Aleem Siddiqui

Title(s)Recall Hcomp, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Epitranscriptomic regulation of HBV gene expression
    NIH R01AI139234Mar 1, 2019 - Feb 29, 2024
    Role: Principal Investigator
    Epitranscriptomic regulation of HBV gene expression
    NIH R56AI139234Jul 16, 2018 - Feb 28, 2019
    Role: Principal Investigator
    Mechanisms of HBV-Induced Innate Immunity
    NIH R01AI125350Jun 23, 2017 - May 31, 2022
    Role: Principal Investigator
    2016 Internatinal Meeting o the Molecular Biology of Hepatitis B Viruses
    NIH R13AI124562Jul 19, 2016 - Jun 30, 2017
    Role: Principal Investigator
    Intervention of HBV DNA synthesis and transcription
    NIH R21AI105939Sep 6, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Hepatitis C Virus-Induced Liver Pathogenesis
    NIH R01DK083479Sep 30, 2010 - Aug 31, 2014
    Role: Principal Investigator
    Role of Lipids in Hepatitis C Virus Maturation
    NIH R01AI085087Jul 1, 2010 - Mar 31, 2020
    Role: Principal Investigator
    Role of Lipids in Hepatitis C Virus Maturation
    NIH R56AI085087Dec 1, 2009 - Mar 31, 2015
    Role: Principal Investigator
    Viral Hepatitis C and Lipid Homeostasis
    NIH R01DK077704Apr 1, 2007 - Dec 31, 2017
    Role: Principal Investigator
    Determinants of Liver Injury in Chronic Hepatitis C Virus Infection
    NIH U19AI066313Sep 1, 2005 - Nov 28, 2010
    Role: Co-Investigator
    Hepatitis C Virus NS5a Protein and Oxidative Stress
    NIH R01DK061566Jan 8, 2003 - Dec 31, 2008
    Role: Principal Investigator
    NIH R01CA078769Jan 19, 2000 - Dec 31, 2004
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    HBV induced Liver Pathogenesis
    NIH R01CA064415Apr 1, 1996 - Sep 30, 2007
    Role: Principal Investigator
    NIH R03AI031994Sep 15, 1991 - Aug 31, 1994
    Role: Principal Investigator
    NIH U01AI021182Apr 1, 1984 - Mar 31, 1987
    Role: Principal Investigator
    NIH R01CA033135Jul 1, 1982 - Nov 30, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. N6-Methyladenine Modification of Hepatitis Delta Virus Regulates Its Virion Assembly by Recruiting YTHDF1. J Virol. 2022 10 12; 96(19):e0112422. Kim GW, Moon JS, Gudima SO, Siddiqui A. PMID: 36102650; PMCID: PMC9555152.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. N6-methyladenosine modification of the 5' epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein. Proc Natl Acad Sci U S A. 2022 02 15; 119(7). Kim GW, Moon JS, Siddiqui A. PMID: 35135882; PMCID: PMC8851549.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    3. Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA. J Virol. 2022 02 23; 96(4):e0165521. Kim GW, Siddiqui A. PMID: 34851655; PMCID: PMC8865537.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    4. The RNA Binding Proteins YTHDC1 and FMRP Regulate the Nuclear Export of N6-Methyladenosine-Modified Hepatitis B Virus Transcripts and Affect the Viral Life Cycle. J Virol. 2021 06 10; 95(13):e0009721. Kim GW, Imam H, Siddiqui A. PMID: 33883220; PMCID: PMC8316146.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    5. The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses. Exp Mol Med. 2021 03; 53(3):339-345. Kim GW, Siddiqui A. PMID: 33742132; PMCID: PMC8080661.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    6. N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). Kim GW, Siddiqui A. PMID: 33649237; PMCID: PMC7958429.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    7. Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). Kim GW, Siddiqui A. PMID: 33397803; PMCID: PMC7826408.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    8. Epitranscriptomic(N6-methyladenosine) Modification of Viral RNA and Virus-Host Interactions. Front Cell Infect Microbiol. 2020; 10:584283. Imam H, Kim GW, Siddiqui A. PMID: 33330128; PMCID: PMC7732492.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    9. HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC. Hepatology. 2021 02; 73(2):533-547. Kim GW, Imam H, Khan M, Mir SA, Kim SJ, Yoon SK, Hur W, Siddiqui A. PMID: 32394474; PMCID: PMC7655655.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    10. Retraction for Waris et al., "Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress". J Virol. 2020 09 15; 94(19). Waris G, Felmlee DJ, Negro F, Siddiqui A. PMID: 32934072; PMCID: PMC7495369.
      View in: PubMed   Mentions:    Fields:    
    11. Retraction for Nasimuzzaman et al., "Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor". J Virol. 2020 09 15; 94(19). Nasimuzzaman M, Waris G, Mikolon D, Stupack DG, Siddiqui A. PMID: 32934071; PMCID: PMC7495360.
