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Aleem Siddiqui

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0711
La Jolla CA 92093
Phone858-822-1750
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of HBV-Induced Innate Immunity
    NIH/NIAID R01AI125350Jun 23, 2017 - May 31, 2022
    Role: Principal Investigator
    2016 Internatinal Meeting o the Molecular Biology of Hepatitis B Viruses
    NIH/NIAID R13AI124562Jul 19, 2016 - Jun 30, 2017
    Role: Principal Investigator
    Intervention of HBV DNA synthesis and transcription
    NIH/NIAID R21AI105939Sep 6, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Hepatitis C Virus-Induced Liver Pathogenesis
    NIH/NIDDK R01DK083479Sep 30, 2010 - Aug 31, 2014
    Role: Principal Investigator
    Role of Lipids in Hepatitis C Virus Maturation
    NIH/NIAID R01AI085087Dec 1, 2009 - Mar 31, 2019
    Role: Principal Investigator
    Role of Lipids in Hepatitis C Virus Maturation
    NIH/NIAID R56AI085087Dec 1, 2009 - Jul 31, 2015
    Role: Principal Investigator
    Viral Hepatitis C and Lipid Homeostasis
    NIH/NIDDK R01DK077704Apr 1, 2007 - Dec 31, 2017
    Role: Principal Investigator
    Determinants of Liver Injury in Chronic Hepatitis C Virus Infection
    NIH U19AI066313Sep 1, 2005 - Nov 28, 2010
    Role: Co-Investigator
    Hepatitis C Virus NS5a Protein and Oxidative Stress
    NIH/NIDDK R01DK061566Jan 8, 2003 - Dec 31, 2008
    Role: Principal Investigator
    LIVER-SPECIFIC EXPRESSION OF HBV GENES
    NIH/NCI R01CA078769Jan 19, 2000 - Dec 31, 2004
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    HBV induced Liver Pathogenesis
    NIH/NCI R01CA064415Apr 1, 1996 - Sep 30, 2007
    Role: Principal Investigator
    INDO-US VACCINE ACTION PROGRAM
    NIH/NIAID R03AI031994Sep 15, 1991 - Aug 31, 1994
    Role: Principal Investigator
    HEPATITIS B VIRUS DNA AS COCARCINOGEN IN KAPOSI SARCOMA
    NIH/NIAID U01AI021182Apr 1, 1984 - Mar 31, 1987
    Role: Principal Investigator
    EXPRESSION OF HBV GENES AND HEPATOMA
    NIH/NCI R01CA033135Jul 1, 1982 - Nov 30, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim SJ, Ahn DG, Syed GH, Siddiqui A. The essential role of mitochondrial dynamics in antiviral immunity. Mitochondrion. 2017 Dec 05. PMID: 29246869.
      View in: PubMed
    2. Kim SJ, Jang JY, Kim EJ, Cho EK, Ahn DG, Kim C, Park HS, Jeong SW, Lee SH, Kim SG, Kim YS, Kim HS, Kim BS, Lee J, Siddiqui A. Ginsenoside Rg3 restores hepatitis C virus-induced aberrant mitochondrial dynamics and inhibits virus propagation. Hepatology. 2017 09; 66(3):758-771. PMID: 28329914.
      View in: PubMed
    3. Syed GH, Khan M, Yang S, Siddiqui A. Hepatitis C Virus Lipoviroparticles Assemble in the Endoplasmic Reticulum (ER) and Bud off from the ER to the Golgi Compartment in COPII Vesicles. J Virol. 2017 08 01; 91(15). PMID: 28515296.
      View in: PubMed
    4. Khan M, Syed GH, Kim SJ, Siddiqui A. Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity. PLoS Pathog. 2016 Jun; 12(6):e1005693. PMID: 27348524; PMCID: PMC4922663.
    5. Slagle BL, Andrisani OM, Bouchard MJ, Lee CG, Ou JH, Siddiqui A. Technical standards for hepatitis B virus X protein (HBx) research. Hepatology. 2015 Apr; 61(4):1416-24. PMID: 25099228; PMCID: PMC4320676.
    6. Amako Y, Munakata T, Kohara M, Siddiqui A, Peers C, Harris M. Hepatitis C virus attenuates mitochondrial lipid ß-oxidation by downregulating mitochondrial trifunctional-protein expression. J Virol. 2015 Apr; 89(8):4092-101. PMID: 25673715; PMCID: PMC4442397.
    7. Khan M, Syed GH, Kim SJ, Siddiqui A. Mitochondrial dynamics and viral infections: A close nexus. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt B):2822-33. PMID: 25595529; PMCID: PMC4500740 [Available on 10/01/16].
    8. Till A, Saito R, Merkurjev D, Liu JJ, Syed GH, Kolnik M, Siddiqui A, Glas M, Scheffler B, Ideker T, Subramani S. Evolutionary trends and functional anatomy of the human expanded autophagy network. Autophagy. 2015; 11(9):1652-67. PMID: 26103419; PMCID: PMC4590607.
    9. Soto-Acosta R, Bautista-Carbajal P, Syed GH, Siddiqui A, Del Angel RM. Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus. Antiviral Res. 2014 Sep; 109:132-40. PMID: 25017471.
      View in: PubMed
    10. Kim SJ, Syed GH, Khan M, Chiu WW, Sohail MA, Gish RG, Siddiqui A. Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6413-8. PMID: 24733894; PMCID: PMC4035934.
