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Focal adhesion kinase signaling - tumor vulnerabilities and clinical opportunities. J Cell Sci. 2024 07 15; 137(14).
Schlaepfer DD, Ojalill M, Stupack DG. PMID: 39034922; PMCID: PMC11298715.
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PubMed Mentions: Fields:
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HumansAnimalsCells
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Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer. Cancers (Basel). 2023 Jun 21; 15(13).
Contadini C, Ferri A, Cirotti C, Stupack D, Barilà D. PMID: 37444381; PMCID: PMC10340071.
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PubMed Mentions:
3
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Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy. Cell Death Differ. 2023 02; 30(2):417-428.
Contadini C, Ferri A, Di Martile M, Cirotti C, Del Bufalo D, De Nicola F, Pallocca M, Fanciulli M, Sacco F, Donninelli G, Capone A, Volpe E, Keller N, Miki S, Kawauchi D, Stupack D, Furnari F, Barilà D. PMID: 36460775; PMCID: PMC9950463.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Nonsense-mediated RNA decay: an emerging modulator of malignancy. Nat Rev Cancer. 2022 08; 22(8):437-451.
Tan K, Stupack DG, Wilkinson MF. PMID: 35624152; PMCID: PMC11009036.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis. Proc Natl Acad Sci U S A. 2022 04 26; 119(17):e2117065119.
Ozmadenci D, Shankara Narayanan JS, Andrew J, Ojalill M, Barrie AM, Jiang S, Iyer S, Chen XL, Rose M, Estrada V, Molinolo A, Bertotto T, Mikulski Z, McHale MC, White RR, Connolly DC, Pachter JA, Kuchroo VK, Stupack DG, Schlaepfer DD. PMID: 35467979; PMCID: PMC9169934.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
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Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse. J Transl Med. 2021 10 15; 19(1):428.
Secchi C, Belli M, Harrison TNH, Swift J, Ko C, Duleba AJ, Stupack D, Chang RJ, Shimasaki S. PMID: 34654452; PMCID: PMC8520195.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Association of Copy Number Variation Signature and Survival in Patients With Serous Ovarian Cancer. JAMA Netw Open. 2021 06 01; 4(6):e2114162.
Graf RP, Eskander R, Brueggeman L, Stupack DG. PMID: 34181012; PMCID: PMC8239953.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Targeting FAK in anticancer combination therapies. Nat Rev Cancer. 2021 05; 21(5):313-324.
Dawson JC, Serrels A, Stupack DG, Schlaepfer DD, Frame MC. PMID: 33731845; PMCID: PMC8276817.
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PubMed Mentions:
104 Fields:
Translation:
HumansAnimals
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FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor. J Transl Med. 2021 02 27; 19(1):90.
Secchi C, Benaglio P, Mulas F, Belli M, Stupack D, Shimasaki S. PMID: 33639972; PMCID: PMC7913442.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, et al. PMID: 33634751; PMCID: PMC7996087.
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PubMed Mentions:
1041 Fields:
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HumansAnimalsCells
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Retraction for Nasimuzzaman et al., "Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor". J Virol. 2020 09 15; 94(19).
Nasimuzzaman M, Waris G, Mikolon D, Stupack DG, Siddiqui A. PMID: 32934071; PMCID: PMC7495360.
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PubMed Mentions: Fields:
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Underlying Subwavelength Aperture Architecture Drives the Optical Properties of Microcavity Surface Plasmon Resonance Sensors. Sensors (Basel). 2020 Aug 30; 20(17).
Amarie D, Mosavian N, Waters EL, Stupack DG. PMID: 32872658; PMCID: PMC7506739.
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PubMed Mentions: Fields:
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Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. PLoS Genet. 2020 01; 16(1):e1008558.
Delaney JR, Patel CB, Bapat J, Jones CM, Ramos-Zapatero M, Ortell KK, Tanios R, Haghighiabyaneh M, Axelrod J, DeStefano JW, Tancioni I, Schlaepfer DD, Harismendy O, La Spada AR, Stupack DG. PMID: 31923184; PMCID: PMC6953790.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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RHAMM inhibits cell migration via the AKT/GSK3β/Snail axis in luminal A subtype breast cancer. Anat Rec (Hoboken). 2020 09; 303(9):2344-2356.
