Mark Tuszynski

Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    A Clinical Trial of AAV2-BDNF Gene Therapy in Alzheimer's Disease
    NIH R01AG071656May 15, 2021 - Apr 30, 2026
    Role: Principal Investigator
    SCI Consortium Study: 3D Printed Scaffolds for Primate Spinal Cord Injury Repair
    NIH I01RX003405Apr 1, 2021 - Mar 31, 2025
    Role: Co-Principal Investigator
    Improved Intrathecal BDNF Gene Therapy for Alzheimer's Disease
    NIH R01AG066080Apr 15, 2020 - Feb 28, 2025
    Role: Principal Investigator
    3D Printed Scaffolds for Primate Spinal Cord Injury Repair
    NIH R01NS114043Jan 1, 2020 - Dec 31, 2022
    Role: Principal Investigator
    ShEEP request for a Zeiss LSM 880 with Airyscan confocal system
    NIH IS1BX004001Jan 1, 2018 - Sep 30, 2018
    Role: Principal Investigator
    Embryonic stem cell therapy after cervical contusion SCI in NHPs
    NIH R01NS105478Sep 25, 2017 - Jun 30, 2022
    Role: Co-Principal Investigator
    3D Printed Scaffolds for Primate Spinal Cord Injury
    NIH R03NS104972Sep 22, 2017 - Aug 31, 2019
    Role: Principal Investigator
    The Primate Corticospinal Connectome and Transcriptome
    NIH R01NS104442Sep 15, 2017 - May 31, 2026
    Role: Principal Investigator
    RR&D Gordon Mansfield Spinal Cord Injury Consortium
    NIH I50RX001706Jul 1, 2015 - Dec 31, 2025
    Role: Principal Investigator
    Acquisition of a Keyence BZ-X700 All-In-One Automated Imaging System
    NIH IS1BX003125Jan 1, 2015 - Sep 30, 2015
    Role: Principal Investigator
    A Translational Program of BDNF Gene Delivery in Alzheimer's Disease
    NIH U01AG043416Jun 15, 2014 - May 31, 2021
    Role: Principal Investigator
    Bioengineered Scaffolds for Spinal Cord Injury
    NIH R01EB014986May 15, 2012 - Apr 30, 2018
    Role: Principal Investigator
    Contusive Spinal Cord Injury Model Development
    NIH I01RX000434Oct 1, 2010 - Sep 30, 2012
    Role: Principal Investigator
    Combinatorial Approaches to SCI
    NIH R01NS049881Aug 3, 2004 - Apr 30, 2010
    Role: Principal Investigator
    Plasticity and Regeneration in the Primate Spinal Cord
    NIH R56NS042291Sep 1, 2001 - Mar 31, 2018
    Role: Principal Investigator
    Plasticity and Regeneration in the Primate Spinal Cord
    NIH R01NS042291Sep 1, 2001 - Mar 31, 2017
    Role: Principal Investigator
    Netrins and Gene Therapy After Spinal Cord Injury
    NIH R21NS042038Jul 15, 2001 - Jun 30, 2004
    Role: Principal Investigator
    Neurobiological Aspects of Aging
    NIH K12AG000975Apr 1, 2000 - Mar 31, 2012
    Role: Principal Investigator
    EX VIVO SCHWANN CELL GENE THERAPY FOR CNS REPAIR
    NIH R01NS037083Dec 1, 1997 - Nov 30, 2001
    Role: Principal Investigator
    Gene Therapy for Alzheimer's Disease
    NIH P01AG010435Sep 30, 1991 - Mar 31, 2016
    Role: Principal Investigator
    CHOLINERGIC NEURONAL REGENERATION IN THE CNS
    NIH F32NS008200Oct 21, 1987
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH P50AG005131Sep 28, 1984 - Mar 31, 2020
    Role: Co-Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Selective plasticity of layer 2/3 inputs onto distal forelimb controlling layer 5 corticospinal neurons with skilled grasp motor training. Cell Rep. 2024 Apr 09; 43(4):113986. Takashima Y, Biane JS, Tuszynski MH. PMID: 38598336.
      View in: PubMed   Mentions:
    2. Emergence of functionally aberrant and subsequent reduction of neuromuscular connectivity and improved motor performance after cervical spinal cord injury in Rhesus. Front Rehabil Sci. 2023; 4:1205456. Wai G, Zdunowski S, Zhong H, Nielson JL, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Nout-Lomas YS, Rosenzweig ES, Beattie MS, Bresnahan JC, Tuszynski MH, Roy RR, Edgerton VR. PMID: 37378049; PMCID: PMC10291623.
