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    Mark Tuszynski

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentNeurosciences
    Address9500 Gilman Drive #0626
    CA La Jolla 92093
    Phone858-534-8857
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      The VA Gordon Mansfield SCI Consortium
      NIH I50RX001706Jul 1, 2015 - Jun 30, 2020
      Role: Principal Investigator
      Acquisition of a Keyence BZ-X700 All-In-One Automated Imaging System
      NIH IS1BX003125Jan 1, 2015 - Sep 30, 2015
      Role: Principal Investigator
      A Translational Program of BDNF Gene Delivery in Alzheimer's Disease
      NIH U01AG043416Jun 15, 2014 - May 31, 2019
      Role: Principal Investigator
      Bioengineered Scaffolds for Spinal Cord Injury
      NIH R01EB014986May 15, 2012 - Apr 30, 2017
      Role: Principal Investigator
      Contusive Spinal Cord Injury Model Development
      NIH I01RX000434Oct 1, 2010 - Sep 30, 2012
      Role: Principal Investigator
      Combinatorial Approaches to SCI
      NIH R01NS049881Aug 3, 2004 - Apr 30, 2010
      Role: Principal Investigator
      Plasticity and Regeneration in the Primate Spinal Cord
      NIH R01NS042291Sep 1, 2001 - Mar 31, 2016
      Role: Principal Investigator
      Netrins and Gene Therapy After Spinal Cord Injury
      NIH R21NS042038Jul 15, 2001 - Jun 30, 2004
      Role: Principal Investigator
      Neurobiological Aspects of Aging
      NIH K12AG000975Apr 1, 2000 - Mar 31, 2012
      Role: Principal Investigator
      EX VIVO SCHWANN CELL GENE THERAPY FOR CNS REPAIR
      NIH R01NS037083Dec 1, 1997 - Nov 30, 2001
      Role: Principal Investigator
      Gene Therapy for Alzheimer's Disease
      NIH P01AG010435Sep 30, 1991 - Mar 31, 2015
      Role: Principal Investigator
      CHOLINERGIC NEURONAL REGENERATION IN THE CNS
      NIH F32NS008200Oct 21, 1987
      Role: Principal Investigator
      UCSD Alzheimer's Disease Research Center P50
      NIH P50AG005131Sep 28, 1984 - Mar 31, 2019
      Role: Co-Investigator
      California National Primate Research Center
      NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hollis Ii ER, Kadoya K, Hirsch M, Samulski RJ, Tuszynski M. Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1. Mol Ther. 2008 Feb; 16(2):296-301. PMID: 28178539.
        View in: PubMed
      2. Gao M, Lu P, Lynam D, Bednark B, Campana WM, Sakamoto J, Tuszynski M. BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration. J Neural Eng. 2016 Oct 20; 13(6):066011. PMID: 27762235.
        View in: PubMed
      3. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 Jun 2; 534(7605):115-8. PMID: 27251287.
        View in: PubMed
      4. Kadoya K, Lu P, Nguyen K, Lee-Kubli C, Kumamaru H, Yao L, Knackert J, Poplawski G, Dulin JN, Strobl H, Takashima Y, Biane J, Conner J, Zhang SC, Tuszynski M. Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nat Med. 2016 May; 22(5):479-87. PMID: 27019328.
        View in: PubMed
      5. Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski M. Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning. Neuron. 2016 Mar 16; 89(6):1173-9. PMID: 26948893.
        View in: PubMed
      6. Wang L, Conner JM, Nagahara AH, Tuszynski M. Rehabilitation drives enhancement of neuronal structure in functionally relevant neuronal subsets. Proc Natl Acad Sci U S A. 2016 Mar 8; 113(10):2750-5. PMID: 26903653.
        View in: PubMed
      7. Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 2; 89(5):956-70. PMID: 26898779.
        View in: PubMed
      8. Lee-Kubli CA, Ingves M, Henry KW, Shiao R, Collyer E, Tuszynski M, Campana WM. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016 Apr; 278:91-104. PMID: 26808661.
        View in: PubMed
      9. Salegio EA, Bresnahan JC, Sparrey CJ, Camisa W, Fischer J, Leasure J, Buckley J, Nout-Lomas YS, Rosenzweig ES, Moseanko R, Strand S, Hawbecker S, Lemoy MJ, Haefeli J, Ma X, Nielson JL, Edgerton VR, Ferguson AR, Tuszynski M, Beattie MS. A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta). J Neurotrauma. 2016 Mar 1; 33(5):439-59. PMID: 26788611.
