski M
, Beattie MS, Bresnahan JC, Ferguson AR. Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury. Brain Res. 2015 Sep 04; 1619:124-38. PMID: 25451131; PMCID: PMC4418964.
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PubMed
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PubMed Central
Biane J, Conner JM,
Tuszynski M
. Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex. Front Cell Neurosci. 2014; 8:220. PMID: 25147503; PMCID: PMC4124705.
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PubMed
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PubMed Central
Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, Whittemore SR, McTigue DM, Popovich PG, Rabchevsky AG, Scheff SW, Steward O, Courtine G, Edgerton VR,
Tuszynski M
, Beattie MS, Bresnahan JC, Ferguson AR. Development of a database for translational spinal cord injury research. J Neurotrauma. 2014 Nov 01; 31(21):1789-99. PMID: 25077610; PMCID: PMC4186058.
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PubMed
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PubMed Central
Tuszynski M
, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cells in models of spinal cord injury. Exp Neurol. 2014 Nov; 261:494-500. PMID: 25079369.
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PubMed
Lu P, Graham L, Wang Y, Wu D,
Tuszynski M
. Promotion of survival and differentiation of neural stem cells with fibrin and growth factor cocktails after severe spinal cord injury. J Vis Exp. 2014 Jul 27; (89):e50641. PMID: 25145787; PMCID: PMC4435462.
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PubMed
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PubMed Central
Lu P, Kadoya K,
Tuszynski M
. Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury. Curr Opin Neurobiol. 2014 Aug; 27:103-9. PMID: 24709371.
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PubMed
Tuszynski M
, Wang Y, Graham L, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cell dissemination after grafting to CNS injury sites. Cell. 2014 Jan 30; 156(3):388-9. PMID: 24485445.
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PubMed
Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E,
Tuszynski M
. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci. 2013 Sep 25; 33(39):15596-602. PMID: 24068826; PMCID: PMC3782628.
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PubMed
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PubMed Central
Do JL, Bonni A,
Tuszynski M
. SnoN facilitates axonal regeneration after spinal cord injury. PLoS One. 2013; 8(8):e71906. PMID: 23936531; PMCID: PMC3732222.
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PubMed
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PubMed Central
Yoon C, Van Niekerk EA, Henry K, Ishikawa T, Orita S,
Tuszynski M
, Campana WM. Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. J Biol Chem. 2013 Sep 13; 288(37):26557-68. PMID: 23867460; PMCID: PMC3772203.
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PubMed
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PubMed Central
Gao M, Lu P, Bednark B, Lynam D, Conner JM, Sakamoto J,
Tuszynski M
. Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection. Biomaterials. 2013 Feb; 34(5):1529-36. PMID: 23182350; PMCID: PMC3518618.
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PubMed
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PubMed Central
Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M,
Tuszynski M
. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14; 150(6):1264-73. PMID: 22980985; PMCID: PMC3445432.
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PubMed
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PubMed Central
Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ,
Tuszynski M
, Huang K. JNK3 perpetuates metabolic stress induced by Aß peptides. Neuron. 2012 Sep 06; 75(5):824-37. PMID: 22958823; PMCID: PMC3438522.
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PubMed
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PubMed Central
Lu P, Blesch A, Graham L, Wang Y, Samara R, Banos K, Haringer V, Havton L, Weishaupt N, Bennett D, Fouad K,
Tuszynski M
. Motor axonal regeneration after partial and complete spinal cord transection. J Neurosci. 2012 Jun 13; 32(24):8208-18. PMID: 22699902; PMCID: PMC3407545.
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PubMed
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PubMed Central
Tuszynski M
, Steward O. Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012 Jun 07; 74(5):777-91. PMID: 22681683; PMCID: PMC3387806.
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PubMed
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PubMed Central
Nout YS, Rosenzweig ES, Brock JH, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Courtine G, Ferguson AR, Edgerton VR, Beattie MS, Bresnahan JC,
Tuszynski M
. Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury. Neurotherapeutics. 2012 Apr; 9(2):380-92. PMID: 22427157; PMCID: PMC3337011.