      View in: PubMed   Mentions:
    3. Regulation of axonal regeneration after mammalian spinal cord injury. Nat Rev Mol Cell Biol. 2023 06; 24(6):396-413. Zheng B, Tuszynski MH. PMID: 36604586.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    4. BDNF guides neural stem cell-derived axons to ventral interneurons and motor neurons after spinal cord injury. Exp Neurol. 2023 Jan; 359:114259. Li Y, Tran A, Graham L, Brock J, Tuszynski MH, Lu P. PMID: 36309123.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury. JCI Insight. 2022 08 22; 7(16). Lu P, Freria CM, Graham L, Tran AN, Villarta A, Yassin D, Huie JR, Ferguson AR, Tuszynski MH. PMID: 35993363; PMCID: PMC9462483.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    6. Rhesus macaque versus rat divergence in the corticospinal projectome. Neuron. 2022 09 21; 110(18):2970-2983.e4. Sinopoulou E, Rosenzweig ES, Conner JM, Gibbs D, Weinholtz CA, Weber JL, Brock JH, Nout-Lomas YS, Ovruchesky E, Takashima Y, Biane JS, Kumamaru H, Havton LA, Beattie MS, Bresnahan JC, Tuszynski MH. PMID: 35917818; PMCID: PMC9509478.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    7. Methods for culturing adult CNS neurons reveal a CNS conditioning effect. Cell Rep Methods. 2022 07 18; 2(7):100255. van Niekerk EA, Kawaguchi R, Marques de Freria C, Groeniger K, Marchetto MC, Dupraz S, Bradke F, Geschwind DH, Gage FH, Tuszynski MH. PMID: 35880023; PMCID: PMC9308166.
      View in: PubMed   Mentions: 3  Translation:HumansCells
    8. Quantifying the kinematic features of dexterous finger movements in nonhuman primates with markerless tracking. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:6110-6115. North R, Wurr R, Macon R, Mannion C, Hyde J, Torres-Espin A, Rosenzweig ES, Ferguson AR, Tuszynski MH, Beattie MS, Bresnahan JC, Joiner WM. PMID: 34892511.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    9. Optic Nerve Engraftment of Neural Stem Cells. Invest Ophthalmol Vis Sci. 2021 07 01; 62(9):30. Do JL, Allahwerdy S, David RCC, Weinreb RN, Tuszynski MH, Welsbie DS. PMID: 34283208; PMCID: PMC8300061.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Experimental Treatments for Spinal Cord Injury: What you Should Know. Top Spinal Cord Inj Rehabil. 2021 Spring; 27(2):50-74. Failli V, Kleitman N, Lammertse DP, Hsieh JTC, Steeves JD, Fawcett JW, Tuszynski MH, Curt A, Fehlings MG, Guest JD, Blight AR. PMID: 34108834; PMCID: PMC8152172.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    11. Regeneration of Corticospinal Axons into Neural Progenitor Cell Grafts After Spinal Cord Injury. Neurosci Insights. 2020; 15:2633105520974000. Poplawski GH, Tuszynski MH. PMID: 33283187; PMCID: PMC7691939.
      View in: PubMed   Mentions:
    12. Sexual dimorphism of detrusor function demonstrated by urodynamic studies in rhesus macaques. Sci Rep. 2020 09 30; 10(1):16170. Biscola NP, Christe KL, Rosenzweig ES, Tuszynski MH, Havton LA. PMID: 32999325; PMCID: PMC7527962.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury. Cell Stem Cell. 2020 09 03; 27(3):430-440.e5. Ceto S, Sekiguchi KJ, Takashima Y, Nimmerjahn A, Tuszynski MH. PMID: 32758426; PMCID: PMC7484050.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    14. Injured adult neurons regress to an embryonic transcriptional growth state. Nature. 2020 05; 581(7806):77-82. Poplawski GHD, Kawaguchi R, Van Niekerk E, Lu P, Mehta N, Canete P, Lie R, Dragatsis I, Meves JM, Zheng B, Coppola G, Tuszynski MH. PMID: 32376949.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    15. Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery. Hum Gene Ther. 2020 04; 31(7-8):415-422. Castle MJ, Baltanás FC, Kovacs I, Nagahara AH, Barba D, Tuszynski MH. PMID: 32126838; PMCID: PMC7194314.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCellsCTClinical Trials
    16. Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury. Nat Neurosci. 2019 08; 22(8):1269-1275. Rosenzweig ES, Salegio EA, Liang JJ, Weber JL, Weinholtz CA, Brock JH, Moseanko R, Hawbecker S, Pender R, Cruzen CL, Iaci JF, Caggiano AO, Blight AR, Haenzi B, Huie JR, Havton LA, Nout-Lomas YS, Fawcett JW, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH. PMID: 31235933; PMCID: PMC6693679.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    17. Origins of Neural Progenitor Cell-Derived Axons Projecting Caudally after Spinal Cord Injury. Stem Cell Reports. 2019 07 09; 13(1):105-114. Lu P, Gomes-Leal W, Anil S, Dobkins G, Huie JR, Ferguson AR, Graham L, Tuszynski M. PMID: 31204300; PMCID: PMC6626851.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. Reorganization of Recurrent Layer 5 Corticospinal Networks Following Adult Motor Training. J Neurosci. 2019 06 12; 39(24):4684-4693. Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski MH. PMID: 30948479; PMCID: PMC6561695.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    19. Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts. Cell Rep. 2019 02 26; 26(9):2329-2339.e4. Kumamaru H, Lu P, Rosenzweig ES, Kadoya K, Tuszynski MH. PMID: 30811984; PMCID: PMC6487864.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    20. Astrocytes migrate from human neural stem cell grafts and functionally integrate into the injured rat spinal cord. Exp Neurol. 2019 04; 314:46-57. Lien BV, Tuszynski MH, Lu P. PMID: 30653967.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    21. Biomimetic 3D-printed scaffolds for spinal cord injury repair. Nat Med. 2019 02; 25(2):263-269. Koffler J, Zhu W, Qu X, Platoshyn O, Dulin JN, Brock J, Graham L, Lu P, Sakamoto J, Marsala M, Chen S, Tuszynski MH. PMID: 30643285; PMCID: PMC6559945.