Aleem Siddiqui

Title(s)	Recall Hcomp, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Epitranscriptomic regulation of HBV gene expression
NIH R01AI139234Mar 1, 2019 - Feb 29, 2024
Role: Principal Investigator

Epitranscriptomic regulation of HBV gene expression
NIH R56AI139234Jul 16, 2018 - Feb 28, 2019
Role: Principal Investigator

Mechanisms of HBV-Induced Innate Immunity
NIH R01AI125350Jun 23, 2017 - May 31, 2022
Role: Principal Investigator

2016 Internatinal Meeting o the Molecular Biology of Hepatitis B Viruses
NIH R13AI124562Jul 19, 2016 - Jun 30, 2017
Role: Principal Investigator

Intervention of HBV DNA synthesis and transcription
NIH R21AI105939Sep 6, 2013 - Aug 31, 2015
Role: Principal Investigator

Hepatitis C Virus-Induced Liver Pathogenesis
NIH R01DK083479Sep 30, 2010 - Aug 31, 2014
Role: Principal Investigator

Role of Lipids in Hepatitis C Virus Maturation
NIH R01AI085087Jul 1, 2010 - Mar 31, 2020
Role: Principal Investigator

Role of Lipids in Hepatitis C Virus Maturation
NIH R56AI085087Dec 1, 2009 - Mar 31, 2015
Role: Principal Investigator

Viral Hepatitis C and Lipid Homeostasis
NIH R01DK077704Apr 1, 2007 - Dec 31, 2017
Role: Principal Investigator

Determinants of Liver Injury in Chronic Hepatitis C Virus Infection
NIH U19AI066313Sep 1, 2005 - Nov 28, 2010
Role: Co-Investigator

Hepatitis C Virus NS5a Protein and Oxidative Stress
NIH R01DK061566Jan 8, 2003 - Dec 31, 2008
Role: Principal Investigator

LIVER-SPECIFIC EXPRESSION OF HBV GENES
NIH R01CA078769Jan 19, 2000 - Dec 31, 2004
Role: Principal Investigator

Comprehensive Biology: Exploiting the Yeast Genome
NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
Role: Co-Investigator

HBV induced Liver Pathogenesis
NIH R01CA064415Apr 1, 1996 - Sep 30, 2007
Role: Principal Investigator

INDO-US VACCINE ACTION PROGRAM
NIH R03AI031994Sep 15, 1991 - Aug 31, 1994
Role: Principal Investigator

HEPATITIS B VIRUS DNA AS COCARCINOGEN IN KAPOSI SARCOMA
NIH U01AI021182Apr 1, 1984 - Mar 31, 1987
Role: Principal Investigator

EXPRESSION OF HBV GENES AND HEPATOMA
NIH R01CA033135Jul 1, 1982 - Nov 30, 1995
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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N6-Methyladenine Modification of Hepatitis Delta Virus Regulates Its Virion Assembly by Recruiting YTHDF1. J Virol. 2022 10 12; 96(19):e0112422. Kim GW, Moon JS, Gudima SO, Siddiqui A. PMID: 36102650; PMCID: PMC9555152.

View in: PubMed Mentions: 1 Fields:
Vir Virology
Translation:Humans Cells
N6-methyladenosine modification of the 5' epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein. Proc Natl Acad Sci U S A. 2022 02 15; 119(7). Kim GW, Moon JS, Siddiqui A. PMID: 35135882; PMCID: PMC8851549.

View in: PubMed Mentions: 8 Fields:
Sci Science
Translation:Cells
Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA. J Virol. 2022 02 23; 96(4):e0165521. Kim GW, Siddiqui A. PMID: 34851655; PMCID: PMC8865537.

View in: PubMed Mentions: 13 Fields:
Vir Virology
Translation:Humans Cells
The RNA Binding Proteins YTHDC1 and FMRP Regulate the Nuclear Export of N6-Methyladenosine-Modified Hepatitis B Virus Transcripts and Affect the Viral Life Cycle. J Virol. 2021 06 10; 95(13):e0009721. Kim GW, Imam H, Siddiqui A. PMID: 33883220; PMCID: PMC8316146.