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PubMed
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PubMed Central
Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, Brock JH, Courtine G, Edgerton VR,
Tuszynski M
, Beattie MS, Bresnahan JC. Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey. Neurorehabil Neural Repair. 2012 Jul-Aug; 26(6):556-69. PMID: 22331214; PMCID: PMC3468651.
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PubMed
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PubMed Central
Blesch A, Fischer I,
Tuszynski M
. Gene therapy, neurotrophic factors and spinal cord regeneration. Handb Clin Neurol. 2012; 109:563-74. PMID: 23098737.
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PubMed
Blesch A, Lu P, Tsukada S, Alto LT, Roet K, Coppola G, Geschwind D,
Tuszynski M
. Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects. Exp Neurol. 2012 May; 235(1):162-73. PMID: 22227059; PMCID: PMC3334479.
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PubMed
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PubMed Central
Hollis ER,
Tuszynski M
. Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury. Neurotherapeutics. 2011 Oct; 8(4):694-703. PMID: 21904786; PMCID: PMC3250295.
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PubMed
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PubMed Central
Nagahara AH,
Tuszynski M
. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov. 2011 Mar; 10(3):209-19. PMID: 21358740.
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PubMed
Wang L, Conner JM, Rickert J,
Tuszynski M
. Structural plasticity within highly specific neuronal populations identifies a unique parcellation of motor learning in the adult brain. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2545-50. PMID: 21257908; PMCID: PMC3038698.
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PubMed
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PubMed Central
Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR,
Tuszynski M
. Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci. 2010 Dec; 13(12):1505-10. PMID: 21076427; PMCID: PMC3144760.
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PubMed
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PubMed Central
Brock JH, Rosenzweig ES, Blesch A, Moseanko R, Havton LA, Edgerton VR,
Tuszynski M
. Local and remote growth factor effects after primate spinal cord injury. J Neurosci. 2010 Jul 21; 30(29):9728-37. PMID: 20660255; PMCID: PMC2927098.
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PubMed
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PubMed Central
Gros T, Sakamoto JS, Blesch A, Havton LA,
Tuszynski M
. Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds. Biomaterials. 2010 Sep; 31(26):6719-29. PMID: 20619785.
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PubMed
Hollis ER, Jamshidi P, Lorenzana AO, Lee JK, Gray SJ, Samulski RJ, Zheng B,
Tuszynski M
. Transient demyelination increases the efficiency of retrograde AAV transduction. Mol Ther. 2010 Aug; 18(8):1496-500. PMID: 20502445; PMCID: PMC2927074.
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PubMed
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PubMed Central
Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A,
Tuszynski M
. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 2009 Oct 29; 64(2):165-72. PMID: 19874785; PMCID: PMC2773653.
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PubMed
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PubMed Central
Conner JM, Franks KM, Titterness AK, Russell K, Merrill DA, Christie BR, Sejnowski TJ,
Tuszynski M
. NGF is essential for hippocampal plasticity and learning. J Neurosci. 2009 Sep 02; 29(35):10883-9. PMID: 19726646; PMCID: PMC2765804.
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PubMed
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PubMed Central
Alfa RW,
Tuszynski M
, Blesch A. A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth. J Neurosci Res. 2009 Sep; 87(12):2624-31. PMID: 19405107; PMCID: PMC2854653.
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PubMed
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PubMed Central
Alto LT, Havton LA, Conner JM, Hollis ER, Blesch A,
Tuszynski M
. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci. 2009 Sep; 12(9):1106-13. PMID: 19648914; PMCID: PMC2753201.
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PubMed
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PubMed Central
Ramanathan D,
Tuszynski M
, Conner JM. The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. J Neurosci. 2009 May 06; 29(18):5992-6000. PMID: 19420265.
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PubMed
Hollis ER, Jamshidi P, Löw K, Blesch A,
Tuszynski M
. Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7215-20. PMID: 19359495; PMCID: PMC2678459.
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PubMed
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PubMed Central
Merrill DA, Masliah E, Roberts JA, McKay H, Kordower JH, Mufson EJ,
Tuszynski M
. Association of early experience with neurodegeneration in aged primates. Neurobiol Aging. 2011 Jan; 32(1):151-6. PMID: 19321231; PMCID: PMC4210191.