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    22. Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion. Sci Adv. 2018 11; 4(11):eaau9859. Castle MJ, Cheng Y, Asokan A, Tuszynski MH. PMID: 30443600; PMCID: PMC6235539.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Activation of Intrinsic Growth State Enhances Host Axonal Regeneration into Neural Progenitor Cell Grafts. Stem Cell Reports. 2018 10 09; 11(4):861-868. Kumamaru H, Lu P, Rosenzweig ES, Tuszynski MH. PMID: 30197116; PMCID: PMC6178188.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    24. Generation and post-injury integration of human spinal cord neural stem cells. Nat Methods. 2018 09; 15(9):723-731. Kumamaru H, Kadoya K, Adler AF, Takashima Y, Graham L, Coppola G, Tuszynski MH. PMID: 30082899.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    25. Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 07 01; 75(7):834-841. Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA, Siffert J, Aisen PS, AAV2-NGF Study Team. PMID: 29582053; PMCID: PMC5885277.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    26. Adult rat myelin enhances axonal outgrowth from neural stem cells. Sci Transl Med. 2018 05 23; 10(442). Poplawski GHD, Lie R, Hunt M, Kumamaru H, Kawaguchi R, Lu P, Schäfer MKE, Woodruff G, Robinson J, Canete P, Dulin JN, Geoffroy CG, Menzel L, Zheng B, Coppola G, Tuszynski MH. PMID: 29794059; PMCID: PMC8377986.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. Microstructure and in vivo characterization of multi-channel nerve guidance scaffolds. Biomed Mater. 2018 04 25; 13(4):044104. Pawelec KM, Koffler J, Shahriari D, Galvan A, Tuszynski MH, Sakamoto J. PMID: 29411711.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    28. MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates. Gene Ther. 2018 04; 25(2):104-114. Nagahara AH, Wilson BR, Ivasyk I, Kovacs I, Rawalji S, Bringas JR, Pivirotto PJ, Sebastian WS, Samaranch L, Bankiewicz KS, Tuszynski MH. PMID: 29535375; PMCID: PMC5924461.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    29. Rodent Neural Progenitor Cells Support Functional Recovery after Cervical Spinal Cord Contusion. J Neurotrauma. 2018 05 01; 35(9):1069-1078. Brock JH, Graham L, Staufenberg E, Im S, Tuszynski MH. PMID: 29279015; PMCID: PMC5908429.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    30. Restorative effects of human neural stem cell grafts on the primate spinal cord. Nat Med. 2018 05; 24(4):484-490. Rosenzweig ES, Brock JH, Lu P, Kumamaru H, Salegio EA, Kadoya K, Weber JL, Liang JJ, Moseanko R, Hawbecker S, Huie JR, Havton LA, Nout-Lomas YS, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH. PMID: 29480894; PMCID: PMC5922761.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    31. Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization. Adv Mater. 2018 Mar; 30(12):e1706785. Zuidema JM, Kumeria T, Kim D, Kang J, Wang J, Hollett G, Zhang X, Roberts DS, Chan N, Dowling C, Blanco-Suarez E, Allen NJ, Tuszynski MH, Sailor MJ. PMID: 29363828; PMCID: PMC6475500.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    32. Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. Nat Commun. 2018 01 08; 9(1):84. Dulin JN, Adler AF, Kumamaru H, Poplawski GHD, Lee-Kubli C, Strobl H, Gibbs D, Kadoya K, Fawcett JW, Lu P, Tuszynski MH. PMID: 29311559; PMCID: PMC5758751.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    33. Enhanced axonal transport: A novel form of "plasticity" after primate and rodent spinal cord injury. Exp Neurol. 2018 03; 301(Pt A):59-69. Brock JH, Rosenzweig ES, Yang H, Tuszynski MH. PMID: 29277625; PMCID: PMC7291621.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    34. Peripheral nerve growth within a hydrogel microchannel scaffold supported by a kink-resistant conduit. J Biomed Mater Res A. 2017 Dec; 105(12):3392-3399. Shahriari D, Shibayama M, Lynam DA, Wolf KJ, Kubota G, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. PMID: 28804998; PMCID: PMC6611669.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    35. Prolonged human neural stem cell maturation supports recovery in injured rodent CNS. J Clin Invest. 2017 Sep 01; 127(9):3287-3299. Lu P, Ceto S, Wang Y, Graham L, Wu D, Kumamaru H, Staufenberg E, Tuszynski MH. PMID: 28825600; PMCID: PMC5669577.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    36. Myelination of axons emerging from neural progenitor grafts after spinal cord injury. Exp Neurol. 2017 10; 296:69-73. Hunt M, Lu P, Tuszynski MH. PMID: 28698030.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    37. Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury. Stem Cell Reports. 2017 06 06; 8(6):1525-1533. Adler AF, Lee-Kubli C, Kumamaru H, Kadoya K, Tuszynski MH. PMID: 28479302; PMCID: PMC5469919.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    38. Introduction to neuroscience letters special issue: "Plasticity and regeneration after spinal cord injury". Neurosci Lett. 2017 06 23; 652:1-2. Lu P, Tuszynski MH. PMID: 28432027.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    39. Hierarchically Ordered Porous and High-Volume Polycaprolactone Microchannel Scaffolds Enhanced Axon Growth in Transected Spinal Cords. Tissue Eng Part A. 2017 05; 23(9-10):415-425. Shahriari D, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. PMID: 28107810; PMCID: PMC5444512.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    40. Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1. Mol Ther. 2008 Feb; 16(2):296-301. Hollis Ii ER, Kadoya K, Hirsch M, Samulski RJ, Tuszynski MH. PMID: 28178539.