View in: PubMed Mentions: 26 Fields:
Vir Virology
Translation:Humans Cells
The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses. Exp Mol Med. 2021 03; 53(3):339-345. Kim GW, Siddiqui A. PMID: 33742132; PMCID: PMC8080661.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Humans Animals Cells
N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). Kim GW, Siddiqui A. PMID: 33649237; PMCID: PMC7958429.

View in: PubMed Mentions: 23 Fields:
Sci Science
Translation:Humans Cells
Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). Kim GW, Siddiqui A. PMID: 33397803; PMCID: PMC7826408.

View in: PubMed Mentions: 36 Fields:
Sci Science
Translation:Humans Cells
Epitranscriptomic(N6-methyladenosine) Modification of Viral RNA and Virus-Host Interactions. Front Cell Infect Microbiol. 2020; 10:584283. Imam H, Kim GW, Siddiqui A. PMID: 33330128; PMCID: PMC7732492.

View in: PubMed Mentions: 28 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Cells
HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC. Hepatology. 2021 02; 73(2):533-547. Kim GW, Imam H, Khan M, Mir SA, Kim SJ, Yoon SK, Hur W, Siddiqui A. PMID: 32394474; PMCID: PMC7655655.

View in: PubMed Mentions: 54 Fields:
Gas Gastroenterology
Translation:Humans Cells
Retraction for Nasimuzzaman et al., "Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor". J Virol. 2020 09 15; 94(19). Nasimuzzaman M, Waris G, Mikolon D, Stupack DG, Siddiqui A. PMID: 32934071; PMCID: PMC7495360.

View in: PubMed Mentions: Fields:
Vir Virology
Retraction for Waris et al., "Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress". J Virol. 2020 09 15; 94(19). Waris G, Felmlee DJ, Negro F, Siddiqui A. PMID: 32934072; PMCID: PMC7495369.

View in: PubMed Mentions: Fields:
Vir Virology
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling. J Biol Chem. 2020 09 11; 295(37):13123-13133. Kim GW, Imam H, Khan M, Siddiqui A. PMID: 32719095; PMCID: PMC7489896.

View in: PubMed Mentions: 61 Fields:
Bio Biochemistry
Translation:Humans Cells
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts. PLoS Pathog. 2020 02; 16(2):e1008338. Imam H, Kim GW, Mir SA, Khan M, Siddiqui A. PMID: 32059034; PMCID: PMC7046284.

View in: PubMed Mentions: 68 Fields:
Mic Microbiology
Translation:Humans Cells
Subversion of cellular autophagy during virus infection: Insights from hepatitis B and hepatitis C viruses. Liver Res. 2018 Sep; 2(3):146-156. Khan M, Imam H, Siddiqui A. PMID: 31803515; PMCID: PMC6892584.

View in: PubMed Mentions: 11
N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):8829-8834. Imam H, Khan M, Gokhale NS, McIntyre ABR, Kim GW, Jang JY, Kim SJ, Mason CE, Horner SM, Siddiqui A. PMID: 30104368; PMCID: PMC6126736.

View in: PubMed Mentions: 109 Fields:
Sci Science
Translation:Humans Cells
Hepatitis C Virus Lipoviroparticles Assemble in the Endoplasmic Reticulum (ER) and Bud off from the ER to the Golgi Compartment in COPII Vesicles. J Virol. 2017 08 01; 91(15). Syed GH, Khan M, Yang S, Siddiqui A. PMID: 28515296; PMCID: PMC5512234.

View in: PubMed Mentions: 22 Fields:
Vir Virology
Translation:Humans Cells
Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity. PLoS Pathog. 2016 06; 12(6):e1005693. Khan M, Syed GH, Kim SJ, Siddiqui A. PMID: 27348524; PMCID: PMC4922663.

View in: PubMed Mentions: 57 Fields:
Mic Microbiology
Translation:Humans Cells
Mitochondrial dynamics and viral infections: A close nexus. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt B):2822-33. Khan M, Syed GH, Kim SJ, Siddiqui A. PMID: 25595529; PMCID: PMC4500740.

View in: PubMed Mentions: 95 Fields:
Bio Biochemistry Bio Biophysics
Translation:Humans Animals Cells
Evolutionary trends and functional anatomy of the human expanded autophagy network. Autophagy. 2015; 11(9):1652-67. Till A, Saito R, Merkurjev D, Liu JJ, Syed GH, Kolnik M, Siddiqui A, Glas M, Scheffler B, Ideker T, Subramani S. PMID: 26103419; PMCID: PMC4590607.