        View in: PubMed
      10. van Niekerk EA, Tuszynski M, Lu P, Dulin JN. Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury. Mol Cell Proteomics. 2016 Feb; 15(2):394-408. PMID: 26695766.
        View in: PubMed
      11. Brock JH, Graham L, Staufenberg E, Collyer E, Koffler J, Tuszynski M. Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury. J Neurotrauma. 2016 Jun 15; 33(12):1103-14. PMID: 26414795.
        View in: PubMed
      12. Dulin JN, Antunes-Martins A, Chandran V, Costigan M, Lerch JK, Willis DE, Tuszynski M. Transcriptomic Approaches to Neural Repair. J Neurosci. 2015 Oct 14; 35(41):13860-7. PMID: 26468186.
        View in: PubMed
      13. Tuszynski M, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct 1; 72(10):1139-47. PMID: 26302439.
        View in: PubMed
      14. Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC, Bézard E, Bloch J, Edgerton VR, Ferguson AR, Curt A, Tuszynski M, Courtine G. Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates. Sci Transl Med. 2015 Aug 26; 7(302):302ra134. PMID: 26311729.
        View in: PubMed
      15. Biane JS, Scanziani M, Tuszynski M, Conner JM. Motor Cortex Maturation Is Associated with Reductions in Recurrent Connectivity among Functional Subpopulations and Increases in Intrinsic Excitability. J Neurosci. 2015 Mar 18; 35(11):4719-28. PMID: 25788688.
        View in: PubMed
      16. Ramanathan DS, Conner JM, Anilkumar AA, Tuszynski M. Cholinergic systems are essential for late-stage maturation and refinement of motor cortical circuits. J Neurophysiol. 2015 Mar 1; 113(5):1585-97. PMID: 25505106.
        View in: PubMed
      17. Nielson JL, Haefeli J, Salegio EA, Liu AW, Guandique CF, Stück ED, Hawbecker S, Moseanko R, Strand SC, Zdunowski S, Brock JH, Roy RR, Rosenzweig ES, Nout-Lomas YS, Courtine G, Havton LA, Steward O, Reggie Edgerton V, Tuszynski M, Beattie MS, Bresnahan JC, Ferguson AR. Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury. Brain Res. 2015 Sep 4; 1619:124-38. PMID: 25451131.
        View in: PubMed
      18. Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, Goldstein LS, Tuszynski M. Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron. 2014 Aug 20; 83(4):789-96. PMID: 25123310.
        View in: PubMed
      19. Biane J, Conner JM, Tuszynski M. Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex. Front Cell Neurosci. 2014; 8:220. PMID: 25147503.
        View in: PubMed
      20. Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, Whittemore SR, McTigue DM, Popovich PG, Rabchevsky AG, Scheff SW, Steward O, Courtine G, Edgerton VR, Tuszynski M, Beattie MS, Bresnahan JC, Ferguson AR. Development of a database for translational spinal cord injury research. J Neurotrauma. 2014 Nov 1; 31(21):1789-99. PMID: 25077610.
        View in: PubMed
      21. Tuszynski M, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cells in models of spinal cord injury. Exp Neurol. 2014 Nov; 261:494-500. PMID: 25079369.
        View in: PubMed
      22. Lu P, Graham L, Wang Y, Wu D, Tuszynski M. Promotion of survival and differentiation of neural stem cells with fibrin and growth factor cocktails after severe spinal cord injury. J Vis Exp. 2014; (89). PMID: 25145787.
        View in: PubMed
      23. Lu P, Kadoya K, Tuszynski M. Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury. Curr Opin Neurobiol. 2014 Aug; 27:103-9. PMID: 24709371.
        View in: PubMed
      24. Tuszynski M, Wang Y, Graham L, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cell dissemination after grafting to CNS injury sites. Cell. 2014 Jan 30; 156(3):388-9. PMID: 24485445.
        View in: PubMed
      25. Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski M. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci. 2013 Sep 25; 33(39):15596-602. PMID: 24068826.