      View in: PubMed   Mentions: 6     Fields:    
    41. BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration. J Neural Eng. 2016 12; 13(6):066011. Gao M, Lu P, Lynam D, Bednark B, Campana WM, Sakamoto J, Tuszynski M. PMID: 27762235.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    42. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 06 02; 534(7605):115-8. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. PMID: 27251287; PMCID: PMC5063500.
      View in: PubMed   Mentions: 375     Fields:    Translation:AnimalsCells
    43. Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nat Med. 2016 05; 22(5):479-87. Kadoya K, Lu P, Nguyen K, Lee-Kubli C, Kumamaru H, Yao L, Knackert J, Poplawski G, Dulin JN, Strobl H, Takashima Y, Biane J, Conner J, Zhang SC, Tuszynski MH. PMID: 27019328; PMCID: PMC4860037.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    44. Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning. Neuron. 2016 Mar 16; 89(6):1173-1179. Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski MH. PMID: 26948893; PMCID: PMC4795975.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    45. Rehabilitation drives enhancement of neuronal structure in functionally relevant neuronal subsets. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2750-5. Wang L, Conner JM, Nagahara AH, Tuszynski MH. PMID: 26903653; PMCID: PMC4790976.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    46. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 02; 89(5):956-70. Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. PMID: 26898779; PMCID: PMC4790095.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    47. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016 Apr; 278:91-104. Lee-Kubli CA, Ingves M, Henry KW, Shiao R, Collyer E, Tuszynski MH, Campana WM. PMID: 26808661.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    48. A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta). J Neurotrauma. 2016 Mar 01; 33(5):439-59. Salegio EA, Bresnahan JC, Sparrey CJ, Camisa W, Fischer J, Leasure J, Buckley J, Nout-Lomas YS, Rosenzweig ES, Moseanko R, Strand S, Hawbecker S, Lemoy MJ, Haefeli J, Ma X, Nielson JL, Edgerton VR, Ferguson AR, Tuszynski MH, Beattie MS. PMID: 26788611; PMCID: PMC4799702.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    49. Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury. Mol Cell Proteomics. 2016 Feb; 15(2):394-408. van Niekerk EA, Tuszynski MH, Lu P, Dulin JN. PMID: 26695766; PMCID: PMC4739663.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    50. Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury. J Neurotrauma. 2016 06 15; 33(12):1103-14. Brock JH, Graham L, Staufenberg E, Collyer E, Koffler J, Tuszynski MH. PMID: 26414795; PMCID: PMC4904236.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    51. Characterizing the degradation of alginate hydrogel for use in multilumen scaffolds for spinal cord repair. J Biomed Mater Res A. 2016 03; 104(3):611-619. Shahriari D, Koffler J, Lynam DA, Tuszynski MH, Sakamoto JS. PMID: 26488452.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    52. Transcriptomic Approaches to Neural Repair. J Neurosci. 2015 Oct 14; 35(41):13860-7. Dulin JN, Antunes-Martins A, Chandran V, Costigan M, Lerch JK, Willis DE, Tuszynski MH. PMID: 26468186; PMCID: PMC4604224.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    53. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct; 72(10):1139-47. Tuszynski MH, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. PMID: 26302439; PMCID: PMC4944824.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCellsCTClinical Trials
    54. Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates. Sci Transl Med. 2015 Aug 26; 7(302):302ra134. Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC, Bézard E, Bloch J, Edgerton VR, Ferguson AR, Curt A, Tuszynski MH, Courtine G. PMID: 26311729; PMCID: PMC5669362.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    55. Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability. J Neurosci. 2015 Mar 18; 35(11):4719-28. Biane JS, Scanziani M, Tuszynski MH, Conner JM. PMID: 25788688; PMCID: PMC4363396.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
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    123. Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. J Comp Neurol. 2006 Dec 01; 499(4):603-12. Blurton-Jones M, Tuszynski MH. PMID: 17029253.
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    124. Challenges to the report of Nogo antibody effects in primates. Nat Med. 2006 Nov; 12(11):1231-2; author reply 1232-3. Tuszynski M. PMID: 17088880.
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    125. Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury. J Neurosci. 2006 Oct 25; 26(43):11120-30. Lu P, Yang H, Culbertson M, Graham L, Roskams AJ, Tuszynski MH. PMID: 17065452; PMCID: PMC6674649.
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    126. Axon regeneration through scars and into sites of chronic spinal cord injury. Exp Neurol. 2007 Jan; 203(1):8-21. Lu P, Jones LL, Tuszynski MH. PMID: 17014846.
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    127. Templated agarose scaffolds support linear axonal regeneration. Tissue Eng. 2006 Oct; 12(10):2777-87. Stokols S, Sakamoto J, Breckon C, Holt T, Weiss J, Tuszynski MH. PMID: 17518647.