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PubMed
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PubMed Central
Rosenzweig ES, Brock JH, Culbertson MD, Lu P, Moseanko R, Edgerton VR, Havton LA,
Tuszynski M
. Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys. J Comp Neurol. 2009 Mar 10; 513(2):151-63. PMID: 19125408; PMCID: PMC2706096.
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PubMed
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PubMed Central
Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA,
Tuszynski M
. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar; 15(3):331-7. PMID: 19198615; PMCID: PMC2838375.
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PubMed
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PubMed Central
Blesch A,
Tuszynski M
. Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci. 2009 Jan; 32(1):41-7. PMID: 18977039.
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PubMed
Nagahara AH, Bernot T, Moseanko R, Brignolo L, Blesch A, Conner JM, Ramirez A, Gasmi M,
Tuszynski M
. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp Neurol. 2009 Jan; 215(1):153-9. PMID: 19013154; PMCID: PMC2632603.
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PubMed
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PubMed Central
Hollis ER, Lu P, Blesch A,
Tuszynski M
. IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp Neurol. 2009 Jan; 215(1):53-9. PMID: 18938163; PMCID: PMC2632606.
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PubMed
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PubMed Central
Nagahara AH, Bernot T,
Tuszynski M
. Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery. Neurobiol Aging. 2010 Jun; 31(6):1020-31. PMID: 18760505; PMCID: PMC2876823.
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PubMed
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PubMed Central
Herzog CD, Dass B, Gasmi M, Bakay R, Stansell JE,
Tuszynski M
, Bankiewicz K, Chen EY, Chu Y, Bishop K, Kordower JH, Bartus RT. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Mol Ther. 2008 Oct; 16(10):1737-44. PMID: 18728639.
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PubMed
Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG,
Tuszynski M
, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J, Khachaturian AS, Bain LJ. A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement. 2008 May; 4(3):156-63. PMID: 18631960; PMCID: PMC2544623.
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PubMed
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PubMed Central
Bishop KM, Hofer EK, Mehta A, Ramirez A, Sun L,
Tuszynski M
, Bartus RT. Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons. Exp Neurol. 2008 Jun; 211(2):574-84. PMID: 18439998; PMCID: PMC2709503.
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PubMed
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PubMed Central
Löw K, Culbertson M, Bradke F, Tessier-Lavigne M,
Tuszynski M
. Netrin-1 is a novel myelin-associated inhibitor to axon growth. J Neurosci. 2008 Jan 30; 28(5):1099-108. PMID: 18234888.
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PubMed
Hollis ER, Kadoya K, Hirsch M, Samulski RJ,
Tuszynski M
. Efficient retrograde neuronal transduction utilizing self-complementary AAV1. Mol Ther. 2008 Feb; 16(2):296-301. PMID: 18223548.
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Blesch A,
Tuszynski M
. Transient growth factor delivery sustains regenerated axons after spinal cord injury. J Neurosci. 2007 Sep 26; 27(39):10535-45. PMID: 17898225.
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Lu P,
Tuszynski M
. Growth factors and combinatorial therapies for CNS regeneration. Exp Neurol. 2008 Feb; 209(2):313-20. PMID: 17927983; PMCID: PMC2408882.
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,
PubMed Central
Tuszynski M
. Nerve growth factor gene delivery: animal models to clinical trials. Dev Neurobiol. 2007 Aug; 67(9):1204-15. PMID: 17514712.
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Herzog CD, Dass B, Holden JE, Stansell J, Gasmi M,
Tuszynski M
, Bartus RT, Kordower JH. Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. Mov Disord. 2007 Jun 15; 22(8):1124-32. PMID: 17443702.
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Tuszynski M
. Nerve growth factor gene therapy in Alzheimer disease. Alzheimer Dis Assoc Disord. 2007 Apr-Jun; 21(2):179-89. PMID: 17545746.
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Bartus RT, Herzog CD, Bishop K, Ostrove JM,
Tuszynski M
, Kordower JH, Gasmi M. Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point. Parkinsonism Relat Disord. 2007; 13 Suppl 3:S469-77. PMID: 18267286.