Wang J, Li D, Shen W, Sun W, Gao R, Jiang P, Wang L, Liu Y, Chen Y, Zhou W, Wang R, Xiang R, Stupack D, Luo N. PMID: 31769593.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Elife. 2019 09 03; 8.
Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. PMID: 31478830; PMCID: PMC6721800.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3. J Endocr Soc. 2019 Nov 01; 3(11):2064-2081.
Belli M, Secchi C, Stupack D, Shimasaki S. PMID: 31701078; PMCID: PMC6797057.
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PubMed Mentions:
5
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Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. Oncogene. 2019 09; 38(36):6323-6337.
Kleinschmidt EG, Miller NLG, Ozmadenci D, Tancioni I, Osterman CD, Barrie AM, Taylor KN, Ye A, Jiang S, Connolly DC, Stupack DG, Schlaepfer DD. PMID: 31308489; PMCID: PMC7252434.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism. Theranostics. 2018; 8(22):6248-6262.
Gao R, Li D, Xun J, Zhou W, Li J, Wang J, Liu C, Li X, Shen W, Qiao H, Stupack DG, Luo N. PMID: 30613295; PMCID: PMC6299690.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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PFKFB4 Promotes Breast Cancer Metastasis via Induction of Hyaluronan Production in a p38-Dependent Manner. Cell Physiol Biochem. 2018; 50(6):2108-2123.
Gao R, Liu Y, Li D, Xun J, Zhou W, Wang P, Liu C, Li X, Shen W, Su W, Qiao H, Stupack DG, Luo N. PMID: 30415245.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells. Endocrinology. 2018 04 01; 159(4):1690-1703.
Belli M, Iwata N, Nakamura T, Iwase A, Stupack D, Shimasaki S. PMID: 29471425; PMCID: PMC6238151.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Caspase-8 function, and phosphorylation, in cell migration. Semin Cell Dev Biol. 2018 10; 82:105-117.
Keller N, Ozmadenci D, Ichim G, Stupack D. PMID: 29410361.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Duodenal-Jejunal Flexure GI Stromal Tumor Frequently Heralds Somatic NF1 and Notch Pathway Mutations. JCO Precis Oncol. 2017; 2017.
Burgoyne AM, De Siena M, Alkhuziem M, Tang CM, Medina B, Fanta PT, Belinsky MG, von Mehren M, Thorson JA, Madlensky L, Bowler T, D'Angelo F, Stupack DG, Harismendy O, DeMatteo RP, Sicklick JK. PMID: 29938249; PMCID: PMC6013064.
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PubMed Mentions:
13 Fields:
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Alternative promotion and suppression of metastasis by JNK2 governed by its phosphorylation. Oncotarget. 2017 Aug 22; 8(34):56569-56581.
Hu S, Dong X, Gao W, Stupack D, Liu Y, Xiang R, Li N. PMID: 28915613; PMCID: PMC5593584.
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PubMed Mentions:
3 Fields:
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Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer. Nat Commun. 2017 02 15; 8:14423.
Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG. PMID: 28198375; PMCID: PMC5316854.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas. PLoS One. 2016; 11(7):e0159114.
Delaney JR, Stupack DG. PMID: 27391266; PMCID: PMC4938382.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings. Drug Des Devel Ther. 2016; 10:1837-46.
Davis MA, Delaney JR, Patel CB, Storgard R, Stupack DG. PMID: 27330277; PMCID: PMC4898046.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. Oncotarget. 2016 May 17; 7(20):29387-99.
Zhang Y, Shen L, Stupack DG, Bai N, Xun J, Ren G, Han J, Li L, Luo Y, Xiang R, Tan X. PMID: 27102442; PMCID: PMC5045403.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. 2015 Oct 26; 4:e173.
Shen W, Chang A, Wang J, Zhou W, Gao R, Li J, Xu Y, Luo X, Xiang R, Luo N, Stupack DG. PMID: 26501855; PMCID: PMC4632091.