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    128. Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci. 2006 Sep 20; 26(38):9713-21. Taylor L, Jones L, Tuszynski MH, Blesch A. PMID: 16988042; PMCID: PMC6674461.
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    129. A form of motor cortical plasticity that correlates with recovery of function after brain injury. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11370-5. Ramanathan D, Conner JM, Tuszynski MH. PMID: 16837575; PMCID: PMC1544093.
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    130. Clinical trials in spinal cord injury. J Neurotrauma. 2006 Mar-Apr; 23(3-4):586-93. Blight AR, Tuszynski MH. PMID: 16629639.
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    131. Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66. Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR, Tuszynski MH. PMID: 16495442; PMCID: PMC6674802.
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    132. Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury. Biomaterials. 2006 Jan; 27(3):443-51. Stokols S, Tuszynski MH. PMID: 16099032.
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    133. Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord. 2005 Aug; 43(8):453-8. Anderson DK, Beattie M, Blesch A, Bresnahan J, Bunge M, Dietrich D, Dietz V, Dobkin B, Fawcett J, Fehlings M, Fischer I, Grossman R, Guest J, Hagg T, Hall ED, Houle J, Kleitman N, McDonald J, Murray M, Privat A, Reier P, Steeves J, Steward O, Tetzlaff W, Tuszynski MH, Waxman SG, Whittemore S, Wolpaw J, Young W, Zheng B. PMID: 15824756.
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    134. Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta). Brain. 2005 Oct; 128(Pt 10):2338-58. Courtine G, Roy RR, Raven J, Hodgson J, McKay H, Yang H, Zhong H, Tuszynski MH, Edgerton VR. PMID: 16049043.
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    135. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Mol Ther. 2005 Jun; 11(6):916-25. Blesch A, Conner J, Pfeifer A, Gasmi M, Ramirez A, Britton W, Alfa R, Verma I, Tuszynski MH. PMID: 15922962.
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    136. Can bone marrow-derived stem cells differentiate into functional neurons? Exp Neurol. 2005 Jun; 193(2):273-8. Lu P, Tuszynski MH. PMID: 15869931.
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    137. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med. 2005 May; 11(5):551-5. Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon J, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J. PMID: 15852017.
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    138. The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury. Neuron. 2005 Apr 21; 46(2):173-9. Conner JM, Chiba AA, Tuszynski MH. PMID: 15848797.
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    139. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol. 2005 Feb; 191(2):344-60. Lu P, Jones LL, Tuszynski MH. PMID: 15649491.
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    140. Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus). J Neurophysiol. 2005 Jun; 93(6):3127-45. Courtine G, Roy RR, Hodgson J, McKay H, Raven J, Zhong H, Yang H, Tuszynski MH, Edgerton VR. PMID: 15647397.
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    141. New strategies for CNS repair. Ernst Schering Res Found Workshop. 2005; (53):1-10. Tuszynski MH. PMID: 16315605.
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    142. The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury. Biomaterials. 2004 Dec; 25(27):5839-46. Stokols S, Tuszynski MH. PMID: 15172496.
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    143. Report of international clinical trials workshop on spinal cord injury February 20-21, 2004, Vancouver, Canada. Spinal Cord. 2004 Oct; 42(10):591-7. Steeves J, Fawcett J, Tuszynski M. PMID: 15303119.
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    144. Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact? J Neurosci Res. 2004 Jul 15; 77(2):174-91. Lu P, Blesch A, Tuszynski MH. PMID: 15211585.
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    145. Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci. 2004 Jul 14; 24(28):6402-9. Lu P, Yang H, Jones LL, Filbin MT, Tuszynski MH. PMID: 15254096; PMCID: PMC6729552.
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    146. Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury. Yonsei Med J. 2004 Jun 30; 45 Suppl:28-31. Blesch A, Tuszynski MH. PMID: 15250047.
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    147. Stem cells: cross-talk and developmental programs. Philos Trans R Soc Lond B Biol Sci. 2004 May 29; 359(1445):823-37. Imitola J, Park KI, Teng YD, Nisim S, Lachyankar M, Ourednik J, Mueller FJ, Yiou R, Atala A, Sidman RL, Tuszynski M, Khoury SJ, Snyder EY. PMID: 15293810; PMCID: PMC1693371.
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    148. Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study. J Comp Neurol. 2004 May 24; 473(2):147-61. Lacroix S, Havton LA, McKay H, Yang H, Brant A, Roberts J, Tuszynski MH. PMID: 15101086.
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    149. The ageless question--what accounts for age-related cognitive decline? Sci Aging Knowledge Environ. 2004 May 12; 2004(19):pe20. Nagahara A, Tuszynski MH. PMID: 15141075.
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    150. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J Neurosci. 2004 May 05; 24(18):4373-81. Smith DE, Rapp PR, McKay HM, Roberts JA, Tuszynski MH. PMID: 15128851; PMCID: PMC6729447.
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    151. Nucleus hears axon's pain. Nat Med. 2004 Mar; 10(3):236-7. Blesch A, Tuszynski MH. PMID: 14991043.
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    152. Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression. J Comp Neurol. 2004 Jan 12; 468(3):347-60. Blurton-Jones M, Kuan PN, Tuszynski MH. PMID: 14681930.