      View in: PubMed   Mentions:    Fields:    
    12. N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling. J Biol Chem. 2020 09 11; 295(37):13123-13133. Kim GW, Imam H, Khan M, Siddiqui A. PMID: 32719095; PMCID: PMC7489896.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    13. Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts. PLoS Pathog. 2020 02; 16(2):e1008338. Imam H, Kim GW, Mir SA, Khan M, Siddiqui A. PMID: 32059034; PMCID: PMC7046284.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    14. Subversion of cellular autophagy during virus infection: Insights from hepatitis B and hepatitis C viruses. Liver Res. 2018 Sep; 2(3):146-156. Khan M, Imam H, Siddiqui A. PMID: 31803515; PMCID: PMC6892584.
      View in: PubMed   Mentions: 11  
    15. N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):8829-8834. Imam H, Khan M, Gokhale NS, McIntyre ABR, Kim GW, Jang JY, Kim SJ, Mason CE, Horner SM, Siddiqui A. PMID: 30104368; PMCID: PMC6126736.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    16. Hepatitis C Virus Lipoviroparticles Assemble in the Endoplasmic Reticulum (ER) and Bud off from the ER to the Golgi Compartment in COPII Vesicles. J Virol. 2017 08 01; 91(15). Syed GH, Khan M, Yang S, Siddiqui A. PMID: 28515296; PMCID: PMC5512234.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    17. Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity. PLoS Pathog. 2016 06; 12(6):e1005693. Khan M, Syed GH, Kim SJ, Siddiqui A. PMID: 27348524; PMCID: PMC4922663.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    18. Mitochondrial dynamics and viral infections: A close nexus. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt B):2822-33. Khan M, Syed GH, Kim SJ, Siddiqui A. PMID: 25595529; PMCID: PMC4500740.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    19. Evolutionary trends and functional anatomy of the human expanded autophagy network. Autophagy. 2015; 11(9):1652-67. Till A, Saito R, Merkurjev D, Liu JJ, Syed GH, Kolnik M, Siddiqui A, Glas M, Scheffler B, Ideker T, Subramani S. PMID: 26103419; PMCID: PMC4590607.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6413-8. Kim SJ, Syed GH, Khan M, Chiu WW, Sohail MA, Gish RG, Siddiqui A. PMID: 24733894; PMCID: PMC4035934.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCells
    21. Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation. J Virol. 2014 Mar; 88(5):2519-29. Syed GH, Tang H, Khan M, Hassanein T, Liu J, Siddiqui A. PMID: 24352472; PMCID: PMC3958050.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    22. Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis. PLoS Pathog. 2013; 9(12):e1003722. Kim SJ, Khan M, Quan J, Till A, Subramani S, Siddiqui A. PMID: 24339771; PMCID: PMC3855539.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    23. Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog. 2013 Mar; 9(3):e1003285. Kim SJ, Syed GH, Siddiqui A. PMID: 23555273; PMCID: PMC3610669.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    24. Phosphoinositides in the hepatitis C virus life cycle. Viruses. 2012 Oct 19; 4(10):2340-58. Bishé B, Syed G, Siddiqui A. PMID: 23202467; PMCID: PMC3497055.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    25. Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. J Biol Chem. 2012 Aug 10; 287(33):27637-47. Bishé B, Syed GH, Field SJ, Siddiqui A. PMID: 22745132; PMCID: PMC3431621.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    26. Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus. Hepatology. 2011 Dec; 54(6):1936-46. Syed GH, Siddiqui A. PMID: 21858850; PMCID: PMC3236615.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    27. Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein. J Biol Chem. 2011 Apr 01; 286(13):11265-74. Amako Y, Syed GH, Siddiqui A. PMID: 21285358; PMCID: PMC3064182.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    28. Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol Metab. 2010 Jan; 21(1):33-40. Syed GH, Amako Y, Siddiqui A. PMID: 19854061; PMCID: PMC2818172.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimalsCells
    29. Role of oxysterol binding protein in hepatitis C virus infection. J Virol. 2009 Sep; 83(18):9237-46. Amako Y, Sarkeshik A, Hotta H, Yates J, Siddiqui A. PMID: 19570870; PMCID: PMC2738263.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    30. Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J Virol. 2007 Oct; 81(19):10249-57. Nasimuzzaman M, Waris G, Mikolon D, Stupack DG, Siddiqui A. PMID: 17626077; PMCID: PMC2045478.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    31. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol. 2007 Aug; 81(15):8122-30. Waris G, Felmlee DJ, Negro F, Siddiqui A. PMID: 17507484; PMCID: PMC1951320.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    32. Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol. 2007 Jun; 81(12):6757-60. Chen J, Siddiqui A. PMID: 17428866; PMCID: PMC1900104.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    33. Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion. J Biol Chem. 2005 Dec 02; 280(48):39802-8. Domitrovich AM, Felmlee DJ, Siddiqui A. PMID: 16203724.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
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