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PubMed Mentions:
18
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A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. Oncotarget. 2015 Oct 13; 6(31):31104-18.
Delaney JR, Patel C, McCabe KE, Lu D, Davis MA, Tancioni I, von Schalscha T, Bartakova A, Haft C, Schlaepfer DD, Stupack DG. PMID: 26418751; PMCID: PMC4741591.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Role of Hyaluronan and Glucose on 4-Methylumbelliferone-inhibited Cell Proliferation in Breast Carcinoma Cells. Anticancer Res. 2015 Sep; 35(9):4799-805.
Wang R, Zhou W, Wang J, Liu Y, Chen Y, Jiang S, Luo X, Stupack DG, Luo N. PMID: 26254370.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. PLoS One. 2015; 10(5):e0120815.
Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG. PMID: 25973900; PMCID: PMC4431816.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma. Cell Death Dis. 2014 Oct 30; 5:e1496.
McCabe KE, Bacos K, Lu D, Delaney JR, Axelrod J, Potter MD, Vamos M, Wong V, Cosford ND, Xiang R, Stupack DG. PMID: 25356865; PMCID: PMC4237265.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem. 2014 Jun 20; 289(25):17689-98.
Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown JH. PMID: 24790104; PMCID: PMC4067203.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion. J Cell Sci. 2014 Jun 01; 127(Pt 11):2401-6.
Díaz J, Mendoza P, Ortiz R, Díaz N, Leyton L, Stupack D, Quest AF, Torres VA. PMID: 24659799; PMCID: PMC4074264.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Caspase-8 as a regulator of tumor cell motility. Curr Mol Med. 2014 Feb; 14(2):246-54.
Graf RP, Keller N, Barbero S, Stupack D. PMID: 24467204; PMCID: PMC4106798.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
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Tumor angiogenesis: putting a value on plastic GEMMs. Circ Res. 2014 Jan 03; 114(1):9-11.
Cheresh DA, Stupack DG. PMID: 24385501; PMCID: PMC4090242.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells. Carcinogenesis. 2014 Mar; 35(3):613-23.
Chen S, Li X, Lu D, Xu Y, Mou W, Wang L, Chen Y, Liu Y, Li X, Li LY, Liu L, Stupack D, Reisfeld RA, Xiang R, Li N. PMID: 24233838.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells. J Cell Sci. 2013 Sep 01; 126(Pt 17):3835-47.
Mendoza P, Ortiz R, Díaz J, Quest AF, Leyton L, Stupack D, Torres VA. PMID: 23813952; PMCID: PMC4074302.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adh Migr. 2013 Jul-Aug; 7(4):362-9.
Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D. PMID: 23751956; PMCID: PMC3739813.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53. Cancer Biol Ther. 2013 Jun; 14(6):511-20.
Bai N, Zhang C, Liang N, Zhang Z, Chang A, Yin J, Li Z, Luo N, Tan X, Luo N, Luo Y, Xiang R, Li X, Reisfeld RA, Stupack D, Lv D, Liu C. PMID: 23760493; PMCID: PMC3813567.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis. 2013 Jun; 30(5):579-94.
Ward KK, Tancioni I, Lawson C, Miller NL, Jean C, Chen XL, Uryu S, Kim J, Tarin D, Stupack DG, Plaxe SC, Schlaepfer DD. PMID: 23275034; PMCID: PMC3622195.
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PubMed Mentions:
67 Fields:
Translation:
Humans
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Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer. J Cell Biochem. 2012 Aug; 113(8):2679-86.
Wang L, Chen S, Zhang M, Li N, Chen Y, Su W, Liu Y, Lu D, Li S, Yang Y, Li Z, Stupack D, Qu P, Hu H, Xiang R. PMID: 22441772.
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PubMed Mentions:
45 Fields:
Translation:
Humans
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Fra-1 promotes breast cancer chemosensitivity by driving cancer stem cells from dormancy. Cancer Res. 2012 Jul 15; 72(14):3451-6.
Lu D, Chen S, Tan X, Li N, Liu C, Li Z, Liu Z, Stupack DG, Reisfeld RA, Xiang R. PMID: 22586064.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. PLoS One. 2012; 7(5):e36753.