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    153. Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease. Prog Brain Res. 2004; 146:441-9. Tuszynski MH, Blesch A. PMID: 14699979.
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    154. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol. 2003 Dec 15; 467(3):403-17. Blesch A, Tuszynski MH. PMID: 14608602.
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    155. Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. Exp Neurol. 2003 Nov; 184(1):97-113. Tobias CA, Shumsky JS, Shibata M, Tuszynski MH, Fischer I, Tessler A, Murray M. PMID: 14637084.
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    156. Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition. J Neurosci. 2003 Oct 15; 23(28):9276-88. Jones LL, Sajed D, Tuszynski MH. PMID: 14561854; PMCID: PMC6740563.
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    157. Gene therapy for neurological disease. Expert Opin Biol Ther. 2003 Aug; 3(5):815-28. Tuszynski MH. PMID: 12880381.
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    158. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol. 2003 Aug; 182(2):399-411. Jones LL, Margolis RU, Tuszynski MH. PMID: 12895450.
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    159. Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron. 2003 Jun 05; 38(5):819-29. Conner JM, Culberson A, Packowski C, Chiba AA, Tuszynski MH. PMID: 12797965.
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    160. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol. 2003 Jun; 181(2):115-29. Lu P, Jones LL, Snyder EY, Tuszynski MH. PMID: 12781986.
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    161. NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Exp Neurol. 2003 May; 181(1):47-56. Tuszynski MH, Grill R, Jones LL, Brant A, Blesch A, Löw K, Lacroix S, Lu P. PMID: 12710933.
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    162. Hippocampal cell genesis does not correlate with spatial learning ability in aged rats. J Comp Neurol. 2003 Apr 28; 459(2):201-7. Merrill DA, Karim R, Darraq M, Chiba AA, Tuszynski MH. PMID: 12640670.
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    163. Growth factor gene therapy for Alzheimer disease. Neurosurg Focus. 2002 Nov 15; 13(5):e5. Tuszynski MH, U HS, Alksne J, Bakay RA, Pay MM, Merrill D, Thal LJ. PMID: 15769074.
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    164. Nerve growth factor gene therapy for Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):207. Tuszynski MH, Thal L, U HS, Pay MM, Blesch A, Conner J, Vahlsing HL. PMID: 12212782.
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    165. Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts. J Comp Neurol. 2002 Jul 15; 449(1):88-101. Tuszynski MH, Grill R, Jones LL, McKay HM, Blesch A. PMID: 12115695.
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    166. Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors. J Neurosci. 2002 Jun 01; 22(11):4611-24. Jones LL, Tuszynski MH. PMID: 12040068; PMCID: PMC6758783.
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    167. Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol. 2002 May; 1(1):51-7. Tuszynski MH. PMID: 12849545.
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    168. Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull. 2002 Apr; 57(6):833-8. Blesch A, Lu P, Tuszynski MH. PMID: 12031281.
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    169. NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci. 2002 Apr 01; 22(7):2792-803. Jones LL, Yamaguchi Y, Stallcup WB, Tuszynski MH. PMID: 11923444; PMCID: PMC6758310.
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    170. Therapeutic potential of nervous system growth factors for neurodegenerative disease. Expert Rev Neurother. 2002 Jan; 2(1):89-96. Merrill DA, Blesch A, Tuszynski MH. PMID: 19811018.
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    171. Spontaneous plasticity in the injured spinal cord-implications for repair strategies. Mol Psychiatry. 2002; 7(1):9-11. Weidner N, Tuszynski MH. PMID: 11803438.
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    172. Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats. J Comp Neurol. 2001 Oct 01; 438(4):445-56. Merrill DA, Chiba AA, Tuszynski MH. PMID: 11559900.
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    173. GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection. J Comp Neurol. 2001 Aug 06; 436(4):399-410. Blesch A, Tuszynski MH. PMID: 11447585.
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    174. Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons. J Comp Neurol. 2001 Aug 06; 436(4):456-70. Lu P, Blesch A, Tuszynski MH. PMID: 11447589.
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    175. Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expression. Gene Ther. 2001 Jun; 8(12):954-60. Blesch A, Conner JM, Tuszynski MH. PMID: 11426336.
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    176. Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. J Physiol. 2001 May 15; 533(Pt 1):83-9. Jones LL, Oudega M, Bunge MB, Tuszynski MH. PMID: 11351016; PMCID: PMC2278599.
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    177. Reactive astrocytes express estrogen receptors in the injured primate brain. J Comp Neurol. 2001 Apr 23; 433(1):115-23. Blurton-Jones M, Tuszynski MH. PMID: 11283953.
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    178. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3513-8. Weidner N, Ner A, Salimi N, Tuszynski MH. PMID: 11248109; PMCID: PMC30684.
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    179. Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1941-6. Conner JM, Darracq MA, Roberts J, Tuszynski MH. PMID: 11172055; PMCID: PMC29361.
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    180. Continuous intrathecal fluid infusions elevate nerve growth factor levels and prevent functional deficits after spinal cord ischemia. Brain Res. 2000 Nov 17; 883(2):178-83. Bowes M, Tuszynski MH, Conner J, Zivin JA. PMID: 11074046.