    11. Syed GH, Tang H, Khan M, Hassanein T, Liu J, Siddiqui A. Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation. J Virol. 2014 Mar; 88(5):2519-29. PMID: 24352472; PMCID: PMC3958050.
    12. Kim SJ, Khan M, Quan J, Till A, Subramani S, Siddiqui A. Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis. PLoS Pathog. 2013; 9(12):e1003722. PMID: 24339771; PMCID: PMC3855539.
    13. Kim SJ, Syed GH, Siddiqui A. Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog. 2013 Mar; 9(3):e1003285. PMID: 23555273; PMCID: PMC3610669.
    14. Bishé B, Syed G, Siddiqui A. Phosphoinositides in the hepatitis C virus life cycle. Viruses. 2012 Oct 19; 4(10):2340-58. PMID: 23202467; PMCID: PMC3497055.
    15. Bishé B, Syed GH, Field SJ, Siddiqui A. Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. J Biol Chem. 2012 Aug 10; 287(33):27637-47. PMID: 22745132; PMCID: PMC3431621.
    16. Syed GH, Siddiqui A. Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus. Hepatology. 2011 Dec; 54(6):1936-46. PMID: 21858850; PMCID: PMC3236615.
    17. Amako Y, Syed GH, Siddiqui A. Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein. J Biol Chem. 2011 Apr 01; 286(13):11265-74. PMID: 21285358; PMCID: PMC3064182.
    18. Syed GH, Amako Y, Siddiqui A. Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol Metab. 2010 Jan; 21(1):33-40. PMID: 19854061; PMCID: PMC2818172.
    19. Amako Y, Sarkeshik A, Hotta H, Yates J, Siddiqui A. Role of oxysterol binding protein in hepatitis C virus infection. J Virol. 2009 Sep; 83(18):9237-46. PMID: 19570870; PMCID: PMC2738263.
    20. Nasimuzzaman M, Waris G, Mikolon D, Stupack DG, Siddiqui A. Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J Virol. 2007 Oct; 81(19):10249-57. PMID: 17626077; PMCID: PMC2045478.
    21. Waris G, Felmlee DJ, Negro F, Siddiqui A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol. 2007 Aug; 81(15):8122-30. PMID: 17507484; PMCID: PMC1951320.
    22. Chen J, Siddiqui A. Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol. 2007 Jun; 81(12):6757-60. PMID: 17428866; PMCID: PMC1900104.
    23. Domitrovich AM, Felmlee DJ, Siddiqui A. Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion. J Biol Chem. 2005 Dec 02; 280(48):39802-8. PMID: 16203724.
      View in: PubMed
    24. Waris G, Siddiqui A. Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication. J Virol. 2005 Aug; 79(15):9725-34. PMID: 16014934; PMCID: PMC1181604.
    25. Domitrovich AM, Diebel KW, Ali N, Sarker S, Siddiqui A. Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication. Virology. 2005 Apr 25; 335(1):72-86. PMID: 15823607.
      View in: PubMed
    26. Tardif KD, Waris G, Siddiqui A. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol. 2005 Apr; 13(4):159-63. PMID: 15817385.
      View in: PubMed
    27. Waris G, Turkson J, Hassanein T, Siddiqui A. Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication. J Virol. 2005 Feb; 79(3):1569-80. PMID: 15650183; PMCID: PMC544105.
    28. Tardif KD, Mori K, Kaufman RJ, Siddiqui A. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem. 2004 Apr 23; 279(17):17158-64. PMID: 14960590.
      View in: PubMed
    29. Waris G, Sarker S, Siddiqui A. Two-step affinity purification of the hepatitis C virus ribonucleoprotein complex. RNA. 2004 Feb; 10(2):321-9. PMID: 14730030; PMCID: PMC1370543.
    30. Gong GZ, Siddiqui A, Su XS. [The effect of Hepatitis C virus nonstructural protein 5A on cell cycling]. Zhonghua Gan Zang Bing Za Zhi. 2004 Jan; 12(1):47-8. PMID: 14761287.
      View in: PubMed
    31. Tardif KD, Siddiqui A. Cell surface expression of major histocompatibility complex class I molecules is reduced in hepatitis C virus subgenomic replicon-expressing cells. J Virol. 2003 Nov; 77(21):11644-50. PMID: 14557650; PMCID: PMC229359.
    32. Waris G, Livolsi A, Imbert V, Peyron JF, Siddiqui A. Hepatitis C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease. J Biol Chem. 2003 Oct 17; 278(42):40778-87. PMID: 12909638.
      View in: PubMed
    33. Ali N, Tardif KD, Siddiqui A. Cell-free replication of the hepatitis C virus subgenomic replicon. J Virol. 2002 Dec; 76(23):12001-7. PMID: 12414942; PMCID: PMC136887.
    34. Waris G, Tardif KD, Siddiqui A. Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3. Biochem Pharmacol. 2002 Nov 15; 64(10):1425-30. PMID: 12417255.
      View in: PubMed
    35. Tardif KD, Mori K, Siddiqui A. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J Virol. 2002 Aug; 76(15):7453-9. PMID: 12097557; PMCID: PMC136367.
    36. Waris G, Siddiqui A. Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function. J Virol. 2002 Mar; 76(6):2721-9. PMID: 11861839; PMCID: PMC135980.
    37. Huh KW, Siddiqui A. Characterization of the mitochondrial association of hepatitis B virus X protein, HBx. Mitochondrion. 2002 Feb; 1(4):349-59. PMID: 16120289.
      View in: PubMed
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