Lau SK, Shields DJ, Murphy EA, Desgrosellier JS, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA. PMID: 22586492; PMCID: PMC3346745.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules. Apoptosis. 2012 Mar; 17(3):229-35.
Yuan RT, Young S, Liang J, Schmid MC, Mielgo A, Stupack DG. PMID: 22160860.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles. Angew Chem Int Ed Engl. 2011 Dec 16; 50(51):12308-11.
Kinsella JM, Jimenez RE, Karmali PP, Rush AM, Kotamraju VR, Gianneschi NC, Ruoslahti E, Stupack D, Sailor MJ. PMID: 22028313; PMCID: PMC3530424.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts. Int J Oncol. 2011 Aug; 39(2):393-400.
DE Wever O, Sobczak-Thépot J, Vercoutter-Edouart AS, Michalski JC, Ouelaa-Benslama R, Stupack DG, Bracke M, Wang JYJ, Gespach C, Emami S. PMID: 21567080; PMCID: PMC5003111.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Rab5 in the regulation of cell motility and invasion. Curr Protein Pept Sci. 2011 Feb; 12(1):43-51.
Torres VA, Stupack DG. PMID: 21190523.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Caspase-8 as a therapeutic target in cancer. Cancer Lett. 2013 May 28; 332(2):133-40.
Stupack DG. PMID: 20817393; PMCID: PMC3049203.
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PubMed Mentions:
72 Fields:
Translation:
HumansCells
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PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15; 9(10):764-77.
Tanjoni I, Walsh C, Uryu S, Tomar A, Nam JO, Mielgo A, Lim ST, Liang C, Koenig M, Sun C, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD. PMID: 20234191; PMCID: PMC2933317.
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PubMed Mentions:
98 Fields:
Translation:
AnimalsCells
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Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther. 2010 May 15; 9(10):778-90.
Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD. PMID: 20234193; PMCID: PMC2933309.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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Selection in spatial stochastic models of cancer: migration as a key modulator of fitness. Biol Direct. 2010 Apr 20; 5:21.
Thalhauser CJ, Lowengrub JS, Stupack D, Komarova NL. PMID: 20406439; PMCID: PMC2873940.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Applications of a new In vivo tumor spheroid based shell-less chorioallantoic membrane 3-D model in bioengineering research. J Biomed Sci Eng. 2010 Jan 01; 3(1):20-26.
De Magalhães N, Liaw LH, Berns M, Cristini V, Chen Z, Stupack D, Lowengrub J. PMID: 21243108; PMCID: PMC3019609.
View in:
PubMed Mentions:
1
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Rab5 mediates caspase-8-promoted cell motility and metastasis. Mol Biol Cell. 2010 Jan 15; 21(2):369-76.
Torres VA, Mielgo A, Barbero S, Hsiao R, Wilkins JA, Stupack DG. PMID: 19923319; PMCID: PMC2808229.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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The death effector domains of caspase-8 induce terminal differentiation. PLoS One. 2009 Nov 18; 4(11):e7879.
Mielgo A, Torres VA, Schmid MC, Graf R, Zeitlin SG, Lee P, Shields DJ, Barbero S, Jamora C, Stupack DG. PMID: 19924290; PMCID: PMC2774162.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 08; 28(40):3551-62.
Mielgo A, Torres VA, Clair K, Barbero S, Stupack DG. PMID: 19668227; PMCID: PMC2851247.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Agonizing integrin antagonists? Cancer Cell. 2009 May 05; 15(5):359-61.
Weis SM, Stupack DG, Cheresh DA. PMID: 19411065.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res. 2009 May 01; 69(9):3755-63.
Barbero S, Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barilà D, Lahti JM, Schlaepfer D, Stupack DG. PMID: 19383910; PMCID: PMC2684981.
View in:
PubMed Mentions:
77 Fields:
Translation:
HumansAnimalsCells
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Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med. 2009 Apr 13; 206(4):833-47.