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    181. Intraparenchymal NGF infusions rescue degenerating cholinergic neurons. Cell Transplant. 2000 Sep-Oct; 9(5):629-36. Tuszynski MH. PMID: 11144960.
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    182. Proceedings of the Meeting of the American Society for Neural Transplantation and Repair (ASNTR), 1999. Cell Transplant. 2000 Sep; 9(5):565-566. Tuszynski MH. PMID: 28880660.
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    183. Conservation of neuron number and size in entorhinal cortex layers II, III, and V/VI of aged primates. J Comp Neurol. 2000 Jul 03; 422(3):396-401. Merrill DA, Roberts JA, Tuszynski MH. PMID: 10861515.
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    184. Neurite outgrowth can be modulated in vitro using a tetracycline-repressible gene therapy vector expressing human nerve growth factor. J Neurosci Res. 2000 Feb 01; 59(3):402-9. Blesch A, Uy HS, Diergardt N, Tuszynski MH. PMID: 10679776.
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    185. Elimination of basal lamina and the collagen "scar" after spinal cord injury fails to augment corticospinal tract regeneration. Exp Neurol. 1999 Nov; 160(1):40-50. Weidner N, Grill RJ, Tuszynski MH. PMID: 10630189.
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    186. Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1. J Comp Neurol. 1999 Nov 01; 413(4):495-506. Weidner N, Blesch A, Grill RJ, Tuszynski MH. PMID: 10495438.
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    187. Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10893-8. Smith DE, Roberts J, Gage FH, Tuszynski MH. PMID: 10485922; PMCID: PMC17979.
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    188. Human spinal cord retains substantial structural mass in chronic stages after injury. J Neurotrauma. 1999 Jun; 16(6):523-31. Tuszynski MH, Gabriel K, Gerhardt K, Szollar S. PMID: 10391368.
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    189. Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury. J Neurosci. 1999 May 01; 19(9):3556-66. Blesch A, Uy HS, Grill RJ, Cheng JG, Patterson PH, Tuszynski MH. PMID: 10212315; PMCID: PMC6782234.
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    190. Estrogen receptor immunoreactivity in the adult primate brain: neuronal distribution and association with p75, trkA, and choline acetyltransferase. J Comp Neurol. 1999 Mar 22; 405(4):529-42. Blurton-Jones MM, Roberts JA, Tuszynski MH. PMID: 10098943.
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    191. Recovery of locomotion after experimental spinal cord injury: axonal regeneration or modulation of intrinsic spinal cord walking circuitry? J Spinal Cord Med. 1999; 22(2):143. Tuszynski M, Edgerton R, Dobkin B. PMID: 10826273.
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    192. Targeted intraparenchymal delivery of human NGF by gene transfer to the primate basal forebrain for 3 months does not accelerate beta-amyloid plaque deposition. Exp Neurol. 1998 Dec; 154(2):573-82. Tuszynski MH, Smith DE, Roberts J, McKay H, Mufson E. PMID: 9878192.
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    193. Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination. Cell Transplant. 1998 Mar-Apr; 7(2):187-96. Tuszynski MH, Weidner N, McCormack M, Miller I, Powell H, Conner J. PMID: 9588600.
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    194. Neurotrophin gene therapy in CNS models of trauma and degeneration. Prog Brain Res. 1998; 117:473-84. Blesch A, Grill RJ, Tuszynski MH. PMID: 9932426.
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    195. Gene therapy for nervous system disease. Ann N Y Acad Sci. 1997 Dec 19; 835:1-11. Tuszynski MH. PMID: 9616757.
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    196. Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. Exp Neurol. 1997 Dec; 148(2):444-52. Grill RJ, Blesch A, Tuszynski MH. PMID: 9417824.
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    197. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci. 1997 Jul 15; 17(14):5560-72. Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH. PMID: 9204937; PMCID: PMC6793805.
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    198. Cerebral glucose metabolism and memory in aged rhesus macaques. Neurobiol Aging. 1997 Jul-Aug; 18(4):437-43. Eberling JL, Roberts JA, Rapp PR, Tuszynski MH, Jagust WJ. PMID: 9330976.
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    199. Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord. Cell Transplant. 1997 May-Jun; 6(3):361-8. Tuszynski MH, Murai K, Blesch A, Grill R, Miller I. PMID: 9171168.
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    200. Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor. Ann Neurol. 1997 Jan; 41(1):82-93. Winkler J, Ramirez GA, Kuhn HG, Peterson DA, Day-Lollini PA, Stewart GR, Tuszynski MH, Gage FH, Thal LJ. PMID: 9005869.
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    201. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology. 1996 Sep; 47(3):705-11. Thal LJ, Carta A, Clarke WR, Ferris SH, Friedland RP, Petersen RC, Pettegrew JW, Pfeiffer E, Raskind MA, Sano M, Tuszynski MH, Woolson RF. PMID: 8797468.
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    202. Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther. 1996 Apr; 3(4):305-14. Tuszynski MH, Roberts J, Senut MC, U HS, Gage FH. PMID: 8732162.
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    203. Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons. Neuroscience. 1996 Apr; 71(3):761-71. Tuszynski MH, Mafong E, Meyer S. PMID: 8867048.
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    204. Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplant. 1996 Mar-Apr; 5(2):191-204. Nakahara Y, Gage FH, Tuszynski MH. PMID: 8689031.