        View in: PubMed
      26. Do JL, Bonni A, Tuszynski M. SnoN facilitates axonal regeneration after spinal cord injury. PLoS One. 2013; 8(8):e71906. PMID: 23936531.
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      27. Yoon C, Van Niekerk EA, Henry K, Ishikawa T, Orita S, Tuszynski M, Campana WM. Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. J Biol Chem. 2013 Sep 13; 288(37):26557-68. PMID: 23867460.
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      28. Gao M, Lu P, Bednark B, Lynam D, Conner JM, Sakamoto J, Tuszynski M. Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection. Biomaterials. 2013 Feb; 34(5):1529-36. PMID: 23182350.
        View in: PubMed
      29. Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski M. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14; 150(6):1264-73. PMID: 22980985.
        View in: PubMed
      30. Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski M, Huang K. JNK3 perpetuates metabolic stress induced by Aß peptides. Neuron. 2012 Sep 6; 75(5):824-37. PMID: 22958823.
        View in: PubMed
      31. Lu P, Blesch A, Graham L, Wang Y, Samara R, Banos K, Haringer V, Havton L, Weishaupt N, Bennett D, Fouad K, Tuszynski M. Motor axonal regeneration after partial and complete spinal cord transection. J Neurosci. 2012 Jun 13; 32(24):8208-18. PMID: 22699902.
        View in: PubMed
      32. Tuszynski M, Steward O. Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012 Jun 7; 74(5):777-91. PMID: 22681683.
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      33. Nout YS, Rosenzweig ES, Brock JH, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Courtine G, Ferguson AR, Edgerton VR, Beattie MS, Bresnahan JC, Tuszynski M. Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury. Neurotherapeutics. 2012 Apr; 9(2):380-92. PMID: 22427157.
        View in: PubMed
      34. Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, Brock JH, Courtine G, Edgerton VR, Tuszynski M, Beattie MS, Bresnahan JC. Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey. Neurorehabil Neural Repair. 2012 Jul-Aug; 26(6):556-69. PMID: 22331214.
        View in: PubMed
      35. Blesch A, Fischer I, Tuszynski M. Gene therapy, neurotrophic factors and spinal cord regeneration. Handb Clin Neurol. 2012; 109:563-74. PMID: 23098737.
        View in: PubMed
      36. Yoon C, Tuszynski M. Frontiers of spinal cord and spine repair: experimental approaches for repair of spinal cord injury. Adv Exp Med Biol. 2012; 760:1-15. PMID: 23281510.
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      37. Blesch A, Lu P, Tsukada S, Alto LT, Roet K, Coppola G, Geschwind D, Tuszynski M. Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects. Exp Neurol. 2012 May; 235(1):162-73. PMID: 22227059.
        View in: PubMed
      38. Hollis ER, Tuszynski M. Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury. Neurotherapeutics. 2011 Oct; 8(4):694-703. PMID: 21904786.
        View in: PubMed
      39. Nagahara AH, Tuszynski M. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov. 2011 Mar; 10(3):209-19. PMID: 21358740.
        View in: PubMed
      40. Wang L, Conner JM, Rickert J, Tuszynski M. Structural plasticity within highly specific neuronal populations identifies a unique parcellation of motor learning in the adult brain. Proc Natl Acad Sci U S A. 2011 Feb 8; 108(6):2545-50. PMID: 21257908.
        View in: PubMed
      41. Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR, Tuszynski M. Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci. 2010 Dec; 13(12):1505-10. PMID: 21076427.
        View in: PubMed
      42. Brock JH, Rosenzweig ES, Blesch A, Moseanko R, Havton LA, Edgerton VR, Tuszynski M. Local and remote growth factor effects after primate spinal cord injury. J Neurosci. 2010 Jul 21; 30(29):9728-37. PMID: 20660255.
        View in: PubMed
      43. Gros T, Sakamoto JS, Blesch A, Havton LA, Tuszynski M. Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds. Biomaterials. 2010 Sep; 31(26):6719-29. PMID: 20619785.
        View in: PubMed
      44. Hollis ER, Jamshidi P, Lorenzana AO, Lee JK, Gray SJ, Samulski RJ, Zheng B, Tuszynski M. Transient demyelination increases the efficiency of retrograde AAV transduction. Mol Ther. 2010 Aug; 18(8):1496-500. PMID: 20502445.