Delloye-Bourgeois C, Fitamant J, Paradisi A, Cappellen D, Douc-Rasy S, Raquin MA, Stupack D, Nakagawara A, Rousseau R, Combaret V, Puisieux A, Valteau-Couanet D, Bénard J, Bernet A, Mehlen P. PMID: 19349462; PMCID: PMC2715117.
View in:
PubMed Mentions:
74 Fields:
Translation:
HumansCells
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Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. J Cell Biol. 2008 Nov 17; 183(4):711-23.
Huang X, Wu D, Jin H, Stupack D, Wang JY. PMID: 19001122; PMCID: PMC2582888.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Caspase 8 promotes peripheral localization and activation of Rab5. J Biol Chem. 2008 Dec 26; 283(52):36280-9.
Torres VA, Mielgo A, Barilà D, Anderson DH, Stupack D. PMID: 18974049; PMCID: PMC2605999.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Regulation of angiogenesis: apoptotic cues from the ECM. Oncogene. 2008 Oct 20; 27(48):6285-98.
Cheresh DA, Stupack DG. PMID: 18931694.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61. FASEB J. 2008 Nov; 22(11):4011-21.
Walsh CT, Radeff-Huang J, Matteo R, Hsiao A, Subramaniam S, Stupack D, Brown JH. PMID: 18687805; PMCID: PMC3980657.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
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G protein-coupled receptors go extracellular: RhoA integrates the integrins. Mol Interv. 2008 Aug; 8(4):165-73.
Walsh CT, Stupack D, Brown JH. PMID: 18829842; PMCID: PMC2637220.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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FERM control of FAK function: implications for cancer therapy. Cell Cycle. 2008 Aug; 7(15):2306-14.
Lim ST, Mikolon D, Stupack DG, Schlaepfer DD. PMID: 18677107; PMCID: PMC2574722.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells
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The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8.
Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG. PMID: 18268346; PMCID: PMC2268133.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J Biol Chem. 2008 May 09; 283(19):13031-4.
Barbero S, Barilà D, Mielgo A, Stagni V, Clair K, Stupack D. PMID: 18216014; PMCID: PMC2442311.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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The CD44 standard/ezrin complex regulates Fas-mediated apoptosis in Jurkat cells. Apoptosis. 2007 Nov; 12(11):2051-61.
Mielgo A, Brondani V, Landmann L, Glaser-Ruhm A, Erb P, Stupack D, Günthert U. PMID: 17726647.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility. Oncogene. 2008 Feb 28; 27(10):1439-48.
Wu L, Bernard-Trifilo JA, Lim Y, Lim ST, Mitra SK, Uryu S, Chen M, Pallen CJ, Cheung NK, Mikolon D, Mielgo A, Stupack DG, Schlaepfer DD. PMID: 17828307; PMCID: PMC2593630.
View in:
PubMed Mentions:
63 Fields:
Translation:
HumansCells
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The biology of integrins. Oncology (Williston Park). 2007 Aug; 21(9 Suppl 3):6-12.
Stupack DG. PMID: 17927025.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J Virol. 2007 Oct; 81(19):10249-57.
Nasimuzzaman M, Waris G, Mikolon D, Stupack DG, Siddiqui A. PMID: 17626077; PMCID: PMC2045478.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Cell survival in a three-dimensional matrix. Methods Enzymol. 2007; 426:85-101.
Alavi A, Stupack DG. PMID: 17697881.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Does integrin-mediated cell death confer tissue tropism in metastasis? Cancer Res. 2006 Jun 15; 66(12):5981-4.
Lahti JM, Teitz T, Stupack DG. PMID: 16778165.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene. 2006 Sep 28; 25(44):5969-84.
Mitra SK, Mikolon D, Molina JE, Hsia DA, Hanson DA, Chi A, Lim ST, Bernard-Trifilo JA, Ilic D, Stupack DG, Cheresh DA, Schlaepfer DD. PMID: 16682956.
View in:
PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Halting neuroblastoma metastasis by controlling integrin-mediated death. Cell Cycle. 2006 Apr; 5(7):681-5.
Teitz T, Stupack DG, Lahti JM. PMID: 16582638.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature. J Clin Invest. 2006 Mar; 116(3):652-62.