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    205. Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp Neurol. 1996 Jan; 137(1):157-73. Tuszynski MH, Gabriel K, Gage FH, Suhr S, Meyer S, Rosetti A. PMID: 8566208.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    206. Somatic gene therapy for nervous system disease. Ciba Found Symp. 1996; 196:85-94; discussion 94-7. Tuszynski MH, Gage FH. PMID: 8866129.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    207. Regional differences in responsiveness of adult CNS axons to grafts of cells expressing human neurotrophin 3. Exp Neurol. 1995 Sep; 135(1):36-55. Senut MC, Tuszynski MH, Raymon HK, Suhr ST, Liou NH, Jones KR, Reichardt LF, Gage FH. PMID: 7556552.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    208. Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4621-5. Tuszynski MH, Gage FH. PMID: 7753852; PMCID: PMC41996.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    209. Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy. Mol Neurobiol. 1995 Apr-Jun; 10(2-3):151-67. Tuszynski MH, Gage FH. PMID: 7576305.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    210. Ex vivo gene therapy for Alzheimer's disease and spinal cord injury. Clin Neurosci. 1995-1996; 3(5):268-74. Blesch A, Tuszynski M. PMID: 8914793.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    211. Somatic gene transfer to the adult primate central nervous system: in vitro and in vivo characterization of cells genetically modified to secrete nerve growth factor. Neurobiol Dis. 1994 Nov; 1(1-2):67-78. Tuszynski MH, Senut MC, Ray J, Roberts J. PMID: 9216988.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    212. Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp Neurol. 1994 Mar; 126(1):1-14. Tuszynski MH, Peterson DA, Ray J, Baird A, Nakahara Y, Gage FH. PMID: 8157119.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    213. Neurotrophic factors and diseases of the nervous system. Ann Neurol. 1994; 35 Suppl:S9-12. Tuszynski MH, Gage FH. PMID: 8185304.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    214. Ataxia in epidural spinal cord compression. Neurology. 1992 Nov; 42(11):2193-5. Hainline B, Tuszynski MH, Posner JB. PMID: 1436534.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    215. Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann Neurol. 1991 Nov; 30(5):625-36. Tuszynski MH, Sang H, Yoshida K, Gage FH. PMID: 1763889.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    216. In vivo assay of neuron-specific effects of nerve growth factor. Methods Enzymol. 1991; 198:35-48. Tuszynski MH, Gage FH. PMID: 1857228.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    217. Nerve growth factor function in the central nervous system. Curr Top Microbiol Immunol. 1991; 165:71-93. Gage FH, Tuszynski MH, Chen KS, Fagan AM, Higgins GA. PMID: 2032465.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    218. Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci. 1990 Nov; 10(11):3604-14. Tuszynski MH, U HS, Amaral DG, Gage FH. PMID: 2230949; PMCID: PMC6570113.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    219. Human beta nerve growth factor obtained from a baculovirus expression system has potent in vitro and in vivo neurotrophic activity. Exp Neurol. 1990 Oct; 110(1):11-24. Barnett J, Baecker P, Routledge-Ward C, Bursztyn-Pettegrew H, Chow J, Nguyen B, Bach C, Chan H, Tuszynski MH, Yoshida K, et al. PMID: 2209779.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    220. Basal forebrain cell loss following fimbria/fornix transection. Brain Res. 1990 Feb 05; 508(2):241-8. Tuszynski MH, Armstrong DM, Gage FH. PMID: 2306615.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    221. Grafting genetically modified cells to the brain: conceptual and technical issues. Prog Brain Res. 1990; 82:1-10. Gage FH, Fisher LJ, Jinnah HA, Rosenberg MB, Tuszynski MH, Friedmann T. PMID: 1981271.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    222. Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Prog Brain Res. 1990; 86:205-17. Gage FH, Rosenberg MB, Tuszynski MH, Yoshida K, Armstrong DM, Hayes RC, Friedmann T. PMID: 2087558.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    223. Nerve growth factor infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection. Neuroscience. 1990; 36(1):33-44. Tuszynski MH, Buzsaki G, Gage FH. PMID: 1699159.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    224. Potential use of neurotrophic agents in the treatment of neurodegenerative disorders. Acta Neurobiol Exp (Wars). 1990; 50(4-5):311-22. Tuszynski MH, Gage FH. PMID: 2130651.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    225. Role of neurotrophic factors in Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):545-6; discussion 552-3. Chen KS, Tuszynski MH, Gage FH. PMID: 2812224.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    226. Delivery of neuroactive compounds to the brain: potential utility of genetically modified cells. Neurobiol Aging. 1989 Sep-Oct; 10(5):644-5; discussion 648-50. Tuszynski MH, Jinnah HA, Gage FH. PMID: 2812247.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    227. Survival, growth and function of damaged cholinergic neurons. EXS. 1989; 57:259-74. Gage FH, Tuszynski MH, Chen KS, Armstrong D, Buzsáki G. PMID: 2533097.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    228. Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science. 1988 Dec 16; 242(4885):1575-8. Rosenberg MB, Friedmann T, Robertson RC, Tuszynski M, Wolff JA, Breakefield XO, Gage FH. PMID: 3201248.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    229. Ischemic thalamic aphasia with pathologic confirmation. Neurology. 1988 May; 38(5):800-2. Tuszynski MH, Petito CK. PMID: 3362379.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
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