        View in: PubMed
      45. Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski M. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 2009 Oct 29; 64(2):165-72. PMID: 19874785.
        View in: PubMed
      46. Conner JM, Franks KM, Titterness AK, Russell K, Merrill DA, Christie BR, Sejnowski TJ, Tuszynski M. NGF is essential for hippocampal plasticity and learning. J Neurosci. 2009 Sep 2; 29(35):10883-9. PMID: 19726646.
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      47. Alfa RW, Tuszynski M, Blesch A. A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth. J Neurosci Res. 2009 Sep; 87(12):2624-31. PMID: 19405107.
        View in: PubMed
      48. Alto LT, Havton LA, Conner JM, Hollis ER, Blesch A, Tuszynski M. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci. 2009 Sep; 12(9):1106-13. PMID: 19648914.
        View in: PubMed
      49. Ramanathan D, Tuszynski M, Conner JM. The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. J Neurosci. 2009 May 6; 29(18):5992-6000. PMID: 19420265.
        View in: PubMed
      50. Hollis ER, Jamshidi P, Löw K, Blesch A, Tuszynski M. Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7215-20. PMID: 19359495.
        View in: PubMed
      51. Merrill DA, Masliah E, Roberts JA, McKay H, Kordower JH, Mufson EJ, Tuszynski M. Association of early experience with neurodegeneration in aged primates. Neurobiol Aging. 2011 Jan; 32(1):151-6. PMID: 19321231.
        View in: PubMed
      52. Rosenzweig ES, Brock JH, Culbertson MD, Lu P, Moseanko R, Edgerton VR, Havton LA, Tuszynski M. Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys. J Comp Neurol. 2009 Mar 10; 513(2):151-63. PMID: 19125408.
        View in: PubMed
      53. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski M. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar; 15(3):331-7. PMID: 19198615.
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      54. Blesch A, Tuszynski M. Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci. 2009 Jan; 32(1):41-7. PMID: 18977039.
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      55. Nagahara AH, Bernot T, Moseanko R, Brignolo L, Blesch A, Conner JM, Ramirez A, Gasmi M, Tuszynski M. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp Neurol. 2009 Jan; 215(1):153-9. PMID: 19013154.
        View in: PubMed
      56. Hollis ER, Lu P, Blesch A, Tuszynski M. IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp Neurol. 2009 Jan; 215(1):53-9. PMID: 18938163.
        View in: PubMed
      57. Nagahara AH, Bernot T, Tuszynski M. Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery. Neurobiol Aging. 2010 Jun; 31(6):1020-31. PMID: 18760505.
        View in: PubMed
      58. Herzog CD, Dass B, Gasmi M, Bakay R, Stansell JE, Tuszynski M, Bankiewicz K, Chen EY, Chu Y, Bishop K, Kordower JH, Bartus RT. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Mol Ther. 2008 Oct; 16(10):1737-44. PMID: 18728639.
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      59. Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG, Tuszynski M, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J, Khachaturian AS, Bain LJ. A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement. 2008 May; 4(3):156-63. PMID: 18631960.
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      60. Bishop KM, Hofer EK, Mehta A, Ramirez A, Sun L, Tuszynski M, Bartus RT. Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons. Exp Neurol. 2008 Jun; 211(2):574-84. PMID: 18439998.
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      61. Löw K, Culbertson M, Bradke F, Tessier-Lavigne M, Tuszynski M. Netrin-1 is a novel myelin-associated inhibitor to axon growth. J Neurosci. 2008 Jan 30; 28(5):1099-108. PMID: 18234888.
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      62. Hollis ER, Kadoya K, Hirsch M, Samulski RJ, Tuszynski M. Efficient retrograde neuronal transduction utilizing self-complementary AAV1. Mol Ther. 2008 Feb; 16(2):296-301. PMID: 18223548.
        View in: PubMed
      63. Blesch A, Tuszynski M. Transient growth factor delivery sustains regenerated axons after spinal cord injury. J Neurosci. 2007 Sep 26; 27(39):10535-45. PMID: 17898225.
        View in: PubMed
      64. Lu P, Tuszynski M. Growth factors and combinatorial therapies for CNS regeneration. Exp Neurol. 2008 Feb; 209(2):313-20. PMID: 17927983.