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Blurton-Jones M,
Tuszynski M
. Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. J Comp Neurol. 2006 Dec 01; 499(4):603-12. PMID: 17029253.
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Tuszynski M
. Challenges to the report of Nogo antibody effects in primates. Nat Med. 2006 Nov; 12(11):1231-2; author reply 1232-3. PMID: 17088880.
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Lu P, Yang H, Culbertson M, Graham L, Roskams AJ,
Tuszynski M
. Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury. J Neurosci. 2006 Oct 25; 26(43):11120-30. PMID: 17065452.
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Lu P, Jones LL,
Tuszynski M
. Axon regeneration through scars and into sites of chronic spinal cord injury. Exp Neurol. 2007 Jan; 203(1):8-21. PMID: 17014846.
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Stokols S, Sakamoto J, Breckon C, Holt T, Weiss J,
Tuszynski M
. Templated agarose scaffolds support linear axonal regeneration. Tissue Eng. 2006 Oct; 12(10):2777-87. PMID: 17518647.
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Taylor L, Jones L,
Tuszynski M
, Blesch A. Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci. 2006 Sep 20; 26(38):9713-21. PMID: 16988042.
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Ramanathan D, Conner JM,
Tuszynski M
. A form of motor cortical plasticity that correlates with recovery of function after brain injury. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11370-5. PMID: 16837575; PMCID: PMC1544093.
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,
PubMed Central
Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR,
Tuszynski M
. Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66. PMID: 16495442.
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Stokols S,
Tuszynski M
. Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury. Biomaterials. 2006 Jan; 27(3):443-51. PMID: 16099032.
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Courtine G, Roy RR, Raven J, Hodgson J, McKay H, Yang H, Zhong H,
Tuszynski M
, Edgerton VR. Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta). Brain. 2005 Oct; 128(Pt 10):2338-58. PMID: 16049043.
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Blesch A, Conner J, Pfeifer A, Gasmi M, Ramirez A, Britton W, Alfa R, Verma I,
Tuszynski M
. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Mol Ther. 2005 Jun; 11(6):916-25. PMID: 15922962.
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Tuszynski M
, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon J, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med. 2005 May; 11(5):551-5. PMID: 15852017.
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Conner JM, Chiba AA,
Tuszynski M
. The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury. Neuron. 2005 Apr 21; 46(2):173-9. PMID: 15848797.
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Courtine G, Roy RR, Hodgson J, McKay H, Raven J, Zhong H, Yang H,
Tuszynski M
, Edgerton VR. Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus). J Neurophysiol. 2005 Jun; 93(6):3127-45. PMID: 15647397.
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Tuszynski M
. New strategies for CNS repair. Ernst Schering Res Found Workshop. 2005; (53):1-10. PMID: 16315605.
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Stokols S,
Tuszynski M
. The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury. Biomaterials. 2004 Dec; 25(27):5839-46. PMID: 15172496.
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Lu P, Blesch A,
Tuszynski M
. Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact? J Neurosci Res. 2004 Jul 15; 77(2):174-91. PMID: 15211585.
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Lu P, Yang H, Jones LL, Filbin MT,
Tuszynski M
. Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci. 2004 Jul 14; 24(28):6402-9. PMID: 15254096.
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Blesch A,
Tuszynski M
. Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury. Yonsei Med J. 2004 Jun 30; 45 Suppl:28-31. PMID: 15250047.
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Lacroix S, Havton LA, McKay H, Yang H, Brant A, Roberts J,
Tuszynski M
. Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study. J Comp Neurol. 2004 May 24; 473(2):147-61. PMID: 15101086.
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Nagahara A,
Tuszynski M
. The ageless question--what accounts for age-related cognitive decline? Sci Aging Knowledge Environ. 2004 May 12; 2004(19):pe20. PMID: 15141075.
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Smith DE, Rapp PR, McKay HM, Roberts JA,
Tuszynski M
. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J Neurosci. 2004 May 05; 24(18):4373-81. PMID: 15128851.