Jin H, Aiyer A, Su J, Borgstrom P, Stupack D, Friedlander M, Varner J. PMID: 16498499; PMCID: PMC1378185.
View in:
PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature. 2006 Jan 05; 439(7072):95-9.
Stupack DG, Teitz T, Potter MD, Mikolon D, Houghton PJ, Kidd VJ, Lahti JM, Cheresh DA. PMID: 16397500.
View in:
PubMed Mentions:
108 Fields:
Translation:
HumansAnimalsCells
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Integrins as a distinct subtype of dependence receptors. Cell Death Differ. 2005 Aug; 12(8):1021-30.
Stupack DG. PMID: 15933741.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Angiogenesis assays in the chick CAM. Methods Mol Biol. 2005; 294:123-36.
Storgard C, Mikolon D, Stupack DG. PMID: 15576910.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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A Bit-role for integrins in apoptosis. Nat Cell Biol. 2004 May; 6(5):388-9.
Stupack DG, Cheresh DA. PMID: 15122265.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Integrins and angiogenesis. Curr Top Dev Biol. 2004; 64:207-38.
Stupack DG, Cheresh DA. PMID: 15563949.
View in:
PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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Apoptotic cues from the extracellular matrix: regulators of angiogenesis. Oncogene. 2003 Dec 08; 22(56):9022-9.
Stupack DG, Cheresh DA. PMID: 14663480.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Role of Raf in vascular protection from distinct apoptotic stimuli. Science. 2003 Jul 04; 301(5629):94-6.
Alavi A, Hood JD, Frausto R, Stupack DG, Cheresh DA. PMID: 12843393.
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PubMed Mentions:
104 Fields:
Translation:
HumansAnimalsCells
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Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003 Jul; 112(1):30-41.
Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. PMID: 12840057; PMCID: PMC162283.
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PubMed Mentions:
34 Fields:
Translation:
Animals
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Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells. J Lipid Res. 2003 Aug; 44(8):1453-61.
Desrumaux CM, Mak PA, Boisvert WA, Masson D, Stupack D, Jauhiainen M, Ehnholm C, Curtiss LK. PMID: 12730304.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci. 2002 Oct 01; 115(Pt 19):3729-38.
Stupack DG, Cheresh DA. PMID: 12235283.
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PubMed Mentions:
187 Fields:
Translation:
HumansAnimalsCells
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Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002 Apr 01; 157(1):149-60.
Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA. PMID: 11927607; PMCID: PMC2173263.
View in:
PubMed Mentions:
138 Fields:
Translation:
HumansAnimalsCells
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Integrin-mediated death: an explanation of the integrin-knockout phenotype? Nat Med. 2002 Mar; 8(3):193-4.
Cheresh DA, Stupack DG. PMID: 11875466.
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PubMed Mentions:
31 Fields:
Translation:
Animals
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ECM remodeling regulates angiogenesis: endothelial integrins look for new ligands. Sci STKE. 2002 Feb 12; 2002(119):pe7.
Stupack DG, Cheresh DA. PMID: 11842241.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol. 2001 Oct 29; 155(3):459-70.
Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM, Cheresh DA. PMID: 11684710; PMCID: PMC2150834.
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PubMed Mentions:
157 Fields:
Translation:
AnimalsCells
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Integrin alpha(v)beta1 is an adenovirus coreceptor. J Virol. 2001 Jun; 75(11):5405-9.
Li E, Brown SL, Stupack DG, Puente XS, Cheresh DA, Nemerow GR. PMID: 11333925; PMCID: PMC114949.
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PubMed Mentions:
78 Fields:
Translation:
HumansCells
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Perturbation of rat renal tubule transport of the organic cation amantadine in recent onset streptozotocin-induced diabetes and in uninephrectomy. Can J Physiol Pharmacol. 2001 Jan; 79(1):18-24.
Goralski KB, Stupack DG, Hatch GM, Sitar DS. PMID: 11201497.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J Biol Chem. 2000 May 12; 275(19):14729-35.