        View in: PubMed
      65. Tuszynski M. Nerve growth factor gene delivery: animal models to clinical trials. Dev Neurobiol. 2007 Aug; 67(9):1204-15. PMID: 17514712.
        View in: PubMed
      66. Herzog CD, Dass B, Holden JE, Stansell J, Gasmi M, Tuszynski M, Bartus RT, Kordower JH. Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. Mov Disord. 2007 Jun 15; 22(8):1124-32. PMID: 17443702.
        View in: PubMed
      67. Tuszynski M. Nerve growth factor gene therapy in Alzheimer disease. Alzheimer Dis Assoc Disord. 2007 Apr-Jun; 21(2):179-89. PMID: 17545746.
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      68. Bartus RT, Herzog CD, Bishop K, Ostrove JM, Tuszynski M, Kordower JH, Gasmi M. Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point. Parkinsonism Relat Disord. 2007; 13 Suppl 3:S469-77. PMID: 18267286.
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      69. Blurton-Jones M, Tuszynski M. Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. J Comp Neurol. 2006 Dec 1; 499(4):603-12. PMID: 17029253.
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      70. Tuszynski M. Challenges to the report of Nogo antibody effects in primates. Nat Med. 2006 Nov; 12(11):1231-2; author reply 1232-3. PMID: 17088880.
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      71. Lu P, Yang H, Culbertson M, Graham L, Roskams AJ, Tuszynski M. Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury. J Neurosci. 2006 Oct 25; 26(43):11120-30. PMID: 17065452.
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      72. Lu P, Jones LL, Tuszynski M. Axon regeneration through scars and into sites of chronic spinal cord injury. Exp Neurol. 2007 Jan; 203(1):8-21. PMID: 17014846.
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      73. Stokols S, Sakamoto J, Breckon C, Holt T, Weiss J, Tuszynski M. Templated agarose scaffolds support linear axonal regeneration. Tissue Eng. 2006 Oct; 12(10):2777-87. PMID: 17518647.
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      74. Taylor L, Jones L, Tuszynski M, Blesch A. Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci. 2006 Sep 20; 26(38):9713-21. PMID: 16988042.
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      75. Ramanathan D, Conner JM, Tuszynski M. A form of motor cortical plasticity that correlates with recovery of function after brain injury. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11370-5. PMID: 16837575.
        View in: PubMed
      76. Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR, Tuszynski M. Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66. PMID: 16495442.
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      77. Stokols S, Tuszynski M. Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury. Biomaterials. 2006 Jan; 27(3):443-51. PMID: 16099032.
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      78. Courtine G, Roy RR, Raven J, Hodgson J, McKay H, Yang H, Zhong H, Tuszynski M, Edgerton VR. Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta). Brain. 2005 Oct; 128(Pt 10):2338-58. PMID: 16049043.
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      79. Blesch A, Conner J, Pfeifer A, Gasmi M, Ramirez A, Britton W, Alfa R, Verma I, Tuszynski M. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Mol Ther. 2005 Jun; 11(6):916-25. PMID: 15922962.
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      80. Tuszynski M, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon J, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med. 2005 May; 11(5):551-5. PMID: 15852017.
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      81. Conner JM, Chiba AA, Tuszynski M. The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury. Neuron. 2005 Apr 21; 46(2):173-9. PMID: 15848797.
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      82. Courtine G, Roy RR, Hodgson J, McKay H, Raven J, Zhong H, Yang H, Tuszynski M, Edgerton VR. Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus). J Neurophysiol. 2005 Jun; 93(6):3127-45. PMID: 15647397.
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      83. Tuszynski M. New strategies for CNS repair. Ernst Schering Res Found Workshop. 2005; (53):1-10. PMID: 16315605.
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      84. Stokols S, Tuszynski M. The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury. Biomaterials. 2004 Dec; 25(27):5839-46. PMID: 15172496.
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      85. Lu P, Blesch A, Tuszynski M. Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact? J Neurosci Res. 2004 Jul 15; 77(2):174-91. PMID: 15211585.
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      86. Lu P, Yang H, Jones LL, Filbin MT, Tuszynski M. Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci. 2004 Jul 14; 24(28):6402-9. PMID: 15254096.
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      87. Blesch A, Tuszynski M. Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury. Yonsei Med J. 2004 Jun 30; 45 Suppl:28-31. PMID: 15250047.