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Blesch A,
Tuszynski M
. Nucleus hears axon's pain. Nat Med. 2004 Mar; 10(3):236-7. PMID: 14991043.
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Tuszynski M
, Blesch A. Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease. Prog Brain Res. 2004; 146:441-9. PMID: 14699979.
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Blesch A,
Tuszynski M
. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol. 2003 Dec 15; 467(3):403-17. PMID: 14608602.
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Jones LL, Sajed D,
Tuszynski M
. Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition. J Neurosci. 2003 Oct 15; 23(28):9276-88. PMID: 14561854.
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Tuszynski M
. Gene therapy for neurological disease. Expert Opin Biol Ther. 2003 Aug; 3(5):815-28. PMID: 12880381.
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Jones LL, Margolis RU,
Tuszynski M
. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol. 2003 Aug; 182(2):399-411. PMID: 12895450.
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Conner JM, Culberson A, Packowski C, Chiba AA,
Tuszynski M
. Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron. 2003 Jun 05; 38(5):819-29. PMID: 12797965.
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Tuszynski M
, Grill R, Jones LL, Brant A, Blesch A, Löw K, Lacroix S, Lu P. NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Exp Neurol. 2003 May; 181(1):47-56. PMID: 12710933.
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Merrill DA, Karim R, Darraq M, Chiba AA,
Tuszynski M
. Hippocampal cell genesis does not correlate with spatial learning ability in aged rats. J Comp Neurol. 2003 Apr 28; 459(2):201-7. PMID: 12640670.
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Lacroix S, Chang L, Rose-John S,
Tuszynski M
. Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth. J Comp Neurol. 2002 Dec 16; 454(3):213-28. PMID: 12442313.
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Tuszynski M
, U HS, Alksne J, Bakay RA, Pay MM, Merrill D, Thal LJ. Growth factor gene therapy for Alzheimer disease. Neurosurg Focus. 2002 Nov 15; 13(5):e5. PMID: 15769074.
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PubMed
Blurton-Jones M,
Tuszynski M
. Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. J Comp Neurol. 2002 Oct 21; 452(3):276-87. PMID: 12353223.
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Tuszynski M
, Thal L, U HS, Pay MM, Blesch A, Conner J, Vahlsing HL. Nerve growth factor gene therapy for Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):207. PMID: 12212782.
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Tuszynski M
, Grill R, Jones LL, McKay HM, Blesch A. Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts. J Comp Neurol. 2002 Jul 15; 449(1):88-101. PMID: 12115695.
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Jones LL,
Tuszynski M
. Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors. J Neurosci. 2002 Jun 01; 22(11):4611-24. PMID: 12040068.
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Tuszynski M
. Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol. 2002 May; 1(1):51-7. PMID: 12849545.
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PubMed
Jones LL, Yamaguchi Y, Stallcup WB,
Tuszynski M
. NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci. 2002 Apr 01; 22(7):2792-803. PMID: 11923444.
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Blesch A, Lu P,
Tuszynski M
. Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull. 2002 Apr; 57(6):833-8. PMID: 12031281.
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PubMed
Tuszynski M
, Conner J, Blesch A, Smith D, Merrill DA, Vahlsing HL. New strategies in neural repair. Prog Brain Res. 2002; 138:401-9. PMID: 12432780.
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PubMed
Blesch A,
Tuszynski M
. Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog Brain Res. 2002; 137:415-23. PMID: 12440384.
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PubMed
Merrill DA, Blesch A,
Tuszynski M
. Therapeutic potential of nervous system growth factors for neurodegenerative disease. Expert Rev Neurother. 2002 Jan; 2(1):89-96. PMID: 19811018.
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PubMed
Tuszynski M
. Proceedings of the Meeting of the American Society for Neural Transplantation and Repair (ASNTR), 1999. Cell Transplant. 2000 Sep; 9(5):565-566. PMID: 28880660.
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Concepts
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Genetic Therapy
Rats, Inbred F344
Axons
Spinal Cord Injuries
Nerve Regeneration
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Kadoya, Ken
Ramanathan, Dhakshin
Rosenzweig, Ephron
Brock, John
Nagahara, Alan
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