View in: PubMed Mentions: 14 Fields:
Cel Cell Biology
Translation:Humans Cells
Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6413-8. Kim SJ, Syed GH, Khan M, Chiu WW, Sohail MA, Gish RG, Siddiqui A. PMID: 24733894; PMCID: PMC4035934.

View in: PubMed Mentions: 165 Fields:
Sci Science
Translation:Humans Cells
Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation. J Virol. 2014 Mar; 88(5):2519-29. Syed GH, Tang H, Khan M, Hassanein T, Liu J, Siddiqui A. PMID: 24352472; PMCID: PMC3958050.

View in: PubMed Mentions: 47 Fields:
Vir Virology
Translation:Humans Cells
Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis. PLoS Pathog. 2013; 9(12):e1003722. Kim SJ, Khan M, Quan J, Till A, Subramani S, Siddiqui A. PMID: 24339771; PMCID: PMC3855539.

View in: PubMed Mentions: 169 Fields:
Mic Microbiology
Translation:Humans Cells
Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog. 2013 Mar; 9(3):e1003285. Kim SJ, Syed GH, Siddiqui A. PMID: 23555273; PMCID: PMC3610669.

View in: PubMed Mentions: 108 Fields:
Mic Microbiology
Translation:Humans Cells
Phosphoinositides in the hepatitis C virus life cycle. Viruses. 2012 Oct 19; 4(10):2340-58. Bishé B, Syed G, Siddiqui A. PMID: 23202467; PMCID: PMC3497055.

View in: PubMed Mentions: 22 Fields:
Vir Virology
Translation:Humans Animals Cells
Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. J Biol Chem. 2012 Aug 10; 287(33):27637-47. Bishé B, Syed GH, Field SJ, Siddiqui A. PMID: 22745132; PMCID: PMC3431621.

View in: PubMed Mentions: 55 Fields:
Bio Biochemistry
Translation:Humans Cells
Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus. Hepatology. 2011 Dec; 54(6):1936-46. Syed GH, Siddiqui A. PMID: 21858850; PMCID: PMC3236615.

View in: PubMed Mentions: 31 Fields:
Gas Gastroenterology
Translation:Humans Cells
Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein. J Biol Chem. 2011 Apr 01; 286(13):11265-74. Amako Y, Syed GH, Siddiqui A. PMID: 21285358; PMCID: PMC3064182.

View in: PubMed Mentions: 51 Fields:
Bio Biochemistry
Translation:Cells
Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol Metab. 2010 Jan; 21(1):33-40. Syed GH, Amako Y, Siddiqui A. PMID: 19854061; PMCID: PMC2818172.

View in: PubMed Mentions: 170 Fields:
End Endocrinology Met Metabolism
Translation:Humans Animals Cells
Role of oxysterol binding protein in hepatitis C virus infection. J Virol. 2009 Sep; 83(18):9237-46. Amako Y, Sarkeshik A, Hotta H, Yates J, Siddiqui A. PMID: 19570870; PMCID: PMC2738263.

View in: PubMed Mentions: 74 Fields:
Vir Virology
Translation:Humans Cells
Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J Virol. 2007 Oct; 81(19):10249-57. Nasimuzzaman M, Waris G, Mikolon D, Stupack DG, Siddiqui A. PMID: 17626077; PMCID: PMC2045478.

View in: PubMed Mentions: 57 Fields:
Vir Virology
Translation:Humans Animals Cells
Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol. 2007 Aug; 81(15):8122-30. Waris G, Felmlee DJ, Negro F, Siddiqui A. PMID: 17507484; PMCID: PMC1951320.

View in: PubMed Mentions: 111 Fields:
Vir Virology
Translation:Humans Animals Cells
Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol. 2007 Jun; 81(12):6757-60. Chen J, Siddiqui A. PMID: 17428866; PMCID: PMC1900104.

View in: PubMed Mentions: 34 Fields:
Vir Virology
Translation:Humans Cells
Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion. J Biol Chem. 2005 Dec 02; 280(48):39802-8. Domitrovich AM, Felmlee DJ, Siddiqui A. PMID: 16203724.

View in: PubMed Mentions: 35 Fields:
Bio Biochemistry
Translation:Humans Cells