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      88. Lacroix S, Havton LA, McKay H, Yang H, Brant A, Roberts J, Tuszynski M. Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study. J Comp Neurol. 2004 May 24; 473(2):147-61. PMID: 15101086.
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      89. Nagahara A, Tuszynski M. The ageless question--what accounts for age-related cognitive decline? Sci Aging Knowledge Environ. 2004 May 12; 2004(19):pe20. PMID: 15141075.
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      90. Smith DE, Rapp PR, McKay HM, Roberts JA, Tuszynski M. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J Neurosci. 2004 May 5; 24(18):4373-81. PMID: 15128851.
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      91. Blesch A, Tuszynski M. Nucleus hears axon's pain. Nat Med. 2004 Mar; 10(3):236-7. PMID: 14991043.
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      92. Tuszynski M, Blesch A. Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease. Prog Brain Res. 2004; 146:441-9. PMID: 14699979.
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      93. Blesch A, Tuszynski M. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol. 2003 Dec 15; 467(3):403-17. PMID: 14608602.
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      94. Jones LL, Sajed D, Tuszynski M. Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition. J Neurosci. 2003 Oct 15; 23(28):9276-88. PMID: 14561854.
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      95. Tuszynski M. Gene therapy for neurological disease. Expert Opin Biol Ther. 2003 Aug; 3(5):815-28. PMID: 12880381.
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      96. Jones LL, Margolis RU, Tuszynski M. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol. 2003 Aug; 182(2):399-411. PMID: 12895450.
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      97. Conner JM, Culberson A, Packowski C, Chiba AA, Tuszynski M. Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron. 2003 Jun 5; 38(5):819-29. PMID: 12797965.
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      98. Tuszynski M, Grill R, Jones LL, Brant A, Blesch A, Löw K, Lacroix S, Lu P. NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Exp Neurol. 2003 May; 181(1):47-56. PMID: 12710933.
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      99. Merrill DA, Karim R, Darraq M, Chiba AA, Tuszynski M. Hippocampal cell genesis does not correlate with spatial learning ability in aged rats. J Comp Neurol. 2003 Apr 28; 459(2):201-7. PMID: 12640670.
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      100. Lacroix S, Chang L, Rose-John S, Tuszynski M. Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth. J Comp Neurol. 2002 Dec 16; 454(3):213-28. PMID: 12442313.
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      101. Tuszynski M, U HS, Alksne J, Bakay RA, Pay MM, Merrill D, Thal LJ. Growth factor gene therapy for Alzheimer disease. Neurosurg Focus. 2002 Nov 15; 13(5):e5. PMID: 15769074.
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      102. Blurton-Jones M, Tuszynski M. Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. J Comp Neurol. 2002 Oct 21; 452(3):276-87. PMID: 12353223.
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      103. Tuszynski M, Thal L, U HS, Pay MM, Blesch A, Conner J, Vahlsing HL. Nerve growth factor gene therapy for Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):207. PMID: 12212782.
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      104. Tuszynski M, Grill R, Jones LL, McKay HM, Blesch A. Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts. J Comp Neurol. 2002 Jul 15; 449(1):88-101. PMID: 12115695.
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      105. Jones LL, Tuszynski M. Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors. J Neurosci. 2002 Jun 1; 22(11):4611-24. PMID: 12040068.
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      106. Tuszynski M. Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol. 2002 May; 1(1):51-7. PMID: 12849545.
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      107. Jones LL, Yamaguchi Y, Stallcup WB, Tuszynski M. NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci. 2002 Apr 1; 22(7):2792-803. PMID: 11923444.
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      108. Blesch A, Lu P, Tuszynski M. Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull. 2002 Apr; 57(6):833-8. PMID: 12031281.
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      109. Tuszynski M, Conner J, Blesch A, Smith D, Merrill DA, Vahlsing HL. New strategies in neural repair. Prog Brain Res. 2002; 138:401-9. PMID: 12432780.
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      110. Blesch A, Tuszynski M. Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog Brain Res. 2002; 137:415-23. PMID: 12440384.
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      111. Merrill DA, Blesch A, Tuszynski M. Therapeutic potential of nervous system growth factors for neurodegenerative disease. Expert Rev Neurother. 2002 Jan; 2(1):89-96. PMID: 19811018.
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