Li E, Stupack DG, Brown SL, Klemke R, Schlaepfer DD, Nemerow GR. PMID: 10799562.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Cell growth and matrix invasion of EBV-immortalized human B lymphocytes is regulated by expression of alpha(v) integrins. Oncogene. 2000 Apr 06; 19(15):1915-23.
Huang S, Stupack D, Liu A, Cheresh D, Nemerow GR. PMID: 10773881.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Molecular signaling mechanisms of cell migration and invasion. Immunol Res. 2000; 21(2-3):83-8.
Stupack DG, Cho SY, Klemke RL. PMID: 10852105.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand. J Biol Chem. 1999 Jul 30; 274(31):21609-16.
Pampori N, Hato T, Stupack DG, Aidoudi S, Cheresh DA, Nemerow GR, Shattil SJ. PMID: 10419468.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Heterogeneity among beta-adrenoreceptor blockers in the modulation of energy-dependent uptake of the organic cation amantadine by rat renal tubules. Can J Physiol Pharmacol. 1999 Jun; 77(6):407-13.
Stupack DG, Escobar MR, Carlisle M, Davie T, Sitar DS. PMID: 10537226.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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A role for angiogenesis in rheumatoid arthritis. Braz J Med Biol Res. 1999 May; 32(5):573-81.
Stupack DG, Storgard CM, Cheresh DA. PMID: 10412569.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol. 1999 Feb 22; 144(4):777-88.
Stupack DG, Li E, Silletti SA, Kehler JA, Geahlen RL, Hahn K, Nemerow GR, Cheresh DA. PMID: 10037798; PMCID: PMC2132930.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. J Clin Invest. 1999 Jan; 103(1):47-54.
Storgard CM, Stupack DG, Jonczyk A, Goodman SL, Fox RI, Cheresh DA. PMID: 9884333; PMCID: PMC407856.
View in:
PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases. J Virol. 1998 Nov; 72(11):8806-12.
Li E, Stupack D, Bokoch GM, Nemerow GR. PMID: 9765425; PMCID: PMC110297.
View in:
PubMed Mentions:
105 Fields:
Translation:
HumansCells
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Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase. J Virol. 1998 Mar; 72(3):2055-61.
Li E, Stupack D, Klemke R, Cheresh DA, Nemerow GR. PMID: 9499060; PMCID: PMC109499.
View in:
PubMed Mentions:
104 Fields:
Translation:
HumansCells
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Growth arrest of Epstein-Barr virus immortalized B lymphocytes by adenovirus-delivered ribozymes. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8156-61.
Huang S, Stupack D, Mathias P, Wang Y, Nemerow G. PMID: 9223331; PMCID: PMC21573.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Control of beta1 integrin function. Localization of stimulatory epitopes. J Biol Chem. 1996 Feb 09; 271(6):3046-51.
Wilkins JA, Li A, Ni H, Stupack DG, Shen C. PMID: 8621699.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Control of lymphocyte integrin function: evidence for multiple contributing factors. Cell Immunol. 1994 Apr 15; 155(1):237-45.
Stupack DG, Shen C, Wilkins JA. PMID: 7513261.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Induction of alpha v beta 3 integrin-mediated attachment to extracellular matrix in beta 1 integrin (CD29)-negative B cell lines. Exp Cell Res. 1992 Dec; 203(2):443-8.
Stupack DG, Shen C, Wilkins JA. PMID: 1281112.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
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The interactions of gamma delta T cells with extracellular matrix: receptor expression and utilization patterns. Scand J Immunol. 1992 Aug; 36(2):213-9.
Wilkins J, Selin L, Stewart S, Sivananthan K, Stupack D. PMID: 1380178.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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B lymphocyte fibronectin receptors: expression and utilization. Scand J Immunol. 1991 Dec; 34(6):761-9.
Stupack DG, Stewart S, Carter WG, Wayner EA, Wilkins JA. PMID: 1836275.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Beta 1 integrin-mediated lymphocyte adherence to extracellular matrix is enhanced by phorbol ester treatment. Eur J Immunol. 1991 Feb; 21(2):517-22.
Wilkins JA, Stupack D, Stewart S, Caixia S. PMID: 1999229.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells